BMC Psychiatry最新文献

{"title":"Association between frailty and physical-psychological multimorbidity in middle-aged and elderly Chinese adults: a longitudinal study in Chinese middle-aged and older adults.","authors":"ZhiYing Fei, Ying Qian, YingYing Tu, ChunQiao Wu","doi":"10.1186/s12888-024-06398-4","DOIUrl":"https://doi.org/10.1186/s12888-024-06398-4","url":null,"abstract":"<p><strong>Background: </strong>As the population ages, chronic diseases, frailty, and physical-psychological multimorbidity (PP-MM) increase. However, the association between frailty and PP-MM remains unclear. This study aimed to investigate this relationship in middle-aged and elderly Chinese individuals.</p><p><strong>Methods: </strong>This study used four waves of data from the Chinese Longitudinal Study of Health and Aging. The main measures included frailty by the frailty index(FI) constructed using 40 indicators. PP-MM was defined as the concurrent presence of two kinds of diseases (physical illness and psychological disorders). The relationship between FI and PP-MM was evaluated using COX risk regression models and restricted cubic spline (RCS) curves and P < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>This study included 10,707 subjects, and after adjusting for potential confounders, the HR was 3.01 (95% confidence interval (CI) = 2.05-4.23) for pre-frail and 6.11 (95% CI = 3.79-9.84) for frail. COX regression analysis indicated a potential association between FI and PP-MM progression. RCS analysis revealed that the risk of PP-MM prevalence increased faster with an FI between 0.10 and 0.25.</p><p><strong>Conclusion: </strong>Our study suggests that FI is positively associated with the prevalence of PP-MM and that the pre-frail phase may be a better opportunity to implement interventions for PP-MM prevention, with early monitoring of FI to identify patients at high risk for PP-MM and to provide direction and rationale for preventing PP-MM.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"935"},"PeriodicalIF":3.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The limited clinical utility of a routine creatine kinase (CK) on admission to a psychiatric inpatient unit.","authors":"Fraser A M Scott, Matt Butler, Jonathan P Rogers","doi":"10.1186/s12888-024-06386-8","DOIUrl":"https://doi.org/10.1186/s12888-024-06386-8","url":null,"abstract":"<p><strong>Background: </strong>Creatine kinase (CK) is an intracellular enzyme expressed most commonly in tissues such as skeletal muscle. CK can be used as an investigation to support the diagnosis of conditions such as neuroleptic malignant syndrome (NMS), a rare idiosyncratic drug reaction - classically to antipsychotic medications - which can be fatal. Routine screening of CK in psychiatric inpatients is a known practice, but its value is uncertain. We aimed to ascertain whether such screening resulted in new diagnoses of NMS or other conditions, and changes in clinical management.</p><p><strong>Methods: </strong>Using an electronic case register, we conducted a descriptive retrospective cohort study, identifying all psychiatric inpatient admissions in a South London mental health trust over a four-year period where a CK test was conducted within 48 h of admission. We extracted the demographic and clinical characteristics (e.g., diagnosis) of those who met inclusion criteria. Free-text review was performed on all those with a CK potentially suggestive of NMS (CK ≥ 4x upper limit of normal reference range (ULN)) to determine the impact of this abnormal result on subsequent management and diagnosis (including NMS if identified).</p><p><strong>Results: </strong>Of 14,236 inpatient episodes in the specified window, 2358 (16.6%) had a CK test within 48 h of admission. This was ≥ 4x ULN in 327 (13.8%) cases (free-text successfully reviewed in 318). There were no cases of NMS identified. An abnormal CK result led to a new alternative diagnosis, such as dehydration or catatonia, in only 14 patients (4.4% raised CK sample, 0.6% total CK sample). Impact on subsequent management appeared limited, with the most common adjustment being an increase in frequency of physical observations in 47 instances (14.8%).</p><p><strong>Conclusions: </strong>The clinical utility of untargeted screening using a serum CK for psychiatric inpatients appears limited, with poor specificity in detection of NMS and a minimal impact on subsequent clinical management.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"908"},"PeriodicalIF":3.