BioPsychoSocial Medicine最新文献

{"title":"My memories of the Benson-Henry institute for mind-body medicine.","authors":"Mutsuhiro Nakao","doi":"10.1186/s13030-023-00270-9","DOIUrl":"10.1186/s13030-023-00270-9","url":null,"abstract":"","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9577710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individualized peer support needs assessment for families with eating disorders.","authors":"Chisato Ohara,&nbsp;Aya Nishizono-Maher,&nbsp;Atsushi Sekiguchi,&nbsp;Ayako Sugawara,&nbsp;Yuriko Morino,&nbsp;Junko Kawakami,&nbsp;Mari Hotta","doi":"10.1186/s13030-023-00267-4","DOIUrl":"https://doi.org/10.1186/s13030-023-00267-4","url":null,"abstract":"<p><strong>Background: </strong>Peer support among family members is important in cases of mental illness, but there has been limited practice or research on individual peer support specific to families taking care of patients with eating disorders (EDs). To conduct peer support activities, it is necessary to clarify the needs of families.</p><p><strong>Objectives: </strong>The objective of this study are to identify the needs for group and individual peer support and the characteristics of family members with EDs who are willing to receive and provide individual peer support.</p><p><strong>Method: </strong>A cross-sectional questionnaire survey was conducted for family members with EDs recruited via the Internet. The questionnaires included demographic information on respondents and their patients, questions about the need for family peer support, interest in offering peer support, and social resources. All participants were given the General Health Questionnaire (GHQ-12), the Zarit Caregiver Burden Interview (J-ZBI_8), and the Anorectic Behavior Observation Scale (ABOS).</p><p><strong>Results: </strong>Out of 314 respondents, 87.3% believed that a group peer support system was necessary, whereas 56.7% believed that an individual peer support system was necessary. As to whether they want to use individual peer support, 70 (22.4%) stated \"Extremely YES\" and 99 (31.7%) stated \"Moderately YES.\" Family members who were willing to receive individual peer support used more social resources and had higher scores on the GHQ and J-ZBI_8. Regarding the provision of peer support, 38 (12.2%) responded \"very interested and willing to provide it if possible\" and 87 (27.9%) responded \"interested and willing to study.\" Those with a high willingness to provide peer support used more social resources and had lower ABOS scores; however, 38 respondents (45.7%) exceeded the GHQ mental health screening cutoff (3/4).</p><p><strong>Conclusion: </strong>Family members with ED had a strong need for family peer support Those willing to receive individual peer support suffered from poor mental health and high burden of care. Family members willing to provide peer support tended to have patients whose EDs symptoms had already improved, but their own mental health was not necessarily good. Training for potential peer supporters is needed to implement peer support.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10012548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9124659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of eating together online on autonomic nervous system functions: a randomized, open-label, controlled preliminary study among healthy volunteers.","authors":"Hideaki Hasuo,&nbsp;Nahoko Kusaka,&nbsp;Mutsuo Sano,&nbsp;Kenji Kanbara,&nbsp;Tomoki Kitawaki,&nbsp;Hiroko Sakuma,&nbsp;Tomoya Sakazaki,&nbsp;Kohei Yoshida,&nbsp;Hisaharu Shizuma,&nbsp;Hideo Araki,&nbsp;Motoyuki Suzuki,&nbsp;Satoshi Nishiguchi,&nbsp;Masaki Shuzo,&nbsp;Gaku Masuda,&nbsp;Kei Shimonishi,&nbsp;Kazuaki Kondo,&nbsp;Hirotada Ueda,&nbsp;Yuichi Nakamura","doi":"10.1186/s13030-023-00263-8","DOIUrl":"https://doi.org/10.1186/s13030-023-00263-8","url":null,"abstract":"<p><strong>Background: </strong>Eating alone has been significantly associated with psychological distress. However, there is no research that evaluates the effects or relation of eating together online to autonomic nervous system functions.</p><p><strong>Methods: </strong>This is a randomized, open-label, controlled, pilot study conducted among healthy volunteers. Participants were randomized into either an eating together online group or an eating-alone group. The effect of eating together on autonomic nervous functions was evaluated and compared with that of the control (eating alone). The primary endpoint was the change in the standard deviation of the normal-to-normal interval (SDNN) scores among heart rate variabilities (HRV) before and after eating. Physiological synchrony was investigated based on changes in the SDNN scores.