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Detection of Vitiligo Through Machine Learning and Computer-Aided Techniques: A Systematic Review. 通过机器学习和计算机辅助技术检测白癜风:系统综述。
IF 2.6 3区 生物学
BioMed Research International Pub Date : 2024-12-19 eCollection Date: 2024-01-01 DOI: 10.1155/bmri/3277546
Sania Tanvir, Sidra Abid Syed, Samreen Hussain, Razia Zia, Munaf Rashid, Hira Zahid
{"title":"Detection of Vitiligo Through Machine Learning and Computer-Aided Techniques: A Systematic Review.","authors":"Sania Tanvir, Sidra Abid Syed, Samreen Hussain, Razia Zia, Munaf Rashid, Hira Zahid","doi":"10.1155/bmri/3277546","DOIUrl":"10.1155/bmri/3277546","url":null,"abstract":"<p><p><b>Background and Objective:</b> Vitiligo is a chronic skin damage disease, triggered by differential melanocyte death. Vitiligo (0.5%-1% of the population) is one of the most severe skin conditions. In general, the foundation of the condition of vitiligo remains gradual patchy loss of skin pigmentation, overlying blood, and sometimes mucus. This paper provides a systematic review of the relevant publications and conference papers based on the subject of vitiligo diagnosis and confirmation through computer-aided machine learning (ML) techniques. <b>Materials and Methods:</b> A search was conducted using a predetermined set of keywords across three databases, namely, Science Direct, PubMed, and IEEE Xplore. The selection process involved the application of eligibility criteria, which led to the inclusion of research published in reputable journals and conference proceedings up until June 2024. These selected papers were then subjected to full-text screening for additional analysis. Research publications that involved application of ML techniques with targeted population of vitiligo were selected for further systematic review. <b>Results:</b> Ten selected and screened studies are included in this systematic review after applying eligibility criteria along with inclusion and exclusion criteria applied on initial search result which was 244 studies based on vitiligo. Priority is given to those studies only which use ML techniques to perform detection and diagnosis on vitiligo-targeted population. Data analysis was carried out only from the selected and screened research articles that were published in authentic journals and conference proceedings. <b>Conclusion:</b> The importance of applying ML techniques in the clinical diagnosis of vitiligo can give more accurate results and at the same also eliminate the need of biased human judgement. Based on a comprehensive examination of the research, encompassing the methodologies employed and the metrics utilized to assess outcomes, it was determined that there is a need for further research and investigation regarding the application of ML algorithm for the detection and diagnosis of vitiligo with different datasets and more feature extraction.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"3277546"},"PeriodicalIF":2.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Intelligence and Its Revolutionary Role in Physical and Mental Rehabilitation: A Review of Recent Advancements. 人工智能及其在身心康复中的革命性作用:最新进展综述。
IF 2.6 3区 生物学
BioMed Research International Pub Date : 2024-12-17 eCollection Date: 2024-01-01 DOI: 10.1155/bmri/9554590
Amir Rahmani Rasa
{"title":"Artificial Intelligence and Its Revolutionary Role in Physical and Mental Rehabilitation: A Review of Recent Advancements.","authors":"Amir Rahmani Rasa","doi":"10.1155/bmri/9554590","DOIUrl":"10.1155/bmri/9554590","url":null,"abstract":"<p><p>The integration of artificial intelligence (AI) technologies into physical and mental rehabilitation has the potential to significantly transform these fields. AI innovations, including machine learning algorithms, natural language processing, and computer vision, offer occupational therapists advanced tools to improve care quality. These technologies facilitate more precise assessments, the development of tailored intervention plans, more efficient treatment delivery, and enhanced outcome evaluation. This review explores the integration of AI across various aspects of rehabilitation, providing a thorough examination of recent advancements and current applications. It highlights how AI applications, such as natural language processing, computer vision, virtual reality, machine learning, and robotics, are shaping the future of physical and mental recovery in occupational therapy.