BMC Psychiatry最新文献

{"title":"Effect of pilates on the physical and mental health of drug-dependent individuals - a randomized controlled trial.","authors":"Feng Ji, Ensong Zhou, Peng Zhao, Xinliang Chen, Hui Wang, Jiabin Zhong, Yi Zhang, Yunhang Lu, Qing Zhang","doi":"10.1186/s12888-025-07008-7","DOIUrl":"10.1186/s12888-025-07008-7","url":null,"abstract":"<p><strong>Objective: </strong>Drug-dependent individuals often face severe physical and mental health impairments, necessitating safe and adaptable rehabilitation strategies. This study aims to investigate the effects of Pilates exercise on the physical and mental health of drug-dependent individuals. Specifically, the study seeks to evaluate changes in body composition, physical fitness, blood biochemistry, and psychological outcomes following a structured Pilates intervention.</p><p><strong>Methods: </strong>This study was conducted as a double-blind, parallel-group, randomized controlled trial. A total of 43 substance-dependent individuals were recruited from the Judong Drug Rehabilitation Center and randomly assigned to either the Pilates intervention group (n = 22) or the control group (n = 21). The experimental group underwent Pilates program of two weekly sessions for 24 weeks, while the control group received conventional rehabilitation. We assessed physical and mental health indicators at baseline, 12, and 24 weeks. Repeated measures analysis of variance was employed to discern inter-group differences, and Spearman correlation analysis was applied to assess the relationship between fluctuations in scores on anxiety and depression scales and those of associated physiological metrics.</p><p><strong>Results: </strong>After 24 weeks of Pilates intervention, the intervention group showed significant improvements (p < 0.05) in body fat percentage, skeletal muscle mass, sit-and-reach distance, push-up performance, one-leg standing with eyes closed, vital capacity, white blood cell count, and neutrophil count. Psychological assessments revealed significant differences in scores on the Self-Rating Depression Scale (SDS) and Self-Rating Anxiety Scale (SAS) between the experimental and control groups (p < 0.01), with more pronounced effects in the experimental group. Additionally, changes in SDS scores were correlated with changes in sit-and-reach distance (r = -0.657, p < 0.001), one-leg standing with eyes closed (r = -0.734, p < 0.001), and vital capacity (r = -0.490, p = 0.001). Changes in SAS scores were correlated with changes in the neutrophil-to-lymphocyte ratio (r = -0.304, p = 0.048), platelet-to-lymphocyte ratio (r = -0.320, p = 0.037), sit-and-reach distance (r = -0.595, p < 0.001), one-leg standing with eyes closed (r = -0.704, p < 0.001), and vital capacity (r = -0.472, p = 0.001).</p><p><strong>Conclusion: </strong>The Pilates intervention significantly enhanced participants' physical attributes-body composition, strength, endurance, flexibility, balance, lung function, and immune response-while alleviating anxiety and depression. Correlations were identified between mental health improvements and physical gains, indicating that tailored exercise, informed by ongoing health monitoring, could optimize drug rehabilitation outcomes.</p><p><strong>Clinical trial registration: </strong>ChiCTR-IPR-2400087067, Registered on: 18/7/2024.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"559"},"PeriodicalIF":3.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building Emotional Awareness and Mental Health (BEAM): study protocol for a hybrid implementation-effectiveness trial of the BEAM app-based program for parents with clinical mental health problems.","authors":"Kaeley M Simpson, Robert J W McHardy, J Grace Zhou, Sydney Levasseur-Puhach, Cynthia M Côté, Millie Braun, Fiona Clement, Anna L MacKinnon, Nathan Nickel, Tracie O Afifi, Gerald F Giesbrecht, Ryan Giuliano, Laurence Y Katz, Lauren E Kelly, Terry P Klassen, Catherine Lebel, Aislin Mushquash, Kristin Reynolds, Elizabeth Decaire, Wajihah Mughal, Frances Chartrand, Olena Kloss, Jennifer M Hensel, James M Bolton, Jo Ann M Unger, Mandy Archibald, Philip Fisher, Ashley Pharazyn, Lianne Tomfohr-Madsen, Leslie E Roos","doi":"10.1186/s12888-025-06964-4","DOIUrl":"10.1186/s12888-025-06964-4","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Children are highly sensitive to adversity during their first five years of life, with exposure to chronic parental mental illness (MI) consistently linked to socio-emotional impairments and mental health problems in children. Children born during the COVID-19 pandemic were exposed to unprecedented levels of parental distress, with parental MI reported