Biointerface Research in Applied Chemistry最新文献_第8页

Synthesis, Characterization, Antioxidant and Antibacterial Activities of Six Metal Complexes Based Tetradentate Salen Type Bis-Schiff Base 六种四齿Salen型双Schiff碱金属配合物的合成、表征、抗氧化和抗菌活性

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.333

{"title":"Synthesis, Characterization, Antioxidant and Antibacterial Activities of Six Metal Complexes Based Tetradentate Salen Type Bis-Schiff Base","authors":"","doi":"10.33263/briac134.333","DOIUrl":"https://doi.org/10.33263/briac134.333","url":null,"abstract":"Considering the importance of metal complexes in the development of medicinal chemistry, a series of transition metal complexes of Co(II), Fe(II), Zn(II), Cu(II), and Ni(II) has been synthesized from N,N'-bis(salicylidene)-2,2-dimethyl-1,3-diaminopropane H2L Schiff base ligand. The reaction of the H2L with the selected metal ions led to tetrahedral and octahedral coordinated complexes. The structural features of the obtained metal complexes were determined using analytical techniques such as FT-IR, NMR, UV-Vis, X-ray powder diffraction, mass spectrometry, and Thermogravimetry–differential thermal (TGA/DTA) analysis. The measured conductance for obtained compounds has shown the electrolytic behavior of all obtained complexes. The synthesized ligand and corresponding complexes were screened for their antioxidant and antibacterial activities. Indeed, Co(II) and Fe(II) complexes have shown excellent antioxidant activities for DPPH radical scavenging and FRAP assays, respectively. The results obtained from the disc diffusion assay showed that Co(II), Fe(II), Zn(II), and Cu(II) complexes had displayed promising antibacterial activity against Escherichia coli and Staphylococcus aureus, while no effect has been observed on both strains for ligand H2L and its corresponding Ni(II) complex.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45948251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Intracytoplasmic Trafficking of Nanoparticles based on Hyaluronic Acid and Chitosan for Targeted Delivery of Anticancer Drugs 基于透明质酸和壳聚糖的抗癌药物靶向递送纳米粒子的胞浆内转运

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.344

{"title":"Intracytoplasmic Trafficking of Nanoparticles based on Hyaluronic Acid and Chitosan for Targeted Delivery of Anticancer Drugs","authors":"","doi":"10.33263/briac134.344","DOIUrl":"https://doi.org/10.33263/briac134.344","url":null,"abstract":"Cancer diseases are characterized by high incidence and mortality worldwide. The main problem in cancer therapy is the lack of specificity of anti-cancer drugs. Therefore, the development of new methods of targeted delivery of anti-cancer drugs is an urgent task in oncology. Nanoparticles from hyaluronic acid and chitosan (HA:CS) were obtained using ionotropic gelation technology. The size of the nanoparticles was investigated using dynamic light scattering. Nanoparticles were obtained of a size of 100-400 nm. A physical association method has been developed for encapsulating nanoparticles with doxorubicin, a well-known antitumor drug, and dinitrosyl iron complex (DNIC; donor of nitric oxide). Using the method of dynamic light scattering, the surface potential of nanoparticles was measured. It was found that the resulting nanoparticles (HA-DOX:CS) were stable and had a surface potential of -45.6 meV. Using the method of confocal and FLIM microscopy, the localization of nanoparticles in cancer cells was studied. These methods have shown that nanoparticles pass through the cytoplasmic membrane and are localized inside the cells. It was also shown that nanoparticles (HA:CS-Rhod) were localized in the cytoplasm of African green monkey renal epithelial cells. It was found that the incorporation of DNIC into the composition of nanoparticles significantly increased the stability of DNIC, while prolonging the formation time and increasing the yield of nitric oxide. Thus, we have developed unique nanoparticles for the targeted delivery of antitumor drugs into cells.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46172589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyethylene Glycol as New Permeation Enhancer in Thermosensitive Mucoadhesive Hydrogels Containing Hydrophobic Compound for Vaginal Delivery: An Ex Vivo Proof of Concept Study 聚乙二醇在含疏水化合物的热敏黏附水凝胶中作为新的渗透增强剂用于阴道输送:一个离体概念研究的证明