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"9554590"},"PeriodicalIF":2.6,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioinformatics Analysis of Biomarkers and Therapeutic Targets Related to Necroptosis in Intervertebral Disc Degeneration. 椎间盘退变坏死性下垂相关生物标志物和治疗靶点的生物信息学分析。
IF 2.6 3区 生物学
BioMed Research International Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.1155/bmri/9922966
Fan Zhang, Lei Yuan, Heng Ding, Zhenkai Lou, Xingguo Li
{"title":"Bioinformatics Analysis of Biomarkers and Therapeutic Targets Related to Necroptosis in Intervertebral Disc Degeneration.","authors":"Fan Zhang, Lei Yuan, Heng Ding, Zhenkai Lou, Xingguo Li","doi":"10.1155/bmri/9922966","DOIUrl":"10.1155/bmri/9922966","url":null,"abstract":"<p><p>Necroptosis is a critical process in intervertebral disc degeneration (IDD). This research is aimed at identifying key genes regulating necroptosis in IDD to provide a theoretical basis for early diagnosis and treatment. Transcriptome data from patients with IDD and normal samples were obtained from the GSE34095 and GSE124272 datasets of the Gene Expression Omnibus (GEO) public database. Necroptosis-related genes (NRGs) were sourced from the GeneCards database and literature. Differentially expressed necroptosis-related genes (DE-NRGs) in IDD were identified by intersecting these sources. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were used for gene annotation analysis. The receiver operating characteristic (ROC) curve and nomogram analyses assessed the diagnostic efficiency of DE-NRGs. The miRWalk and starBase databases helped construct the competing endogenous RNA (ceRNA) regulatory network of DE-NRGs. We identified 517 differential genes in tissue and 2974 in blood, with 62 genes in common. DE-NRGs (<i>AIFM1</i>, <i>CCT8</i>, <i>HNRNPA1</i>, <i>KHDRBS1</i>, <i>SERBP1</i>) were identified by intersecting NRGs with these 62 common genes. The ROC curve showed an area under the curve (AUC) > 0.70 for DE-NRGs, and the nomogram indicated that a higher DE-NRG score correlates with a higher risk of IDD. <i>CCT8</i>, <i>KHDRBS1</i>, and <i>AIFM1</i> emerged as potential therapeutic targets for IDD through target drug prediction. qRT-PCR (quantitative reverse transcription polymerase chain reaction), Western blot, and immunohistochemistry confirmed the expression of <i>AIFM1</i>, <i>CCT8</i>, <i>HNRNPA1</i>, <i>KHDRBS1</i>, and <i>SERBP1</i> in patients' nucleus pulposus tissue, suggesting these genes as key targets for IDD risk assessment and drug therapy.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"9922966"},"PeriodicalIF":2.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MRI-Based Morphometric Comparison of Lower Leg Muscles and Tendons in Individuals With Medial Tibial Stress Syndrome. 胫骨内侧应激综合征患者下肢肌肉和肌腱的mri形态学比较。
IF 2.6 3区 生物学
BioMed Research International Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.1155/bmri/8827692
Lucas Nogueira de Oliveira, João Luiz Quagliotti Durigan, Caroline Ribeiro Sanchez, Henrique Mansur, Andressa Beatriz Beltrão Rosa, Rita de Cássia Marqueti
