Biointerface Research in Applied Chemistry最新文献_第10页

Combinatorial Approach of Polymeric Patches and Solid Microneedles for Improved Transdermal Delivery of Valsartan: A Proof-of-Concept Study 聚合物贴片和固体微针的组合方法改善缬沙坦的透皮给药:概念验证研究

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.314

{"title":"Combinatorial Approach of Polymeric Patches and Solid Microneedles for Improved Transdermal Delivery of Valsartan: A Proof-of-Concept Study","authors":"","doi":"10.33263/briac134.314","DOIUrl":"https://doi.org/10.33263/briac134.314","url":null,"abstract":"Valsartan (VALS) is a first-line therapy for hypertension that belong to the Angiotensin II Receptor Blockers class. VALS is currently administered orally, but it is associated with its low bioavailability. The transdermal route can be an alternative to overcome this problem. However, this route has low permeation caused by the presence of stratum corneum on the skin. The use of permeation enhancers is needed. This study aims to determine the effect of PEG 400 concentration on physical characteristics and release of VALS from transdermal patch preparations and determine the effect of solid microneedles on VALS permeation. The transdermal patch formula was made using HPMC as a base and PEG 400 as a permeation enhancer with various concentrations. The patches were evaluated for their physical appearance, weight uniformity, thickness, moisture content, folding endurance, drug content, in vitro drug release, in vitro drug permeation, and ex vivo permeation test. The results showed that all formulations showed good characteristics for transdermal administration, and the use of PEG 400 could increase the permeation of VALS. Importantly, when combined with solid microneedles, the permeation of VALS was significantly improved. To conclude, the combination of VALS patch transdermal and MNs can increase the amount of VALS permeated.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44250343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Concomitant Production of α-Amylase and Protease by Bacillus Aerius Strain FPWSHA Isolated from Food Wastes 食物垃圾中分离的Aerius芽孢杆菌菌株FPWSHA并发α-淀粉酶和蛋白酶的研究

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI: 10.33263/briac134.310

{"title":"Concomitant Production of α-Amylase and Protease by Bacillus Aerius Strain FPWSHA Isolated from Food Wastes","authors":"","doi":"10.33263/briac134.310","DOIUrl":"https://doi.org/10.33263/briac134.310","url":null,"abstract":"Amylase and protease are enzymes that have potential applications in the food industry, detergent formulation, pharmaceuticals, waste degradation, and the dehairing process in the leather-making industry. In the current study, fifty-six bacteria were isolated from food wastes and screened for amylase and protease production. Biochemical tests and 16S rRNA gene sequencing were used to characterize and identify bacterial strains. Ten potential isolates with high extracellular enzyme secretion were selected. Among ten isolates, strain FPWSHA was ideal for α-amylase and protease production based on its larger hydrolytic zone of clearance under casein and starch agar than other isolates. This strain was identified as Bacillus aerius FPWSHA (Accession number in GenBank: OM258619) and utilized to produce protease and α-amylase enzymes using potato peels powder (PPP) waste as a cheap substrate under submerged fermentation. Under culture conditions optimization, 16.9 U/mL amylase and 12.3 U/mL proteases were achieved within 48 h of fermentation. Bacillus aerius was isolated from food wastes for the first time to produce α-amylase and protease enzymes. In the future, the bacterial strain described here should be improved for hydrolytic enzyme production in commercial and biotechnological applications.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48472373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Genetic Variants and Biochemical Parameters Associated with the Risk for Venous Thromboembolism in a Romanian Cohort 罗马尼亚队列中与静脉血栓栓塞风险相关的遗传变异和生化参数

Biointerface Research in Applied Chemistry Pub Date : 2022-09-10 DOI: 10.33263/briac134.308

{"title":"Genetic Variants and Biochemical Parameters Associated with the Risk for Venous Thromboembolism in a Romanian Cohort","authors":"","doi":"10.33263/briac134.308","DOIUrl":"https://doi.org/10.33263/briac134.308","url":null,"abstract":"Thrombophilia can be defined as a predisposition to form clots inappropriately. We studied the carrier status for thrombophilia-related genetic variants in a cohort of 237 Romanian patients who were referred to Synevo Romania between January 2021 and April 2021. Two groups of patients consisting of 117 subjects were evaluated for the underlying causes of a VTE (venous thromboembolism) - group A and group B, consisting of 120 patients with no thromboembolic events. All patients were screened for PC, PC, AT-III, FVL, FII, and MTHFR. The presence of thrombophilia was compared between groups. Out of the 117 patients in group A, 113 (96.58 %), revealed at least one of the analyzed mutations, while just 4 (3.41 %) there were no identified mutations; in comparison, the mutation carrier/non-carrier ratio in group B was 104 patients (86.67%) and 16 (13.33%), respectively. The prevalence of FVL and FII mutation in group A, 21/117 (17.94%) heterozygous and 17/117 (14.53%) heterozygous, respectively, was notably higher when compared to 10/120 (8.33%) FVL heterozygous and 6/120 (5%) FII heterozygous in group B (p=0.034 and p=0.0156). The prevalence of inherited natural anticoagulants was comparable between groups with no statistically significant difference (p=0.6592, p= 0.0992, p= 0.6809).","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46675726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cryoprotective Effect of Pyrano-[2,3-C]-Pyrazoles on H2O2 Induced Damage in Tetrahymena thermophila 吡喃-[2,3-C]-吡唑类化合物对高温四膜虫H2O2损伤的低温保护作用

