Biointerface Research in Applied Chemistry最新文献

Endothelial and Hepatic Stellate Cells Conditioned Media Promote Hepatocyte-like Cell Differentiation and Functional Maturation of mESCs Cultured on 3D Scaffold 内皮细胞和肝星状细胞条件培养基促进三维支架培养间充质干细胞的肝细胞样细胞分化和功能成熟

Biointerface Research in Applied Chemistry Pub Date : 2025-11-14 DOI: 10.33263/briac156.090

Kshama Kumari, Prakash Baligar

{"title":"Endothelial and Hepatic Stellate Cells Conditioned Media Promote Hepatocyte-like Cell Differentiation and Functional Maturation of mESCs Cultured on 3D Scaffold","authors":"Kshama Kumari, Prakash Baligar","doi":"10.33263/briac156.090","DOIUrl":"https://doi.org/10.33263/briac156.090","url":null,"abstract":"Hepatocyte transplantation from stem cells holds a promising approach for treating liver failure, but inefficient differentiation into functional hepatocytes limits therapeutic applications. Recent research highlights the role of non-parenchymal cells, such as hepatic stellate cells (HSCs) and human umbilical vein endothelial cells (HUVECs), in supporting hepatocyte function through paracrine signaling. This study investigates the synergistic effects of HUVEC and HSC-conditioned media on the differentiation of mouse embryonic stem cells (mESCs) into hepatocyte-like cells (HLCs) by using a 3D gelatin scaffold. mESCs were cultured on a gelatin scaffold with conditioned media from HUVECs and HSCs (1:1:1), and differentiation was assessed through immunohistochemistry and gene expression analysis. Results showed that mouse embryonic stem cell-derived hepatocyte-like cells (mESC-HLCs) cultured with conditioned media exhibited increased expression of mature hepatic markers, including albumin, cytokeratin 18, and hepatocyte nuclear factor 4α, alongside markers of hepatoblasts and cholangiocytes. Functional assays demonstrated enhanced albumin secretion, creatinine production, and urea synthesis compared to cells treated with single conditioned media or standard differentiation media. These findings suggest that combining scaffold-based culture with niche-mimicking conditioned media effectively enhances hepatocyte differentiation, providing a promising approach for regenerative medicine and drug discovery applications.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":"15 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://doi.org/10.33263/briac156.090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147895540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endings and Beginnings: A Milestone for Biointerface Research in Applied Chemistry 结束与开始：应用化学生物界面研究的里程碑

Biointerface Research in Applied Chemistry Pub Date : 2024-12-15 DOI: 10.33263/briac146.151

{"title":"Endings and Beginnings: A Milestone for Biointerface Research in Applied Chemistry","authors":"","doi":"10.33263/briac146.151","DOIUrl":"https://doi.org/10.33263/briac146.151","url":null,"abstract":"Over the past decade, Biointerface Research in Applied Chemistry has established itself as a respected platform for sharing applied chemistry research. During this time, our headquarters was located at the National University of Science and Technology POLITEHNICA Bucharest under a commodatum agreement, which provided the necessary space for our journal’s operations. Recently, however, the administration of POLITEHNICA Bucharest decided not to renew this agreement. This decision was a surprise, especially since the university contacted me to submit the renewal request for the next cycle. Given the natural connection between universities and scientific journals—where journals help disseminate research and enhance the visibility of academic institutions—this turn of events was unexpected. Still, we respect that the university faces complex priorities and must make decisions it believes are best for its future. This transition is both a challenge and an opportunity. Despite relocation difficulties, we remain focused on advancing scientific research and providing platinum open access to knowledge. Our commitment is reinforced by the growing recognition of our work, as seen in the significant rise in our CiteScore from 4.8 in 2023 to 6.2 in 2024. This reflects increasing citations and global interest in the research we publish. As we close this chapter, we are grateful for this decade-long arrangement's foundation. While we move forward to new opportunities, we wish POLITEHNICA Bucharest success in their chosen direction. With optimism and determination, Biointerface Research in Applied Chemistry remains dedicated to supporting scientific innovation, serving the global research community, and publishing in a platinum open-access model for the past 14 years.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":"14 6","pages":"151-151"},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://doi.org/10.33263/briac146.151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147891038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physicochemical Improvement of Carvacrol Loaded Nanostructured Lipid Carrier (NLC) 香芹酚负载纳米结构脂质载体（NLC）的理化改进

Biointerface Research in Applied Chemistry Pub Date : 2024-10-15 DOI: 10.33263/briac145.107

引用次数: 0

Editorial. Thirteen Years of Free Publication: From the Optimistic Horizons to Failure and Discreditation 社论。自由出版十三年:从乐观的视野到失败和名誉扫地

Biointerface Research in Applied Chemistry Pub Date : 2023-04-23 DOI: 10.33263/briac141.001

引用次数: 0

Antibacterial Properties of Graphene and its Reinforcement Effect on Compressive Properties of PMMA 石墨烯的抗菌性能及其对PMMA压缩性能的增强作用

Biointerface Research in Applied Chemistry Pub Date : 2022-11-01 DOI: 10.33263/briac134.393

引用次数: 1

The Theoretical Description for Amavadin-Ion Electrochemical Determination in Amanita muscaria Mushroom Pulp and Extract by Galvanostatic Conducting Polymer Doping 恒电流导电聚合物掺杂法电化学测定鹅膏菌浆及提取物中阿玛丁的理论描述

Biointerface Research in Applied Chemistry Pub Date : 2022-11-01 DOI: 10.33263/briac134.400

引用次数: 0

Using Bio-Realistic Gaussian-Shaped Population and Dopamine-Modulated STDP for Training a Self-Balancing System 利用生物真实高斯型种群和多巴胺调制STDP训练自平衡系统