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between clinician and machine learning prediction in a randomized controlled trial for nonsuicidal self-injury.","authors":"Moa Pontén, Oskar Flygare, Martin Bellander, Moa Karemyr, Jannike Nilbrink, Clara Hellner, Olivia Ojala, Johan Bjureberg","doi":"10.1186/s12888-024-06391-x","DOIUrl":"https://doi.org/10.1186/s12888-024-06391-x","url":null,"abstract":"<p><strong>Background: </strong>Nonsuicidal self-injury is a common health problem in adolescents and associated with future suicidal behavior. Predicting who will benefit from treatment is an urgent and a critical first step towards personalized treatment approaches. Machine-learning algorithms have been proposed as techniques that might outperform clinicians' judgment. The aim of this study was to explore clinician predictions of which adolescents would abstain from nonsuicidal self-injury after treatment as well as how these predictions match machine-learning algorithm predictions.</p><p><strong>Methods: </strong>Data from a recent trial evaluating an internet-delivered emotion regulation therapy for adolescents with nonsuicidal self-injury was used. Clinician predictions of which patients would abstain from nonsuicidal self-injury (measured using the youth version of Deliberate Self-harm Inventory) were compared to a random forest model trained on the same available data from baseline assessments.</p><p><strong>Results: </strong>Both clinician (accuracy = 0.63) and model-based (accuracy = 0.67) predictions achieved significantly better accuracy than a model that classified all patients as reaching NSSI remission (accuracy = 0.49 [95% CI 0.41 to 0.58]), however there was no statistically significant difference between them. Adding clinician predictions to the random forest model did not improve accuracy. Emotion dysregulation was identified as the most important predictor of nonsuicidal self-injury absence.</p><p><strong>Conclusions: </strong>Preliminary findings indicate comparable prediction accuracy between clinicians and a machine-learning algorithm in the psychological treatment of nonsuicidal self-injury in youth. As both prediction approaches achieved modest accuracy, the current results indicate the need for further research to enhance the predictive power of machine-learning algorithms. Machine learning model indicated that emotion dysregulation may be of importance in treatment planning, information that was not available from clinician predictions.</p><p><strong>Trial registration: </strong>NCT03353961|| https://www.</p><p><strong>Clinicaltrials: </strong>gov/ , registered 2017-11-21. Preregistration at Open Science Framework: https://osf.io/vym96/ .</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"904"},"PeriodicalIF":3.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of a non-immersive virtual reality-based neuropsychological intervention for cognitive stimulation and relaxation in patients with critical illness: study protocol of a randomized clinical trial (RGS-ICU).","authors":"Marta Godoy-González, Josefina López-Aguilar, Sol Fernández-Gonzalo, Gemma Gomà, Lluís Blanch, Santiago Brandi, Sergi Ramírez, Joel Blasi, Paul Verschure, Gemma Rialp, Miquel Roca, Margalida Gili, Mercè Jodar, Guillem Navarra-Ventura","doi":"10.1186/s12888-024-06360-4","DOIUrl":"https://doi.org/10.1186/s12888-024-06360-4","url":null,"abstract":"<p><strong>Background: </strong>Experiencing a critical illness may be a stressful life event that is also associated with cognitive dysfunction during and after the intensive care unit (ICU) stay. A deep-tech solution based on non-immersive virtual reality, gamification and motion capture called Rehabilitation Gaming System for Intensive Care Units (RGS-ICU) has been developed that includes both cognitive stimulation and relaxation protocols specifically designed for patients with critical illness. This study aims to evaluate whether the cognitive and relaxation protocols of the RGS-ICU platform are 1) effective in improving neuropsychological outcomes during and after ICU stay and 2) safe for patients with critical illness.</p><p><strong>Methods: </strong>This is a study protocol for a multicenter longitudinal randomized clinical trial. At least 80 patients with critical illness will be included: 40 experimental subjects and 40 control subjects. Patients in the experimental group will receive daily 20-min sessions of cognitive stimulation and relaxation with the RGS-ICU platform adjuvant to standard ICU care in their own rooms during the ICU stay and until discharge from the ICU or up to a maximum of 28 days after randomization, provided they are alert and calm. Patients in the experimental group will be constantly monitored as part of standard ICU care to ensure the safety of the intervention and that no avoidable adverse events occur. Patients in the control group will receive standard ICU care. The primary outcome is objective cognition 12 months after ICU discharge, assessed with a composite index including measures of attention, working memory, learning/memory, executive function and processing speed. The secondary outcome is the safety of the intervention, assessed by considering the number of sessions terminated early due to unsafe events in physiological parameters. Other outcomes are comfort experienced during the ICU stay, and subjective cognition, mental health (anxiety, depression and post-traumatic stress disorder), functionality and health-related quality of life 12 months after ICU discharge.