BioMed Research International最新文献

{"title":"The Dilemma and Wisdom in Translating <i>p</i> Values: A Collaborative Approach to Strengthening Scientific Validity.","authors":"Mohamad Adam Bujang","doi":"10.1155/bmri/6703756","DOIUrl":"https://doi.org/10.1155/bmri/6703756","url":null,"abstract":"<p><p>The <i>p</i> value remains a widely used statistical tool for assessing the significance of research findings, yet its interpretation and application often provoke debate. While the <i>p</i> value provides a measure of evidence against the null hypothesis, it does not convey essential information about the strength of an effect or its statistical precision. Therefore, this paper critically examines the dilemma of translating <i>p</i> values into meaningful scientific inferences. Using illustrative examples, we demonstrate how the misapplication of <i>p</i> values can misguide policy, clinical practice, and scientific discourse. To address these challenges, this article proposes a collaborative approach involving researchers, journal reviewers, and the scholarly audience. This includes a comprehensive checklist to promote clear documentation, critical evaluation, and a more nuanced interpretation of statistical evidence. By fostering a nuanced understanding of statistical evidence, this initiative seeks to advance scientific validity and ensure that research findings contribute meaningfully to societal progress.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"6703756"},"PeriodicalIF":2.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11976038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of DNA Methylation in the Pathogenesis of Skin Disorders: Mechanisms, Inhibitors of Methylation-Related Enzyme, and Molecular Docking Studies.","authors":"Anchal Rani, Gagandeep Kaur, Ravinder Kumar, Rohan Samir Kumar Sachan, Mukesh Kumar, Harsh Sable, Abdel Rahman Mohammad Al Tawaha, Shahid Malik, Arun Karnwal, Tabarak Malik","doi":"10.1155/bmri/7002918","DOIUrl":"10.1155/bmri/7002918","url":null,"abstract":"<p><p>DNA methylation is an epigenetic mechanism modulating gene expression without altering the genetic sequence and plays a significant role in skin disorders. Methylation patterns on specific genes can lead to either overexpression or suppression, impacting cellular functions critical to skin health. Skin disorders such as atopic dermatitis, eczema, androgenetic alopecia, systemic lupus erythematosus, psoriasis, and systemic sclerosis have been linked to abnormal DNA methylation, which contributes to disease progression through immune dysregulation, barrier dysfunction, and inflammation. The methylation of genes like S100A2 and FCERIG in atopic dermatitis or FLG in eczema illustrates how modifications affect immune pathways and skin integrity. Recent advancements in DNA methylation analysis have enhanced the precision of detecting methylation levels and their influence on gene expression, leading to a deeper understanding of disease mechanisms. Identifying aberrant methylation patterns offers potential biomarkers for early diagnosis and therapeutic targets, especially in autoimmune and inflammatory skin diseases. Further exploration of epigenetic changes could pave the way for innovative treatments, addressing underlying epigenetic disruptions that characterize these conditions.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"7002918"},"PeriodicalIF":2.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythroferrone-Driven Regulation of Hepcidin and Iron Levels in Polytransfused Sickle Cell Anaemia Patients: A Prospective Study.","authors":"Samuel Kwasi Appiah, Charles Nkansah, Godfred Amoah Appiah, Gabriel Abbam, Felix Osei-Boakye, Samira Daud, Kofi Mensah, Safo Adwoa, Korah Seedolf Kuwaahsuore, Emmanuel Yeboah, Abu Siraj Salma Tiyumba, Dennis Thompson, Viel Mary Paula, Louis Adda Duibajia, Peter Takyia, Franklina Ataa Kwarteng, Obed Odame Asiedu, Firdaus Ibrahim Sukasorr, Vincent Kawuribi, Boniface Nwofoke Ukwah, Ejike Felix Chukwurah","doi":"10.1155/bmri/6803051","DOIUrl":"10.1155/bmri/6803051","url":null,"abstract":"<p><p>The interplay of erythroferrone (ERFE), hepcidin, and ferroportin is crucial for ensuring systemic iron homeostasis. This study determined the influence of ERFE on hepcidin and iron levels in polytransfused patients with sickle cell anaemia (SCA). This multicentre case-control