BioPsychoSocial Medicine最新文献

{"title":"Usability study to guide the development of a cognitive behavioral therapy mobile application for reducing irritable bowel syndrome symptoms.","authors":"Tadahiro Yamazaki, Ken Kurisu, Tomomi Machida, Mie Kunio, Yoshitaka Kanemitsu, Tadaatsu Hanadate, Shin Fukudo, Kazuhiro Yoshiuchi","doi":"10.1186/s13030-026-00354-2","DOIUrl":"10.1186/s13030-026-00354-2","url":null,"abstract":"<p><p>BACKGROUND: Irritable bowel syndrome (IBS) is a prevalent disorder of gut-brain interaction in which psychosocial factors can exacerbate symptoms. Although cognitive behavioral therapy (CBT) has proven effective in alleviating IBS symptoms, its widespread implementation is limited by therapist shortages and the substantial time demands placed on both patients and clinicians. Mobile health–delivered Just-in-Time Adaptive Interventions (JITAIs) may overcome these barriers by providing continuous, personalized support. In this study, we simulated the core functions of a JITAI-based CBT application via Google Forms and gathered feedback from patients and clinicians for application development. METHODS: In this three-month, multicenter observational study, ten adults meeting Rome IV criteria for IBS were enrolled from three psychosomatic clinics in Japan. Using Google Forms as a prototype, we delivered: a daily symptom diary, an exposure-therapy module with anxiety-hierarchy support and automated progression prompts, and an educational website. Usage data were recorded automatically, and feasibility, burden and satisfaction were assessed through post-study questionnaires with patients (n = 8) and semi-structured interviews with patients (n = 3) and physicians (n = 4). RESULTS: All ten participants (three women; mean age 28.4 years, range 18–52) completed the study (IBS with diarrhea [IBS-D] n = 6; IBS with constipation and diarrhea [IBS-M] n = 3; IBS unclassified [IBS-U] n = 1). Mean daily symptom diary completion rate was 94.9% (range 79.4–100%). A mean of 17.2 exposure sessions was recorded (range 2–53). In the usability questionnaire (n = 8/10), 6/8 (75%) agreed/strongly agreed that they wanted to continue the daily symptom diary, and 5/8 (62.5%) agreed/strongly agreed that they would recommend the prototype to others with IBS symptoms. The educational website was infrequently accessed. In patient interviews (n = 3), two participants who repeatedly practiced exposure reported perceiving declines in their Subjective Units of Distress over time, which encouraged continued practice. Interviews with physicians highlighted the need for an integrated mobile-application interface offering real-time visual feedback and streamlined hierarchy creation. CONCLUSIONS: High completion rates showed that smartphone self-tracking and exposure exercises were acceptable to patients with IBS. The future application should automate hierarchy building, embed educational content, and include participants with a broader range of IBS subtypes. Developing a dedicated JITAI application and conducting larger, controlled trials are needed to confirm clinical efficacy and long-term adherence. </p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxious Depressive Attack (ADA) -its prevalence and clinical implication.","authors":"Hisanobu Kaiya, Shota Noda, Satomi Matsumoto, Yojiro Sakai, Takeshi Otowa, Tsukasa Sasaki, Fusaka Minami","doi":"10.1186/s13030-026-00355-1","DOIUrl":"10.1186/s13030-026-00355-1","url":null,"abstract":"<p><p>BACKGROUND: Anxious-Depressive Attack (ADA) is one of the three types of anxiety attacks originally described by Freud. ADA is characterized by the sudden onset of intense anxiety, immediately followed by intrusive ruminations. These intrusive thoughts, often centered on past regrets or future worries, cause　significant psychological distress. Some individuals respond to these episodes with maladaptive or impulsive coping　behaviors. This study aimed to investigate the prevalence of ADA among new patients at an anxiety disorder specialty clinic and to examine the associated psychiatric and psychological characteristics. METHODS: New patients (N = 286) presenting to an anxiety disorder clinic in Tokyo were assessed for the presence of ADA independently by a psychiatrist and Certified Public Psychologists (Japan), based on predefined diagnostic criteria. Axis I and Axis II diagnoses were established using the Japanese version of the Mini-International Neuropsychiatric Interview (MINI) and the Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II), respectively. Histories of early separation or abuse were assessed using structured questionnaires. Psychological assessments of anxiety, depression, social anxiety, stress, and rejection sensitivity (RS) were conducted. Structural equation modeling (SEM) was performed to examine relationships among these variables. RESULTS: The lifetime prevalence of ADA was 21.68%. ADA