BMC Psychiatry最新文献

{"title":"Effect of olanzapine on changes in serum complement factors levels in patients with first-episode schizophrenia.","authors":"Yin Cao, Xuan Zhou, Chunyu Yan, Jun Liang, Biao Dai, Qingrong Xia","doi":"10.1186/s12888-025-07369-z","DOIUrl":"10.1186/s12888-025-07369-z","url":null,"abstract":"<p><strong>Objective: </strong>An increasing number of studies have demonstrated that patients with schizophrenia (SCZ) exhibit complement system disorders, and alterations in serum complement factor levels may serve as biomarkers for guiding the diagnosis, prognosis, and treatment of SCZ. Olanzapine is an atypical antipsychotic medication known for its immune-regulatory and anti-inflammatory properties. In this study, we evaluated alterations in serum complement factor levels in patients with first-episode SCZ, explored their diagnostic biomarker potential, and examined the impact of olanzapine treatment on these complement profiles.</p><p><strong>Methods: </strong>A cohort of 35 individuals with first-episode SCZ and 35 healthy controls were included in this study. The severity of psychiatric symptoms in individuals with SCZ was assessed using the Brief Psychiatric Rating Scale-18 Item Version (BPRS) and the Scales for the Assessment of Negative Symptoms (SANS) and Positive Symptoms (SAPS). A panel of 5 serum complement-related assays, namely measurements of complement components (C1, C2, C3, C4) and assessment of total complement activity via the 50% hemolytic complement (CH50) test, was performed using commercially available enzyme-linked immunosorbent assay (ELISA) kits. The levels of serum complement factors in healthy controls and individuals with SCZ were compared at baseline. All patients received olanzapine at a dosage range of 10-20 mg/day for a duration of 4 weeks. The BPRS, SANS, SAPS scores, and serum complement factor levels were compared before and after olanzapine treatment.</p><p><strong>Results: </strong>Serum C2, C3, C4 levels, and CH50 activity were significantly higher in patients with first-episode SCZ compared to healthy controls (P < 0.05). A combined panel of C1, C2, C3, C4, and CH50 demonstrated high accuracy in differentiating patients with SCZ from healthy controls, with a sensitivity of 91.4%, specificity of 77.1%, and AUC = 0.926. Moreover, there was a positive correlation between SANS scores and serum C3 levels (r = 0.357, P = 0.036), while BPRS scores were negatively correlated with serum C4 levels (r = -0.397, P = 0.018) at baseline. Furthermore, significant reductions were observed in SAPS scores (t = 4.795, P < 0.001), SANS scores (t = 3.809, P = 0.001), and BPRS scores (t = 8.538, P < 0.001) after treatment. Additionally, after 4 weeks of treatment, serum levels of C2 (t = 11.812, P < 0.001), C3 (t = 7.649, P < 0.001), and C4 (t = 2.902, P = 0.006) decreased significantly, whereas the CH50 activity increased significantly (t = -9.202, P < 0.001) compared to pre-treatment levels.</p><p><strong>Conclusion: </strong>These findings demonstrate the potential of olanzapine to reduce serum levels of complement factors C2, C3, and C4 while increasing serum CH50 activity in patients with first-episode SCZ. However, the exact mechanism underlying this regulatory effect remains unclear and warrants further investigation.","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"959"},"PeriodicalIF":3.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between components of the biosafety incident response competence for clinical nursing staff: a network analysis.","authors":"Chao Wu, Ning Zha, Kai Zhang, Shuai He, Jing He, Mimi Fu, Xinyan Zhang, Hongjuan Lang","doi":"10.1186/s12888-025-07438-3","DOIUrl":"10.1186/s12888-025-07438-3","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"956"},"PeriodicalIF":3.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trauma exposure among individuals with mood disorders: a cross-sectional study at a tertiary psychiatric facility in Uganda.","authors":"Joan Abaatyo, Emmanuel Alol, Mark Mohan Kaggwa","doi":"10.1186/s12888-025-07457-0","DOIUrl":"10.1186/s12888-025-07457-0","url":null,"abstract":"<p><strong>Background: </strong>Mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD), are prevalent psychiatric conditions globally. Exposure to trauma has been shown to exacerbate the severity and chronicity of mood disorders. In low-resource settings like Uganda, where trauma exposure is widespread and mental health services are limited, understanding the trauma-mood disorder relationship is essential but under-researched.