study recruited 60 SCA participants and 30 controls (HbA), aged 2-34 years, from Tamale Teaching Hospital; Methodist Hospital, Wenchi; and Seventh Day Adventist Hospital, Sunyani, Ghana, between the periods of March to July 2023. About 4 mL of blood was collected for a full blood count using a haematology analyzer and serum ERFE, hepcidin, ferroportin, and ferritin estimation using an enzyme-linked immunosorbent assay. Data were analyzed using SPSS Version 26.0. ERFE (<i>p</i> < 0.001), ferroportin (<i>p</i> = 0.016), ferritin (<i>p</i> < 0.001), serum iron (<i>p</i> < 0.001), transferrin (<i>p</i> = 0.001), soluble transferrin receptor (sTFR) (<i>p</i> = 0.019), TWBC (<i>p</i> < 0.001), and platelet (<i>p</i> < 0.001) were significantly higher in SCA participants and hydroxyurea-naïve participants than in the control group and hydroxyurea-treated participants, respectively. Levels of hepcidin (<i>p</i> < 0.001), red blood cell (<i>p</i> < 0.001), haemoglobin (<i>p</i> < 0.001), and haematocrit (<i>p</i> < 0.001) were lower in the SCA and hydroxyurea-naïve groups than in the control and hydroxyurea-treated groups, respectively. An inverse correlation was observed between serum ERFE and hepcidin (<i>r</i> = -0.391, <i>p</i> = 0.002) and hepcidin and ferroportin (<i>r</i> = -0.266, <i>p</i> = 0.040), while ferritin (<i>r</i> = 0.439, <i>p</i> < 0.001) and ferroportin (<i>r</i> = 0.309, <i>p</i> = 0.016) showed a positive correlation with ERFE. No correlation was found between serum hepcidin and ferritin levels (<i>r</i> = 0.025, <i>p</i> = 0.853). Again, participants with regular blood transfusions had significantly higher levels of ERFE (<i>p</i> < 0.001) and ferritin (<i>p</i> = 0.002) than those with rare and no transfusions per year. None of the SCA participants had done iron testing. In conclusion, the negative impact of ERFE on hepcidin levels may exacerbate the risk of iron burden, as evident by elevated iron levels in SCA patients and the need for regular monitoring of the iron status of polytransfused SCA patients.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"6803051"},"PeriodicalIF":2.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11964725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the Gap in Smoking Cessation: Unveiling Tobacco Harm Reduction in Pakistan Through Print Media Content Analysis.","authors":"Abdul Hameed, Daud Malik","doi":"10.1155/bmri/3822509","DOIUrl":"10.1155/bmri/3822509","url":null,"abstract":"<p><p>This paper provides an in-depth content analysis of safer smoking alternatives in Pakistani print media during a 5-year period (2018-2022). The mainstream print media in the English and Urdu languages is grappling with understanding the importance of tobacco harm reduction and, as a result, the safer nicotine alternatives as one of the options to address combustible smoking. Largely, the perception portrayed by the English and Urdu newspapers through news stories, articles, and so on regarding tobacco harm reduction and safer nicotine alternatives is negative. This may be due to the strong opposition to safer nicotine alternatives by the organizations working on tobacco control in Pakistan. However, on the other hand, there has been positive coverage of safer nicotine products, with the main message around how they can help adult smokers reduce harm to their health and ultimately quit smoking. Clearly, the print media need more awareness and education regarding tobacco harm reduction and safer nicotine alternatives. The emphasis should be on providing evidence-based information about safer nicotine alternatives and their role in addressing the issue of combustible smoking prevalence.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"3822509"},"PeriodicalIF":2.