was observed across 16 Axis I disorders and 6 Axis II personality disorders. Compared with patients without ADA, those with ADA exhibited significantly higher scores on all psychological measures. SEM demonstrated that both RS and depressive symptoms independently contributed to the occurrence of ADA. CONCLUSION: ADA was found across a wide range of psychiatric disorders characterized by heightened RS. These findings suggest that ADA may be associated with increased clinical complexity. Active screening for ADA in clinical practice may facilitate early identification and more appropriate intervention strategies. </p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13137476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Effects of irritable bowel syndrome and related cognitive-behavioral and occupational stress factors on the productivity and abdominal symptoms of Japanese workers: a longitudinal study.","authors":"Nagisa Sugaya, Shuhei Izawa, Takeshi Sasaki","doi":"10.1186/s13030-026-00356-0","DOIUrl":"10.1186/s13030-026-00356-0","url":null,"abstract":"","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"20 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13001296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric scurvy and eating disorders: the feasibility of a tasteless, odorless multiple-micronutrient powder for avoidance of tube feeding.","authors":"Tomoki Saito, Shogo Minamikawa, Sayaka Okazaki, Kazumi Tomioka, Mao Mizuta, Atsuro Saito, Yasuo Nakagishi","doi":"10.1186/s13030-026-00351-5","DOIUrl":"10.1186/s13030-026-00351-5","url":null,"abstract":"<p><p>BACKGROUND: Scurvy has re-emerged in association with neurodevelopmental and eating disorders, particularly selective eating. This study aimed to investigate the clinical characteristics of pediatric scurvy cases. METHODS: We retrospectively assessed the data of pediatric patients diagnosed with scurvy at a Japanese medical institution between 2017 and 2023. Clinical characteristics, nutritional profiles, and treatment outcomes were analyzed. RESULTS: In total, 13 children, median age 52 months, had scurvy, 92% of whom had confirmed or suspected autism spectrum disorder; all were diagnosed with an eating disorder. All children also had low serum vitamin C levels, and 85% exhibited multiple nutrient deficiencies. Common symptoms included gait disturbances (85%), joint pain (69%), and fever (46%). Eight patients (62%) were misdiagnosed by their previous doctor. In the acute phase, the median symptom resolution time was 10 days by administration of vitamin C. In the chronic phase, despite nutritional counseling and education, none of the patients were able to consume enough vitamin C by food, and the prescribed vitamin formulation was not taken in 4 of 9 patients (44%) owing to hypersensitivity. Treatment with odorless, tasteless, multiple-micronutrient supplements containing vitamin C was successful in all 11 patients who attempted it. CONCLUSIONS: All cases of pediatric scurvy in this cohort were caused by an eating disorder, neurodevelopmental disorder, physical disease, or a combination thereof. The diverse clinical course and misdiagnosis in some cases underscore the importance of a detailed dietary history for diagnosis. In terms of treatment, all patients in this study had very limited oral food owing to autism, but none required tube feeding, indicating that tasteless, odorless, multiple-micronutrient supplement powders might be beneficial in reducing the need for tube feeding in children who cannot take the prescribed vitamin formulation orally. </p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scoping review of the Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT) for use with liver transplant candidates.","authors":"Alberto Olivero, Marco Miniotti, Alessandro Godono, Paolo Leombruni","doi":"10.1186/s13030-026-00352-4","DOIUrl":"10.1186/s13030-026-00352-4","url":null,"abstract":"<p><p>BACKGROUND: Liver transplantation (LT) is a life-saving treatment for end-stage liver disease, and psychosocial factors significantly influence eligibility, adherence, and outcomes. The Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT) was developed to standardize psychosocial evaluation across four domains: treatment readiness, social support, psychopathology, and substance use. Despite its growing global adoption, evidence regarding its validity, predictive value, and applicability, specifically in LT, remains fragmented and heterogeneous. This scoping review maps and summarizes the available empirical evidence on SIPAT use in adult LT candidates. It focuses on (1) score distributions (2), psychosocial differences by disease etiology, and (3) associations with listing decisions, post-transplant outcomes, relapse risk, and quality of life. MAIN BODY: A systematic search of PubMed, Scopus, and PsycInfo (January 2012–May 2025) identified ten eligible