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Oral administration of 6-methylsulfinylhexyl isothiocyanate extracted from wasabi is safe and improves the fatigue and sleep of healthy volunteers. 口服从山葵中提取的6-甲基亚砜基己基异硫氰酸酯是安全的,可以改善健康志愿者的疲劳和睡眠。
IF 2.1 4区 医学
BioPsychoSocial Medicine Pub Date : 2023-08-23 DOI: 10.1186/s13030-023-00287-0
Ryota Nakajima, Masanobu Kanou, Masahiko Tokushima, Yoshitaka Iwama, Kei Yamana
{"title":"Oral administration of 6-methylsulfinylhexyl isothiocyanate extracted from wasabi is safe and improves the fatigue and sleep of healthy volunteers.","authors":"Ryota Nakajima, Masanobu Kanou, Masahiko Tokushima, Yoshitaka Iwama, Kei Yamana","doi":"10.1186/s13030-023-00287-0","DOIUrl":"10.1186/s13030-023-00287-0","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to conduct a preliminary evaluation of the effects of 6-methylsulfinylhexyl isothiocyanate (6-MSITC) contained in wasabi rhizomes on fatigue and sleep and to examine its safety through overdose study.</p><p><strong>Methods: </strong>A total of 20 healthy volunteers who were experiencing daily fatigue were given powder containing 6-MSITC (4.8 mg/day of 6-MSITC) extracted from wasabi for 4 weeks. Then, fatigue, sleep, autonomic nervous functioning, stress, and immunity were evaluated. In addition, an overdose safety study of the extract powder (up to 16 mg/day of 6-MSITC for 4 weeks) was performed with 30 healthy volunteers in a double-blind, placebo-controlled method.</p><p><strong>Results: </strong>The powder containing 6-MSITC did not improve fatigue after a mental task, but fatigue before the mental task, sleep, and mood were improved significantly after 4 weeks intake. No changes were observed in the autonomic nerve function, stress, or immune markers. In the overdose safety study, no changes in the parameters ​​or side effects were observed, and the results showed that high doses of the extract powder containing 6-MSITC is safe.</p><p><strong>Conclusion: </strong>This study confirmed the possibility that this powder extracted from wasabi that contains 6-MSITC might improve fatigue and sleep. However, because the effectiveness evaluation in this study was a single-arm, open-label study and there was no placebo control group, these points must be considered when interpreting the results. Safety was confirmed in an overdose study of more than three times the amount compared to that in the efficacy evaluation study. In the future, further research should be conducted on its effectiveness for treating fatigue and sleep problems.</p><p><strong>Trial registration: </strong>UMIN clinical trial registration system, UMIN000049913. Registered 27 December 2022 Retrospectively registered, https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000056818.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"17 1","pages":"30"},"PeriodicalIF":2.1,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10473863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Trends in the effect of COVID-19 on consultations for persons with clinical and subclinical eating disorders. COVID-19对临床和亚临床饮食失调患者咨询影响的趋势
IF 2.1 4区 医学
BioPsychoSocial Medicine Pub Date : 2023-08-09 DOI: 10.1186/s13030-023-00285-2
Keisuke Kawai, Hisateru Tachimori, Yurie Yamamoto, Yuki Nakatani, Shinmi Iwasaki, Atsushi Sekiguchi, Yoshiharu Kim, Naho Tamura
{"title":"Trends in the effect of COVID-19 on consultations for persons with clinical and subclinical eating disorders.","authors":"Keisuke Kawai, Hisateru Tachimori, Yurie Yamamoto, Yuki Nakatani, Shinmi Iwasaki, Atsushi Sekiguchi, Yoshiharu Kim, Naho Tamura","doi":"10.1186/s13030-023-00285-2","DOIUrl":"10.1186/s13030-023-00285-2","url":null,"abstract":"<p><strong>Background: </strong>The coronavirus disease 2019 (COVID-19) pandemic has increased the risk of individuals developing eating disorders and has exacerbated existing eating disorders. This observational study investigated the impact of the COVID-19 pandemic on patients with clinical and subclinical eating disorders.