BioMed Research International最新文献

{"title":"Assessment of Health-Related Quality of Life and Its Associated Factors Among Cardiovascular Disease Patients at a Teaching Hospital in Northwest Ethiopia: A Cross-Sectional Study.","authors":"Assefa Belay Asrie, Mulugeta Dereje, Amanuel Getachew, Betelhem Genetu","doi":"10.1155/bmri/1159456","DOIUrl":"https://doi.org/10.1155/bmri/1159456","url":null,"abstract":"<p><p><b>Background:</b> Health-related quality of life (HRQoL) has become a widely recognized outcome measure to assess the impact of illnesses or effectiveness of treatments. This study was carried out to investigate HRQoL and associated factors among cardiovascular disease patients. <b>Method:</b> This is a cross-sectional study and was carried out from July 01 to August 30, 2021. The patients were recruited using systematic random sampling technique and data was collected using EQ-5D five-level (EQ-5D-5L) questionnaires and EQ visual analog scale (EQ VAS). Utility index values were calculated using disutility weights set in Ethiopian context. Mann-Whitney <i>U</i> and Kruskal-Wallis tests were employed to compare the median index values and EQ VAS scores across subgroups. Tobit regression analysis was performed to determine factors associated with HRQoL. <b>Results:</b> Performing usual activities (76.8%) and pain/discomfort (74.9%) were the first and the second dimensions of most frequently reported health problems, respectively. The overall median (interquartile range) EQ-5D-5L index value and VAS score were 0.82 (0.65-0.92) and 70.0 (60.0-80.0), respectively. Older age, multiple CVD diagnoses, and adherence problems to medications were found to be negatively associated with HRQoL. <b>Conclusion:</b> In conclusion, performing usual activities and pain/discomfort were the dimensions with the most frequently reported problems. This finding dictates the importance of giving special attention to these dimensions in managing CVD patients. Besides, older age, multiple CVDs, and nonadherence to medications were negatively associated with HRQoL. Thus, acting in consideration of these factors in patient management may have positive implications in improving their HRQoL.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"1159456"},"PeriodicalIF":2.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11991770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cloning and Recombinant Expression of the Caspase-Activated DNase Orthologous Gene of <i>Giardia lamblia</i>.","authors":"María Cristina Villa-Medina, Cecilia Díaz-Gaxiola, Roberto Rosales-Reyes, Sergio Alonso Durán-Pérez, Ulises Vega-Castillo, Jesús Alberto Rodríguez-Rochín, Claudia Del Rosario León-Sicairos, Evangelina Beltrán-López, Héctor Samuel López-Moreno","doi":"10.1155/bmri/3420875","DOIUrl":"https://doi.org/10.1155/bmri/3420875","url":null,"abstract":"<p><p>In eukaryotic cells, mitochondria play a key role in apoptosis; however, ancestral eukaryotic cells such as <i>Giardia lamblia</i> only possess a mitochondrial remnant, the mitosome. Interestingly, this protozoan still undergoes an apoptosis-like process; therefore, we focused primarily on the search for the mitochondria-independent executor DNase. Here, we identified, cloned, expressed, and characterized the caspase-activated DNase (CAD) from <i>Giardia lamblia</i>. Using a commercial polyclonal antibody that recognizes mouse, rat, and human caspase-activated DNase (hCAD), we developed an immunoproteomic analysis using a crude extract of curcumin-treated <i>Giardia lamblia</i> trophozoites (CEGl) and detected a spot of 42 kDa and pI 9.4, similar to hCAD and sequenced by LC-MS. The proteomic profile matched a novel protein of 383 residues, with a predicted 42 kDa, pI 9.4, a CIDE-N domain, and putative H-K-H catalytic motif. Afterward, we cloned the full-length gene (GenBank: ON707040), expressed it, and purified it as a 6-His tag-recombinant protein in <i>Escherichia coli</i>, which was also recognized by commercial anti-CAD. In conclusion, genetic, proteomic, and structural analyses showed that the identified gCAD is an orthologous protein of hCAD, and its DNase role in the apoptosis-like signaling pathway of <i>Giardia lamblia</i> can be further analyzed.