BMC Psychiatry最新文献

{"title":"Measurement invariance and comparison of the mobile phone dependence questionnaire (MPDQ) across mainland Chinese and Hong Kong adolescents.","authors":"Hanbin Wang, Fung Chin, Chun Chen","doi":"10.1186/s12888-025-07057-y","DOIUrl":"10.1186/s12888-025-07057-y","url":null,"abstract":"<p><strong>Background: </strong>Mobile phone dependence (MPD) is a serious public health concern in schools. To advance cross-cultural understanding of MPD, this study examined factor structure, measurement invariance, and latent mean differences of the mobile phone dependence questionnaire (MPDQ) across mainland Chinese and Hong Kong adolescents.</p><p><strong>Methods: </strong>The present cross-sectional study included a total of 918 middle school students (588 boys and 310 girls; M_age = 13.58, SD = 1.46), comprising 367 adolescents from two Shenzhen schools and 551 adolescents from three Hong Kong schools. Confirmatory factor analysis, measurement invariance test, latent mean comparisons, and multidimensional item response theory analysis were employed for data analyses.</p><p><strong>Results: </strong>The three-factor structure of the MPDQ, proposed by previous research conducted in Hong Kong adolescents, was also supported in mainland Chinese adolescents. Configural, partial metric, and partial scalar cross-cultural measurement invariance were all achieved. Mainland Chinese adolescents reported higher scores on all MPD factors than their Hong Kong counterparts.</p><p><strong>Conclusions: </strong>The findings highlight the cross-cultural similarities and differences of MPD among adolescents in mainland China and Hong Kong. The MPDQ is culturally sensitive to measure MPD in both regions, while certain items may need further cultural adaptation. Moreover, Hong Kong adolescents demonstrated more disordered thoughts and behaviors associated with MPD than mainland Chinese adolescents. Implications for using the MPDQ for assessing and understanding the MPD from diverse cultural backgrounds are discussed.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"575"},"PeriodicalIF":3.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of online mindfulness-based stress reduction training on depression and anxiety symptoms among psychiatric healthcare workers in a randomized controlled trial: the mediating role of emotional suppression.","authors":"Yuekun Wu, Yue Ban, Guoliang Pan, Mingyang Yao, Li Liu, Ting Chen, Hui Wu","doi":"10.1186/s12888-025-06967-1","DOIUrl":"10.1186/s12888-025-06967-1","url":null,"abstract":"<p><strong>Background: </strong>Psychiatric healthcare workers experience prolonged exposure to psychological trauma and negative emotions, which ultimately predisposes them to mental health issues. The effectiveness of online mindfulness-based stress reduction training on depression and anxiety symptoms among psychiatric healthcare workers (HCWs) and the possible mechanisms that benefit these outcomes remain unclear.</p><p><strong>Methods: </strong>This randomized controlled trial evaluated the effect of an 8-week online MBSR among psychiatric HCWs (165 participants) at the mental health center in Shenyang, China from August to November 2022, compared with the waitlist control group. The effective sample size that actually completed the intervention was 135 (74 participants in the intervention group and 61 in the control group), and the loss-to-follow-up rate was approximately 18%. Participants completed assessments of depression and anxiety symptoms (Hospital Anxiety and Depression Scale, HADS), and emotional suppression (Courtauld Emotional Control Scale, CECS) at baseline and week 8 online via the \"Wenjuanxing\" Platform. Intervention outcomes were estimated via analysis of covariance (ANCOVA). Multiple linear regression and mediation models with bias-corrected bootstrapping were performed to explore the mediating role of emotional suppression.</p><p><strong>Results: </strong>Compared with those in the control group, the participants in the online MBSR group presented lower emotional suppression (P < 0.001), symptoms of depression (P < 0.001) and anxiety (P = 0.002). The decrease in emotional suppression mediated the effects of online MBSR on 8-week symptoms of depression (indirect effect = - 1.106, 95% CI [- 1.683, - 0.600]) and anxiety (indirect effect = - 1.182, 95% CI [- 1.731, - 0.706]).</p><p><strong>Conclusions: </strong>Online MBSR training could be utilized to alleviate depression and anxiety symptoms in psychiatric HCWs. It might weaken depression and anxiety symptoms by reducing emotional suppression. Emotional suppression might be the key change process of the effects of online MBSR on depression and anxiety symptoms in psychiatric HCWs.