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.315

引用次数: 1

A Short Commentary of the Quality Control on Radix Salvia miltiorrhiza and its Application for COVID-19 丹参的质量控制及其在新型冠状病毒病中的应用

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.316

X. Lu, Yu Wang, Dawn Chingtung Au, W. Y. Chow, Siu Kan Law

引用次数: 1

Profile Volatile Compounds in Essential Oils on Different Parts of Cardamom with Antioxidant Activity 豆蔻不同部位精油中具有抗氧化活性的挥发性成分

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.328

{"title":"Profile Volatile Compounds in Essential Oils on Different Parts of Cardamom with Antioxidant Activity","authors":"","doi":"10.33263/briac134.328","DOIUrl":"https://doi.org/10.33263/briac134.328","url":null,"abstract":"Amomum compactum Soland Ex. Maton from the Zingiberaceae, known as Java cardamom in Indonesia, is a valuable medicinal plant because of its bioactivity. This study aims to identify and evaluate the bioactive compounds and antioxidant activity of Java cardamom parts (leaves, stems, rhizomes, fruits (pods and seeds)) to explore their bioactivity values. GC-MS analysis was used to identify the bioactive compounds of Java cardamom parts in essential oils. Antioxidant activity was carried out by two methods: DPPH and FRAP. GC-MS analysis of four parts of the Java cardamom obtained 47 compounds as monoterpenes (33), sesquiterpenes (9), hydrocarbons (1), fatty alcohols (1), fatty acids (1), fatty acid esters (1), and diterpenoids (1). 1.8-Cineol is the most dominant secondary metabolite and is found in every part of Java cardamom essential oil, with the highest content produced in Java cardamom steam essential oil (50.78%), followed by Java cardamom fruits essential oil (45.59%). Furthermore, the activity of DPPH and FRAP ranged from 19.07 (leaves) – 27.38 (stems) and 93.43 (stems) – 115.99 (fruits) mol TEAC/g FW. The maximum antioxidant activity is produced in Java cardamom fruit essential oil. Thus, it can be used as a source of producing metabolites as antioxidants in the pharmaceutical industry.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45754649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effect of Environment on Mechanical Behavior of Thermosetting Composites Reinforced with Bio-filler (Orange Peel Particulate) Materials 环境对生物填料（橘皮颗粒）增强热固性复合材料力学性能的影响

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.312

{"title":"Effect of Environment on Mechanical Behavior of Thermosetting Composites Reinforced with Bio-filler (Orange Peel Particulate) Materials","authors":"","doi":"10.33263/briac134.312","DOIUrl":"https://doi.org/10.33263/briac134.312","url":null,"abstract":"The behavior of natural fiber depends upon different environmental conditions due to its hydrophilic nature. Therefore, this article has focused on the significant consequence of moisture absorption on the mechanical properties of bio-waste (orange peel) reinforced epoxy composites with different weight percentages (10%, 20%, and 30%) in different environmental conditions such as saline water treatment, steam treatment, and subzero temperature. After attaining saturation, the experiments were carried out by immersing the specimens in previously described environmental conditions—the percentage of moisture content in the fabricated composite increases with an increase in the filler loadings. The mechanical properties of environmentally affected composites were studied as per ASTM standards, and the same values were compared with the properties of the composite in normal environmental conditions. The cracked surface of the tested samples and morphology of orange peel particulates were analyzed by scanning electron microscope. X-ray diffraction and energy-dispersive spectroscopy (EDX) analysis also studied the characterization of orange peel particulates.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44799734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of Cobalt Substitution on the Structural, Optical Band Gap, and Photocatalytic Dye Degradation Properties of Spray Deposited SnO2Thin Films 钴取代对喷射沉积SnO2薄膜结构、光学带隙和光催化降解染料性能的影响