{"title":"MRI-Based Morphometric Comparison of Lower Leg Muscles and Tendons in Individuals With Medial Tibial Stress Syndrome.","authors":"Lucas Nogueira de Oliveira, João Luiz Quagliotti Durigan, Caroline Ribeiro Sanchez, Henrique Mansur, Andressa Beatriz Beltrão Rosa, Rita de Cássia Marqueti","doi":"10.1155/bmri/8827692","DOIUrl":"10.1155/bmri/8827692","url":null,"abstract":"<p><p>Runners frequently suffer from medial tibial stress syndrome (MTSS), often linked to excessive eccentric muscle contractions causing periosteal traction by the muscles in the deep posterior compartment. However, the effects of MTSS on these muscles and tendons remain underexplored. This study is aimed at investigating changes in muscle and tendon volumes in this compartment, as well as cross-sectional area measurements, using magnetic resonance imaging. Thirty individuals were divided into two groups: MTSS (<i>n</i> = 18; mean age 30.3 ± 12.4) and control (<i>n</i> = 12; age 35.2 ± 9.2). The anterior, deep posterior, superficial posterior, and lateral compartment muscles, along with their respective tendons, were compared between groups, and possible sex differences were also evaluated. The deep posterior compartment showed a significant volume difference of 0.41 cm<sup>3</sup>/kg<sup>3</sup>/<sup>4</sup> in the MTSS group (<i>p</i> = 0.034), primarily due to the flexor hallucis longus (FHL), which had a 0.55 cm<sup>3</sup>/kg<sup>3</sup>/<sup>4</sup> greater normalized volume (17.12% greater mean muscle volume) compared to controls (<i>p</i> = 0.023; Cohen <i>d</i> = 0.895). No association between sex and MTSS was found (<i>p</i> = 0.752). In conclusion, the FHL muscle exhibited increased normalized volume in the MTSS group compared to controls, with no sex-related differences in MTSS. Clinicians should consider the assessment of FHL muscle volume in routine evaluations of patients presenting with symptoms suggestive of MTSS.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"8827692"},"PeriodicalIF":2.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Antimicrobial and Anti-Biofilm Activities of Thymus fallax Essential Oil against Oral Pathogens". “胸腺精油对口腔病原体的抗菌和抗生物膜活性”的勘误表。
IF 2.6 3区 生物学
BioMed Research International Pub Date : 2024-12-13 eCollection Date: 2024-01-01 DOI: 10.1155/bmri/9797835
Maryam Moshaverinia, Sarina Sahmeddini, Fatemeh Lavaee, Zahra Zareshahrabadi, Kamiar Zomorodian
{"title":"Corrigendum to \"Antimicrobial and Anti-Biofilm Activities of <i>Thymus fallax</i> Essential Oil against Oral Pathogens\".","authors":"Maryam Moshaverinia, Sarina Sahmeddini, Fatemeh Lavaee, Zahra Zareshahrabadi, Kamiar Zomorodian","doi":"10.1155/bmri/9797835","DOIUrl":"10.1155/bmri/9797835","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/2022/9744153.].</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"9797835"},"PeriodicalIF":2.6,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Impact of Biological Agents on Protecting Against Experimental Periodontitis: A Systematic Review of Animal-Based Studies. 探索生物制剂对实验性牙周炎的保护作用:基于动物研究的系统综述。
IF 2.6 3区 生物学
BioMed Research International Pub Date : 2024-12-02 eCollection Date: 2024-01-01 DOI: 10.1155/bmri/1716735
Gabriela Ezequiel Oliveira, Davi da Silva Barbirato, Bruna Silva de Menezes, Milenna Silva Fuly, Henrique Cassebe Ledo Pelegrine, Debora Caliendo Bonilha, Julia Gabrielle Pereira de Alencar, Leticia Helena Theodoro, Rafael Scaf de Molon
{"title":"Exploring the Impact of Biological Agents on Protecting Against Experimental Periodontitis: A Systematic Review of Animal-Based Studies.","authors":"Gabriela Ezequiel Oliveira, Davi da Silva Barbirato, Bruna Silva de Menezes, Milenna Silva Fuly, Henrique Cassebe Ledo Pelegrine, Debora Caliendo Bonilha, Julia Gabrielle Pereira de Alencar, Leticia Helena Theodoro, Rafael Scaf de Molon","doi":"10.1155/bmri/1716735","DOIUrl":"10.1155/bmri/1716735","url":null,"abstract":"<p><p><b>Aim:</b> This systematic review was aimed at addressing the focused question: What is the protective potential of biological agents against alveolar bone resorption during the progression of experimental periodontitis (EP)? <b>Material and Methods:</b> The study protocol was registered in the Open Science Framework database (doi:10.17605/OSF.IO/3P2HY). A