BMC Psychiatry最新文献

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Associations between serum uric acid and risk of depressive symptoms in East Asian populations.
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2024-12-18 DOI: 10.1186/s12888-024-06343-5
Menghui Yao, Xinxin Han, Yue Yin, Shuolin Wang, Yingdong Han, He Zhao, Hong Di, Juan Wu, Yun Zhang, Xuejun Zeng
{"title":"Associations between serum uric acid and risk of depressive symptoms in East Asian populations.","authors":"Menghui Yao, Xinxin Han, Yue Yin, Shuolin Wang, Yingdong Han, He Zhao, Hong Di, Juan Wu, Yun Zhang, Xuejun Zeng","doi":"10.1186/s12888-024-06343-5","DOIUrl":"https://doi.org/10.1186/s12888-024-06343-5","url":null,"abstract":"<p><strong>Background: </strong>Despite the fact that observational studies have reported associations between serum uric acid (SUA) and depressive symptoms risk in East Asian populations, there is a lack of evidence demonstrating a causal relationship between them. This study aimed to perform a comprehensive assessment of the relationship between SUA and depressive symptoms.</p><p><strong>Methods: </strong>This study included two cohort studies and a two-sample Mendelian randomization study. The cross-sectional cohort was derived from the China Health and Retirement Longitudinal Study (CHARLS) wave 3 (in 2015), and the baseline data of participants were extracted from the CHARLS wave 1(in 2011), excluding those with depressive symptoms in 2011 and forming a longitudinal cohort from 2011 to 2015. Logistic multiple regression was performed to investigate the cross-sectional and longitudinal associations of SUA with depressive symptoms in the two cohorts. Furthermore, we performed two-sample Mendelian randomization analyses to explore the potential causal relationships between them.</p><p><strong>Results: </strong>We included two cohorts of 9056 and 3177 individuals respectively. Logistic regression showed that individual with higher SUA levels had a lower risk of depressive symptoms (OR = 0.921; 95%CI: 0.886-0.957) in the cross-sectional cohort. However, neither the baseline SUA level (OR = 1.055, 95%CI: 0.961-1.157) nor the change in SUA level (OR = 0.945, 95%CI: 0.656-1.363) affected the depressive symptoms 4 years later in the longitudinal cohort. The two-sample MR showed that there was no genetic causal relationship between SUA and depression (OR<sub>IVW_MRE</sub>= 1.071, 95% CI: 0.926-1.238).</p><p><strong>Conclusions: </strong>SUA and depressive symptoms are associated, with lower SUA levels observed in middle-aged and older participants with depressive symptoms; however, no causal evidence supports their relationship.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"930"},"PeriodicalIF":3.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global burden of Alzheimer's disease and other dementias attributed to metabolic risks from 1990 to 2021: results from the global burden of disease study 2021.
