Biointerface Research in Applied Chemistry最新文献_第7页

Dye Elimination by Surface-Functionalized Magnetite Nanoparticles: Kinetic and Isotherm Studies 表面功能化磁铁矿纳米粒子去除染料的动力学和等温研究

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.325

引用次数: 0

Bioactivity of Heterotrigona itama Propolis as Anti-Inflammatory: A Review 异三角蜂蜂胶抗炎生物活性研究进展

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.326

引用次数: 0

A Review: Pharmacological Activities of Quinoline Alkaloid of Cinchona sp. 金鸡纳喹啉生物碱的药理活性研究进展。

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.319

{"title":"A Review: Pharmacological Activities of Quinoline Alkaloid of Cinchona sp.","authors":"","doi":"10.33263/briac134.319","DOIUrl":"https://doi.org/10.33263/briac134.319","url":null,"abstract":"Cinchona is a plant used in traditional malaria treatment. This review aims to examine pharmacological activities to increase the benefits and uses of the bioactive compounds found in the bark of the Cinchona trees as medicine and cosmetics. A literature search was conducted through the internet database https://pubmed.ncbi.nlm.nih.gov/; https://scholar.google.com/; https://www.sciencedirect.com/; https://www.wiley.com/en-us from 1998-2022. The main phytochemical content of Cinchona bark is quinoline alkaloids (quinine, cinchonidine, cinchonine, and cinchonidine), with total alkaloid concentrations varying between 6 and 15% (Cinchona succirubra ranging from 5-7%, Cinchona calisaya 4-7% and Cinchona ledgeriana 5-14%). Cinchona quinoline alkaloids have the same active site on the nitrogen atom in the quinuclidine ring and the methylene alcohol functional group, which plays an essential role in their pharmacological activity. Besides being used as an antimalarial, Cinchona alkaloids are currently being developed as their anticancer, antioxidant, antidiabetic, antifungal, muscle cramps, hair growth stimulant, antimicrobial, antiobesity, antiplatelet, antiviral, anesthetic, and antipyretic properties. Conclusion: Quinoline alkaloids of Cinchona sp have various pharmacological activities that have the potency to be developed as drugs and cosmetics.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47545015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Etanercept and Infliximab, Two Tumor Necrosis Factor-α (TNF-α) Inhibitors With Different Action Profiles: An In vitro and In Vivo Study in the Context of Reviewed Therapeutic Applications 依那西普和英夫利昔单抗，两种具有不同作用谱的肿瘤坏死因子-α (TNF-α)抑制剂:在回顾治疗应用背景下的体外和体内研究

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.309

{"title":"Etanercept and Infliximab, Two Tumor Necrosis Factor-α (TNF-α) Inhibitors With Different Action Profiles: An In vitro and In Vivo Study in the Context of Reviewed Therapeutic Applications","authors":"","doi":"10.33263/briac134.309","DOIUrl":"https://doi.org/10.33263/briac134.309","url":null,"abstract":"Tumor necrosis factor-α (TNF-α) is a cytotoxic cytokine in vitro. It mediates septic shock, apoptosis, and inflammation in vivo. The in vitro work was used for testing the effect of Etanercept (ETA) and Infliximab (INF) against cell cytotoxicity caused by TNF-α. At the same time, the in vivo work was used to test the effect of the two tested agents on TNF-α serum levels in rats induced by lipopolysaccharides (LPS). Upon in vitro testing of the protective effect of both agents on the WI38 cells, it was found that ETA was superior to INF for antagonizing the effect of TNF-α whether the tested agent and TNF-α were simultaneously added to the cell line or the antibody addition proceeded TNF-α addition. In vivo testing of the effect of both agents showed that they significantly antagonized the effect of TNF-α with superior effect in case of ETA whether each tested agent was administered at four doses separated by one-week interval before LPS injection or it was administered once 24 hours after LPS administration. This study gave evidence for a differential antagonizing effect of ETA and INF against TNF-α with superior action in the case of ETA when they were assessed both in vitro and in vivo.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44913513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cortex Uncariae: A Review on Pharmacology, Toxicology, Precautions, and Dosage 钩藤皮:药理、毒理学、注意事项及用量综述

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.334

{"title":"Cortex Uncariae: A Review on Pharmacology, Toxicology, Precautions, and Dosage","authors":"","doi":"10.33263/briac134.334","DOIUrl":"https://doi.org/10.33263/briac134.334","url":null,"abstract":"Cortex Uncariae is the stem of Uncaria tomentosa plant, which belongs to the family Rubiaceae. Cat's thorn and unha de gato are the famous names of Cortex Uncariae. Uncaria tomentosa plant is widely geographically distributed in Central and South American countries. The aim of this review was to focus on pharmacology, toxicology, precautions, and dosage of Cortex Uncariae. The indole alkaloids such as speciophylline, mitraphylline, pteropodine, uncarine F, and isomitraphylline, as well as tetracyclic alkaloids oxindoles such as isorhynchophylline and rhynchophylline are the major Cortex Uncariae chemical constituents. There are many medical applications of Cortex Uncariae, such as immunostimulant agents, increases the white blood cells and immunity, treatment of gastrointestinal ulcers, rheumatism, arthritis, viral infection, urinary tract infections, fever, asthma, abscesses, high blood pressure, high blood glucose, and high total cholesterol. Pharmacology of Cortex Uncariae includes experimental pharmacology and clinical pharmacology. Experimental pharmacology contains anti-inflammatory, antidepressant, neuroprotection, antitumor, immune-stimulating, and anti-obesity activities, while clinical pharmacology contains immune-stimulating activity. No acute or chronic toxicity was recorded after Cortex Uncariae water extract administration. Cortex Uncariae extract did not accompany loss of food intake, body or organ weight decrease, and no histopathological changes were recorded in the main body organs such as kidney, liver, spleen, and heart after Cortex Uncariae intake. Cortex Uncariae must store in a closely black container to avoid heat and light. In conclusion, Cortex Uncariae had anti-inflammatory, antidepressant and neuroprotection, antitumor, immune-stimulating, anti-inflammatory, and anti-obesity activities without acute or chronic toxicity.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47138430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Performance of Two Immunochromatographic Tests for the Rapid Detection of PCR Confirmed, Carbapenemase Producing-Enterobacterales 两种免疫层析快速检测PCR确认的产碳青霉烯酶肠杆菌的性能比较

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.322

{"title":"Comparative Performance of Two Immunochromatographic Tests for the Rapid Detection of PCR Confirmed, Carbapenemase Producing-Enterobacterales","authors":"","doi":"10.33263/briac134.322","DOIUrl":"https://doi.org/10.33263/briac134.322","url":null,"abstract":"The Gram-negative bacilli (GNB) tend to dominate the infectious pathology, often due to multidrug-resistant (MDR) strains and evolving with severe, complicated, and difficult-to-treat clinical forms. This study aimed to investigate by phenotypic and genotypic assays a representative set of carbapenem-resistant GNB strains to evaluate their contribution to appropriate epidemiological surveillance and therapy of associated infections. A number of 70 Enterobacterales MDR bacterial strains were consecutively isolated from patients with different infections (79 %) and carriers (rectal portages, 21 %) hospitalized at the Fundeni Clinical Institute from November 2017 - April 2018. The strains, previously characterized by PCR, were investigated comparatively by two immunochromatographic tests, NG-Test Carba 5 and RESIST-3 O.K.N., able to detect KPC, OXA-48 like NDM, VIM, IMP, and OXA-48 like, KPC, NDM, respectively. KPC was the main carbapenemase detected (37 %), followed by OXA-48 (30 %). Both rapid immunochromatographic tests demonstrated high sensitivity and specificity, the results being 100 % concordant with the results of the PCR method. The immunochromatographic assay is, therefore, a cheap and reliable method for the rapid detection, within 15 minutes, of carbapenemase-producing strains. Rapid and accurate identification of carbapenemases is significant for clinical and epidemiological purposes, infection control, and antimicrobial therapy's effectiveness.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44396344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Study of the Electronic Properties of a Fluoropyrazolecarbonitrile Derivative and Enhancement of Spectral Properties on Adsorption with Fullerene 氟吡唑腈衍生物的电子性质及富勒烯吸附增强光谱性质的研究

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.342

引用次数: 4

Carbon Dioxide Adsorption by a Zinc-Doped Nanocage: DFT-Based Computational Assessment of Gas Pollution Detection and Removal 掺杂锌纳米笼对二氧化碳的吸附:基于dft的气体污染检测和去除的计算评估

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.337

{"title":"Carbon Dioxide Adsorption by a Zinc-Doped Nanocage: DFT-Based Computational Assessment of Gas Pollution Detection and Removal","authors":"","doi":"10.33263/briac134.337","DOIUrl":"https://doi.org/10.33263/briac134.337","url":null,"abstract":"The high level of carbon dioxide (CO2) greenhouse gas exhaustion to nature could make it a serious pollutant with negative impacts on human and environmental health safety. In this regard, the current work was performed to run computational assessments on employing zinc (Zn)-doped nanocage (C19Zn) for adsorbing the CO2 gaseous substance to approach the detection and removal goals. Accordingly, geometries of the model systems were optimized using density functional theory (DFT) calculations to obtain the minimized energy structures besides evaluating their energy features. The obtained features approved the formation of interacting bimolecular CO2@C19Zn complex of quantum theory of atoms in molecules (QTAIM) analysis, and the evaluated strength indicated the existence of a physical O…Zn interaction for the formation of such a complex system. Moreover, the evaluated electronic molecular orbital features indicated the possibility of detection function for the investigated system. The obtained results of this work revealed that the formation of the CO2@C19Zn complex model could be supposed to conduct two functions of detection and removal of CO2 by the investigated C19Zn nanocage for approaching the issues of dealing with greenhouse pollutants.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49186064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation, Characterization, and Antioxidant Activity of Selliguea taeniata Secondary Metabolites 带翅Selliguea taeniata次级代谢产物的分离、表征及其抗氧化活性

