BMC Psychiatry最新文献

{"title":"Feasibility and acceptability of the Unified Protocol for anxiety and depression in Pakistan: a pilot randomized controlled trial.","authors":"Asma Nisa, Salma Siddiqui, Amantia A Ametaj","doi":"10.1186/s12888-026-08345-x","DOIUrl":"10.1186/s12888-026-08345-x","url":null,"abstract":"<p><strong>Background: </strong>Access to evidence-based psychological treatments for common mental health disorders remains limited in low-resource settings. This pilot randomized controlled trial evaluated the feasibility and acceptability of the Urdu Adapted Unified Protocol (UA-UP), a transdiagnostic cognitive-behavioral intervention for anxiety and depression, in Pakistan, and explored preliminary clinical outcomes.</p><p><strong>Methods: </strong>51 adults meeting diagnostic criteria for anxiety and/or depressive disorders were randomized to a 14-week UA-UP intervention (n=25) or a waitlist control (n=26). Feasibility was assessed through recruitment, retention, and adherence rates. Acceptability was evaluated via session attendance, homework completion, participant satisfaction (CSQ-8), and qualitative feedback. Clinical outcomes (anxiety, depression, emotion regulation, and functional impairment) were assessed using validated measures. Between-group differences were analyzed using repeated-measures general linear models, and 95% confidence intervals were reported.</p><p><strong>Results: </strong>Feasibility indicators were high, with recruitment (85.7%), retention (82.4%), and strong session adherence. Acceptability was supported by 79% homework completion and high satisfaction (mean CSQ-8=29.65, SD=2.60). Participants in the UA-UP group demonstrated greater improvements in anxiety, depression, and functional impairment compared to the control group, with large effect size estimates (e.g., anxiety g=1.18; depression g=1.15). Qualitative findings indicated enhanced emotional awareness, improved coping, and strong engagement with culturally adapted content.</p><p><strong>Conclusions: </strong>The UA-UP demonstrated high feasibility and acceptability as a culturally adapted transdiagnostic CBT intervention in Pakistan. These findings support the conduct of a fully powered randomized controlled trial to evaluate clinical effectiveness and inform scalable implementation in low-resource settings.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov, NCT06002087. Registered 03 August 2023 (retrospectively registered). https://clinicaltrials.gov/study/NCT06002087?term=Asma%20Nisa&rank=1 .</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"26 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13595706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of progressive muscle relaxation training in post-traumatic stress disorder after the Kahramanmaraş earthquake: a randomized controlled trial.","authors":"Tuğba Karadaşlı, Mesut Arslan","doi":"10.1186/s12888-026-08676-9","DOIUrl":"10.1186/s12888-026-08676-9","url":null,"abstract":"<p><strong>Background: </strong>The February 6, 2023 Kahramanmaraş earthquake was one of Turkey's most devastating natural disasters, causing serious psychological issues, especially Post-Traumatic Stress Disorder (PTSD). Although various treatments exist for PTSD, they can be costly and sometimes ineffective. Progressive Muscle Relaxation Training (PMRT) is a low‑cost, self‑administered technique with no side effects, but randomized controlled trials on its effectiveness for post‑earthquake PTSD remain very limited. This randomized trial examined whether PMRT effectively treats PTSD in individuals after the Kahramanmaraş earthquake.</p><p><strong>Methods: </strong>The study included 44 earthquake-affected individuals aged 18-65 who met at least one of the following criteria: formal DSM-5 PTSD diagnosis by a psychiatrist, or a PCL-5 score of 47 or higher (indicating clinically significant PTSD symptoms). Based on power analysis, 22 participants were assigned to each group via block randomization: PMRT and control. All received PTSD and healthy lifestyle information; those on ongoing treatment continued. The PMRT group additionally received 6 weeks (twice/week, 20-30 min/session) of telerehabilitation-based PMRT. Assessments (PCL-5, DASS-21, PSQI, FSS, SF-36) were conducted pre- and post-intervention. Time-group interactions were analyzed with two-way mixed ANOVA (p < 0.05).</p><p><strong>Results: </strong>In the PMRT group, PTSD symptom severity significantly decreased after the intervention (p < 0.001; η²p = 0.735). Significant improvements were also observed in depression (η²p = 0.435), anxiety (η²p = 0.521), stress (η²p = 0.504), sleep quality (η²p = 0.632), fatigue (η²p = 0.477), and both physical (η²p = 0.727) and mental (η²p = 0.630) components of quality of life compared to the control group (p < 0.001). In the control group, no significant changes were observed in these parameters, while sleep quality and physical health deteriorated in the control group.</p><p><strong>Conclusion: </strong>PMRT was associated with greater improvements in PTSD symptoms, psychological well-being, sleep quality, fatigue, and quality of life compared to an education-only control group. Telerehabilitation may offer a practical advantage when face-to-face care is limited, although this remains speculative.