Biointerface Research in Applied Chemistry最新文献_第9页

Immunomodulatory and Apoptotic Effect of Cinnamaldehyde in HepG2 Cells 肉桂醛对HepG2细胞的免疫调节和凋亡作用

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.320

{"title":"Immunomodulatory and Apoptotic Effect of Cinnamaldehyde in HepG2 Cells","authors":"","doi":"10.33263/briac134.320","DOIUrl":"https://doi.org/10.33263/briac134.320","url":null,"abstract":"Hepatocellular carcinoma (HCC), associated with various clinicopathological features such as genetic mutations and viral infections, is the fifth most common cancer worldwide. In Asia and Africa, the incidence of HCC is the highest. Half of all cases of HCC are associated with hepatitis B viral infection, with a further 25% associated with the hepatitis C virus. The most widely used drug against liver cancer is Doxorubicin as a single agent or in combination with other 9 chemotherapeutics like Cisplatin. Since the normal hepatocytes are affected by the subsisting conventional chemotherapeutic drugs, the outcomes remain considerably low. Therefore, the field is longing for the discovery of new therapeutic agents without hepatotoxicity or with low hepatotoxicity. Recent studies discovered that an α, β-unsaturated aromatic aldehyde has anti-inflammatory, antiproliferative, and anti-apoptotic against the HepG2 cell line. This α, β-unsaturated aromatic aldehyde is cinnamaldehyde, an extensive component that is present in cinnamon essential oil and is also used as a flavoring agent in food, beverages, and perfume industries. Results showed that the cinnamaldehyde decreased the proliferation of HepG2 cells in a dose-dependent manner (MTT assay). We observed a significant increase in the levels of IL-1 β and a decrease in the levels of IL-10 after Cinnamaldehyde treatment. Cinnamaldehyde also increased the Caspase-3 activity in HepG2 cells significantly. The present study showed that cinnamaldehyde has strong potential as an anti-tumor agent against hepatocellular carcinoma cells.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43683403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Outlook of Covid-19 Curing through Structural and Electronic Properties of Natural Drugs 从天然药物的结构和电子性质看Covid-19的治疗前景

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.345

S. Shahriari, K. Zare, Fatemeh Mollaamin

{"title":"Outlook of Covid-19 Curing through Structural and Electronic Properties of Natural Drugs","authors":"S. Shahriari, K. Zare, Fatemeh Mollaamin","doi":"10.33263/briac134.345","DOIUrl":"https://doi.org/10.33263/briac134.345","url":null,"abstract":"Humans and multiple species of animals must be infected by coronaviruses (positive-stranded RNA viruses) through enteric, respiratory, and central nervous system sickness with attractive targets for designing anti- Covid-19 conjunction. In this work, it has been investigated the compounds of luteolin-7- glucoside, curcumin, epicatechin-gallate, allicin, and zingerol as probable anti-pandemic Covid-19 receptors derived from medicinal plants. Anti-Covid-19 through the hydrogen bonding using the physicochemical features consisting of thermodynamic parameters, nuclear magnetic resonance analysis, and IR characteristics, of luteolin-7- glucoside, curcumin, epicatechin-gallate, allicin, and zingerol compounds binded to the fragment of Tyrosine-Methionine-Histidine as the selective area of the Covid-19, IR frequency and intensity of various normal modes of these structures have been estimated. The theoretical calculations were accomplished at different steps of theory to achieve the more accurate equilibrium geometrical consequences, and IR spectral analysis for each of the complex drugs of O-terminal or N-terminal auto-cleavage substrate were approved to clear the structural flexibility and substrate attaching of seven medicinal plants bonded to the active site of Covid-19 molecule. Comparing these compounds with two configurations prepares a new outlook for the design of substrate-based anti-targeting of Covid-19. This indicates a feasible model for designing a wide spectrum of anti-Covid-19 drugs. The compounds-based energy minimization of these materials has resulted in two more effectual lead compounds, N and O atoms, forming the hydrogen bonding (H-bonding) with potent anti- Covid-19. Finally, two medicinal ingredients of allicin, curcumin, luteolin-7- glucoside, and zingerol bonded to TMH have been directed to a Monte Carlo (MC) simulation and UV-Visible for estimating the absorbance of luteolin-7- glucoside, and epicatechin-gallate.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43729871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