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2024-12-18 DOI: 10.1186/s12888-024-06375-x
Xinyi Zhang, Tongtong Guo, Ya Zhang, Min Jiao, Lihong Ji, Zhiwei Dong, Haiyan Li, Shanquan Chen, Wengui Zheng, Qi Jing
{"title":"Global burden of Alzheimer's disease and other dementias attributed to metabolic risks from 1990 to 2021: results from the global burden of disease study 2021.","authors":"Xinyi Zhang, Tongtong Guo, Ya Zhang, Min Jiao, Lihong Ji, Zhiwei Dong, Haiyan Li, Shanquan Chen, Wengui Zheng, Qi Jing","doi":"10.1186/s12888-024-06375-x","DOIUrl":"https://doi.org/10.1186/s12888-024-06375-x","url":null,"abstract":"<p><strong>Objective: </strong>The risk of Alzheimer's disease (AD) and other dementias increases with greater global exposure to metabolic risks, making this a crucial public health issue. This study aimed to report the metabolism-attributable global burden of AD and other dementias from 1990 to 2021.</p><p><strong>Methods: </strong>The Global Burden of Disease Study (GBD) 2021 collected data on the number of deaths and disability-adjusted life-years (DALYs) related to AD and other dementias caused by metabolic risks, including high fasting plasma glucose (FPG) and high body mass index (BMI). The analysis assessed the disease burden and temporal patterns worldwide, examining data by region, country, level of social development, age group, and sex.</p><p><strong>Results: </strong>Globally, the count of AD and other dementia-related deaths due to metabolic risks grew from 98,608 to 399,824, a 4.1-fold increase. For dementias related to high FPG and high BMI, the age-standardized mortality rates (ASMR) and age-standardized DALY rate (ASDR) increased with age and were higher in females than in males. In 2021, the highest burden was observed in high-income North America. The ASMR and ASDR have grown worldwide between 1990 and 2021. The burden of metabolism-related AD and other dementias was positively correlated with the Socio-Demographic Index (SDI), with higher ASMR and ASDR in high SDI regions but showing more pronounced increases in low and low-middle SDI regions.</p><p><strong>Conclusions: </strong>Metabolism-related global burden of AD and other dementias is increasing, particularly among women and in high-income regions. Targeted prevention programs for dementia should be developed, along with early interventions for risk factors.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"910"},"PeriodicalIF":3.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Social support and depressive symptoms among migrant elderly following children: the chain mediating role of resilience and loneliness.
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2024-12-18 DOI: 10.1186/s12888-024-06349-z
Haixia Liu, Xiaoyu Chen, Yinggang Yao, Wenqi He, Qi Zhang, Hui Zeng
{"title":"Social support and depressive symptoms among migrant elderly following children: the chain mediating role of resilience and loneliness.","authors":"Haixia Liu, Xiaoyu Chen, Yinggang Yao, Wenqi He, Qi Zhang, Hui Zeng","doi":"10.1186/s12888-024-06349-z","DOIUrl":"https://doi.org/10.1186/s12888-024-06349-z","url":null,"abstract":"<p><strong>Background: </strong>Migrant elderly following children (MEFC) is an emerging special elderly mobile migrant population in China. MEFC face multiple dilemmas of distress, which makes their depressive symptoms more prominent. To explore ways to alleviate depressive symptoms, this study aimed to investigate the chain mediating effects of resilience and loneliness on the relationship between social support and depressive symptoms among MEFC.</p><p><strong>Methods: </strong>A cross-sectional study was conducted using purposive sampling from Changsha, Hunan Province, China, and 298 MEFC were included. The 15-item Geriatric Depression Scale, Social Support Rating Scale, University of California Los Angeles Loneliness Scale, and Connor-Davidson Resilience Scale were used to measure depressive symptoms, social support, loneliness, and resilience, respectively. Pearson's correlation analysis was conducted to clarify the association between the variables. The PROCESS macro model 6 was applied to analyze the multiple mediating effects.</p><p><strong>Results: </strong>The prevalence of depressive symptoms among MEFC was 29.86%. Social support (r = -0.354, P < 0.001), resilience (r = -0.373, P < 0.001), and loneliness (r = 0.483, P < 0.001) were significantly associated with depressive symptoms. Social support not only had a direct negative effect (Effect= -0.086, 95% CI: -0.149 to -0.023) on depressive symptoms, but also had an indirect effect on depressive symptoms through resilience (Effect= -0.045, 95% CI: -0.076 to -0.015), loneliness (Effect= -0.053, 95% CI: -0.091 to -0.020), and the chain mediating effects of resilience and loneliness (Effect= -0.019, 95% CI: -0.037 to -0.007), respectively.</p><p><strong>Conclusions: </strong>The prevalence of depressive symptoms was relatively high. Resilience and loneliness partially mediated the association between social support and depressive symptoms. In the future, interventions could focus on increasing social support to enhance resilience and reduce loneliness, thereby reducing depressive symptoms in MEFC.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"898"},"PeriodicalIF":3.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Collection and sharing of health information in mental health and related systems in Australia: perspectives of people who access mental health services.
