BMC Psychiatry最新文献

{"title":"Subgrouping suicidal ideations: an ecological momentary assessment study in psychiatric inpatients.","authors":"Stephanie Homan, Zachary Roman, Anja Ries, Prabhakaran Santhanam, Sofia Michel, Anna-Marie Bertram, Nina Klee, Carlo Berther, Sarina Blaser, Marion Gabi, Philipp Homan, Hanne Scheerer, Michael Colla, Stefan Vetter, Sebastian Olbrich, Erich Seifritz, Isaac Galatzer-Levy, Tobias Kowatsch, Urte Scholz, Birgit Kleim","doi":"10.1186/s12888-025-06861-w","DOIUrl":"https://doi.org/10.1186/s12888-025-06861-w","url":null,"abstract":"<p><strong>Background: </strong>Suicidal ideation (SI) is one of the strongest predictors of suicide attempts, yet reliable prediction models for suicide risk remain scarce. A key challenge is that SI can fluctuate over time, potentially reflecting different subgroups that may offer important insights for suicide risk prediction. This study aims to build upon previous approaches that averaged SI trajectories by adopting a method that respects the temporal nature of SI.</p><p><strong>Methods: </strong>First, we applied longitudinal clustering to ecological momentary assessment (EMA) data on SI, with five daily assessments over 28 days from 51 psychiatric patients (61% female, mean age = 35.26, SD = 12.54). We used the KmlShape algorithm, which takes raw SI scores and the measurement occasion index as input. Second, we regressed each identified subgroup against established clinical risk factors for SI, including a history of suicidal thoughts and behaviors, hopelessness, depression diagnosis, anxiety disorder diagnosis, and history of abuse.</p><p><strong>Results: </strong>Four distinct subgroups with unique SI patterns were identified: (1) \"High SI, moderate variability\" (high mean, medium variability, high maximum); (2) \"Lowest SI, lowest variability\" (lowest mean, lowest variability, lowest maximum); (3) \"Low SI, moderate variability\" (low mean, medium variability, high maximum); and (4) \"Highest SI, highest variability\" (highest mean, highest variability, highest maximum). Furthermore, these subgroups were significantly associated with clinical characteristics. For instance, the subgroup with the least severe SI (\"lowest SI, lowest variability\") showed the lowest levels of hopelessness (beta = -0.95, 95% CI = -1.04, -0.86), whereas the subgroup with the most severe SI (\"highest SI, highest variability\") exhibited the highest levels of hopelessness (beta = 0.84, 95% CI = 0.72, 0.95).</p><p><strong>Conclusion: </strong>Applying longitudinal clustering to EMA data from patients with SI enables the identification of well-defined and distinct SI subgroups with clearer clinical characteristics. This approach is a crucial step toward a deeper understanding of SI and serves as a foundation for enhancing prediction and prevention efforts.</p><p><strong>Trial registration: </strong>10DL12_183251.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"469"},"PeriodicalIF":3.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recovery colleges as enablers of personal recovery: qualitative evaluation of the development of a recovery college in the Netherlands.","authors":"Thijs Beckers, Martijn Koopmans","doi":"10.1186/s12888-025-06917-x","DOIUrl":"https://doi.org/10.1186/s12888-025-06917-x","url":null,"abstract":"<p><strong>Background: </strong>In the Netherlands, maintaining high standards of mental healthcare faces challenges due to an increasing demand for mental healthcare and a focus on symptomatic recovery rather than personal growth and improvement in the quality of life. Recovery colleges, which emphasize personal recovery through hope, autonomy, and empowerment, offer a transformative approach by fostering an environment where individuals with mental distress can learn and thrive. The aim of this study was to explore the experiences of students and relevant stakeholders (like family members or regional social workers) with the recovery college.</p><p><strong>Methods: </strong>This study evaluated the experiences of students working on their personal recovery at the Recovery College Venlo, by utilizing qualitative methods including focus group interviews, personal interviews and thematic analyses.</p><p><strong>Results: </strong>The participants reported benefits such as enhanced personal growth and a reduction in self-stigma and reliance on traditional mental health services. Peer workers with lived experience were reported to play a pivotal role in facilitating recovery. Although recovery colleges show promise in supporting personal recovery and providing cost-effective alternatives to conventional mental health services, challenges remain in increasing awareness, accessibility, and family involvement. Further research is needed to optimize the implementation of recovery colleges and fully understand their effectiveness.