BMC Psychiatry最新文献

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Post-traumatic stress disorder in earthquake survivors living in temporary shelter areas in Hatay central districts: a cross-sectional study. 哈塔伊中部地区临时避难所地震幸存者的创伤后应激障碍:一项横断面研究。
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2025-05-07 DOI: 10.1186/s12888-025-06919-9
Ertan Yilmaz, Mehmet Erdem
{"title":"Post-traumatic stress disorder in earthquake survivors living in temporary shelter areas in Hatay central districts: a cross-sectional study.","authors":"Ertan Yilmaz, Mehmet Erdem","doi":"10.1186/s12888-025-06919-9","DOIUrl":"https://doi.org/10.1186/s12888-025-06919-9","url":null,"abstract":"<p><strong>Background: </strong>The 2023 Kahramanmaraş earthquakes resulted in extensive destruction, significant loss of life, and widespread displacement, with Hatay province being the most severely affected region. Earthquake survivors residing in temporary shelters face an elevated risk of long-term psychological consequences, particularly post-traumatic stress disorder (PTSD) and depression. This study aims to assess the prevalence of PTSD and depression among earthquake survivors in temporary shelter areas within the central districts of Hatay and to identify associated risk factors contributing to PTSD.</p><p><strong>Methods: </strong>This cross-sectional, population-based study was conducted among 400 adult earthquake survivors following the 2023 Kahramanmaraş earthquakes. Participants were selected using a multistage cluster sampling method. Data on participants' sociodemographic characteristics, earthquake experiences, and psychiatric history were collected through self-report questionnaires. PTSD was assessed using the PTSD Checklist for DSM-5 (PCL-5), while depression was evaluated using the Beck Depression Inventory.</p><p><strong>Results: </strong>PTSD was identified in 29.0% of participants, while depression was observed in 38.8%. Key risk factors for PTSD included unemployment (OR = 2.590, p = 0.004), the loss of a family member (OR = 2.351, p = 0.017), a pre-existing psychiatric diagnosis prior to the earthquakes (OR = 2.245, p = 0.007), alcohol use (OR = 2.310, p = 0.019), smoking (OR = 1.663, p = 0.044), and experiencing a high level of fear during the earthquakes (OR = 2.151, p = 0.002).</p><p><strong>Conclusions: </strong>These findings highlight the critical need for large-scale psychosocial support and intervention programs in the post-disaster period. Identifying risk factors for PTSD may aid in the development of targeted treatment strategies and preventive interventions for affected individuals.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"461"},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of seasonal variations for the seasonal pattern assessment in mood disorder patients and healthy controls. 情绪障碍患者和健康对照季节性模式评估的季节性变化评估。
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2025-05-07 DOI: 10.1186/s12888-025-06916-y
Chiao-Erh Chang, Hsi-Chung Chen, I-Ming Chen, Cheng-Dien Hsu, Chih-Ming Liu, Chun-Hsin Chen, Tsung-Yang Wang, Wen-Yin Chen, Shiau-Shian Huang, Yen-Chih Chen, Po-Hsiu Kuo
{"title":"Evaluation of seasonal variations for the seasonal pattern assessment in mood disorder patients and healthy controls.","authors":"Chiao-Erh Chang, Hsi-Chung Chen, I-Ming Chen, Cheng-Dien Hsu, Chih-Ming Liu, Chun-Hsin Chen, Tsung-Yang Wang, Wen-Yin Chen, Shiau-Shian Huang, Yen-Chih Chen, Po-Hsiu Kuo","doi":"10.1186/s12888-025-06916-y","DOIUrl":"https://doi.org/10.1186/s12888-025-06916-y","url":null,"abstract":"<p><strong>Background: </strong>Seasonal disturbances were common in mood disorders patients. The global seasonality score (GSS), derived from the Seasonal Pattern Assessment Questionnaire (SPAQ), was widely used to assess seasonality and related symptoms. This study aimed to establish the structure of the Chinese version of SPAQ. We examined the stability of seasonal pattern assessment across four seasons when administering SPAQ. The prevalence of seasonal affective disorder was estimated using SPAQ criteria.