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Determinants of compulsory admission in detainees with acute psychiatric symptoms in the French speaking counties of Switzerland.
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2025-02-13 DOI: 10.1186/s12888-025-06543-7
Isabella D'Orta, François R Herrmann, Panteleimon Giannakopoulos
{"title":"Determinants of compulsory admission in detainees with acute psychiatric symptoms in the French speaking counties of Switzerland.","authors":"Isabella D'Orta, François R Herrmann, Panteleimon Giannakopoulos","doi":"10.1186/s12888-025-06543-7","DOIUrl":"10.1186/s12888-025-06543-7","url":null,"abstract":"<p><p>Compulsory admission (CA) refers to the process of hospitalization of an individual to a psychiatric ward or hospital, without their consent, due to severe mental health conditions. While it is an established and legally framed practice in many countries, it raises a number of ethical issues in terms of personal liberty and risks of potential misuse. Ethnicity, male gender and psychosis are the main risk factors for compulsory admission to psychiatric wards/hospitals in general population. Previous studies documented that CA is even more frequently used in prison, yet its determinants are still unknown. To address this issue, we explored the clinical, demographic and criminological determinants of compulsory admission in 317 detainees admitted to a psychiatric acute care secure ward located in the central prison of Geneva. We distinguished three groups: voluntary admissions only (VA), CA only and mixed admissions (MA). Judicial status and types of offenses were also recorded. Sociodemographic data included age, gender, and origin. Clinical parameters included previous compulsory admissions, previous hospital stays, number of admissions, length of stay, number of suicide attempts, short-term seclusions and ICD-10 clinical diagnoses. Fisher's exact, Chi<sup>2</sup> and Kruskal Wallis tests were used for group comparisons. Logistic regression analysis was used to explore the association between the legal status of hospital stays and clinical diagnosis. There was no significant difference between the three groups in respect to sociodemographic factors. Past compulsory admissions were significantly more frequent in the CA compared to the VA group. Both the mean number of admissions and length of stay differed significantly between the three groups. The number of suicidal attempts was significantly higher in MA compared to both VA and CA groups. Short-term seclusion was significantly more frequent in CA and MA compared to VA. Psychotic disorders were much more frequent in CA (55.1%) and MA (54.8%) compared to VA cases (23.9%). In contrast, depressive and anxiety disorders were significantly less frequent in CA (12.3%) and MA (14.3%) than VA (29.5%). Of importance, neither the type of offenses nor the judicial status differed between the three groups. In regression models, CA was strongly and positively associated with psychotic disorders. The inverse was true for depressive, anxiety as well as adjustment disorders. The present findings reveal that, in contrast to the general population, sociodemographic factors have no impact on the frequency of CA in a population of detainees. The main risk factors for the adoption of this measure are past CA and presence of acute psychosis. In contrast, the presence of depressive and anxiety symptoms limits the recourse to this disputed measure.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"121"},"PeriodicalIF":3.4,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Major psychiatric comorbidity among the critically ill: a multi-centred cohort study in Queensland.
