BioMed Research International最新文献

{"title":"Single-Cell Sequencing Reveals the Immunosuppressive Trajectory in the Tumor Microenvironment of Human Giant Cell Tumor of Bone.","authors":"Yiming Liu, Wei Luo, Yude Xu, Xiguan Yao, Libing Dai, Qiao Feng, Peigeng Wang, Weichao Yang, Yi Feng, Haixiong Miao, Suixiang Huang, Dongping Ye","doi":"10.1155/bmri/9855803","DOIUrl":"10.1155/bmri/9855803","url":null,"abstract":"<p><strong>Background: </strong>Giant cell tumor of bone (GCTB) presents considerable complexity in tumor microenvironment (TME) because of its intricate intercellular heterogeneity and the presence of an immunosuppressive milieu. In order to understand the complex gene expression patterns and cell interactions in GCTB, we carried out a thorough investigation using single-cell RNA sequencing (scRNA-seq).</p><p><strong>Methods: </strong>We examined scRNA-seq data from 7091 cells that were collected after surgical removal of GCTB. Following the initial quality control process, 10 separate groups of cells were distinguished, which consisted of dendritic cells, endothelial cells, macrophage cells, mast cells, monocyte cells, neutrophil cells, tumor cells, osteoclast cells, pericyte cells, and T cells. Additional analysis uncovered distinct categories within tumor-associated macrophages (TAMs), CD8+ T cells, and CD4+ T cells. The differentiation mechanisms of TAMs, CD8+ T cells, and CD4+ T cells were explored using pseudo-time trajectory analysis. The CellPhoneDB study revealed the interactions between various cell types within the TME of GCTB.</p><p><strong>Results: </strong>TAMs have been identified as the main infiltrating cells in GCTB. These TAMs exhibit several subtypes that are characterized by specific marker genes and functional states. The identification of several subgroups within CD8+ T cells that are involved in regulating immunological checkpoints underscores the difficulties encountered when attempting to employ immune checkpoint blockade therapy for GCTB. T cell exhaustion poses a major barrier to the efficacy of antitumor immune responses. Research suggests a strong correlation between TAMs and exhausted T cells (Texs) in the TME. The high number of regulatory T cells (Tregs) highlights the immunosuppressive nature of the immunological environment in GCTB. Significant interactions have been observed between TAMs and tumor cells, highlighting their crucial involvement in immune evasion strategies.</p><p><strong>Conclusion: </strong>This scRNA-seq study provides a general overview of the different cellular compositions and immune interactions within GCTB. The identified subtypes and communication networks provide valuable information about the immunosuppressive environment of GCTB, laying the foundation for prospective therapeutic approaches targeting specific cell types or interactions.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 ","pages":"9855803"},"PeriodicalIF":2.9,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12862500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicinal Plants and Lead Phytomolecules as Immunomodulators: An Updated Review.","authors":"Gurdeep Singh, Vikas Sharma, Blessing Nnenna Udeh","doi":"10.1155/bmri/6998034","DOIUrl":"10.1155/bmri/6998034","url":null,"abstract":"<p><p>All therapeutic interventions aimed at modulating the immune response to pathogens, self-antigens, carcinogens, or xenogeneic antigens are referred to as immunomodulation, which either prevents hyperactivation or restores the appropriate response of the immune system. Since antiquity, medicinal plants have been used as a source of immune-boosting medicines with fewer side effects. These medicinal plants, for example, <i>Curcuma longa</i>, <i>Camellia sinensis</i>, <i>Artemisia annua</i>, and <i>Andrographis paniculata</i>, have been used to treat immune system disorders such as multiple sclerosis, psoriasis, lupus, and organ transplantation. Herein, we review the currently accessible medicinal plants, their phytoconstituents, and underlying mechanisms of immunomodulation.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 ","pages":"6998034"},"PeriodicalIF":2.9,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12864545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Additive Zirconia in Dentistry: Techniques, Trends, and Future Perspectives\".","authors":"","doi":"10.1155/bmri/9893132","DOIUrl":"10.1155/bmri/9893132","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/bmri/6602281.].