</p><p><strong>Trial registration: </strong>The clinical trial registration code was obtained from the Chinese Clinical Trial Registry (date of registration: 02/08/2022, registration number: ChiCTR2200062347).</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"577"},"PeriodicalIF":3.4,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning for classification of pediatric bipolar disorder with and without psychotic symptoms based on thalamic subregional structural volume.","authors":"Weijia Gao, Kejing Zhang, Qing Jiao, Linyan Su, Dong Cui, Shaojia Lu, Rongwang Yang","doi":"10.1186/s12888-025-07018-5","DOIUrl":"10.1186/s12888-025-07018-5","url":null,"abstract":"<p><strong>Background: </strong>The thalamus plays a crucial role in sensory processing, emotional regulation, and cognitive functions, and its dysregulation may be implicated in psychosis. The aim of the present study was to examine the differences in thalamic subregional volumes between pediatric bipolar disorder patients with (P-PBD) and without psychotic symptoms (NP-PBD).</p><p><strong>Methods: </strong>Participants including 28 P-PBD, 26 NP-PBD, and 18 healthy controls (HCs) underwent structural magnetic resonance imaging (sMRI) scanning using a 3.0T MRI scanner. All T1-weighted imaging data were processed by FreeSurfer 7.4.0 software. The volumetric differences of thalamic subregions among three groups were compared by using analyses of covariance (ANCOVA) and post-hoc analyses. Additionally, we applied a standard support vector classification (SVC) model for pairwise comparison among the three groups to identify brain regions with significant volumetric differences.</p><p><strong>Results: </strong>The ANCOVA revealed that significant volumetric differences were observed in the left pulvinar anterior (L_PuA) and left reuniens medial ventral (L_MV-re) thalamus among three groups. Post-hoc analysis revealed that patients with P-PBD exhibited decreased volumes in the L_PuA and L_MV-re when compared to the NP-PBD group and HCs, respectively. Furthermore, the SVC model revealed that the L_MV-re volume exhibited the best capacity to discriminate P-PBD from NP-PBD and HCs.</p><p><strong>Conclusion: </strong>The present findings demonstrated that reduced thalamic subregional volumes in the L_PuA and L_MV-re might be associated with psychotic symptoms in PBD.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"574"},"PeriodicalIF":3.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of the attention training technique delivered in groups as treatment for anxiety and depression in patients with coronary heart disease: a qualitative study.","authors":"Kristoffer Tunheim, Costas Papageorgiou, Hanne C Lie, John Munkhaugen, Toril Dammen","doi":"10.1186/s12888-025-07027-4","DOIUrl":"10.1186/s12888-025-07027-4","url":null,"abstract":"<p><strong>Background: </strong>Clinically significant anxiety and depression symptoms are common in patients with coronary heart disease (CHD) and associated with a range of negative outcomes. Preliminary evidence suggests that the attention training technique (ATT), a component of metacognitive therapy (MCT), delivered in a group format, is feasible and potentially effective in reducing symptoms of anxiety and depression in these patients. Patients' experiences of treatment including facilitators and barriers are useful in order to further develop effective intervention. We are not aware of any previous qualitative studies conducted on ATT in patients with CHD. Our study aimed to assess the treatment experiences in these patients.</p><p><strong>Methods: </strong>Patients (N = 10) with CHD and significant symptoms of anxiety and/or depression, who participated in a randomized controlled trial of the effectiveness of ATT delivered in a group format, were recruited to in-depth, individual interviews three months after treatment completion. The interviews were recorded, transcribed and analysed according to the principles of thematic analysis.