at three times the pre-pandemic rates. This situation underscored a pressing need for scalable solutions to foster positive mental health and developmental outcomes for a generation of children. In response, we developed the Building Emotional Awareness and Mental Health (BEAM) program, an innovative mobile health (mHealth) solution for parents of young children. Clinical trials to date evaluating BEAM have shown promising results, demonstrating reductions in parent depression, suicidality, anxiety, and harsh parenting practices. This trial involves an effectiveness-implementation hybrid design with co-primary aims of (1) determining BEAM's effectiveness in improving parent mental health, and (2) evaluating the implementation of BEAM in the community through metrics such as feasibility, acceptability, and uptake. This trial's secondary aim is to measure BEAM's effectiveness in improving short-term child mental health and developmental outcomes using primary data and long-term psychosocial family outcomes using administrative data. A final exploratory aim of this trial will measure the cost-utility of delivering BEAM relative to extant health programming.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A single arm trial with repeated measures will be used to evaluate the effectiveness of implementing the BEAM intervention in the community with a sample of 400 parent participants with a child aged 24-71 months. Participants must self-report moderate to severe symptoms of depression, anxiety, parenting stress, and/or anger at time of enrolment (T0) and live in the province of Manitoba, Canada. Individuals will be recruited through four streams including the (1) Manitoba Crisis Response Services, (2) primary care offices (paediatricians and/or general practitioners), (3) Manitoba family community organizations and child care centres, and (4) social media. Study participants will complete 12 weeks of psychoeducation modules, with access to an online social support forum and check ins with a peer coach. Assessments of parent and child mental health symptoms will occur at pre-test before BEAM begins (T1), immediately after the last week of the BEAM intervention (post-test, T2), 6-month follow-up (T3), and 12-month follow-up (T4).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;The BEAM program offers a promising solution to address elevated parental mental health symptoms, parenting stress, and related child functioning concerns. The present implementation trial aims to extend the groundwork established by an open pilot trial and RCT of the BEAM program, in a next step of testing BEAM's readiness for ","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"567"},"PeriodicalIF":3.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridge symptoms of insomnia, obsessive-compulsive symptoms, and depression/anxiety: a network analysis.","authors":"Shiqi Yuan, Ruiyang Wang, Yongyan Shi, Yixin Zhao, Haojuan Tao, Guowei Wu, Liwen Tan, Xuan Ouyang","doi":"10.1186/s12888-025-06998-8","DOIUrl":"10.1186/s12888-025-06998-8","url":null,"abstract":"<p><strong>Background: </strong>Insomnia has been associated with obsessive-compulsive disorder (OCD), as well as depression and anxiety. However, their interactions and the influence of depression and anxiety on this relationship remain unclear. We aimed to assess the bridge and central symptoms of the insomnia-obsessive-compulsive (OC) network model and explore the impact of depression and anxiety on these connections.</p><p><strong>Methods: </strong>A total of 1,046 patients were included in our study. The severity of insomnia, OC, depression, and anxiety were measured using the Pittsburgh Sleep Quality Index, Yale-Brown Obsessive-Compulsive Scale, Zung's Self-Rating Anxiety Scale, and Zung's Self-Rating Depression Scale, respectively. Stability analyses of marginal weights were conducted to assess network robustness.</p><p><strong>Results: </strong>The network analysis revealed that compulsive behaviors and low sleep quality were shown to be the most central symptoms in the insomnia-OC network, with compulsive behaviors and daytime dysfunction acting as bridge symptoms. Daytime dysfunction, obsessive thoughts, anxiety and panic were found to be bridge symptoms in the insomnia-OC-anxiety network. In the insomnia-OC-depression network, daytime dysfunction, obsessive thoughts, and rhythm disturbances were possible bridge symptoms.