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2025-02-12 DOI: 10.1186/s12888-025-06520-0
Dylan Flaws, Kyle White, Felicity Edwards, Stuart Baker, Siva Senthuran, Mahesh Ramanan, Antony G Attokaran, Aashish Kumar, James McCullough, Kiran Shekar, Philippa McIlroy, Alexis Tabah, Stephen Luke, Peter Garrett, Kevin B Laupland
{"title":"Major psychiatric comorbidity among the critically ill: a multi-centred cohort study in Queensland.","authors":"Dylan Flaws, Kyle White, Felicity Edwards, Stuart Baker, Siva Senthuran, Mahesh Ramanan, Antony G Attokaran, Aashish Kumar, James McCullough, Kiran Shekar, Philippa McIlroy, Alexis Tabah, Stephen Luke, Peter Garrett, Kevin B Laupland","doi":"10.1186/s12888-025-06520-0","DOIUrl":"10.1186/s12888-025-06520-0","url":null,"abstract":"<p><strong>Background: </strong>Although comorbid medical diseases are important determinants of outcome among the critically ill, the role of psychiatric comorbidity is not well defined. The objective of this study was to determine the occurrence of psychiatric comorbidity and its effect on the outcome of patients admitted to adult intensive care units (ICU) in Queensland.</p><p><strong>Methods: </strong>Admissions among adults to 12 ICUs in Queensland during 2015-2021 were included and clinical and outcome information was obtained through linkages between the ANZICS Adult Patient Database, the state-wide Queensland Hospital Admitted Patient Data Collection, and death registry.</p><p><strong>Results: </strong>A total of 89,123 admissions were included among 74,513 individuals. Overall, 7,178 (8.1%) admissions had psychiatric co-morbidity with 6,270 (7.0%) having one major psychiatric diagnosis and 908 (1%) having two or more. Individual diagnoses of mood, psychotic, anxiety, or affective disorders were present in 1,801 (2.0%), 874 (1.0%), 3,241 (3.6%) and 354 (0.4%) admissions respectively. Significant differences were observed among the main groups (mood, affective, anxiety, psychotic, or multiple disorders) and those without psychiatric comorbidity with respect to main diagnosis, Acute Physiology and Chronic Health Evaluation (APACHE II) score, sex, age, and medical comorbidity. Crude 30-day case-fatality rates were significantly lower (5.1%) compared to the general ICU population (10.1%) (p < 0.001). After controlling for confounding variables in the logistic regression model, patients with psychiatric comorbidity were at lower odds of death.</p><p><strong>Conclusions: </strong>Psychiatric comorbidity is common among ICU presentations and is associated with a lower risk of death. This association is likely to be more complex than being a simple protective factor, and future research needs to further delineate how psychiatric comorbidity informs outcomes of specific ICU presentations.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"118"},"PeriodicalIF":3.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11816750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association between adaptability and the symptoms of depression and anxiety in early adolescents: a network analysis in a longitudinal design.
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2025-02-12 DOI: 10.1186/s12888-025-06559-z
Gangyuan Lu, Linfei Zhu, Rongqian Huang, Pengcheng Lai, Chao Wang
{"title":"The association between adaptability and the symptoms of depression and anxiety in early adolescents: a network analysis in a longitudinal design.","authors":"Gangyuan Lu, Linfei Zhu, Rongqian Huang, Pengcheng Lai, Chao Wang","doi":"10.1186/s12888-025-06559-z","DOIUrl":"10.1186/s12888-025-06559-z","url":null,"abstract":"<p><strong>Background: </strong>The co-occurrence of depression and anxiety is relatively more common among adolescents. Emerging evidence suggests that adaptability might affect this phenomenon. Network analysis can provide insight into the dynamics between symptoms of mental disorders. Therefore, we used network analysis 1) to explore symptom networks and 2) to investigate the association between adaptability and symptoms based on a longitudinal design.</p><p><strong>Methods: </strong>833 Chinese adolescents (449 males and 384 female) were recruited, with adaptability, depressive and anxiety symptoms measured at T1, 426 of them were followed up one year later at T2. Symptom networks were constructed for all participants and for the two groups based on their adaptability scores at T1. Furthermore, mediation analysis was performed to examine the relationship between adaptability and bridge symptoms at both timepoints.</p><p><strong>Results: </strong>Irritable and Guilty showed the highest expected value at T1 (p < 0.05). The high adaptability group's symptom network (HGN) was less connected than the low adaptability group's symptom network (LGN) (p < 0.001). Furthermore, Irritable (T1) and adaptability (T2) were sequential mediators (p < 0.001) between adaptability (T1) and Irritable (T2).</p><p><strong>Conclusions: </strong>These findings suggest that adaptability might affect the network dynamics, underscoring its importance to the occurrence of depression and anxiety among adolescents. Irritable and Guilty being the bridge symptoms may indicate the interventions to target in adolescents with comorbid depression and anxiety.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"117"},"PeriodicalIF":3.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11817081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stress management through cognitive reconstruction and positive thinking in women with recurrent failed In Vitro Fertilization: a randomized controlled trial.
