A Review: Pharmacological Activities of Quinoline Alkaloid of Cinchona sp.

Q3 Biochemistry, Genetics and Molecular Biology

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI:10.33263/briac134.319

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引用次数: 2

Abstract

Cinchona is a plant used in traditional malaria treatment. This review aims to examine pharmacological activities to increase the benefits and uses of the bioactive compounds found in the bark of the Cinchona trees as medicine and cosmetics. A literature search was conducted through the internet database https://pubmed.ncbi.nlm.nih.gov/; https://scholar.google.com/; https://www.sciencedirect.com/; https://www.wiley.com/en-us from 1998-2022. The main phytochemical content of Cinchona bark is quinoline alkaloids (quinine, cinchonidine, cinchonine, and cinchonidine), with total alkaloid concentrations varying between 6 and 15% (Cinchona succirubra ranging from 5-7%, Cinchona calisaya 4-7% and Cinchona ledgeriana 5-14%). Cinchona quinoline alkaloids have the same active site on the nitrogen atom in the quinuclidine ring and the methylene alcohol functional group, which plays an essential role in their pharmacological activity. Besides being used as an antimalarial, Cinchona alkaloids are currently being developed as their anticancer, antioxidant, antidiabetic, antifungal, muscle cramps, hair growth stimulant, antimicrobial, antiobesity, antiplatelet, antiviral, anesthetic, and antipyretic properties. Conclusion: Quinoline alkaloids of Cinchona sp have various pharmacological activities that have the potency to be developed as drugs and cosmetics.

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金鸡纳喹啉生物碱的药理活性研究进展。

金鸡纳是一种用于传统疟疾治疗的植物。本综述旨在研究金鸡纳树皮中生物活性物质的药理活性，以增加其作为药物和化妆品的益处和用途。通过互联网数据库https://pubmed.ncbi.nlm.nih.gov/进行文献检索;https://scholar.google.com/;https://www.sciencedirect.com/;https://www.wiley.com/en-us从1998年到2022年。金鸡纳树皮的主要植物化学成分为喹啉类生物碱(奎宁、金鸡尼定、金鸡宁、金鸡尼定)，总生物碱含量在6% ~ 15%之间(金鸡纳为5 ~ 7%，金鸡纳为4 ~ 7%，金鸡纳为5 ~ 14%)。金鸡纳喹啉类生物碱在喹啉环的氮原子上与亚甲基醇官能团具有相同的活性位点，这对其药理活性起着至关重要的作用。除了用于抗疟疾，金鸡纳生物碱目前被开发为抗癌、抗氧化、抗糖尿病、抗真菌、肌肉痉挛、促进毛发生长、抗菌、抗肥胖、抗血小板、抗病毒、麻醉和解热的特性。结论:金鸡纳的喹啉类生物碱具有多种药理活性，具有开发药用和化妆品的潜力。

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来源期刊

Biointerface Research in Applied Chemistry CHEMISTRY, APPLIED-

CiteScore

4.80

自引率

0.00%

发文量

256

期刊介绍： Biointerface Research in Applied Chemistry is an international and interdisciplinary research journal that focuses on all aspects of nanoscience, bioscience and applied chemistry. Submissions are solicited in all topical areas, ranging from basic aspects of the science materials to practical applications of such materials. With 6 issues per year, the first one published on the 15th of February of 2011, Biointerface Research in Applied Chemistry is an open-access journal, making all research results freely available online. The aim is to publish original papers, short communications as well as review papers highlighting interdisciplinary research, the potential applications of the molecules and materials in the bio-field. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible.