Biointerphases最新文献

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Fighting against biofilm: The antifouling and antimicrobial material. 对抗生物膜:防污抗菌材料。
IF 1.6 4区 医学
Biointerphases Pub Date : 2024-07-01 DOI: 10.1116/6.0003695
Chao Li, Dongdong Gao, Chunmei Li, Gang Cheng, Lijun Zhang
{"title":"Fighting against biofilm: The antifouling and antimicrobial material.","authors":"Chao Li, Dongdong Gao, Chunmei Li, Gang Cheng, Lijun Zhang","doi":"10.1116/6.0003695","DOIUrl":"https://doi.org/10.1116/6.0003695","url":null,"abstract":"<p><p>Biofilms are groups of microorganisms protected by self-secreted extracellular substances. Biofilm formation on the surface of biomaterial or engineering materials becomes a severe challenge. It has caused significant health, environmental, and societal concerns. It is believed that biofilms lead to life-threatening infection, medical implant failure, foodborne disease, and marine biofouling. To address these issues, tremendous effort has been made to inhibit biofilm formation on materials. Biofilms are extremely difficult to treat once formed, so designing material and coating bearing functional groups that are capable of resisting biofilm formation has attracted increasing attention for the last two decades. Many types of antibiofilm strategies have been designed to target different stages of biofilm formation. Development of the antibiofilm material can be classified into antifouling material, antimicrobial material, fouling release material, and integrated antifouling/antimicrobial material. This review summarizes relevant research utilizing these four approaches and comments on their antibiofilm properties. The feature of each method was compared to reveal the research trend. Antibiofilm strategies in fundamental research and industrial applications were summarized.</p>","PeriodicalId":9053,"journal":{"name":"Biointerphases","volume":"19 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141632615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organic photovoltaic biomaterial with fullerene derivatives for near-infrared light sensing in neural cells. 含富勒烯衍生物的有机光伏生物材料,用于神经细胞的近红外光传感。
IF 1.6 4区 医学
Biointerphases Pub Date : 2024-07-01 DOI: 10.1116/6.0003279
Bowei Yuan, Xue Jiang, Zijun Xie, Xuanjun Zhang, Jiaxin Zhang, Jing Hong
{"title":"Organic photovoltaic biomaterial with fullerene derivatives for near-infrared light sensing in neural cells.","authors":"Bowei Yuan, Xue Jiang, Zijun Xie, Xuanjun Zhang, Jiaxin Zhang, Jing Hong","doi":"10.1116/6.0003279","DOIUrl":"https://doi.org/10.1116/6.0003279","url":null,"abstract":"<p><p>Retinal degenerative diseases, which can lead to photoreceptor cell apoptosis, have now become the leading irreversible cause of blindness worldwide. In this study, we developed an organic photovoltaic biomaterial for artificial retinas, enabling neural cells to detect photoelectric stimulation. The biomaterial was prepared using a conjugated polymer donor, PCE-10, and a non-fullerene receptor, Y6, both known for their strong near-infrared light absorption capabilities. Additionally, a fullerene receptor, PC61BM, was incorporated, which possesses the ability to absorb reactive oxygen species. We conducted a comprehensive investigation into the microstructure, photovoltaic properties, and photothermal effects of this three-component photovoltaic biomaterial. Furthermore, we employed Rat adrenal pheochromocytoma cells (PC-12) as a standard neural cell model to evaluate the in vitro photoelectric stimulation effect of this photovoltaic biomaterial. The results demonstrate that the photovoltaic biomaterial, enriched with fullerene derivatives, can induce intracellular calcium influx in PC-12 cells under 630 nm (red light) and 780 nm (near-infrared) laser irradiation. Moreover, there were lower levels of oxidative stress and higher levels of mitochondrial activity compared to the non-PC61BM group. This photovoltaic biomaterial proves to be an ideal substrate for near-infrared photoelectrical stimulation of neural cells and holds promise for restoring visual function in patients with photoreceptor apoptosis.</p>","PeriodicalId":9053,"journal":{"name":"Biointerphases","volume":"19 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141615800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sequential release of transforming growth factor β1 and fibroblast growth factor 2 from nanofibrous scaffolds induces cartilage differentiation of mouse adipose-derived stem cells. 纳米纤维支架依次释放转化生长因子β1和成纤维细胞生长因子2可诱导小鼠脂肪来源干细胞的软骨分化。