</p><p><strong>Results: </strong>Nine males and one female participated, with a mean age of 54.3 (range 45-63) years. Mean time since cardiac event was 54.2 months. We identified two main themes; non-specific ATT treatment factors and group ATT-specific treatment factors. Furthermore, non-specific ATT treatment factors included subthemes relating to individual and group factors. These subthemes encompassed the (relational aspects such as the) interaction between the group patients, interaction between the patients and the therapist, and the therapist's delivery of the group ATT. Second, specific ATT treatment factors included subthemes concerning understanding and making sense of the technique and treatment, changes in relation to thoughts and thinking, and group format as a facilitator of ATT treatment.</p><p><strong>Conclusions: </strong>Group ATT was perceived as helpful among outpatients with CHD in terms of symptom relief. Both general and ATT specific factors were regarded important, and the patients seemed to understand ATT in a way that is consistent with the rationale of ATT treatment. All patients emphasized the importance of the group format.</p><p><strong>Trial registration: </strong>The study was approved by the Regional Committee of Ethics (REK) South East Norway (REK 52002) and by the data protection officer at Drammen Hospital (20/04048-1/005). The study is registered at clinicaltrials.gov (Identifier NCT05621408).</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"573"},"PeriodicalIF":3.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Memantine augmentation of escitalopram in treatment of executive function among patients with obsessive-compulsive disorder (OCD): a double-blind placebo-controlled randomized clinical trial.","authors":"Hasan Mirzazadeh, Younes Ghaeminia, Amin Mohamad Niaei, Mohammadsadegh Kamran, Leila Razeghian Jahromi, Reza Moshfeghinia","doi":"10.1186/s12888-025-06856-7","DOIUrl":"10.1186/s12888-025-06856-7","url":null,"abstract":"<p><strong>Background: </strong>Obsessive-Compulsive Disorder (OCD) involves persistent, intrusive thoughts and repetitive behaviors. While SSRIs like escitalopram are common treatments, some patients do not respond adequately. This study aims to assess memantine's effectiveness as an adjunct therapy to enhance executive function in OCD patients.</p><p><strong>Methods: </strong>This study was a 16-week, randomized, double-blind, placebo-controlled clinical trial to evaluate if adding memantine to escitalopram helps treat OCD. A total of 60 participants were recruited from Namazi Hospital and Ibn Sina Polyclinic in Shiraz, Iran. Participants were randomly divided into two groups: the control group received escitalopram plus placebo, and the intervention group received escitalopram plus memantine. The main outcome, the severity of OCD symptoms, was measured using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), and executive function was assessed using the Barkley Deficits in Executive Functioning Scale (BDEFS). Safety was checked weekly using the Drug Adverse Event Questionnaire. Data were analyzed using SPSS, with a significance level set at p < 0.05.</p><p><strong>Results: </strong>All sixty participants completed the 16 weeks of the study. Thirty participants per group (Placebo, Memantine) showed no significant differences in age, gender, or education (P > 0.05) at baseline. Both groups showed significant reductions in Y-BOCS scores (P < 0.001), with the Placebo group decreasing from 32.83 (SD = 4.04) to 5.30 (SD = 3.18) and the Memantine group from 31.60 (SD = 2.62) to 5.20 (SD = 2.62) without difference between groups (P = 0.12). Notebale Improvements in executive function were observed, particularly in time management, where Memantine outperformed Placebo (P = 0.03). Other domains showed no significant differences. Adverse events were minimal; gastrointestinal symptoms were rare, with Memantine showing a higher incidence but not statistically significant.</p><p><strong>Conclusion: </strong>The study found that while both treatment regimens significantly alleviated OCD symptoms, memantine did not provide notable advantages over escitalopram alone, except in time management. Further research is needed to assess long-term effects and mechanisms of this combination therapy.</p><p><strong>Trial registration: </strong>IRCT20211118053093N5, 25/06/2025.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"561"},"PeriodicalIF":3.