</p><p><strong>Conclusions: </strong>Compulsive behaviors and daytime dysfunction were linked to insomnia and OC. In the insomnia-OC-anxiety network, anxiety and panic played a central role, while depressed mood was prominent in the insomnia-OC-depression network model. Targeting compulsive behaviors and improving daytime functioning may help reduce insomnia in individuals with OCD. Additionally, addressing anxiety and panic, and rhythm disturbances may further alleviate the psychological distress in these patients.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"570"},"PeriodicalIF":3.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender as a sensor of nurses' depression, compassion fatigue and resilience.","authors":"Reem Ahmad Jarrad, Eman Al Hourani, Naser Ibrahim Mahmoud, Dua' Jum'a Al-Fayoumi","doi":"10.1186/s12888-025-07010-z","DOIUrl":"10.1186/s12888-025-07010-z","url":null,"abstract":"<p><strong>Background: </strong>Gender is a sensor in certain professional psychological risks. One of those professions is nursing; it has a humanistic nature that is double-loaded with triggers of negative psychological sequelae such as depression and compassion fatigue. To help male and female nurses cope successfully with variable trauma, resilience pathways are activated, yet using different mechanisms. The purpose of this study was to assess the differences in depression, compassion fatigue, and resilience based on gender and the variables of education, marital status, and income.</p><p><strong>Methods: </strong>631 hospital-based nurses participated in this correlational descriptive study. Measurements included a demographic survey, depression risk score measured by the Center for Epidemiologic Studies of Depression Scale (CESD), compassion fatigue score by Charles Figley, and resilience score measured by Connor-Davidson resilience scale-10 items. Analysis used descriptive statistics for gender, health sector, education, marital status, income, and department. Student t-test and ANOVA were used to investigate the differences in depression, compassion fatigue, and resilience based on gender, education, marital status, and income.</p><p><strong>Results: </strong>Male nurses significantly reported higher depression levels (t (629) = 4.8, p <.001, M = 29.1, SD = 10.3) than female nurses (M = 27.2, SD = 9.2). They reported significantly higher compassion fatigue (t (629) = 4.8, p <.001, M = 46,9, SD = 24.3) when compared to female nurses (M = 38.2, SD = 21.3). There was no gender-based difference in resilience scores between male (t = 0.037, P =.97 >.05), M = 23.7, SD = 7.8)) and female nurses (M = 23.7, SD = 8.2). There were no significant differences in depression, compassion fatigue, and resilience based on other demographic variables such as education, marital status, and income (p >.05). Depression had little negative relationship with resilience (r = -.116, p =.004) and a moderate positive relationship with compassion fatigue (r =.529, p <.001).</p><p><strong>Conclusion: </strong>Nurses' male gender showed dominance in depression and compassion fatigue over nurses' female gender. Resilience capabilities were generally the same between the two genders. Nevertheless, for both genders, compassion fatigue and depression risks were high and resilience scores were low. The negative relationship between depression and resilience suggests that health authorities should promote nurses' mental health to increase resilience capacities. Adopting gender-sensitive approaches in research and clinical practice in nurses' mental health is increasingly recommended with special cultural and contextual considerations.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"566"},"PeriodicalIF":3.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of resilience in the transition of suicidal indicators among Chinese children and adolescents: a nested case-control study.","authors":"Xin Tian, Linling Jiang, Shuqing Liu, Yandie He, Guiqing Zheng, Xinyi Liu, Xiang Wang, Yi Xiang, Jin Lu, Yuanyuan Xiao","doi":"10.1186/s12888-025-07013-w","DOIUrl":"10.1186/s12888-025-07013-w","url":null,"abstract":"<p><strong>Background: </strong>Pediatric suicide is a critical global public health issue. Discovering protective factors which can effectively block the progression from suicidal ideation (SI) to suicidal plan (SP) and suicidal attempt (SA) is essential for prevention. This study examined the role of resilience in preventing the transition of suicidal indicators among children and adolescents.</p><p><strong>Methods: </strong>A case-control study nested within a two-wave longitudinal survey was conducted in Yunnan province, China, involving 5,924 children and adolescents. Self-administered questionnaires were used to collect relevant information from the participants. Resilience was evaluated by using the Resilience Scale for Chinese Adolescents (RSCA), suicidal indicators (SI, SP, SA) were measured by the Modified Suicidal Behaviors Questionnaire-Revised (SBQ-R). Cases and controls were matched at a 1:3 ratio using propensity score matching. Univariate and multivariate logistic regression models were employed to examine the sequential associations between resilience and the suicidal indicators.