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.330

{"title":"Isolation, Characterization, and Antioxidant Activity of Selliguea taeniata Secondary Metabolites","authors":"","doi":"10.33263/briac134.330","DOIUrl":"https://doi.org/10.33263/briac134.330","url":null,"abstract":"This current study presents a chemical exploration of the methanolic extract of Selliguea taeniata leaves, a fern species endemic in certain regions in the Philippines, such as Ifugao, where it is used to treat cough for good health and well-being of the folks. Although botanical data of this fern are reported, there are still no reports regarding its chemical properties, such as phytochemicals and antioxidant activity, as of the time this study was conducted. The air-dried leaves of S. taeniata were extracted using absolute methanol. The crude extract was concentrated and subjected to the Folin-Ciocalteu method to determine the total phenolic content (TPC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay to evaluate its antioxidant activity, and phytochemical screening. Subsequently, various chromatographic techniques and 1H Nuclear Magnetic Resonance spectroscopy were applied to isolate and partially characterize its secondary metabolites partially. Methanolic extract of S. taeniata leaves had a TPC of 1669.11 ± 0.07 mg GAE /g of dried sample and antioxidant activity (EC50= 85.79 ± 0.02 ppm). The crude extract contained alkaloids, flavonoids, cardiac glycosides, saponins, phenols, and tannins. Partial isolation of its secondary metabolites suggested that the crude extract may contain a mixture of proanthocyanidins or its monomer units and glycosides. The claims of the folks from Ifugao on the effectivity of Selliguea taeniata leaf decoction as an antitussive can be attributed to the plant's high antioxidant activity. The extract contained phenolic compounds that could be proanthocyanidins, inhibiting elastase that promotes inflammation.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46358063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Docking Interactions with Mycobacterial ATP and Polyketide-13 Synthase Enzymes of Phytoconstituents Isolated from Entada abyssinica Stem Bark 深菜茎皮植物成分与分枝杆菌ATP和聚酮-13合成酶的分子对接作用

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.323

{"title":"Molecular Docking Interactions with Mycobacterial ATP and Polyketide-13 Synthase Enzymes of Phytoconstituents Isolated from Entada abyssinica Stem Bark","authors":"","doi":"10.33263/briac134.323","DOIUrl":"https://doi.org/10.33263/briac134.323","url":null,"abstract":"The search for novel therapies for tuberculosis continues due to the emergence of resistant strains, adverse drug reactions, and potential drug-drug interactions of antitubercular drugs. This study was undertaken to identify compounds from Entada abyssinica, a plant used by herbalists in East Africa for the management of symptoms of tuberculosis. An extract of shade-dried E. abyssinica stem bark was prepared by maceration in a mixture of acetone and methanol in the ratio of 3:2. Column and thin layer chromatography were used to isolate pure compounds. The structures of the compounds were elucidated using nuclear magnetic resonance and infrared spectroscopy. The compounds were further studied using in silico tools to predict their binding affinities, descriptors of pharmacokinetics, and toxicity. Seven known compounds: 2,3-dihydroxypropyltriacontanoate (1), 1',26'-bis-(2,3-dihydroxypropyl) hexacosanedioate (2), stigmasterol 3-O--D-glucopyranoside (3), sitosterol 3-O--D-glucopyranoside (4), Spinasterol 3-O--D-glucopyranoside (5), stigmasterol (6) and spinasterol (7) were isolated. Compounds 1 and 2 had better binding affinities (-27.7374 and -28.5726 Kcal/mol) than the bedaquiline (-22.9042 Kcal/mol) for ATP. All isolated compounds had better binding affinities (between -21.4357 and -18.7809 Kcal/mol) than isoniazid (-10.8307 Kcal/mol) for polyketide-13 synthase enzymes. The compounds showed variable but promising pharmacokinetic properties with minimum toxicity. E. abyssinica stem bark contains phytochemicals with promising antimycobacterial activity via inhibition of the ATP and polyketide-13 synthase enzymes. In vitro and in vivo studies are recommended to validate the predicted antimycobacterial activity as well as the pharmacokinetics and toxicity profiles.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43941673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0