An in silico Molecular Docking and ADME Analysis of Naturally Derived Biomolecules against Xanthine Oxidase: A Novel Lead for Antihyperuricemia Treatment 抗黄嘌呤氧化酶的天然生物分子的硅分子对接和ADME分析:抗高尿酸血症治疗的新先导

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.327

{"title":"An in silico Molecular Docking and ADME Analysis of Naturally Derived Biomolecules against Xanthine Oxidase: A Novel Lead for Antihyperuricemia Treatment","authors":"","doi":"10.33263/briac134.327","DOIUrl":"https://doi.org/10.33263/briac134.327","url":null,"abstract":"Xanthine oxidase (XO) is the significant target enzyme for treating hyperuricemia, gout, and other related illnesses. These clinical problems can be alleviated to some extent by inhibiting the function of xanthine oxidase. Molecules derived from nature can play a key role in this. This study used naturally derived compounds with anticancer action to investigate the binding affinity with XO. Naturally derived molecules retrieved from NPACT (Naturally occurring Plant-based Anticancerous Compound-Activity-Target) database. Molecular docking studies and ADME (Absorption, Distribution, Metabolism, and Excretion) were analyzed. The result of molecular docking studies showed that the selected naturally derived molecules have a better binding affinity with XOthan the standard drug allopurinol. Furthermore, all the selected molecules satisfy the ADME descriptors and have no violation of Lipinski's rule of five. Based on these findings, 18 compounds were chosen for further research. This research will aid in the search for new xanthine oxidase (XO) inhibitor alternatives. Detailed successful in vitro and in vivo studies are needed to propose new drug molecules for treating hyperuricemia and its associated diseases.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43785844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Analysis of Novel Iron Oxide Nanoparticles Synthesized by Different Approaches with Evaluation of Their Antibacterial Activities 不同方法合成的新型氧化铁纳米颗粒的比较分析及其抗菌活性评价

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.317

{"title":"Comparative Analysis of Novel Iron Oxide Nanoparticles Synthesized by Different Approaches with Evaluation of Their Antibacterial Activities","authors":"","doi":"10.33263/briac134.317","DOIUrl":"https://doi.org/10.33263/briac134.317","url":null,"abstract":"In this study, stable novel iron oxide nanoparticles (IO-NPs) were synthesized via chemical and green methods. In the chemical method, p-aminobenzoic acid (AB), diacetyl monoxime (DIA), and adenosine 5-monophosphate disodium (AD) were used as stabilized ligands, whereas the extract of Teucrium apollinis was used in the green synthesis method. The effect of these stabilized ligands on the size, stability, and antibacterial activity of IO-NPs was carried out. The synthesized IO-NPs were characterized using UV-Visible absorption spectroscopy (UV-Vis), dynamic light scattering (DLS), transmission electron microscopy (TEM), and attenuated Fourier transform infrared (ATR-FTIR). IO-NPs offered spherical shapes with small sizes (5 nm, 6 nm, 8 nm, and 34 nm) for IO-NPs functionalized by DIA, AD, AB, and Teucrium apollinis, respectively. This study shows a relationship between the type of NPs and Pseudomonas aeruginosa growth. The IO-NP functionalized by plant extract has a higher antibacterial effect than IO-NPs chemically synthesized. Because it has more infinity toward bacteria cells than other NP, it has a high ability to penetrate the membrane of bacterial cells. The use of Teucrium apollinis extract could be an eco-friendly way to synthesize IO-NP that offers a novel and potential alternative to chemically synthesized IO-NP.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43294321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mullite Ceramics Derived from Fly Ash Powder by Using Albumin as an Organic Gelling Agent 以白蛋白为有机胶凝剂的粉煤灰莫来石陶瓷