</p><p><strong>Results: </strong>The two-wave survey revealed high transition rates from SI to SP (18.5%), SI to SA (7.75%), and SP to SA (11.13%). A 10-point increase in baseline resilience score was significantly associated with a 14% odds reduction in SI to SP progression (OR = 0.86, 95% CI: 0.75-0.99) and an 18% odds reduction in SI to SA progression (OR = 0.82, 95% CI: 0.69-0.96). Stratified analysis showed that resilience was most protective among adolescents, females, and those with baseline mood disorders. For the specific dimensions of resilience, emotion regulation demonstrated a protective effect in SI-SP transition, but not in SI-SA transition. Besides, family support played a prominent role in protecting against the progression from SI to SP among adolescents, minority groups, and subjects with baseline anxiety.</p><p><strong>Conclusions: </strong>The major findings of our study can provide important longitudinal evidence in guiding the construction of resilience-based suicide prevention strategies among vulnerable juvenile suicidal ideators.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"571"},"PeriodicalIF":3.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personality disorders in unipolar depressed inpatients: is patient perceived social support related to depression progression?","authors":"Bruno Perosa Carniel, Giulio Bertollo Alexandrino, Luísa Monteiro Burin, Pedro Henrico Grazziotin Portal, Neusa Sica da Rocha","doi":"10.1186/s12888-025-07039-0","DOIUrl":"10.1186/s12888-025-07039-0","url":null,"abstract":"<p><strong>Background: </strong>Unipolar depression (UD) and personality disorders (PD) often co-occur, impacting the prognosis of both conditions. A practical approach to UD must include the assessment of comorbid PD. We evaluated the prevalence of PD clusters in depressed inpatients, the prevalence of patients with comorbid PD at different stages of UD (1 - prodromal phase; 2 - first major depressive episode; 3 - residual phase; 4 - recurrent/double depression; and 5 - chronic major depressive episode), and compared the levels of social support (SS) between depressed inpatients with and without comorbid PD.</p><p><strong>Methods: </strong>Cross-sectional study with 150 inpatients diagnosed with UD with or without comorbid PD. We applied a staging model of UD for clinical staging. We used the Mini International Neuropsychiatric Interview instrument (MINI) to diagnose UD. The PD diagnosis was conducted through chart review and interviews using DSM-IV criteria. The Medical Outcomes Study's Social Support Scale (MOS-SSS) assessed levels of SS.</p><p><strong>Results: </strong>From the 150 patients with UD included in the study, 59 (39%) had comorbid PD, of which 33 (55.93%) were from cluster B, 8 (13.55%) were from cluster C, and 18 (30.5%) were cases of PD Not Otherwise Specified (NOS). Stage 5 (chronic major depressive episode) had a reduced rate of comorbid PD. Stages 3 (residual phase) and 4 (recurrent/double depression) had higher rates of comorbid PD. Levels of SS were lower in the comorbid group (UD + PD), in the Affectionate [UD + PD = 3.75 (SD = 1.13); UD = 4.17 (SD = 0.89), p = 0.031] and Tangible [UD + PD = 3.43 (SD = 1.21); UD = 3.94 (SD = 1.00), p = 0.02] domains of MOS-SSS.</p><p><strong>Conclusions: </strong>Cluster B was the most prevalent, and the most prevalent PD diagnosis was PD NOS. Comorbid PD is prevalent mainly in the residual and recurrent episode stages. Inpatients diagnosed with UD and comorbid PD have lower levels of SS compared to those without comorbid PD. These results have clinical implications, contributing to the awareness of the impact of comorbid PD and SS on the management of UD.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"560"},"PeriodicalIF":3.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of social perspectives in the relationship between suicidal ideation and depression among young women in slums of Kampala, Uganda.","authors":"Charles Natuhamya, Enid Nabukalu, Matthew Lyons, Kevin B Gittner, Jane Palmier, Rachel Culbreth, Monica H Swahn","doi":"10.1186/s12888-025-06930-0","DOIUrl":"10.1186/s12888-025-06930-0","url":null,"abstract":"<p><strong>Background: </strong>Multivariate analysis in suicidality research is of interest not only to identify the pathology of suicidality but also to understand the mechanisms of its treatment and to ascertain more efficient intervention strategies. The current study aimed to assess the roles of neighborhood factors, coping, and resilience in the association between depression and suicidal ideation in the understudied population of young women in the Kampala slum areas of Uganda.