BMC Psychiatry最新文献

{"title":"Correction: Prevalence of depression and its correlates among undergraduate health science students in Mogadishu, Somalia: a cross-sectional study.","authors":"Bashiru Garba, Samiro Ali Mohamed, Maria Mowlid Mohamed, Hodo Aideed Asowe, Najib Isse Dirie, Yushau Umar, Jamal Hassan Mohamoud, Mohamed Hussein Adam, Jihaan Hassan, Fartun Abdullahi Hassan Orey, Abdullahi Abdirahman Omar, Ibrahim Abdullahi Mohamed, Mohamed Mustaf Ahmed, Samira Abdullahi Moalim","doi":"10.1186/s12888-025-06645-2","DOIUrl":"10.1186/s12888-025-06645-2","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"293"},"PeriodicalIF":3.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smoking impairs cognitive function through the mediating effect of periodontitis in older adults.","authors":"Xiaoqian Luan, Zhou Jin, Shenhang Xia, Jin Li, Yao An, Jiaqi Gao, Shengya Wang, Huwei Xia, Sipei Pan, Yao Zhang, Weihong Song, Yili Wu","doi":"10.1186/s12888-025-06699-2","DOIUrl":"10.1186/s12888-025-06699-2","url":null,"abstract":"<p><strong>Objectives: </strong>Evidence has shown that both smoking and periodontitis were linked to cognitive impairment. This study examines whether periodontitis mediates the effects of smoking status on cognitive function in older adults.</p><p><strong>Methods: </strong>Using data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014, the study included 1728 older participants who have data on smoking, serum cotinine, periodontal examination, and cognitive function. Mediation analysis was performed to test whether extent of periodontitis mediated associations between smoking status and cognitive function, adjusted for sociodemographic and basic health factors.</p><p><strong>Results: </strong>Compared to never-smokers, daily smokers exhibited significantly worse global cognitive function, with periodontitis mediating this effect (effect= -0.16; 95% CI= -0.29, -0.05). Similarly, periodontitis mediated the association between serum cotinine levels and cognitive function in the total sample (effect= -0.02; 95% CI= -0.03, -0.00).</p><p><strong>Conclusions: </strong>Periodontitis significantly mediates the impact of smoking on cognitive function. The findings highlight the potential roles of maintaining oral health and smoking cessation in mitigating cognitive decline.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"292"},"PeriodicalIF":3.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal trajectories of subjective cognitive complaints in patients with major depressive disorder and similar objective cognitive trajectories.","authors":"Xuequan Zhu, Xiongying Chen, Yuanzhen Wu, Lei Feng, Xu Chen","doi":"10.1186/s12888-025-06538-4","DOIUrl":"10.1186/s12888-025-06538-4","url":null,"abstract":"<p><strong>Background: </strong>We examined the factors influencing various subtypes of subjective cognitive change in patients who shared similar objective cognitive trajectories within 6 months.</p><p><strong>Method: </strong>We used data from an observational, prospective, cohort study, including 598 patients with major depressive disorder (MDD) in latent class mixed models based on the digit symbol substitution test performance. Participants were stratified into four distinct objective cognitive layers: \"low cognitive performance,\" \"lower-middle cognitive performance,\" \"upper-middle cognitive performance,\" and \"high cognitive performance.\" Within each of the four layers, the trajectories of subjective cognitive complaints were identified. Multinomial regression was employed, with cognitive complaint trajectories as the outcome, and depressive symptoms, clinical features, and other covariates as predictors.</p><p><strong>Results: </strong>The factors influencing the subjective trajectories varied among the different objective layers. Patients with comorbid anxiety disorders or functional syndromes had more prominent self-reported cognitive symptoms and a slower rate of improvement. Younger age and lower education level were also influential factors for delayed remission of subjective cognitive function. Disease severity and antidepressant type did not contribute to dedifferentiating subjective cognitive trajectory subtypes within different subjective cognitive trajectories.</p><p><strong>Conclusion: </strong>Despite similar objective cognitive trajectories, subjective perceptions of these cognitive changes are heterogeneous. These findings deepen our understanding of the multifaceted nature of cognitive change in individuals with MDD and underscore the importance of considering a range of factors when interpreting and treating cognitive impairment at an early stage.