Maternal exercise and neonatal overfeeding induces sex-specific peripheral and brain alterations in the offspring

IF 2.6 4区 医学 Q3 NEUROSCIENCES
Pauline Maciel August , Bernardo Gindri dos Santos , Ismael Mesquita , Alessandra Gonçalves Machado , Débora Santos Rocha , Eduardo Z.B. de Assis , Luisa Soares Pedroso , Vinicius Stone , Manuela Menegotto Zeferino , Carla Dalmaz , Cristiane Matté
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Abstract

Childhood obesity is rapidly increasing, resulting in long-term negative health consequences. The impact of early-life factors on adulthood health is described through the Developmental Origin of Health and Disease (DOHaD) concept, which links the metabolic effects of prenatal interventions to an increased risk of chronic non-communicable diseases later in life. Our study aimed to evaluate the influence of prenatal exercise and neonatal overfeeding on pup development, and peripheral metabolic parameters, as well as mitochondrial function and oxidative stress in the hypothalamus and hippocampus. Female Wistar rats were divided into two groups before and during pregnancy: (1) sedentary, and (2) swimming exercise. One day after birth, the litter size was adjusted to 8 pups or 3 pups per dam, leading to control and overfed subgroups within each maternal group. Maternal exercise and neonatal overfeeding resulted in an accelerated eye opening in the pups. Overfeeding-induced increased mesenteric fat in females was decreased by maternal exercise. In male pups, maternal exercise was able to prevent overfeeding-induced increased blood glucose. In the hippocampus we also found a sex-specific effect, with male pups born from exercised dams and raised in an overfeed environment showing impaired mitochondrial function. Overall, our data demonstrates a positive effect of maternal exercise in well-known overweight effects, such as body fat and blood glucose levels. In the male pup hippocampus, maternal exercise could not prevent the sex-specific effects caused by neonatal overfeeding.

Abstract Image

母亲的运动和新生儿的过度喂养会导致后代的外周和大脑发生性别特异性的改变。
儿童肥胖正在迅速增加,造成长期的负面健康后果。早期生活因素对成年健康的影响是通过健康和疾病的发育起源概念来描述的,该概念将产前干预的代谢影响与生命后期慢性非传染性疾病风险增加联系起来。我们的研究旨在评估产前运动和新生儿过度喂养对幼鼠发育、外周代谢参数、下丘脑和海马线粒体功能和氧化应激的影响。雌性Wistar大鼠在怀孕前和怀孕期间分为两组:(1)久坐,(2)游泳运动。出生后第1天,将产仔数调整为每坝8只或3只,在每个母鼠组中形成控制和过量喂养亚组。母亲的运动和新生儿的过度喂养导致幼崽的眼睛加速睁开。过度喂养引起的雌性肠系膜脂肪增加可以通过母体运动来减少。在雄性幼崽中,母亲运动能够防止过量喂养引起的血糖升高。在海马体中,我们也发现了一种性别特异性的影响,在过度喂养的环境中出生的雄性幼崽表现出线粒体功能受损。总的来说,我们的数据表明,孕妇运动对众所周知的超重效应(如体脂和血糖水平)有积极影响。在雄仔海马中,母鼠运动不能阻止新生儿过度喂养引起的性别特异性效应。
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来源期刊
Brain Research
Brain Research 医学-神经科学
CiteScore
5.90
自引率
3.40%
发文量
268
审稿时长
47 days
期刊介绍: An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.
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