BMC Psychiatry最新文献

{"title":"Impact of combined art-based intervention on functional connectivity of multiple brain networks in older adults along the cognitive continuum: result from a parallel randomised controlled trial.","authors":"Yuan-Jiao Yan, Rong Lin, Yu-Ting Luo, Chen-Shan Huang, Wen-Chao Cai, Jia-Wei Su, Sheng-Mei Lin, Mo-Jun Lin, Hong Li","doi":"10.1186/s12888-025-06741-3","DOIUrl":"https://doi.org/10.1186/s12888-025-06741-3","url":null,"abstract":"<p><strong>Background: </strong>Combined art-based interventions (CAIs) are considered effective treatment options for older adults along the cognitive continuum; however, the neural mechanisms underlying associated changes in neurocognitive performance remain unclear. Thus, we aimed to investigate the impact of a CAI programme in older adults along the cognitive continuum and to understand its mechanism.</p><p><strong>Methods: </strong>This parallel-arm randomised controlled trial was conducted between April 2021 and January 2023. Participants were randomised in a 1:1 ratio to either intervention group (IG) or waitlist control group (WG). The IG underwent a 16-week CAI programme. Neuropsychological assessments and magnetic resonance imaging were conducted before and after the intervention.</p><p><strong>Results: </strong>After the intervention, the IG showed greater improvement in general cognitive function, language, and memory than the WG. Significant differences were observed in the functional connectivity (FC) values in the temporal and cerebellar anterior lobes, fusiform, inferior occipital, and lingual gyri, and perirhinal and visual cortices between the groups. Further analyses showed that FC values were reduced in these regions in the IG. In addition, changes in FC values were positively correlated with those in neuropsychological test scores in the IG.</p><p><strong>Conclusions: </strong>Our study suggests that the CAI programme can effectively improve general cognitive function, language, and memory in older adults along the cognitive continuum. These improvements may be changed due to decreases in FC in key brain regions, deepening the understanding of the neurocentral mechanisms that act as a tool for improving cognitive function.</p><p><strong>Trial registration: </strong>This trial was registered at ChiCTR.org. Identifier: ChiCTR2100044959, 03/04/2021.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"307"},"PeriodicalIF":3.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormalities in cognitive-related functional connectivity can be used to identify patients with schizophrenia and individuals in clinical high-risk.","authors":"Yangpan Ou, Zhaobin Chen, Ying Wang, Huabing Li, Feng Liu, Ping Li, Dongsheng Lv, Yong Liu, Bing Lang, Jingping Zhao, Wenbin Guo","doi":"10.1186/s12888-025-06747-x","DOIUrl":"10.1186/s12888-025-06747-x","url":null,"abstract":"<p><strong>Background: </strong>Clinical high-risk (CHR) refers to prodromal phase before schizophrenia onset, characterized by attenuated psychotic symptoms and functional decline. They exhibit similar but milder cognitive impairments, brain abnormalities and eye movement change compared with first-episode schizophrenia (FSZ). These alterations may increase vulnerability to transitioning to the disease. This study explores cognitive-related functional connectivity (FC) and eye movement abnormalities to examine differences in the progression of schizophrenia.</p><p><strong>Methods: </strong>Thirty drug-naive FSZ, 28 CHR, and 30 healthy controls (HCs) were recruited to undergo resting-state functional magnetic resonance imaging (rs-fMRI). Connectome-based predictive modeling (CPM) was employed to extract cognitive-related brain regions, which were then selected as seeds to form FC networks. Support vector machine (SVM) was used to distinguish FSZ from CHR. Smooth pursuit eye-tracking tasks were conducted to assess eye movement features.</p><p><strong>Results: </strong>FSZ displayed decreased cognitive-related FC between right posterior cingulate cortex and right superior frontal gyrus compared with HCs and between right amygdala and left inferior parietal gyrus (IPG) compared with CHR. SVM analysis indicated a combination of BACS-SC and CFT-A scores, and FC between right amygdala and left IPG could serve as a potential biomarker for distinguishing FSZ from CHR with high sensitivity. FSZ also exhibited a wide range of eye movement abnormalities compared with HCs, which were associated with alterations in cognitive-related FC.