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2024-12-18 DOI: 10.1186/s12888-024-06347-1
Anne Honey, Nicola Hancock, Helen Glover, Justin Newton Scanlan, Yidan Cao, Andrew Povolny, Mark Orr, Grenville Rose, Sumathi Govindasamy, Lorraine Smith, Naseem Ahmadapour
{"title":"Collection and sharing of health information in mental health and related systems in Australia: perspectives of people who access mental health services.","authors":"Anne Honey, Nicola Hancock, Helen Glover, Justin Newton Scanlan, Yidan Cao, Andrew Povolny, Mark Orr, Grenville Rose, Sumathi Govindasamy, Lorraine Smith, Naseem Ahmadapour","doi":"10.1186/s12888-024-06347-1","DOIUrl":"https://doi.org/10.1186/s12888-024-06347-1","url":null,"abstract":"<p><strong>Background: </strong>Information sharing and information privacy are important issues in mental health services. Yet the perspectives of Australians who access mental health services about these issues are poorly understood. This article addresses the research question: What are the concerns of people who use mental health services about the collection and use of their health information in mental health and related systems in Australia?</p><p><strong>Methods: </strong>Participants were 16 people who had accessed mental health services and were involved in a series of co-design workshops as part of a larger study. Focused group activities were conducted in which participants were asked to discuss and create a visual map to describe their collective experiences of sharing information relating to mental health and recovery. The data were analysed using qualitative content analysis and the coding techniques of constant comparative analysis.</p><p><strong>Results: </strong>Participants expressed a sense of unknowability about the information held and accessed by various organisations. They described providing information to a wide variety of entities, though not always in a free or informed way. They believed other information held about them had been generated and/or shared by people other than themselves, often without their knowledge or consent. Participants reported that both the collection and storage of this information involved risks for them, and they sometimes restricted the information they provided. To improve their comfort with the use of their information, participants recommended customised and transparent information collection; individuals' access and input to their own information; and use of information only for their benefit.</p><p><strong>Conclusions: </strong>Trust is key to positive experiences of information provision and information sharing. Central to establishing trust are transparent practices that facilitate greater choice and control.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"932"},"PeriodicalIF":3.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of childhood trauma on sustained attention in major depressive disorder: the mediating role of brain activity and functional connectivity.
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2024-12-18 DOI: 10.1186/s12888-024-06385-9
Mingfeng Lai, Ping Jiang, Peiwei Xu, Dan Luo, Wenxin Bao, Jing Li, Jiajun Xu
{"title":"Effects of childhood trauma on sustained attention in major depressive disorder: the mediating role of brain activity and functional connectivity.","authors":"Mingfeng Lai, Ping Jiang, Peiwei Xu, Dan Luo, Wenxin Bao, Jing Li, Jiajun Xu","doi":"10.1186/s12888-024-06385-9","DOIUrl":"https://doi.org/10.1186/s12888-024-06385-9","url":null,"abstract":"<p><strong>Background: </strong>Sustained attention deficits were reported more significant in patients with major depressive disorder (MDD) than in healthy controls (HCs), and are pivotal in both the development and aggravation of depression. Childhood trauma is also common in MDD and the exposure to childhood trauma may impede sustained attention and increase the treatment resistance in MDD. However, the underlying neuro-mechanisms link the childhood trauma to sustained attention deficits in MDD remain unclear.