</p><p><strong>Methods: </strong>We recruited 596 mood disorder patients and 138 healthy controls (HC), with 121 patients and 37 HC followed up over four seasons. An exploratory factor analysis examined the GSS factor structure. We evaluated correlations between GSS symptom dimensions and \"the degree of problems due to seasonal changes\" and used intraclass correlation coefficient reliability (ICCR) to assess the consistency of symptom dimensions across seasons.</p><p><strong>Results: </strong>Approximately a quarter of mood disorder patients met the criteria for seasonal affective disorder. The Chinese SPAQ revealed a two-factor structure: psychological and food-related symptoms among patients. The GSS showed a significant correlation (r = 0.64) with the degree of problems due to seasonal changes in mood disorder patients, while energy level and sleep significantly correlated with GSS (r > 0.75) in HC. Reporting reliability (ICCR > 0.4) was acceptable for GSS and mood/energy levels in patients across seasons.</p><p><strong>Conclusions: </strong>Seasonal variations were observed in reporting the symptom dimensions of the seasonal pattern assessment, while the GSS remained relatively stable in both mood disorder patients and HC. SPAQ is a useful tool for measuring seasonality, irrespective of the season of administration.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"458"},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Course of mental distress among psychotherapists throughout two years of the COVID- 19 pandemic: individual and inter-relational resources make a difference-cross-sectional and longitudinal results of the VOICE study. 在COVID- 19大流行的两年中,心理治疗师的精神痛苦过程:个体和相互关系的资源会产生差异——VOICE研究的横断面和纵向结果。
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2025-05-06 DOI: 10.1186/s12888-025-06867-4
Sabine Mogwitz, Gloria-Beatrice Wintermann, Christian Albus, Andreas M Baranowski, Petra Beschoner, Yesim Erim, Franziska Geiser, Lucia Jerg-Bretzke, Eva Morawa, Susann Steudte-Schmiedgen, Kerstin Weidner
{"title":"Course of mental distress among psychotherapists throughout two years of the COVID- 19 pandemic: individual and inter-relational resources make a difference-cross-sectional and longitudinal results of the VOICE study.","authors":"Sabine Mogwitz, Gloria-Beatrice Wintermann, Christian Albus, Andreas M Baranowski, Petra Beschoner, Yesim Erim, Franziska Geiser, Lucia Jerg-Bretzke, Eva Morawa, Susann Steudte-Schmiedgen, Kerstin Weidner","doi":"10.1186/s12888-025-06867-4","DOIUrl":"https://doi.org/10.1186/s12888-025-06867-4","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic has posed challenges to healthcare systems worldwide. For healthcare workers (HCW), an increased prevalence of mental distress and the impact of various resources have been identified. Psychotherapists specialise in helping people cope with stressful life events. At the same time, they are susceptible to mental distress, resulting from their work. Data on symptoms of depression and the role of resources during the COVID-19 pandemic are scarce for psychotherapists. Therefore, the present study aimed to evaluate the course of self-reported depression of psychotherapists throughout the COVID-19 pandemic. Additionally, the impact of resources on depression was evaluated.</p><p><strong>Methods: </strong>We investigated symptoms of depression using the Patient Health Questionnaire-2 (PHQ-2) at four time points (T1-T4) during the COVID-19 pandemic in Germany. The PHQ-2 scores and resources such as sense of coherence (SOC), general optimism and social support (ESSI-D) of the psychotherapists (N = 1733) were compared with those of a comparison sample of HCW (N = 8470). The impact of resources on PHQ-2 scores was examined using cross-sectional linear modelling and longitudinal linear mixed modelling with interactions and lagged predictors.</p><p><strong>Results: </strong>At T1-T4, psychotherapists showed lower mean PHQ-2 scores than the comparison sample (p < 0.001). Among psychotherapists, the PHQ-2 scores increased (T1-T2, and T1-T4, p < 0.050). Cross-sectionally, higher SOC was associated with lower PHQ-2 scores (p < 0.001), with the protective influence weakening over time (p = 0.033). Longitudinal analyses confirmed a protective effect of sense of coherence (stable over time) and general optimism (declining over time) on PHQ-2 scores. An exploratory lagged-predictor analysis suggested that higher social support was associated with lower PHQ-2 scores, whereas higher general optimism was linked to increasing PHQ-2 scores.