</p><p><strong>Conclusions: </strong>The study underscores the importance of co-creation in the development of recovery-oriented services, and highlights areas for improvement, including enhanced family support and more streamlined access for potential students.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"465"},"PeriodicalIF":3.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of chronotype on depression in adolescents: the mediating role of sensation seeking and sleep quality.","authors":"Fangyi Wang, Ying Zhou, Xiao Hou, Shifen Ni, Xiaodi Xia, Tanwei Zhang, Yunyan Zhang, Xiangyu Li, Keyi Wen, Yutong Wang, Wenfen Zhu, Yixiao Fu","doi":"10.1186/s12888-025-06855-8","DOIUrl":"https://doi.org/10.1186/s12888-025-06855-8","url":null,"abstract":"<p><strong>Objectives: </strong>This study explores the relationships among chronotype, sensation seeking, sleep quality and depressive symptoms in adolescents with diagnosed depression, aiming to clarify the mechanisms by which chronotype is associated with depression.</p><p><strong>Methods: </strong>This cross-sectional study assessed 216 adolescents with diagnosed depression using a demographic questionnaire, the Morningness-Eveningness Questionnaire, the Sensation Seeking Scale, the Pittsburgh Sleep Quality Index, and the Beck Depression Inventory. Descriptive and correlational analyses were performed using SPSS 27.0, and structural equation modeling was conducted via AMOS to explore the mediating roles of sensation seeking and sleep quality in the relationship between chronotype and depression.</p><p><strong>Results: </strong>The study found that 60.6% of adolescents with depression were evening chronotypes. Evening chronotype was associated with higher sensation seeking (r = -0.134, p < 0.05), poorer sleep quality (r = -0.303, p < 0.01), and more severe depressive symptoms (r = -0.376, p < 0.01). Chronotype showed a direct effect on depressive symptoms (effect size = -0.318, 95% CI = -0.602 to -0.049, p < 0.05) and an indirect effect via sleep quality, accounting for 80.5% of the total effect. While sensation seeking alone was not a significant mediator, it contributed to a chain mediation with sleep quality, accounting for 13% of the total effect (combined effect size = -0.053, 95% CI = -0.163 to -0.005, p < 0.01).</p><p><strong>Conclusions: </strong>Chronotype may play a significant role in adolescent depression, with both direct and indirect effects mediated by sleep quality and sensation seeking. The findings highlight the potential importance of sleep quality as a mediating factor, indicating that interventions targeting sleep improvement could be a promising avenue for further exploration in alleviating depressive symptoms in adolescents.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"468"},"PeriodicalIF":3.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying serum lipidomic signatures related to prognosis in first-episode schizophrenia.","authors":"Mengyi Luo, Suzhen Zhang, Jingxin Xue, Tianhao Gao, Xuan Li, Zhaolin Zhai, Chang Lu, Yuke Dong, Kaiming Zhuo, Qiong Xiang, Qing Kang, Shunying Yu, Chunhong Shao, Dengtang Liu","doi":"10.1186/s12888-025-06802-7","DOIUrl":"https://doi.org/10.1186/s12888-025-06802-7","url":null,"abstract":"<p><strong>Background: </strong>Antipsychotic medications are crucial for alleviating symptoms of schizophrenia (SCZ). However, treatment responses vary across individuals, and few reliable biomarkers currently exist to predict the clinical outcome. Therefore, we aim to identify potential lipid markers for treatment outcomes in patients with first-episode SCZ.</p><p><strong>Methods: </strong>Pre-treatment serum samples were obtained from 95 participants who underwent an 8-week treatment regimen with antipsychotic drugs. Untargeted liquid chromatography-mass spectrometry (LC-MS) was used to acquire serum lipidomic profiles, correlating them with treatment responses at 8 weeks to identify potential lipid signatures. The antipsychotic treatment response was quantified using the percentage change on the Positive and Negative Syndrome Scale (PANSS) scale.</p><p><strong>Results: </strong>By combining LASSO regression and Random Forest regression, we identified 8 positively associated and 2 negatively associated baseline lipids related to the PANSS reduction rate. In the further analysis of logistic regression, we identified three candidate lipids, PC (18:2e_19:0), PE (53:7), and TG (16:2e_19:0_20:5), which could together distinguish poor and good responders, with an AUC of 0.805 (95% CI, 0.715-0.894).</p><p><strong>Conclusions: </strong>Our findings suggest that this set of lipid biomarkers may have the potential to predict the outcome of antipsychotic drug treatment. Further validation and larger studies are needed to evaluate their potential for clinical applications.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"467"},"PeriodicalIF":3.