</p><p><strong>Clinical trial registration number: </strong>NCT07164261-02.09.2025.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"26 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13685207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149236897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mediating role of brain structural-functional connectivity coupling in linking paternal education to BMI and depressive scores in young adults.","authors":"Yuhui Wang, Cancan Lin, Wenjie Xia, Xiao Zhang, Shutang Zhao, Tiefeng Ji, Xubo Wang, Defu Zhang, Yue Wang, Yuxin Du, Hao Yu, Shanling Ji","doi":"10.1186/s12888-026-08360-y","DOIUrl":"10.1186/s12888-026-08360-y","url":null,"abstract":"<p><strong>Background: </strong>Parental education is associated with body mass index (BMI), mental health, and neurodevelopment in young adults, yet the neurobiological mechanisms remain unclear. This study investigated whether parental education is related to BMI and depressive scores through brain structural-functional connectivity (SC-FC) coupling.</p><p><strong>Methods: </strong>This study included 490 healthy young adults who underwent resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) scans. Parental education was measured as years of schooling, BMI by weight/height², and depressive scores by the Beck Depression Inventory-II (BDI). SC and FC were derived from DTI and rs-fMRI, respectively. SC-FC coupling was quantified using Spearman's correlation between SC and FC matrices. Associations among variables were examined using Pearson correlation and mediation analyses.</p><p><strong>Results: </strong>Paternal education was significantly correlated with BMI (r = 0.10, P < 0.05) and depressive scores (r = -0.09, P < 0.05). Additionally, paternal education, BMI, and depressive scores were positively associated with SC-FC coupling in the right inferior parietal lobule (IPL, r = 0.19, corrected P < 0.001; r = 0.12, corrected P < 0.05; r = 0.10, corrected P < 0.05, respectively). Mediation analysis showed that the right IPL statistically mediated the associations of paternal education with both BMI (indirect effect = 0.01, 95% confidence interval (CI): 0.001-0.04) and depressive scores (indirect effect = 0.01, 95% CI: 0.001-0.03).</p><p><strong>Conclusion: </strong>In this cross-sectional study, paternal education was associated with BMI and depressive scores, with SC-FC coupling in the right IPL statistically mediating these associations. No corresponding effects were observed for maternal education. These findings suggest a potential neural pathway linking socioeconomic factors to physical and mental health outcomes.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"26 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13587411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letting patients lead? Practitioners' experiences of using DIALOG+ in psychosis outpatient care - patient involvement, collaborative dynamics, and professional roles.","authors":"Marcus Lundmark, Matilda Cederberg, Ann-Christine Andersson, Andreas Gremyr","doi":"10.1186/s12888-026-08633-6","DOIUrl":"10.1186/s12888-026-08633-6","url":null,"abstract":"<p><strong>Background: </strong>Severe mental illness, such as psychosis, significantly affects many areas of life. Involving patients in their care may enhance engagement and support recovery by ensuring that treatment focuses on their expressed needs. DIALOG+ is an intervention, supported by a digital tool, aimed at facilitating patient involvement in treatment by incorporating self-assessment and a problem-solving approach during routine clinical encounters and promoting a collaborative and patient-centred approach to care. The aim of this study was to explore mental health practitioners' (MHPs) experiences of how DIALOG+ influenced patient involvement and the dynamics of collaboration in outpatient psychosis care.</p><p><strong>Methods: </strong>A qualitative study was designed to describe MHPs' experiences of using DIALOG+ in psychosis outpatient care in Sweden. Fourteen MHPs who had used DIALOG+ three times or more were included in the study. Four focus groups were conducted using semi-structured interviews and analysed through reflexive thematic analysis.</p><p><strong>Results: </strong>The analysis of MHPs' experiences resulted in three themes: \"The patient's voice and engagement,\" \"The relationship between patient and mental health practitioner,\" and \"Professional challenges and changes in the practitioner's role.\" DIALOG+'s structured approach made it easier for patients to express their needs and take a more active role in the conversation, sometimes leading to increased patient engagement. The intervention also seemed to balance the conversation by sharing responsibility for decisions and follow-up between patients and practitioners. At the same time, practitioners reflected on challenges when letting the patient lead the conversation, which could result in time constraints and the need to balance patient-led agendas with professional responsibility.