Biointerphases最新文献_第3页

Performance of biological food processing interfaces: Perspectives on the science of mollusc radula. 生物食品加工界面的性能：软体动物桡足类科学的前景。

IF 1.6 4区医学

Biointerphases Pub Date : 2024-05-01 DOI: 10.1116/6.0003672

Wencke Krings, Stanislav N Gorb

{"title":"Performance of biological food processing interfaces: Perspectives on the science of mollusc radula.","authors":"Wencke Krings, Stanislav N Gorb","doi":"10.1116/6.0003672","DOIUrl":"https://doi.org/10.1116/6.0003672","url":null,"abstract":"The Mollusca comprises a diverse range of organisms, with the class Gastropoda alone boasting approximately 80 000 extant species. Their adaptability across various habitats is facilitated by the evolution of the radula, a key structure for food acquisition. The radula's composition and mechanical properties, including its chitinous membrane, teeth, and supporting structures, enable efficient food gathering and processing. Through adaptive tooth morphology and composition, an interplay between radular components is facilitated, which results in collective effects to withstand forces encountered during feeding and reduce structural failure, with the broad range of variations reflecting ecological niches. Furthermore, teeth consist of composite materials with sometimes high contents of iron, calcium, or silicon to reduce wear. During interaction with the food, the radula performs complex three-dimensional motions, challenging to document. Here, we provide a review on the morphology, the mechanical properties, the composition, and various other parameters that contribute to radular performance. Due to, e.g., the smallness of these structures, there are, however, limitations to radular research. However, numerical simulations and physical models tested on substrates offer avenues for further understanding radular function and performance during feeding. These studies not only advance our knowledge of molluscan biology and ecology but also provide inspirations for biomimetic design and further advances in materials engineering.","PeriodicalId":9053,"journal":{"name":"Biointerphases","volume":"19 3","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling the effect of magnetoelectric nanoparticles on neuronal electrical activity: An analog circuit approach. 磁电纳米粒子对神经元电活动影响的建模：模拟电路方法

IF 2.1 4区医学

Biointerphases Pub Date : 2024-05-01 DOI: 10.1116/5.0199163

Zeinab Ramezani, Victoria André, Sakhrat Khizroev

{"title":"Modeling the effect of magnetoelectric nanoparticles on neuronal electrical activity: An analog circuit approach.","authors":"Zeinab Ramezani, Victoria André, Sakhrat Khizroev","doi":"10.1116/5.0199163","DOIUrl":"https://doi.org/10.1116/5.0199163","url":null,"abstract":"This paper introduces a physical neuron model that incorporates magnetoelectric nanoparticles (MENPs) as an essential electrical circuit component to wirelessly control local neural activity. Availability of such a model is important as MENPs, due to their magnetoelectric effect, can wirelessly and noninvasively modulate neural activity, which, in turn, has implications for both finding cures for neurological diseases and creating a wireless noninvasive high-resolution brain-machine interface. When placed on a neuronal membrane, MENPs act as magnetic-field-controlled finite-size electric dipoles that generate local electric fields across the membrane in response to magnetic fields, thus allowing to controllably activate local ion channels and locally initiate an action potential. Herein, the neuronal electrical characteristic description is based on ion channel activation and inhibition mechanisms. A MENP-based memristive Hodgkin-Huxley circuit model is extracted by combining the Hodgkin-Huxley model and an equivalent circuit model for a single MENP. In this model, each MENP becomes an integral part of the neuron, thus enabling wireless local control of the neuron's electric circuit itself. Furthermore, the model is expanded to include multiple MENPs to describe collective effects in neural systems.","PeriodicalId":9053,"journal":{"name":"Biointerphases","volume":"19 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140911054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipids and proteins: Insights into the dynamics of assembly, recognition, condensate formation. What is still missing? 脂质和蛋白质：对组装、识别和凝结物形成动力学的见解。还缺少什么？

IF 1.6 4区医学

Biointerphases Pub Date : 2024-05-01 DOI: 10.1116/6.0003662

Pablo G Argudo

引用次数: 0

Process optimization and character evaluation of Bletilla striata polysaccharide (BSP) and chitosan (CS) composite hemostatic sponge (BSP-CS). Bletilla striata 多糖（BSP）和壳聚糖（CS）复合止血海绵（BSP-CS）的工艺优化和特性评估。

IF 2.1 4区医学

Biointerphases Pub Date : 2024-03-01 DOI: 10.1116/6.0003369

Yeshan Zhang, Xue Han, Jun Zhao, Menglan Gan, Yaya Chen, Jinxia Zhang, Yu He, Mingkai Wu, Hai Liu