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.339

{"title":"Mullite Ceramics Derived from Fly Ash Powder by Using Albumin as an Organic Gelling Agent","authors":"","doi":"10.33263/briac134.339","DOIUrl":"https://doi.org/10.33263/briac134.339","url":null,"abstract":"Mullite is a combination compound of alumina (Al2O3) and silica (SiO2). During the last two decades, mullite ceramics have become the crucial oxide material for both traditional and advanced applications due to their favorable properties, such as good strength at very high temperatures, low density, good thermal shock resistance, and chemically stable. Mullite is also known for its stoichiometry 3Al2O3.2SiO2, or sometimes it is called 3/2 mullite. In this present investigation, the authors attempt to fabricate mullite-based ceramic through a gel casting process by using an organic binder (egg white) to consolidate powder particles, followed by low-temperature sintering. Fly ash powder, china clay powder, and alumina powder were used as raw materials to make mullite ceramic. Green bodies were fabricated by taking various proportions of fly ash, china clay, and alumina, followed by sintering at 1200C, 1250C, and 1300C for 2 hours. The stability of slurries was studied by measuring zeta potential, and green sample fracture surfaces were analyzed by Field Emission Scanning Electron Microscopy (FESEM). Physical properties of sintered samples, such as linear shrinkage, density, porosity, and water absorption, were also calculated. Evidence of mullite formation was characterized by Field Emission Scanning Electron Microscopy (FESEM scanning electron microscopy (SEM) techniques. The samples containing 45 wt.% fly ash, 15 wt.% china clay, and 40 wt.% aluminas showed the best physical properties compared to other batch compositions and were well supported by the results obtained from FESEM results.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46235484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Role of Fibronectin and its Isoforms in the Pathogenesis and Progression of Rheumatoid Arthritis: A Review 纤维连接蛋白及其异构体在类风湿性关节炎发病机制和进展中的作用

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.341

引用次数: 2

Implementation of Principal Component Analysis-Cluster Analysis on The Extraction of Green Tea Leaf (Camellia sinensis (L.) Kuntze) 主成分分析聚类分析在绿茶叶提取中的应用

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.335

{"title":"Implementation of Principal Component Analysis-Cluster Analysis on The Extraction of Green Tea Leaf (Camellia sinensis (L.) Kuntze)","authors":"","doi":"10.33263/briac134.335","DOIUrl":"https://doi.org/10.33263/briac134.335","url":null,"abstract":"Several green tea leaf extraction studies only describe the results of the extraction method or the different types of solvents that produce the highest levels of polyphenols or caffeine without further analysis by statistical analysis. In addition, the statistical analysis method still often used is a statistical analysis of variance, which has weaknesses. This study used PCA and CA methods to analyze samples based on the solvent's effect on temperature and pH. The solvents used in extracting green tea leaves were hot distilled water at ±95oC, distilled water, citrate buffer pH 4.3, and phosphate buffer pH 7.4 without heating (±25oC). The parameters analyzed were yield, water content, total ash content, acid insoluble ash content, total polyphenol content, and caffeine in green tea leaf extract (Camellia sinensis (L.) Kuntze). Classification with PCA results in a 2-dimensional data reduction that represents all data. Therefore, PC1 can extract as much as 68.7% of the information, and PC2 can extract 22.9% of the information. Cumulatively, PC1 and PC2 extracted as much as 91.5% of the information. Classification with CA resulted in 3 clusters. The third cluster, namely numbers 2 and 3, is the cluster that has the closest similarity with the distance between the cluster centroids of 2.08564 and the similarity level of 56.7850%.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47055378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Biomedical Applications of Bisphosphonate Chelating Agents by Metal Cations as Drug Design for Prevention and Treatment of Osteoporosis using QM/MM Method 金属阳离子双膦酸盐螯合剂在骨质疏松防治药物设计中的应用QM/MM方法