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"3420875"},"PeriodicalIF":2.6,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11991804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between Propulsive Velocity, Maximum Velocity, and Power and the 2D:4D Ratio in Paralympic Powerlifting Athletes.","authors":"Álvaro Fontes da Silva Neto, Felipe J Aidar, Ângelo de Almeida Paz, Jymmys L Santos, Raphael Fabricio de Souza, Paulo Francisco de Almeida-Neto, Koulla Parpa, Breno Guilherme de Araújo Tinoco Cabral, Anderson Carlos Marçal, Georgian Badicu","doi":"10.1155/bmri/8701719","DOIUrl":"https://doi.org/10.1155/bmri/8701719","url":null,"abstract":"<p><p><b>Background:</b> Among the strength sports we have Paralympic powerlifting, and the factors that influence strength have been investigated; among them is the relationship between strength and the ratio of the size of the second and fourth fingers of the hand (2D:4D). <b>Objectives:</b> The study is aimed at evaluating the relationship between the 2D:4D finger length ratio and the dynamic strength indicators, mean propulsive velocity (MPV), maximum velocity (Vmax), and power, with loads of 45% and 80% of one repetition maximum (1RM), in Paralympic powerlifting. <b>Methodology:</b> Sixteen elite Paralympic powerlifting athletes were evaluated for dynamic strength indicators, MPV, Vmax, and power, with loads of 45% and 80% 1RM. The 2D:4D proportions and correlations between the indicators were evaluated of 2D:2D ratios and dynamic strength indicators. <b>Results:</b> Moderate correlations were found between MPV 45% and 4D (<i>r</i> = 0.551, <i>p</i> = 0.027), between MPV 45% and R-L 2D:4D diff. (<i>r</i> = -0.595, <i>p</i> = 0.015), between power 80% and L2 (<i>r</i> = 0.542, <i>p</i> = 0.030), and between MPV 45% and R-L 2D:4D (<i>r</i> = -0.585, <i>p</i> = 0.017). There was also a moderate correlation between power 80% left 2D (<i>r</i> = -0.542, <i>p</i> = 0.030). However, no correlation was found between the 2D:4D ratios and dynamic strength indicators in Paralympic powerlifting. <b>Conclusion:</b> The 2D:4D ratio presents a moderate correlation with dynamic strength indicators in Paralympic powerlifting athletes, where the ratios with the velocity of 45 of 1RM can be used as a predictor but with caution.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"8701719"},"PeriodicalIF":2.6,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11991830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of UCOE and HSP27 Molecular Elements to Improve the Stable Protein Production on HEK293 Cells.","authors":"Concepción Sosa-García, Uriel Abdallah Sánchez-Pacheco, Carlos Alberto Tavira-Montalvan, Angélica Meneses-Acosta","doi":"10.1155/bmri/5556353","DOIUrl":"10.1155/bmri/5556353","url":null,"abstract":"<p><p>Recombinant proteins represent one of the greatest achievements of modern pharmaceutical biotechnology, as they are increasingly used across nearly all branches of medicine to treat a wide range of conditions. In response to this demand, various cell engineering approaches have been developed to improve their expression. Some of these approaches involve the use of genetic elements that prevent the silencing of the gene of interest, as well as the generation of resistant cell lines to inhibit or avoid programmed cell death (PCD). This research focuses on analyzing the effects of overexpression of UCOE elements and the HSP27 protein, both individually and together, on the production of human rIFN<i>γ</i> in HEK293 cells. Our results show that 4-Kb UCOE elements have no effect on protein production in HEK293 cells, while overexpression of HSP27 prolongs the stationary phase during growth kinetics. The Qp of rIFN<i>γ</i> is 96-fold higher in clones containing the HSP27/UCOE combination compared to the clone containing only UCOE elements or to the control HEK293 cells. These results correlate with the MCP analyses, which showed that overexpression of HSP27 decreased the expression of Bax, caspase 3, cytochrome C, Beclin, and LC3II mRNA. Finally, this study suggests the potential utility of a cell engineering approach based on the overexpression of the human HSP27 protein for enhancing the production of recombinant viruses and proteins in HEK293 cells.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"5556353"},"PeriodicalIF":2.6,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Diet and Oral Supplementation for the Management of Diabetic Retinopathy and Diabetic Macular Edema: A Narrative Review.","authors":"Angela D'Angelo, Filippo Lixi, Livio Vitiello, Vincenzo Gagliardi, Alfonso Pellegrino, Giuseppe Giannaccare","doi":"10.1155/bmri/6654976","DOIUrl":"10.1155/bmri/6654976","url":null,"abstract":"<p><p>Globally, diabetic retinopathy (DR) and diabetic macular edema (DME) are the leading causes of visual loss in working people. Current treatment approaches mostly target proliferative DR and DME, such as intravitreal injections of antivascular endothelial growth factor agents and laser photocoagulation. Before DR progresses into the more severe, sight-threatening proliferative stage, patients with early stages of the