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2025-02-12 DOI: 10.1186/s12888-025-06533-9
Seyedeh Zahra Masoumi, Sara Abdoli, Farideh Kazemi, Shamim Pilehvari, Mohammad Ahmadpanah, Batul Khodakarami, Faezeh Fazli
{"title":"Stress management through cognitive reconstruction and positive thinking in women with recurrent failed In Vitro Fertilization: a randomized controlled trial.","authors":"Seyedeh Zahra Masoumi, Sara Abdoli, Farideh Kazemi, Shamim Pilehvari, Mohammad Ahmadpanah, Batul Khodakarami, Faezeh Fazli","doi":"10.1186/s12888-025-06533-9","DOIUrl":"10.1186/s12888-025-06533-9","url":null,"abstract":"<p><strong>Background: </strong>Individuals undergoing fertility treatments often experience heightened stress levels compared to the general population. With the increasing number of women facing recurrent failed in vitro fertilization (IVF) cycles, this research aimed to assess the effectiveness of positive thinking counseling and cognitive reconstruction in reducing perceived stress among infertile women.</p><p><strong>Methods: </strong>A randomized controlled clinical trial was conducted with 57 women who had undergone unsuccessful IVF cycles at the Fatemiyeh Infertility Center in Hamadan, Western Iran. Using block randomization, participants were randomly assigned to the control group (29 participants)and the intervention group (28 participants). The intervention group received individual face-to-face positive thinking counseling and cognitive reconstruction in eight sessions, each lasting 45 to 60 min. Stress levels were measured using the Cohen Perceived Stress Scale at the beginning of the study and on the embryo transfer day for both groups. Data were analyzed using Stata-13, with a significance levelof p < 0.05.</p><p><strong>Results: </strong>Both groups' mean perceived stress scores showed no statistically significant differences before the intervention (p = 0.168). However, after the intervention, the mean perceived stress scores in the intervention group were significantly lower than those in the control group (p < 0.001).</p><p><strong>Conclusions: </strong>It appears that the use of these counseling approaches leads to a reduction in perceived stress among infertile women.</p><p><strong>Trial registration: </strong>Registration Number: IRCT20120215009014N474, registered on May15, 2023.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"119"},"PeriodicalIF":3.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11823176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful aging was negatively associated with depression and anxiety symptoms among adults aged 65 years and older in Ningbo, China.
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2025-02-11 DOI: 10.1186/s12888-025-06566-0
Lian Li, Hongying Yang, Yan Gao, Wei Yan, Yuerong Yuan, Guomin Lian
{"title":"Successful aging was negatively associated with depression and anxiety symptoms among adults aged 65 years and older in Ningbo, China.","authors":"Lian Li, Hongying Yang, Yan Gao, Wei Yan, Yuerong Yuan, Guomin Lian","doi":"10.1186/s12888-025-06566-0","DOIUrl":"10.1186/s12888-025-06566-0","url":null,"abstract":"<p><strong>Background: </strong>Depression and anxiety are the emotional problems most frequently experienced by older adults. We aimed to investigate the associations between successful aging (SA) and depression and anxiety in older adults from Ningbo, China.</p><p><strong>Methods: </strong>A cross-sectional study of 6,672 community-dwelling adults aged 65 years or older was performed. SA, depression, and anxiety symptoms were self-reported and measured using the Successful Aging Inventory (SAI), Patient Health Questionnaire-9 item (PHQ-9), and the 7-item Generalized Anxiety Disorder scale (GAD-7), respectively. Linear and logistic regression analyses were used to estimate the associations of SA with depression and anxiety.</p><p><strong>Results: </strong>After multivariate adjustment, we found that the SAI score was independently associated with the PHQ-9 and GAD-7 scores (β = -0.069 and - 0.048, respectively). Multivariate-adjusted spline regression models showed negative, nonlinear dose-response associations between the SAI score and both depression and anxiety symptoms (P<sub>for nonlinearity</sub> = 0.001 for both). With the highest quartile set as the reference, we determined that the lowest SAI score quartile was independently associated with both depression symptoms (OR = 16.131, 95% CI: 8.423, 30.892) and anxiety symptoms (odds ratio [OR] = 10.926, 95% confidence interval [CI]: 5.268, 22.664). In subgroup analyses, the association between the SAI score and depression symptoms was significantly higher in rural than in urban areas (P<sub>for interaction</sub> = 0.024).</p><p><strong>Conclusion: </strong>Among older adults in Ningbo, China, SA was found to play an important role in depression and anxiety symptoms, suggesting the need for effective and feasible interventions to promote SA in Chinese older adults.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"115"},"PeriodicalIF":3.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11817734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychiatric disorders and following risk of chronic kidney disease: a prospective cohort study from UK Biobank.
