BioPsychoSocial Medicine最新文献

{"title":"Psychological flexibility as a moderator of the association between premenstrual dysphoric disorder, depression, anxiety, positive parenting, and negative parenting: a cross-sectional study.","authors":"Junko Okajima, Isa Okajima","doi":"10.1186/s13030-025-00327-x","DOIUrl":"https://doi.org/10.1186/s13030-025-00327-x","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate whether psychological flexibility moderates the relationship between premenstrual dysphoric disorder (PMDD) symptoms and depression, anxiety, positive parenting, and negative parenting.</p><p><strong>Methods: </strong>For this study, a sample of 1,538 menstruating mothers with children aged 0 to 3 years (227 with 0-year-olds, 428 with 1-year-olds, 409 with 2-year-olds, and 424 with 3-year-olds) was assessed utilizing the Premenstrual Dysphoric Disorder Scale (PMDDS), Parental Acceptance and Action Questionnaire (PAAQ), and Hospital Anxiety and Depression Scale (HADS).</p><p><strong>Results: </strong>The interaction effects between PMDDS and PAAQ scores were found to be significantly associated with anxiety and positive parenting, after controlling for other variables. Notably, higher PAAQ scores were associated with increased positive parenting, even in the presence of worsened PMDD symptoms. Furthermore, psychological flexibility, as measured by the PAAQ, had an independent effect on both depression and anxiety, though no moderating effect was observed.</p><p><strong>Conclusions: </strong>Interventions aimed at enhancing psychological flexibility may be beneficial for mothers with premenstrual dysphoric disorder who are raising infants and toddlers.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"19 1","pages":"6"},"PeriodicalIF":2.3,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corticotropin-releasing hormone receptor-1 antagonist attenuates visceral hypersensitivity induced by trinitrobenzene sulfonic acid colitis and maternal separation in rats.","authors":"Ryoko Hasegawa, Kumi Nakaya, Motoyori Kanazawa, Shin Fukudo","doi":"10.1186/s13030-025-00324-0","DOIUrl":"https://doi.org/10.1186/s13030-025-00324-0","url":null,"abstract":"<p><strong>Background: </strong>The prevailing paradigm for the etiology of irritable bowel syndrome is that transient noxious events lead to long-lasting sensitization of the neural pain circuit, despite complete resolution of the initiating event. In this study, we tested the hypotheses that (1) the combination of maternal separation (MS) and previous colorectal inflammation induces extensive visceral hypersensitivity in rats and (2) visceral hypersensitivity induced by maternal separation and previous colorectal inflammation in rats is mediated via the corticotropin-releasing hormone receptor-1 (CRH-R1) pathway.</p><p><strong>Methods: </strong>Male rat pups were separated from their dams from postnatal day 2 to postnatal day 21. Acute colitis was induced by colorectal administration of trinitrobenzene sulfonic acid (TNBS) or vehicle on postnatal day 8. On postnatal day 50, the visceromotor response was evaluated by electromyography of the abdominal muscle in response to graded (10-80 mmHg) and phasic colorectal distention (CRD) one time. The same experiments were repeated after administration of the selective CRH-R1 antagonist CP-154,526 (20 mg/kg) or vehicle at 45 min before CRD.</p><p><strong>Results: </strong>Compared with control rats, visceral perception was increased in MS + TNBS rats. MS + TNBS rats showed a significantly larger visceromotor response to phasic CRD with 40 mmHg, 60 mmHg, and 80 mmHg. Compared with vehicle administration in MS + TNBS rats, administration of CP-154,526 significantly attenuated this visceromotor response to CRD with 40 mmHg, 60 mmHg, and 80 mmHg.</p><p><strong>Conclusions: </strong>These findings suggest that the combination of previous colitis and early life stress induce visceral hypersensitivity, and that the CRH-R1 pathway may play a role in this sensitization.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"19 1","pages":"5"},"PeriodicalIF":2.