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.329

{"title":"Biomedical Applications of Bisphosphonate Chelating Agents by Metal Cations as Drug Design for Prevention and Treatment of Osteoporosis using QM/MM Method","authors":"","doi":"10.33263/briac134.329","DOIUrl":"https://doi.org/10.33263/briac134.329","url":null,"abstract":"By investigating their pharmacological activity, bisphosphonate drugs can be employed to prevent the loss of one density and treat bone diseases like osteoporosis. The capability of bisphosphonates is to be stuck and be kept within bone during osteoclast-mediated bone inorganic material decomposition. The main problem accompanied by their application is their low oral bioavailability. Several delivery systems, such as metal chelating, nanoparticles, and contrast agents, have been selected to modify their absorption and to conduct them to sites other than bone cells. In this contribution, we have investigated the pharmacological and clinical application of bisphosphonate drugs of 5AFX, 4QPF, 3DYG, 2I19, and 2F92 using novel QM/MM applications of DFT, MC, and MD due to physicochemical properties of NMR, charge transfer, Gibbs free energy, electronic-kinetic and nuclear repulse energies in the pharmaceutical and biomedical fields. The bisphosphonate agent has been accomplished in chelation with the metal cation of Mg2+ and Cu2+ through the PDB structures of 5AFX, 4QPF, 3DYG, 2I19, and 2F92 drugs. Since the metal binding of phosphonate groups is relatively bulky, with six oxygens having a negative charge more than pH= 4, which is high (approximately four per ligand), these structures are active in forming the chelated compounds through the drug design method. The connection between structure and activity methods play an important role in predicting the biological properties of target compounds and their physicochemical properties. In this article, Ramachandran plot in drug design has played an efficient function in target identification and designing novel drugs for exploring the parameters of amino acid sequence, molecular modeling, and the 3-D structure bisphosphonate agents of novel drugs of 5AFX, 4QPF, 3DYG, 2I19, and 2F92.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48486592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Bioactive Components and Health Benefits of Maize-based Fermented Foods: A Review 玉米发酵食品的生物活性成分及其对健康的益处

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.338

{"title":"Bioactive Components and Health Benefits of Maize-based Fermented Foods: A Review","authors":"","doi":"10.33263/briac134.338","DOIUrl":"https://doi.org/10.33263/briac134.338","url":null,"abstract":"Maize is one of the very important cereals which contains major nutrients, carbohydrates, proteins, vitamins, minerals, and various other constituents like β-glucan, oligosaccharides, and resistant starch. Maize contains various bioactive components like phenolic acids, flavonoids, carotenoids, and phytosterols. These effectively prevent and cure diseases such as night blindness, age-related disorders, cardiovascular and neural disorders, and colon cancer. The fermentation of maize using Lactic Acid Bacteria to produce traditionally fermented foods is one of the ancient health-promoting formulae to achieve the health benefits of cereal ingredients and live beneficial bacteria. These microbes exert various probiotic effects on consumer health and are explored as a source of probiotic strains. The fermented maize-based foods are economical, have enhanced sensory and nutritional quality, reduce the risk of detrimental diseases, improve shelf life, and produce antimicrobial substances and health-stimulating compounds. This review emphasizes maize's nutritional and phytochemicals composition, diversity of important maize-based fermented foods and beverages, health benefits of consumption, and future perspectives and challenges.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45811549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Could Celastrol Nanosystem be Suitable for the Treatment of COVID-19? Celastrol纳米系统是否适用于治疗新冠肺炎？

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.340

Siu Kan Law, Dawn Chingtung Au, Albert Wingnang Leung, Chuanshan Xu

引用次数: 0