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2025-02-11 DOI: 10.1186/s12888-024-06461-0
Hanfei Li, Chunyang Li, Chao Zhang, Zhiye Ying, Chuanfang Wu, Xiaoxi Zeng, Jinku Bao
{"title":"Psychiatric disorders and following risk of chronic kidney disease: a prospective cohort study from UK Biobank.","authors":"Hanfei Li, Chunyang Li, Chao Zhang, Zhiye Ying, Chuanfang Wu, Xiaoxi Zeng, Jinku Bao","doi":"10.1186/s12888-024-06461-0","DOIUrl":"10.1186/s12888-024-06461-0","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Psychiatric disorders have been reported to influence many health outcomes, but evidence about their impact on chronic kidney disease (CKD) has not been fully explored, as well as possible mechanisms implicated are still unclear.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Four hundred forty-one thousand eight hundred ninety-three participants from UK Biobank were included in this study. To assess the association between psychiatric disorders mainly including depression, anxiety, stress-related disorders, substance misuse as well as psychotic disorder, and CKD, a Cox regression model using age as the underlying time scale was employed. This approach considers the age progression of participants from the beginning to the end of the study as the elapsed time. Flexible nonparametric smoothing model was conducted to illustrate the temporal patterns. Subgroup analyses were performed by stratification of gender, genetic susceptibility to CKD, age at entry or exit the cohort, follow-up duration, and the number of psychiatric disorders at baseline. Mediation analysis was implemented to evaluate the roles of body mass index (BMI), hypertension, and diabetes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Compared with individuals without psychiatric disorders, an increased risk of CKD was observed in patients with psychiatric disorders (hazard ratios (HR) = 1.52, 95% confidence intervals (CI): 1.40-1.65, p-value &lt; 0.001). The hazard ratio among psychiatric patients gradually increased, and became significant after about 10 years follow-ups. The HR for patients followed up for 10-12 years was 1.60 (95% CI: 1.34-1.91, p-value &lt; 0.001), and the HR was 1.66 (95% CI: 1.29-2.13, p-value &lt; 0.001) for patients followed up for 12-13 years. Five distinct psychiatric disorders were found to be significantly associated with an increased risk of developing CKD. The highest HR was observed between stress-related disorder and CKD (HR = 1.95, 95%CI: 1.28-2.97, p-value = 0.002). When adjusting genetic susceptibility to CKD, the HR for the association between stress-related disorders and CKD became 1.86 (95%CI: 1.14-3.04, p-value = 0.013). Although these associations were nominally significant, they did not reach statistical significance after applying the Bonferroni multiple corrections, potentially due to the limited sample size. Subgroup analysis revealed that psychiatric patients who are under age 60, with multiple psychiatric morbidities or having been diagnosed with psychiatric disorders for over 10 years may be high-risk populations. Hypertension, BMI and diabetes mediated 49.13% (95% CI: 37.60%-67.08%), 12.11% (95% CI: 8.49%-17.24%) and 3.78% (95% CI: 1.58%-6.52%) of the total effect, respectively.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Psychiatric disorders were associated with a delayed onset of an elevated risk for CKD, this association was only observed in patients with psychiatric disorders for more than 10 years. Our study highlights the significance of lif","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"109"},"PeriodicalIF":3.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11816523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Social capital and major depressive disorder among youth in Iran.