Biointerface Research in Applied Chemistry Pub Date : 2022-09-10 DOI: 10.33263/briac134.305

引用次数: 1

Review on Computer-Aided Drug Design (CADD) Technique in Drug Discovery Researches and Solvent-Free Synthesis of 3,4-Dihydropyrimidin-2-(1H)-Ones/Thiones Catalyzed by Camphor Sulfonic Acid 计算机辅助药物设计技术在药物发现研究和樟脑磺酸催化无溶剂合成3,4-二氢嘧啶-2-（1H）-酮/噻吩中的应用综述

Biointerface Research in Applied Chemistry Pub Date : 2022-09-10 DOI: 10.33263/briac134.303

引用次数: 0

Analysis of Distance 2 Topological Models of Alkanes 烷烃的距离2拓扑模型分析

Biointerface Research in Applied Chemistry Pub Date : 2022-09-10 DOI: 10.33263/briac134.307

引用次数: 0

Quantitative Structure-Property Relationship Analysis on Priority PAHs Using Certain Closed Neighbourhood Topological Indices 基于封闭邻域拓扑指标的优先多环芳烃定量构性关系分析

Biointerface Research in Applied Chemistry Pub Date : 2022-09-10 DOI: 10.33263/briac134.306

引用次数: 0

Interactive Performance of Wheat Nitrogen Fertilization and Inoculation with Growth-Promoting Bacteria 小麦氮肥与促生长细菌接种的交互作用

Biointerface Research in Applied Chemistry Pub Date : 2022-09-10 DOI: 10.33263/briac134.304

{"title":"Interactive Performance of Wheat Nitrogen Fertilization and Inoculation with Growth-Promoting Bacteria","authors":"","doi":"10.33263/briac134.304","DOIUrl":"https://doi.org/10.33263/briac134.304","url":null,"abstract":"The exploitation of plant growth-promoting rhizobacteria (PGPR) emerges as an important strategy for fixing atmospheric nitrogen (N) and making it available to plants. Correspondingly, the purpose of this study was to evaluate the inoculation with Azospirillum brasilense via foliar with distinct N doses (40, 20, and 0 kg/ha) for different wheat cultivars (Sossego, Toruk, and Quartzo). The experiment was conducted during the 2020 harvest at the State University of Rio Grande do Sul, Cachoeira do Sul, Brazil. A completely randomized design (CRD) in a 3x6 factorial scheme with four replications was applied. Yield components and grain yield were established. Furthermore, the physicochemical characterization of wheat siliqua biomass was executed based on subcritical water hydrolysis (SWH). Gluten and mass analysis was established. Appropriately, the grain yield was up to 3197.05 kg/ ha for the Sossego cultivar with the N dose of 40 kg/ ha. Up to 0.84 g reducing sugars/ 100 g wheat siliqua was obtained based on the SWH. Finally, this study promoted N management as a key factor in increasing grain yield. This scenario reports the importance of the association of PGPRs as a fundamental promoter of N for plants to express their maximum potential.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45979045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Docking, ADMET Prediction, and Quantum Computational on 2-Methoxy Benzoyl Hydrazone Compounds as Potential Antileishmanial Inhibitors 2-甲氧基苯甲酰腙化合物作为潜在抗癫痫抑制剂的分子对接、ADMET预测和量子计算

Biointerface Research in Applied Chemistry Pub Date : 2022-09-10 DOI: 10.33263/briac134.302

{"title":"Molecular Docking, ADMET Prediction, and Quantum Computational on 2-Methoxy Benzoyl Hydrazone Compounds as Potential Antileishmanial Inhibitors","authors":"","doi":"10.33263/briac134.302","DOIUrl":"https://doi.org/10.33263/briac134.302","url":null,"abstract":"Leishmaniasis is a neglected disease that affects about one million people a year worldwide and is present in over 90 countries. This illness is a serious public health issue since it can result in mutilation, incapacity, and even death. The drugs currently used for treatment are highly toxic, ineffective, expensive, and may cause antiparasitic resistance. A series of twenty-five 2-methoxy benzoyl hydrazone derivatives have recently been identified as promising antileishmanial inhibitors and was addressed using a molecular docking approach. All docked compounds interacted well within the active pocket of the receptor. Compounds M12, M15, M16, and M20 show a good binding energy value of -9.40, -8.90, -9.00, and -9.20 Kcal/mol, respectively, compared to pentamidine (-8.20 Kcal/mol), used as reference drug. These molecules also present many types and numbers of interactions with the studied receptor. The studied molecules were evaluated for their pharmacokinetic properties using ADMET prediction. They showed good bioavailability, particularly the molecules M12, M15, and M16 which were found to be non-toxic. Quantum calculations using the DFT approach were performed on the four selected compounds to determine the most electrophilic and nucleophilic of them. These findings would be very helpful in the search for new antileishmanial inhibitors.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44844109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the Antibiofilm Activity of Some Spices and Medicinal Plants Essential Oils 几种香料及药用植物精油抗菌活性的研究

Biointerface Research in Applied Chemistry Pub Date : 2022-09-08 DOI: 10.33263/briac134.301

引用次数: 0