</p><p><strong>Methods: </strong>We collected resting-state functional magnetic resonance imaging data, and measured childhood trauma severity using the Childhood Trauma Questionnaire and sustained attention using the Continuous Performance Test, Identical Pairs version. After excluding subjects with significant head movement, 45 MDDs and 54 HCs were included in the analysis. We compared fractional amplitude of low-frequency fluctuation (fALFF) between the groups, conducted whole-brain correlation analysis between the fALFF and sustained attention in the MDD group, and defined significant regions as the regions of interest for the seed-to-whole brain functional connectivity (FC) analysis. We further performed mediation analyses to investigate the relationships among the childhood trauma, fALFF and FC values, and the level of sustained attention in the MDD group.</p><p><strong>Results: </strong>Compared with HCs, MDDs exhibited higher fALFF in the right middle frontal gyrus and left inferior frontal gyrus, and lower fALFF in the bilateral insular cortex, left medial orbital superior frontal gyrus and left angular gyrus (ANG.L). Whole-brain correlation analysis showed that impaired sustained attention was associated with increased fALFF in the left postcentral gyrus (PoCG.L), and FC of PoCG.L-left precentral gyrus (PreCG.L) and ANG.L-right superior temporal gyrus (STG.R) in the MDD group. Furthermore, mediation analyses showed that the fALFF in PoCG.L, and FC of PoCG.L-PreCG.L and ANG.L-STG.R mediated the relationship between the childhood trauma and sustained attention in the MDD group.</p><p><strong>Conclusion: </strong>The fALFF in PoCG.L, and FC of PoCG.L-PreCG.L and ANG.L-STG.R might be potential neural substrate in the association between the childhood trauma and poor sustained attention in the MDDs, and might serve as potential intervention targets for the treatment of sustained attention deficits in MDDs with childhood trauma history.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"918"},"PeriodicalIF":3.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Are we genuinely going to have our voices heard?" The experience of co-producing a blended intervention to prevent relapse in obsessive-compulsive disorder: a qualitative study on the perspectives of experts by lived experience.
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2024-12-18 DOI: 10.1186/s12888-024-06355-1
Josie F A Millar, Nina Higson-Sweeney, Tom A Jenkins, Erin F Waites, Sophie Minns
{"title":"\"Are we genuinely going to have our voices heard?\" The experience of co-producing a blended intervention to prevent relapse in obsessive-compulsive disorder: a qualitative study on the perspectives of experts by lived experience.","authors":"Josie F A Millar, Nina Higson-Sweeney, Tom A Jenkins, Erin F Waites, Sophie Minns","doi":"10.1186/s12888-024-06355-1","DOIUrl":"https://doi.org/10.1186/s12888-024-06355-1","url":null,"abstract":"<p><strong>Introduction: </strong>Co-production involves researchers, practitioners and people with lived experience working in a collaborative manner, with shared power. The potential benefits of co-production are well documented. However, there is little research describing the experience of having been involved in co-production from the perspective of Experts By Lived Experience (EBLE). The aim of the present study is to explore the experiences of EBLE of obsessive-compulsive disorder (OCD) on their involvement in co-producing a blended intervention to prevent relapse for OCD.</p><p><strong>Methods: </strong>Five EBLE took part in semi-structured interviews enquiring about their experiences of co-producing a relapse prevention intervention. Reflexive thematic analysis was used to analyse the data.</p><p><strong>Results: </strong>Four themes were developed: (1) Welcome but unexpected therapeutic benefits; (2) The parameters of a safe space; (3) Genuine co-production brings meaningful change; and (4) Navigating the challenging terrain of co-production.</p><p><strong>Conclusions: </strong>Overall, EBLE reported their involvement in the co-production process to have had positive impacts on both the development of the intervention and their own personal recovery journey. EBLE valued the safety created within the group, and the importance this had for allowing them to speak open and honestly about their experiences and the difficulties that can arise with the nature of the work.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"906"},"PeriodicalIF":3.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aberrant amplitude of low-frequency fluctuation and functional connectivity in children with different subtypes of ADHD: a resting-state fNIRS study.