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"287"},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-driven development of a stratified CES-D screening system: optimizing depression assessment through adaptive item selection.","authors":"Ruo-Fei Xu, Zhen-Jing Liu, Shunan Ouyang, Qin Dong, Wen-Jing Yan, Dong-Wu Xu","doi":"10.1186/s12888-025-06693-8","DOIUrl":"10.1186/s12888-025-06693-8","url":null,"abstract":"<p><strong>Objective: </strong>To develop a stratified screening tool through machine learning approaches for the Center for Epidemiologic Studies Depression Scale (CES-D-20) while maintaining diagnostic accuracy, addressing the efficiency limitations in large-scale applications.</p><p><strong>Methods: </strong>Data were derived from the Chinese Psychological Health Guard Project (primary sample: n = 179,877; age 9-18) and China Labor-force Dynamics Survey (validation samples across age spans). We employed a two-stage machine learning approach: first applying Recursive Feature Elimination with multiple linear regression to identify core predictive items for total depression scores, followed by logistic regression for optimizing depression classification (CES-D ≥ 16). Model performance was systematically evaluated through discrimination (ROC analysis), calibration (Brier score), and clinical utility analyses (decision curve analysis), with additional validation using random forest and support vector machine algorithms across independent samples.</p><p><strong>Results: </strong>The resulting stratified screening system consists of an initial four-item rapid screening layer (encompassing emotional, cognitive, and interpersonal dimensions) for detecting probable depression (AUC = 0.982, sensitivity = 0.945, specificity = 0.926), followed by an enhanced assessment layer with five additional items. Together, these nine items enable accurate prediction of the full CES-D-20 total score (R² = 0.957). This stratified approach demonstrated robust generalizability across age groups (R² > 0.94, accuracy > 0.91) and time points. Calibration analyses and decision curve analyses confirmed optimal clinical utility, particularly in the critical risk threshold range (0.3-0.6).</p><p><strong>Conclusions: </strong>This study contributes to the refinement of CES-D by developing a machine learning-derived stratified screening version, offering an efficient and reliable approach that optimizes assessment burden while maintaining excellent psychometric properties. The stratified design makes it particularly valuable for large-scale mental health screening programs, enabling efficient risk stratification and targeted assessment allocation.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"286"},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schema therapy in partially sighted individuals with a focus on social isolation and self-esteem: an interventional study.","authors":"Amirhossein Abbasi, Jamileh Farokhzadian, Mahya Torkaman, Sakineh Miri","doi":"10.1186/s12888-025-06732-4","DOIUrl":"10.1186/s12888-025-06732-4","url":null,"abstract":"<p><strong>Background: </strong>Visual impairment can lead to low self-esteem and social isolation for partially sighted individuals. Schema therapy offers a systematic approach to identifying and modifying maladaptive schemas formed in the past. This therapy has proven effective in treating mental disorders and preventing their recurrence. This study aimed to investigate the effectiveness of schema therapy in addressing social isolation and enhancing self-esteem among partially sighted individuals.</p><p><strong>Methods: </strong>This interventional study involved 66 partially sighted individuals who referred to Tavangaran Institute in Shiraz, southwestern Iran. Participants were randomly assigned to two groups: an intervention group (n = 33) and a control group (n = 33). The intervention group received eight sessions of schema therapy over four weeks, with two sessions per week. Data were collected from both groups using the University of California at Los Angeles Loneliness Scale and the Rosenberg Self-Esteem Scale at three time points: before the intervention, immediately after the intervention, and one month post-intervention.</p><p><strong>Results: </strong>Mean social isolation scores in the intervention group decreased significantly from 65.03 ± 2.76 before the intervention to 35.93 ± 2.80 immediately after the intervention, and 38.36 ± 3.19 one month later (p < 0.001). Additionally, mean self-esteem scores increased significantly from 13.27 ± 1.27 to 22.30 ± 2.24 immediately after the intervention and 20.75 ± 2.43 one month after the intervention (p < 0.001). These post-intervention scores were significantly higher than that in the control group (p-value < 0.001).</p><p><strong>Conclusion: </strong>The results of this study demonstrated the effectiveness of schema therapy in improving self-esteem and reducing social isolation among partially sighted individuals. Healthcare providers, including psychologists and psychiatric nurses, are encouraged to consider using this intervention with other vulnerable groups, such as individuals with disabilities or physical impairments, who may experience similar challenges in self-esteem and social interaction.