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep disturbance as a marker of postpartum psychosis risk: a prospective actigraphy study.","authors":"Chiara Petrosellini, Sofia H Eriksson, Nicholas Meyer, Edwin Antony, Olivia Protti, Lucinda Donaldson, Vincent van Hees, Aviva Petrie, Andrew McQuillin, Dimitrios Siassakos","doi":"10.1186/s12888-025-07017-6","DOIUrl":"10.1186/s12888-025-07017-6","url":null,"abstract":"<p><strong>Background: </strong>Postpartum Psychosis (PP) is a severe perinatal psychiatric disorder affecting 1-2 in 1000 individuals following childbirth. Most episodes emerge within the first two weeks postpartum and commonly present with mania and decreased need for sleep. The postnatal period is a time of profound sleep disruption and sleep deprivation is a known trigger for mania and psychosis. Despite growing recognition of the role of sleep in the onset and progression of PP, this relationship remains poorly understood. Existing research is largely retrospective, relies on self-reported data and primarily focuses on women with pre-existing bipolar disorder. This prospective study will integrate subjective and objective sleep measures to investigate the relationship between sleep disturbance and postnatal mania. We aim to establish whether sleep patterns in late pregnancy or the early postpartum period can predict mania as a marker of PP.</p><p><strong>Methods: </strong>This prospective observational cohort study is recruiting pregnant women and will follow participants from the late third trimester until two weeks postpartum. We aim to recruit 100 participants, including individuals with and without psychiatric illness, to ensure broader applicability of the findings and capture the full spectrum of postnatal mania risk. Participants will wear a wrist accelerometer continuously during this period to monitor rest-activity patterns and infer objective sleep parameters including sleep duration, efficiency and fragmentation. Self-reported sleep quality and mood symptoms will be measured using the Pittsburgh Sleep Quality Index (PSQI), Altman Self-Rating Mania Scale (ASRM) and Edinburgh Postnatal Depression Scale (PSQI) at baseline and at days 3-5 and 12-14 postpartum. Actigraphy data will be analysed using the GGIR package in R. Associations between sleep measures and ASRM scores will be assessed using Pearson and Spearman correlation coefficients.</p><p><strong>Discussion: </strong>This study is the first to prospectively investigate sleep and postnatal mania risk in a cohort including both high- and low-risk individuals. By integrating actigraphy with validated self-report measures, it aims to identify rest-activity patterns that may serve as early indicators of PP. Early recognition of sleep disturbances associated with postnatal mania could inform targeted interventions, improving clinical outcomes for women and families affected by PP.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"569"},"PeriodicalIF":3.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repetitive negative thinking is associated with cognitive function decline in older adults: a cross-sectional study.","authors":"Niansi Ye, Ling Peng, Bei Deng, Hui Hu, Yuncui Wang, Taoyun Zheng, Yating Ai, Xueting Liu, Shi Zhou, Yucan Li","doi":"10.1186/s12888-025-06815-2","DOIUrl":"10.1186/s12888-025-06815-2","url":null,"abstract":"<p><strong>Background: </strong>Psychological problems such as depression and anxiety increase the risk of cognitive impairment in older adults. But mechanisms on the effect of psychological disorder on cognitive function is inconclusive. Repetitive negative thinking (RNT) is a core symptom of a number of common psychological disorders and may be a modifiable process shared by many psychological risk factors that contribute to the development of cognitive impairment. RNT may increase the risk of cognitive impairment. However, there are fewer studies related to RNT and cognitive function, and there is a lack of epidemiological studies to explore the relationship between RNT and cognitive function.</p><p><strong>Methods: </strong>A cross-sectional study of 424 older adults aged 60 years or over was performed form May to November 2023 in hospital. To investigate the RNT level by using the Perseverative Thinking Questionnaire (PTQ), and investigate the cognitive function level by using the Montreal Cognitive Assessment Scale (MoCA). Multivariable linear regression and subgroup analyses were used to explore the relationship between RNT and cognitive function.</p><p><strong>Results: </strong>We categorized the total RNT scores into quartiles. The multivariable linear regression analysis showed that after adjusting for all covariates, the participants in the Q3 and Q4 groups exhibited lower cognition scores (Q3:β = -0.180, 95%CI -2.849~-0.860; Q4:β = -0.164, 95% -2.611~-0.666) compared to the Q1 group. The results of the subgroup analyses showed that individuals aged 60 ~ 79 years, junior high school and above are more prone to suffer from cognitive impairment with a high RNT score.