</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 ","pages":"9893132"},"PeriodicalIF":2.3,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12862988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural Characterization and Functional Annotation of Hypothetical Proteins in the Multidrug-Resistant Strains of <i>Pseudomonas aeruginosa</i>.","authors":"Fatemeh Nasiri Khoonsari, Zahra Zafari","doi":"10.1155/bmri/2974616","DOIUrl":"10.1155/bmri/2974616","url":null,"abstract":"<p><strong>Introduction: </strong><i>Pseudomonas aeruginosa</i> is a leading cause of severe nosocomial infections worldwide. This opportunistic pathogen is associated with increased morbidity and mortality rates due to its high levels of antibiotic resistance. The identification of novel therapeutic targets is therefore a pressing global health priority. This study aims to identify potential drug targets and vaccine candidates through structural characterization and functional annotation of hypothetical proteins (HPs) commonly found in multidrug-resistant <i>Pseudomonas aeruginosa</i> strains.</p><p><strong>Methods: </strong>The multidrug-resistant and carbapenem-resistant strains of <i>Pseudomonas aeruginosa</i> were retrieved from genomic databases and 15 common HPs among these resistant strains, with a minimum length of 200 amino acids, were obtained and bioinformatics tools were employed to predict the structural, functional, and immunological properties of these common HPs.</p><p><strong>Results: </strong>Two common HPs (gene ID: 2877781443 and 2877781545) were identified as the most promising drug and vaccine candidates among the investigated HPs based on their structural and physicochemical properties, functional domains, signals peptides, subcellular localization, pathogenicity factors, toxicity, antigenicity, and allergenicity.</p><p><strong>Conclusion: </strong>The findings of this study will contribute to the development of novel vaccine and drug candidates against <i>Pseudomonas aeruginosa</i> through experimental validations.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 ","pages":"2974616"},"PeriodicalIF":2.9,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12864544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Interleukin-35 Levels in Oral Squamous Cell Carcinoma and Salivary Gland Tumors: Implications for Early Detection and Prognosis.","authors":"Maryam Zahed, Sara Maroofi, Jannan Ghapanchi, Bijan Khademi, Abbas Ghaderi, Mohamad Javad Fattahi, Niloofar Hayati, Fardad Khoubani","doi":"10.1155/bmri/6091357","DOIUrl":"10.1155/bmri/6091357","url":null,"abstract":"<p><strong>Background: </strong>Oral cancer, particularly oral squamous cell carcinoma (OSCC), is a major global health concern, with late-stage diagnoses significantly lowering survival rates. Salivary gland tumors (SGTs), though less common, pose diagnostic challenges due to their varied presentation. This study investigates the role of interleukin-35 (IL-35) in OSCC and SGTs, aimed at assessing its potential as a biomarker for early detection and prognosis.</p><p><strong>Methods: </strong>A cross-sectional study was conducted, including 65 OSCC patients, 65 SGTs patients, and 50 healthy individuals as a control group. Inclusion criteria included age over 18 years, negative HPV confirmation, and histopathologically confirmed cancer diagnosis (SGT or OSCC). Blood samples were collected from all participants. Serum IL-35 levels were measured using the ELISA kit.</p><p><strong>Results: </strong>IL-35 levels varied significantly between the groups (<i>p</i> = 0.002), with the lowest levels detected in the SGT group. Pairwise comparisons revealed that IL-35 levels were significantly lower in the SGTs patients (5.45 ± 6.03 pg/mL) compared to both the OSCC group (9.21 ± 10.81 pg/mL, <i>p</i> = 0.002) and the control group (10.50 ± 11.77 pg/mL, <i>p</i> = 0.004). IL-35 levels were significantly lower in patients with malignant SGTs (5.45 ± 6.03 pg/mL) compared to healthy controls (<i>p</i> = 0.002). There were no significant differences in IL-35 levels between benign and malignant SGTs (<i>p</i> = 0.133). In OSCC patients, IL-35 levels did not significantly differ from those in the control group (<i>p</i> > 0.05). Furthermore, OSCC tumor characteristics, including tumor origin and lymphatic involvement, showed no significant correlation with IL-35 levels (<i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>The study indicates that IL-35 levels are notably reduced in SGTs compared to healthy individuals. However, no significant difference was observed between benign and malignant SGTs. The absence of significant correlation in OSCC patients suggests that IL-35 may have a minor role in this type of cancer, highlighting the potential need for other biomarkers to improve early detection.