</p><p><strong>Results: </strong>A total of 31 women and 25 men (mean age, 36.6 [SD = 9.9] years) were included in the study. In the comparison between the aforementioned groups, two-way analysis of variance revealed interactions between time and group on SDNN scores. SDNN scores in the eating together online group increased in the first and second halves of eating time (F[1,216], P < 0.001 and F[1,216], P = 0.022). Moreover, high correlations were observed in the changes in each pair before and during the first half of eating time as well as before and during the second half of eating time (r = 0.642, P = 0.013 and r = 0.579, P = 0.030). These were statistically significantly higher than those in the eating-alone group (P = 0.005 and P = 0.040).</p><p><strong>Conclusions: </strong>The experience of eating together online increased HRV during eating. Variations in pairs were correlated and may have induced physiological synchrony.</p><p><strong>Trial registration: </strong>The University Hospital Medical Information Network Clinical Trials Registry, UMIN000045161. Registered September 1, 2021. https://center6.umin.ac.jp/cgi-open-bin/icdr/ctr_view.cgi?recptno=R000051592 .</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9087485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombocytopenia and PT-INR in patients with anorexia nervosa and severe liver dysfunction.","authors":"Ken Kurisu,&nbsp;Kaoruko Sato,&nbsp;Mikiko Matsuoka,&nbsp;Makoto Otani,&nbsp;Kazuhiro Yoshiuchi","doi":"10.1186/s13030-023-00269-2","DOIUrl":"https://doi.org/10.1186/s13030-023-00269-2","url":null,"abstract":"<p><strong>Background: </strong>We previously reported a case that led us to hypothesize that decreased production of thrombopoietin (TPO) leads to thrombocytopenia in patients with anorexia nervosa (AN) with severe liver dysfunction and that prolonged prothrombin time-international normalized ratio (PT-INR) predicts thrombocytopenia in such cases. To validate this hypothesis, we report another case in which TPO levels were measured. In addition, we examined the association between prolonged PT-INR and thrombocytopenia in such patients.</p><p><strong>Main body: </strong>Similar to the previously reported patient, a patient with AN with severe liver dysfunction showed that TPO levels increased after improvements in liver enzyme levels and PT-INR, followed by recovery of platelet count. In addition, a retrospective study was also conducted to review patients with AN whose liver enzyme levels were > 3 × the upper limit of normal (aspartate aminotransferase > 120 U/L or alanine aminotransferase > 135 U/L). The study included 58 patients and showed a correlation coefficient of -0.486 (95% confidence interval [CI], -0.661 to -0.260; P < 0.001) between maximum PT-INR and minimum platelet count. These patients showed higher PT-INR (β, 0.07; 95% CI, 0.02 to 0.13; P = 0.005) and lower platelet count (β, -5.49; 95% CI, -7.47 to -3.52; P < 0.001) than the 58 matched control patients without severe liver dysfunction, even after adjusting for body mass index.</p><p><strong>Conclusions: </strong>In patients with AN with severe liver dysfunction, prolongation of PT-INR could predict thrombocytopenia, which may be mediated by decreased TPO production due to decreased hepatic synthetic function.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9078981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A patient who recovered from post-COVID myalgic encephalomyelitis/chronic fatigue syndrome: a case report.","authors":"Takakazu Oka","doi":"10.1186/s13030-022-00260-3","DOIUrl":"https://doi.org/10.1186/s13030-022-00260-3","url":null,"abstract":"<p><strong>Background: </strong>Some patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) complain of persistent fatigue, dyspnea, pain, and cognitive dysfunction. These symptoms are often described as \"long COVID\". Whether a patient with long COVID might develop myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is of interest, as is the treatment and management of ME/CFS in a post-COVID patient. Here I report a patient, who, after an infection with SARS-CoV-2, developed ME/CFS and recovered after treatment.</p><p><strong>Case presentation: </strong>The patient was a previously healthy 55-year-old woman who worked as a nurse and became ill with COVID-19 pneumonia. She then presented with severe fatigue, post-exertional malaise, dyspnea, pain, cognitive dysfunction, tachycardia, and exacerbation of fatigue on physical exertion, which persisted for more than 6 months after her recovery from COVID-19 pneumonia. She was bedridden for more than half of each day. The patient was treated from multiple perspectives, which included (1) instructions on eating habits and supplements; (2) cognitive and behavioral modifications for coping with physical, emotional, and cognitive fatigue; (3) instructions on conditioning exercises to improve deconditioning due to fatigue and dyspnea; and (4) pharmacotherapy with amitriptyline and hochuekkito, a Japanese herbal (Kampo) medicine. The patient made a complete recovery after completing the prescribed regimen and was able to return to work as a nurse.</p><p><strong>Conclusions: </strong>To the best of my knowledge, this is the first detailed report on a patient infected with SARS-CoV-2 followed by long COVID with the signs/symptoms of ME/CFS who recovered after treatment. I hope this case report will be helpful to health care practitioners by its presentation of some of the therapeutic options for alleviating disabling signs/symptoms in patients with post-COVID ME/CFS.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10820241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal separation and TNBS-induced gut inflammation synergistically alter the sexually differentiated stress response in rats.","authors":"Ryoko Hasegawa,&nbsp;Kumi Saito-Nakaya,&nbsp;Li Gu,&nbsp;Motoyori Kanazawa,&nbsp;Shin Fukudo","doi":"10.1186/s13030-022-00258-x","DOIUrl":"https://doi.org/10.1186/s13030-022-00258-x","url":null,"abstract":"<p><strong>Background: </strong>Neonatal maternal separation (MS) has been used to model long-lasting changes in behavior caused by neuroplastic changes associated with exposure to early-life stress. Earlier studies showed that transient gut inflammation can influence the development of irritable bowel syndrome (IBS). A prevailing paradigm of the etiology of IBS is that transient noxious events lead to long-lasting sensitization of the neural pain circuit, despite complete resolution of the initiating event. This study characterizes the changes in behaviors and neuroendocrine parameters after MS and early-phase trinitrobenzene sulfonic acid (TNBS)-induced colitis. We tested the hypothesis that MS and gut inflammation synergistically induce (1) hyperactivity in male rats and anxiety-like behaviors in female rats and (2) activation of the HPA axis in female rats and deactivation of the HPA axis in male rats after colorectal distention (CRD).</p><p><strong>Methods: </strong>Male and female rat pups were separated from their dams for 180 min daily from postnatal day (PND) 2 to PND 14 (MS). Early-phase colitis was induced by colorectal administration with TNBS on PND 8. The elevated plus-maze test was performed at 7 weeks. Tonic CRD was performed at 60 mmHg for 15 min at 8 weeks. Plasma ACTH and serum corticosterone were measured at baseline or after the CRD. Analysis of variance was performed for comparison among controls, TNBS, MS, and MS + TNBS.</p><p><strong>Results: </strong>In male rats, the time spent in open arms significantly differed among the groups (p < 0.005). The time spent in open arms in male MS + TNBS rats was significantly higher than that of controls (p < 0.009) or TNBS rats (p < 0.031, post hoc test). Female rats showed no difference in the time spent in open arms among the groups. MS and gut inflammation induced an increase in plasma ACTH in female rats but not in male rats at baseline.</p><p><strong>Conclusions: </strong>These findings suggest that MS and gut inflammation synergistically induce hyperactive behavior or exaggerated hypothalamic-pituitary-adrenal axis function depending on sex.