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"289"},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of an opioid use disorder medication implementation intervention on hospitalization and emergency department utilization in the Veterans Health Administration.","authors":"Madeline C Frost, Carol A Malte, Amy J Kennedy, Andrew J Saxon, Adam J Gordon, Hildi J Hagedorn, Emily C Williams, Ryan S Trim, Aline Lott, Anissa N Danner, Eric J Hawkins","doi":"10.1186/s12888-025-06722-6","DOIUrl":"10.1186/s12888-025-06722-6","url":null,"abstract":"<p><strong>Background: </strong>It is important to evaluate how medication for opioid use disorder (MOUD) implementation interventions impact downstream outcomes, however little is known about impact on hospitalization and emergency department (ED) utilization. Stepped Care for Opioid Use Disorder Train the Trainer (SCOUTT) is a national United States Veterans Health Administration (VHA) effort initially implemented at 18 facilities that increased MOUD receipt in primary care, mental health, and pain clinics. This evaluation assessed SCOUTT's impact on hospitalization and ED utilization.</p><p><strong>Methods: </strong>This evaluation used a controlled interrupted time series analysis. We extracted electronic health record data for patients with OUD and ≥ 1 visit in an intervention clinic (N = 35) or matched comparison clinic (N = 35) in the post-implementation year. We examined monthly measures of hospitalization and ED utilization in the pre-implementation (9/1/2017-8/31/2018) and post-implementation (9/1/2018-8/31/2019) years. Segmented regression models estimated pre-post immediate and trend changes in intervention relative to comparison clinics, adjusting for pre-implementation trends and patient characteristics. Sensitivity analyses were conducted among patients with ≥ 1 visit in both the pre-/post-implementation years, and post-hoc secondary analyses were conducted among patients with OUD and ≥ 1 other SUD vs. OUD only.</p><p><strong>Results: </strong>Patients with OUD in both intervention (N = 7,488) and comparison (N = 7,558) clinics had a mean age of 53 years, and the majority were male, White, and not married. During the pre-implementation period, hospitalization and ED utilization increased over time in both intervention and comparison clinics; during the post-implementation period, hospitalization and ED utilization decreased over time in intervention clinics and remained stable in comparison clinics. There was no significant difference in pre-post changes between intervention and comparison clinics for most analyses. In sensitivity analyses the pre-to-post decrease in monthly trend for ED visits was larger in intervention clinics and, in secondary analyses, the pre-to-post decrease in monthly trend for hospitalizations was larger in intervention clinics among patients with OUD and ≥ 1 other SUD.</p><p><strong>Conclusions: </strong>This evaluation did not find evidence that SCOUTT substantially impacted hospitalization or ED utilization relative to comparison clinics, though there may have been positive impacts for patients with longer engagement in SCOUTT clinics and patients with OUD and ≥ 1 other SUD.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"288"},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between time perspective and depressive symptoms in young people working in high-altitude environments.","authors":"Nan Mu, Lili Zhang, Mengyin Zhu, Zhengzhi Feng, Yan-Jiang Wang","doi":"10.1186/s12888-025-06710-w","DOIUrl":"10.1186/s12888-025-06710-w","url":null,"abstract":"<p><strong>Background: </strong>Depression rates are significantly higher in high-altitude regions, making it important to understand its underlying mechanisms. Time perspective, which refers to how individuals perceive their past, present, and future, is closely linked to depression in low-altitude areas. However, its relationship with depression in high-altitude regions remains unclear.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted with 4942 young male workers from high-altitude regions. The association between time perspectives and depressive symptoms were examined by univariate and multivariate analyses. Network analysis was employed to identify central symptoms and their interactions, and to compare the differences between individuals with and without depression.</p><p><strong>Results: </strong>The study identified that elevated past negative (PN), reduced past positive (PP), increased present fatalistic (PF) and present hedonistic (PH) orientations, and lower future (F) were significant risk factors for depressive symptoms in plateau populations. In the network structure of the depression group, PN, PF, PH, SDS18 \"emptiness\", and SDS13 \"psychomotor agitation\" were key elements influencing depressive symptoms and the strongest edge was F-PP. Significant differences were detected between the depressive and non-depressive groups, with the depressive group demonstrating significantly greater global strength invariance and a more robust network invariance.