</p><p><strong>Discussion: </strong>The expected results are 1) better neuropsychological outcomes during and after the ICU stay in patients in the experimental group compared to patients in the control group and 2) that the cognitive and relaxation protocols of the RGS-ICU platform are safe for patients with critical illness.</p><p><strong>Trial registration: </strong>Clinicaltrials.gov NCT06267911. Registered on February 20, 2024.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"917"},"PeriodicalIF":3.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influential factors of depression among caregivers of children with Cleft Lip and/or Palate: a path analysis based on diathesis-stress theoretical model.","authors":"Jinrong Yang, Xiaohan Li, Yuqin Gao, Weiren Wang, Junyan Wang, Yanjie Wang, Caixia Gong, Runzi Wang, Lulu Yuan","doi":"10.1186/s12888-024-06383-x","DOIUrl":"https://doi.org/10.1186/s12888-024-06383-x","url":null,"abstract":"<p><strong>Background: </strong>Depression is the most common psychological phenomenon among caregivers of children with Cleft Lip and/or Palate and affects the quality of life, treatment satisfaction, children's self-esteem and parent-child relationship. However, Existing studies have limited explanations for the mechanisms that lead to depression in caregivers of children with Cleft Lip and/or Palate. The present study aimed to identify factors influencing depression among caregivers of children with Cleft Lip and/or Palate and to provide a reference point and new ideas for future research.</p><p><strong>Methods: </strong>This cross-sectional study investigated 248 caregivers at two Cleft Lip and/or Palate treatment centers in China, spanning from April 2019 to July 2020. The diathesis-stress model was used to construct the model, and data analysis was conducted using SPSS 26.0 and AMOS 25.0. Path analysis was employed to test the hypothetical model, and the fit of the model was evaluated using Chi-Square/degree of freedom, Goodness-of-Fit Index, Normed Fit Index, Relative Fit Index, Incremental Fit Index, Tacker-Lewis Index, Comparative Fit Index and Root Mean Square Error of Approximation.</p><p><strong>Results: </strong>The study found that the average level of depression among caregivers of children with Cleft Lip and/or Palate was 4.83 (4.79). Additionally, 43.5% of caregivers exhibited depressive symptoms. The fit of the modified path model was found to be satisfactory, with the following indices: Chi-Square/degree of freedom = 1.881, Goodness-of-Fit Index = 0.986, Normed Fit Index = 0.973, Relative Fit Index = 0.919, Incremental Fit Index = 0.987, Tucker-Lewis Index = 0.960, Comparative Fit Index = 0.987, and Root Mean Square Error of Approximation (RMSEA) = 0.060. The results indicated that parenting stress had the greatest direct impact on depression, followed by hope. Indirect effects on depression were observed for optimism, resilience, and coping, which were mediated through perceived social support and parenting stress.</p><p><strong>Conclusions: </strong>This study suggests that depression in caregivers of children with Cleft Lip and/or Palate was leadingly influenced by parenting stress and hope. Strategies aimed at the key factors are expected to decrease depression.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"911"},"PeriodicalIF":3.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Trends in medically serious suicide attempts before and after COVID-19: a four-year retrospective analysis (2018-2022).","authors":"Anna Beneria, Luis Marte, Marta Quesada-Franco, Sara García-González, Damià Restoy, Citlalli Pérez-Galbarro, Olga Santesteban-Echarri, Rosa Ramos, Josep Antoni Ramos-Quiroga, María Dolores Braquehais","doi":"10.1186/s12888-024-06323-9","DOIUrl":"https://doi.org/10.1186/s12888-024-06323-9","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"903"},"PeriodicalIF":3.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mediating effect of sleep quality on the relationship between social support and depressive symptoms among Chinese nurses during the omicron outbreak.","authors":"Yingying Gu, Pinglang Hu, Huanzeng Ren, Caijun Dai, Xuejiao He, Weizhen Cheng, Lihua Yu, Achang Fang, Xiaoling Meng, Meiyang Lou, Youying Chen, Danli Chi, Huasu Zhou, Qiaoge Chen, Shuhong Ni, Qiqi Huang","doi":"10.1186/s12888-024-06326-6","DOIUrl":"https://doi.org/10.1186/s12888-024-06326-6","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic has led to increased depressive symptoms and diminished sleep quality among nurses. This study explores the relationships among social support, sleep quality, and depressive symptoms among Chinese nurses during the COVID-19 outbreak, with a focus on the mediating role of sleep quality.