</p><p><strong>Methods: </strong>This study was conducted over a period of four years: two years before and after the onset of the COVID-19 pandemic in Japan. We recorded the number and types of consultations provided by the Eating Disorder Treatment and Support Center coordinator. For subgroup analysis, data were classified by age, body mass index, and source of consultation, including patients, families, and personnel. The Seasonal Decomposition of Time Series by Loess was used for time series analysis.</p><p><strong>Results: </strong>The total number of consultations increased after the start of the pandemic and peaked around the beginning of 2022, before subsequently falling despite the increase in the number of COVID-19 infections. A similar trend was observed in patients aged 10-29 years. The study period coincided with social isolation and school/college/university closures.</p><p><strong>Conclusions: </strong>The number of eating disorder consultations increased after the start of the pandemic. Although COVID-19 infections persisted, the pandemic's impact was transient.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"17 1","pages":"29"},"PeriodicalIF":2.1,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9972738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Physical exercise augmented cognitive behaviour therapy for older adults with generalised anxiety disorder (PEXACOG): a feasibility study for a randomized controlled trial. 更正:体育锻炼增强认知行为治疗老年人广泛性焦虑症(PEXACOG):一项随机对照试验的可行性研究。
IF 2.1 4区 医学
BioPsychoSocial Medicine Pub Date : 2023-08-04 DOI: 10.1186/s13030-023-00284-3
Kristine Sirevåg, S H Stavestrand, T Sjøbø, T B Endal, H M Nordahl, E Andersson, I H Nordhus, Å Rekdal, K Specht, Å Hammar, A Halmøy, J Mohlman, H Hjelmervik, J F Thayer, A Hovland
{"title":"Correction to: Physical exercise augmented cognitive behaviour therapy for older adults with generalised anxiety disorder (PEXACOG): a feasibility study for a randomized controlled trial.","authors":"Kristine Sirevåg, S H Stavestrand, T Sjøbø, T B Endal, H M Nordahl, E Andersson, I H Nordhus, Å Rekdal, K Specht, Å Hammar, A Halmøy, J Mohlman, H Hjelmervik, J F Thayer, A Hovland","doi":"10.1186/s13030-023-00284-3","DOIUrl":"10.1186/s13030-023-00284-3","url":null,"abstract":"","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"17 1","pages":"28"},"PeriodicalIF":2.1,"publicationDate":"2023-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9943378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of a training program for a patient with non-cardiac chest pain that combines intervention to improve quality of life, psychological state, and functional capacity: a case report. 一项针对非心源性胸痛患者的训练计划,结合干预措施改善生活质量、心理状态和功能能力的有效性:一份病例报告。
IF 2.1 4区 医学
BioPsychoSocial Medicine Pub Date : 2023-07-26 DOI: 10.1186/s13030-023-00283-4
Irem Huzmeli, Aysel Yildiz Ozer
{"title":"Effectiveness of a training program for a patient with non-cardiac chest pain that combines intervention to improve quality of life, psychological state, and functional capacity: a case report.","authors":"Irem Huzmeli,&nbsp;Aysel Yildiz Ozer","doi":"10.1186/s13030-023-00283-4","DOIUrl":"https://doi.org/10.1186/s13030-023-00283-4","url":null,"abstract":"<p><strong>Background: </strong>Noncardiac chest pain (NCCP) is persistent angina-like chest pain without cardiac origin that affects the patient's health related quality of life (HrQoL), although it does not affect mortality. The effect of a comprehensive training program for NCCP focused on quality of life, psychological state, peripheral muscle strength, physical activity, and quality of life has not been previously established or published. Therefore, this study aimed to show the effectiveness of our combined training program that focuses on functional capacity, physical activity, pulmonary function, respiratory and peripheral muscle strength, dyspnea, fatigue, anxiety, and depression perception in NCCP patients with dyspnea.