BMC Psychiatry最新文献

{"title":"Caregiver psychiatric symptoms, assessment delay, and access to supports for children with neurodevelopmental conditions.","authors":"Kelsie A Boulton, Antoinette Hodge, Natalie Ong, Christel M Middeldorp, David Coghill, Natalie Silove, Adam J Guastella","doi":"10.1186/s12888-025-07403-0","DOIUrl":"https://doi.org/10.1186/s12888-025-07403-0","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"1002"},"PeriodicalIF":3.4,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring risky decision-making dynamics during antidepressant treatment in major depressive disorder: a computational modeling approach.","authors":"Weiting Zhou, Zhaoyu Zuo, Xinlei Ji, Qinyu Liu, Fan Xiao, Shulin Fang, Penghui Guo, Qiang Luo, Xiang Wang","doi":"10.1186/s12888-025-07412-z","DOIUrl":"https://doi.org/10.1186/s12888-025-07412-z","url":null,"abstract":"<p><strong>Background: </strong>Patients with major depressive disorder (MDD) show greater loss sensitivity and higher delayed discounting rates during decision making, but findings regarding their risk preferences are inconsistent. Computational behavioral modeling provides a promising tool for the investigation of these latent factors underlying the decision-making behaviors.</p><p><strong>Objectives: </strong>Conduct both cross-sectional and longitudinal analyses to identify patterns and changes in risky decision-making over time, examine correlations between traditional CGT performance indicators and cognitive modeling parameters to better understand the underlying mechanisms of decision-making, and separately explore participants' reward and loss sensitivities.</p><p><strong>Methods: </strong>At baseline, 52 patients with MDD and 66 healthy controls (HCs) underwent psychometric assessment and performed the Cambridge gambling task (CGT) characterizing risky decision-making behavior. After 8 weeks of treatment with the selective serotonin reuptake inhibitor, the patient group underwent assessment and performed the CGT again. Applying a cumulative model to the trial-by-trial behavioral data of the CGT, we also compared the latent factors between groups, including probability distortion, color bias, utility/loss sensitivity, delayed reward discounting and choice consistency.</p><p><strong>Results: </strong>Patients with MDD had more depressive symptoms and anhedonia than did HCs. MDD group exhibited both greater delayed reward discounting and lower choice consistency than HCs. After the treatment, MDD group had both decreased loss sensitivity and color choice bias. Controlling for depressive symptoms, a deficit in consummatory pleasure with motivational drive was associated with greater delayed reward discounting at baseline in MDD group.</p><p><strong>Conclusions: </strong>Our findings suggest that patients with MDD have deficits in reward function (higher delayed reward discounting and lower risk adjustment) at baseline. With antidepressant treatment, loss sensitivity decreased while impairment in reward function persists, and these patients tend to make more risky choices after treatment.</p><p><strong>Trial registration: </strong>The registration number is ChiCTR2000031931 and date of registration is April 15th 2020.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"1016"},"PeriodicalIF":3.4,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health disorders and determinants among adolescents living with HIV: a first national estimation in Togo (The MIND-HIV study), 2025.","authors":"Sonia Kanekatoua, Arnold Junior Sadio, Fifonsi Adjidossi Gbeasor-Komlanvi, Saliou Salifou, Latifou Assikpa, Aboubakar Issa, Zakillatou Adam, Komlan Mawuko Gbetogbe, Damega Wenkourama, Charfoundine Affo, Adjévi Awoussi, Eddy Yehouenou, René Aklesso Kpeguie, Jean Marie Atsou Alley, Vincent Palokinam Pitche, Didier Koumavi Ekouevi, Simliwa Kolou Dassa, Anoumou Claver Dagnra","doi":"10.1186/s12888-025-07488-7","DOIUrl":"https://doi.org/10.1186/s12888-025-07488-7","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"1011"},"PeriodicalIF":3.4,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative stress and cognitive function in Chinese patients with major depressive disorder: the mediating role of depression severity.","authors":"Rui-Jie Peng, Chao Sun, Yu Fan, Jin Li, Ju Gao, Wen-Xi Sun, Xiao-Bin Zhang, Qing Tian","doi":"10.1186/s12888-025-07478-9","DOIUrl":"https://doi.org/10.1186/s12888-025-07478-9","url":null,"abstract":"<p><strong>Background: </strong>Oxidative stress is increasingly implicated in the pathophysiology of major depressive disorder (MDD), which is often accompanied by significant cognitive impairments. However, the interplay between oxidative stress markers, cognitive function, and the severity of depression symptom, particularly the potential mediating role of severity, requires further investigation. This study aimed to examine alterations in oxidative stress markers in Chinese patients with MDD, their association with cognitive performance, and whether depression and anxiety severity mediates this relationship.</p><p><strong>Methods: </strong>Forty-four patients meeting DSM-5 criteria for MDD and 47 matched healthy controls (CON) were recruited. Cognitive functions were assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and the Stroop Color-Word Test. Depression and anxiety severity were evaluated using the Hamilton Depression Rating Scale (HAMD-24) and Hamilton Anxiety Rating Scale (HAMA). Plasma levels of oxidative stress markers, including malondialdehyde (MDA) and catalase (CAT), were measured via ELISA. Group comparisons (controlling for education), correlation analyses, and mediation analyses (using bootstrapping) were performed.