BMC Psychiatry最新文献

{"title":"Blue light treatment of psychiatric disorders: relationships with systemic inflammation, lipid metabolism, and clinical symptoms.","authors":"Lina Ren","doi":"10.1186/s12888-025-07247-8","DOIUrl":"https://doi.org/10.1186/s12888-025-07247-8","url":null,"abstract":"<p><strong>Background: </strong>Psychiatric disorders impose a substantial burden on individuals and society, and current treatment exhibit limited efficacy. Emerging evidence indicates that blue light exposure can influence mood and psychiatric conditions, yet its underlying mechanisms are not fully understood. Since that systemic inflammation is regarded as an important factor in mental health, this study explores the potential relationships between blue light therapy, immune-related pathways, and psychiatric symptoms.</p><p><strong>Method: </strong>In this single-center retrospective study, medical records from 270 hospitalized psychiatric patients were analyzed. Patients received either routine treatment alone or in combination with blue light therapy, and were further stratified by season, treatment duration, and primary diagnosis.</p><p><strong>Results: </strong>Blue light therapy was related to significant changes in key inflammation markers and psychiatric symptoms. Notably, we observed seasonal variations in the relationship between immune markers and specific psychiatric symptoms following blue light therapy.</p><p><strong>Conclusion: </strong>Blue light therapy may offer a promising adjunctive approach for psychiatric disorders potentially through its associations with systemic inflammation and related symptoms. More studies are needed to explore its pathology and potential applications in clinical settings.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"1008"},"PeriodicalIF":3.4,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal relationship between anxiety and sleep quality in community residents: the mediating effect of loneliness.","authors":"Wenyu Wang, Zhen Wei, Meiqi Wang, Yazhuo Qi, Long Sun","doi":"10.1186/s12888-025-07474-z","DOIUrl":"https://doi.org/10.1186/s12888-025-07474-z","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"1004"},"PeriodicalIF":3.4,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Arabic version of the 16-item free and cued recall test among patients with schizophrenia.","authors":"Najla Sam, Chadia Haddad, Benjamin Calvet, Oussama Dahdouh","doi":"10.1186/s12888-025-07417-8","DOIUrl":"https://doi.org/10.1186/s12888-025-07417-8","url":null,"abstract":"<p><strong>Background: </strong>Several subjective scales have been used to measure verbal memory in patients with schizophrenia, such as the 16-item free and cued recall test. This study aimed to validate the Arabic version of the 16 item free and cued recall test among patients with schizophrenia.</p><p><strong>Methods: </strong>A cross-sectional study was performed among 172 patients with schizophrenia and 60 healthy controls at the Psychiatric Hospital of the Cross, Lebanon. The 16 item free and cued recall test was used to assess verbal memory in patients with schizophrenia.</p><p><strong>Results: </strong>The internal consistency of the Free and Cued Recall test was 0.722, and the factor analysis revealed a 2-factor solution accounting for 79.35% of the variance. A significant difference between schizophrenia patients and healthy controls was found across all recall items, except for cued recall 3 and delayed cued recall, with patients scoring lower overall. Additionally, the test positively correlated with BACS verbal memory (r = 0.352, p < 0.001) and working memory (r = 0.421, p < 0.001), as well as the MOCA test (r = 0.474, p < 0.001). Test-retest reliability indicated moderate stability, with Pearson correlations ranging from 0.33 to 0.79 and intraclass correlation coefficients (ICCs) between 0.46 and 0.59.</p><p><strong>Conclusion: </strong>The Free and Cued Recall test exhibited satisfactory psychometric properties, including adequate internal consistency, good construct validity, and strong concurrent validity.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"1006"},"PeriodicalIF":3.4,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variation in the recall of socially rewarding information and symptoms of generalised anxiety: evidence from two cohorts.","authors":"Chi Ling Yeung, Peiyao Tang, Gemma Lewis, Glyn Lewis, Nicola Wiles, Jessica K Bone","doi":"10.1186/s12888-025-07402-1","DOIUrl":"https://doi.org/10.1186/s12888-025-07402-1","url":null,"abstract":"<p><strong>Background: </strong>Cognitive theories suggest that anxiety symptoms are associated with increased recall of threatening information, but previous evidence has been inconsistent. We examined whether recall of socially rewarding or threatening information was associated with concurrent and subsequent generalised anxiety disorder (GAD) symptoms.