</p><p><strong>Conclusions: </strong>This study revealed lower levels of depression among psychotherapists compared with the comparison sample throughout the pandemic. Concurrently, the resource levels were mostly comparable and stable, with a protective impact of the sense of coherence (stable) and optimism (decreasing) and an association of high social support with low depression throughout the pandemic. Strengthening the sense of coherence and social support should be the focus of professional and policy attention to improve the ability of psychotherapists to cope with future crises.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"456"},"PeriodicalIF":3.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A simulation-based network analysis of intervention targets for comorbid symptoms of depression and anxiety in Chinese healthcare workers in the post-dynamic zero-COVID policy era. 后动态零冠政策时代中国医护人员抑郁和焦虑共病症状干预目标的模拟网络分析
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2025-05-06 DOI: 10.1186/s12888-025-06931-z
Chao Zhang, Ruyong Li, Wei Zhang, Yanqiang Tao, Xiangping Liu, Yichao Lv
{"title":"A simulation-based network analysis of intervention targets for comorbid symptoms of depression and anxiety in Chinese healthcare workers in the post-dynamic zero-COVID policy era.","authors":"Chao Zhang, Ruyong Li, Wei Zhang, Yanqiang Tao, Xiangping Liu, Yichao Lv","doi":"10.1186/s12888-025-06931-z","DOIUrl":"https://doi.org/10.1186/s12888-025-06931-z","url":null,"abstract":"<p><strong>Background: </strong>After the official end of the dynamic zero-COVID policy in China, healthcare workers continued to heavy workloads and psychological stress. In this new phase, concerns related to work and family, rather than infection, may have become new sources of psychological issues such as depression and anxiety among healthcare workers, leading to new patterns of comorbidity. However, few studies have addressed these issues. To fill this gap, this study used network analysis to examine new features and mechanisms of comorbidity between depression and anxiety symptoms, and simulated symptom-specific interventions to identify effective targets for intervention.</p><p><strong>Methods: </strong>A total of 708 Chinese healthcare workers (71.2% females; Age: M = 37.55, SD = 9.37) were recruited and completed the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7). This study first calculated the incidence rates of anxiety, depression, and their comorbidity, and then constructed the comorbid Ising network. Central and bridge symptoms were identified with expected influence (EI) and bridge EI, respectively. The NodeIdentifyR algorithm (NIRA) was then used to simulate interventions within the network, examining the effects of alleviating or aggravating specific symptoms on the network's severity.</p><p><strong>Results: </strong>48.2% of Chinese healthcare workers reported experiencing depression (19.8%), anxiety (11.7%), or both (16.2%). In the anxiety-depression network, \"guilt\" and \"appetite changes\" were identified as the central symptoms, and \"guilt\" and \"excessive worry\" were identified as the bridge symptoms. Simulated interventions suggested that alleviating \"Anhedonia\" can the most reduce the overall severity of the network, while aggravating \"guilt\" can the most increase the overall severity. These two symptoms were considered the key target for treatment and prevention, respectively.</p><p><strong>Conclusions: </strong>Chinese healthcare workers still face high risk of depression, anxiety, and comorbidity in the post-dynamic zero-COVID policy era. Our findings highlight the key roles of guilt, appetite changes, and excessive worry in the network of depression and anxiety symptoms. Future research should apply the results of the simulated interventions, develop intervention strategies targeting anhedonia, and focus on preventing guilt to improve the healthcare workers' mental health.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"457"},"PeriodicalIF":3.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of the relationship between cognitive flexibility, theory of mind and creative thinking in patients with bipolar disorder. 双相情感障碍患者认知灵活性、心理理论与创造性思维关系的研究。