</p><p><strong>Aims: </strong>This study aimed to assess the prevalence and typology of trauma exposure among individuals with mood disorders attending a tertiary psychiatry unit in Uganda and to explore correlates of trauma history.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among 221 adults diagnosed with mood disorders at Mbarara Regional Referral Hospital between April and June 2023. Participants were assessed for trauma exposure using the Stressful Life Events Screening Questionnaire (SLESQ), and suicidality was evaluated using the Columbia-Suicide Severity Rating Scale (C-SSRS). Socio-demographic and clinical variables were collected, and data were analyzed using descriptive statistics, chi-square tests, t-tests, and logistic regression.</p><p><strong>Results: </strong>Among 221 participants, 72.0% reported lifetime trauma, most commonly crime-related events (95.6%). Physical abuse was significantly more common in bipolar disorder than in major depression. Older age and family history of suicide attempt independently predicted trauma exposure.</p><p><strong>Conclusion: </strong>Trauma exposure, especially crime-related, is highly prevalent among Ugandan patients with mood disorders. Findings highlight the need for routine trauma screening and trauma-informed care in psychiatric services.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"963"},"PeriodicalIF":3.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical surface area as a stronger mediator of the waist-to-height ratio and cognitive impairment link in patients with first-episode schizophrenia compared to body mass index and waist-hip ratio.","authors":"Chen Lin, Yi Yin, Mengzhuang Gou, Shujuan Pan, Jinghui Tong, Yanfang Zhou, Ting Xie, Ting Yu, Yanli Li, Yimin Cui, Zhiren Wang, Xingguang Luo, Ping Zhang, Junchao Huang, Song Chen, Yunlong Tan","doi":"10.1186/s12888-025-07458-z","DOIUrl":"10.1186/s12888-025-07458-z","url":null,"abstract":"<p><strong>Objective: </strong>The high metabolic risk and inherent brain structural changes in patients with schizophrenia are associated with cognitive impairment; however, the underlying mechanism remains unclear. This study investigated whether cortical surface area (CSA) and cortical thickness (CT) mediate obesity-related cognitive impairment in patients with first-episode schizophrenia (FEPS).</p><p><strong>Methods: </strong>We included 160 patients with FEPS and 150 healthy controls (HCs). Cognitive function and psychiatric symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS) and the Chinese version of the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB). The CSA and CT of 34 grey matter regions in each hemisphere were measured using 3.0-T magnetic resonance imaging. Obesity metrics included waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), and body mass index (BMI).</p><p><strong>Results: </strong>HCs had significantly higher CSA and CT in several brain regions than FEPS after adjusting for covariates (p < 0.05). WHR significantly correlated with Verbal Learning, Working Memory, and MCCB composite scores, while WHtR was linked to Social Cognition and MCCB composite scores (p < 0.05). Bilateral CSA mediated the associations between WHR, WHtR, and MCCB scores (p < 0.05), with stronger mediation observed for WHtR. Right inferior parietal gyrus CSA specifically mediated WHR and WHtR links to cognitive outcomes.</p><p><strong>Conclusions: </strong>CSA, particularly in the right inferior parietal gyrus, mediates the relationship between obesity metrics and cognitive function. WHtR may be a more reliable marker than BMI or WHR for assessing abdominal obesity's impact on cognition, offering insights into the mechanisms of cognitive deficits in schizophrenia.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"962"},"PeriodicalIF":3.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maintenance pharmacotherapy after electroconvulsive therapy in inpatients with major depressive disorder: 198 prescriptions in a real-world clinical setting.","authors":"Shun Igarashi, Takashi Tsuboi, Naomi Hasegawa, Shinichiro Ochi, Kazutaka Ohi, Kentaro Fukumoto, Jun-Ichi Iga, Hiroyuki Muraoka, Hitoshi Iida, Fumitoshi Kodaka, Shusuke Numata, Kayo Ichihashi, Hiroko Kashiwagi, Toshinori Nakamura, Hirotaka Yamagata, Masahiro Takeshima, Tatsuya Nagasawa, Junya Matsumoto, Hisashi Yamada, Hikaru Hori, Ken Inada, Norio Yasui-Furukori, Ryota Hashimoto, Koichiro Watanabe","doi":"10.1186/s12888-025-07445-4","DOIUrl":"10.1186/s12888-025-07445-4","url":null,"abstract":"<p><strong>Background: </strong>Although antidepressant monotherapy is recommended for patients with major depressive disorder (MDD), they often do not respond to it, necessitating alternatives such as electroconvulsive therapy (ECT). However, maintenance pharmacotherapy after ECT has remained unestablished. This study, conducted at 240 facilities throughout Japan, aimed to explore maintenance pharmacotherapy after ECT for 3,749 inpatients with MDD.