</p><p><strong>Methods: </strong>We used data from a cohort study (N = 530, 68% female) and the baseline of a randomised controlled trial (N = 653, 58% female). All participants had a history of depressive symptoms. Both studies included a computerised task assessing incidental word recall and measured GAD symptoms using the Generalised Anxiety Disorder Assessment (GAD-7). We tested concurrent associations in both samples and lagged associations in the cohort, which measured GAD scores at four time-points (two weeks apart) and recall at the first three time-points. We used multilevel linear (cohort) and linear (RCT) regression models, before and after adjusting for confounders.</p><p><strong>Results: </strong>In the cohort, there was strong evidence that better recall of socially rewarding information was associated with lower GAD scores concurrently (coef=-0.18; 95% CI=-0.31-0.04). There was no evidence for an association with recall of socially threatening words (coef=-0.04, 95% CI=-0.20-0.12). Longitudinally, there was no evidence that recall of socially rewarding or threatening information was associated with subsequent GAD scores. In the RCT, there was evidence that better recall of socially rewarding information was associated with lower concurrent GAD scores (coef=-0.32; 95% CI=-0.56-0.08).</p><p><strong>Conclusions: </strong>GAD may be characterised by difficulty in recalling socially rewarding information but not memory for socially threatening information. Our findings indicate that recalling less socially rewarding information may be a marker of current GAD symptoms, but not a risk factor longitudinally.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"1009"},"PeriodicalIF":3.4,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between anxiety disorders and medication adherence in patients with cardiovascular disease: a systematic review and meta-analysis of observational studies.","authors":"Tingting Wang, Zhiyong Li, Yunjie Wei, Xiaofei Zhang, Qianjiao Yuan, Xiaohong Zhang, Xuying Li, Qinqin Lei","doi":"10.1186/s12888-025-07350-w","DOIUrl":"https://doi.org/10.1186/s12888-025-07350-w","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"1005"},"PeriodicalIF":3.4,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing resting motor threshold to predict cognitive function in drug-naive patients with major depressive disorder.","authors":"Li Xu, Jing He, Lei Yang, Decai Du, Fan Yang, Limei Feng, Yuxiong Jin, Chao Li, Jianzhong Yang","doi":"10.1186/s12888-025-07393-z","DOIUrl":"10.1186/s12888-025-07393-z","url":null,"abstract":"<p><strong>Background: </strong>Major depressive disorder (MDD) is a common and disabling condition associated with significant cognitive impairments that persist over the long term, affecting patients' social function. Traditional cognitive testing methods are time-consuming and subjective. This study investigates whether resting motor threshold (RMT), a neurophysiological measure of motor cortical excitability, can predict cognitive function in drug-naive patients with MDD, with a focus on sex-specific differences.</p><p><strong>Methods: </strong>This cross-sectional study enrolled 158 first-episode, drug-naive patients with MDD from August 2023 to April 2024. Participants underwent comprehensive cognitive assessments using the MATRICS Consensus Cognitive Battery (MCCB) and transcranial magnetic stimulation (TMS) to measure RMT. Hormone levels were also assessed. The study was approved by the hospital's Ethics Committee and conducted in accordance with the Declaration of Helsinki. Statistical analysis included bivariate correlation and multiple regression analyses to identify factors associated with cognitive function.</p><p><strong>Results: </strong>A total of 138 subjects completed the study. The mean age was 19.28 ± 6.84 years, with 41 males (29.7%) and 97 females (70.3%). In the overall sample, higher right RMT was associated with better attention/vigilance (CPT-IP) performance. In male patients, higher left RMT was associated with lower verbal learning (HVLT-R) scores, while higher right RMT was associated with higher HVLT-R scores. No significant correlations were found in female patients. Multiple regression analyses showed that these relationships were independent of age, education, and hormone levels.</p><p><strong>Conclusions: </strong>This exploratory study is the first to demonstrate that RMT can predict verbal learning ability, attention, and vigilance in male patients with MDD, whereas no significant correlation was observed in female patients. This finding reveals RMT's potential significance and highlights that sex differences necessitate consideration when developing rTMS-based treatment regimens targeting both antidepressant and cognitive outcomes. Further longitudinal studies with larger sample sizes are needed to validate its clinical relevance.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"1001"},"PeriodicalIF":3.4,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12535144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of personal traits on the dignity of individuals living with schizophrenia: a qualitative study.","authors":"Elham Amiri, Rahim Baghaei, Hossein Habibzadeh, Hossein Ebrahimi","doi":"10.1186/s12888-025-07477-w","DOIUrl":"10.1186/s12888-025-07477-w","url":null,"abstract":"<p><strong>Background: </strong>Schizophrenia significantly detrimentally affects the social functioning of individuals afflicted, particularly in the domains of interpersonal relationships, professional engagements, and personal self-care. These patients are viewed as a group facing discrimination across various aspects of social life, where their personal dignity is accorded lower respect, and they encounter challenges in accessing education, property rights, and the fair administration of justice, ultimately resulting in a breach of their dignity. The individual traits of patients play a vital part in safeguarding or compromising their dignity. This topic remains understudied within the sociocultural framework of Iran.