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2024-12-18 DOI: 10.1186/s12888-024-06350-6
Qinwei Liu, Wenjing Liao, Li Yang, Longfei Cao, Ningning Liu, Yongxue Gu, Shaohua Wang, Xiaobin Xu, Huafen Wang
{"title":"Aberrant amplitude of low-frequency fluctuation and functional connectivity in children with different subtypes of ADHD: a resting-state fNIRS study.","authors":"Qinwei Liu, Wenjing Liao, Li Yang, Longfei Cao, Ningning Liu, Yongxue Gu, Shaohua Wang, Xiaobin Xu, Huafen Wang","doi":"10.1186/s12888-024-06350-6","DOIUrl":"https://doi.org/10.1186/s12888-024-06350-6","url":null,"abstract":"<p><strong>Background: </strong>Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with different subtypes of pathogenesis. Insufficient research on the subtypes of ADHD has limited the effectiveness of therapeutic methods.</p><p><strong>Methods: </strong>This study used resting-state functional near-infrared spectroscopy (fNIRS) to record hemodynamic signals in 34 children with ADHD-combined subtype (ADHD-C), 52 children with ADHD-inattentive subtype (ADHD-I), and 24 healthy controls (HCs). The amplitude of low-frequency fluctuation (ALFF) and the functional connectivity (FC) analysis were conducted for all subjects.</p><p><strong>Results: </strong>Compared with HCs, the ADHD group exhibited significantly increased ALFF and decreased FC. The ADHD-C group showed significantly higher ALFF in partial brain regions and significantly lower FC between multiple brain regions than participants with ADHD-I. The male group displayed a significant increase in ALFF in some brain regions, while no significant difference was found in FC when compared to the female group.</p><p><strong>Conclusions: </strong>This study provides evidence to support the subtype classification of ADHD-I and ADHD-C, and the combined analysis of ALFF and FC has the potential to be a promising biomarker for the diagnosis of ADHD.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"919"},"PeriodicalIF":3.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Behavioral problems in children with unoperated rheumatic heart disease at national referral hospital in Ethiopia: an observational study.
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2024-12-18 DOI: 10.1186/s12888-024-06401-y
Addishiwot Melesse, Rediet Fasil, Dejuma Yadeta, Henok Tadele
{"title":"Behavioral problems in children with unoperated rheumatic heart disease at national referral hospital in Ethiopia: an observational study.","authors":"Addishiwot Melesse, Rediet Fasil, Dejuma Yadeta, Henok Tadele","doi":"10.1186/s12888-024-06401-y","DOIUrl":"https://doi.org/10.1186/s12888-024-06401-y","url":null,"abstract":"<p><strong>Background: </strong>The behavioral disorder is characterized by a profound abnormality in an individual's cognition, emotion or behavior that reflects in psychological, biological or developmental dysfunction. Rheumatic heart disease (RHD) is a long-term sequel of single or recurrent acute rheumatic fever. Children with RHD are thought to be at increased risk for behavioral problems due to autoimmunity seen in pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). Behavior disorder is not well studied among children with RHD. Hence, this study aimed to assess the pattern and predictors of behavioral problems among children with RHD enrolled in chronic care at a national cardiac referral Hospital.</p><p><strong>Methods: </strong>This cross-sectional study used a validated parental-reported Amharic Strengths and Difficulties Questionnaire (SDQ) to assess behavior problems. Children with RHD aged 6-17 years on chronic outpatient cardiac care at Tikur Anbessa Specialized Hospital, Ethiopia between February and May 2023 were included. Factors associated with behavior problems were assessed using logistic regression models.</p><p><strong>Results: </strong>The study included 166 children with a median age of 15 years [Interquartile range (IQR):13-17 years]. One-fourth of children, 24.7% (95% CI: 18.34-31.98), had behavioral problems. Of these, 46.4% (77) emotional, 35.5% (59) peer, 18.1% (30) conduct and 6.6% (11) hyperactivity problems were documented. Children who had good medication adherence, adjusted odds ratio AOR 0.29(95% CI: 0.09-0.94, P 0.040) and on New York Health Association (NYHA) class I, AOR 0.28(95% CI: 0.11-0.79, P 0.016) had lower odds for behavioral problems.</p><p><strong>Conclusion: </strong>One-fourth of children with RHD had behavioral abnormalities. Medication adherence and NYHA predicted behavioral abnormality. Better physical symptom control was associated with fewer behavioral problems. Behavioral abnormalities should be considered and assessed among children with RHD. Further multi-center mixed studies are recommended to uncover the unseen behavioral problem and guide health policy action on modalities of integration of behavioral problems assessment tools in clinical care.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"913"},"PeriodicalIF":3.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emotional processing as mechanism of change in brief good psychiatric management for borderline personality disorder: results of a randomized controlled trial.