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between maternal overprotection and premenstrual disorder: a machine learning based exploratory study.","authors":"Kaori Tsuyuki, Miho Egawa, Takuma Ohsuga, Akihiko Ueda, Kazuki Shimada, Tsukasa Ueno, Kazuko Hiyoshi, Keita Ueda, Masaki Mandai","doi":"10.1186/s13030-025-00326-y","DOIUrl":"10.1186/s13030-025-00326-y","url":null,"abstract":"<p><strong>Background: </strong>Premenstrual disorder (PMD), which includes premenstrual syndrome and premenstrual dysphoric disorder, has a complex pathogenesis and may be closely related to emotional cognition and memory. However, the mechanisms underlying these associations remain unclear. Therefore, this study used machine learning to explore the roles of various factors that are not typically considered risk-factors for PMD.</p><p><strong>Methods: </strong>A predictive model for PMD was constructed using a dataset of questionnaire responses and heartrate variability data collected from 60 participants during their follicular and luteal phases. Based on the Japanese version of the Premenstrual Symptom Screening Tool, the binary objective variable (PMD status) was defined as \"PMD\" for moderate-to-severe premenstrual syndrome and premenstrual dysphoric disorder and other conditions as \"non-PMD.\" The contribution of each feature to the predictive model was assessed using the Shapley Additive exPlanations (SHAP) model-interpretation framework.</p><p><strong>Results: </strong>Of the 58 participants (providing 117 data points), 17 (34 data points) were in the PMD group and 41 (83 data points) were in the non-PMD group. The area under the receiver operating characteristic curve was 0.90 (95% confidence interval: 0.82-0.98). Among the top 20 features with the highest SHAP values, six were associated with maternal bonding. Four of the six mother-related characteristics were associated with overprotection.</p><p><strong>Conclusions: </strong>Based on these findings, parental bonding experiences, including maternal overprotection, may be associated with the presence of PMD.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"19 1","pages":"4"},"PeriodicalIF":2.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of polycystic ovary syndrome on attention: an empirical investigation.","authors":"Maitreyi Redkar, Azizuddin Khan","doi":"10.1186/s13030-024-00320-w","DOIUrl":"10.1186/s13030-024-00320-w","url":null,"abstract":"<p><strong>Background: </strong>Polycystic Ovary Syndrome (PCOS) is an endocrinal dysfunction characterized by androgen excess, irregular or absent menstruation, and polycystic ovarian morphology. While extensive research is conducted on the biochemical and medical ramifications of PCOS. However, there is not much research on cognitive mechanisms, especially attention. Attention is the fundamental cognitive ability that influences other cognitive and psychological phenomena. Therefore, the present study attempts to investigate the effect of PCOS on attention.</p><p><strong>Methods: </strong>Flanker's task examining focussed attention and Posner's cueing task measuring divided attention was administered to 173 female participants, of which 101 constituted the PCOS group and the remaining were control. The Analysis of Variance was used to analyze the data.</p><p><strong>Results: </strong>These findings demonstrated that the PCOS group took longer in focused attention, 557.21 milliseconds (SD = 169.70), compared to the reaction time of 462.88 milliseconds (SD = 120.80) in divided attention. Concerning accuracy, the PCOS group made more errors in the focused attention task at 0.98 (SD = 0.41), while for the divided attention task, it was 0.99 (SD = 0.27).</p><p><strong>Conclusions: </strong>Women with PCOS showed more error and slower reaction time in focused attention.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"19 1","pages":"3"},"PeriodicalIF":2.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of computer adaptive tests to assess the psychological status of individuals with an eating disorder or type 2 diabetes.","authors":"Takeshi Horie, Ken Kurisu, Shuji Inada, Kenshi Kawahara, Yutaka Matsuyama, Hiroe Kikuchi, Yoshiharu Yamamoto, Toshimasa Yamauchi, Kazuhiro Yoshiuchi","doi":"10.1186/s13030-025-00325-z","DOIUrl":"10.1186/s13030-025-00325-z","url":null,"abstract":"<p><strong>Background: </strong>Individuals with type 2 diabetes and eating disorders must change their eating behaviors, which are often influenced by psychological factors like depression and anxiety. To efficiently assess daily psychological status, the present study aimed to develop computerized adaptive tests (CAT) based on item response theory (IRT).