The Role of Fibronectin and its Isoforms in the Pathogenesis and Progression of Rheumatoid Arthritis: A Review

Q3 Biochemistry, Genetics and Molecular Biology

Biointerface Research in Applied Chemistry Pub Date : 2022-09-11 DOI:10.33263/briac134.341

引用次数: 2

Abstract

Rheumatoid arthritis (RA) remains a desolating and devastating disease with a strong social impact on the world. Current drugs and therapies are showing poor responses toward RA due to its unknown progression. Evidence has shown that Extra Domain A fibronectin, recognized as a damage-associated molecular pattern (DAMPs), interacts with pathogen recognition receptors (PRR), which play a vital role in the erosion and degradation of joints. The post-translational modification and citrullination of fibronectin enhance the expression of EDA fibronectin (EDA+Fn). Fibronectin and its interacting receptors, such as TLR-4 may be a potential target for the treatment of RA. This review critically summarizes the recent discoveries and breakthroughs in the role of fibronectin and its isoforms in the pathogenesis and progression of RA.

查看原文本刊更多论文

纤维连接蛋白及其异构体在类风湿性关节炎发病机制和进展中的作用

类风湿性关节炎(RA)仍然是一种令人荒凉和毁灭性的疾病，对世界产生了强烈的社会影响。由于病情进展不明，目前的药物和疗法对类风湿关节炎的疗效不佳。有证据表明，额外结构域A纤维连接蛋白被认为是一种损伤相关分子模式(DAMPs)，它与病原体识别受体(PRR)相互作用，在关节的侵蚀和降解中起着至关重要的作用。纤维连接蛋白的翻译后修饰和瓜氨酸化增强了EDA纤维连接蛋白(EDA+Fn)的表达。纤维连接蛋白及其相互作用受体，如TLR-4可能是治疗RA的潜在靶点。本文综述了纤维连接蛋白及其亚型在类风湿关节炎发病和进展中的作用的最新发现和突破。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Biointerface Research in Applied Chemistry CHEMISTRY, APPLIED-

CiteScore

4.80

自引率

0.00%

发文量

256

期刊介绍： Biointerface Research in Applied Chemistry is an international and interdisciplinary research journal that focuses on all aspects of nanoscience, bioscience and applied chemistry. Submissions are solicited in all topical areas, ranging from basic aspects of the science materials to practical applications of such materials. With 6 issues per year, the first one published on the 15th of February of 2011, Biointerface Research in Applied Chemistry is an open-access journal, making all research results freely available online. The aim is to publish original papers, short communications as well as review papers highlighting interdisciplinary research, the potential applications of the molecules and materials in the bio-field. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible.