Pauline Maciel August , Bernardo Gindri dos Santos , Ismael Mesquita , Alessandra Gonçalves Machado , Débora Santos Rocha , Eduardo Z.B. de Assis , Luisa Soares Pedroso , Vinicius Stone , Manuela Menegotto Zeferino , Carla Dalmaz , Cristiane Matté
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引用次数: 0
Abstract
Childhood obesity is rapidly increasing, resulting in long-term negative health consequences. The impact of early-life factors on adulthood health is described through the Developmental Origin of Health and Disease (DOHaD) concept, which links the metabolic effects of prenatal interventions to an increased risk of chronic non-communicable diseases later in life. Our study aimed to evaluate the influence of prenatal exercise and neonatal overfeeding on pup development, and peripheral metabolic parameters, as well as mitochondrial function and oxidative stress in the hypothalamus and hippocampus. Female Wistar rats were divided into two groups before and during pregnancy: (1) sedentary, and (2) swimming exercise. One day after birth, the litter size was adjusted to 8 pups or 3 pups per dam, leading to control and overfed subgroups within each maternal group. Maternal exercise and neonatal overfeeding resulted in an accelerated eye opening in the pups. Overfeeding-induced increased mesenteric fat in females was decreased by maternal exercise. In male pups, maternal exercise was able to prevent overfeeding-induced increased blood glucose. In the hippocampus we also found a sex-specific effect, with male pups born from exercised dams and raised in an overfeed environment showing impaired mitochondrial function. Overall, our data demonstrates a positive effect of maternal exercise in well-known overweight effects, such as body fat and blood glucose levels. In the male pup hippocampus, maternal exercise could not prevent the sex-specific effects caused by neonatal overfeeding.
期刊介绍:
An international multidisciplinary journal devoted to fundamental research in the brain sciences.
Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed.
With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.