</p><p><strong>Methods: </strong>Individuals with depression, anxiety disorders, eating disorders, type 2 diabetes, and healthy persons participated in the study. Participants completed six questionnaires, including momentary and most recent one-week depression, anxiety, and positive affect. We selected items meeting the IRT assumptions, applied a graded response model, and conducted CAT simulations.</p><p><strong>Results: </strong>Across all six questionnaires, the CAT simulations used a smaller number of items and exhibited substantial Pearson's correlation coefficients exceeding 0.95 between simulated and full item-set mood status estimates. These estimated mood scores demonstrated satisfactory concurrent validity with the Hospital Anxiety and Depression Scale and sufficient discriminant validity between the clinical group and healthy controls.</p><p><strong>Conclusion: </strong>These findings suggest that these scales offer efficient measurement of the mood status of individuals with an eating disorder or type 2 diabetes.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"19 1","pages":"2"},"PeriodicalIF":2.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of high complement and low immunoglobulins with the clinical symptoms of patients with fibromyalgia.","authors":"Satoshi Izuno, Masako Hosoi, Kozo Anno, Takahiro A Kato, Nobuyuki Sudo, Kazufumi Yoshihara","doi":"10.1186/s13030-024-00321-9","DOIUrl":"10.1186/s13030-024-00321-9","url":null,"abstract":"<p><strong>Background: </strong>Fibromyalgia (FM) is a disease characterized by chronic widespread pain concomitant with various symptoms such as fatigue and anxiety. Although chronic inflammation has been implicated in the immunological abnormalities of FM, there are few human studies on complement and immunoglobulins. In this study, we investigated the immunological characteristics of FM patients and the association between their clinical symptoms and immunological indices, including complement and immunoglobulins.</p><p><strong>Methods: </strong>1) The serum 50% hemolytic complement activity (CH50), C3, C4, IgG, IgM, and hsCRP of 36 FM patients and 30 healthy sex- and age-matched controls (HC) were measured and compared. 2) Data from the Brief Pain Inventory (pain intention and pain interference subscales), the visual analog scale (VAS) (low back pain, knee pain, and fatigue), the State-Trait Anxiety Inventory and the Center for Epidemiologic Studies Depression Scale (anxiety and depression), and CH50, IgG, and hsCRP as immunological indices were acquired for 41 FM patients. Correlation analysis was done of the clinical symptom and immunological indices.</p><p><strong>Results: </strong>1) The FM group had significantly higher CH50 and lower IgG and IgM than the HC group after adjusting for body mass index (BMI). 2) Correlation analysis of immunological indices and clinical symptoms showed a positive, partial correlation between CH50 and fatigue and trait anxiety after adjusting for sex, age, and BMI.</p><p><strong>Conclusions: </strong>FM patients had higher CH50 and lower immunoglobulin levels than HCs. CH50 was also associated with the fatigue and trait anxiety of FM patients. Further studies are needed to determine whether changes in these immunological indices can be used as biomarkers and/or therapeutic targets for FM.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"19 1","pages":"1"},"PeriodicalIF":2.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of preconception premenstrual disorders with perinatal depression: an analysis of the perinatal clinical database of a single Japanese institution.","authors":"Takuma Ohsuga, Miho Egawa, Kaori Tsuyuki, Akihiko Ueda, Maya Komatsu, Yoshitsugu Chigusa, Haruta Mogami, Masaki Mandai","doi":"10.1186/s13030-024-00323-7","DOIUrl":"10.1186/s13030-024-00323-7","url":null,"abstract":"<p><strong>Background: </strong>Recent studies have identified premenstrual disorders (PMDs) as a risk factor for postpartum depression. However, routine screening for preconception PMDs is not yet common in Japan. This study investigated the association between preconception PMDs and perinatal depression in a single tertiary care setting.</p><p><strong>Methods: </strong>We analyzed data from pregnant women who gave birth at Kyoto University Hospital between April 2020 and October 2023. The Premenstrual Symptoms Screening Tool was administered at the first postconception visit to retrospectively assess PMD status before the current pregnancy. The Edinburgh Postnatal Depression Scale (EPDS) was administered during pregnancy and one month postpartum as a prospective measure of perinatal depression. EPDS cutoff values were set at 12/13 during pregnancy and 8/9 at one month postpartum.