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 ","pages":"6091357"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12862003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Hypertension Risk Diagnosis Using a Hybrid Machine Learning Framework: Leveraging Body Composition Data.","authors":"Abdul Wahid Mirzaye, Hamid Saadatfar, Mohammad Ali Nematollahi","doi":"10.1155/bmri/6335947","DOIUrl":"10.1155/bmri/6335947","url":null,"abstract":"<p><p>Hypertension, widely recognized as the \"silent killer,\" remains a leading cause of cardiovascular, renal, and neurological complications worldwide. This study proposes a dual-scenario hybrid machine learning framework for hypertension risk prediction using noninvasive body composition features, aimed at enhancing both interpretability and predictive reliability. In Scenario 1, an unsupervised clustering analysis inspired by self-labeling principles was performed exclusively on hypertensive individuals, where five physiological subgroups were identified via K-Means clustering and validated using Silhouette (0.3371), Davies-Bouldin (1.0094), and Calinski-Harabasz (720.10) indices. Significant intercluster variability (<i>p</i> < 0.001) was observed across key indicators such as FATP, RLFATP, LLFATP, FATM, and age. Among the tested models, the support vector machine (SVM) with random oversampling achieved the best performance (accuracy = 99.08<i>%</i>, F1 = 98.04<i>%</i>, AUC = 99.98<i>%</i>), confirming effective subgroup discrimination. In Scenario 2, a comprehensive binary classification between healthy and hypertensive subjects was conducted using five models-ExtraTrees, KNN, SVM, Gaussian Naive Bayes, and Decision Tree-across multiple configurations. The cluster-augmented dataset yielded the best results, with the ExtraTrees classifier achieving superior performance (accuracy = 98.23<i>%</i>, recall = 98.30<i>%</i>, precision = 98.17<i>%</i>, F1 = 98.23<i>%</i>, AUC = 99.87<i>%</i>). Clustering and feature selection both improved generalization, particularly for ensemble-based learners. Overall, Scenario 2 demonstrated the highest predictive accuracy and stability, whereas Scenario 1 provided valuable interpretability through subgroup discovery. These findings highlight that integrating unsupervised clustering with supervised classification offers a robust and explainable framework for personalized hypertension risk prediction, contributing to early detection and precision healthcare.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 ","pages":"6335947"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12862000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rational Design of Novel Inhibitors: Integrating 3D-QSAR and Molecular Dynamics.","authors":"Neda Shakour, Aida Fayyaz, Farzin Hadizadeh, Saghi Sepehri","doi":"10.1155/bmri/4138899","DOIUrl":"10.1155/bmri/4138899","url":null,"abstract":"<p><p>This study presents an integrated computational framework that combines three-dimensional quantitative structure-activity relationship (3D-QSAR) modeling with molecular dynamics (MD) simulations to advance the rational design of triazole-based urease inhibitors. Given the role of urease as a central virulence factor in <i>Helicobacter pylori</i> and its increasing relevance in antibiotic-resistant infections, effective predictive methodologies are essential for early-stage inhibitor development. A dataset of 54 triazole derivatives was examined using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA), generating statistically robust and predictive models that elucidate the steric, hydrophobic, and hydrogen-bonding features underlying inhibitory potency. These insights, supported by molecular docking and structure-activity relationship analyses, informed the construction of a pharmacophore model used to screen the ZINC database. Several candidate molecules, including ZINC84668437, ZINC84669798, and ZINC244633273, emerged as computationally promising and demonstrated favorable predicted druglikeness and ADMET characteristics. MD simulations were subsequently employed to evaluate the dynamic stability and conformational behavior of the ligand-urease complexes, reinforcing the coherence of the integrated computational workflow. The primary contribution of this work resides in its methodological integration of complementary in silico approaches rather than in experimental validation. Although the findings offer mechanistic insights and prioritize potential lead compounds, they remain predictive and necessitate future empirical confirmation. Overall, the study establishes a rigorous and academically grounded computational strategy that can guide subsequent efforts in the design of selective urease inhibitors for <i>H. pylori</i>-associated diseases.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 ","pages":"4138899"},"PeriodicalIF":2.9,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12860141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146103762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Detection and Prediction of Neurodegenerative Disorders by Long Noncoding RNA Signature Analysis among Bangladeshi Population\".","authors":"","doi":"10.1155/bmri/9764056","DOIUrl":"10.1155/bmri/9764056","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/2023/9416281.].