</p><p><strong>Results: </strong>Compared to healthy controls, patients with MDD exhibited significantly higher plasma MDA levels (1.9 ± 0.4 vs. 1.6 ± 0.5 nmol/mL, P = 0.025) and lower CAT activity (0.7 ± 0.2 vs. 0.9 ± 0.3 U/mL, P = 0.020). The MDD group showed significant cognitive deficits in immediate memory (P = 0.002), attention (P < 0.001), delayed memory (P = 0.010), and the RBANS total score (P = 0.002). Plasma MDA levels negatively correlated with immediate memory (r = - 0.34, P = 0.033) and delayed memory (r = - 0.36, P = 0.021), and positively correlated with both HAMD (P = 0.041) and HAMA scores (P = 0.048). Mediation analyses revealed that HAMD and HAMA scores significantly mediated the relationship between plasma MDA levels and immediate memory performance (Indirect effect P < 0.05 for both).</p><p><strong>Conclusions: </strong>Chinese patients with MDD demonstrate heightened oxidative stress (elevated MDA, reduced CAT) and impaired cognitive function, particularly in memory domains, compared to healthy individuals. Higher levels of oxidative stress marker MDA are associated with greater depression/anxiety severity and poorer memory performance. Furthermore, symptom severity partially mediates the link between oxidative stress and immediate memory deficits, suggesting a complex interplay among these factors in MDD pathophysiology.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"1012"},"PeriodicalIF":3.4,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behind closed doors: unlocking hospital variations in the use of seclusion and mechanical restraint - a nationwide multilevel analysis in adult mental healthcare in France.","authors":"E Touitou-Burckard, M Coldefy, C Bourin, A Ellini, S Saetta, C Gandré","doi":"10.1186/s12888-025-07404-z","DOIUrl":"https://doi.org/10.1186/s12888-025-07404-z","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"1014"},"PeriodicalIF":3.4,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in event-related potentials between unipolar depression and bipolar II disorder during depressive episodes: a retrospective case-control study.","authors":"Xiaobo Zhou, Jingwen Liu, Zhonghua Lin, Minjing Xiang, Xia Deng, Zhili Zou","doi":"10.1186/s12888-025-07433-8","DOIUrl":"https://doi.org/10.1186/s12888-025-07433-8","url":null,"abstract":"<p><strong>Background: </strong>Bipolar II disorder (BD II) is a chronic and severe mental illness frequently misdiagnosed as major depressive disorder (MDD) due to symptom overlap and the absence of objective diagnostic tools. Consequently, establishing pathophysiological markers to differentiate BD II from MDD is critical.</p><p><strong>Method: </strong>A total of 180 patients were enrolled in the study and allocated to three groups: patients with unipolar depression (UD group; MDD currently experiencing a major depressive episode, n = 60), patients with bipolar II disorder during depressive episodes (BD II group; n = 60), and age- and sex- matched healthy controls (HC; n = 60). Sociodemographic data were collected, and all participants underwent psychological assessments using the 7-item Generalized Anxiety Disorder (GAD-7), Patient Health Questionnaire-9 (PHQ-9), and 32-item Hypomania Checklist (HCL-32). Additionally, all participants passed auditory brain stem response (ABR) test and subsequently underwent event-related potential (ERP) examinations.</p><p><strong>Results: </strong>No significant differences were observed in demographic characteristics between the three groups, including age, sex, educational level, marital status, and socioeconomic status (all P > 0.05). Compared with HC, patients in both the UD and BD II groups showed significantly longer reaction time (HC: 254.4 ± 43.8 ms; UD: 297.7 ± 72.2 ms; BD II: 300.3 ± 70.0 ms; P = 0.028) and larger amplitude of P2-N2 complex (HC: 5.7 ± 4.4 μV; UD: 8.1 ± 4.8 μV; BD II: 8.6 ± 5.6 μV; P = 0.001) in P300 paradigm. The BD II group exhibited longer S2-P50 latency than the UD group (UD: 50.4 ± 11.1 ms vs. BD II: 63.2 ± 11.5 ms; P = 0.025). Additionally, the BD II group had prolonged N2 latency compared to HC (BD II: 216.2 ± 22.1 ms vs. HC: 205.2 ± 16.5 ms; P = 0.044).</p><p><strong>Conclusions: </strong>This study may identify neurophysiological distinctions between BD II and UD depression, notably a prolonged S2-P50 latency in BD II.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"1013"},"PeriodicalIF":3.4,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-utility analysis of screening and cognitive behavioral therapy compared to usual care for postpartum depression.","authors":"Bohan Wang, Shuyuan Shen, Kris Yw Lok, Jingxia Lin, Robert David Smith","doi":"10.1186/s12888-025-07459-y","DOIUrl":"https://doi.org/10.1186/s12888-025-07459-y","url":null,"abstract":"<p><strong>Background: </strong>Postpartum depression is common and leads to an increase in the risk of poorer maternal outcomes and suicide. Implementing effective screening and treatment for postpartum depression is an international public health priority.