</p><p><strong>Results: </strong>Of the 781 women analyzed, 53 had preconception PMD. Univariate and multivariate logistic regression analyses revealed that preconception PMD was associated with an EPDS score of ≥ 13 during pregnancy, with a crude odds ratio (OR) of 5.78 (95% confidence interval [CI]: 2.70-11.75) and an adjusted OR of 3.71 (95% CI: 1.54-8.35). For an EPDS score of ≥ 9 at 1 month postpartum, the crude OR was 3.36 (95% CI: 1.79-6.12) and the adjusted OR was 2.16 (95% CI: 1.04-4.35).</p><p><strong>Conclusions: </strong>Our findings indicate that preconception PMDs are a significant risk factor for both depression during pregnancy and postpartum depression. These results support the implementation of preconception PMD screening during antenatal checkups as a preventive measure and to identify women in need of early mental health care.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"18 1","pages":"24"},"PeriodicalIF":2.3,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychogenic fever and neurodevelopmental disorders among Japanese children.","authors":"Ayumi Okada, Yoshie Shigeyasu, Chikako Fujii, Chie Tanaka, Mana Hanzawa, Akiko Sugihara, Makiko Horiuchi, Hirokazu Tsukahara","doi":"10.1186/s13030-024-00322-8","DOIUrl":"10.1186/s13030-024-00322-8","url":null,"abstract":"<p><strong>Background: </strong>Psychosocial stress can induce various physical symptoms, including fever, which is a commonly seen symptom in pediatric practice. In cases of unexplained fever, psychogenic fever should be considered as a potential cause. Children with neurodevelopmental disorders may be more vulnerable to stress and therefore more prone to developing somatic symptoms than their peers. This study aimed to elucidate the characteristics of children with psychogenic fever and comorbidity.</p><p><strong>Methods: </strong>This study included 21 patients with psychogenic fever who visited the Department of Pediatric Psychosomatic Medicine, Okayama University Hospital. Information on age, sex, disease onset, final estimated diagnosis, comorbidities, treatment course, and outcome was obtained from the patients' medical records.</p><p><strong>Results: </strong>Of the 21 patients included, 7 were boys and 14 were girls, and their median age was 13.0 (range: 8.6-14.6) years. A total of 19 patients had no attendance at school, and all patients showed signs of maladjustment in school. The comorbidities included orthostatic dysregulation (n = 4) and migraine (n = 3). Neurodevelopmental disorders were observed in nine patients, eight of whom were diagnosed after the initial visit. The mean treatment duration was 37.2 months. The outcomes were complete remission (n = 9), improvement (n = 4), discontinuation (n = 1), and referral to another physician (n = 7).</p><p><strong>Conclusion: </strong>Various comorbidities were observed in the patients of this study with psychogenic fever, including the coexistence of neurodevelopmental disorders, such as autistic spectrum disorder. Children with neurodevelopmental disorders are prone to psychological stress resulting from difficulties in social adjustment. It is crucial to understand the developmental characteristics and environmental adaptation of patients to facilitate accurate diagnosis and treatment.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"18 1","pages":"23"},"PeriodicalIF":2.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Assessment of the renal function of patients with anorexia nervosa.","authors":"Hiroyuki Miyahara, Yoshie Shigeyasu, Chikako Fujii, Chie Tanaka, Mana Hanzawa, Akiko Sugihara, Ayumi Okada, Hirokazu Tsukahara","doi":"10.1186/s13030-024-00319-3","DOIUrl":"10.1186/s13030-024-00319-3","url":null,"abstract":"","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"18 1","pages":"22"},"PeriodicalIF":2.3,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining illness narratives in the context of the postoperative psychological state: A mixed-methods study of emotion-focused illness narrative.","authors":"Tünde Lévai, György Lázár, Erna Krajinovic, Iván Devosa, Melinda Látos","doi":"10.1186/s13030-024-00318-4","DOIUrl":"https://doi.org/10.1186/s13030-024-00318-4","url":null,"abstract":"","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"18 1","pages":"21"},"PeriodicalIF":2.3,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11470729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}