</p><p><strong>Case presentation: </strong>A 38-year-old man with shortness of breath and NCCP was referred to to us for cardiopulmonary rehabilitation. Respiratory muscle strength (mouth pressure device), functional capacity (6 min walking test, 6-MWT), peripheral muscle strength (dynamometer), pulmonary function (spirometry), fatigue (fatigue severity scale), shortness of breath (MMRC, Modified Medical Council Research, Modified Borg Scale-MBS), physical activity (International Physical Activity Questionnaire, IPAQ), health related quality of life (SF-36, Short Form-36), and depression and anxiety (Hospital Depression and Anxiety scale, HADs) were assessed. Aerobic training combined with inspiratory muscle training (loading 30% maximal inspiratory pressure (MIP)) was administered at least 5 days/week for 6 weeks. Functional capacity, physical activity, pulmonary function, and respiratory and peripheral muscle strength improved, and dyspnea, fatigue, anxiety, and depression perception were decreased after the management.</p><p><strong>Conclusions: </strong>This combined training program was effective for patients with NCCP and shortness of breath. Future studies should be conducted to find the most effective biopsychosocial training protocol for NCCP patients.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"17 1","pages":"27"},"PeriodicalIF":2.1,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10263190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroticism mediates the association between childhood abuse and the well-being of community dwelling adult volunteers. 神经质在儿童期虐待与社区成年志愿者幸福感之间起中介作用。
IF 2.1 4区 医学
BioPsychoSocial Medicine Pub Date : 2023-07-24 DOI: 10.1186/s13030-023-00282-5
Yota Fujimura, Akiyoshi Shimura, Chihiro Morishita, Yu Tamada, Hajime Tanabe, Ichiro Kusumi, Takeshi Inoue
{"title":"Neuroticism mediates the association between childhood abuse and the well-being of community dwelling adult volunteers.","authors":"Yota Fujimura,&nbsp;Akiyoshi Shimura,&nbsp;Chihiro Morishita,&nbsp;Yu Tamada,&nbsp;Hajime Tanabe,&nbsp;Ichiro Kusumi,&nbsp;Takeshi Inoue","doi":"10.1186/s13030-023-00282-5","DOIUrl":"https://doi.org/10.1186/s13030-023-00282-5","url":null,"abstract":"<p><strong>Background: </strong>Previous studies reported that the experience of maltreatment in childhood reduces subjective well-being in adulthood and that neuroticism is negatively associated with subjective well-being. However, the interrelationship between childhood maltreatment, adult life events, neuroticism, and subjective well-being has not been analyzed to date.</p><p><strong>Methods: </strong>A total of 404 adult volunteers provided responses to the following questionnaires: 1) Childhood Abuse and Trauma Scale, 2) Life Experiences Survey, 3) Neuroticism Subscale of the Shortened Eysenck Personality Questionnaire-Revised, and 4) Subjective Well-Being Inventory. The path model was used to analyze possible interrelationships among these parameters.</p><p><strong>Results: </strong>The effect of childhood abuse on subjective well-being was indirect and was mediated by neuroticism. The effect of neuroticism on the negative, but not positive, change score on the Life Experiences Survey was significant. The indirect effect of neuroticism on subjective well-being was not significant via either negative or positive change scores.</p><p><strong>Conclusions: </strong>This study demonstrated that age, subjective social status, neuroticism, and negative and positive life events were significantly associated with subjective well-being. Furthermore, using path analysis, we demonstrated the mediating role of neuroticism in the indirect effect of childhood abuse on subjective well-being.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"17 1","pages":"26"},"PeriodicalIF":2.1,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10364364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9924177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physical exercise augmented cognitive behaviour therapy for older adults with generalised anxiety disorder (PEXACOG): a feasibility study for a randomized controlled trial. 体育锻炼增强认知行为治疗老年人广泛性焦虑症(PEXACOG):一项随机对照试验的可行性研究
IF 2.1 4区 医学