Biointerface Research in Applied Chemistry Pub Date : 2022-11-01 DOI: 10.33263/briac134.398

{"title":"Using Bio-Realistic Gaussian-Shaped Population and Dopamine-Modulated STDP for Training a Self-Balancing System","authors":"","doi":"10.33263/briac134.398","DOIUrl":"https://doi.org/10.33263/briac134.398","url":null,"abstract":"Human body balance is a gradual formation through repetition of actions, trial and error, and improving the mechanism of muscular-skeletal architecture for adapting to the demands of the environment. In the learning process, sensory receptors continuously send signals to the brain, then the brain to muscles and make a new signals pathway. Each time the body performs an action, millions of new synaptic connections are formed, and repetitive actions strengthen connections. So, a balanced body reuses the learned mechanism without performing any complex calculations. In contrast, the balance problem of a self-balancing robot has been solved by many different control algorithms. In this work, we propose a novel way to balance a two-wheeled self-balancing robot using bio-realistic Spiking Neural Networks (SNNs) to learn self-balancing, which is closely related to the way babies learn. To accomplish this, the gaussian shaped sensory neuronal population is connected with motor neurons through Spike-Timing-Dependent Plasticity (STDP) based synapses, further controlled with dopamine neurons. The key aspects of this approach are its bio-realistic nature and zero dependencies on data for adopting a new behavior compared to Deep Reinforcement Learning. Furthermore, this biologically-inspired mechanism can be used to improve the methodology for programming the robots to mimic Biological Intelligence.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45864591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Double Diffusion, Chemical Reaction, and Heat Source Effects on Magnetohydrodynamic Flow of Copper and Silver Water-based Nanofluids over a Moving Vertical Porous Plate 双扩散、化学反应和热源对铜和银水基纳米流体在移动的垂直多孔板上磁流体动力学流动的影响

Biointerface Research in Applied Chemistry Pub Date : 2022-11-01 DOI: 10.33263/briac134.394

{"title":"Double Diffusion, Chemical Reaction, and Heat Source Effects on Magnetohydrodynamic Flow of Copper and Silver Water-based Nanofluids over a Moving Vertical Porous Plate","authors":"","doi":"10.33263/briac134.394","DOIUrl":"https://doi.org/10.33263/briac134.394","url":null,"abstract":"In this manuscript, the impact of Soret and Dufour numbers on magnetohydrodynamic (MHD) flow for Silver (Ag) and Copper (Cu) water-based nanofluids past a moving plate over a porous medium are investigated numerically. The influences of heat sources and chemical reactions are also considered, as their applications are prevalent in several industries. The flow's constituents' governing equations are coupled with Partial differential equations (PDEs) that are converted into a dimensionless form using appropriate flow parameters. Subsequently, the finite-difference technique is used to resolve the resulting equations. The varied effects of flow parameters on the momentum, temperature, and concentration boundary layers are investigated using various graphs. The results presented in terms of non-dimensional parameters like shear stress factor, Sherwood number, and Nusselt number of fluids are tabulated for the nanofluids Ag-water and Cu-water. It is found that the augmented values of Dufour and Soret numbers enhance the fluid velocity. However, the species concentration decreases in the existence of Dufour and chemical reaction effects.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49060448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microstructure and Elastic Properties of Hydroxyapatite/Alumina Nanocomposites Prepared by Mechanical Alloying Technique for Biomedical Applications 机械合金化技术制备羟基磷灰石/氧化铝纳米复合材料的微观结构和弹性性能

Biointerface Research in Applied Chemistry Pub Date : 2022-11-01 DOI: 10.33263/briac134.395

{"title":"Microstructure and Elastic Properties of Hydroxyapatite/Alumina Nanocomposites Prepared by Mechanical Alloying Technique for Biomedical Applications","authors":"","doi":"10.33263/briac134.395","DOIUrl":"https://doi.org/10.33263/briac134.395","url":null,"abstract":"Although hydroxyapatite (HA) has exceptional biological qualities that inspire researchers to employ it as an appealing biomaterial for various purposes, its usage in hard tissue replacement applications is severely restricted because of its fragility. In order to create nanocomposites with the necessary mechanical properties for biomedical applications, HA was produced, and various amounts of alumina (Al2O3) were added to it. Additionally, the phase composition of the powdered nanocomposites was examined using the X-ray diffraction (XRD) technique. Crystal sizes, lattice strain, and dislocation density were all estimated as well. In order to measure the produced nanocomposite powders’ physical and elastic characteristics using the Archimedes method and ultrasonic non-destructive technique, they were then pressed and sintered at 1000 °C. The resulting information made it clear that further increases in the weight percentages of Al2O3 resulted in a 10.25, 25.64, and 33.33% reduction in crystal size. As a result of adding more Al2O3-up to 20 weight, percent-the results also showed that this properties-microhardness, compressive strength, Young’s modulus, elastic modulus, bulk modulus, shear modulus, and Poisson’s ratio-were improved by 109, 36.29, 95.5, 100.59, 104.97, 92.84 and 9.5%, respectively. Unfortunately, it increased its porosity by considerable amounts. It might be argued that the generated nanocomposites are favorable for biomedical applications.","PeriodicalId":9026,"journal":{"name":"Biointerface Research in Applied Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44190265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Poly(9-Vinylcarbazole)/Graphene Nanoheterostructure Interfaces: Ab Initio Dynamics Studies for Photovoltaic and Optoelectronic Applications 聚(9-乙烯基咔唑)/石墨烯纳米异质结构界面:光伏光电应用从头算动力学研究

Biointerface Research in Applied Chemistry Pub Date : 2022-11-01 DOI: 10.33263/briac134.399

引用次数: 0