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11964702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Height Growth Modeling in Ethiopian Children and Adolescents Aged 7-20 Years: A Prospective Cohort Study.","authors":"Dereje Danbe Debeko, Ayele Taye Goshu","doi":"10.1155/bmri/7288345","DOIUrl":"10.1155/bmri/7288345","url":null,"abstract":"<p><p><b>Background:</b> Modeling physical growth plays a vital role in examining and defining growth trajectories related to public health and well-being. <b>Aim:</b> The primary objective of this study was to model height growth in Ethiopian children and adolescents aged 7-20 years to estimate the growth variations across the Ethiopian regions. <b>Methods:</b> A total of 891 children and adolescents aged 7.5-20 years were included in the study. To estimate growth spurts within and between study subjects over time, the SITAR and PB1 models were fitted to the height growth measurements gathered in four survey rounds to. <b>Results:</b> Boys experienced puberty 2.6 years later than girls did, while the mean peak height velocity was estimated to be 5.5 cm/year in boys and 6.3 cm/year in girls. The mean adult height in boys was estimated to be 174.6 cm, while in girls, it was estimated to be 162.2 cm. Both girls (<i>p</i> < 0.005) and boys (<i>p</i> < 0.008) in Amhara and Tigrai regions were significantly shorter compared to their counterparts in Addis Ababa. However, there was no significant height difference between girls and boys in former SNNPRS region, Oromia region, and Addis Ababa. Height at peak velocity strongly correlated with the rate of change during the pubertal period. The rate of change in both boys and girls during the prepubertal and pubertal growth stages was inversely correlated with the adult height. <b>Conclusions:</b> Children who had rapid rate of change during the prepubertal and pubertal periods attained adulthood later in life. There was a significantly different height growth in children and adolescents across the regions of Ethiopia.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"7288345"},"PeriodicalIF":2.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical Analysis of Ankle Stability Following Deltoid Ligament Repair and Reconstruction.","authors":"Ali Ahmadi Pirshahid, Pawel Brzozowski, Olawale Sogbein, Radovan Zdero, Aaron Gee, Mansur Halai, Emil Schemitsch, David W Sanders, Abdel Rahman Lawendy, Christopher Del Balso","doi":"10.1155/bmri/6313005","DOIUrl":"10.1155/bmri/6313005","url":null,"abstract":"<p><p><b>Background:</b> The deltoid ligament has been shown to contribute to the stability of the ankle mortise, preventing valgus talar tilt, external rotation (ER), and translation. Research to date assessing the appropriateness of deltoid repair to reintroduce medial stability to a fractured ankle is unclear. Deltoid ligament reconstruction using autograft or allograft has been proposed in cases of chronic deltoid insufficiency. This biomechanical study sought to assess the stability offered by deltoid repair and reconstruction compared to the native deltoid ligament in its intact and defunctioned states. <b>Materials and Methods:</b> Twelve (six pairs) fresh frozen cadaveric lower extremities with intact deltoid ligaments underwent biomechanical assessment in a custom-made multiaxial testing apparatus. Each specimen was tested in plantarflexion/dorsiflexion (PF/DF), inversion/eversion (IV/EV), and internal rotation (IR)/ER and analyzed for angular range of motion (ROM) and stiffness. The specimens were tested with an intact deltoid ligament and following disruption via transection. Subsequently, paired specimens were randomized to either deltoid repair or reconstruction. A single double-loaded suture anchor was used to repair the deep and superficial deltoid ligaments. The tibialis anterior tendon was used as an autograft in the reconstruction group. <b>Results:</b> Normalized ROM and stiffness were significantly different in deficient specimens compared to all other groups during PF/DF. During IR/ER, the deficient ankle was significantly different from the intact and repair state. For IV/EV, deficient specimen ROM was significantly greater than the intact or repair states, while the stiffness for the deficient ankles was significantly less. <b>Conclusion:</b> Deltoid repair and reconstruction were comparable in returning the ankles to an intact state and conferring stability. These results suggest that in cases with insufficient or unstable deltoid ligament where repair is not possible, reconstruction has the potential to be a reliable alternative, but further studies are warranted to understand all advantages/disadvantages.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"6313005"},"PeriodicalIF":2.