</p><p><strong>Methods: </strong>This qualitative study was carried out employing conventional content analysis. The collection of data was accomplished through the utilization of semi-structured and in-depth face-to-face interviews, conducted with 16 patients with schizophrenia (good or partial insight), 4 family caregivers, 2 nurses, 3 psychologists, and 1 service worker. The data were analyzed according to Graneheim and Lundman.</p><p><strong>Results: </strong>The main categories included \"Strategies for Problem-Solving\" (two subcategories: \"Having a cognition-oriented approach\", and \"Having a problem-oriented approach\"), \"Patient's level independence and dependence\" (two subcategories: \"Patient's dependence on others\", and \"Independent\"), \"Patient's behavioral dimensions and expectations\" (two subcategories: \"Respectful behavior\", and \"Having too many expectations\"), and \"Patient's clinical status\" (two subcategories: \"Disease status\", and \"Level of insight\").</p><p><strong>Conclusion: </strong>This research found that the dignity of individuals with schizophrenia is linked to levels of autonomy and empowerment. Patients acknowledged that attempting to take control of their problems enabled them to preserve their dignity to the greatest extent feasible. Patients attempted to cope with the situation by acquiring new skills and enhancing self-empowerment. Therefore, nurses must be aware of how to provide support to patients with schizophrenia. Implementing counseling programs in medical facilities and community-based health clinics for families supporting individuals with schizophrenia is crucial to assist with patient empowerment and rehabilitation, thus enabling patients to reintegrate into society while preserving their dignity.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"1000"},"PeriodicalIF":3.4,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12535009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A large-sample (N = 49,109) network analysis of depressive symptoms in children from single-parent and two-parent families.","authors":"Yujia Liao, Xiangyu Deng, Jie Gong, Yao Peng, Xianyong An, Qianyu Zhang, Xuerong Liu, Xiaobing Tian","doi":"10.1186/s12888-025-07435-6","DOIUrl":"10.1186/s12888-025-07435-6","url":null,"abstract":"<p><strong>Background: </strong>As the number of single-parent families continues to rise, concerns about the mental health of children in these families have grown. Network theory offers a novel approach to understanding and intervening in cases of depression by examining the interconnections among depressive symptoms. This study aims to explore the differences in depressive symptom networks between children from two-parent and single-parent families at the symptom level using network analysis.</p><p><strong>Methods: </strong>This study was conducted from September to October 2022 in Nanchong, Sichuan Province, China. The survey data were collected from 49,109 upper elementary school students as part of a universal screening program. Depressive symptoms were assessed using the Center for Epidemiological Studies Depression Scale (CES-D). Using the NetworkComparisonTest (NCT), the CES-D networks were compared between children from two-parent and single-parent families, as well as between single-father and single-mother families.</p><p><strong>Results: </strong>In the depression symptom networks of children from two-parent and single-parent families, Sad (Strength = 1.10) was the most central symptom in two-parent family networks, whereas Not enjoying life (Strength = 1.20) was the most central symptom in single-parent families. Network connections were denser in single-parent families than in two-parent families (global strength: S = 8.50 vs. 8.11, p = 0.02). Restless sleep had higher strength centrality in single-parent families than in two-parent families (strength difference = 0.12, p._adjust = 0.01). However, global strength and structure did not differ between single-father and single-mother networks.</p><p><strong>Conclusion: </strong>These findings provide deeper insights into the structure of depressive symptoms among children from single-parent families. Targeting central symptoms in interventions may offer new strategies for preventing depression in this population.