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2025-05-06 DOI: 10.1186/s12888-025-06908-y
Sefanur Köse, Çiçek Hocaoğlu
{"title":"Investigation of the relationship between cognitive flexibility, theory of mind and creative thinking in patients with bipolar disorder.","authors":"Sefanur Köse, Çiçek Hocaoğlu","doi":"10.1186/s12888-025-06908-y","DOIUrl":"https://doi.org/10.1186/s12888-025-06908-y","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to analyse the differences in creative thinking dispositions between patients with bipolar disorder (BD) and healthy controls (HCs) and to examine the potential role of cognitive flexibility (CF) and theory of mind (ToM) as mediators of this relationship.</p><p><strong>Methods: </strong>Fifty patients diagnosed with BD in remission and fifty HCs participated in the study. The participants completed the Wisconsin Card Sorting Test (WCST), the Reading the Mind in the Eyes Test (RMET), the Dokuz Eylul Theory of Mind Index (DEToMI) and the Marmara Creative Thinking Dispositions Scale (MCTDS).</p><p><strong>Results: </strong>There was no significant difference between the groups in terms of creative thinking dispositions, t(98)=-0.99, p =.323. However, patients performed worse in several areas, such as the number of perseverative errors (PEs) t(98) = 4.84, p <.001, number of completed categories (z=-4.38, p <.001), DEToMI total score t(98)=-3.51, p <.001, and RMET score t(98)=-2.77, p <.007, than HCs. In the patient group, correlations were found between innovation search and irony scores (r (48) = 0.44, p =.001) and between innovation search and the DEToMI total score (r [(48) = 0.44, p =.002). In the HC group, associations were found between PEs and innovation search, r (48)=-0.33, p =.019; PEs and inquisitive, r (48)=-0.29, p =.044; SOFB and inquisitive, r (48) = - 0.30, p =.034; doubt and irony, r (48) = 0.29, p =.043; and the RMET score and courage, r (48)=-0.31, p =.027. In the HC group, 44% of the MCTDS score was explained by the model variables at a statistically significant level.</p><p><strong>Limitations: </strong>Not all factors affecting creative thinking dispositions and cognitive functions were examined.</p><p><strong>Conclusions: </strong>The relationship between creativity and BD varies depending on the research approach; however, consistent with the current literature, our study found no significant differences in creative thinking dispositions between the groups. While CF and ToM predicted creative thinking in healthy individuals, they do not predict these dispositions in BD patients. Therefore, focusing on other cognitive factors related to creativity in individuals with BD may help clarify this issue. Our study contributes to the limited literature by investigating the effects of CF and ToM on creative thinking dispositions in BD patients.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"455"},"PeriodicalIF":3.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The genetic overlap and causal relationship between attention deficit hyperactivity disorder and obstructive sleep apnea: a large-scale genomewide cross-trait analysis. 注意缺陷多动障碍和阻塞性睡眠呼吸暂停之间的遗传重叠和因果关系:一项大规模全基因组交叉性状分析。
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2025-05-06 DOI: 10.1186/s12888-025-06899-w
Yao Tong, Yan-Jing Chen, Guang-Bin Cui
