BMC PsychiatryPub Date : 2025-07-01DOI: 10.1186/s12888-025-07099-2
Arzu Karakaya, Guzel Nur Yıldız, Nuray Şimşek
{"title":"Development of the scale on the effects of sleep disorder on stress: validity and reliability study.","authors":"Arzu Karakaya, Guzel Nur Yıldız, Nuray Şimşek","doi":"10.1186/s12888-025-07099-2","DOIUrl":"https://doi.org/10.1186/s12888-025-07099-2","url":null,"abstract":"<p><strong>Background: </strong>The relationship between sleep disorders and cognitive stress in clinical psychology, especially from the perspective of Beck's Cognitive Theory, holds critical importance. The current measurement tools do not adequately assess the cognitive components of sleep-related stress (e.g., automatic thoughts, cognitive distortions), highlighting the need for a new instrument in this field. Specifically, quantitatively evaluating the effects of insomnia on an individual's perception of the future, self-esteem, and worldview is fundamental for clinical interventions.</p><p><strong>Purpose: </strong>This study aims to develop a valid and reliable scale capable of measuring stress caused by sleep disorders with a multidisciplinary approach, based on Beck's Cognitive Theory's \"cognitive triad\" (perception of future/self/world) and the concept of cognitive distortion.</p><p><strong>Method: </strong>The study was conducted with 637 participants who had a Pittsburgh Sleep Quality Index (PSQI) score of ≥ 5. Data were collected using the Pittsburgh Sleep Quality Index, the Perceived Stress Scale, and a draft scale. Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA) were used to assess construct validity, while Cronbach's Alpha (α) and McDonald Omega (ω) were used for reliability analysis.</p><p><strong>Results: </strong>The results of the exploratory and confirmatory factor analyses revealed that the scale consists of two main dimensions: (1) Cognitive Distortions dimension (10 items, α = 0.952), which measures automatic negative thoughts such as \"When I feel inadequate in any aspect due to sleep disorder\" experienced by participants during sleep deprivation. (2) Cognitive Triad dimension (8 items, α = 0.925), which reflects disruptions in perceptions of the future, self, and the world (environment), with statements like \"On days when I experience sleep disorders, I feel like my appearance looks bad.\" The overall reliability coefficients of the scale were found to be α = 0.964 and ω = 0.961. The developed scale was found to have a positive correlation with the Pittsburgh Sleep Quality Index, Perceived Stress Scale, and VAS. CONCLUSıONS: The developed scale is the first tool to clinically and meaningfully reveal the cognitive stress mechanisms caused by sleep disorders. Its structure, directly aligning with the core components of Beck's Cognitive Theory, increases the potential for its use in cognitive-behavioral therapy protocols. Furthermore, the methodological framework it provides for cross-cultural validity studies lays the groundwork for comparative research on a global scale.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"658"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC PsychiatryPub Date : 2025-07-01DOI: 10.1186/s12888-025-06956-4
Fatima Q Alshaikhmubarak, Richard N Keers, Petra Brown, Penny J Lewis
{"title":"Exploring current approaches towards patient prioritisation for clinical pharmacy services in UK mental health inpatient care.","authors":"Fatima Q Alshaikhmubarak, Richard N Keers, Petra Brown, Penny J Lewis","doi":"10.1186/s12888-025-06956-4","DOIUrl":"https://doi.org/10.1186/s12888-025-06956-4","url":null,"abstract":"<p><strong>Background: </strong>Mental health services in the United Kingdom (UK) are experiencing heightened pressures due to an increase in the number of patients accessing secondary mental health services amidst a period of workforce and funding constraints. Patient prioritisation for inpatient clinical pharmacy services is a promising approach to delivering optimal services with limited available resources. Research has identified several patient prioritisation tools used by acute care pharmacists across the UK, yet little is known about the use of pharmaceutical patient prioritisation approaches in mental health settings. Therefore, this study aimed to explore patient prioritisation approaches used by UK inpatient mental health pharmacy teams.</p><p><strong>Method: </strong>An electronic national questionnaire was distributed among chief/senior pharmacists within all UK mental health organisations to identify the use of patient prioritisation systems (tools or processes). This was followed by semi-structured interviews with representative members from organisations that responded to the questionnaire and reported using prioritisation systems, and document analysis for prioritisation systems if shared. Interviews were transcribed and analysed using thematic analysis as described by Braun & Clarke. Ethical approval was obtained from the University of Manchester Ethics Committee.</p><p><strong>Results: </strong>A 75.3% (n = 55/73) response rate was achieved for the questionnaire between July 2022 and January 2023. Of organisations that completed the questionnaire, 38.2% (n = 21/55) used a prioritisation system within their inpatient pharmacy services in England (n = 14/21), Scotland (n = 6/21), and Northern Ireland (n = 1/21). Sixteen staff representatives from 15 organisations reporting the use of prioritisation systems were interviewed, and 11 prioritisation documents were received and analysed. Prioritisation systems varied greatly in their complexity and development approaches, and the majority were simplistic in design, developed solely based on existing expertise, and lacked formal evaluation. However, all prioritisation systems were perceived by staff to be beneficial in improving patient safety, standardising care, and optimising clinical pharmacy services. Prioritisation criteria included some high-risk medicines (e.g. lithium), issues related to mental health legislation, and patient related factors such as swallowing difficulties.</p><p><strong>Conclusion: </strong>This study identified 21 UK-based mental health organisations using systems to prioritise inpatients for clinical pharmacy services. Patient prioritisation systems were reported to be beneficial for pharmacy teams in managing their workload and delivering services despite their reported limitations. However, interviews with a single representative may not fully capture the perspectives and experiences of others.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"617"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC PsychiatryPub Date : 2025-07-01DOI: 10.1186/s12888-025-07101-x
Elin Anita Fadum, Øivind Ekeberg, Erlend Hem
{"title":"Job satisfaction in doctors with suicidal ideation: a national longitudinal panel study 2002-2021.","authors":"Elin Anita Fadum, Øivind Ekeberg, Erlend Hem","doi":"10.1186/s12888-025-07101-x","DOIUrl":"https://doi.org/10.1186/s12888-025-07101-x","url":null,"abstract":"<p><strong>Background: </strong>This study examined the relationship between doctors' job satisfaction over time and suicidal ideation, additionally describing job satisfaction in doctors who reported suicidal planning and attempt(s).</p><p><strong>Methods: </strong>A national panel of Norwegian doctors was surveyed between 2002 and 2021 using Warr's Job Satisfaction Scale (JSS) in 2002-2021, Maslach Burnout Inventory (MBI) in 2019/2021 and Paykel's questionnaire for suicidal ideation in 2021. We included 1470 participating doctors in 2021 using multivariate logistic regression models to assess JSS and dimensions of MBI on suicidal ideation.</p><p><strong>Results: </strong>Doctors with suicidal ideation (16%) scored on average 4.5 points lower on JSS (95% confidence interval (CI) -6.1 to -2.9) in 2019 with 7.2 points higher values of emotional exhaustion than the reference group (95% CI 5.4 to 9.1). Doctors with suicidal ideation consistently reported less job satisfaction in the period 2002-2021. In multivariate models, less JSS, higher values of emotional exhaustion and lower values of personal accomplishment remained predictors for suicidal ideation, whereas being in a relationship was a protective factor. Lifetime prevalence of suicidal planning and attempt(s) were 8.2% and 1.2%, respectively. Doctors with such suicidal behaviour had the highest values of emotional exhaustion in 2021 (32.1, 95% CI 29.5 to 34.8), but few stated work-problems as the main reason for a suicide attempt.</p><p><strong>Conclusions: </strong>Doctors with suicidal ideation had less job satisfaction over a 20-year period prior to their suicidal ideation reports. Doctors with suicidal behaviour had the highest values of emotional exhaustion<sub>,</sub> but work problems were rarely reported as the main reason for a suicide attempt.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"666"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC PsychiatryPub Date : 2025-07-01DOI: 10.1186/s12888-025-07082-x
Qing-Zhong Li, Jia-Xin Tan, Guo-Tian Ruan, Quan-Zhi Qin, Teng Deng, Yi-Zhen Gong
