Physical exercise augmented cognitive behaviour therapy for older adults with generalised anxiety disorder (PEXACOG): a feasibility study for a randomized controlled trial.

IF 2.3 4区 医学 Q2 PSYCHIATRY
Kristine Sirevåg, S H Stavestrand, T Sjøbø, T B Endal, H M Nordahl, E Andersson, I H Nordhus, Å Rekdal, K Specht, Å Hammar, A Halmøy, J Mohlman, H Hjelmervik, J F Thayer, A Hovland
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引用次数: 1

Abstract

Background: Generalised anxiety disorder (GAD) is a frequent and severe disorder among older adults. For older adults with GAD the effect of the recommended treatment, cognitive behaviour therapy (CBT), is reduced. Physical exercise (PE) may enhance the effect of CBT by improving cognitive function and increasing levels of brain-derived neurotrophic factor (BDNF), a predictor of the effect of CBT in patients with anxiety. The aim of the study was to assess the feasibility of a randomized controlled trial (RCT) investigating treatment effect of the combination of CBT and PE for GAD in a sample of older adults, including procedures for assessment and treatment.

Methods: Four participants aged 62-70 years (M = 65.5, SD = 3.2) with a primary diagnosis of GAD were included. Participants received 15 weeks of PE in combination with 10 weeks of CBT. Participants completed self-report measures, and clinical, biological, physiological and neuropsychological tests at pre-, interim- and post-treatment.

Results: Procedures, protocols, and results are presented. One participant dropped out during treatment. For the three participants completing, the total adherence to PE and CBT was 80% and 100%, respectively. An independent assessor concluded that the completers no longer fulfilled the criteria for GAD after treatment. Changes in self-report measures suggest symptom reduction related to anxiety and worry. The sample is considered representative for the target population.

Conclusions: The results indicate that combining CBT and PE for older adults with GAD is feasible, and that the procedures and tests are suitable and manageable for the current sample.

Trial registration: ClinicalTrials.gov, NCT02690441. Registered on 24 February 2016, https://clinicaltrials.gov/ct2/show/NCT02690441 .

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体育锻炼增强认知行为治疗老年人广泛性焦虑症(PEXACOG):一项随机对照试验的可行性研究
背景:广泛性焦虑症(GAD)是老年人中一种常见且严重的疾病。对于患有广泛性焦虑症的老年人,推荐的认知行为疗法(CBT)的效果会降低。体育锻炼(PE)可能通过改善认知功能和增加脑源性神经营养因子(BDNF)水平来增强CBT的效果,BDNF是CBT对焦虑患者效果的预测因子。该研究的目的是评估一项随机对照试验(RCT)的可行性,该试验调查了CBT和PE联合治疗老年人广泛性焦虑症的效果,包括评估和治疗程序。方法:纳入4例年龄在62 ~ 70岁之间,初始诊断为广泛性焦虑症的患者(M = 65.5, SD = 3.2)。参与者接受了15周的体育锻炼和10周的CBT治疗。参与者在治疗前、中期和治疗后完成了自我报告测量,以及临床、生物、生理和神经心理测试。结果:介绍了程序、方案和结果。一名参与者在治疗期间退出。对于完成的三名参与者,PE和CBT的总依从性分别为80%和100%。一个独立的评估者得出结论,完成者在治疗后不再符合广泛性焦虑症的标准。自我报告测量的变化表明焦虑和担忧相关的症状减轻。样本被认为是目标人群的代表。结论:结果表明CBT和PE联合治疗老年广泛性焦虑症是可行的,并且程序和测试对于当前样本是合适的和可管理的。试验注册:ClinicalTrials.gov, NCT02690441。2016年2月24日注册,网址:https://clinicaltrials.gov/ct2/show/NCT02690441。
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来源期刊
CiteScore
3.60
自引率
0.00%
发文量
23
审稿时长
18 weeks
期刊介绍: BioPsychoSocial Medicine is an open access, peer-reviewed online journal that encompasses all aspects of the interrelationships between the biological, psychological, social, and behavioral factors of health and illness. BioPsychoSocial Medicine is the official journal of the Japanese Society of Psychosomatic Medicine, and publishes research on psychosomatic disorders and diseases that are characterized by objective organic changes and/or functional changes that could be induced, progressed, aggravated, or exacerbated by psychological, social, and/or behavioral factors and their associated psychosomatic treatments.
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