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.321

引用次数: 0

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.332

{"title":"Mechanisms Related to Inhibition of Fungal Biofilm Formation on Medical Device Coated with Poly(Methylmethacrylate-co-Dimethylacrylamide)","authors":"","doi":"10.33263/briac134.332","DOIUrl":"https://doi.org/10.33263/briac134.332","url":null,"abstract":"Candida albicans (C. albicans) are the most common cause of urinary fungal infections. C. albicans biofilms are of increasing clinical importance due to their resistance to antifungal therapy. Since the use of medical devices causes most hospital infections, polymeric coatings that reduce microorganisms adhesion and biofilm formation are considered an attractive strategy. In this work, the ability and possible mechanisms of poly(methylmethacrylate-co-dimethylacrylamide) (PMMDMA) to inhibit C. albicans biofilms on medical devices have been studied. Scanning electron microscopy was used to evaluate fungal adhesion at various pH conditions, while the surface roughness of the coated and uncoated catheters was analyzed by atomic force microscopy. The surface charge was assessed, and the contact angle was determined to evaluate the surface hydrophobicity. PMMDMA coated catheters showed reduced binding of C. albicans at all pH values studied and presented a hydrophilic contact angle of ϴ = 71°. Negative zeta potential values of PMMDMA enhanced the reduction in C. albicans binding. AFM images demonstrated a smoother and homogeneous surface of PMMDMA-coated catheters. Coating with PMMDMA provided a smoother, more hydrophilic, and negative-charged surface, contributing to a substantial reduction of C. albicans binding.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41526509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Constituents, Medicinal, and Pharmacological Applications, and Toxicology of Fructus Zizyphi 酸枣的化学成分、药用、药理应用及毒理学研究

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.331

{"title":"Chemical Constituents, Medicinal, and Pharmacological Applications, and Toxicology of Fructus Zizyphi","authors":"","doi":"10.33263/briac134.331","DOIUrl":"https://doi.org/10.33263/briac134.331","url":null,"abstract":"Fructus Zizyphi refers to the fruits of Zizyphus jujuba plant, and this plant is geographically distributed in East Asia and South Europe. This plant belongs to the family Rhamnaceae, and this plant is a shrub of 10 m in height. This review aimed to focus on chemical constituents, medicinal and pharmacological applications, and the toxicology of Fructus Zizyphi. The major chemical constituents of Fructus Zizyphi are triterpenes and triterpene saponins. Fructus Zizyphi treats insomnia, increases body weight, strengthens body muscle, decreases body temperature, increases urine volume, accelerates women's period, calms and reinforces agents, chases phlegm, treats vision, skin inflammation, hepatitis, respiratory diseases, diabetes, gastric ulcer, and different skin wounds. The pharmacology of Fructus Zizyphi includes experimental pharmacology and clinical pharmacology. Experimental pharmacology includes antiallergenic, anti-inflammatory, analgesic, anti-hyperglycemic, anti-hypercholesterolemic, central nervous system depressant, immune stimulation, and platelet aggregation activities. Fructus Zizyphi ethanol extracts to mice in drinking water daily for 3 months without any effect on animal death, hematology, organ weight, or sperm secretion. Fructus Zizyphi was not mutagenic. Fructus Zizyphi declined gastric adenocarcinoma progress. Fructus Zizyphi without general precautions, drug connections; drug and laboratory test relations; teratogenic or non-teratogenic effects in pregnancy; nursing mothers; or pediatric use. In conclusion, Fructus Zizyphi had antiallergenic, anti-inflammatory, analgesic, anti-hyperglycemic, anti-hypercholesterolemic, central nervous system depressant, immune stimulation, platelet aggregation activities, and without any effect on animals death, hematology, organ weight or sperm secretion.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49623244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mathematical Modelling of Convective Diffusive Mass Transfer in Ferrofluids Concerning Targeted Drug Delivery 靶向给药铁流体对流扩散传质的数学模型

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.311

引用次数: 0