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hearing vocals to recognize schizophrenia: speech discriminant analysis with fusion of emotions and features based on deep learning.","authors":"Jie Huang, Yanli Zhao, Zhanxiao Tian, Wei Qu, Xia Du, Jie Zhang, Meng Zhang, Yunlong Tan, Zhiren Wang, Shuping Tan","doi":"10.1186/s12888-025-06888-z","DOIUrl":"https://doi.org/10.1186/s12888-025-06888-z","url":null,"abstract":"<p><strong>Background and objective: </strong>Accurate detection of schizophrenia poses a grand challenge as a complex and heterogeneous mental disorder. Current diagnostic criteria rely primarily on clinical symptoms, which may not fully capture individual differences and the heterogeneity of the disorder. In this study, a discriminative model of schizophrenic speech based on deep learning is developed, which combines different emotional stimuli and features.</p><p><strong>Methods: </strong>A total of 156 schizophrenia patients and 74 healthy controls participated in the study, reading three fixed texts with varying emotional stimuli. The log-Mel spectrogram and Mel-frequency cepstral coefficients (MFCCs) were extracted using the librosa-0.9.2 toolkit. Convolutional neural networks were applied to analyze the log-Mel spectrogram. The effects of different emotional stimuli and the fusion of demographic information and MFCCs on schizophrenia detection were examined.</p><p><strong>Results: </strong>The discriminant analysis results showed superior performance for neutral emotional stimuli compared to positive and negative stimuli. Integrating different emotional stimuli and fusing features with personal information improved sensitivity and specificity. The best discriminant model achieved an accuracy of 91.7%, sensitivity of 94.9%, specificity of 85.1%, and ROC-AUC of 0.963.</p><p><strong>Conclusions: </strong>Speech analysis under neutral emotional stimulation demonstrated greater differences between schizophrenia patients and healthy controls, enhancing discriminative analysis of schizophrenia. Integrating different emotions, demographic information and MFCCs improved the accuracy of schizophrenia detection. This study provides a methodological foundation for constructing a personalized speech detection model for schizophrenia.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"466"},"PeriodicalIF":3.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of electrolytes and complete blood count in adolescent depression with and without psychotic symptoms.","authors":"Xinyuan Li, Ziming Liu, Yanming Li, Xiuyu Jin, Shumin Zhu, Zining Liu, Xintong Pang, Yulan Geng","doi":"10.1186/s12888-025-06906-0","DOIUrl":"https://doi.org/10.1186/s12888-025-06906-0","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to investigate physiological differences in electrolytes and complete blood counts in adolescent patients with depression with and without psychotic symptoms. By comparing baseline data in adolescent patients, it will provide more comprehensive information for individualised diagnosis and treatment of depression.</p><p><strong>Methods: </strong>Clinical baseline data of adolescent patients were collected, including information on gender, age, smoking history, and alcohol consumption history. In terms of electrolytes and complete blood counts, the differences between the two groups of patients were compared, and a predictive model was constructed by stepwise logistic regression, and its diagnostic value was evaluated by ROC.</p><p><strong>Results: </strong>Ca, WBC and NE were relevant factors for the development of psychotic symptoms in adolescents (Ca: OR = 21.95; WBC: OR = 1.16; NE: OR = 1.18). The three indicators and the constructed predictive model 1 performed poorly in the ROC curve in adolescent patients, with an AUC of 0.598.</p><p><strong>Conclusion: </strong>Blood calcium plays an important role in adolescent depression with psychotic symptoms. And leukocytes, neutrophils in depression with psychotic symptoms as an indicator of inflammation suggestive indicators for treatment and mechanism studies.</p><p><strong>Limitations: </strong>This study was a cross-sectional study. The study population was Chinese adolescents and did not include adolescents from other regions.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"459"},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-designing a peer support programme for carers of people treated under the Mental Health Act: views from stakeholders.","authors":"Imogen Wells, Kelly Wintsch, Abigail G-Medhin, Brynmor Lloyd-Evans, Steve Gillard, Rose McCabe, Mohamed Yaasir Mohamudbucus, Candelaria Mahlke, Katharina Nagel, Zhenreenah Muhxinga, Swaran Singh, Stefan Priebe, Domenico Giacco","doi":"10.1186/s12888-025-06851-y","DOIUrl":"https://doi.org/10.1186/s12888-025-06851-y","url":null,"abstract":"<p><strong>Background: </strong>Relatives/friends (carers) of people who are involuntarily admitted to a psychiatric hospital report high levels of stress, feelings of isolation and exclusion from their patient's care. One-to-one peer support is widely implemented for patients, facilitating mental health recovery. Preliminary evidence reports that peer support may benefit carers too, but a one-to-one peer support programme to help carers when their relatives/friends are in hospital has not been developed.