IF 1.6 4区 医学
Biointerphases Pub Date : 2024-07-01 DOI: 10.1116/6.0003687
Yun-Qi Wu, Jun Wang
{"title":"Sequential release of transforming growth factor β1 and fibroblast growth factor 2 from nanofibrous scaffolds induces cartilage differentiation of mouse adipose-derived stem cells.","authors":"Yun-Qi Wu, Jun Wang","doi":"10.1116/6.0003687","DOIUrl":"https://doi.org/10.1116/6.0003687","url":null,"abstract":"<p><p>Once damaged, cartilage has poor intrinsic capacity to repair itself. Current cartilage repair strategies cannot restore the damaged tissue sufficiently. It is hypothesized that biomimetic scaffolds, which can recapitulate important properties of the cartilage extracellular matrix, play a beneficial role in supporting cell behaviors such as growth, cartilage differentiation, and integration with native cartilage, ultimately facilitating tissue recovery. Adipose-derived stem cells regenerated cartilage upon the sequential release of transforming growth factor β1(TGFβ1) and fibroblast growth factor 2(FGF2) using a nanofibrous scaffold, in order to get the recovery of functional cartilage. Experiments in vitro have demonstrated that the release sequence of growth factors FGF2 to TGFβ1 is the most essential to promote adipose-derived stem cells into chondrocytes that then synthesize collagen II. Mouse subcutaneous implantation indicated that the treatment sequence of FGF2 to TGFβ1 was able to significantly induce multiple increase in cartilage regeneration in vivo. This result demonstrates that the group treated with FGF2 to TGFβ1 released from a nanofibrous scaffold provides a good strategy for cartilage regeneration by making a favorable microenvironment for cell growth and cartilage regeneration.</p>","PeriodicalId":9053,"journal":{"name":"Biointerphases","volume":"19 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Building better habitats: Spatiotemporal signaling cues in 3D biointerfaces for tailored cellular functionality. 建设更好的栖息地:三维生物界面中的时空信号提示,实现量身定制的细胞功能。
IF 1.6 4区 医学
Biointerphases Pub Date : 2024-07-01 DOI: 10.1116/6.0003685
Sadegh Ghorbani, Duncan S Sutherland
{"title":"Building better habitats: Spatiotemporal signaling cues in 3D biointerfaces for tailored cellular functionality.","authors":"Sadegh Ghorbani, Duncan S Sutherland","doi":"10.1116/6.0003685","DOIUrl":"10.1116/6.0003685","url":null,"abstract":"<p><p>A promising research direction in the field of biological engineering is the design and functional programming of three-dimensional (3D) biointerfaces designed to support living cell functionality and growth in vitro, offering a route to precisely regulate cellular behaviors and phenotypes for addressing therapeutic challenges. While traditional two-dimensional (2D) biointerfaces have provided valuable insights, incorporating specific signaling cues into a 3D biointeractive microenvironment at the right locations and time is now recognized as crucial for accurately programming cellular decision-making and communication processes. This approach aims to engineer cell-centric microenvironments with the potential to recapitulate complex biological functions into a finite set of growing cellular organizations. Additionally, they provide insights into the hierarchical logic governing the relationship between molecular components and higher-order multicellular functionality. The functional live cell-based microenvironment engineered through such innovative biointerfaces has the potential to be used as an in vitro model system for expanding our understanding of cellular behaviors or as a therapeutic habitat where cellular functions can be reprogrammed.</p>","PeriodicalId":9053,"journal":{"name":"Biointerphases","volume":"19 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug-eluting contact lenses: Progress, challenges, and prospects. 药物洗脱隐形眼镜:进展、挑战和前景。