BioPsychoSocial Medicine Pub Date : 2023-07-19 DOI: 10.1186/s13030-023-00280-7
Kristine Sirevåg, S H Stavestrand, T Sjøbø, T B Endal, H M Nordahl, E Andersson, I H Nordhus, Å Rekdal, K Specht, Å Hammar, A Halmøy, J Mohlman, H Hjelmervik, J F Thayer, A Hovland
{"title":"Physical exercise augmented cognitive behaviour therapy for older adults with generalised anxiety disorder (PEXACOG): a feasibility study for a randomized controlled trial.","authors":"Kristine Sirevåg, S H Stavestrand, T Sjøbø, T B Endal, H M Nordahl, E Andersson, I H Nordhus, Å Rekdal, K Specht, Å Hammar, A Halmøy, J Mohlman, H Hjelmervik, J F Thayer, A Hovland","doi":"10.1186/s13030-023-00280-7","DOIUrl":"10.1186/s13030-023-00280-7","url":null,"abstract":"<p><strong>Background: </strong>Generalised anxiety disorder (GAD) is a frequent and severe disorder among older adults. For older adults with GAD the effect of the recommended treatment, cognitive behaviour therapy (CBT), is reduced. Physical exercise (PE) may enhance the effect of CBT by improving cognitive function and increasing levels of brain-derived neurotrophic factor (BDNF), a predictor of the effect of CBT in patients with anxiety. The aim of the study was to assess the feasibility of a randomized controlled trial (RCT) investigating treatment effect of the combination of CBT and PE for GAD in a sample of older adults, including procedures for assessment and treatment.</p><p><strong>Methods: </strong>Four participants aged 62-70 years (M = 65.5, SD = 3.2) with a primary diagnosis of GAD were included. Participants received 15 weeks of PE in combination with 10 weeks of CBT. Participants completed self-report measures, and clinical, biological, physiological and neuropsychological tests at pre-, interim- and post-treatment.</p><p><strong>Results: </strong>Procedures, protocols, and results are presented. One participant dropped out during treatment. For the three participants completing, the total adherence to PE and CBT was 80% and 100%, respectively. An independent assessor concluded that the completers no longer fulfilled the criteria for GAD after treatment. Changes in self-report measures suggest symptom reduction related to anxiety and worry. The sample is considered representative for the target population.</p><p><strong>Conclusions: </strong>The results indicate that combining CBT and PE for older adults with GAD is feasible, and that the procedures and tests are suitable and manageable for the current sample.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov, NCT02690441. Registered on 24 February 2016, https://clinicaltrials.gov/ct2/show/NCT02690441 .</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"17 1","pages":"25"},"PeriodicalIF":2.1,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9998527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Characterization of the stanford integrated psychosocial assessment for transplant for heart, liver, and kidney transplant candidates in Japan. 日本心脏、肝脏和肾脏移植候选人的斯坦福综合社会心理评估的特征。
IF 2.1 4区 医学
BioPsychoSocial Medicine Pub Date : 2023-07-17 DOI: 10.1186/s13030-023-00281-6
Kosuke Takano, Hidehiro Oshibuchi, Sayaka Kobayashi, Junko Tsutsui, Satoko Ito, Rumiko Kamba, Rie Akaho, Katsuji Nishimura
{"title":"Characterization of the stanford integrated psychosocial assessment for transplant for heart, liver, and kidney transplant candidates in Japan.","authors":"Kosuke Takano,&nbsp;Hidehiro Oshibuchi,&nbsp;Sayaka Kobayashi,&nbsp;Junko Tsutsui,&nbsp;Satoko Ito,&nbsp;Rumiko Kamba,&nbsp;Rie Akaho,&nbsp;Katsuji Nishimura","doi":"10.1186/s13030-023-00281-6","DOIUrl":"https://doi.org/10.1186/s13030-023-00281-6","url":null,"abstract":"<p><strong>Background: </strong>The Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT) is a comprehensive psychosocial assessment proven useful for predicting the outcomes of organ transplantation that is expected to be useful in Japan. However, the characteristics of organ-specific SIPAT scores for organ transplant recipient candidates in Japan are unclear and, to date, the SIPAT has not been properly utilized in clinical practice. The purpose of this study was to present basic data that can be used to establish the relation between SIPAT scores and post-transplantation psychosocial outcomes as well as organ-specific outcomes.