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2024-12-18 DOI: 10.1186/s12888-024-06370-2
Ueli Kramer, Loris Grandjean, José Blanco Machinea, Hélène Beuchat, Setareh Ranjbar, Yves de Roten, Jean-Nicolas Despland, Philippe Conus, Stéphane Kolly
{"title":"Emotional processing as mechanism of change in brief good psychiatric management for borderline personality disorder: results of a randomized controlled trial.","authors":"Ueli Kramer, Loris Grandjean, José Blanco Machinea, Hélène Beuchat, Setareh Ranjbar, Yves de Roten, Jean-Nicolas Despland, Philippe Conus, Stéphane Kolly","doi":"10.1186/s12888-024-06370-2","DOIUrl":"https://doi.org/10.1186/s12888-024-06370-2","url":null,"abstract":"<p><strong>Background: </strong>Borderline Personality Disorder (BPD) is one of the most frequent, severe, mental conditions and is associated with a serious burden of disease. Treatment for patients with BPD involves structured psychotherapy. In addition and in order to improve access to care, psychiatric treatments are available. So far, it remains unclear if brief psychiatric intervention according to Good Psychiatric Management (GPM) produces a reliable effect on a variety of clinical outcomes. The assessment of mechanisms of change contributes to focus the treatment on the essential ingredients of change. The current study aims to demonstrate the emotional processing as a mechanism of change, assessed in an ecologically valid experimental context, of brief GPM.</p><p><strong>Methods: </strong>The present two-arm randomized controlled study aims at testing the effects (i.e., reduction in borderline symptoms) and emotional processing as mechanism of change of a brief psychiatric treatment (10 sessions over 4 months), compared with treatment as usual. Participants are N = 76 patients with BPD who are either randomized to a 4 month GPM or a 4 month TAU without any BPD-specific content. All patients undergo assessments of borderline symptoms using ZAN-BPD and experiential enactment for assessment of emotional processing, at intake, 2 months and 4 months (discharge).</p><p><strong>Results: </strong>The effect of a brief version of GPM is not different from the effect of TAU on the total score of the ZAN-BPD at 4 month (d = 0.04). At the level of the secondary effects, GPM is more effective in reducing relationship problems on the ZAN-BPD sub-scale (F(1, 61) = 5.53; p = .022, d = 0.52), and in reducing impulsivity and social problems, and it increases treatment retention. Change in emotional processing between intake and month 2 mediates the reduction on the ZAN-BPD subscale relationship problems assessed between months 2 and 4, in an ecologically valid experimental context.</p><p><strong>Conclusions: </strong>Overall, brief GPM is not different from TAU in terms of reduction in borderline symptoms, but it may produce reduction in relationship problems between months 2 and 4 into the brief intervention. Change in emotional processing in an experimental context may function as mechanism of change of brief GPM. This study is in line with the top priority of establishing efficacy of brief interventions for BPD and proposes an evidence-based explanation for efficacy. These results should help disseminate brief psychiatric treatments for BPD, which contribute to reduce the societal burden related with BPD.</p><p><strong>Trial registration: </strong>Clinical Trials NCT03717818 (date of registration of Abstract October 24th, 2018). Protocol number 2 from February 9th, 2018.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"921"},"PeriodicalIF":3.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics of positive and negative effects on the quality of life of breast cancer patients.
IF 3.4 2区 医学
BMC Psychiatry Pub Date : 2024-12-18 DOI: 10.1186/s12888-024-06311-z
Jin Zhao, De-Shuang Yang, Yi-Qi Liu, Yan-Kun Wu, Chao Chen, Ji-Tao Li, Ren-Gang Wu
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