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"999"},"PeriodicalIF":3.4,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12535102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of suicidal ideation and depression in the general population with subthreshold insomnia using machine learning models.","authors":"Polona Rus Prelog, Teodora Matić, Peter Pregelj, Aleksander Sadikov","doi":"10.1186/s12888-025-07451-6","DOIUrl":"10.1186/s12888-025-07451-6","url":null,"abstract":"<p><strong>Background: </strong>Insomnia is a significant independent risk factor for depression and suicidality. However, these conditions often go undetected, particularly in individuals presenting with sleep complaints. This study aimed to develop and validate machine learning (ML) models for the indirect screening of suicidal ideation (SI) and depression and to specifically evaluate their performance in a population reporting at least subthreshold insomnia.</p><p><strong>Methods: </strong>Data were obtained from a Slovenian nationwide community sample (N = 2,989) via an online questionnaire. Logistic regression models were developed to predict SI (measured by SIDAS) and moderate-to-severe depression (measured by DASS-21) via indirect predictors, including socio-demographics, life satisfaction, behavioral changes, and 14 coping strategies from the Brief COPE inventory. The model performance was tested on a validation sample, which was stratified into groups with (Insomnia Severity Index [ISI] score ≥ 8; n = 917) and without (ISI < 8; n = 819) insomnia symptoms.</p><p><strong>Results: </strong>The models demonstrated strong and consistent predictive performance across both groups. The area under the receiver operating characteristic curve (AUROC) for the SI model was 0.78 in the insomnia group and 0.80 in the non-insomnia group. For the depression model, the AUROCs were 0.79 and 0.82, respectively. The minimal difference in performance indicates that the models are robust and equally effective regardless of the presence of insomnia.</p><p><strong>Conclusion: </strong>Our findings demonstrate that ML models using indirect questions can effectively screen for both suicidality and depression simultaneously. The models' robust performance in individuals with insomnia highlights their potential as feasible, ethical, and efficient tools for early detection. Given that sleep complaints are a common reason for seeking healthcare, this approach offers a critical opportunity for timely intervention in a high-risk population, potentially reducing preventable morbidity and mortality associated with suicide and depression.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"1003"},"PeriodicalIF":3.4,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12535028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meaning in life among Norwegian outpatients with personality disorders: a cross-sectional study.","authors":"Aryan Aghdami, Geir Pedersen, Elfrida Hartveit Kvarstein, Tatjana Schnell","doi":"10.1186/s12888-025-07366-2","DOIUrl":"10.1186/s12888-025-07366-2","url":null,"abstract":"<p><strong>Background: </strong>Meaning in life (MIL) is associated with positive health outcomes, but is generally low among people suffering from borderline personality disorder (PD). Research has shown that MIL has a buffering effect on depression, as well as borderline traits such as suicidality and self-harm. However, to date, no studies have examined Meaning in Life (MIL) in relation to other prevalent personality disorders such as avoidant PD, nor have they investigated how PD severity influences MIL or whether MIL buffers the impact of PDs on psychosocial functioning.</p><p><strong>Methods: </strong>Norwegian outpatients (N = 1708) were assessed for PDs in specialized clinics, and measured for meaning in life, symptoms of depression, anxiety and impairment of psychosocial functioning. The data underwent correlational analyses, then grouped into sub-threshold PD, borderline PD, avoidant PD and dual PD (satisfying criteria for both) and tested for mean differences in MIL. Mean differences in MIL were explored across different levels of psychosocial functioning impairment. Finally, a moderation analysis tested whether MIL would buffer the effect that symptoms of depression had on impairment of psychosocial functioning.</p><p><strong>Results: </strong>As expected, correlational analyses showed a negative relationship between MIL and symptoms of ill mental health. A community sample demonstrated the highest MIL, followed by the sub-threshold PDs, the single PDs (either borderline or avoidant), and the Dual PDs with the lowest MIL. Impairment in psychosocial functioning showed significant differences between each level of impairment (low, moderate, severe), with varying results between the PD-groups across these levels. The moderation analysis only showed a buffering effect for the sub-threshold PDs, and not for any other group who received a diagnosis of PD.</p><p><strong>Conclusion: </strong>Having a PD is associated with a severe detriment to the level of MIL. There is no apparent difference in mean MIL between the two most prevalent types of PDs in healthcare (borderline and avoidant PDs). However, the current findings indicate that severity results in different levels of MIL, thus lending support to the dimensional perspective of personality disorder.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"997"},"PeriodicalIF":3.4,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12532927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}