</p><p><strong>Conclusion: </strong>DIALOG+ has the potential to support the operationalisation of co-production in outpatient psychosis care by increasing patients' influence over the agenda in routine clinical encounters. It provides a structured framework for shared reflection and action planning, while also making visible potential differences between patients' preferences and practitioners' clinical assessments that can be negotiated. However, its impact depends on how the approach is enacted in practice. Supporting practitioners in navigating shifts in professional roles and authority may therefore be important for realising the full potential of the intervention.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"26 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13651122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of depression and anxiety in patients with inborn errors of immunity: a cross-sectional study.","authors":"Luca J Wolff, Torsten Witte, Kai G Kahl, Anna Meinecke, Gerrit Ahrenstorf, Georgios Sogkas, Stefanie Hillmer, Thea Thiele","doi":"10.1186/s12888-026-08654-1","DOIUrl":"10.1186/s12888-026-08654-1","url":null,"abstract":"<p><strong>Background: </strong>Inborn errors of immunity are chronic, genetically caused disorders that impair immune function and often increase susceptibility to infection. Many patients self-isolate because of infection-related concerns, which may increase the risk of mental health problems. This study evaluated symptoms of depression and anxiety and the need to address mental health in primary care.</p><p><strong>Methods: </strong>In this cross-sectional study in Germany, fatigue, pain and quality of life were assessed using visual analogue scales. Routine clinical data including diagnosis, psychiatric comorbidities and susceptibility to infections were collected. Symptoms of depression and anxiety were evaluated using the PHQ-9 and GAD-7 questionnaires. Statistical analyses were performed to examine differences in self-isolation frequency and its association with pre-existing mental illness.</p><p><strong>Results: </strong>A total of 143 patients (88 women and 55 men, mean age 45.4 years, range 21-85) were included. The median PHQ-9 score was 5 (IQR 8) and the median GAD-7 score was 5 (IQR 7). Eleven of 140 patients with PHQ-9 scores of at least 10 had no psychiatric diagnosis. Overall, 26% of patients with relevant symptoms had not received a diagnosis or treatment. Patients who self-isolated because of infection concerns had significantly higher PHQ-9 (Spearman's ρ = 0.52, p < 0.001) and GAD-7 scores (Spearman's ρ = 0.48, p < 0.001).</p><p><strong>Conclusions: </strong>Self-isolation was associated with more severe symptoms of depression and anxiety, including in patients without known psychiatric disease. These findings highlight the need for greater awareness of mental health issues and multidisciplinary care in patients with inborn errors of immunity.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"26 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13576266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of the Constructive Aggression Behavioral System (CABS) is associated with poor short- and long-term treatment outcomes and readmission among patients with major depression: a naturalistic study.","authors":"Reinhard Maß, Kerstin Backhaus, Kevin Pütz, Michael Szelies","doi":"10.1186/s12888-026-08490-3","DOIUrl":"10.1186/s12888-026-08490-3","url":null,"abstract":"<p><strong>Background: </strong>The Constructive Aggression Behavioral System (CABS) has been conceptualized as an evolutionarily grounded pattern of behavior that enables individuals to assert their needs, interests, and boundaries in a non-violent and socially adaptive manner. It is theoretically distinct from destructive forms of aggression. Inhibition of CABS has been proposed as a clinically relevant construct in emotional disorders. The present study aimed to examine the role of CABS inhibition in treatment outcomes and longer-term prognosis in patients with major depressive disorder (MDD).</p><p><strong>Methods: </strong>A total of 416 inpatients diagnosed with MDD were assessed using the Aggressionshemmungs-Inventar (AHI) to measure CABS inhibition and the revised Beck Depression Inventory (BDI-II) at admission and discharge. Three hierarchical multiple regression analyses were conducted to examine whether AHI scores at discharge were associated with change in depressive symptoms from admission to discharge and whether they predicted depressive symptoms at 6-month follow-up as well as psychiatric readmission within one year. Covariates included age, gender, suicidality, unemployment, comorbid anxiety, and antidepressant use.</p><p><strong>Results: </strong>At admission, patients showed elevated AHI scores (mean z = 1.40), indicating substantial inhibition of constructive aggression. During treatment, both depressive symptoms and AHI scores decreased significantly. AHI scores at discharge were associated with symptom change during treatment and with depressive symptoms at 6-month follow-up as well as readmission within one year.