</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 ","pages":"9764056"},"PeriodicalIF":2.9,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12860136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146103656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of miRNA Expression in Pediatric Cirrhosis Caused by BA and PFIC.","authors":"Fatemeh Khosravi, Ramin Yaghobi, Afsoon Afshari, Nasrin Motazedian, Bita Geramizadeh, Tayebeh Kazemi, Seyed Mohsen Dehghani","doi":"10.1155/bmri/4087823","DOIUrl":"10.1155/bmri/4087823","url":null,"abstract":"<p><p>Liver cirrhosis is one of the most common causes of death for pediatric patients with cholestasis. Because microRNA (miRNA) plays a part in the pathogenesis of the disease, comparing the changes in miRNA expression in cholestatic patients with liver cirrhosis could be helpful for therapeutic or prognostic purposes. miRNA levels in cirrhotic pediatric patients with progressive familial intrahepatic cholestasis (PFIC) and biliary atresia (BA) were studied in this research to comprehend the molecular distinctions and the significance of miRNA regulation in fibrosis and liver cirrhosis. Blood samples were collected from 43 PFIC patients and 84 BA patients, all of whom were confirmed to have liver cirrhosis. The in-house SYBR Green RT-qPCR techniques were established to assess the variations in the expressions of 12 miRNAs. Utilizing bioinformatics tools, the gene targets of the studied miRNAs were examined. Patients' expression of 12 miRNAs was higher than that of the healthy group. However, there was a notable distinction between the miRNAs in PFIC and BA. The levels of miR-34, miR-155, miR-199, miR-200b, and miR-222 were significantly higher in BA than in PFIC. PFIC showed a significantly higher level of miR-223 than BA. The predictive importance of distinct miRNAs in both diseases was revealed by the AUC values. In BA, miR-222 was associated with both liver transplantation and the PELD score. Death was correlated with miR-21, miR-155, miR-199, and miR-200 in BA and miR-34 in PFIC. The analysis showed the significance of the connection between miRNA expression and PI3K/Akt and TGF-<i>β</i> signaling in pediatric liver cirrhosis. Future investigations can evaluate the significance of the studied miRNAs as novel therapeutic targets and diagnostic options.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 ","pages":"4087823"},"PeriodicalIF":2.9,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12860219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146103643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Hepatoprotective Efficacy of Bee Pollen and Bee Pollen Ethanolic Extract-Loaded Solid Lipid Nanoparticles Against Lead Acetate-Induced Hepatotoxicity in Male Wistar Rats.","authors":"Khashayar Sanemar, Reza Mahjub, Fatemeh Nouri, Mojdeh Mohammadi","doi":"10.1155/bmri/3824359","DOIUrl":"10.1155/bmri/3824359","url":null,"abstract":"<p><strong>Introduction: </strong>Bee pollen, a natural product rich in polyphenols, exhibits remarkable antioxidant, anti-inflammatory, and hepatoprotective properties.</p><p><strong>Aim: </strong>This study was aimed at evaluating the hepatoprotective effects of solid lipid nanoparticles (SLNs) loaded with bee pollen.</p><p><strong>Materials and methods: </strong>SLNs were formulated and optimized by varying surfactant ratios and lipid contents at two different temperatures.</p><p><strong>Results and discussion: </strong>The optimized bee pollen SLNs demonstrated a particle size of 118.6 nm, a PdI of 0.35, a zeta potential of -22.6 mV, and an entrapment efficiency of 92.7%. The in vitro release study showed minimal release during the initial 120 min, followed by a continuous increase up to 48 h, indicating a sustained and prolonged release profile. Both bee pollen and bee pollen ethanolic extract-loaded SLNs exhibited significant cytoprotective effects against lead-induced cytotoxicity in HepG2 cells. In vivo studies revealed that treatment with bee pollen and especially bee pollen SLNs substantially ameliorated lead-induced hepatic injury. Treatment notably reduced serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, malondialdehyde, and nitric oxide. Additionally, it enhanced the activity of glutathione peroxidase, catalase, superoxide dismutase, and total antioxidant capacity, as well as levels of total thiol, reduced glutathione, and liver tissue proteins. Histopathological analysis further confirmed that treatment, particularly with bee pollen SLNs, significantly improved lead-induced hepatic structural damage.</p><p><strong>Conclusion: </strong>These findings confirm that bee pollen, and more prominently its SLN formulation, possesses strong hepatoprotective potential.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 ","pages":"3824359"},"PeriodicalIF":2.9,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12856774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146103690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}