BMC Psychiatry最新文献

{"title":"Maintenance pharmacotherapy after electroconvulsive therapy in inpatients with major depressive disorder: 198 prescriptions in a real-world clinical setting.","authors":"Shun Igarashi, Takashi Tsuboi, Naomi Hasegawa, Shinichiro Ochi, Kazutaka Ohi, Kentaro Fukumoto, Jun-Ichi Iga, Hiroyuki Muraoka, Hitoshi Iida, Fumitoshi Kodaka, Shusuke Numata, Kayo Ichihashi, Hiroko Kashiwagi, Toshinori Nakamura, Hirotaka Yamagata, Masahiro Takeshima, Tatsuya Nagasawa, Junya Matsumoto, Hisashi Yamada, Hikaru Hori, Ken Inada, Norio Yasui-Furukori, Ryota Hashimoto, Koichiro Watanabe","doi":"10.1186/s12888-025-07445-4","DOIUrl":"10.1186/s12888-025-07445-4","url":null,"abstract":"<p><strong>Background: </strong>Although antidepressant monotherapy is recommended for patients with major depressive disorder (MDD), they often do not respond to it, necessitating alternatives such as electroconvulsive therapy (ECT). However, maintenance pharmacotherapy after ECT has remained unestablished. This study, conducted at 240 facilities throughout Japan, aimed to explore maintenance pharmacotherapy after ECT for 3,749 inpatients with MDD.</p><p><strong>Methods: </strong>The patients were divided into two groups, one that underwent ECT (ECT group, N = 521) and another that did not (non-ECT group, N = 3,273), for the comparison of clinical characteristics and prescription details at discharge. The primary outcome of this study was the prescription rate of antidepressant monotherapy at discharge, while the secondary outcomes included prescription rates of specific combination regimens, such as antidepressant plus lithium.</p><p><strong>Results: </strong>We identified 198 prescription patterns involving antidepressants in the ECT group. Analysis by drug category revealed distinctive patterns: there was no statistically significant difference in prescription rates for antidepressant monotherapy between the ECT and non-ECT groups (N = 118, 22.6% vs. N = 932, 28.4%). In contrast, the prescription rate for the combination of antidepressant and antipsychotic medications was significantly higher in the ECT group (N = 188, 36.0% vs. N = 941, 28.7%). The combination of antidepressant and mood stabilizer was also more frequent in the ECT group (N = 35, 6.7% vs. N = 130, 3.9%), although this difference did not reach statistical significance after Bonferroni correction. At the drug level, additional distinctive patterns emerged: among antidepressant monotherapies, nortriptyline use was significantly more common in the ECT group (N = 9, 1.7% vs. N = 11, 0.3%). For mood stabilizers, restricting the analysis to lithium revealed a markedly higher rate in the ECT group (N = 30, 5.7% vs. N = 35, 1.0%).</p><p><strong>Conclusions: </strong>These findings highlight the complexity of treatment decisions managing of MDD after ECT and emphasize the need for structured prospective research on the effectiveness of specific maintenance pharmacotherapies after ECT.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"957"},"PeriodicalIF":3.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden and prediction study of schizophrenia 1990-2030: comparison with China.","authors":"Zhou Yuan, Chen Bai, Yue Li, Jin Zhang, Ping Yu, Fei Jiang","doi":"10.1186/s12888-025-07168-6","DOIUrl":"10.1186/s12888-025-07168-6","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to assess and predict global and Chinese schizophrenia burden trends from 1990 to 2030.</p><p><strong>Methods: </strong>Retrieve data from the 2021 Global Burden of Disease Study to estimate the incidence, prevalence, and disability-adjusted life years (DALYs) of schizophrenia from 1990 to 2021. Establish a joint point analysis and Bayesian age-period-cohort (BAPC) model to predict the burden of schizophrenia in 2030.</p><p><strong>Result: </strong>In 2021, the global prevalence of schizophrenia was approximately 13.60 million cases, with an age-standardized rate of 275.78 per 100,000 population. The global incidence was around 1.2 0million cases, with a rate of 15.43 per 100,000, and the global DALYs totaled 14.80 million, with a rate of 177.75 per 100,000. In China, the prevalence was about 5.30 million cases (300.81 per 100,000), the incidence was 236,175 cases (18.36 per 100,000), and DALYs were 3.40 million (203.88 per 100,000). From 1990 to 2021, China's age-standardized prevalence and DALY rates increased, with estimated annual percentage change (EAPCs) of 0.12 and 0.04. However, the global age-standardized incidence rate also decreased, with an EAPC of -0.04. Using the BAPC model, forecasts indicate a rising trend in both global and Chinese schizophrenia prevalence, incidence, and DALYs from 2020 to 2030. By 2030, the global age-standardized prevalence, incidence, and DALYs are projected to reach 280.36, 15.59, and 177.31 per 100,000, respectively. In China, these rates are expected to reach 332.58, 19.87, and 216.67 per 100,000.</p><p><strong>Conclusion: </strong>The global burden of schizophrenia is increasing, particularly in China, where the trend is especially pronounced. In response to this trend, Mental health education and early identification measures should be promoted for high-burden populations, especially young adults aged 20-34, while mental health support services for men should be strengthened and more gender-sensitive treatment and rehabilitation pathways should be designed. As future burden projections continue to rise, policymakers should optimize resource allocation, accordingly, incorporate research data into mental health planning, and improve accessibility and equity of services for key populations, in order to promote more targeted intervention strategies and effectively alleviate the social and family burden of schizophrenia.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"955"},"PeriodicalIF":3.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subregional amygdala functional connectivity abnormalities and anhedonia impairments in first-episode schizophrenia.","authors":"Qijie Kuang, Sumiao Zhou, Guangxing Deng, Nvnan Zhou, Xiangzhu Zeng, Hengyu Zhang, Yongjie Deng, Yingjun Zheng, Shenglin She","doi":"10.1186/s12888-025-07363-5","DOIUrl":"10.1186/s12888-025-07363-5","url":null,"abstract":"<p><strong>Background: </strong>Although abnormal amygdala functional connectivity (FC) has been reported in schizophrenia, most studies have treated the amygdala as a single structure. This study aimed to explore the association between amygdala subregional FC and anhedonia in patients with first-episode schizophrenia (FES).</p><p><strong>Methods: </strong>Resting-state functional magnetic resonance imaging (fMRI) was conducted in 31 FES patients (including 11 drug-naïve) and 33 matched healthy controls (HCs). Clinical symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS), and anhedonia was evaluated via the Snaith-Hamilton Pleasure Scale (SHAPS). Whole-brain FC analyses of amygdala subregions were performed, followed by group comparisons and correlation analyses with anhedonia scores.</p><p><strong>Result: </strong>Compared to HCs, FES patients showed significantly reduced FC between specific amygdala subregions and cortical regions, particularly within the frontal, temporal, parietal, and limbic lobes (P < 0.05, GRF correction). Anhedonia severity was positively correlated with altered FC in the centromedial (CM) subregion of the amygdala (AMY_CM), especially with the supplementary motor area (SMA) and paracentral lobule (PLG). Notably, the association between right AMY_CM and right SMA FC and anhedonia remained significant after adjusting for clinical symptom severity (r = 0.46, P = 0.02).</p><p><strong>Conclusions: </strong>FES patients exhibit disrupted FC between amygdala subregions and cortical areas, with specific patterns linked to anhedonia. These findings suggest that anhedonia may be associated with a potential neurobiological marker independent of general clinical symptoms and may be indicative of amygdala-cortical dysconnectivity in schizophrenia.</p><p><strong>Trial registration: </strong>Data used for this analysis came from case-control studies.</p><p><strong>Clinical trial number: </strong>not applicable. (April 2018 through March 2021).</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"960"},"PeriodicalIF":3.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating pain and pleasure: trauma and alcohol use among urban women in India.","authors":"Krisha Balsarkar, Ketoki Mazumdar","doi":"10.1186/s12888-025-07326-w","DOIUrl":"10.1186/s12888-025-07326-w","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"961"},"PeriodicalIF":3.