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peroxide-Free Titanium Dioxide Nanoparticle-Based Photocatalytic Bleaching: In Vitro Study on Bovine Teeth.","authors":"Tainah Oliveira Rifane, Isabel Silva Nascimento, Suely Cristina Aragão Veras Santos, Lucca Reis Mesquita, Diego Martins de Paula, Victor P Feitosa","doi":"10.1155/bmri/9311501","DOIUrl":"10.1155/bmri/9311501","url":null,"abstract":"<p><p><b>Objective:</b> This study is aimed at assessing the bleaching efficacy of titanium dioxide (TiO2) nanoparticle suspensions at different concentrations and exposure times for photocatalysis and evaluating their potential as a peroxide-free alternative to carbamide peroxide in dental bleaching. <b>Materials and Methods:</b> Sixty bovine incisors were stained with black tea and treated with different bleaching protocols: (1) control (16% carbamide peroxide), (2) TiO₂-50 wt% for 10 min (TiO₂ 50/10), (3) TiO₂-50 wt% for 50 min (TiO₂ 50/50), (4) TiO₂-10 wt% for 50 min (TiO2 10/50), and (5) TiO₂-10 wt% for 10 min (TiO₂ 10/10). The agents were exposed to UV light (395 nm) for photocatalysis before application. All treatments were applied daily for 2 h over 21 days. Color change (Δ<i>E</i>00) was measured using a digital spectrophotometer (VITA Easyshade V), and pH was assessed using pH strips. <b>Results:</b> The data were analyzed using one-way ANOVA and Tukey's test. TiO₂ 50/50 showed significantly superior bleaching effects compared to all other groups (<i>p</i> < 0.001). TiO₂ 10/50 and TiO₂ 10/10 demonstrated intermediate bleaching results, with no significant difference between them (<i>p</i> = 0.0875). The control and TiO₂ 50/10 groups exhibited the lowest color variation (<i>p</i> = 0.102). All groups maintained a pH of 6 before and after 2 h of the at-home bleaching protocol. <b>Conclusion:</b> TiO₂ nanoparticle suspensions may be a viable peroxide-free alternative for dental bleaching, particularly at higher concentrations and longer photocatalysis exposure times.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"9311501"},"PeriodicalIF":2.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11964721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Access to ART Services: Lived Experiences and Coping Strategies of HIV-Positive Persons With Visual Impairment in Lira District, Northern Uganda.","authors":"Gloria Ketty Acila, Noeline Aju Ijorea, Amir Kabunga, Mercy Joy Angom, Sandra Talemwa, Patrick Ayer, Anna Grace Auma","doi":"10.1155/bmri/1903886","DOIUrl":"10.1155/bmri/1903886","url":null,"abstract":"<p><p><b>Background:</b> Despite progress in the HIV/AIDS response, marginalized populations persistently face unique challenges in accessing essential healthcare services, including antiretroviral therapy. The aim of this qualitative study is to explore and understand the lived experiences of individuals living with HIV and visual impairment in Lira District, Northern Uganda, specifically focusing on their access to antiretroviral therapy services. Additionally, the study is aimed at identifying and analyzing the coping strategies employed by this population in navigating the intersectionality of HIV and visual impairment. <b>Methods:</b> This qualitative study, conducted in Lira District, Northern Uganda, employed a descriptive phenomenological design. Thirty in-depth interviews were conducted at Lira Regional Referral Hospital, focusing on individuals living with both HIV and visual impairment. Data collection involved a semistructured interview guide, addressing key issues derived from a literature review. Thematic analysis was used for data analysis, guided by Braun and Clarke's framework. <b>Results:</b> Participants (<i>N</i> = 30) exhibited diverse sociodemographic characteristics, with ages ranging from 19 to 68 years. A number of themes emerged during data analysis: individuals developing visual impairment before and after ART initiation. Emotional challenges, strained relationships, and perceived burdenship were common themes among participants. Limited understanding of the cause of sight loss and a heightened perceived risk of HIV infection were evident. Challenges in accessing ART services included transportation difficulties, negative attitudes from healthcare workers, and a lack of trust in community drug distribution points. Participants employed various coping strategies, including prayers/religion, reliance on social support networks, denial, acceptance, and community rehabilitation. Positive religious beliefs offered hope, while social support played a crucial role in adaptation. Community rehabilitation and support were highlighted as instrumental in aiding coping. <b>Conclusion:</b> Despite awareness about the risk of HIV infection, significant barriers persist in accessing ART services for persons with visual impairment. Coping strategies underscore the importance of addressing psychosocial aspects. Tailored interventions, education, and policy changes are imperative to enhance inclusivity and accessibility of healthcare services for this vulnerable population in Uganda.