empirical studies, primarily observational in design, with sample sizes ranging from 22 to 2,825 participants. Across studies, a substantial proportion of LT candidates were classified as having moderate-to-high psychosocial risk, frequently exceeding a SIPAT threshold of ≥ 21, although cutoff values varied across studies. Evidence from a limited number of investigations suggests that domains related to treatment readiness and lifestyle/substance use may be particularly affected in LT populations. Studies examining etiological subgroups reported higher SIPAT scores among candidates with alcohol-associated liver disease (ALD) or acute alcoholic hepatitis compared with non-ALD candidates, although findings were not uniform across all studies. Higher total SIPAT scores were associated in several cohorts with lower likelihood of listing and with adverse post-transplant outcomes, including nonadherence and acute rejection. In ALD samples, elevated SIPAT scores were associated with increased risk of harmful alcohol relapse, independent of abstinence duration. Notably, none of the included studies evaluated associations between SIPAT scores and post-transplant quality-of-life outcomes. CONCLUSION: Current evidence suggests that the SIPAT is a useful framework for structuring psychosocial assessment in liver transplantation and for identifying potentially modifiable vulnerabilities relevant to listing decisions and selected post-transplant outcomes. However, substantial methodological heterogeneity, inconsistent cutoff thresholds, and limited evidence across some outcome domains, particularly quality of life, constrain comparability and clinical generalizability. Future multicenter, prospective studies are needed to harmonize cutoff values, examine sensitivity to change, and clarify the role of SIPAT in predicting long-term patient-centered outcomes. </p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation-associated depression in cholangiocarcinoma: impacts of surgical resection and radiotherapy.","authors":"Tzu-Hsuan Sung, Yang-Chen Shen, Chia-Jui Yen, Yan-Shen Shan, Po See Chen","doi":"10.1186/s13030-026-00350-6","DOIUrl":"10.1186/s13030-026-00350-6","url":null,"abstract":"<p><p>BACKGROUND: Cholangiocarcinoma (CCA) is an aggressive malignancy associated with systemic inflammation and a high psychological burden. However, the relationship between inflammation and depression in CCA remains poorly understood. This study aimed to investigate the association between systemic inflammatory markers and depression in patients with CCA. METHODS: We conducted a prospective cohort study of patients aged ≥ 20 years with a diagnosis of cholangiocarcinoma treated at a single tertiary medical center between May 2021 and September 2024. Depression was evaluated using the Patient Health Questionnaire-9. Generalized linear mixed models were applied to examine the relationships between inflammatory markers and depression. RESULTS: A total of 164 patients with CCA were included, comprising 97 intrahepatic cholangiocarcinoma (ICC) and 67 extrahepatic cholangiocarcinoma (ECC) cases. Depression prevalence was 19.9% at baseline and fluctuated over time, ultimately decreasing to 10.4% at 12 months. In multivariate analyses, not receiving surgical resection and higher C-reactive protein (CRP) levels were independently associated with depression in the overall CCA cohort and in the ICC subgroup. In the ECC subgroup, receipt of radiotherapy and lower albumin levels were independently associated with increased depression risk. CONCLUSIONS: Our study reveals a significant association between inflammatory markers and depression in CCA patients, with CRP emerging as a key marker. Notably, surgical intervention was associated with a reduced risk of depression, whereas radiotherapy in ECC patients was associated with an increased risk of depression. </p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":" ","pages":"3"},"PeriodicalIF":2.1,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12896193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146091949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of irritable bowel syndrome and related cognitive-behavioral and occupational stress factors on the productivity and abdominal symptoms of Japanese workers: a longitudinal study.","authors":"Nagisa Sugaya, Shuhei Izawa, Takeshi Sasaki","doi":"10.1186/s13030-026-00349-z","DOIUrl":"10.1186/s13030-026-00349-z","url":null,"abstract":"<p><p>OBJECTIVES: This longitudinal study aimed to examine the effects of irritable bowel syndrome (IBS) and related cognitive-behavioral and occupational stress factors on the productivity and abdominal symptoms of Japanese workers. METHODS: An online survey was conducted from October 5 to October 20, 2023 (Time 1), targeting workers aged 20–49 years who were not self-employed or business owners and who worked more than 30 h per