</p><p><strong>Methods: </strong>This study included 167 transplant recipient candidates (25 heart, 71 liver, and 71 kidney) who completed a semi-structured interview based on the Japanese version of SIPAT (SIPAT-J) prior to transplantation. The differences between organs in terms of SIPAT scores and differences in SIPAT scores based on demographic data were comparatively analyzed.</p><p><strong>Results: </strong>The total SIPAT scores were higher for liver recipient candidates than for heart recipient candidates (P = .019). Regarding the subscales, SIPAT B (social support system) scores were higher for liver and kidney recipient candidates than for heart recipient candidates (P = .021), whereas SIPAT C (psychological stability and psychopathology) scores were higher for liver recipient candidates than for kidney recipient candidates (P = .002). Recipient candidates with a history of psychiatric treatment and those who were unemployed had higher SIPAT scores, regardless of the transplant organ, than recipient candidates without a history of psychiatric treatment and those who were employed (P < .001, P = .016, respectively).</p><p><strong>Conclusions: </strong>There were notable differences in the total SIPAT-J and subscale scores among the liver, heart, and kidney recipient candidates. Each organ was associated with specific psychosocial issues that should be addressed before transplantation. Interventions such as information provision and patient education based on SIPAT assessment results for each organ may improve recipient post-transplant outcomes.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"17 1","pages":"24"},"PeriodicalIF":2.1,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9891110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Quality of life and physical/psychosocial factors in children and adolescents with orthostatic intolerance. 儿童和青少年站立不耐受的生活质量和身体/心理社会因素。
IF 2.1 4区 医学
BioPsychoSocial Medicine Pub Date : 2023-06-12 DOI: 10.1186/s13030-023-00278-1
Yoshie Shigeyasu, Ayumi Okada, Chikako Fujii, Chie Tanaka, Akiko Sugihara, Makiko Horiuchi, Takashi Yorifuji, Hirokazu Tsukahara
{"title":"Quality of life and physical/psychosocial factors in children and adolescents with orthostatic intolerance.","authors":"Yoshie Shigeyasu,&nbsp;Ayumi Okada,&nbsp;Chikako Fujii,&nbsp;Chie Tanaka,&nbsp;Akiko Sugihara,&nbsp;Makiko Horiuchi,&nbsp;Takashi Yorifuji,&nbsp;Hirokazu Tsukahara","doi":"10.1186/s13030-023-00278-1","DOIUrl":"https://doi.org/10.1186/s13030-023-00278-1","url":null,"abstract":"<p><strong>Background: </strong>Orthostatic intolerance (OI), which is common in children and adolescents, negatively impacts their quality of life (QOL) due to physical symptoms that limit work, school, and daily activities. The purpose of this study is to explore the association of physical and psychosocial factors with QOL scores in children and adolescents with OI.</p><p><strong>Methods: </strong>A cross sectional observational study was conducted. The study participants included 95 Japanese pediatric patients of age 9-15 years who were diagnosed with OI from April 2010 to March 2020. The QOL scores and the QOL T-scores of children with OI assessed using the KINDL-R questionnaire at the initial visit were compared with conventional normative data. The associations of physical and psychosocial factors with the QOL T-scores were examined using multiple linear regression.</p><p><strong>Results: </strong>Pediatric patients with OI had significantly lower QOL scores than healthy children in both elementary (50.7 ± 13.5 vs. 67.9 ± 13.4, p < 0.001) and junior high schools (51.8 ± 14.6 vs. 61.3 ± 12.6, p < 0.001). This finding was observed in the physical, mental, self-esteem, friends, and school domains. Total QOL scores were significantly associated with school nonattendance (β =  - 3.2, 95% confidence interval [CI] =  - 5.8 to - 0.5, p = 0.022) and poor relationship with school (β =  - 5.0, 95% CI =  - 9.8 to - 0.4, p = 0.035).