{"title":"NHANES 2005-2018 data reveal high albumin-bilirubin scores are associated with depression.","authors":"Qing-Zhong Li, Jia-Xin Tan, Guo-Tian Ruan, Quan-Zhi Qin, Teng Deng, Yi-Zhen Gong","doi":"10.1186/s12888-025-07082-x","DOIUrl":"https://doi.org/10.1186/s12888-025-07082-x","url":null,"abstract":"<p><strong>Background: </strong>Depression has been recognized as a leading global contributor to disease burden and mortality. While the etiology of depression involves a complex interplay of biological, psychological, and social factors, its precise pathophysiological mechanisms remain incompletely understood. The albumin-bilirubin (ALBI) score, originally developed as an objective measure of hepatic function, has demonstrated prognostic value in diverse clinical contexts including liver diseases, brain tumors and chronic heart failure. However, the relationship between ALBI scores and depression has not been systematically investigated. This study aims to examine the association between ALBI scores and depression in a nationally representative cohort.</p><p><strong>Methods: </strong>This population-based cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning seven survey cycles (2005-2018). The ALBI score was calculated using the established formula: ALBI = (log10 bilirubin [μmol/L] × 0.66) + (albumin [g/L] × -0.085). Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9). Weighted multivariable logistic regression models were constructed to analyze the association between ALBI and depression, adjusting for potential covariates. Nonlinear relationships were explored using restricted cubic splines (RCS). The robustness of the results was validated through subgroup analyses. The relationship between ALBI and depression symptoms severity was evaluated via ANOVA. For prognostic analysis, Cox proportional hazards regression models assessed the link between ALBI and clinical outcomes, complemented by Kaplan-Meier (K-M) survival curves and RCS plots to illustrate trends.</p><p><strong>Results: </strong>Weighted multivariable logistic regression models revealed a significant association between elevated ALBI scores and depression risk. Participants in the higher ALBI (ALBI≧ -2.87) demonstrated 16% increased odds of depression compared to the reference (ALBI < -2.87) (adjusted OR = 1.16, 95% CI 1.03-1.31, P = 0.01). Restricted cubic spline analysis confirmed a linear relationship between continuous ALBI scores and depression risk. Subgroup analyses stratified by age, gender, race, education, smoking, drinking and diabetes consistently identified high ALBI as an independent risk factor for depression. The analysis of variance revealed a significant dose-response relationship between ALBI and depression symptom severity (P < 0.05). Cox proportional hazards models revealed significant associations between ALBI increments and mortality risks in the depression cohort. For all-cause mortality, each 1-unit ALBI elevation was associated with a 284% increased risk (adjusted HR = 3.84, 95% CI 2.77-5.33, P < 0.01). Cancer-related mortality showed a 235% risk escalation per ALBI unit (HR = 3.35, 95% CI 1.54-7.26, P < 0.01), while non-cancer deaths exhibited an stronger association at 296% i","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"660"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC PsychiatryPub Date : 2025-07-01DOI: 10.1186/s12888-025-07048-z
Chunhong Yang, Zhuohui Zhou, Qiping Li, Ao Zhao, Chao Chen, Chunyang Li
{"title":"Changes in olfactory function and serum interleukin-6 levels in the acute phase of bipolar I disorder: a longitudinal study.","authors":"Chunhong Yang, Zhuohui Zhou, Qiping Li, Ao Zhao, Chao Chen, Chunyang Li","doi":"10.1186/s12888-025-07048-z","DOIUrl":"https://doi.org/10.1186/s12888-025-07048-z","url":null,"abstract":"<p><strong>Objectives: </strong>In this study, we horizontally compared olfactory function and interleukin-6 levels in bipolar disorder (BD) patients with manic and depressive episodes with those in healthy controls. We also compared these variables longitudinally between patients in the acute versus euthymic phase, and assessed the correlation between olfactory function and interleukin-6 in BD patients overall. The purpose of this study was to search potential biomarkers for early diagnosis and efficacy evaluation of BD, and to provide more clinical evidence for exploring the hypothesis of neuroimmune pathways in BD.</p><p><strong>Methods: </strong>The study included 50 manic BD patients, 31 depressive BD patients, and 59 healthy controls, and all patients were followed until they entered the euthymic phase. Olfactory sensitivity (OS) and olfactory identification (OI) were evaluated via the Sniffin' Sticks test. We collected blood samples and measured serum interleukin-6 levels.