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2025-02-11 DOI: 10.1186/s12888-025-06545-5
Ebtesam Savari, Nastaran Nasirpour, Afarin Rahimi-Movaghar, Ahmad Hajebi, Vandad Sharifi, Masoumeh Amin-Esmaeili, Farid Najafi, Bahareh Fakhraei, Hamid Hakimi, Mehran Zarghami, Abbas Motevalian
{"title":"Social capital and major depressive disorder among youth in Iran.","authors":"Ebtesam Savari, Nastaran Nasirpour, Afarin Rahimi-Movaghar, Ahmad Hajebi, Vandad Sharifi, Masoumeh Amin-Esmaeili, Farid Najafi, Bahareh Fakhraei, Hamid Hakimi, Mehran Zarghami, Abbas Motevalian","doi":"10.1186/s12888-025-06545-5","DOIUrl":"10.1186/s12888-025-06545-5","url":null,"abstract":"<p><strong>Background: </strong>Social capital has long been recognized as a determinant of various health outcomes. However, the existence and magnitude of these associations may vary across different health conditions, different communities, and periods. This study aimed to investigate the association between social capital and major depressive disorder (MDD) among participants of the Persian Youth Cohort (PYC) study.</p><p><strong>Methods: </strong>The PYC study enrolled 11,592 participants aged 15-34 years, from four cities in Iran representing a range of geographic areas. Baseline assessments included measuring lifetime MDD using the Persian version of the Composite International Diagnostic Interview (CIDI-2.1) and a 27-item social capital questionnaire to evaluate voluntary participation, trust, and sense of cohesion. We analyzed the baseline data using logistic regression to identify potential associations.</p><p><strong>Results: </strong>The prevalence of lifetime MDD was 18.3%. The mean social capital-total score was 73.93 (SD = 13.93). A higher social capital-total score was inversely associated with the likelihood of MDD (AOR: 0.70, 95% CI: 0.66-0.74). Moreover, participants with higher scores in voluntary participation (AOR: 0.88, 95% CI: 0.83-0.92), trust (AOR: 0.65, 95% CI: 0.62-0.68), and sense of cohesion (AOR: 0.72, 95% CI: 0.68-0.75) were less probable to suffer from MDD.</p><p><strong>Conclusion: </strong>Our study corroborates the existing evidence of the association between MDD and the three dimensions of social capital- participation, trust, and sense of cohesion- highlighting the consistency of these findings across diverse settings including young adults in Iran. The use of a valid diagnostic tool for assessing MDD adds robustness to our results, offering valuable insights for regions with similar social and cultural contexts. These findings suggest that interventions fostering social capital, particularly trust and cohesion, may help reduce the burden of MDD in youth.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"111"},"PeriodicalIF":3.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11818031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A randomized controlled trial of a therapist-guided online intervention for depressed adults and its utility as an adjunctive to antidepressants and psychotherapy. 针对抑郁成人的治疗师指导在线干预及其作为抗抑郁药物和心理疗法辅助手段的随机对照试验。
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2025-02-11 DOI: 10.1186/s12888-025-06564-2
Manuel Heinrich, Pavle Zagorscak, Christina Kampisiou, Johannes Bohn, Lars Schulze, Carmen Schaeuffele, Annette Brose, Christine Knaevelsrud
