Psychotropic-associated delusional pseudo-gender dysphoria: a case report.

IF 3.4 2区医学 Q2 PSYCHIATRY

BMC Psychiatry Pub Date : 2025-10-10 DOI:10.1186/s12888-025-07450-7

Karim Abdel Aziz, Abeer Saleh Al Ammari, Mouza Sultan Alzaabi, Farah Jamal Al Naqbi, Mariam MohamedObadah Adi, Fatima Saleh Aljaberi, Zakaria Husam Ouda, Emmanuel Stip

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引用次数: 0

Abstract

Background: Gender dysphoric delusions are reported in about 20-25% of patients with schizophrenia. There have been no previous cases of psychotropics contributing to the occurrence of gender dysphoric delusions or cases where two different types of gender dysphoric delusions occur in the same patient at different times.

Case presentation: We report on a 30-year-old female with bipolar disorder who after being maintained on sodium valproate and once-monthly paliperidone, experienced side effects in the form of hirsutism (facial hair) and amenorrhea. After discontinuing them, she started reporting that her lower half was female and her upper half was male, then began to identify as "a man trapped in a woman's body" and expressed a desire to undergo gender affirming surgery. Treatment with a clozapine resulted in her identifying once again as 100% female.

Conclusions: This is the first case to report on the contribution of psychotropics in the development of gender dysphoric delusions and is also the first to report on two different types of gender dysphoric delusions occurring in the same patient at different times, with initial delusions of simultaneously belonging to both genders and then delusions of belonging to the opposite gender only.

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精神科相关妄想性伪性别焦虑症1例报告。

背景：约20-25%的精神分裂症患者存在性别焦虑妄想。以前没有精神药物导致性别焦虑妄想发生的病例，也没有同一患者在不同时间出现两种不同类型的性别焦虑妄想的病例。病例介绍：我们报告了一位30岁的女性双相情感障碍患者，在维持丙戊酸钠和每月一次的帕利哌酮治疗后，出现了多毛（面部毛发）和闭经的副作用。停药后，她开始报告自己的下半身是女性，上半身是男性，然后开始认为自己是“困在女人身体里的男人”，并表达了接受性别确认手术的愿望。氯氮平治疗使她再次被确认为100%女性。结论：本病例首次报道精神药物在性别焦虑症妄想发展中的作用，也是首次报道同一患者在不同时间出现两种不同类型的性别焦虑症妄想，初始妄想同时属于两性，然后妄想只属于异性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Psychiatry 医学-精神病学

CiteScore

5.90

自引率

4.50%

发文量

716

审稿时长

3-6 weeks

期刊介绍： BMC Psychiatry is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of psychiatric disorders, as well as related molecular genetics, pathophysiology, and epidemiology.