</p><p><strong>Conclusions: </strong>FSZ and CHR exhibited different patterns of cognitive-related FC and eye movement alteration. Our findings illustrate potential neuroimaging and cognitive markers for early identification of psychosis that could help in the intervention of schizophrenia in high-risk groups.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"308"},"PeriodicalIF":3.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The depression-heart connection: cardiovascular risks in cancer patients from NHANES 2005-2018.","authors":"Zheling Chen, Xiuxiu Qiu, Hao Chi, Jingfeng Rong","doi":"10.1186/s12888-025-06727-1","DOIUrl":"https://doi.org/10.1186/s12888-025-06727-1","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have proved that depression is an independent risk factor of cardiovascular disease (CVD) in the general population. We conducted this analysis to explore whether depression symptoms are associated with an increased risk of developing CVD among cancer patients in the United States.</p><p><strong>Methods: </strong>The data for this study were obtained from the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2018, with a total of 1890 cancer patients included in the analysis. A stratified multistage probability sampling design was used to select a nationally representative sample, ensuring demographic groups were proportionally represented. Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9), and CVD risk was determined based on clinical and self-reported data. A weighted multivariate logistic regression analysis was conducted to assess the relationship between depression and CVD risk, adjusting for confounding factors. Subgroup analyses were performed to explore the associations across demographic subgroups.</p><p><strong>Results: </strong>After adjusting for all covariates in the fully adjusted model (Model 3), CVD risk showed a significant association with depression severity. For each unit increase in PHQ-9 score, the adjusted odds ratio (AOR) for CVD was 1.09 (95% CI: 1.05-1.14, P < 0.001). Participants with severe depression exhibited markedly higher odds of CVD compared to those without depression (AOR=6.82,95%CI: 2.39-19.50, P < 0.001). Trend analysis revealed a graded relationship, with CVD risk increasing progressively across depression severity categories (P for trend < 0.001). Restricted cubic spline analysis confirmed a linear dose-response relationship (P for nonlinearity = 0.424), indicating that CVD risk escalates continuously with worsening depression severity.</p><p><strong>Conclusion: </strong>Our findings suggest that more severe depression is associated with higher CVD incidence in cancer populations. These observations highlight the need to consider depressive symptom monitoring as part of comprehensive care approaches that may help address cardiovascular risks in this vulnerable group.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"302"},"PeriodicalIF":3.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nationwide study of emergency care quality for patients with substance use disorders and dual diagnoses across three distinct patient populations.","authors":"Julie Mackenhauer, Mette Marie Berg, Søren Valgreen Knudsen, Erika F Christensen, Jan Mainz, Søren Paaske Johnsen","doi":"10.1186/s12888-025-06712-8","DOIUrl":"10.1186/s12888-025-06712-8","url":null,"abstract":"<p><strong>Background: </strong>Substance use disorders and mental illness increase morbidity and mortality, particularly among patients with coexisting mental illness and substance use (dual diagnoses). This study evaluated the quality of prehospital care (Emergency Medical Services (EMS)) and emergency care for two time-dependent conditions among patients with mental illness, substance use disorders, and dual diagnoses.</p><p><strong>Methods: </strong>We analysed data from three nationwide Danish registries: 1) Danish Prehospital Registry (2016-2017), 2) Danish Stroke Registry (2010-2018), and 3) Danish Registry of Emergency Surgery (2008-2018), supplemented by national health and social registries. Quality of care was assessed using predefined metrics from the clinical registries. Exposure groups included patients with (a) mental illness, (b) substance use disorders, and (c) dual diagnoses, compared with a reference group without either diagnosis.