</p><p><strong>Methods: </strong>The patients were divided into two groups, one that underwent ECT (ECT group, N = 521) and another that did not (non-ECT group, N = 3,273), for the comparison of clinical characteristics and prescription details at discharge. The primary outcome of this study was the prescription rate of antidepressant monotherapy at discharge, while the secondary outcomes included prescription rates of specific combination regimens, such as antidepressant plus lithium.</p><p><strong>Results: </strong>We identified 198 prescription patterns involving antidepressants in the ECT group. Analysis by drug category revealed distinctive patterns: there was no statistically significant difference in prescription rates for antidepressant monotherapy between the ECT and non-ECT groups (N = 118, 22.6% vs. N = 932, 28.4%). In contrast, the prescription rate for the combination of antidepressant and antipsychotic medications was significantly higher in the ECT group (N = 188, 36.0% vs. N = 941, 28.7%). The combination of antidepressant and mood stabilizer was also more frequent in the ECT group (N = 35, 6.7% vs. N = 130, 3.9%), although this difference did not reach statistical significance after Bonferroni correction. At the drug level, additional distinctive patterns emerged: among antidepressant monotherapies, nortriptyline use was significantly more common in the ECT group (N = 9, 1.7% vs. N = 11, 0.3%). For mood stabilizers, restricting the analysis to lithium revealed a markedly higher rate in the ECT group (N = 30, 5.7% vs. N = 35, 1.0%).</p><p><strong>Conclusions: </strong>These findings highlight the complexity of treatment decisions managing of MDD after ECT and emphasize the need for structured prospective research on the effectiveness of specific maintenance pharmacotherapies after ECT.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"957"},"PeriodicalIF":3.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden and prediction study of schizophrenia 1990-2030: comparison with China.","authors":"Zhou Yuan, Chen Bai, Yue Li, Jin Zhang, Ping Yu, Fei Jiang","doi":"10.1186/s12888-025-07168-6","DOIUrl":"10.1186/s12888-025-07168-6","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to assess and predict global and Chinese schizophrenia burden trends from 1990 to 2030.</p><p><strong>Methods: </strong>Retrieve data from the 2021 Global Burden of Disease Study to estimate the incidence, prevalence, and disability-adjusted life years (DALYs) of schizophrenia from 1990 to 2021. Establish a joint point analysis and Bayesian age-period-cohort (BAPC) model to predict the burden of schizophrenia in 2030.</p><p><strong>Result: </strong>In 2021, the global prevalence of schizophrenia was approximately 13.60 million cases, with an age-standardized rate of 275.78 per 100,000 population. The global incidence was around 1.2 0million cases, with a rate of 15.43 per 100,000, and the global DALYs totaled 14.80 million, with a rate of 177.75 per 100,000. In China, the prevalence was about 5.30 million cases (300.81 per 100,000), the incidence was 236,175 cases (18.36 per 100,000), and DALYs were 3.40 million (203.88 per 100,000). From 1990 to 2021, China's age-standardized prevalence and DALY rates increased, with estimated annual percentage change (EAPCs) of 0.12 and 0.04. However, the global age-standardized incidence rate also decreased, with an EAPC of -0.04. Using the BAPC model, forecasts indicate a rising trend in both global and Chinese schizophrenia prevalence, incidence, and DALYs from 2020 to 2030. By 2030, the global age-standardized prevalence, incidence, and DALYs are projected to reach 280.36, 15.59, and 177.31 per 100,000, respectively. In China, these rates are expected to reach 332.58, 19.87, and 216.67 per 100,000.</p><p><strong>Conclusion: </strong>The global burden of schizophrenia is increasing, particularly in China, where the trend is especially pronounced. In response to this trend, Mental health education and early identification measures should be promoted for high-burden populations, especially young adults aged 20-34, while mental health support services for men should be strengthened and more gender-sensitive treatment and rehabilitation pathways should be designed. As future burden projections continue to rise, policymakers should optimize resource allocation, accordingly, incorporate research data into mental health planning, and improve accessibility and equity of services for key populations, in order to promote more targeted intervention strategies and effectively alleviate the social and family burden of schizophrenia.