</p><p><strong>Methods: </strong>A cross-sectional study involving 2140 nurses was conducted from August to September 2022. The participants completed the Social Support Rating Scale, the Hospital Anxiety and Depression Scale, and the Pittsburgh Sleep Quality Index. The data were analyzed via serial multiple mediation analysis with the PROCESS macro in SPSS.</p><p><strong>Results: </strong>Depressive symptoms affected an estimated 40.4% of the participants, with 69.2% reporting poor sleep quality. The present study revealed a significant negative correlation between social support and sleep quality and depressive symptoms (r = -0.229, p < 0.001; r = -0.322, p < 0.001, respectively). Furthermore, a substantial positive correlation was observed between sleep quality and depressive symptoms (r = 0.514, p < 0.001). Additionally, social support had a significant indirect effect on depressive symptoms through sleep quality (standardized effect = -0.0535, 95% CI = [-0.0648, -0.0424]). Sleep quality was found to mediate the relationship between social support and depressive symptoms in all subgroups, with variations based on years of experience, education levels, and hospital type.</p><p><strong>Conclusion: </strong>Depressive symptoms were inversely associated with social support, which was moderated by sleep quality. Interventions targeting social support provision and sleep quality promotion are suggested for managing depressive symptoms among nurses during the COVID-19 pandemic.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"915"},"PeriodicalIF":3.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot study of a gratitude journaling intervention to enhance spiritual well-being and exercise self-efficacy in Black breast cancer survivors.","authors":"Lakeshia Cousin, Dejana Braithwaite, Stephen Anton, Zhongyue Zhang, Ji-Hyun Lee, Christiaan Leewenburgh, Debra Lyon","doi":"10.1186/s12888-024-06362-2","DOIUrl":"https://doi.org/10.1186/s12888-024-06362-2","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer (BC) survivorship presents significant health disparities, particularly affecting Black women, who experience a 40% higher BC death rate compared to White women. These disparities are exacerbated by comorbidities, which contribute to poorer overall health outcomes. Additionally, Black BC survivors often face psychosocial challenges, including increased stress and lower well-being, which can lead to adverse physical health effects. This pilot study aims to assess the feasibility and efficacy of a culturally sensitive gratitude journaling intervention designed to enhance spiritual well-being, exercise self-efficacy, and reduce inflammation among Black BC survivors.</p><p><strong>Methods: </strong>This pilot study employed a two-group, parallel random-assignment experimental design to compare a gratitude journaling intervention with a general memory journaling control group. Twenty-six Black women aged 40 to 70 years with a history of BC were randomly assigned to either the gratitude journaling intervention group (n = 13) or the control group (n = 13). The gratitude intervention group engaged in gratitude journaling twice weekly for eight weeks, while the control group documented daily memories. Outcomes measured included Gratitude Questionnaire-6, FACIT-Spiritual Well-Being 12 Item Scale, Perceived Stress Scale, Giscombe Superwoman Schema Questionnaire, and the Stage of Motivational Readiness for Physical Activity questionnaire and inflammatory biomarkers. Statistical analyses included the Wilcoxon rank sum test and Fisher's exact test.</p><p><strong>Results: </strong>Twenty-six participants were enrolled, with 73% completing baseline and post-intervention assessments. The intervention group showed a significant improvement in spiritual well-being (p = 0.014) with a large effect size (ES = 0.57). Marginal improvements in exercise self-efficacy were also observed (ES = 0.39). Although there were no significant differences in dispositional gratitude and perceived stress between groups, the intervention group exhibited trends toward increased gratitude and reduced stress. Inflammatory biomarker analysis indicated non-significant changes, though IL-6 levels increased in the intervention group.</p><p><strong>Conclusion: </strong>This study demonstrates the feasibility and acceptability of a gratitude journaling intervention among Black BC survivors. The intervention significantly enhanced spiritual well-being and showed promise in improving exercise self-efficacy, suggesting its potential for promoting holistic wellness in this population. These findings provide a foundation for future larger-scale randomized controlled trials to further evaluate the efficacy of gratitude-based interventions for Black BC survivors.