</p><p><strong>Results: </strong>The results showed that the OS and OI in manic BD group and depressive BD group were significantly lower than those in healthy controls (P < 0.05, Cohen's d = 0.657, 0.446, η<sup>2</sup> = 0.744, 0.676, respectively), and the OI in euthymic manic BD group and euthymic depressive BD group were significantly lower than those in healthy controls (P < 0.0167, η<sup>2</sup> = 0.72, 0.653, respectively). OS returned to normal levels with remission of the disease (P < 0.0167, η<sup>2</sup> = 12.106), while OI was continuously impaired. Serum interleukin-6 decreased with remission in manic BD (P = 0.038, η<sup>2</sup> = 12.118), but did not return to normal levels (P = 0.006, η<sup>2</sup> = 0.719). OS was negatively correlated with serum interleukin-6 in manic BD patients (r = -0.386, P = 0.006).</p><p><strong>Conclusion: </strong>The dynamic recovery of OS (impaired in acute phase, restored in euthymia) suggests its potential as a disease-activity biomarker in BD, while persistent OI deficits may reflect trait-related neurobiological features. However, their specificity and clinical utility require rigorous validation. There is a potential correlation between inflammatory activity and olfactory dysfunction in manic BD patients, but its causal relationship and specific mechanism need to be further verified.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"605"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC PsychiatryPub Date : 2025-07-01DOI: 10.1186/s12888-025-06885-2
Fangbo Lin, Meiyun Zhou
{"title":"Establishment and validation of a model for predicting depression risk in stroke patients.","authors":"Fangbo Lin, Meiyun Zhou","doi":"10.1186/s12888-025-06885-2","DOIUrl":"https://doi.org/10.1186/s12888-025-06885-2","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to develop and validate a clinically applicable nomogram to predict depression risk in stroke patients by integrating multidimensional predictors from rehabilitation assessments, biochemical markers, and lifestyle metrics.</p><p><strong>Methods: </strong>Using data from 767 stroke patients (training/testing: 363/242; external validation: 162) in the CHARLS database and the First Hospital of Changsha, the Least Absolute Shrinkage and Selection Operator (LASSO) regression identified five predictors: Activities of Daily Living (ADL), Instrumental Activities of Daily Living (IADL), sleep (optimal: 6-8 h), uric acid, and Triglyceride-Glucose-Body Mass Index (TyG-BMI). Multivariable logistic regression constructed the nomogram, validated through ROC analysis (AUC), calibration curves, decision curve analysis (DCA), and SHapley Additive exPlanations (SHAP).</p><p><strong>Results: </strong>The nomogram demonstrated moderate to strong discrimination, with AUC values of 0.731 (training), 0.663 (testing), and 0.748 (external validation). Calibration plots confirmed high predictive accuracy, while DCA revealed substantial clinical utility. SHAP analysis ranked sleep (protective) and ADL (risk) as top contributors. Lower uric acid and TyG-BMI correlated with higher depression risk, contrasting prior studies on TyG-BMI.</p><p><strong>Conclusions: </strong>This model enables rapid, cost-effective depression risk stratification using routine clinical data, prioritizing high-risk stroke patients for early intervention. Despite limitations (single-country data, unaddressed stroke subtypes), it bridges predictive analytics and clinical workflows, emphasizing sleep hygiene, metabolic monitoring, and functional rehabilitation.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"668"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC PsychiatryPub Date : 2025-07-01DOI: 10.1186/s12888-025-06763-x
Olga Bayar-Kapıcı, Yaşar Kapıcı, Dilek Örüm, Mehmet Hamdi Örüm, Mehmet Şirik
{"title":"Hippocampus alterations in post-traumatic stress disorder among survivors of the consecutive Kahramanmaraş (Turkey) earthquakes in February 6, 2023: earthquake brain at the end of the first year.","authors":"Olga Bayar-Kapıcı, Yaşar Kapıcı, Dilek Örüm, Mehmet Hamdi Örüm, Mehmet Şirik","doi":"10.1186/s12888-025-06763-x","DOIUrl":"https://doi.org/10.1186/s12888-025-06763-x","url":null,"abstract":"<p><strong>Background: </strong>On February 6, 2023, a series of earthquakes resulted in approximately 60,000 deaths and 120,000 injuries in Turkey and Syria. These earthquakes caused serious psychological problems in addition to their social and economic effects. Post-traumatic stress disorder (PTSD) is one of the most frequently reported psychiatric disorder among the survivors of earthquakes. The aim of this study is to investigate the hemispheric asymmetries and volumes of hippocampus and amygdala of survivors under treatment with a diagnosis of earthquake-exposed PTSD (PTSD group) with earthquake-exposed subjects without a diagnosis of PTSD (non-PTSD group) one year after the Kahramanmaraş earthquakes.