comprehensive literature search was conducted across PubMed, Web of Science, Cochrane Library, Scopus, and Embase databases up to December 2023. Inclusion criteria consisted of preclinical studies in animal models of EP that examined the effects of biological agents on preventing periodontal bone loss and reducing tissue inflammation. Studies were excluded if they (i) used non-EP animal models; (ii) focused on antimicrobial agents; (iii) centered on prebiotics or probiotics; (iv) evaluated compounds not classified as biologicals; or (v) included randomized clinical trials, clinical studies, or reviews. Eligibility was determined based on the PI/ECOs framework, and study quality was assessed using the SYRCLE risk-of-bias tool. <b>Results:</b> After screening an initial pool of 5236 records from databases, registries, and hand searches, 39 studies met the inclusion criteria. A total of 23 biological agents were evaluated across these studies. The majority of studies employed the ligature-induced model of EP to test the effectiveness of biologicals as preventive or therapeutic interventions. The dosage of biological agents and the duration of disease induction varied depending on the EP model. In all studies, the main outcome-alveolar bone loss, a hallmark of EP-was significantly inhibited by biological agents, which also reduced proinflammatory mediators when compared to untreated controls. A key strength of this review is the high number of studies included, most of which were classified as having low risk of bias. However, a notable limitation is the absence of a meta-analysis, the short follow-up periods in the included studies, and the heterogeneity among the compound dosages and route of administration. <b>Conclusion:</b> This systematic review demonstrates that biological agents are effective in reducing bone loss and mitigating inflammation during EP progression. Randomized clinical trials are needed to confirm these findings in human populations.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"1716735"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Induction of Innate Immune Memory in LPS-Primed Microglial Cells by Water-Soluble Chitosan. 水溶性壳聚糖诱导脂多糖诱导的小胶质细胞先天免疫记忆。
IF 2.6 3区 生物学
BioMed Research International Pub Date : 2024-11-30 eCollection Date: 2024-01-01 DOI: 10.1155/bmri/8027006
Vo Thuy Anh Thu, Thi Xoan Hoang, Jae Kweon Park, Jae Young Kim
{"title":"Induction of Innate Immune Memory in LPS-Primed Microglial Cells by Water-Soluble Chitosan.","authors":"Vo Thuy Anh Thu, Thi Xoan Hoang, Jae Kweon Park, Jae Young Kim","doi":"10.1155/bmri/8027006","DOIUrl":"10.1155/bmri/8027006","url":null,"abstract":"<p><p>Innate immune memory or trained immunity refers to a long-lasting response of the innate immune cells against repeated exposure to the homogenous or heterogenous infectious agent. The trained immunity is induced through epigenetic modification and is characterized by the change of both intracellular immunological signaling and cellular metabolism. Recently, different groups have tried to establish protocols to generate trained innate immune cells. However, the molecular basis of innate memory induction remains poorly understood. Here, we evaluated the impact of water-soluble chitosan on the innate immune memory induction in microglial cells primed with LPS. The trained-immune response was accessed by measuring proinflammatory markers, metabolic change, and epigenetic modification. We showed that the stimulation/restimulation with LPS only caused a robust reduction of iNOS, and proinflammatory cytokines, indicating induced immune tolerance. In contrast, the treatment of chitosan induces long-lasting memory microglial cells accompanied by a high level of iNOS, increased lactate production, induced epigenetic modification, and the upregulation of proinflammatory cytokines upon further exposure to the same stimulus. These findings suggest that chitosan induces microglial-trained immunity by targeting distinct epigenetic and metabolic pathways; therefore, chitosan treatment may provide a novel approach for targeting innate immunity towards a memory-like response in an in vitro model.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"8027006"},"PeriodicalIF":2.6,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Gut Microbiomes Between Neonates Born by Cesarean Section and Vaginal Delivery: Prospective Observational Study. 剖宫产和阴道分娩新生儿肠道微生物组的比较:前瞻性观察研究。