</p><p><strong>Objective: </strong>To explore carers', patients', and professionals' views on what an accessible, feasible and helpful one-to-one peer support intervention should consider for carers of patients treated under the Mental Health Act (MHA) in England.</p><p><strong>Method: </strong>Nineteen one-to-one interviews were conducted online with five carers, four patients, four clinicians, four independent mental health advocates and two behaviour change experts. Participants had experience of either being treated or supporting someone treated under the MHA within the last 10 years. Audio recordings of the interviews were transcribed, and data were analysed using thematic analysis.</p><p><strong>Results: </strong>Five themes were identified: (a) carer availability and awareness; (b) peer support flexibility; (c) early promotion of peer support; (d) appropriate training and support for peers, and; (e) anticipated impact of peer support. Carers' lack of time and awareness of support were reported as key barriers to accessing peer support. To address this, participants emphasised the need for early introduction of support following patients' hospitalisation and flexible delivery through various communication channels. They also highlighted the need for robust, interactive training for peer supporters. Expected benefits included improved carer and peer supporter wellbeing and increased carer knowledge and empowerment.</p><p><strong>Conclusions: </strong>These findings highlight the need for structured training for peer supporters and a flexible, accessible peer support programme for carers. The findings can inform evidence-based co-production of a carer peer support programme for use in England, which could improve carer wellbeing, knowledge and empowerment.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"460"},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White matter hyperintensities, inflammation and cognitive impairments in drug-naïve first episode schizophrenia patients: a cross-sectional study.","authors":"Yan Zhang, Xiuxia Yuan, Yu Zhang, Yishao Chen, Keju Su, Kangkang Xue, Suying Ding, Jingfeng Chen, Xiaoduo Fan, Xueqin Song","doi":"10.1186/s12888-025-06905-1","DOIUrl":"https://doi.org/10.1186/s12888-025-06905-1","url":null,"abstract":"<p><strong>Background: </strong>Studies have reported that white matter hyperintensities (WMHs) are associated with disturbances in immune function, and the relationship between WMHs and cognitive impairments have been documented in various clinical populations. The present study was to examine the relationship between WMHs, immune function, and cognitive impairments in patients with schizophrenia (SCH) remains unknown.</p><p><strong>Methods: </strong>A sample of 127 drug-naïve first episode SCH and 72 healthy controls (HCs) were included in this study. Serum levels of cytokines and oxidative stress indices were measured using enzyme-linked immunosorbent assay and microtiter plate method. WMHs were assessed using T2-weighted magnetic resonance imaging scanning, and cognitive performance was evaluated using the MATRICS Consensus Cognitive Battery.</p><p><strong>Results: </strong>We found patients with SCH are more likely to present with WMHs compared with HCs (OR = 2.076, 95%CI 1.007-4.277, p = 0.048). SCH with WMHs displayed more pronounced cognitive deficits in domains including speed of processing, working memory, verbal learning, visual learning, reasoning, and problem-solving compared with patients without WMHs (p < 0.05). Correlation analysis showed that the volume of WMHs was negative correlated with the problem-solving score (r=-0.331, p = 0.042) in patients with SCH. Within the SCH group, patients with WMHs exhibited elevated levels of interleukin-2 (IL-2), reactive oxygen species (ROS), and superoxide dismutase (SOD), along with lower levels of serum interleukin-4 (IL-4) and interferon-γ (IFN-γ) compared with those without WMHs (p < 0.05). The mediation analyses demonstrated that serum levels of IFN-γ in SCH had fully indirect effects on cognitive function, mediated by the WMHs.</p><p><strong>Conclusions: </strong>This study suggests that WMHs may play a vital mediating role in the relationship between inflammation, oxidative stress, and cognitive impairments in SCH. Future studies exploring the potential clinical utility of WMHs as biomarkers for early detection and intervention of SCH are warranted.