</p><p><strong>Conclusion: </strong>The study reveals a negative association between RNT and cognitive function in community-dwelling older adults. However, multi-center and a longer time span cohort studies on the relationship between RNT and cognitive function should be carried out to further explore the mechanisms involved.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"562"},"PeriodicalIF":3.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma metabolic profiles in alcohol use disorder: diagnostic role of arginine and emotional implications of N6-acetyl-lysine and succinic acid.","authors":"Guoxin Cao, Bingqing Chen, Yu Sun, Jiansheng Qiao, Tianhao Liu, Jiawei Hou, Xiaojiao Han, Ying Tang, Yixin Fu, Jiang-Hong Ye, Qingfeng Shen, Rao Fu","doi":"10.1186/s12888-025-07014-9","DOIUrl":"10.1186/s12888-025-07014-9","url":null,"abstract":"<p><strong>Background: </strong>Alcohol Use Disorder (AUD) poses a significant global health burden, yet its metabolic underpinnings remain poorly understood. The negative affective states that emerge during withdrawal drive relapse to alcohol-seeking behavior, highlighting the need for precise diagnostic criteria.</p><p><strong>Methods: </strong>This exploratory study utilized targeted plasma metabolomics combined with bioinformatics, machine learning, and correlation analysis to identify biomarkers associated with AUD. Plasma samples from 20 AUD patients and 19 healthy controls were analyzed by liquid chromatography-mass spectrometry targeted metabolomics. The depression and anxiety symptoms severity of the participants were assessed using the Patient Health Questionnaire-9 and Hamilton Anxiety Scale, respectively. Orthogonal partial least squares discriminant analysis model and decision tree machine learning model were used to distinguish metabolites specifically associated with AUD. The Pearson correlation method was employed to investigate the relationship between metabolite concentrations and negative affective symptoms severity in AUD group.</p><p><strong>Results: </strong>178 differential metabolites across 17 super-classes, with amino acids, peptides, and analogues being the most prevalent. Notably, the cAMP signaling pathway emerged as the most strongly associated with AUD, and machine learning identified arginine as a key metabolite. Importantly, N6-acetyl-lysine showed a strong positive correlation with depression severity, while succinic acid was inversely associated with anxiety levels, suggesting that mitochondrial dysfunction and impaired energy metabolism may underlie negative affect in AUD.</p><p><strong>Conclusions: </strong>This study provides new insights into metabolic changes in AUD and demonstrates the potential of metabolomic information as diagnostic biomarkers for AUD and treatment targeting.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"563"},"PeriodicalIF":3.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyberbullying victimization and suicidal ideation among college students: the mediating role of psychological pain and the moderating role of school bonding.","authors":"Xiufang Liu, Xiaowen Liu","doi":"10.1186/s12888-025-07007-8","DOIUrl":"10.1186/s12888-025-07007-8","url":null,"abstract":"<p><strong>Background: </strong>Cyberbullying victimization (CV) among college students has become an increasing serious issue in recent years, raising widespread concern. CV can result in a series of negative consequences in college students, at worst, leading to suicide. Therefore, it is crucial to better understand the mechanisms underlying the link between CV and suicidal ideation (SI). The aim of this study was to explore the mediating role of psychological pain (PP) between CV and SI, as well as the moderating role of school bonding (SB) in this mediation.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted among a sample of 1,247 Chinese college students aged 17 to 25 years (M = 19.98, SD = 1.57; 41.38% male, 58.62% female) in Guizhou Province. The survey utilized validated questionnaires, including the European Cyberbullying Intervention Project Questionnaire, the Positive and Negative Suicidal Ideation Scale, the Psychache Scale, and the School Connectedness Scale. SPSS 25.0 was used for the descriptive statistics and correlation analysis, and the mediated model was tested.</p><p><strong>Results: </strong>CV was directly related to SI, with PP playing a partial mediating role in this relationship. SB was found to moderate both first and second halves of the mediating pathway.</p><p><strong>Conclusion: </strong>PP plays a mediating role between CV and SI. SB moderates the indirect effects of CV on SI. These findings shed light on a potential mechanism of the relationship between CV and SI. Furthermore, they suggest that laws and regulations should be developed or improved by the relevant government departments to provide legal means for preventing college student CV. Additionally, colleges and families should pay attention to the psychological needs of college students and be proactive about alleviating their PP. Finally, colleges and universities should provide support and programming to help college students establish a solid SB.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"564"},"PeriodicalIF":3.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction effect of comorbid depression and proactive positivity coping strategy on the 1-year survival of patients with advanced cancer: a nationwide multicentre study in South Korea.","authors":"Ju Youn Jung, Je-Yeon Yun, Jung Hun Kang, Su-Jin Koh, Yu Jung Kim, Seyoung Seo, Jung Hoon Kim, JaeKyung Cheon, Eun Joo Kang, Eun-Kee Song, Eun Mi Nam, Ho-Suk Oh, Hye Jin Choi, Jung Hye Kwon, Woo-Kyun Bae, Jung Eun Lee, Kyung Hae Jung, EunKyo Kang, Young Ho Yun","doi":"10.1186/s12888-025-06972-4","DOIUrl":"10.1186/s12888-025-06972-4","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Comorbid depression and poor performance status are associated with increased mortality and reduced quality of life in patients with advanced cancer. Coping strategies based on \"proactive positivity\" may facilitate adaptation to functional decline and limited life expectancy. However, few studies have examined the impact of the interaction between depressive symptoms and coping strategies on survival outcomes in this population. This study investigated the associations of 1-year survival with the interaction between comorbid depression and proactive coping strategies, and performance status, in patients with advanced cancer.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This was a secondary analysis of data from a multicentre randomized clinical trial of patients with advanced cancer (ClinicalTrials.gov Identifier: NCT03181854). A total of 144 patients who were aware of their cancer diagnosis were recruited from 12 tertiary hospitals across South Korea between October 2017 and October 2018. In this prospective cohort design, participants were stratified into subgroups with higher versus lower levels of baseline proactive coping (proactive positivity) and followed for 1 year to assess survival status. Demographic and socioeconomic data were collected via self-report questionnaires, while cancer diagnosis and treatment information was obtained from attending oncologists. Cancer-related physical functioning, depressive symptoms, and coping strategies were assessed at baseline and at 12 weeks using the Eastern Cooperative Oncology Group Performance Status (ECOG-PS) scale, the Patient Health Questionnaire-9 (PHQ-9), and the Smart Management Strategy for Health Assessment Tool- short form (SAT-SF), respectively. Univariate Cox regression analyses were conducted to identify factors associated with 1-year survival, and a multivariate Cox proportional hazards model was developed to evaluate the predictive impact of performance status, depression, and the interaction between depression and proactive positivity.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In univariate Cox regression models, lower performance status (ECOG-PS = 2; hazard ratio [HR] = 2.33, 95% confidence interval [CI]: 1.25-4.34) and comorbid depression (PHQ-9 ≥ 10; HR = 2.76, 95% CI: 1.72-4.42) were associated with increased risk of not surviving for 1 year. In the multivariate model, among patients with lower proactive positivity (SAT-SF Core strategies score ≤ 66.66/100), comorbid depression was associated with a 363% higher risk of 1-year mortality compared to those without depression (adjusted HR = 4.63, 95% CI: 2.54-8.43). Conversely, the association between depression and 1-year survival was not statistically significant among patients with higher proactive positivity (SAT-SF score &gt; 66.66/100).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Comorbid depression is associated with a significantly higher risk of 1-year mortality in patients with advanced cancer who exhibit lower levels of pr","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"565"},"PeriodicalIF":3.4,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12131379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}