IF 2.6 3区 生物学
BioMed Research International Pub Date : 2024-11-28 eCollection Date: 2024-01-01 DOI: 10.1155/bmri/8302361
Nichapat Pahirah, Amarin Narkwichean, Malai Taweechotipatr, Sivaporn Wannaiampikul, Chinpanee Duang-Udom, Wipada Laosooksathit
{"title":"Comparison of Gut Microbiomes Between Neonates Born by Cesarean Section and Vaginal Delivery: Prospective Observational Study.","authors":"Nichapat Pahirah, Amarin Narkwichean, Malai Taweechotipatr, Sivaporn Wannaiampikul, Chinpanee Duang-Udom, Wipada Laosooksathit","doi":"10.1155/bmri/8302361","DOIUrl":"10.1155/bmri/8302361","url":null,"abstract":"<p><p><b>Background:</b> Balanced diversity and abundance of gut microbiome play important roles in human health, including neonatal health. Though not established, there is evidence that the delivery route could alter the diversity of neonatal gut microbiomes. <b>Objective:</b> The objective of the study was to investigate the differences in the gut microbiomes of neonates delivered via cesarean section compared to those born by vaginal delivery and to identify the predominant microbial taxa present in each group. <b>Study Design:</b> A prospective observational study of 281 healthy neonates born between February 2021 and April 2023 at Her Royal Highness Maha Chakri Sirindhorn Medical Center, Srinakharinwirot University, Thailand, was performed. The study population was divided into two groups: 139 neonates born via vaginal delivery and 141 neonates born via cesarean section. The microbiota composition of each neonate's fecal sample was identified by using 16S ribosomal ribonucleic acid metagenomic sequencing. <b>Results:</b> Neonates delivered vaginally exhibited a gut microbiome with higher abundance and diversity than those delivered by cesarean delivery. <i>Bifidobacterium</i> was the dominant genus in both groups. <i>Bifidobacterium breve</i> was the dominant species and was significantly higher in cesarean-delivered neonates compared to those delivered vaginally (24.0% and 9.2%, respectively) (<i>p</i> < 0.001). However, the taxonomy of only 89 (64.0%) and 44 (31.43%) fecal samples could be identified from the vaginal and cesarean delivery groups, respectively. <b>Conclusion:</b> Route of delivery is associated with neonatal gut microbiome abundance and diversity. Neonates delivered via vaginal delivery exhibited higher diversity but lower abundance of the dominant species in the gut microbiome. <b>Trial Registration:</b> Thai Clinical Trials Registry identifier: TCTR20221024003.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"8302361"},"PeriodicalIF":2.6,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Indigenous Knowledge and Quantitative Analysis of Medicinal Plants Used to Remedy Respiratory Tract Disorders in Mid-Western Tanzania. 坦桑尼亚中西部用于治疗呼吸道疾病的药用植物的土著知识和定量分析。
IF 2.6 3区 生物学
BioMed Research International Pub Date : 2024-11-28 eCollection Date: 2024-01-01 DOI: 10.1155/bmri/8534815
David Sylvester Kacholi, Halima Mvungi Amir