IF 1.6 4区 医学
Biointerphases Pub Date : 2024-07-01 DOI: 10.1116/6.0003612
Dongdong Gao, Chunxiao Yan, Yong Wang, Heqing Yang, Mengxin Liu, Yi Wang, Chunmei Li, Chao Li, Gang Cheng, Lijun Zhang
{"title":"Drug-eluting contact lenses: Progress, challenges, and prospects.","authors":"Dongdong Gao, Chunxiao Yan, Yong Wang, Heqing Yang, Mengxin Liu, Yi Wang, Chunmei Li, Chao Li, Gang Cheng, Lijun Zhang","doi":"10.1116/6.0003612","DOIUrl":"https://doi.org/10.1116/6.0003612","url":null,"abstract":"<p><p>Topical ophthalmic solutions (eye drops) are becoming increasingly popular in treating and preventing ocular diseases for their safety, noninvasiveness, and ease of handling. However, the static and dynamic barriers of eyes cause the extremely low bioavailability (<5%) of eye drops, making ocular therapy challenging. Thus, drug-eluting corneal contact lenses (DECLs) have been intensively investigated as a drug delivery device for their attractive properties, such as sustained drug release and improved bioavailability. In order to promote the clinical application of DECLs, multiple aspects, i.e., drug release and penetration, safety, and biocompatibility, of these drug delivery systems were thoroughly examined. In this review, we systematically discussed advances in DECLs, including types of preparation materials, drug-loading strategies, drug release mechanisms, strategies for penetrating ocular barriers, in vitro and in vivo drug delivery and penetration detection, safety, and biocompatibility validation methods, as well as challenges and future perspectives.</p>","PeriodicalId":9053,"journal":{"name":"Biointerphases","volume":"19 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141562608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnetic motors in interphases: Motion control and integration in soft robots. 相间磁电机:软体机器人的运动控制与集成。
IF 1.6 4区 医学
Biointerphases Pub Date : 2024-07-01 DOI: 10.1116/6.0003637
Miguel A Ramos Docampo
{"title":"Magnetic motors in interphases: Motion control and integration in soft robots.","authors":"Miguel A Ramos Docampo","doi":"10.1116/6.0003637","DOIUrl":"10.1116/6.0003637","url":null,"abstract":"<p><p>Magnetic motors are a class of out-of-equilibrium particles that exhibit controlled and fast motion overcoming Brownian fluctuations by harnessing external magnetic fields. The advances in this field resulted in motors that have been used for different applications, such as biomedicine or environmental remediation. In this Perspective, an overview of the recent advancements of magnetic motors is provided, with a special focus on controlled motion. This aspect extends from trapping, steering, and guidance to organized motor grouping and degrouping, which is known as swarm control. Further, the integration of magnetic motors in soft robots to actuate their motion is also discussed. Finally, some remarks and perspectives of the field are outlined.</p>","PeriodicalId":9053,"journal":{"name":"Biointerphases","volume":"19 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141589545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of free liquid layer quantity on bacteria and protein adhesion to liquid infused polymers. 游离液层数量对细菌和蛋白质粘附在注入液体的聚合物上的影响。
IF 1.6 4区 医学
Biointerphases Pub Date : 2024-07-01 DOI: 10.1116/6.0003776
ChunKi Fong, Marissa Jeme Andersen, Emma Kunesh, Evan Leonard, Donovan Durand, Rachel Coombs, Ana Lidia Flores-Mireles, Caitlin Howell