week. Data from 1,062 participants was available. A follow-up survey was conducted one year later (Time 2), with responses from 424 participants (161 women and 114 persons who reported IBS in the Time 1 screening) used for the analysis. RESULTS: Hierarchical multiple regression analysis showed that depression, physical symptoms, and the presence of IBS at Time 1 had significant effects on presenteeism and overall work productivity impairment at Time 2. In the IBS group, the interaction between maladaptive cognition related to IBS and job control at Time 1 were significantly related to abdominal symptoms at Time 2, indicating that IBS symptoms were more severe when job control was low and maladaptive cognition related to IBS was high, although the simple slope test results did not reach statistical significance. The physical symptoms of the IBS group at Time 1 had significant effects on presenteeism and overall work productivity impairment at Time 2; however, occupational stress factors and IBS-related cognitive-behavioral variables did not show significant effects. CONCLUSION: The presence of IBS was shown to be related to the magnitude of productivity impairment one year later. Additionally, a correlation was seen between job control and maladaptive cognition regarding the effect of IBS on abdominal symptoms up to one year later. However, no evidence was found that occupational stress factors or IBS-related cognitive-behavioral variables were related to work productivity one year later. </p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":" ","pages":"2"},"PeriodicalIF":2.1,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12874941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological evaluation of the emotional regulation of patients with hereditary angioedema.","authors":"Laurent Sparrow, Christelle Duprez, Louise Richez, Michel Raguet, Louis Terriou, Isabelle Citerne, Sébastien Sanges, Launay David","doi":"10.1186/s13030-025-00348-6","DOIUrl":"10.1186/s13030-025-00348-6","url":null,"abstract":"<p><p>OBJECTIVE: Hereditary angioedema (HAE) is a rare disease that presents with recurrent attacks that can be triggered by stress or other emotions. The emotional impact of HAE is well-documented, although mainly via self-reported questionnaires. In this study, we used physiological measures to investigate stress regulation in patients with HAE and compared them to patients with immune thrombocytopenia (ITP), a disease that also progresses with attacks but without emotional triggers. METHODS: Twenty-six adult patients with HAE or ITP (13 each) were included in the study. Patients were asked to perform several computerized tasks that activated different branches of the autonomic nervous system (ANS). Heart rate variability and electrodermal activity were measured during the experimental tasks and a medical consultation that followed the experiments. RESULTS: Patients with HAE did not differ from patients with ITP in their physiological responses. In the reactivity tasks, a non-significant correlation significance was observed between reaction times (RTs) and peak spread in the HAE and ITP groups only for male patients and in a different way for HAE (negative correlation) and ITP (positive correlation). During medical consultations, an association between the physician’s perception of the patient’s stress and the patient’s physiological measures of stress was found only in female HAE patients, but without significance. CONCLUSIONS: The ANS of patients with HAE and ITP was similarly and abnormally activated, with a possible effect by sex. These results shed new light on the role of emotional regulation in chronic diseases. TRIAL REGISTRATION: This article does not report the results of a health care intervention on human participants. The research was not preregistered in any registry. The analysis plan was not preregistered in an independent, institutional registry. Data, analytic methods, and study materials are not made directly available. </p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"20 1","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12777275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145910475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Communicative and critical health literacy and eating behaviors in Japanese adults predominantly over 40: the modifying role of body image distortion.","authors":"Noriaki Kurita, Takako Maeshibu, Sayaka Shimizu, Tetsuro Aita, Takafumi Wakita, Hiroe Kikuchi","doi":"10.1186/s13030-025-00347-7","DOIUrl":"10.1186/s13030-025-00347-7","url":null,"abstract":"<p><strong>Background: </strong>Disordered eating behaviors, emotional eating (EE), uncontrolled eating (UE), and cognitive restraint (CR) contribute to weight dysregulation and remain public health concerns in Japan. Body image distortion (BID), or the misperception of one's body size, has been linked to both being underweight and overweight. While health literacy (HL) and BID are individually associated with eating behaviors, the influence of higher-order HL domains-communicative and critical literacy-and their interactions with BID remain unclear. This study examined how HL and BID jointly influence multidimensional eating behaviors.