{"title":"A randomized controlled trial of a therapist-guided online intervention for depressed adults and its utility as an adjunctive to antidepressants and psychotherapy.","authors":"Manuel Heinrich, Pavle Zagorscak, Christina Kampisiou, Johannes Bohn, Lars Schulze, Carmen Schaeuffele, Annette Brose, Christine Knaevelsrud","doi":"10.1186/s12888-025-06564-2","DOIUrl":"10.1186/s12888-025-06564-2","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Internet-based interventions (IBIs) are a low-threshold treatment for individuals with depression. However, comparisons of IBI against unstandardized care-as-usual (CAU) are scarce. Moreover, little evidence is available if IBI has an add-on effect for individuals already receiving an evidence-based treatment such as antidepressants and/or psychotherapy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Method: &lt;/strong&gt;This parallel, two-arm RCT (1:1 allocation ratio, simple randomization) examines the effectiveness of a therapist-guided cognitive-behavioral IBI compared to unstandardized CAU in a self-selected sample of adults (≥ 18 years). Eligible individuals reported (a) mild (BDI-II score ≥ 14) to moderately severe (PHQ-9 ≤ 19) symptoms of depression, (b) no acute suicidal ideations, (c) no acute or lifetime (hypo-)mania and/or symptoms of psychosis. We assigned eligible individuals to an intervention (INT) arm or an unstandardized CAU-arm (i.e., we imposed no restrictions on what individuals were allowed to do in the 8-week waiting period). Individuals in the INT-arm got access to a 7-module CBT-based IBI. The primary endpoint is depressive symptom load 9 to 11 weeks after randomization. Secondary endpoints included anxiety, self-efficacy, and perceived social support. We report effects for the entire sample (N = 1899), as well as for individuals using the IBI as a stand-alone intervention (n = 1408) or as an add-on to antidepressants (n = 367), psychotherapy (n = 73), or antidepressants and psychotherapy (n = 51). Patients entered the trial with these concurrent treatments (i.e., they were not randomly assigned).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Concerning all randomized individuals, 62.5% of individuals in the INT-arm accessed all treatment modules within 11 weeks. Individuals assigned to the INT-arm reported significantly lower depressive symptoms (PHQ-9: - 2.5, 95% CI [- 2.9, - 2.0], d =  - 0.7; BDI-II: - 5.3, 95% CI [- 6.5, - 4.1], d =  - 0.8) and higher rates of  ≥ 50% symptom improvements (PHQ-9: 38.5% vs. 14.3%; BDI-II: 44.6% vs. 14.8%) compared to individuals assigned to the CAU-arm. Secondary outcomes also favored INT over CAU, with effect sizes ranging from |d|= 0.18 (social support) to 0.62 (anxiety). Rates of deterioration (PHQ-9: 4.1%; BDI-II: 3.4%) and self-reported side effects (10.5%) were low in the INT-arm. Similar patterns emerged for all strata. However, the between-arm differences failed to reach significance within the strata of individuals using the IBI as an add-on to psychotherapy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Our results show that providing interested adults access to the therapist-guided, cognitive-behavioral IBI under investigation is associated with improved mental health outcomes, whether individuals use the IBI as a stand-alone or add-on intervention to another evidence-based treatment. This finding aligns with available studies indicating that IBIs should be considered a low-threshold treatment option for ","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"116"},"PeriodicalIF":3.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11817706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative effectiveness of short-term psychodynamic psychotherapy and cognitive behavioral therapy for major depression in psychiatric outpatient clinics: a randomized controlled trial.
