Trophic factors and essential oils as potential neuromodulators of Renin-Angiotensin system

IF 2.7 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2025-06-10 DOI:10.1016/j.brainres.2025.149777

Rosana Crespo , Sol Angulo , Lucía Nigro , Rocío Bartolozzi , Claudia Hereñú

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引用次数: 0

Abstract

The renin-angiotensin system (RAS) is a well-established endocrine system primarily recognized for its role in electrolyte homeostasis, fluid balance, and cardiovascular regulation in peripheral circulation. In addition to the systemic RAS, the brain harbors a local and independent RAS.

Accumulating evidence indicates a close association between the renin-angiotensin system (RAS) and neuroinflammation. This report underscores the pathophysiology role of RAS in neurodegeneration and evaluates its potential as a therapeutic target.

Growth factors and essential oil have been widely studied for their antioxidant therapeutic potential in inflammatory disorders and other pathologies. Studies on the administration of these molecules have been tested for their potential to provide neuroprotection and stop or slow the progression of neurodegenerative diseases. As a result of these searches, we suggest that growth factors and essential oils neuroprotective effects may be mediated, at least in part, by their interactions with the RAS system influencing neurovascular and neuroinflammatory processes.

This review intends to summarize and provide evidence to guide future research on the effects of growth factors and essential oils on brain RAS components and their potential therapeutic applications in neuroprotection.

Abstract Image

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肾素-血管紧张素系统中营养因子和精油的潜在神经调节剂作用。

肾素-血管紧张素系统（RAS）是一个完善的内分泌系统，主要被认为在电解质稳态、液体平衡和外周循环心血管调节中起作用。除了系统的RAS外，大脑还有一个局部和独立的RAS。越来越多的证据表明肾素-血管紧张素系统（RAS）与神经炎症密切相关。本报告强调RAS在神经退行性变中的病理生理作用，并评估其作为治疗靶点的潜力。生长因子和精油因其抗氧化治疗炎症性疾病和其他疾病的潜力而被广泛研究。对这些分子的施用进行了研究，以证明它们具有提供神经保护和阻止或减缓神经退行性疾病进展的潜力。根据这些研究结果，我们认为生长因子和精油的神经保护作用可能是通过它们与影响神经血管和神经炎症过程的RAS系统的相互作用介导的，至少部分是这样。本文就生长因子和精油对脑RAS成分的影响及其在神经保护中的潜在治疗应用进行综述，为今后的研究提供依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.