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of different forms of single moderate-intensity exercise on inhibitory function and instant emotion of undergraduate students with depressive symptoms: a randomized controlled trial based on ERP.","authors":"Feng Gao, Shuqi Jia, Suowang Yin, Zhaosong Yin, Wei Guan, Feng Ding, Xing Wang, Ping Wan","doi":"10.1186/s12888-025-07310-4","DOIUrl":"10.1186/s12888-025-07310-4","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"950"},"PeriodicalIF":3.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CATATOnia treatment with transcranial direct current electrostimulation: protocol of a randomised, double-blind, placebo-controlled bicentric superiority study (CATATOES).","authors":"Mylène Moyal, David Attali, Alice Le Berre, Noomane Bouaziz, Anton Iftimovici, François Ramon, Adèle Henensal, Louise Dahan, Laetitia Canivet, Ghita Dadi, Clément Debacker, Maliesse Lui, Sylvain Charron, Anaëlle Alouit, Khaoussou Sylla, Rossella Letizia Mancusi, Thierry Gallarda, Arnaud Cachia, Martine Gavaret, Boris Chaumette, Catherine Oppenheim, Dominique Januel, Marion Plaze, Alexandre Haroche","doi":"10.1186/s12888-025-07266-5","DOIUrl":"10.1186/s12888-025-07266-5","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"949"},"PeriodicalIF":3.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of and factors associated with unintended pregnancy and association with depressive symptoms among pregnant women in Guangdong, China: a multicentre cross-sectional study.","authors":"Yaqin Gao, Yuying Wang, Fanyan Huang, Haiyan Liu, Muyao Wang, Chen Mao, Yu Chen","doi":"10.1186/s12888-025-07315-z","DOIUrl":"10.1186/s12888-025-07315-z","url":null,"abstract":"<p><strong>Background: </strong>Limited attention has been paid to the characteristics of unintended pregnancy and prenatal depressive symptoms in China. This study aimed to explore the prevalence of and factors associated with unintended pregnancy and their impact on depressive symptoms among pregnant women in Guangdong, China.</p><p><strong>Methods: </strong>A multicentre cross-sectional study was conducted among pregnant women attending routine antenatal care at five tertiary hospitals in Guangdong between February and July 2022. Pregnancy intention was assessed using a dichotomous question, and prenatal depressive symptoms were evaluated with the Edinburgh Postpartum Depression Scale (EPDS). Binary logistic regression was used to analyse the association between them. Stratified and sensitivity analyses were performed to test the robustness of the results.</p><p><strong>Results: </strong>A total of 2120 pregnant women were included in the study, with an overall prevalence of unintended pregnancy of 34.6%. Factors associated with an increased risk of unintended pregnancy included being unemployed (OR = 1.43, 95%CI = 1.05-1.96), while factors associated with a decreased risk included: being 30-34 years old (OR = 0.73, 95%CI = 0.54-0.99), having siblings (OR = 0.60, 95%CI = 0.44-0.81), being married (OR = 0.31, 95%CI = 0.16-0.60), having a postgraduate degree (OR = 0.29, 95%CI = 0.14-0.59), not drinking alcohol (OR = 0.41, 95%CI = 0.23-0.74), and having never given birth (OR = 0.46, 95%CI = 0.37-0.56). After controlling for confounders, unintended pregnancy still had an impact on prenatal depressive symptoms (adjusted OR = 1.26, 95%CI = 1.03-1.52), more pronounced in pregnant women aged 20-29.</p><p><strong>Conclusions: </strong>Targeted screening for unintended pregnancy based on these associated factors and mental health support for high-risk groups could mitigate the risk of prenatal depressive symptoms.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"954"},"PeriodicalIF":3.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12509406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nocturnal hypoxia moderates the relationship between rapid eye movement sleep and anxiety.","authors":"Fei Jiang, Tianbai Li, Jinsong Huang, Lijun Fan, Wenzhu Zhou, Weidong Le, Gang Zhu","doi":"10.1186/s12888-025-07440-9","DOIUrl":"10.1186/s12888-025-07440-9","url":null,"abstract":"<p><strong>Objective: </strong>Sleep problems, especially rapid eye movement sleep disturbances, are associated with various neurological and psychological disorders. Given the potential of nocturnal hypoxia to induce psychological symptoms, we investigated its moderating effect on the relationship between sleep variables and psychological symptoms among individuals with sleep disturbances.