</p><p><strong>Methods: </strong>In this cross-sectional study of Japanese adults, HL was measured using the 14-item Health Literacy Scale. BID was defined as the discrepancy between the perceived (via the Figure Rating Scale) and actual body size (via BMI) and categorized as underestimation, no distortion, or overestimation. Eating behaviors (UE, EE, and CR) were assessed using the Japanese version of the 18-item Three-Factor Eating Questionnaire-R18V2. Multinomial logistic regression was used to examine the association between HL and BID, and general linear models were used to test whether BID moderated the effects of higher-order HL domains on eating behavior.</p><p><strong>Results: </strong>Among the participants, 13.0% were underweight, 60.2% had a normal weight, 18.7% were overweight, and 8.0% were obese. BID was categorized as overestimation (36.7%), non-distortion (53.6%), or underestimation (9.7%). HL scores were not significantly associated with overestimation or underestimation; however, a higher BMI was inversely related to overestimation. Higher functional HL was associated with lower EE, UE, and CR across all BID subgroups. However, associations for communicative HL varied by BID (interaction P = 0.002 for EE, 0.070 for CR); it was positively associated with EE and CR in the underestimated group, but inversely associated with EE in the overestimated group. Critical HL was positively associated with CR in the overestimation group (interaction, P = 0.015).</p><p><strong>Conclusion: </strong>Fostering functional HL may support healthier eating behaviors, regardless of BID. Communicative HL may be beneficial for individuals with overestimation-type BID, but potentially counterproductive for those with underestimation. Critical HL appears to encourage more restrictive eating, specifically among individuals with overestimated HL.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"19 1","pages":"26"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12667047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145647267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived social support and psychological resilience as mediators between social frailty and the frailty of older patients with heart failure: a cross-sectional study.","authors":"Junting Huang, Xiaobo Liu, Duolao Wang, Xiaorong Luan, Wanxia Yao, Zhengzhou Chen","doi":"10.1186/s13030-025-00345-9","DOIUrl":"https://doi.org/10.1186/s13030-025-00345-9","url":null,"abstract":"<p><strong>Objective: </strong>This study explores the level of frailty and the factors that influence elderly HF inpatients. It also examines the correlation between social frailty, perceived social support, and psychological resilience. It verifies psychological resilience and perceived social support as mediators between social frailty and frailty.</p><p><strong>Method: </strong>This cross-sectional study collected four hundred fifty-six questionnaires from Northeast China, Northwest China and South China. The research assessment tools include the FRAIL scale (frailty), MSPSS scale (perceived social support), CD-RISC10 (psychological resilience), and HALFT scale (social frailty). Data analysis was performed using multiple regression analysis and the SPSS PROCESS Macro plug-in Model 6 and Model 4.</p><p><strong>Results: </strong>Female (β = 0.085, p = 0.036), number of hospitalizations (β = 0.342, p < 0.001), and NYHA class (β = 0.325, p = 0.004) were risk factors for frailty in elderly HF inpatients. Frailty was found to be at a medium-high level, negatively correlated with perceived social support (ρ=-0.471, p < 0.01) and psychological resilience (ρ=-0.670, p < 0.01), and positively correlated with social frailty (ρ = 0.596, p < 0.01). Psychological resilience and perceived social support mediated the relation between social frailty and frailty, with an indirect effect of 27.18%, 10.49%, and 24.19%, respectively, all partial mediation.</p><p><strong>Conclusion: </strong>NYHA class, number of hospitalizations, and female sex are indicators of the frailty level of elderly HF patients. Social frailty, psychological resilience, and perceived social support are interrelated. Psychological resilience and perceived social support are mediators in the relation between social frailty and frailty.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"19 1","pages":"25"},"PeriodicalIF":2.4,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12661870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145629176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}