</p><p><strong>Methods: </strong>PTSD subjects (n = 39, 17 females and 22 males) who had been using antidepressants for 6-12 months and matched (age, gender, education, smoking, menstrual cycle phase) non-PTSD subjects (n = 42, 21 females and 21 males) from hospital staff were retrospectively included in the study based on filtering criteria. Sociodemographic and clinical data were obtained through the patient registration system. The scores of the PTSD Checklist for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Beck Depression Inventory, and Beck Anxiety Inventory administered to PTSD subjects and the Symptom Checklist-90-Revised (SCL-90-R) administered to all subjects at admission were recorded. Imaging of hippocampus and amygdala was performed with a 1.5-tesla MRI scanner and loaded into software that automatically analysed the segments. SPSS version 26.0 was used for the statistical analysis (descriptive, regression, correlation, receiver operating characteristic, multiple testing correction). A value less than 0.05 was considered statistically significant.</p><p><strong>Results: </strong>While the groups were similar regarding history of major depressive disorder (p = 0.850) and anxiety disorder (p = 0.590), PTSD history in 1st degree relative (p = 0.005) and loss or injury of 1st degree relative in earthquake (p = 0.002) was higher in the PTSD group. The severity of psychiatric symptoms assessed with SCL-90-R was higher in the PTSD group than in the non-PTSD group (p < 0.001). Hippocampus and amygdala asymmetry was in favor of the left side in the PTSD group, while amygdala asymmetry was in favor of the right side in the non-PTSD group. After controlling for the effect of age in the PTSD group, a significant correlation was detected between total hippocampus volume and PCL-5 (r=-0.740, p < 0.001), SCL-90-R (r=-0.670, p < 0.001). According to the hierarchical binary logistic regression analysis, the sensitivity of age, gender, smoking status (block one) plus total hippocampus volume, amygdala asymmetry, loss or physical injury of 1st degree relative (block two) related to the determining the participants who was involved in PTSD and non-PTSD groups was 66.7%, and the specificity was 81.0% (Nagelkerke R<sup>2</sup> 0","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"653"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC PsychiatryPub Date : 2025-07-01DOI: 10.1186/s12888-025-07002-z
Yiyang Wang, Zhen Xu, Yinnan Zhang, Hui Li
{"title":"Identification of candidate genes associated with bipolar disorder by whole-exome sequencing of a Chinese multi-affected pedigree.","authors":"Yiyang Wang, Zhen Xu, Yinnan Zhang, Hui Li","doi":"10.1186/s12888-025-07002-z","DOIUrl":"https://doi.org/10.1186/s12888-025-07002-z","url":null,"abstract":"<p><strong>Background: </strong>Bipolar disorder (BD) is a severe mental disorder with high, approximately 70% heritability. Here, to identify novel risk genes of BD, we conducted whole-exome sequencing and pathway enrichment analyses across one multi-affected, southern Chinese Han pedigree.</p><p><strong>Methods: </strong>Whole-exome sequencing (WES) was performed on five patients with BD and three unaffected members in one multi-affected pedigree. The analyses focused on variants that (i) were shared by affected members but were not present in the unaffected members, and (ii) were rare and damaging. Bioinformatic analyses, including Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses, were used for functional annotation and pathway analysis.</p><p><strong>Results: </strong>We identified a rare and potentially damaging single nucleotide variations (SNVs) in NTN1, MYH10, and RILP that were shared by affected family members but were absent in unaffected members. Their functions were predicted to be associated with actin binding, substrate-dependent cell migration, actin cytoskeleton, and nucleotide excision repair.</p><p><strong>Conclusion: </strong>Our findings suggest that NTN1, MYH10, and RILP may represent novel candidate risk genes for BD, although further validation in larger cohorts is needed.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"612"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC PsychiatryPub Date : 2025-07-01DOI: 10.1186/s12888-025-07029-2
Cathrine Apelqvist, Tove Irmelid, Linda S Jonsson, Cecilia Fredlund