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10798339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between self-rated depressive symptoms and mucosal expression of NF-κ B in patients with upper gastrointestinal symptoms.","authors":"Julia Staab,&nbsp;Lara Vonhören,&nbsp;Harald Schwörer,&nbsp;Thomas Meyer","doi":"10.1186/s13030-023-00264-7","DOIUrl":"https://doi.org/10.1186/s13030-023-00264-7","url":null,"abstract":"<p><strong>Background: </strong>Previous clinical studies have reported elevated levels of depressive symptoms in selected samples of patients with gastritis. The objective of this study was to examine the associations of specific biomarkers of inflammation expressed in mucosal tissue from the stomach with mood and anxiety symptoms in adult patients with upper gastrointestinal symptoms.</p><p><strong>Methods: </strong>In this monocentric, observational study, a total of 32 study participants were included who were referred for a routine diagnostic upper endoscopic assessment based on the suspected clinical diagnosis of gastritis. All participants completed the Hospital Anxiety and Depression Scale (HADS) before undergoing gastroscopy. Immunohistochemical stainings from biopsy sections were performed to evaluate the expression level of nuclear factor kappa B (NF-κ B), myeloperoxidase (MPO) and inducible nitric oxide synthase (iNOS).</p><p><strong>Results: </strong>Our findings confirmed that nearly half of the study cohort (n = 13; 41%) displayed positive HADS depression scores above the clinically relevant cut-off level of ≥ 8. Regression models demonstrated that depressive symptoms were significantly and positively associated with the expression level of NF-κ B in biopsies from the upper gastrointestinal tract.</p><p><strong>Conclusions: </strong>In summary, our study showed a significant association between NF-κ B expression and clinically relevant depressive symptoms in patients with gastritis, as assessed by a self-rated psychometric questionnaire. Further investigations are needed to confirm this relationship and to identify the pathophysiological mechanisms involved.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10788645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac autonomic and cortisol stress responses to real operations in surgeons: relationship with individual psychobiological characteristics and experience.","authors":"Luca Carnevali,&nbsp;Elena Bignami,&nbsp;Sara Gambetta,&nbsp;Margherita Barbetti,&nbsp;Matteo Procopio,&nbsp;Antonio Freyrie,&nbsp;Paolo Carbognani,&nbsp;Luca Ampollini,&nbsp;Andrea Sgoifo","doi":"10.1186/s13030-023-00266-5","DOIUrl":"https://doi.org/10.1186/s13030-023-00266-5","url":null,"abstract":"<p><strong>Background: </strong>Surgeons are exposed to high levels of intraoperative stress, which could compromise their psychological well-being in the long term. This study aimed at exploring the effects of real operations on the activity of stress response systems (i.e., cardiac autonomic function and hypothalamic-pituitary-adrenal axis) during and in the aftermath of surgery, and the moderating role of individual psychobiological characteristics and different levels of experience (senior vs expert surgeons).</p><p><strong>Methods: </strong>Heart rate, heart rate variability, and salivary cortisol measures (as indexes of cardiac autonomic and hypothalamic-pituitary-adrenal axis activity, respectively) were assessed during real operations and in the perioperative period in a sample of surgeons (n = 16). Surgeons' psychometric characteristics were collected using questionnaires.</p><p><strong>Results: </strong>Real operations triggered both cardiac autonomic and cortisol stress responses which were independent from surgeons' level of experience. Intraoperative stress responses did not affect cardiac autonomic activity during the following night but were associated with a blunted cortisol awakening response. Moreover, senior surgeons reported higher levels of negative affectivity and depressive symptoms than expert surgeons prior to the surgery. Lastly, the magnitude of heart rate responses to surgery positively correlated with scores on negative affectivity, depression, perceived stress, and trait anxiety scales.</p><p><strong>Conclusion: </strong>This exploratory study allows to put forward the hypotheses that in surgeons cardiac autonomic and cortisol stress responses to real operations (i) may be associated with specific individual psychological characteristics regardless of the level of experience, (ii) and may have a longer lasting impact on hypothalamic-pituitary-adrenal axis function with potential implications for surgeons' physical and psychological well-being.