{"title":"Indigenous Knowledge and Quantitative Analysis of Medicinal Plants Used to Remedy Respiratory Tract Disorders in Mid-Western Tanzania.","authors":"David Sylvester Kacholi, Halima Mvungi Amir","doi":"10.1155/bmri/8534815","DOIUrl":"10.1155/bmri/8534815","url":null,"abstract":"<p><p>This study is aimed at documenting the indigenous knowledge and quantitative analysis of medicinal plants (MPs) used by traditional health practitioners (THPs) of Urambo District in mid-western Tanzania to manage respiratory tract disorders (RTDs). The ethnomedicinal data were collected using semistructured interviews with 55 THPs using a snowballing technique in the district. The data were analysed for indigenous knowledge among gender, age groups, education status, and experience. Family importance value (FIV), use value (UV), relative frequency of citation (RFC), informant consensus factor (ICF), and Jaccard index (JI) were computed. A total of 42 MPs representing 28 families were recorded being used against RTDs in the district. Fabaceae was the dominant family in terms of species (16.7%) and FIV (84%). Decoction (51.0%) was the preferred technique for preparing remedies, while trees (61.9%) and leaves (38.1%) were the most utilised life form and plant parts, respectively. The RFC in the current study varied from 0.055 (<i>Musa paradisiaca</i> L.) to 0.655 (<i>Zingiber officinale</i> Roscoe) and 0.073 (<i>Dichrostachys cinerea</i> (L.) Wight & Arn.) to 0.673 (<i>Entada abyssinica</i> Steud. ex A.Rich.), respectively. The highest ICF was recorded for cough (0.922). The JI ranged from 2.7 to 7.9. Among the documented MPs, 55% had least concern, 2% were endangered, 7% had data deficiency conservation status, and 36% had no record in the IUCN Red List. The study revealed that the district's population depends on MPs for healthcare. Thus, conservation strategies are needed for the sustainable utilisation of the MPs. Importantly, the documented MPs hold immense potential in future pharmacological and phytochemical studies, offering hope for the development of new drugs for RTDs. Also, the study suggests the need for scientific validation of the MP's efficacy and safety.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"8534815"},"PeriodicalIF":2.6,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biodegradation Study of Biomaterials Composed of Acrylated Epoxidized Soybean Oil: An In Vitro Study. 丙烯酸基环氧大豆油生物材料的体外降解研究
IF 2.6 3区 生物学
BioMed Research International Pub Date : 2024-11-22 eCollection Date: 2024-01-01 DOI: 10.1155/bmri/7100988
Diego Sibilia, Martina Amendolea, Roberta Sangiovanni, Mario Bragaglia, Fabrizio Nicoletti, Pierfrancesco Filetici, Antonio D'Addona, Francesca Nanni, Leonardo Dassatti, Giuseppina Nocca
{"title":"Biodegradation Study of Biomaterials Composed of Acrylated Epoxidized Soybean Oil: An In Vitro Study.","authors":"Diego Sibilia, Martina Amendolea, Roberta Sangiovanni, Mario Bragaglia, Fabrizio Nicoletti, Pierfrancesco Filetici, Antonio D'Addona, Francesca Nanni, Leonardo Dassatti, Giuseppina Nocca","doi":"10.1155/bmri/7100988","DOIUrl":"https://doi.org/10.1155/bmri/7100988","url":null,"abstract":"<p><p>In the field of regenerative medicine, acrylated epoxidized vegetable oils are emerging as a promising avenue of exploration. The aim of this study is to evaluate the degradability of two formulations of acrylated epoxidized soybean oil (AESO): pure AESO and AESO diluted with soybean oil (SO) for potential bioprintability applications. The comprehensive investigation of these two polymeric formulations included optimization of polymerization conditions, confirmation of cytocompatibility, and, most importantly, the study of their degradability. The results reveal that AESO, used as a biomaterial for biomedical applications, undergoes a distinctive degradation process, combining both enzymatic and oxidative degradation (AESO/SO samples lose 29.45% of their weight after 60 days). This phenomenon is the result of a complex interplay of factors, including the chemical composition and physical characteristics of the polymer, the unique tissue environment in which it is implanted, and the duration of implantation.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"7100988"},"PeriodicalIF":2.6,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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