</p><p><strong>Conclusions: </strong>The findings indicate that CABS inhibition represents a clinically relevant correlate of treatment outcome and is associated with follow-up outcomes in MDD. Given the observational design, the results do not allow conclusions regarding causal effects. Future longitudinal and experimental studies are needed to examine whether changes in CABS inhibition are associated with changes in clinical outcomes and to further clarify its potential role in the onset and maintenance of emotional disorders.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"26 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13576321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of avatar identity on level-2 visual perspective taking in individuals with schizophrenia.","authors":"Pei Xie, ChaoZheng Huang, Li Lu, HanBin Sang, AiBao Zhou","doi":"10.1186/s12888-026-08614-9","DOIUrl":"10.1186/s12888-026-08614-9","url":null,"abstract":"<p><strong>Background: </strong>This study investigated whether individuals with schizophrenia (SZ) exhibit impairments in Level-2 visual perspective-taking (VPT)-the ability to understand how a scene appears from another's viewpoint-and if using a self-represented avatar could mitigate these deficits.</p><p><strong>Methods: </strong>Two experiments were conducted. Experiment 1 (N = 63) used a digit inversion task to assess Level-2 VPT based on object appearance. Experiment 2 (N = 62) used a round-table task to assess it based on spatial location. Participants with SZ and healthy controls (HC) performed both tasks under two conditions: using a 'self-avatar' and an 'other-avatar'.</p><p><strong>Results: </strong>Individuals with SZ demonstrated significant Level-2 VPT impairments in both experiments. Compared to HC, the SZ group showed significantly lower accuracy and a stronger egocentric bias, particularly in perspective-incongruent conditions. Critically, the self-avatar identity did not produce a selective performance benefit in the SZ group.</p><p><strong>Conclusions: </strong>The findings confirm pervasive Level-2 VPT deficits in schizophrenia across different task domains. The absence of a schizophrenia-specific self-avatar benefit suggests that an instruction-based self-avatar manipulation alone may be insufficient to selectively improve Level-2 VPT performance in schizophrenia. The cognitive mechanisms underlying this pattern remain to be established.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"26 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13576246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-stigma and suicide cognitions in substance use disorder: the mediating role of psychological distress and the moderating role of social support.","authors":"Zehra Uçar Hasanlı, Mehmet Rıdvan Varlı, Mustafa Batuhan Kurtoğlu, Kübra Sezer Katar, Gamze Zengin İspir, Mustafa Danışman","doi":"10.1186/s12888-026-08349-7","DOIUrl":"10.1186/s12888-026-08349-7","url":null,"abstract":"<p><strong>Background: </strong>Individuals with substance use disorders (SUD) experience substantial psychological and social difficulties. A prominent concern is the internalization of stigmatizing societal attitudes, leading to feelings of guilt and worthlessness. This self-stigma has been linked to depression, anxiety, and stress and may contribute to suicide-related cognitions. This study aimed to examine the relationship between self-stigma and suicide cognitions, and to evaluate the potential mediating roles of psychological distress (depression, anxiety, and stress), as well as the moderating role of perceived social support.</p><p><strong>Methods: </strong>In this cross-sectional study, 270 adults receiving treatment for SUD at a specialized addiction center were recruited, and analyses were conducted on 265 participants with complete data. Participants completed the Substance Abuse Self-Stigma Scale, Suicide Cognitions Scale-Revised, Depression Anxiety Stress Scale-21, and Multidimensional Scale of Perceived Social Support. Pearson correlations were followed by parallel multiple mediation and moderation analyses using 5000 bootstrap resamples.</p><p><strong>Results: </strong>Self-stigma was positively associated with depression, anxiety, stress, and suicide cognitions, and negatively associated with perceived social support. In the mediation model, only depression significantly mediated the relationship between self-stigma and suicide cognitions, whereas anxiety and stress did not emerge as significant mediators when entered simultaneously. Moderation analyses indicated that perceived support from family, friends, and a significant other each attenuated the association between self-stigma and suicide cognitions, indicating a buffering effect.</p><p><strong>Conclusion: </strong>These findings underscore the clinical importance of routinely assessing self-stigma and depression in SUD populations due to their predisposition to suicidal cognitions. Interventions aimed at reducing self-stigma, enhancing self-worth, and increasing perceived social support should be considered integral components of suicide prevention strategies in this high-risk group.