</p><p><strong>Results: </strong>We identified 492,388 EMS calls, 89,148 admissions with ischemic stroke, and 3,223 emergency surgeries for perforated ulcers. Mental illness, substance use disorders, and dual diagnoses were most prevalent in the EMS cohort (10%, 9%, and 8%, respectively). Compared with reference patients, EMS patients with mental illness, substance use, or dual diagnoses were more likely to make repeat EMS calls within 24 h (RR 1.60 [1.39-1.83], 2.32 [2.02-2.66], and 3.24 [2.89-3.53]) and have unplanned hospital visits within seven days after EMS-release at scene, i.e. patient weas not transported to the hospital (scene release) (RR 1.50 [1.39-1.62], 1.58 [1.45-1.73], and 2.50 [2.31-2.71]). Stroke patients with mental illness, substance use, or dual diagnoses were less likely to receive reperfusion therapy for ischemic stroke (RR 0.80 [0.74-0.86], 0.60 [0.54-0.66], and 0.69 [0.60-0.80]) but had rates of other guideline-based stroke care like the reference group without mental illness or substance abuse. Compared with the reference population, patients with perforated ulcers and mental illness experienced a longer time to surgery, with a delay of 82 min (95% CI: 37-128). Within the first 90 days after surgery, patients were 69 days (IQR [0;83]) alive-and-out-of-hospital; however, patients with mental illness, substance use and dual diagnoses lost a median of 4 days (IQR [-1;9]), 6 days [1;10], and 7 days [0;13], respectively, due to early mortality compared with the reference.</p><p><strong>Conclusions: </strong>Disparities in prehospital and emergency care were identified across three distinct cohorts: a broad EMS population and two time-critical conditions. Patients with mental illness, substance use disorders, and dual diagnoses faced inequities in EMS response, reperfusion therapy, surgical timeliness contributing to poorer short-term outcomes. However, areas of consistent care quality were observed, particularly in guideline-based stroke care.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"311"},"PeriodicalIF":3.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poor performance of PHQ-9 and GAD-7 in screening clinical depression and anxiety among a large sample of Chinese children and adolescents.","authors":"Sifan Wang, Jin Lu, Guiqing Zheng, Yandie He, Shuqing Liu, Yi Xiang, Xinyi Liu, Xiang Wang, Yuanyuan Xiao","doi":"10.1186/s12888-025-06754-y","DOIUrl":"https://doi.org/10.1186/s12888-025-06754-y","url":null,"abstract":"<p><strong>Background: </strong>The Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder scale (GAD-7) are widely used symptom-based instruments for screening depression and anxiety. However, their validation in Chinese children and adolescents remains insufficient. We aim to investigate the performance and optimal cut-offs of PHQ-9 and GAD-7 in Chinese children and adolescents in screening clinical depression and anxiety, and to discuss the influencing factors of the cut-offs.</p><p><strong>Methods: </strong>The study subjects were chosen from 3 sites of the Mental Health Survey for Children and Adolescents in Yunnan (MHSCAY), a total of 2,237 participants who had been screened positive by self-administered questionnaire and further diagnosed by using the gold standard were included in the final analysis. The Receiver Operating Characteristic (ROC) curves were used to determine the discriminative ability of the two instruments, measured by using the area under curve (AUC). The optimal cut-offs of the two instruments were determined by the maximum Youden's index. A series of stratified analyses were performed to discover the best cut-offs for children and adolescents of different characteristics. Logistic regression models were adopted to evaluate the influence of self-harm (SH) on identified optimal cut-offs.</p><p><strong>Results: </strong>We found the performance was generally poor for both the PHQ-9 and GAD-7 in screening clinical depression and anxiety in our study sample, with the AUCs ranged only between 0.622-0.712. When using the two instruments for diagnosis purpose, 11 was the optimal cut-off for both clinical depression and anxiety (AUC for PHQ-9: 0.664, AUC for GAD-7: 0.669). For study subjects of different age, gender, race, and left-behind status, discordant cut-offs were identified. SH also showed conspicuous influence on the optimal cut-offs of PHQ-9 and GAD-7, and the combination of SH information can increase screening accuracy of PHQ-9 in some subgroups.