Systemic sclerosis and its cerebral, neurological, and psychiatric impacts: a narrative review

IF 2.6 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2025-06-12 DOI:10.1016/j.brainres.2025.149779

Ryan C. Silva , Josenilda de M. Arruda , Michelly C. Pereira , Moacyr J.B.M. Rêgo , Maira G.R. Pitta , Michelle M. da Rosa

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Abstract

Neurological manifestations of Systemic Sclerosis (SSc) encompass psychiatric disorders, peripheral neuropathy (PN), and cerebrovascular complications, significantly impacting patient quality of life. Psychological assessments reveal high levels of distress linked to depression, anxiety, fatigue, and cognitive impairment. Although PN is less frequent, its distinct profile in SSc suggests intrinsic disease mechanisms, sometimes presenting as an early symptom. Key features of SSc, including microvascular dysfunction, fibroproliferative processes, and vasculitis, elevate stroke risk through atherosclerosis and vascular calcification. Additionally, oxidative stress plays a central role in neural damage, with Reactive Oxygen Species (ROS) contributing to neurological symptoms. This review highlights the diverse neurological outcomes of SSc, underscoring the need for integrative management strategies that address overlooked comorbidities and optimize patient care.

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系统性硬化症及其对大脑、神经和精神的影响：叙述性综述。

系统性硬化症（SSc）的神经学表现包括精神障碍、周围神经病变（PN）和脑血管并发症，严重影响患者的生活质量。心理评估显示，高水平的痛苦与抑郁、焦虑、疲劳和认知障碍有关。虽然PN不太常见，但其在SSc中的独特特征提示了内在的疾病机制，有时表现为早期症状。SSc的主要特征，包括微血管功能障碍、纤维增生过程和血管炎，通过动脉粥样硬化和血管钙化提高卒中风险。此外，氧化应激在神经损伤中起核心作用，活性氧（ROS）导致神经系统症状。这篇综述强调了SSc的神经学预后的多样性，强调了解决被忽视的合并症和优化患者护理的综合管理策略的必要性。

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.