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10772527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between social support for mothers of patients with eating disorders and mothers' active listening attitude: a cohort study.","authors":"Fujika Katsuki,&nbsp;Atsurou Yamada,&nbsp;Masaki Kondo,&nbsp;Hanayo Sawada,&nbsp;Norio Watanabe,&nbsp;Tatsuo Akechi","doi":"10.1186/s13030-023-00262-9","DOIUrl":"https://doi.org/10.1186/s13030-023-00262-9","url":null,"abstract":"<p><strong>Background: </strong>Family members of patients with eating disorders, especially their mothers, experience heavy caregiving burdens associated with supporting the patient. We predict that increasing caregivers' support will have a positive effect on their active listening attitudes, mental health, loneliness, and self-efficacy. This study aimed to investigate differences in mothers' active listening attitudes, mental health, loneliness, and self-efficacy improvements between mothers who did and did not experience increased perceived social support.</p><p><strong>Main body: </strong>Participants were mothers of patients with eating disorders. Questionnaires for this cohort study were sent to the participants' homes at three time points (baseline, 9 months, and 18 months). The Japanese version of the Social Provision Scale (SPS-10) was used to evaluate social support, the Active Listening Attitude Scale (ALAS) for listening attitude, the UCLA Loneliness Scale (ULS) for loneliness, the General Self-Efficacy Scale (GSES) for self-efficacy, the Beck Depression Inventory (BDI-II) for depression symptoms, and the K6 for psychological distress. An unpaired t-test was used to determine whether participants' status differed between the groups that did and did not experience increased perceived social support. The mean age of the participants was 55.1 ± 6.7 (mean ± SD) years. The duration of their children's eating disorders was 7.6 ± 5.5 years. The degree of improvement for each variable (active listening attitude, loneliness, self-efficacy, depressive symptoms, and mental health) was the difference in each score (ALAS, ULS, GSES, BDI-II, and K6) from T1 to T3. The degree of improvement in active listening attitude and loneliness was significantly greater in the improved social support group than in the non-improved social support group (p < 0.002 and p < 0.012, respectively).</p><p><strong>Conclusions: </strong>Our findings indicate that increasing mothers' perceptions of social support will be associated with improving their active listening attitudes and loneliness.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9302747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Slight religiosity associated with a lower incidence of any fracture among healthy people in a multireligious country.","authors":"Daiki Kobayashi,&nbsp;Hironori Kuga,&nbsp;Takuro Shimbo","doi":"10.1186/s13030-023-00265-6","DOIUrl":"https://doi.org/10.1186/s13030-023-00265-6","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to evaluate the association between the degree of religiosity and subsequent fractures and a decrease in bone mineral density in a Japanese population.</p><p><strong>Methods: </strong>We conducted a retrospective longitudinal study at St. Luke's International Hospital in Tokyo, Japan, from 2005 to 2018. All participants who underwent voluntary health check-ups were included. Our outcomes were any fractures and the change in T-score from baseline to each visit. We compared these outcomes by the self-reported degree of religiosity (not at all; slightly; somewhat; very) and adjusted for potential confounders.</p><p><strong>Results: </strong>A total of 65,898 participants were included in our study. Their mean age was 46.2(SD:12.2) years, and 33,014(50.1%) were male. During a median follow-up of 2,500 days (interquartile range (IQR):987-3,970), 2,753(4.2%) experienced fractures, and their mean delta T-score was -0.03%(SD:18.3). In multivariable longitudinal analyses, the slightly religious group had a statistically lower adjusted odds ratio (AOR) for a fracture than the nonreligious group(AOR:0.81,95% confidence interval(CI):0.71 to 0.92).</p><p><strong>Conclusions: </strong>We demonstrated that slightly religious people, but not somewhat or very religious people, had a lower incidence of fracture than nonreligious individuals, although the T-scores were similar regardless of the degree of religiosity.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10751199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}