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"955"},"PeriodicalIF":3.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subregional amygdala functional connectivity abnormalities and anhedonia impairments in first-episode schizophrenia.","authors":"Qijie Kuang, Sumiao Zhou, Guangxing Deng, Nvnan Zhou, Xiangzhu Zeng, Hengyu Zhang, Yongjie Deng, Yingjun Zheng, Shenglin She","doi":"10.1186/s12888-025-07363-5","DOIUrl":"10.1186/s12888-025-07363-5","url":null,"abstract":"<p><strong>Background: </strong>Although abnormal amygdala functional connectivity (FC) has been reported in schizophrenia, most studies have treated the amygdala as a single structure. This study aimed to explore the association between amygdala subregional FC and anhedonia in patients with first-episode schizophrenia (FES).</p><p><strong>Methods: </strong>Resting-state functional magnetic resonance imaging (fMRI) was conducted in 31 FES patients (including 11 drug-naïve) and 33 matched healthy controls (HCs). Clinical symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS), and anhedonia was evaluated via the Snaith-Hamilton Pleasure Scale (SHAPS). Whole-brain FC analyses of amygdala subregions were performed, followed by group comparisons and correlation analyses with anhedonia scores.</p><p><strong>Result: </strong>Compared to HCs, FES patients showed significantly reduced FC between specific amygdala subregions and cortical regions, particularly within the frontal, temporal, parietal, and limbic lobes (P < 0.05, GRF correction). Anhedonia severity was positively correlated with altered FC in the centromedial (CM) subregion of the amygdala (AMY_CM), especially with the supplementary motor area (SMA) and paracentral lobule (PLG). Notably, the association between right AMY_CM and right SMA FC and anhedonia remained significant after adjusting for clinical symptom severity (r = 0.46, P = 0.02).</p><p><strong>Conclusions: </strong>FES patients exhibit disrupted FC between amygdala subregions and cortical areas, with specific patterns linked to anhedonia. These findings suggest that anhedonia may be associated with a potential neurobiological marker independent of general clinical symptoms and may be indicative of amygdala-cortical dysconnectivity in schizophrenia.</p><p><strong>Trial registration: </strong>Data used for this analysis came from case-control studies.</p><p><strong>Clinical trial number: </strong>not applicable. (April 2018 through March 2021).</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"960"},"PeriodicalIF":3.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating pain and pleasure: trauma and alcohol use among urban women in India.","authors":"Krisha Balsarkar, Ketoki Mazumdar","doi":"10.1186/s12888-025-07326-w","DOIUrl":"10.1186/s12888-025-07326-w","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"961"},"PeriodicalIF":3.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12512580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of different forms of single moderate-intensity exercise on inhibitory function and instant emotion of undergraduate students with depressive symptoms: a randomized controlled trial based on ERP.","authors":"Feng Gao, Shuqi Jia, Suowang Yin, Zhaosong Yin, Wei Guan, Feng Ding, Xing Wang, Ping Wan","doi":"10.1186/s12888-025-07310-4","DOIUrl":"10.1186/s12888-025-07310-4","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"950"},"PeriodicalIF":3.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CATATOnia treatment with transcranial direct current electrostimulation: protocol of a randomised, double-blind, placebo-controlled bicentric superiority study (CATATOES).","authors":"Mylène Moyal, David Attali, Alice Le Berre, Noomane Bouaziz, Anton Iftimovici, François Ramon, Adèle Henensal, Louise Dahan, Laetitia Canivet, Ghita Dadi, Clément Debacker, Maliesse Lui, Sylvain Charron, Anaëlle Alouit, Khaoussou Sylla, Rossella Letizia Mancusi, Thierry Gallarda, Arnaud Cachia, Martine Gavaret, Boris Chaumette, Catherine Oppenheim, Dominique Januel, Marion Plaze, Alexandre Haroche","doi":"10.1186/s12888-025-07266-5","DOIUrl":"10.1186/s12888-025-07266-5","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"949"},"PeriodicalIF":3.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12506329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}