</p><p><strong>Conclusions: </strong>Both the PHQ-9 and GAD-7 showed poor performance in screening clinical depression and anxiety in our study sample. This crucial finding suggests that, despite the wide use of the two scales, they might be fundamentally inadequate for depression and anxiety screening in Chinese children and adolescents. Other screening tools of higher accuracy should be developed and used in this age group.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"301"},"PeriodicalIF":3.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Death anxiety and death literacy among Turkish patients with chronic diseases: a cross-sectional study.","authors":"Vahide Semerci Çakmak, Ahmet Seven, Ebru Sönmez Sari","doi":"10.1186/s12888-025-06761-z","DOIUrl":"https://doi.org/10.1186/s12888-025-06761-z","url":null,"abstract":"<p><strong>Background: </strong>Death anxiety is common in patients with chronic diseases. Death literacy is a novel theoretical framework that enables patients to discuss death, accept it as a natural aspect of life, and get a deeper comprehension of it. However, it is unclear whether there is a relationship between death literacy and death anxiety. Furthermore, death literacy has not been sufficiently researched in Turkish society. This study investigated the levels of death anxiety and death literacy among Turkish patients with chronic diseases and the factors affecting death anxiety.</p><p><strong>Methods: </strong>This was a cross-sectional study. The sample consisted of Turkish patients with chronic diseases (n = 225). The data were collected with the Turkish Death Anxiety Scale and the Death Literacy Index. Pearson correlation, independent samples t test, One-Way ANOVA, and multiple linear regression were employed to analyse the data.</p><p><strong>Results: </strong>There exists a negative moderate correlation between death anxiety and death literacy. It has been determined that the factors that most influence patients' fear of death are their level of death literacy and gender. These factors explained 12.8% of the variance in death anxiety (R² = 0.128, F = 3.153, p < 0.001).</p><p><strong>Conclusions: </strong>The results suggest that death literacy level and gender were found to be factors affecting death anxiety of patients. Women have higher death anxiety scores. While the level of death literacy of Turkish patients with chronic diseases increases, their death anxiety decreases. The findings of the study were believed to offer a comprehensive information for healthcare practitioners in the management of such patients.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"299"},"PeriodicalIF":3.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A national survey of suicidality and non-suicidal self-injury in bipolar disorder: insights from network analysis.","authors":"Lvchun Cui, Yuncheng Zhu, Yang Li, Jia Zhou, Guiyun Xu, Miao Pan, Zhiyu Chen, Wenfei Li, Zhian Jiao, Mingli Li, Yong Zhang, Jingxu Chen, Xiuzhe Chen, Na Li, Jing Sun, Jian Zhang, Shaohua Hu, Haishan Wu, Zhaoyu Gan, Yan Qin, Yumei Wang, Yantao Ma, Xiaoping Wang, Xiaohong Li, Chuangxin Wu, Yiyun Cai, Jiaye Chen, Baichuan Wu, Zuowei Wang, Daihui Peng, Yiru Fang","doi":"10.1186/s12888-025-06750-2","DOIUrl":"https://doi.org/10.1186/s12888-025-06750-2","url":null,"abstract":"<p><strong>Background: </strong>There is a high prevalence of suicidal ideation (SI), suicide attempts (SA), and non-suicidal self-injury (NSSI) in bipolar disorder (BD). Understanding the nature of suicidality and NSSI in BD is an important way to inform optimal intervention for reducing suicide risk. We aimed to investigate the prevalence and correlates of SI, SA, and NSSI in patients with BD using data from a national survey. We used network analysis to explore the associations among suicidality, NSSI, addictive features of NSSI, and symptoms of BD.</p><p><strong>Methods: </strong>Participants with BD were recruited from 20 research centers in China. Suicidality, NSSI, addictive features, and symptoms of BD were measured via a standardized electronic case report form. We used logistic regression and network analysis for data analysis.