{"title":"The genetic overlap and causal relationship between attention deficit hyperactivity disorder and obstructive sleep apnea: a large-scale genomewide cross-trait analysis.","authors":"Yao Tong, Yan-Jing Chen, Guang-Bin Cui","doi":"10.1186/s12888-025-06899-w","DOIUrl":"https://doi.org/10.1186/s12888-025-06899-w","url":null,"abstract":"<p><strong>Background: </strong>Attention deficit hyperactivity disorder (ADHD) and Obstructive sleep apnea (OSA) are highly clinically co-occurring, but the mechanisms behind this remain unclear, so this article analyzes the reasons for the co-morbidities from a genetic perspective.</p><p><strong>Methods: </strong>We examined the genetic architecture of ADHD and OSA based on the large genome-wide association studies (GWAS). The global genetic relationship between OSA and ADHD was explored. Cross-trait analysis from single nucleotide polymorphism (SNP) and gene level was performed subsequently to detect the crucial genomic regions. Finally, we revealed the anatomical change on which genetic overlap relies and further explored whether genetic factors exert a causal effect.</p><p><strong>Results: </strong>After using both linkage disequilibrium score regression (LDSC) and High-definition likelihood inference (HDL) methods, we identified a significant genetic correlation between OSA and ADHD (PLDSC = 2.45E-28, PHDL = 1.09E-25), demonstrating a consistent direction. Furthermore, through the application of various cross-trait methods, we pinpointed 5 loci and 57 genes involved in regulating the co-occurrence of these disorders. These genetic regions were thought to be associated with the prefrontal lobes (P = 3.07E-06) and the nucleus accumbens basal ganglia (P = 2.85E-06). Lastly, utilizing Mendelian randomization (MR), we established a link indicating that individuals with ADHD were at an elevated risk of developing OSA (PIVM = 0.02, OR (95%CI):1.09 (1.01-1.17)).</p><p><strong>Conclusions: </strong>This study reveals a strong genetic correlation between ADHD and OSA. It offers insights for future drug target development and sleep management in ADHD.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"454"},"PeriodicalIF":3.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of inhibition of reactivated alcohol-associated memories with propranolol on alcohol craving. 心得安抑制酒精相关记忆重新激活对酒精渴望的影响。
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2025-05-06 DOI: 10.1186/s12888-025-06904-2
Shuai Yu, Peng-Jiao Xu, Le Shi, Xiao-Yang Zhang, Chuan-Sheng Wang, Fang Wu, Xiao Li, Ping Cui, Rui-Ling Zhang, Lin Lu, Ya-Hui Xu
{"title":"Effect of inhibition of reactivated alcohol-associated memories with propranolol on alcohol craving.","authors":"Shuai Yu, Peng-Jiao Xu, Le Shi, Xiao-Yang Zhang, Chuan-Sheng Wang, Fang Wu, Xiao Li, Ping Cui, Rui-Ling Zhang, Lin Lu, Ya-Hui Xu","doi":"10.1186/s12888-025-06904-2","DOIUrl":"https://doi.org/10.1186/s12888-025-06904-2","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Alcohol craving and relapse occur after the reactivation of alcohol reward memory. Previous studies suggest that drug-associated memory undergoes reconsolidation once retrieved by drug-associated stimuli. This study hypothesized that propranolol administration during memory reconsolidation induced by conditioned stimulus (CS) would significantly attenuate alcohol craving.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 40 patients with alcohol dependence who met the diagnostic criteria for alcohol dependence in DSMV were enrolled. The patients were randomized located into the memory retrievalpropranolol group (n = 20) and the memory retrievalplacebo group (n = 20) using the random number table. The memory retrievalpropranolol group used propranolol combined with a memory retrieval reconsolidation procedure, while the memory retrievalplacebo group used a placebo combined with a memory retrieval reconsolidation procedure. The Visual Analog Scale (VAS) was used to evaluate the degree of alcohol craving induced by images at stages of baseline measures, relevance learning, and memory test. The systolic blood pressure, diastolic blood pressure, and heartrate were applied to evaluate cue responsiveness. Repeated measures analysis of variance was used to compare the craving degree and independent samples t-tests were used for comparing demographic characteristics, scale scores between alcohol-dependent patient groups, and pre-post differences in heart rate, systolic blood pressure, and diastolic blood pressure at each experimental phase.