disease must get early and appropriate care. It has been suggested that nutraceuticals, which are natural functional foods with minimal adverse effects, may help diabetic patients with DR and DME. Several in vitro and in vivo studies were carried out over the last years, showing the potential benefits of several nutraceuticals in DR due to their neuroprotective, vasoprotective, anti-inflammatory, and antioxidant properties. Although most of the research is restricted to animal models and many nutraceuticals have low bioavailability, these compounds may adjuvate and implement conventional DR therapies. The purpose of this review is (i) to summarize the complex pathophysiology underlying DR and DME and (ii) to examine the main natural-derived molecules and dietary habits that can assist conventional therapies for the clinical management of DR and DME.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"6654976"},"PeriodicalIF":2.6,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Allelic and Phenotypic Frequencies of the ABO and Rh Blood Types in Pregnant Women in Addis Ababa, Ethiopia.","authors":"Mekdes Wondiye Tedbabe, Dagim Jirata Birri, Takele Taye Desta","doi":"10.1155/bmri/8649988","DOIUrl":"10.1155/bmri/8649988","url":null,"abstract":"<p><p><b>Background:</b> ABO-rhesus (Rh) blood testing screens blood types according to the antigenic properties of red blood cells. <b>Objective:</b> This study reports the allelic and phenotypic frequency distribution of the ABO and Rh blood groups in pregnant women who attended antenatal care (ANC) at Zewditu Memorial Hospital in Addis Ababa, Ethiopia, and the likelihood for the occurrence of erythroblastosis fetalis (E. fetalis). <b>Methods:</b> A retrospective study was conducted on pregnant women who attended ANC from 2015 to 2019 and typed for ABO and Rh blood groups. The Hardy-Weinberg equilibrium was used to determine the allelic frequency of ABO and Rh blood types. The likelihood of the occurrence of E. fetalis was computed. <b>Results:</b> Among the 2453 women who had been admitted to ANC, 2407 (98.1%) pregnant women who had been typed for the ABO and Rh blood groups were included in this retrospective study. We found that Type O blood was the most common one (38.9%), while Types A (31.3%), B (23.8%), and AB (6.0%) blood were scored with modest to lower proportions. Among blood group-typed women, 94.2% were Rh-positive. The allelic frequency of O was 0.62, whereas A (0.22) and B (0.16) had modest proportions. The allelic frequency of D was 0.76 and d was 0.24. The likelihood of the occurrence of E. fetalis was 5%. Our findings show that both the ABO (<i>χ</i>-<i>squared</i> = 6.1439, <i>df</i> = 3, <i>p</i> <i>value</i> = 0.1048) and the Rh (<i>χ</i>-<i>squared</i> = 0.000103, <i>df</i> = 1, <i>p</i> <i>value</i> = 0.9919) blood groups were segregated at the Hardy-Weinberg proportions. Studies need to investigate the evolutionary forces that have made the ABO and Rh blood types segregate at the Hardy-Weinberg proportion.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"8649988"},"PeriodicalIF":2.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitude, and Practice on Antibiotic Use and Resistance Among Undergraduates, Pokhara Metropolitan, Nepal.","authors":"Grinsun Sharma, Shishir Paudel, Anisha Chalise, Biswash Sapkota, Nirmal Raj Marasine","doi":"10.1155/bmri/9928264","DOIUrl":"10.1155/bmri/9928264","url":null,"abstract":"<p><p><b>Background:</b> Antimicrobial resistance (AMR) is a global health problem contributing to increasing rates of morbidity and mortality throughout the world. Inadequate knowledge and misconceptions surrounding antibiotics and their overuse can significantly contribute to the growth and spread of AMR. This study aimed to assess knowledge, attitudes, and practices (KAP) regarding antibiotic use and resistance among undergraduates in Pokhara, Nepal, and examine associations of knowledge and attitudes with demographic factors and specific antibiotic use practices. <b>Methods:</b> A cross-sectional survey was conducted from April to September 2023 among 461 undergraduate students in Pokhara Metropolitan City. Frequency distributions were used to describe participants' KAP regarding antibiotics. Chi-square tests were applied to identify factors significantly associated with knowledge and attitudes toward antibiotics, with a significance level of 5%. <b>Result:</b> Among the total participants, 155 (33.6%, 95% CI: 29.6-38.3) had a lower level of knowledge regarding antibiotics, while a moderate and higher level of knowledge was observed among 208 (45.1%, 95% CI: 40.1-49.5) and 98 (21.3%, 95% CI: 17.5-24.7) students, respectively. Nearly half (53.6%, 