</p><p><strong>Results: </strong>Of the 1,055 participants recruited, over 50% with depressive or mixed episodes had SI, more than 20% engaged in SA, and over 40% reported NSSI. The polarity of mood episodes was independently associated with SI ([hypo]mania vs. mixed episodes: odds ratio [OR] = 0.22, 95% confidence interval [CI] 0.14-0.33, p < 0.001) and NSSI ([hypo]mania vs. mixed episodes: OR = 0.33, 95% CI 0.19-0.58, p < 0.001; depressive episodes vs. mixed episodes: OR = 0.59, 95% CI 0.35-0.98, p = 0.040). Participants with mixed episodes reported the most severe addictive features of NSSI. SI was the most influential symptom within the network model of the total sample; NSSI, SI, and depressive symptoms were identified as key \"bridge symptoms\".</p><p><strong>Conclusions: </strong>Suicidality and NSSI in BD were closely associated with depressive and mixed episodes, with mixed episodes showing the highest prevalence of NSSI and the most pronounced addictive features. SI was identified as the central symptom within the self-harm network, emphasizing its importance as an intervention target. These findings could offer potential insights regarding suicidality and NSSI in BD that can inform intervention strategies.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"297"},"PeriodicalIF":3.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing access to psychological therapy on acute mental health wards: staff and patient experiences of a stepped psychological intervention.","authors":"Isobel Johnston, Dawn Edge, Paul Wilson, Adele Beinaraviciute, Sandra Bucci, Richard Drake, Gill Gilworth, Gillian Haddock, Fritz Handerer, Sonalia Kaur, Karina Lovell, Helen Morley, Owen Price, Mica Samji, Katherine Berry","doi":"10.1186/s12888-025-06721-7","DOIUrl":"https://doi.org/10.1186/s12888-025-06721-7","url":null,"abstract":"<p><strong>Background: </strong>Psychological therapies are recommended for people with serious mental health problems. However, access is limited, particularly in inpatient mental health settings. The Talk, Understand and Listen in InPatient Settings (TULIPS) study is a large multi-centre cluster-randomised controlled trial which aimed to evaluate a stepped psychological intervention model to increase access to therapies for inpatients. This paper presents findings from the embedded process evaluation focusing on the contextual factors influencing intervention delivery.</p><p><strong>Methods: </strong>Thirty-two staff and 31 patients from wards receiving the intervention participated in semi-structured interviews. Data was analysed using reflexive thematic analysis. Staff and patient data were analysed separately but perspectives were compared and interwoven resulting in five themes.</p><p><strong>Results: </strong>Patients reported sessions with psychologists facilitated greater self-understanding and coping. Staff and patients reflected that formulations improved staff understanding of patient presentations. This understanding was associated with improved staff-patient relationships, more person focused practice and reduced conflict and burnout. Psychologists' frequent physical presence on the wards and support of nursing teams enabled staff buy-in. However, significant barriers in resource, skill and confidence inhibited the delivery of nurse-led interventions within the stepped care model, as did perceptions that intervention delivery was outside the remit of nursing staff's role.</p><p><strong>Conclusions: </strong>This study provides evidence that a stepped psychological intervention on acute mental health wards could improve patient coping and ward experience for patients and staff. Future studies should target nursing staff confidence and skill in the delivery of psychological interventions.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT03950388. Registered 15th May 2019. https://clinicaltrials.gov/ct2/show/NCT03950388 .</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"300"},"PeriodicalIF":3.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between childhood trauma and internet addiction in adolescents with depression: the mediating role of insomnia and alexithymia.","authors":"Xixin Wang, Feng Sun, Feng Geng, Changhao Chen, Jiawei Wang, Xiangwang Wen, Xiangfen Luo, Huanzhong Liu","doi":"10.1186/s12888-025-06739-x","DOIUrl":"https://doi.org/10.1186/s12888-025-06739-x","url":null,"abstract":"<p><strong>Background: </strong>The correlation between depressive symptoms and internet addiction in adolescents is strengthened, and childhood trauma is an important predictor of internet addiction. However, the mechanism of childhood trauma on internet addiction in adolescents with depression remains unclear. This study investigates the current status and factors influencing internet addiction in adolescents with depression and further examines whether insomnia and alexithymia mediate childhood trauma and internet addiction in adolescents with depression.