</p><p><strong>Methods: </strong>A total of 160 participants who complained of sleep problems were enrolled, and their hypoxic and sleep indices were recorded using overnight polysomnography. The psychological status of all participants was further assessed using Symptom Checklist-90-R (SCL-90-R, Chinese version). Hierarchical regression analyses were employed to examine the influence of hypoxic indices and sleep indices, and the interaction of these variables on psychological symptoms. Simple slope analyses were used to probe significant interactions.</p><p><strong>Results: </strong>Hierarchical regression analyses indicated that the cumulative duration of nocturnal hypoxia (SpO₂ < 95%) moderated the relationship between the percentage of rapid eye movement sleep (RT%) and psychological symptoms (somatization, obsessive compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, and psychoticism). To account for the increased risk of Type I errors due to multiple statistical tests, we applied False Discovery Rate correction. After applying the FDR correction, the p-value for the cumulative duration of nocturnal hypoxia (SpO₂ < 95%) in moderating the relationship between RT% and anxiety remained significant (β = 0.312, △ F = 16.586, p < 0.01, 95% confidence interval [0.009, 0.025]).</p><p><strong>Conclusion: </strong>Our study demonstrates that nocturnal hypoxia, particularly the cumulative duration of hypoxia (SpO₂ < 95%), moderates the association between RT% and anxiety symptoms. These findings indicate a potential interaction between rapid eye movement sleep and nocturnal hypoxia in relation to psychological symptoms. Further research is warranted to clarify the underlying mechanisms.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"952"},"PeriodicalIF":3.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic function is associated with cognitive function in patients with stable schizophrenia.","authors":"Jian Han, Xiu Li, Yanping Feng, Yan Guo, Binyou Wang, Yilin Wang","doi":"10.1186/s12888-025-07448-1","DOIUrl":"10.1186/s12888-025-07448-1","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"948"},"PeriodicalIF":3.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived teacher support moderate the relationships between adverse childhood experiences and social adjustment among migrant children: a latent profile analysis.","authors":"Fang Wang, Xiaofeng Ma","doi":"10.1186/s12888-025-07179-3","DOIUrl":"10.1186/s12888-025-07179-3","url":null,"abstract":"<p><strong>Background: </strong>Adverse childhood experiences (ACEs) correlate with social adjustment. Notwithstanding the rising incidence of ACEs within migrant populations, there is a shortage of studies investigating ACEs patterns and the associated risk for social adjustment in migrant children.</p><p><strong>Objective: </strong>The research seeks to examine the correlation between ACEs and social adjustment, and to investigate whether perceived teacher support moderates this relationship.</p><p><strong>Methods: </strong>A total of 821 migrant children (M_age = 13.5 years, age range 11to 16 years) living in Lanzhou were recruited from three junior middle schools between September and November 2023. They were evaluated with the 28-item Childhood Trauma Questionnaire (CTQ-SF), Perceived Teacher Support Scale and Adolescents' Social Adjustment Assessment Scale. Latent profile and moderated analysis were conducted.</p><p><strong>Results: </strong>Three profiles of adverse childhood experiences were founded and labeled as Low (15.6%), Medium (32.7%), and High (6.7%). There is variability in ACEs among migrant children. The link between adverse childhood experiences and social adjustment is significantly moderated by perceived teacher support. ACEs are prevalent among migrant children and are associated with decreased odds of social adjustment, especially among those with low perceived teacher support.</p><p><strong>Conclusions: </strong>Our findings highlight the need for interventions aimed at implemented to prevent ACEs and family- and school-based interventions can be provided to develop positive experiences among migrant children.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"951"},"PeriodicalIF":3.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}