</p><p><strong>Methods: </strong>Data from the baseline assessment of \"The Onward Project On Wellbeing and Adversity\" (TOPOWA) research study were utilized during analysis. TOPOWA is a multi-component, prospective cohort study examining the mechanistic pathways of mental illness in the context of social determinants of mental health and lived experience among young women aged 18 to 24 years living in the urban slums of Kampala. The cohort comprises 300 women recruited in 2023 from 3 study sites (i.e., Banda, Bwaise, and Makindye). A path analysis hypothesizing the roles of neighborhood characteristics, coping, and resilience in the association between depression and suicidal ideation was modeled. Neighborhood characteristics in this study were typically neighborhood cohesion and neighborhood satisfaction.</p><p><strong>Results: </strong>The study findings demonstrated a significant role of resilience in the relationship between the neighborhood characteristics, depression, and suicidal ideation in a population where the prevalence of suicidal ideation (46.0%) and depression (57.8%) is substantial. Resilience was linked to reduced suicidal ideation (β = -0.02, p < 0.05) and depression (β = -0.14, p < 0.001).</p><p><strong>Conclusion: </strong>Intervention programs geared towards building resilience among young women in Uganda may reduce suicidal ideation directly or indirectly by decreasing depression, especially in urban slum settings.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"568"},"PeriodicalIF":3.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety and depression one year after the first stroke among Lebanese survivors: proportions, changes, and predictors.","authors":"Celina F Boutros, Walaa Khazaal, Maram Taliani, Najwane Said Sadier, Pascale Salameh, Hassan Hosseini","doi":"10.1186/s12888-025-06997-9","DOIUrl":"10.1186/s12888-025-06997-9","url":null,"abstract":"<p><strong>Background: </strong>About 1 in 2 stroke survivors suffer from anxiety and depression in the first year after stroke. This study aimed to calculate the proportions of 1-year post-stroke anxiety and depression (PSA and PSD), evaluate their changes over time, and identify the contributing factors among first-ever stroke survivors in Lebanon, where relevant research has been scarce.</p><p><strong>Methods: </strong>A hospital-based multicenter study was conducted among 150 subjects aged ≥ 18 years involving scheduled home visits at 3, 6, and 12 months after stroke index. Several scales were employed, including Hospital Anxiety and Depression Scale (HADS), Mini-Mental State Examination (MMSE), modified Rankin Scale (mRS), Short Form Health Survey (SF12), National Institutes of Health Stroke Scale (NIHSS), Visual Analogue Scale (VAS), Douleur Neuropathique 4 (DN4), Modified Ashworth Scale (MAS), and Fatigue Severity Scale (FSS), to assess levels of anxiety and depression, cognitive function, disability degree, quality of life, stroke severity, general pain, central pain, spasticity, and fatigue after stroke, respectively. Descriptive analyses were performed to describe baseline and stroke characteristics and to calculate proportions of PSA and PSD, followed by univariate and multivariable analyses to identify the contributing factors.</p><p><strong>Results: </strong>High HADS scores were reported in our cohort, with the most prevalent symptoms occurring within the first 3 months after stroke index (77.3% for PSD and 51.2% for PSA with HADS ≥ 8). Despite a slight decrease over the subsequent 6 and 12 months, proportions remained elevated, affecting at least 40% to 60% of survivors. PSA was a consistent independent predictor of PSD (Adjusted Odds Ratio ≅ 2). Other contributing factors to PSA and PSD were highlighted, including a history of atrial fibrillation, longer sedentary hours, high scores of NIHSS and mRS, lower scores of SF12 and MMSE, and the presence of immobility-related problems, of which high DN4 scores were independent predictors. Better 1-year psychological outcomes were noticed in those with higher educational levels and employment after stroke.</p><p><strong>Conclusion: </strong>Routine psychological screening and support for stroke survivors are urgently needed. By identifying factors and emphasizing early detection, our research offers valuable insights that can inform clinical practice and improve the well-being of stroke survivors.