</p><p><strong>Conclusions: </strong>Abnormal time perspectives, especially PN, PF and PH were strongly associated with depression in high-altitude environments, and the strong connection between F-PP provides a potential intervention target. Future research should further explore the causal relationship.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"278"},"PeriodicalIF":3.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Pharmacological management of acute agitation in psychiatric patients: an umbrella review\".","authors":"Erasmo Saucedo Uribe, Cynthia Alejandra Bravo Rodríguez, Miguel Emanuel Navarrete Juárez, Samantha Medrano Juárez, Rodrigo Huereca Lucio, Kevin Eduardo Rojas Guzmán, Luis Carlos Lozano Carrillo","doi":"10.1186/s12888-024-06426-3","DOIUrl":"10.1186/s12888-024-06426-3","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The main characteristics present in patients with psychomotor agitation include restlessness, excessive motor activity, irritability, and heightened responsiveness to internal and external stimuli. This umbrella review evaluates the efficacy and safety of pharmacological interventions for patients with psychiatric disorders presenting psychomotor agitation, aged 18 years or older. A comprehensive literature search was conducted to identify umbrella reviews that met our study's inclusion criteria. However, no reviews were found that specifically investigated the efficacy and safety of pharmacological interventions for agitated psychiatric patients presenting with both behavioral and psychological symptoms, such as emotional lability, decreased attention span, and cognitive and behavioral alterations. The primary objective is to assess the effectiveness of pharmacological interventions in controlling patients within a short time frame, measured in hours rather than days. The focus was placed on studies addressing treatment in emergency settings, whether in general hospitals or psychiatric facilities, with an emphasis on managing acute psychomotor agitation rather than long-term maintenance treatment.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Method: &lt;/strong&gt;A comprehensive literature search for meta-analyses and systematic reviews assessing the efficacy and safety of pharmacological treatment for psychomotor agitation in psychiatric inpatients and emergency department patients was conducted across various databases such as PubMed, Scopus, EMBASE, Web of Science and COCHRANE Central database. Included reviews comprised those that incorporated randomized controlled trials (RCTs) or non-randomized controlled trials (NRCTs) comparing the efficacy and safety of pharmacological interventions for agitated psychiatric patients (with both psychological and behavioral symptoms).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Loxapine (10 mg) demonstrated superior efficacy over 5 mg in reducing agitation within 120 min, with inhaled formulations providing rapid relief in patients with acute psychosis. Aripiprazole was effective and caused less sedation compared to Olanzapine, although Haloperidol required fewer additional doses but was less effective at 60 min. Ziprasidone, administered intramuscularly, offered a faster onset and was better tolerated than Haloperidol. Lorazepam proved effective with fewer side effects than antipsychotics and showed enhanced efficacy when combined with them. Midazolam provided rapid sedation but posed risks of severe side effects, especially in older adults. Droperidol was as effective as Olanzapine but provided faster sedation. Combination therapy, such as Haloperidol with Promethazine, effectively reduced aggression with a lower incidence of adverse effects.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This umbrella review offers a comprehensive overview of the pharmacological management of psychomotor agitation in patients with psychiatric dis","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"273"},"PeriodicalIF":3.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality in national psychiatric hospitals in Sudan: a fifteen-year review of hospital deaths.","authors":"Abdelgadir Hussein M Osman, Mohga Mohamed, Ibtihal A Osman, Khalid A Abdalhai, Lubaba A Elawad","doi":"10.1186/s12888-025-06726-2","DOIUrl":"10.1186/s12888-025-06726-2","url":null,"abstract":"<p><strong>Background: </strong>Mortality rates in psychiatric hospitals reflect the intricate challenges faced within mental healthcare systems globally. Mortality auditing of in-patient psychiatric hospitals for a period extending 14 years is rare in low-income countries. We are reporting a 15-year mortality review of Sudan's National Psychiatric Hospitals. It is intended to enhance the standard of care in low-resource settings.