</p><p><strong>Objective: </strong>This study aims to estimate the cost-effectiveness of implementing a strategy of Whooley screening followed by referral to Cognitive Behavioral Therapy (CBT) for women screened positive compared with the current Treatment as Usual (TAU) for women with postpartum depression in Hong Kong.</p><p><strong>Methods: </strong>A decision tree model was constructed to estimate the potential cost and utility benefits for Whooley screening followed by referral to CBT for women screened positive compared to TAU in Hong Kong. The model used healthcare costs, in Hong Kong Dollars (HKD), and quality-adjusted life years (QALYs) to estimate economic and health utility outcomes. We used two states (no depression/remission, and depression) modeled over the postpartum period. Deterministic, probabilistic sensitivity analyses and scenario analyses were conducted to explore the robustness of the results under the uncertainty around the model input parameters.</p><p><strong>Results: </strong>The base-case analysis suggested that Whooley screening followed by referral to CBT for women screened positive yielded an additional 0.014 QALYs compared to TAU and added HKD3193.15 to the cost per patient. Deterministic sensitivity analysis indicated that cost-effectiveness results were robust to utilities associated with depression, utilities associated with no depression/remission, and the probability of no improvement in depression for CBT. Probabilistic sensitivity analysis showed that Whooley screening followed by referral to CBT for women screened positive had a 100% likelihood of being more cost-effective than TAU at a willingness-to-pay (WTP) threshold of HKD422,191/QALY. Scenario analysis showed the important influence of patients' acceptability and adherence to CBT on outcomes and revealed the impact of subsequent treatment costs on model results after considering subsequent treatment of false negative patients.</p><p><strong>Conclusions: </strong>Whooley screening followed by referral to CBT for women screened positive is estimated to be cost-effective in identifying and treating women with postpartum depression at an early stage compared to TAU. More research is required to assess this strategy's feasibility, cost-benefit, and clinical effectiveness.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"1017"},"PeriodicalIF":3.4,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dignity violation of patients with schizophrenia: a grounded theory.","authors":"Elham Amiri, Rahim Baghaei, Hossein Habibzadeh, Hossein Ebrahimi","doi":"10.1186/s12888-025-07472-1","DOIUrl":"https://doi.org/10.1186/s12888-025-07472-1","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"1015"},"PeriodicalIF":3.4,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transdiagnostic eye-tracking biomarkers of inattention across psychiatric disorders: a systematic review.","authors":"Armin Toghi, Azar Mohammadzadeh, Zahra Alemi, Anahita Khorrami Banaraki","doi":"10.1186/s12888-025-07415-w","DOIUrl":"https://doi.org/10.1186/s12888-025-07415-w","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"1007"},"PeriodicalIF":3.4,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderating role of familial relationships in the efficacy of rTMS intervention on cognitive function in patients with schizophrenia.","authors":"Cheng Zhu, Jing Yao, Hengyong Guan, Fengchun Wu, Meihong Xiu","doi":"10.1186/s12888-025-07251-y","DOIUrl":"https://doi.org/10.1186/s12888-025-07251-y","url":null,"abstract":"<p><strong>Background: </strong>It has been hypothesized that rTMS improves cognitive performance in SCZ by altering neuronal activity through magnetic field pulses. However, these findings were controversial. The present study examined whether familial relationships impacted the effect of rTMS targeting the left DLPFC on cognitive function improvement in patients with SCZ.</p><p><strong>Methods: </strong>A total of 84 SCZ patients were randomly allocated to the active rTMS or sham rTMS groups and received a 6-week intervention session. Patients were followed up at the end of the 24th week. Cognitive functions were evaluated at baseline and at the end of the 2nd, 6th, and 24th weeks. Patients' relationships with their family members were also evaluated.</p><p><strong>Results: </strong>Significant interactions of time × treatment on immediate memory and total scores were observed in patients with SCZ treated with rTMS. Active rTMS stimulation showed a beneficial effect on immediate memory in SCZ. In addition, we found that after controlling for confounding factors, patients with positive familial relationships experienced greater improvements in immediate memory after rTMS than those with negative relationships. More importantly, linear regression analysis revealed that familial relationship was a predictor of immediate memory improvement following rTMS intervention.</p><p><strong>Conclusions: </strong>Our results reveal that familial relationships significantly influence the outcome of rTMS treatment in patients with SCZ. Relative to patients with negative familial relationships, those with positive relationships showed greater cognitive improvement.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov, NCT03774927, registered on 20,181,211.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"1010"},"PeriodicalIF":3.4,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}