</p><p><strong>Trial registration: </strong>This study was registered prospectively at ClinicalTrials.gov (NCT05473026) on 07-13-2022.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"931"},"PeriodicalIF":3.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between serum uric acid and risk of depressive symptoms in East Asian populations.","authors":"Menghui Yao, Xinxin Han, Yue Yin, Shuolin Wang, Yingdong Han, He Zhao, Hong Di, Juan Wu, Yun Zhang, Xuejun Zeng","doi":"10.1186/s12888-024-06343-5","DOIUrl":"https://doi.org/10.1186/s12888-024-06343-5","url":null,"abstract":"<p><strong>Background: </strong>Despite the fact that observational studies have reported associations between serum uric acid (SUA) and depressive symptoms risk in East Asian populations, there is a lack of evidence demonstrating a causal relationship between them. This study aimed to perform a comprehensive assessment of the relationship between SUA and depressive symptoms.</p><p><strong>Methods: </strong>This study included two cohort studies and a two-sample Mendelian randomization study. The cross-sectional cohort was derived from the China Health and Retirement Longitudinal Study (CHARLS) wave 3 (in 2015), and the baseline data of participants were extracted from the CHARLS wave 1(in 2011), excluding those with depressive symptoms in 2011 and forming a longitudinal cohort from 2011 to 2015. Logistic multiple regression was performed to investigate the cross-sectional and longitudinal associations of SUA with depressive symptoms in the two cohorts. Furthermore, we performed two-sample Mendelian randomization analyses to explore the potential causal relationships between them.</p><p><strong>Results: </strong>We included two cohorts of 9056 and 3177 individuals respectively. Logistic regression showed that individual with higher SUA levels had a lower risk of depressive symptoms (OR = 0.921; 95%CI: 0.886-0.957) in the cross-sectional cohort. However, neither the baseline SUA level (OR = 1.055, 95%CI: 0.961-1.157) nor the change in SUA level (OR = 0.945, 95%CI: 0.656-1.363) affected the depressive symptoms 4 years later in the longitudinal cohort. The two-sample MR showed that there was no genetic causal relationship between SUA and depression (OR_{IVW_MRE}= 1.071, 95% CI: 0.926-1.238).</p><p><strong>Conclusions: </strong>SUA and depressive symptoms are associated, with lower SUA levels observed in middle-aged and older participants with depressive symptoms; however, no causal evidence supports their relationship.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"930"},"PeriodicalIF":3.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden of Alzheimer's disease and other dementias attributed to metabolic risks from 1990 to 2021: results from the global burden of disease study 2021.","authors":"Xinyi Zhang, Tongtong Guo, Ya Zhang, Min Jiao, Lihong Ji, Zhiwei Dong, Haiyan Li, Shanquan Chen, Wengui Zheng, Qi Jing","doi":"10.1186/s12888-024-06375-x","DOIUrl":"https://doi.org/10.1186/s12888-024-06375-x","url":null,"abstract":"<p><strong>Objective: </strong>The risk of Alzheimer's disease (AD) and other dementias increases with greater global exposure to metabolic risks, making this a crucial public health issue. This study aimed to report the metabolism-attributable global burden of AD and other dementias from 1990 to 2021.</p><p><strong>Methods: </strong>The Global Burden of Disease Study (GBD) 2021 collected data on the number of deaths and disability-adjusted life-years (DALYs) related to AD and other dementias caused by metabolic risks, including high fasting plasma glucose (FPG) and high body mass index (BMI). The analysis assessed the disease burden and temporal patterns worldwide, examining data by region, country, level of social development, age group, and sex.</p><p><strong>Results: </strong>Globally, the count of AD and other dementia-related deaths due to metabolic risks grew from 98,608 to 399,824, a 4.1-fold increase. For dementias related to high FPG and high BMI, the age-standardized mortality rates (ASMR) and age-standardized DALY rate (ASDR) increased with age and were higher in females than in males. In 2021, the highest burden was observed in high-income North America. The ASMR and ASDR have grown worldwide between 1990 and 2021. The burden of metabolism-related AD and other dementias was positively correlated with the Socio-Demographic Index (SDI), with higher ASMR and ASDR in high SDI regions but showing more pronounced increases in low and low-middle SDI regions.</p><p><strong>Conclusions: </strong>Metabolism-related global burden of AD and other dementias is increasing, particularly among women and in high-income regions. Targeted prevention programs for dementia should be developed, along with early interventions for risk factors.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"910"},"PeriodicalIF":3.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}