{"title":"Process optimization and character evaluation of Bletilla striata polysaccharide (BSP) and chitosan (CS) composite hemostatic sponge (BSP-CS).","authors":"Yeshan Zhang, Xue Han, Jun Zhao, Menglan Gan, Yaya Chen, Jinxia Zhang, Yu He, Mingkai Wu, Hai Liu","doi":"10.1116/6.0003369","DOIUrl":"10.1116/6.0003369","url":null,"abstract":"Bletilla striata polysaccharide (BSP) and chitosan (CS) were chemically cross-linked using oxalyl chloride to prepare a composite hemostatic sponge (BSP-CS), and the process parameters were optimized using the Box-Behnken design (BBD) with response surface methodology. To optimize the performance of the hemostatic sponge, we adjusted the ratio of independent variables, the amount of oxalyl chloride added, and the freeze-dried volume. A series of evaluations were conducted on the hemostatic applicability of BSP-CS. The characterization results revealed that BSP-CS had a stable bacteriostatic effect on Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa within 72 h, and the bacteriostatic rate was above 30%. The CCK-8 cytotoxicity test demonstrated that BSP-CS had a certain effect on promoting cell proliferation of L929 cells. In the mouse tail-cutting experiment, the hemostasis time of BSP-CS was 463.0±38.16 s, shortened by 91.3 s on average compared with 554.3±34.67 s of the gauze group. The blood loss of the BSP-CS group was 28.47±3.74 mg, which was 34.7% lower than that of the control gauze group (43.6±3.83 mg). In the in vitro coagulation experiment, the in vitro coagulation index of the BSP-CS group was 97.29%±1.8%, which was reduced to 8.6% of the control group. The CT value of the BSP-CS group was 240±15 s, which was 155 s lower than that of the gauze group (355±31.22 s). All characterization results indicate that BSP-CS is an excellent hemostatic material.","PeriodicalId":9053,"journal":{"name":"Biointerphases","volume":"19 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aerosol inhalation of inflammatory cells-targeted dendrimer-dexamethasone conjugate for efficient allergic asthma therapy. 气溶胶吸入靶向炎症细胞的树枝状聚合物-地塞米松共轭物，用于过敏性哮喘的高效治疗。

IF 2.1 4区医学

Biointerphases Pub Date : 2024-03-01 DOI: 10.1116/6.0003480

Danfei Chen, Xiaobo Xuan, Yuyan Chen, Xia Fang, Liwei Liu, Guowei Wang, Jian Chen

{"title":"Aerosol inhalation of inflammatory cells-targeted dendrimer-dexamethasone conjugate for efficient allergic asthma therapy.","authors":"Danfei Chen, Xiaobo Xuan, Yuyan Chen, Xia Fang, Liwei Liu, Guowei Wang, Jian Chen","doi":"10.1116/6.0003480","DOIUrl":"10.1116/6.0003480","url":null,"abstract":"Allergic asthma (AA) is a common breathing disorder clinically characterized by the high occurrence of acute and continuous inflammation. However, the current treatment options for AA are lacking in effectiveness and diversity. In this study, we determined that the cell membrane receptor of gamma-glutamyl transferase (GGT) was highly overexpressed on the inflammatory cells that infiltrate the pulmonary tissues in AA cases. Therefore, we developed a GGT-specific dendrimer-dexamethasone conjugate (GSHDDC) that could be administered via aerosol inhalation to treat AA in a rapid and sustained manner. The GSHDDC was fabricated by the covalent attachment of 6-hydroxyhexyl acrylate-modified dexamethasone to polyamidoamine dendrimers via a carbonic ester linkage and the amino Michael addition, followed by the surface modification of the dendrimers with the GGT substrate of glutathione. After aerosol inhalation by the AA mice, the small particle-sized GSHDDC could easily diffuse into pulmonary alveoli and touch with the inflammatory cells via the glutathione ligand/GGT receptor-mediated recognition. The overexpressed GGT on the surface of inflammatory cells then triggers the gamma-glutamyl transfer reactions of glutathione to generate positively charged primary amines, thereby inducing rapid cationization-mediated cellular endocytosis into the inflammatory cells. The dexamethasone was gradually released by the intracellular enzyme hydrolysis, enabling sustained anti-inflammatory effects (e.g., reducing eosinophil infiltration, decreasing the levels of inflammatory factors) in the ovalbumin-induced AA mice. This study demonstrates the effectiveness of an inhalational and active inflammatory cells-targeted dendrimer-dexamethasone conjugate for efficient AA therapy.","PeriodicalId":9053,"journal":{"name":"Biointerphases","volume":"19 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered cell membrane-coated nanoparticles based cancer therapy: A robust weapon against the lethal and challenging hepatocellular carcinoma. 基于细胞膜涂层的工程纳米粒子癌症疗法：对抗致命且具有挑战性的肝细胞癌的有力武器。

IF 2.1 4区医学

Biointerphases Pub Date : 2024-03-01 DOI: 10.1116/6.0003204

Jiachen Zhang, Hongjuan Yu, Gang Li

引用次数: 0

IF 2.1 4区医学

Biointerphases Pub Date : 2024-03-01 DOI: 10.1116/6.0003437

Timo Weintraut, Sven Heiles, Dennis Gerbig, Anja Henss, Johannes Junck, Rolf-Alexander Düring, Marcus Rohnke