</p><p><strong>Conclusions: </strong>These results suggest that the assessment of QOL, including both physical and psychosocial aspects, especially school factors, needs to be implemented earlier in children and adolescents with OI.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"17 1","pages":"23"},"PeriodicalIF":2.1,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10258988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9635169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systematic review and meta-analysis of calculating degree of comorbidity of irritable bowel syndrome with migraine. 肠易激综合征与偏头痛共病程度计算的系统回顾和meta分析。
IF 2.1 4区 医学
BioPsychoSocial Medicine Pub Date : 2023-06-08 DOI: 10.1186/s13030-023-00275-4
Tatvan S Todor, Shin Fukudo
{"title":"Systematic review and meta-analysis of calculating degree of comorbidity of irritable bowel syndrome with migraine.","authors":"Tatvan S Todor,&nbsp;Shin Fukudo","doi":"10.1186/s13030-023-00275-4","DOIUrl":"https://doi.org/10.1186/s13030-023-00275-4","url":null,"abstract":"<p><strong>Background: </strong>Irritable bowel syndrome (IBS) and migraines are often comorbid each other. These disorders are likely to be bidirectionally linked through the gut-brain axis and share several underlying mechanisms including central nervous system sensitization. However, quantitative analysis of comorbidity was not reported enough. The aim of this systematic review and meta-analysis was to calculate the present degree of comorbidity of these two disorders.</p><p><strong>Methods: </strong>A literature search was performed searching for articles describing IBS or migraine patients with the same inverse comorbidity. Pooled odds ratios (ORs) or hazard ratios (HRs) with 95% confidence intervals (CIs) were then extracted. The total effect estimates were determined and presented by random effect forest plots for the group of articles with IBS patients with migraine and the group of articles on migraine sufferers with comorbid IBS separately. The average results of these plots were compared.</p><p><strong>Results: </strong>The literature search resulted in initial 358 articles and final 22 articles for the meta-analysis. The total OR values obtained were 2.09 [1.79 - 2.43] in IBS with comorbid migraine or headache, 2.51 [1.76 - 3.58] for migraineurs with comorbid IBS and an overall HR of 1 .62 [1.29 - 2.03] was found for cohort studies of migraine sufferers with comorbid IBS. A similar expression of a selection of other comorbidities was found in IBS and migraine patients, especially for depression and fibromyalgia a strong similarity was found in their expression rate.</p><p><strong>Conclusions: </strong>This systematic review with meta-analysis was the first to combine data on IBS patients with comorbid migraine and migraineurs with comorbid IBS. The fact that closely related existential rates were observed between these two groups should be used as motivation for future research to further investigate these disorders for why this similarity occurs. Mechanisms involved in central hypersensitivity such as genetic risk factors, mitochondrial dysfunction and microbiota are particularly good candidates. Experimental designs in which therapeutic methods for these conditions can be exchanged or combined may also lead to the discovery of more efficient treatment methods.</p>","PeriodicalId":9027,"journal":{"name":"BioPsychoSocial Medicine","volume":"17 1","pages":"22"},"PeriodicalIF":2.1,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9608593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A nationwide questionnaire survey of physicians regarding the impact of the COVID-19 pandemic on patients and treatment system of psychosomatic medicine. 对全国医师进行新冠肺炎疫情对患者及心身医学治疗体系影响的问卷调查。
IF 2.1 4区 医学
BioPsychoSocial Medicine Pub Date : 2023-06-08 DOI: 10.1186/s13030-023-00279-0
Yukari Yamanaka, Kazuhiro Yoshiuchi, Chiharu Kubo, Shin Fukudo
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