{"title":"Effect of free liquid layer quantity on bacteria and protein adhesion to liquid infused polymers.","authors":"ChunKi Fong, Marissa Jeme Andersen, Emma Kunesh, Evan Leonard, Donovan Durand, Rachel Coombs, Ana Lidia Flores-Mireles, Caitlin Howell","doi":"10.1116/6.0003776","DOIUrl":"10.1116/6.0003776","url":null,"abstract":"<p><p>Liquid-infused polymers are recognized for their ability to repel foulants, making them promising for biomedical applications including catheter-associated urinary tract infections (CAUTIs). However, the impact of the quantity of free liquid layer covering the surface on protein and bacterial adhesion is not well understood. Here, we explore how the amount of free silicone liquid layer in infused silicone catheter materials influences the adhesion of bacteria and proteins relevant to CAUTIs. To alter the quantity of the free liquid layer, we either physically removed excess liquid from fully infused catheter materials or partially infused them. We then evaluated the impact on bacterial and host protein adhesion. Physical removal of the free liquid layer from the fully infused samples reduced the height of the liquid layer from 60 μm to below detection limits and silicone liquid loss into the environment by approximately 64% compared to controls, without significantly increasing the deposition of protein fibrinogen or the adhesion of the common uropathogen Enterococcus faecalis. Partially infused samples showed even greater reductions in liquid loss: samples infused to 70%-80% of their maximum capacity exhibited about an 85% decrease in liquid loss compared to fully infused controls. Notably, samples with more than 70% infusion did not show significant increases in fibrinogen or E. faecalis adhesion. These findings suggest that adjusting the levels of the free liquid layer in infused polymers can influence protein and bacterial adhesion on their surfaces. Moreover, removing the free liquid layer can effectively reduce liquid loss from these polymers while maintaining their functionality.</p>","PeriodicalId":9053,"journal":{"name":"Biointerphases","volume":"19 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11324329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tailoring bisphosphonate-doped titanium films to optimally couple cellular responses and antibacterial activity for biomedical applications. 定制掺杂双膦酸盐的钛薄膜,使细胞反应与抗菌活性达到最佳耦合,从而实现生物医学应用。
IF 2.1 4区 医学
Biointerphases Pub Date : 2024-05-01 DOI: 10.1116/6.0003611
Leonardo F G Dias, Raphael C Costa, Catharina M Sacramento, Karina G S Ruiz, Valentim A R Barão, Paulo N Lisboa-Filho
{"title":"Tailoring bisphosphonate-doped titanium films to optimally couple cellular responses and antibacterial activity for biomedical applications.","authors":"Leonardo F G Dias, Raphael C Costa, Catharina M Sacramento, Karina G S Ruiz, Valentim A R Barão, Paulo N Lisboa-Filho","doi":"10.1116/6.0003611","DOIUrl":"https://doi.org/10.1116/6.0003611","url":null,"abstract":"<p><p>Titanium (Ti) is widely utilized as an implant material; nonetheless, its integration with bone tissue faces limitations due to a patient's comorbidities. To address this challenge, we employed a strategic approach involving the growth of thin films by spin-coating and surface functionalization with etidronate (ETI), alendronate (ALE), and risedronate (RIS). Our methodology involved coating of Ti cp IV disks with thin films of TiO2, hydroxyapatite (HA), and their combinations (1:1 and 1:2 v/v), followed by surface functionalization with ETI, ALE, and RIS. Bisphosphonate-doped films were evaluated in terms of surface morphology and physical-chemical properties by techniques such as electron microscopy, confocal microscopy, and x-ray photoelectron spectroscopy. The antibacterial potential of bisphosphonates alone or functionalized onto the Ti surface was tested against Staphylococcus aureus biofilms. Primary human bone mesenchymal stem cells were used to determine in vitro cell metabolism and mineralization. Although RIS alone did not demonstrate any antibacterial effect as verified by minimum inhibitory concentration assay, when Ti surfaces were functionalized with RIS, partial inhibition of Staphylococcus aureus growth was noted, probably because of the physical-chemical surface properties. Furthermore, samples comprising TiO2/HA (1:1 and 1:2 v/v) showcased an enhancement in the metabolism of nondifferentiated cells and can potentially enhance the differentiation of osteoblastic precursors. All samples demonstrated cell viability higher than 80%. Addition of hydroxyapatite and presence of bisphosphonates increase the metabolic activity and the mineralization of human bone mesenchymal cells. While these findings hold promise, it is necessary to conduct further studies to evaluate the system's performance in vivo and ensure its long-term safety. This research marks a significant stride toward optimizing the efficacy of titanium implants through tailored surface modifications.