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"558"},"PeriodicalIF":3.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroleptic malignant syndrome in a patient with COVID-19 and the possible role of SARS-CoV-2 in its manifestation: case report and overview of published cases.","authors":"Tomas Skront, Jiri Sagan, Martin Hyza","doi":"10.1186/s12888-025-07032-7","DOIUrl":"10.1186/s12888-025-07032-7","url":null,"abstract":"<p><strong>Background: </strong>The manifestation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is more complex than that of pulmonary infection, and neuropsychiatric symptoms play a role in this complexity. In this paper, we present the case of a 29-year-old schizophrenic patient who suffered from neuroleptic malignant syndrome (NMS) that developed during coronavirus disease 2019 (COVID-19) infection, with an emphasis on the possible connection between these two conditions. Additionally, we provide an overview of published NMS cases in patients with COVID-19 or after vaccination against SARS-CoV-2.</p><p><strong>Case presentation: </strong>A 29-year-old patient treated for schizophrenia, treated with paliperidone palmitate (150 mg every four weeks) and cariprazine (6 mg daily), was admitted to the hospital for agitation and aggressivity; shortly after arrival at the hospital, laryngospasm and hypoxia occurred. The patient tested positive for SARS-CoV-2, and later, he developed pneumonia. During hospitalization, olanzapine (20 mg daily) was added to his regimen. However, due to continuing restlessness, haloperidol was administered (20 mg over the course of one day). A few days later, neuroleptic malignant syndrome occurred. He was treated with bromocriptine (15 mg daily) and clonazepam (2 mg daily) and recovered.</p><p><strong>Conclusions: </strong>As SARS-CoV-2 is known to interact with angiotensin-converting enzyme 2 and DOPA-decarboxylase is known to be coexpressed with this receptor, we hypothesized that COVID-19 infection might play a substantial role in the development of NMS.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"557"},"PeriodicalIF":3.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, genetic, and sociodemographic predictors of symptom severity after internet-delivered cognitive behavioural therapy for depression and anxiety.","authors":"Olly Kravchenko, Julia Bäckman, David Mataix-Cols, James J Crowley, Matthew Halvorsen, Patrick F Sullivan, John Wallert, Christian Rück","doi":"10.1186/s12888-025-07012-x","DOIUrl":"10.1186/s12888-025-07012-x","url":null,"abstract":"<p><strong>Background: </strong>Internet-delivered cognitive behavioural therapy (ICBT) is an effective and accessible treatment for mild to moderate depression and anxiety disorders. However, up to 50% of patients do not achieve sufficient symptom relief. Identifying patient characteristics predictive of higher post-treatment symptom severity is crucial for devising personalized interventions to avoid treatment failures and reduce healthcare costs.</p><p><strong>Methods: </strong>Using the Swedish multimodal database MULTI-PSYCH, we evaluated novel and established predictors associated with treatment outcome and assessed the added benefit of polygenic risk scores (PRS) and nationwide register data in a sample of 2668 patients treated with ICBT for major depressive disorder, panic disorder, and social anxiety disorder. Two linear regression models were compared: a baseline model employing six well-established predictors and a full model incorporating six clinic-based, 32 register-based predictors, and PRS for seven psychiatric disorders and traits. Predictor importance was assessed through bivariate associations, and models were compared by the variance explained in post-treatment symptom scores.</p><p><strong>Results: </strong>Our analysis identified several novel predictors of higher post-treatment severity, including comorbid ASD and ADHD, receipt of financial benefits, and prior use of psychotropic medications. The baseline model explained 27%, while the full model accounted for 34% of the variance.</p><p><strong>Conclusions: </strong>The findings suggest that a model incorporating a broad array of multimodal data offered a modest improvement in explanatory power compared to one using a limited set of easily accessible measures. Employing machine learning algorithms capable of capturing complex non-linear associations and interactions is a viable next step to improve prediction of post-ICBT symptom severity.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"555"},"PeriodicalIF":3.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}