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"1903886"},"PeriodicalIF":2.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11944839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of UCOE and HSP27 Molecular Elements to Improve the Stable Protein Production on HEK293 Cells.","authors":"Concepción Sosa-García, Uriel Abdallah Sánchez-Pacheco, Carlos Alberto Tavira-Montalvan, Angélica Meneses-Acosta","doi":"10.1155/bmri/5556353","DOIUrl":"10.1155/bmri/5556353","url":null,"abstract":"<p><p>Recombinant proteins represent one of the greatest achievements of modern pharmaceutical biotechnology, as they are increasingly used across nearly all branches of medicine to treat a wide range of conditions. In response to this demand, various cell engineering approaches have been developed to improve their expression. Some of these approaches involve the use of genetic elements that prevent the silencing of the gene of interest, as well as the generation of resistant cell lines to inhibit or avoid programmed cell death (PCD). This research focuses on analyzing the effects of overexpression of UCOE elements and the HSP27 protein, both individually and together, on the production of human rIFN<i>γ</i> in HEK293 cells. Our results show that 4-Kb UCOE elements have no effect on protein production in HEK293 cells, while overexpression of HSP27 prolongs the stationary phase during growth kinetics. The Qp of rIFN<i>γ</i> is 96-fold higher in clones containing the HSP27/UCOE combination compared to the clone containing only UCOE elements or to the control HEK293 cells. These results correlate with the MCP analyses, which showed that overexpression of HSP27 decreased the expression of Bax, caspase 3, cytochrome C, Beclin, and LC3II mRNA. Finally, this study suggests the potential utility of a cell engineering approach based on the overexpression of the human HSP27 protein for enhancing the production of recombinant viruses and proteins in HEK293 cells.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"5556353"},"PeriodicalIF":2.6,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Diet and Oral Supplementation for the Management of Diabetic Retinopathy and Diabetic Macular Edema: A Narrative Review.","authors":"Angela D'Angelo, Filippo Lixi, Livio Vitiello, Vincenzo Gagliardi, Alfonso Pellegrino, Giuseppe Giannaccare","doi":"10.1155/bmri/6654976","DOIUrl":"10.1155/bmri/6654976","url":null,"abstract":"<p><p>Globally, diabetic retinopathy (DR) and diabetic macular edema (DME) are the leading causes of visual loss in working people. Current treatment approaches mostly target proliferative DR and DME, such as intravitreal injections of antivascular endothelial growth factor agents and laser photocoagulation. Before DR progresses into the more severe, sight-threatening proliferative stage, patients with early stages of the disease must get early and appropriate care. It has been suggested that nutraceuticals, which are natural functional foods with minimal adverse effects, may help diabetic patients with DR and DME. Several in vitro and in vivo studies were carried out over the last years, showing the potential benefits of several nutraceuticals in DR due to their neuroprotective, vasoprotective, anti-inflammatory, and antioxidant properties. Although most of the research is restricted to animal models and many nutraceuticals have low bioavailability, these compounds may adjuvate and implement conventional DR therapies. The purpose of this review is (i) to summarize the complex pathophysiology underlying DR and DME and (ii) to examine the main natural-derived molecules and dietary habits that can assist conventional therapies for the clinical management of DR and DME.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"6654976"},"PeriodicalIF":2.6,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}