</p>","PeriodicalId":9053,"journal":{"name":"Biointerphases","volume":"19 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141246882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sum-frequency vibrational spectroscopy, a tutorial: Applications for the study of lipid membrane structure and dynamics. 和频振动光谱学教程:脂膜结构和动力学研究的应用。
IF 2.1 4区 医学
Biointerphases Pub Date : 2024-05-01 DOI: 10.1116/6.0003594
Joshua M Taylor, John C Conboy
{"title":"Sum-frequency vibrational spectroscopy, a tutorial: Applications for the study of lipid membrane structure and dynamics.","authors":"Joshua M Taylor, John C Conboy","doi":"10.1116/6.0003594","DOIUrl":"10.1116/6.0003594","url":null,"abstract":"<p><p>Planar supported lipid bilayers (PSLBs) are an ideal model for the study of lipid membrane structures and dynamics when using sum-frequency vibrational spectroscopy (SFVS). In this paper, we describe the construction of asymmetric PSLBs and the basic SFVS theory needed to understand and make measurements on these membranes. Several examples are presented, including the determination of phospholipid orientation and measuring phospholipid transmembrane translocation (flip-flop).</p>","PeriodicalId":9053,"journal":{"name":"Biointerphases","volume":"19 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140911077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced bactericidal performance of textiles through compound antimicrobial agents. 通过复合抗菌剂提高纺织品的杀菌性能。
IF 1.6 4区 医学
Biointerphases Pub Date : 2024-05-01 DOI: 10.1116/6.0003710
Yi Huang, Ying Li, Kai-Bo Chen, Hang Zhang
{"title":"Enhanced bactericidal performance of textiles through compound antimicrobial agents.","authors":"Yi Huang, Ying Li, Kai-Bo Chen, Hang Zhang","doi":"10.1116/6.0003710","DOIUrl":"https://doi.org/10.1116/6.0003710","url":null,"abstract":"<p><p>This study aims to explore the essential functional requirements associated with controlling the proliferation of microbes in the domain of textiles used in public health areas. Herein, three antimicrobial agents, specifically iodopropylbutylcarbamate (IPBC), 1-hydroxypyridine-2-thioketone zinc (ZPT), and 2-octyl-3-isothiazolinone (OIT), were chosen for fabric finishing based on their notable effectiveness, minimal toxicity, cost-efficiency, and chemical stability. Utilizing Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) as representative bacterial strains, the Minimum Inhibitory Concentration (MIC50) of individual and combined antimicrobial agents was measured, and their antimicrobial effectiveness was rigorously evaluated. Concurrently, the antimicrobial effectiveness, whiteness, and mechanical durability of the fabric following antimicrobial treatment were thoroughly examined. The results demonstrate that some combinations of the three antimicrobial agents elicit additive effects on both S. aureus and E. coli. Notably, at an equivalent ratio of IPBC, ZPT, and OIT and a total concentration of 0.2 wt. %, the inhibition rates against both bacterial strains surpass 99%. Upon application to nylon fabric, the treated material demonstrates significant antimicrobial properties, with minimal reduction observed in the whiteness and tensile strength of the treated nylon. This study provides practicable strategies relevant to the production of textiles endowed with antimicrobial properties.</p>","PeriodicalId":9053,"journal":{"name":"Biointerphases","volume":"19 3","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141455263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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