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2025-02-11 DOI: 10.1186/s12888-025-06544-6
Anders Malkomsen, Theresa Wilberg, Bente Bull-Hansen, Toril Dammen, Julie Horgen Evensen, Benjamin Hummelen, André Løvgren, Kåre Osnes, Randi Ulberg, Jan Ivar Røssberg
{"title":"Comparative effectiveness of short-term psychodynamic psychotherapy and cognitive behavioral therapy for major depression in psychiatric outpatient clinics: a randomized controlled trial.","authors":"Anders Malkomsen, Theresa Wilberg, Bente Bull-Hansen, Toril Dammen, Julie Horgen Evensen, Benjamin Hummelen, André Løvgren, Kåre Osnes, Randi Ulberg, Jan Ivar Røssberg","doi":"10.1186/s12888-025-06544-6","DOIUrl":"10.1186/s12888-025-06544-6","url":null,"abstract":"<p><strong>Background: </strong>More studies with low risk of bias on the effectiveness of cognitive behavioral therapy (CBT) and short-term psychodynamic psychotherapy (STPP) for major depressive disorder (MDD) are needed. This study compares the outcome of CBT and STPP and examines the improvements in each treatment, focusing on effect sizes, reliable change, dropout rates, and remission rates, using broad inclusion criteria (e.g. participants using antidepressants or with strong suicidal ideation).</p><p><strong>Methods: </strong>One hundred patients were randomly allocated to CBT or STPP. All patients were offered either 16 weekly sessions followed by 3 monthly booster sessions in CBT, or 28 weekly sessions in STPP. Primary outcome measures were Hamilton Depression Rating Scale (HDRS) and Beck's Depression Inventory-II (BDI-II). Secondary outcome measures were Work and Social Adjustment Scale (WSAS), Generalized Anxiety Disorder-7 (GAD-7), Global Assessment of Functioning (GAF) and Short Form Health Survey-12 (SF-12).</p><p><strong>Results: </strong>No significant differences in outcomes were found between the two treatment groups on any of the measures. The within-group effects were large (> 0.8) for the primary outcome measures and moderate to large for the secondary outcome measures. According to the reliable change index (RCI), 79% of patients reliably improved on HDRS and 76% improved on BDI-II, whereas respectively 6% and 10% reliably deteriorated.</p><p><strong>Conclusions: </strong>These findings support the assumption that CBT and STPP are equally effective treatments for patients with depressive disorders in psychiatric outpatient clinics. Additionally, they strengthen the evidence for the effectiveness of both CBT and STPP in these settings, while also highlighting that not all depressed patients respond to short-term treatment.</p><p><strong>Clinical trial registration: </strong>Clinical Trial gov. Identifier: NCT03022071. Date of registration: 2016-11-14.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"113"},"PeriodicalIF":3.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11817821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Translation and psychometric properties of the Persian version of the mental health quality of life (MHQoL) questionnaire.
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2025-02-11 DOI: 10.1186/s12888-025-06522-y
Abbas Ebadi, Milad Rezaiye
{"title":"Translation and psychometric properties of the Persian version of the mental health quality of life (MHQoL) questionnaire.","authors":"Abbas Ebadi, Milad Rezaiye","doi":"10.1186/s12888-025-06522-y","DOIUrl":"10.1186/s12888-025-06522-y","url":null,"abstract":"<p><strong>Background: </strong>Patients with psychiatric disorders often experience a reduced quality of life. To accurately assess their well-being, reliable and culturally appropriate tools are essential. The Mental Health Quality of Life (MHQoL) questionnaire, which has seven questions, is designed for this purpose. This study aimed to translate and evaluate the psychometric properties of the MHQoL tool among patients with psychiatric disorders at the psychiatric department of Baqiyatallah Hospital.</p><p><strong>Methods: </strong>This study employed a methodological approach with a descriptive cross-sectional design. After obtaining written permission from the original developer and following the World Health Organization protocol, the Persian version of the questionnaire was administered to 300 psychiatric patients hospitalized in a psychiatric ward in Tehran from October 2022 to March 2023. Of the participants, 39% were female and 61% were male. The questionnaire's face validity, content validity, and construct validity were subsequently evaluated. To determine reliability, Cronbach's alpha coefficient and test-retest methods were used.</p><p><strong>Results: </strong>Through exploratory factor analysis (N = 150) and confirmatory factor analysis (N = 150), one factor was extracted that explained 59.45% of the total observed variance. The model exhibited a good fit, with a GFI of 0.90, CFI of 0.97, IFI of 0.97, NFI of 0.95, PNFI of 0.64, RMSEA of 0.14, CMIN/DF of 3.5, and RMR of 0.049. The Persian version of the MHQoL tool demonstrated high reliability, with a Cronbach's alpha of 0.876 and an intraclass correlation coefficient of 0.979.</p><p><strong>Conclusions: </strong>The current study's findings suggest that the Persian version of the MHQoL is valid and reliable for assessing the quality of life in Persian patients with psychiatric disorders.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"110"},"PeriodicalIF":3.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11817383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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