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"462"},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between red blood cell distribution width-to-albumin ratio and depression: a cross-sectional analysis among US adults, 2011-2018.","authors":"Yao Zhou, Lijuan Zhao, Yunzhu Tang, Shuxia Qian","doi":"10.1186/s12888-025-06907-z","DOIUrl":"https://doi.org/10.1186/s12888-025-06907-z","url":null,"abstract":"<p><strong>Background: </strong>Red blood cell distribution width (RDW)-to-albumin ratio (RAR) is a novel index. Its relationship with depression, a common and complex psychiatric disorder, remains unclear. This study utilized the National Health and Nutrition Examination Survey (NHANES) database to investigate this relationship.</p><p><strong>Methods: </strong>Multivariate logistic regression, restricted cubic spline (RCS) regression, receiver operating characteristic (ROC) analysis, and sensitivity analyses were used to examine the relationship between RAR and depression based on NHANES data from 2011-2018. The study also used subgroup analyses and interaction tests to explore whether the relationship was stable across populations.</p><p><strong>Results: </strong>RAR was positively associated with depression in 18,150 participants aged ≥ 20 years. In fully adjusted models, each one-unit increase in RAR was associated with a 22% increase in the likelihood of depression [1.22 (1.05, 1.41)]. Participants in the highest quartile of RAR had a 30% higher risk of depression than those in the lowest quartile of RAR [1.30 (1.04, 1.63)]. Subgroup analyses revealed that the association between RAR and depression was significantly stronger among men, alcohol-drinking and high-income groups.</p><p><strong>Conclusions: </strong>Higher baseline RAR was associated with an increased risk of depression in US adults and was more informative than RDW, albumin, and hemoglobin-to-RDW ratio (HRR). Further large-scale prospective studies are needed to analyze the role of RAR in depression. These findings emphasize that RAR can be a simple, reliable and cost-effective predictor of depression in clinical practice.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"464"},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resilience revisited: a systematic review and synthesis of Non-Suicidal Self-Injury (NSSI) and its relation with resilience.","authors":"Daphne Weedage, Nienke Kool-Goudzwaard, Dwayne Meijnckens, Robert R J M Vermeiren, Cyril Boonmann","doi":"10.1186/s12888-025-06868-3","DOIUrl":"https://doi.org/10.1186/s12888-025-06868-3","url":null,"abstract":"<p><strong>Background: </strong>The aim of the current study is to examine the relationship between nonsuicidal self-injury (NSSI) and resilience. Resilience has been identified as a critical area for further investigation in the context of NSSI. Resilience has been conceptualized in different ways over the years, from psychological resilience, with a focus on the individual's problem/deficiency, into a dynamic, cultural, interactive process in which people's biological, psychological, social, and ecological systems work together to help them cope with challenges and maintain or improve their mental well-being.</p><p><strong>Method: </strong>For this systematic review was searched within PubMed, PsycINFO, the Cochrane Library, and Web of Science for currently published studies on the relationship between NSSI and resilience to provide a summary, following the Preferred Reporting Items for Meta-analysis and Meta-Analysis. Second, it determines the magnitude of this relationship by calculating a random effects size, using the meta-package of R.</p><p><strong>Results: </strong>Included were 17 studies with a total sample size of 12,273 participants (M_age = 17.56, range: 12.93-27.50, SD = 3.95; female: 59.5%) and a NSSI sample size of 4,767 (38.8%). The pooled results indicate a small to moderate relationship between resilience and NSSI, with a random effects model effect size of 0.28 (95% CI: 0.10; 0.47), with higher levels or the presence of NSSI associated with lower levels of resilience. Most studies measured psychological resilience. Several reporting the moderator and mediator function of resilience, whereby higher resilience reduces the odds of developing NSSI in the case of stressful or traumatic events. A minority of studies reported effect sizes per resilience factor. Of which problem solving/coping and emotional reactivity were predominantly reported.</p><p><strong>Conclusions: </strong>Resilience is related to NSSI. However, it also shows that resilience is mostly measured as a psychological and individual concept. This is contrary to the multimodal perspective of resilience as well as the multimodal and non-linear nature of the recovery process of NSSI. Therefor this review highlights the need for a holistic approach with a shift in focus to a multimodal perspective. More research is needed to understand the role of resilience within the nonlinear recovery process. This research should include the voices of people with lived experience.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"463"},"PeriodicalIF":3.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}