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"26 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13563716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148954954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life's essential 8 health profiles and risk of incident neuropsychiatric diseases: a nationwide prospective cohort study.","authors":"Huihui Huangfu, Haiyi Jia, Chen Chen, Yunyi Xu, Xinke Zhou, Yilin Tang, Xiang Gao","doi":"10.1186/s12888-026-08341-1","DOIUrl":"10.1186/s12888-026-08341-1","url":null,"abstract":"<p><strong>Background: </strong>Although previous studies have established associations between Life's Essential 8 (LE8) and neuropsychiatric diseases, they predominantly operationalised the LE8 as a composite score, assuming equal weighting and potentially obscuring heterogeneity in health behaviour patterns. Therefore, this study applied latent profile analysis (LPA) to identify distinct LE8 profiles and examined their associations with the incidence of neuropsychiatric diseases.</p><p><strong>Methods: </strong>The sample comprised 242,947 UK Biobank participants without prevalent neuropsychiatric diseases. LE8 comprises eight components: healthy diet, physical activity, nicotine exposure, sleep health, glucose, blood lipid, blood pressure, and body mass index. LPA was utilized to identify distinct health patterns. Cox proportional hazards models were used to examine the associations between LE8 profiles and disease incidence.</p><p><strong>Results: </strong>LPA identified five distinct profiles: Low LE8 score; Elevated adiposity, blood pressure, and glucose group; Low physical activity with poor sleep group; Elevated blood pressure and dyslipidaemia group; and High LE8 score group. Over a median follow-up of 13.8 years, 11,419 cases of anxiety, 341 cases of bipolar disorder, and 40 cases of schizophrenia were identified. Using the Low LE8 score group as a reference, all four comparison profiles exhibited significant protective associations for both anxiety (Hazard Ratio [HR] range: 0.65-0.78, all p < 0.001) and bipolar disorder (HR range: 0.37-0.51, all p < 0.001), with risk reductions of up to 35% and 63%, respectively. No significant associations were observed for schizophrenia, likely due to the small number of incident cases (n= 40), and these findings should be considered exploratory.</p><p><strong>Conclusions: </strong>Distinct LE8 profiles showed heterogeneous associations with neuropsychiatric disease risk, with healthier profiles linked to lower anxiety and bipolar disorder risk, while schizophrenia findings remained inconclusive. These results support person-centred, pattern-based approaches over composite scoring for neuropsychiatric risk stratification and hypothesis generation.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"26 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13560367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148928867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study protocol of a randomized controlled trial for the effectiveness of psychomotor therapy on quality of life and psychomotor skills in depression.","authors":"Gabrielle Pouilloux, Margaux Henault, Théodore Vinais, Nicolas Bodeau, Benjamin Laplace, Aude Paquet","doi":"10.1186/s12888-026-08347-9","DOIUrl":"10.1186/s12888-026-08347-9","url":null,"abstract":"<p><strong>Background: </strong>Psychomotor disturbances, such as cognitive-motor and sensory deficits, are well documented in Major Depressive Disorder (MDD). Although they impact quality of life, they remain insufficiently assessed and targeted in clinical practice. Psychomotor therapy (PMT) appears promising for improving functioning and quality of life, but strong evidence from randomized controlled trials (RCT) in adults with MDD is still lacking.</p><p><strong>Methods: </strong>This multicenter, prospective RCT aims to assess the effectiveness of a PMT on the quality of life and psychomotor functioning in adults with MDD. 128 participants diagnosed with MDD will be randomized into either the intervention group (GP) or the control group (GC). The GP will receive 12-weeks of a PMT in addition to standard care, while the GC will receive standard care with a weekly telephone follow-up. Sociodemographic, clinical, and psychomotor data will be collected at baseline and then again at 1, 3, and 6 months to serve as primary and secondary outcome measures. These data will be used to evaluate improvements in quality of life, as well as changes in depressive and anxiety symptoms, psychomotor slowing, anhedonia, self-esteem, and overall psychomotor functioning, including body image, interoception, and sensory processing. Therapeutic alliance and adherence to the PMT will also be monitored throughout the intervention.</p><p><strong>Discussion: </strong>This study is the first RCT assessing the benefits of PMT on the quality of life of MDD patients. This study could justify the prescription of PMT for patients with depression and support the inclusion of psychomotor therapists in multidisciplinary teams in adult psychiatry.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier: NCT06234176 on 2024-01-15.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"26 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13556074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148918417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}