</p><p><strong>Methods: </strong>This study investigated 300 adolescent patients in 7 hospitals in Anhui province. General demographic characteristics such as age and gender were collected. The clinical characteristics of the patients were measured using the Childhood Trauma Questionnaire Short Form (CTQ-SF), Internet Addiction Test (IAT), Insomnia Severity Index (ISI) and 20-item Toronto Alexithymia Scale (TAS-20). PROCESS (Model 4) was used to examine the mediating effects of insomnia and alexithymia.</p><p><strong>Results: </strong>The prevalence of internet addiction among adolescents with depression was 50.2%. There were statistically significant differences between the internet addiction group and the non-internet addiction group in terms of relationships with classmates, relationships with teachers, family relations, and economic status. The total score of CTQ and its five subscale scores were significantly and positively correlated with the total score of IAT. Insomnia and externally oriented thinking (EOT) played a significant mediating role in the effect of physical neglect (PN) on internet addiction.</p><p><strong>Conclusion: </strong>Insomnia and alexithymia play a significant mediating role between childhood trauma and internet addiction in adolescents with depression, which expand the existing understanding of internet addiction in adolescents with depression, and provide some theoretical references to address the problem of internet addiction in adolescents with depression and prevent the development of adolescent depression.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"298"},"PeriodicalIF":3.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatrist-led hepatitis C (HCV) treatment at an opioid agonist treatment clinic in Stockholm- a model to enhance the HCV continuum of care.","authors":"Per-Erik Klasa, Mikael Sandell, Soo Aleman, Martin Kåberg","doi":"10.1186/s12888-025-06733-3","DOIUrl":"10.1186/s12888-025-06733-3","url":null,"abstract":"<p><strong>Background: </strong>People with opioid agonist therapy (OAT) represent a population with an increased hepatitis C (HCV) prevalence. Recent studies provide strong evidence regarding effective HCV treatment outcomes and low levels of reinfection in this population. Increased access to HCV care for people with OAT is essential to reach the WHO goal of eliminating HCV as a major public health threat by 2030.</p><p><strong>Methods: </strong>The Maria OAT clinic, located in central Stockholm, provides OAT for approximately 500 patients. The majority have a history of injection drug use. In October 2017, psychiatrist-led HCV treatment was initiated, with remote consultation support from the local infectious diseases clinic. All OAT staff participated in HCV-specific education to increase HCV awareness. To evaluate HCV treatment outcomes for this model of care, we examined sustained virological response (SVR) and reinfection rates between January 2018 and December 2022.</p><p><strong>Results: </strong>Between October 2017 and June 2022, 133 participants received HCV treatment through weekly administrations or directly observed treatment. 72% were men, and the overall mean age was 44.7 years. Six participants were retreated, giving a total of 139 treatment initiations. All were HCV RNA negative at end of treatment, and 88% reached SVR. A total of 11 reinfections post SVR were noted, with a reinfection rate of 7.3/100 person-years (95% CI 4.1-12.9).</p><p><strong>Conclusion: </strong>Overall, successful HCV treatment results and levels of reinfections consistent with the literature were achieved. Bringing HCV diagnostics and treatment to an OAT clinic constitutes a good example of enhancing the HCV continuum of care. Furthermore, HCV treatment education for psychiatrists, addiction specialists and staff at OAT clinics makes HCV care more sustainable, as specifically noted during the COVID-19 pandemic. This successful model of care, introducing HCV treatment by psychiatrists on-site at OAT clinics, has now been further implemented at other OAT clinics in Stockholm.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"291"},"PeriodicalIF":3.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}