{"title":"Lipid-related ion suppression on the herbicide atrazine in earthworm samples in ToF-SIMS and matrix-assisted laser desorption ionization mass spectrometry imaging and the role of gas-phase basicity.","authors":"Timo Weintraut, Sven Heiles, Dennis Gerbig, Anja Henss, Johannes Junck, Rolf-Alexander Düring, Marcus Rohnke","doi":"10.1116/6.0003437","DOIUrl":"https://doi.org/10.1116/6.0003437","url":null,"abstract":"In mass spectrometry imaging (MSI), ion suppression can lead to a misinterpretation of results. Particularly phospholipids, most of which exhibit high gas-phase basicity (GB), are known to suppress the detection of metabolites and drugs. This study was initiated by the observation that the signal of an herbicide, i.e., atrazine, was suppressed in MSI investigations of earthworm tissue sections. Herbicide accumulation in earthworms was investigated by time-of-flight secondary ion mass spectrometry and matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI). Additionally, earthworm tissue sections without accumulation of atrazine but with a homogeneous spray deposition of the herbicide were analyzed to highlight region-specific ion suppression. Furthermore, the relationship of signal intensity and GB in binary mixtures of lipids, amino acids, and atrazine was investigated in both MSI techniques. The GB of atrazine was determined experimentally through a linear plot of the obtained intensity ratios of the binary amino acid mixtures, as well as theoretically. The GBs values for atrazine of 896 and 906 kJ/mol in ToF-SIMS and 933 and 987 kJ/mol in MALDI-MSI were determined experimentally and that of 913 kJ/mol by quantum mechanical calculations. Compared with the GB of a major lipid component, phosphatidylcholine (GBPC = 1044.7 kJ/mol), atrazine's experimentally and computationally determined GBs in this work are significantly lower, making it prone to ion suppression in biological samples containing polar lipids.","PeriodicalId":9053,"journal":{"name":"Biointerphases","volume":"19 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140853449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preface for the Biointerphases special topic collection on polymeric biointerfaces - a collection in celebration of Nicholas D. Spencer's career. 为纪念尼古拉斯-D-斯宾塞的职业生涯而出版的《生物界面》专题集《聚合物生物界面》作序。

IF 2.1 4区医学

Biointerphases Pub Date : 2024-01-01 DOI: 10.1116/6.0003375

Tobias Weidner

引用次数: 0

In situ Fourier transform infrared-attenuated total reflection spectroscopy and modeling investigation of protein adsorption: Case of expanded bovine serum albumin on titanium dioxide anatase. 蛋白质吸附的原位傅立叶变换红外全反射光谱和模型研究：二氧化钛锐钛矿上的膨胀牛血清白蛋白案例。

IF 2.1 4区医学

Biointerphases Pub Date : 2024-01-01 DOI: 10.1116/6.0003020

Moustafa Tadjine, Fatima Bouzidi, Abderrezak Berbri, Hamid Nehmar, Ahmed Bouhekka

{"title":"In situ Fourier transform infrared-attenuated total reflection spectroscopy and modeling investigation of protein adsorption: Case of expanded bovine serum albumin on titanium dioxide anatase.","authors":"Moustafa Tadjine, Fatima Bouzidi, Abderrezak Berbri, Hamid Nehmar, Ahmed Bouhekka","doi":"10.1116/6.0003020","DOIUrl":"10.1116/6.0003020","url":null,"abstract":"The purpose of this experimental and modeling research is to study the pH effect and to determine the surface coverage plus the adsorption constant (Ka) of bovine serum albumin (BSA) protein adsorbed on TiO2 anatase surface, respectively. In situ Fourier transform infrared-attenuated total reflection spectroscopy in a flow-through cell was used to study the BSA adsorption on porous TiO2 anatase films. The experiments were performed in water solution, under different pH values, at a concentration of 10-6 mol/l. Theoretically, we extended the two-state model, based on a system of coupled differential equations, by adding a desorption parameter Kd2, for unfolded state. The model was solved taking into account the adsorption (Ka), desorption (Kd1,2), transformation (Kf) coefficients, and the initial solution protein concentration (C0). The findings clearly illustrated that the solution pH drastically changed the behavior of BSA adsorption, whereas the mathematical analytical solutions allowed us to determine the native state (θ1), the unfolded state (θ2), and the full one (θ) surface coverages. Finally, a good application of the approximated model on the experimental work, expanded BSA adsorbed on TiO2 anatase at pH = 1.7, indicated a value of Ka = (408.36 ± 0.996) × 102 mol-1 l min-1.","PeriodicalId":9053,"journal":{"name":"Biointerphases","volume":"19 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139428280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfabricated free standing, tuneable, porous microfilters from an epoxy based photoresist for effective bioseparation. 利用环氧树脂光刻胶微加工出独立的、可调节的多孔微过滤器，实现有效的生物分离。

IF 2.1 4区医学

Biointerphases Pub Date : 2024-01-01 DOI: 10.1116/6.0003165

Sudeshna Sengupta, D Shyamala, Sivasundari Kannan, V T Fidal Kumar, Enakshi Bhattacharya

引用次数: 0