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Relevance learning stage: Compared with before learning, the levels of systolic blood pressure, diastolic blood pressure, and heart rate of the two groups increased in varying degrees after learning conditional stimulationrelevance learning CS+(all P &lt; 0.05). Compared with pre-learning, both groups showed increased VAS scores during the Retrieval phase with statistically significant differences (F = 47.294、25.015, all P &lt; 0.001). The memory test stage, after re-exposure to learned CS+, both groups showed varying degrees of increase in heart rate, systolic blood pressure, and diastolic blood pressure, with all differences reaching statistical significance (all P &lt; 0.05). During the test phase, statistically significant between-group differences were found in heart rate difference, systolic blood pressure difference and diastolic blood pressure difference between the two groups (all P &lt; 0.05). the retrieval-propranolol group demonstrated decreased VAS scores with statistical significance (F = 56.017, P &lt; 0.001), while the retrieval-placebo group showed no statistically significant alterations in VAS scores (F = 0.183, P &gt; 0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Our study demonstrated that propranolol administration after CS-induced retrieval could disrupt alcohol-associated memory reconsolidation and reduce alcohol craving. The finding provided a potential trans","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"453"},"PeriodicalIF":3.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systemic inflammation as a mediator in the link between obesity and depression: Evidence from a nationwide cohort study. 全身性炎症在肥胖和抑郁之间起中介作用:来自全国队列研究的证据。
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2025-05-05 DOI: 10.1186/s12888-025-06892-3
Xiaoqing Wang, Xinyue Liang, Ming Jiang, Ling Wei, Xiangpeng Shi, Fang Fang, Jing Cang
{"title":"Systemic inflammation as a mediator in the link between obesity and depression: Evidence from a nationwide cohort study.","authors":"Xiaoqing Wang, Xinyue Liang, Ming Jiang, Ling Wei, Xiangpeng Shi, Fang Fang, Jing Cang","doi":"10.1186/s12888-025-06892-3","DOIUrl":"https://doi.org/10.1186/s12888-025-06892-3","url":null,"abstract":"<p><strong>Background: </strong>Obesity and depression are major public health issues with a complex, bidirectional relationship potentially involving systemic inflammation.</p><p><strong>Methods: </strong>Using a diverse sample from the National Health and Nutrition Examination Survey (NHANES) (n = 11,324; weighted population = 456,457,366), we examined the associations between obesity, systemic inflammation, and depression. Obesity was classified by Body Mass Index (BMI), depressive symptoms were assessed with the Patient Health Questionnaire-9 (PHQ-9), and systemic inflammation was measured using markers like Neutrophil-to-Lymphocyte Ratio (NLR), Systemic Inflammation Response Index (SIRI), and Systemic Immune-Inflammation Index (SII). Weighted logistic regression models were used to assess relationships between obesity, inflammation, and depression. Linear regression evaluated BMI's association with inflammation markers, and Restricted Cubic Spline (RCS) analysis explored their interrelationships. Subgroup analyses and interaction tests were conducted, and mediation analysis examined the role of inflammation markers in mediating the obesity-depression association.</p><p><strong>Results: </strong>Class III obesity was associated with higher inflammatory marker levels and increased depression risk. Mediation analysis showed NLR, SIRI, and SII mediated 5.2%, 5.9%, and 6.1% of the obesity-depression relationship.</p><p><strong>Conclusions: </strong>Systemic inflammation partially mediates the relationship between obesity and depression.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"449"},"PeriodicalIF":3.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Measuring the prevalence, warning signs, and preventive measures of secondary traumatic stress among critical care nurses. 重症护理护士继发性创伤应激的患病率、警示标志及预防措施的测量。
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2025-05-05 DOI: 10.1186/s12888-025-06840-1
Marwa Al Barmawi, Batool El Shahrouri, Lourance Al Hadid, Majdi M Alzoubi, Khalid Al-Mugheed, Amany Anwar Saeed Alabdullah, Sally Mohammed Farghaly Abdelaliem