95% CI: 48.9-58.2; 50.1%, 95% CI: 45.8-54.4) of the students illustrated positive attitudes and good practices. Factors such as gender, academic discipline, and previous education on antibiotics were associated with students' knowledge regarding antibiotics, at 5% level of significance (<i>p</i> < 0.05). Similarly, a statistically significant relationship existed between students' academic discipline, past courses, and their attitudes toward antibiotics. The knowledge of the participants on the antibiotic use was found to have a statistical relationship with practice-related attributes such as finishing the antibiotic course even after feeling well, giving less preference to antibiotic for cold (<i>p</i> < 0.05). The attitude of the participants toward antibiotics was found to have a statistical relation with practices such as consulting a doctor for antibiotics and finishing the course of antibiotic (<i>p</i> < 0.05). <b>Conclusion:</b>A large proportion of undergraduates have moderate to high knowledge regarding antibiotic use, while only half had a positive attitude and good practice toward antibiotic use, suggesting a large gap existing in awareness of antibiotic resistance and rational use.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"9928264"},"PeriodicalIF":2.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking Dreams and Dreamless Sleep: Machine Learning Classification With Optimal EEG Channels.","authors":"Luis Alfredo Moctezuma, Marta Molinas, Takashi Abe","doi":"10.1155/bmri/3585125","DOIUrl":"10.1155/bmri/3585125","url":null,"abstract":"<p><p>Research suggests that dreams play a role in the regulation of emotional processing and memory consolidation; electroencephalography (EEG) is useful for studying them, but manual annotation is time-consuming and prone to bias. This study was aimed at developing an EEG-based machine learning (ML) model to automatically identify dream and dreamless states in sleep. We extracted features from EEG data using common spatial patterns (CSPs) and the discrete wavelet transform (DWT) and used them to classify EEG signals into dream and dreamless states using ML models. To determine the most informative channels for classification, we used the permutation-based channel selection method and the nondominated sorting genetic algorithm II (NSGA-II). We evaluated our proposal using a public dataset that is part of the DREAM project, which was collected from 58 EEG channels during rapid eye movement (REM) and non-REM sleep, while 28 subjects reported dream or dreamless experiences. We achieved accuracies greater than 0.85 to distinguish dream and dreamless states using CSP-based feature extraction combined with <i>k</i>-nearest neighbors (KNN), as well as through multiple combinations of EEG channels identified by channel selection methods. Our findings suggest that as few as 8-10 EEG channels may be sufficient for dream recognition. Excluding one subject at a time during model training revealed challenges in generalizing the models to unseen subjects. Channel selection methods have proven to be effective in selecting relevant subsets of EEG channels to classify dreams and dreamless experiences. Our results demonstrate the feasibility of automatic dream detection and highlight the need to improve ML generalization.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"3585125"},"PeriodicalIF":2.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence of Typhoid Fever and Its Associated Risk Factors Among Clinically Diagnosed Febrile Patients Visiting the Outpatient Department at Debark Hospital and Drug Susceptibility Patterns of Isolates.","authors":"Atsede Muleta, Naod Meseret","doi":"10.1155/bmri/1717780","DOIUrl":"10.1155/bmri/1717780","url":null,"abstract":"<p><p>Typhoid fever is caused by the bacterium <i>Salmonella</i> Typhi, which poses major health problems in developing countries, including Ethiopia. However, there is limited information regarding typhoid fever, contributing factors with it, and its drug susceptibility pattern in the research area. The aim of this study was to determine the seroprevalence of typhoid fever and its associated risk factors among clinically diagnosed febrile patients at Debark Hospital and evaluate the drug susceptibility patterns of the isolates. A hospital-based cross-sectional study was conducted among 158 febrile patients from December 2022 to April 2023. Blood and stool samples were collected from each febrile patient. The Widal test was used to test <i>Salmonella</i> Typhi O and H antigens sera from blood, and bacteria were cultured from the stool. Gram staining and biochemical analyses were carried out for each isolate. Antibiotic