抑郁发作期间单极抑郁症和双相II型障碍事件相关电位的差异：一项回顾性病例对照研究

IF 3.4 2区医学 Q2 PSYCHIATRY

BMC Psychiatry Pub Date : 2025-10-22 DOI:10.1186/s12888-025-07433-8

Xiaobo Zhou, Jingwen Liu, Zhonghua Lin, Minjing Xiang, Xia Deng, Zhili Zou

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引用次数: 0

摘要

背景：双相情感障碍（BD II）是一种慢性重度精神疾病，由于症状重叠和缺乏客观诊断工具，常被误诊为重度抑郁症（MDD）。因此，建立病理生理标志物来区分双相障碍和重度抑郁症是至关重要的。方法：共有180名患者被纳入研究，并被分为三组：单相抑郁症患者（UD组；重度抑郁症患者，n = 60），抑郁发作期间的双相情感障碍患者（BD II组，n = 60），以及年龄和性别匹配的健康对照组（HC, n = 60）。收集社会人口统计数据，并使用7项广泛性焦虑障碍（GAD-7）、患者健康问卷-9 （PHQ-9）和32项轻躁狂检查表（HCL-32）对所有参与者进行心理评估。此外，所有参与者均通过听觉脑干反应（ABR）测试，随后进行事件相关电位（ERP）测试。结果：三组患者年龄、性别、文化程度、婚姻状况、社会经济状况等人口学特征差异均无统计学意义（P < 0.05）。与HC相比，在P300模式下，UD组和BD II组患者的反应时间（HC: 254.4±43.8 ms; UD: 297.7±72.2 ms; BD II: 3000.3±70.0 ms, P = 0.028）和P2-N2复合物振幅（HC: 5.7±4.4 μV; UD: 8.1±4.8 μV; BD II: 8.6±5.6 μV, P = 0.001）均显著延长。BD II组S2-P50潜伏期较UD组长（UD: 50.4±11.1 ms vs BD II: 63.2±11.5 ms; P = 0.025）。此外，与HC相比，BD II组N2潜伏期延长（BD II: 216.2±22.1 ms vs HC: 205.2±16.5 ms; P = 0.044）。结论：本研究可能确定了BD II和UD抑郁之间的神经生理差异，特别是BD II中S2-P50潜伏期延长。

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Differences in event-related potentials between unipolar depression and bipolar II disorder during depressive episodes: a retrospective case-control study.

Background: Bipolar II disorder (BD II) is a chronic and severe mental illness frequently misdiagnosed as major depressive disorder (MDD) due to symptom overlap and the absence of objective diagnostic tools. Consequently, establishing pathophysiological markers to differentiate BD II from MDD is critical.

Method: A total of 180 patients were enrolled in the study and allocated to three groups: patients with unipolar depression (UD group; MDD currently experiencing a major depressive episode, n = 60), patients with bipolar II disorder during depressive episodes (BD II group; n = 60), and age- and sex- matched healthy controls (HC; n = 60). Sociodemographic data were collected, and all participants underwent psychological assessments using the 7-item Generalized Anxiety Disorder (GAD-7), Patient Health Questionnaire-9 (PHQ-9), and 32-item Hypomania Checklist (HCL-32). Additionally, all participants passed auditory brain stem response (ABR) test and subsequently underwent event-related potential (ERP) examinations.

Results: No significant differences were observed in demographic characteristics between the three groups, including age, sex, educational level, marital status, and socioeconomic status (all P > 0.05). Compared with HC, patients in both the UD and BD II groups showed significantly longer reaction time (HC: 254.4 ± 43.8 ms; UD: 297.7 ± 72.2 ms; BD II: 300.3 ± 70.0 ms; P = 0.028) and larger amplitude of P2-N2 complex (HC: 5.7 ± 4.4 μV; UD: 8.1 ± 4.8 μV; BD II: 8.6 ± 5.6 μV; P = 0.001) in P300 paradigm. The BD II group exhibited longer S2-P50 latency than the UD group (UD: 50.4 ± 11.1 ms vs. BD II: 63.2 ± 11.5 ms; P = 0.025). Additionally, the BD II group had prolonged N2 latency compared to HC (BD II: 216.2 ± 22.1 ms vs. HC: 205.2 ± 16.5 ms; P = 0.044).

Conclusions: This study may identify neurophysiological distinctions between BD II and UD depression, notably a prolonged S2-P50 latency in BD II.

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来源期刊

BMC Psychiatry 医学-精神病学

CiteScore

5.90

自引率

4.50%

发文量

716

审稿时长

3-6 weeks

期刊介绍： BMC Psychiatry is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of psychiatric disorders, as well as related molecular genetics, pathophysiology, and epidemiology.