{"title":"Measuring the prevalence, warning signs, and preventive measures of secondary traumatic stress among critical care nurses.","authors":"Marwa Al Barmawi, Batool El Shahrouri, Lourance Al Hadid, Majdi M Alzoubi, Khalid Al-Mugheed, Amany Anwar Saeed Alabdullah, Sally Mohammed Farghaly Abdelaliem","doi":"10.1186/s12888-025-06840-1","DOIUrl":"https://doi.org/10.1186/s12888-025-06840-1","url":null,"abstract":"<p><p>Nurses are the front-liners for patients who need urgent care; therefore, they are exposed to several stressors. Indirect exposure to others' trauma is called secondary traumatic stress. This study examined the prevalence, warning signs, and preventive measures of secondary traumatic stress among critical care nurses in Jordan. A descriptive cross-sectional design was used. Data were collected through a questionnaire, both paper and electronic, from 317 nurses working in nine hospitals. Nurses in this study had moderate levels of secondary traumatic stress with a mean of 40.9 (SD = 11.29), and around half of them met the diagnostic criteria. Arousal was the most reported symptom followed by avoidance and lastly intrusion. The majority of nurses had a mild to moderate risk of developing secondary traumatic stress. Multiple traumatizing events had a positive relationship with STS prevalence. Nurses viewed the preventive measures as moderately to greatly effective. Efforts must be directed toward preventing, diagnosing, and treating secondary traumatic stress among critical care nurses.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"450"},"PeriodicalIF":3.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between sedentary behavior and dementia: a systematic review and meta-analysis of cohort studies. 久坐行为与痴呆之间的关系:队列研究的系统回顾和荟萃分析。
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2025-05-05 DOI: 10.1186/s12888-025-06887-0
Jinyan Luo, Yiping Huang, Gangqiang Gao, Ching-Wen Chien, Tao-Hsin Tung
{"title":"Association between sedentary behavior and dementia: a systematic review and meta-analysis of cohort studies.","authors":"Jinyan Luo, Yiping Huang, Gangqiang Gao, Ching-Wen Chien, Tao-Hsin Tung","doi":"10.1186/s12888-025-06887-0","DOIUrl":"https://doi.org/10.1186/s12888-025-06887-0","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the association between sedentary behavior (SB) and dementia among the general adult population.</p><p><strong>Methods: </strong>We queried PubMed, Web of Science, Embase, and Cochrane Library from their inception to November 3, 2024. Two authors independently extracted the data from included studies, including hazard ratios (HRs) and their 95% confidence intervals (CIs), to assess the risk of dementia among individuals with SB. The quality of included studies was assessed using the Newcastle-Ottawa Scale. We used a random effects model if I<sup>2</sup> > 50% and p < 0.10; otherwise, a fixed-effect model was used. In addition, we assessed publication bias by funnel plot, and performed leave-one-out sensitivity analysis.</p><p><strong>Results: </strong>We included ten cohort studies, nine of which were of high quality. Our analysis demonstrated an increased risk of dementia among individuals with SB (pooled HRs, 1.17; 95% CIs, 1.06-1.29). Individuals with high sedentary time (ST), defined by TV viewing, demonstrated a 31% increased risk of dementia compared to those with low ST (pooled HRs, 1.31; 95% CIs, 1.25-1.37). No significantly increased risk for dementia was observed among individuals with high computer usage time (pooled HRs, 0.89; 95% CIs, 0.73-1.09). However, when SB was defined by other methods, individuals with high ST demonstrated a 33% increased risk of dementia compared to those with low ST (pooled HRs, 1.33; 95% CIs, 1.25-1.42).</p><p><strong>Conclusion: </strong>SB increases the risk of dementia, but SB defined by computer usage time has not shown this association.</p><p><strong>Trial registration: </strong>CRD42023493109.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"451"},"PeriodicalIF":3.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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