susceptibility testing was performed for the isolates using Kirby-Bauer disk diffusion techniques. Descriptive statistics and logistic regression were used for analysis. In this study, the seroprevalence of typhoid fever among febrile patients at Debark Hospital was 22.8%. Gender (adjusted odds ratio (AOR): 95% confidence interval (CI): 0.02, 0.31, <i>p</i> ≤ 0.001), marital status (AOR: 95% CI: 2.63, 4.66, <i>p</i> ≤ 0.001), family size (AOR: 95% CI: 0.01, 0.31, <i>p</i> ≤ 0.001), residence (AOR: 95% CI: 0.09, 0.83, <i>p</i> = 0.021), practice of using toilet (AOR: 95% CI: 0.08, 0.086, <i>p</i> = 0.027), washing fruits and vegetables before eating (AOR: 95% CI: 0.12, 0.87, <i>p</i> = 0.025), and awareness of typhoid fever transmission and prevention (AOR: 95% CI: 0.12, 0.91, <i>p</i> = 0.032) are the associated risk factors for typhoid fever. Fifty percent of the isolates showed multidrug resistance to two or more antibiotics. It was suggested that improving personal hygiene, providing safe drinking water, and careful use of antibiotics could considerably reduce the prevalence of typhoid fever in the study area.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"1717780"},"PeriodicalIF":2.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11824479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing Solid Waste Management Practices and Challenges in Awi Administrative Zone, Northwestern Ethiopia.","authors":"Belsti Atnkut, Atalaye Nigussie, Bulti Kumera, Alemu Tsega, Fekadu Tiruneh, Wondwosson Kibrie Minale, Fentanesh Anemut, Ewunetu Tazebew, Baye Terefe, Amare Fassil, Getaneh Gebeyehu, Tess Astatkie","doi":"10.1155/bmri/1311674","DOIUrl":"10.1155/bmri/1311674","url":null,"abstract":"<p><p><b>Background:</b> Effective management of solid waste, generated as a result of human activities, is crucial. However, improper solid waste management seriously threatens the environment and public health in developing countries including Ethiopia. <b>Objective:</b> This study is aimed at assessing the status of solid waste management practices and identifying key factors in Awi Administrative Zone, Ethiopia. <b>Methods:</b> A community-based cross-sectional study design was used to collect the data and then analyze using descriptive statistics and logistic regression modeling. The survey was conducted in select kebeles (wards) (administrative subdivisions) of Injibara, Dangila, and Chagni towns, using two-stage sampling techniques. Primary and secondary data sources were utilized. The per capita waste generation rate was calculated based on the total solid waste generated in kilograms per total family size of households per year. <b>Results:</b> The per capita per day solid waste generation rates for Injibara, Dangila, and Chagni were 0.443, 0.456, and 0.487 kg/capita/day, respectively. The composition of household solid waste mainly consisted of biodegradable and nonbiodegradable materials. It was concluded that a significant proportion of household solid waste comprised biodegradable organic matter, which could be efficiently recycled or decomposed through microbial activity. Of the households, 40.6% had access to door-to-door solid waste collection service, and 35.9% and 26.2% of the households disposed their solid waste on riverside bridge/drainage lines and roadside/open land, respectively. The regression analysis showed that the head of the household's age, family size, monthly income, solid waste selling practice, solid waste reduction practice, awareness of solid waste disposal rules, frequency of household cleanup campaign participation, and awareness of the impacts of improper solid waste management on the environment and human health were significantly associated with improper solid waste management practices. <b>Conclusion:</b> The study revealed poor performance in solid waste management in the study area, attributed to factors such as inadequate collection system design and schedule, open burning of refuse, substandard condition of the final dumpsite, and lack of community awareness leading to illegal dumping. <b>Recommendations:</b> Based on the findings of the study, we recommend that the town municipality strengthen its door-to-door solid waste collection service and distribution of communal bin containers, conduct environmental assessments for better dumpsite selection, and implement a community-based waste management system to ensure sustainable solutions and continuous education on proper solid waste management practices.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"1311674"},"PeriodicalIF":2.6,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11824480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}