{"title":"Psychological processes and abilities for ceasing sex as self-injury- a qualitative study.","authors":"Cathrine Apelqvist, Tove Irmelid, Linda S Jonsson, Cecilia Fredlund","doi":"10.1186/s12888-025-07029-2","DOIUrl":"https://doi.org/10.1186/s12888-025-07029-2","url":null,"abstract":"<p><strong>Background: </strong>The term sex as self-injury (SASI) refers to sexual behaviors that are used as a means of self-injury, with motives such as emotional regulation comparable to other self-injurious behaviors, including burning or cutting the skin. The aim of this study was to explore which psychological processes and abilities that made it possible to cease SASI, to contribute to the knowledge that underpins psychological interventions and treatments.</p><p><strong>Method: </strong>The study was based on an open-ended questionnaire published on the websites of Swedish NGOs offering help and support to women and youths. In total 196 individuals with experience of SASI were included in the study. The age of the participants was 15-64 years (mean age 27.9 years), and most of the participants were women. Thematic analysis was used for the study, with the preunderstunding of cognitive behavioral therapy treatment and functional analysis.</p><p><strong>Results: </strong>Five abilities were seen as important for cessation of SASI; (1) Revised core beliefs about the self which were achieved through new experiences or cognitive restructuring. (2) Evolved emotional competence achieved through understanding or acceptance of emotions or new coping skills. (3) Increased relational competence via new relationship experiences or new communication skills. (4) Acquired meta-perspective through insight and knowledge of SASI. (5) Strengthened psychological empowerment through new relationships to the body and sexuality, transfer of responsibility or norm-critical perspective.</p><p><strong>Conclusions: </strong>Based on the results regarding psychological processes, acquired abilities and alternative behaviors, proposals for therapeutic interventions that may activate these processes were discussed.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"645"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Parenting styles and adolescent coping methods: a comparative study of non-suicidal self-injury and distinct groups.","authors":"Beini Wang, Lixian Chen, Changzhou Hu, Zhenyu Hu, Wenwu Zhang, Fang Cheng, Lingjiang Liu","doi":"10.1186/s12888-025-07042-5","DOIUrl":"https://doi.org/10.1186/s12888-025-07042-5","url":null,"abstract":"<p><strong>Background: </strong>The global incidence rate of Non-Suicidal Self-Injury (NSSI) is increasing year by year, especially in the adolescent population, where it is highly correlated with parental rearing patterns and adolescent coping styles. Exploring this correlation is crucial for understanding and intervening in NSSI behaviour.</p><p><strong>Objective: </strong>This study investigates the nuanced impact of parental parenting styles on coping strategies in adolescents, specifically contrasting these effects between NSSI and non-NSSI populations.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted on NSSI patients diagnosed at Ningbo Kangning Hospital in China from June 2020 to December 2021, as well as healthy adolescents from three junior high schools and three high schools in Ningbo City. The total sample consisted of 622 adolescents, aged 11 to 18, including 311 in the NSSI group (280 females, 31 males) and 311 in the non-NSSI group (269 females, 42 males). Data including family background, parenting styles, and adolescent coping strategies were collected. Descriptive statistics, chi-square test, independent samples t-test, correlation analysis, and stepwise regression analysis were used to analyse the data.</p><p><strong>Results: </strong>The study found significant correlations between family disharmony, parental education level, and NSSI behaviour. In non-NSSI adolescents, excessive maternal preference was negatively linked to problem-solving abilities, while in NSSI adolescents, negative parenting styles were associated with emotional-oriented coping strategies.</p><p><strong>Conclusion: </strong>The findings highlight critical differences in how parenting styles influence coping strategies in NSSI versus non-NSSI adolescents. This underscores the importance of positive parenting in preventing NSSI and suggests that psychological interventions should focus on enhancing emotional support and understanding from parents to foster healthier coping mechanisms in adolescents.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"611"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}