</p><p><strong>Methods: </strong>A retrospective audit was conducted in primary psychiatric hospitals across Sudan's capital city over a 15-year period. Missing or incomplete data were addressed by cross-referencing available hospital records, consulting medical staff for clarifications when possible, and excluding cases where critical information was unavailable. Data on deceased patients were collected from hospital records, encompassing demographic details, medical histories, psychiatric diagnoses, pharmacological interventions, and causes of death.</p><p><strong>Results: </strong>The study identified 108 deaths out of 28,085 admissions, yielding a mortality rate of 0.38 per cent. The majority of deceased patients were male 71 (65.7%), aged below 40 years 65 (60.2%), and experienced shorter durations of hospital stay before death, with significant mortality occurring within the first week of admission. Common causes of death included infections 30 (27.7%), circulatory failure 27 (24.3%), and no clear cause 17 (15.7%). The main diagnoses of deceased patients were, major mood disorders and mania 42 (38.9%), schizophrenia /schizophrenia-like psychosis 27 (25.0%) and organic psychosis and drug-induced psychosis 16 (14.8%). Haloperidol emerged as the most frequently prescribed medication before death.</p><p><strong>Conclusion: </strong>Infection and circulatory failure are the leading causes of mortality in Sudanese mental hospitals, necessitating a thorough examination to find remedies for these avoidable problems. Additionally, enhanced monitoring and early intervention, particularly in the critical initial phase of hospitalization, are essential for mitigating mortality risks associated with psychotropic medications.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"279"},"PeriodicalIF":3.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient and public involvement in basic and clinical psychiatric research: a scoping review of reviews.","authors":"Anne Werner, Julia Lauberger, Anke Steckelberg, Gabriele Meyer","doi":"10.1186/s12888-025-06608-7","DOIUrl":"10.1186/s12888-025-06608-7","url":null,"abstract":"<p><strong>Background: </strong>Patient and public involvement (PPI) in health research has become established as an essential component of international health research. Particularly, patients and stakeholders' commitment to psychiatric research faces various challenges. This scoping review aimed to examine the existing literature to identify the aims, methods, barriers, and facilitators of PPI in clinical and basic psychiatric research.</p><p><strong>Methods: </strong>This scoping review's methods were guided by the framework proposed by Arksey and O'Malley. The literature search was conducted between October and November 2023 on six databases (MEDLINE, Web of Science, EMBASE, PsycInfo, PubPsych, and the Cochrane Library). We included reviews that summarized the results of primary studies describing methods for PPI in psychiatric scientific research, regardless of their subjects' underlying psychiatric conditions and the primary research context (clinical or preclinical). The inclusion criteria included a description of the methods, components, and characteristics of participation in psychiatric research. We included reviews published between 2008 and 2023 regardless of participants' language, country, or age.</p><p><strong>Findings: </strong>Twenty reviews comprising 429 studies were included. They revealed that PPI was used to pursue various objectives (e.g., prioritizing research questions). Common methods included focus groups, advisory boards, workshops and interviews. Only one review reported financial compensation for those involved. PPI ranged from tokenism to involvement in data analysis and the dissemination of findings. Facilitators and barriers were identified in relationship and communication factors, organizational and practical factors, and in (co-) researchers training. The most frequently mentioned facilitators of successful PPI were trust and strong relationships. The most frequently mentioned barrier was the power imbalance between the participants and researchers. We identified positive and potential negative effects of PPI.</p><p><strong>Conclusion: </strong>Golden rules for practice (clinical and basic research) derived from the results are as follows: (I) Foster a culture of collaboration and mutual respect between researchers and PPI participants. (II) Provide adequate resources and support for PPI activities, including funding and training programs. (III) Develop clear guidelines and standards for PPI to ensure consistency and quality. (IV) Develop a willingness to integrate PPI into all phases of research, from planning to the dissemination of results. SCOPING REVIEW REGISTRATION: https://doi.org/10.17605/OSF.IO/7YS5C .</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"283"},"PeriodicalIF":3.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}