BioMed Research International最新文献

{"title":"Seroprevalence of Hepatitis B and C and HIV Infections and Associated Risk Factors Among Pregnant Women Attending Antenatal Care Unit at Simada Hospital, South Gondar Zone, Northwest Ethiopia.","authors":"Solomon Tesfaye, Tirngo Abebaw, Endalkachew Bizualem, Daniel Mehabie, Amir Alelign","doi":"10.1155/bmri/6895237","DOIUrl":"https://doi.org/10.1155/bmri/6895237","url":null,"abstract":"<p><p>Hepatitis and human immunodeficiency virus (HIV) are major public health issues in developing countries, including Ethiopia. These viruses can be transmitted from mother to child during birth or through contact with contaminated blood. In many areas of Ethiopia, viral hepatitis and HIV infections are significant health concerns for pregnant women. However, there is limited information about these issues in various parts of the country, particularly in the Amhara Region. Therefore, this study was aimed at determining the prevalence of Hepatitis B virus (HBV), Hepatitis C virus (HCV), and HIV infections and identifies the associated risk factors among pregnant women attending an antenatal care (ANC) unit at Simada Hospital, Amhara Region, Northwest Ethiopia. A hospital-based cross-sectional study was conducted on 248 pregnant women from January 2021 to March 2021. Five milliliters of venous blood was collected from each study participant, and serum was tested for Hepatitis B surface antigen (HBsAg), anti-HCV, and anti-HIV antibodies using commercially available rapid test kits. A logistic regression analysis was used to identify possible risk factors for the occurrence of hepatitis and HIV infections. The overall seroprevalence of HBV, HCV, and HIV infections was 10 (4%), 5 (2%), and 5 (2%), respectively. Prevalence of coinfection was 1.2% (3/248), 0.4% (1/248), and 0.4% (1/248) for HBV/HCV, HBV/HIV, and HCV/HIV, respectively. History of abortion (adjusted odds ratio (AOR) = 11.028, 95% confidence interval (CI) = 1.671-72.776, <i>p</i> value = 0.013) and a history of blood transfusions (AOR = 11.298, 95%CI = 1.066-119.777, <i>p</i> value = 0.044) were observed to be significantly associated with an increased risk of HBV infections. However, having multiple sexual partners (AOR = 18.819, 95%CI = 1.074-329.680, <i>p</i> value = 0.045) and history of abortion (AOR = 12.550, 95%CI = 1.174-134.202, <i>p</i> value = 0.036) were the only significant predictors of HCV and HIV infection, respectively. In the current study, we found an intermediate prevalence of HBV and HCV in pregnant women. Therefore, continuous screening of pregnant women for the stated viral infections should be performed to minimize the transmission of the viruses to their children.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"6895237"},"PeriodicalIF":2.6,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and Characterization of a Protease Producing <i>Bacillus cereus</i> Strain From Tannery Waste for Efficient Dehairing of Goat Skin.","authors":"Md Ekhlas Uddin, Md Ramjan Sheikh, Md Asaduzzaman, Sohel Ahmed, Sukalyan Kumar Kundu, Abu Ali Ibn Sina","doi":"10.1155/bmri/7639181","DOIUrl":"https://doi.org/10.1155/bmri/7639181","url":null,"abstract":"<p><p>Environmental pollution has been a significant concern for the last few years. The leather industry significantly contributes to the economy but is one of Bangladesh's most prominent polluting industries. It is also responsible for several severe diseases such as cancer, lung diseases, and heart diseases of leather workers because they use bleaching agents and chemicals, and these have numerous adverse effects on human health. The study was aimed at isolating, identifying, and molecularly characterizing bacteria that produce protease enzymes that are highly capable of dehairing goat hide. Several attempts were made to isolate and identify protease-producing bacterial strains from different soil samples of tannery wastes. Initially, a total of four isolates were selected from tannery soil. After the different phenotypic and morphological characterization, one isolate (BS2) showed Gram-positive, rod-shaped, and spore-forming characteristics and could produce novel hair-degrading protease enzymes. The growth profile and protease activity of the bacteria at 37°C were observed; a basal level of extracellular protease increased with time. The enzyme's proteolytic activity was measured, and the unit of enzyme activity of the enzyme sample was 18.1. The ExPASy server (ProtParam) tool was used to estimate the physicochemical characteristics of the proteins and found molecular weight (MW) (7375.94 Da), aliphatic index (71.56), instability index (II, 80.63), Grand Average of Hydropathy (GRAVY) (-0.231), and isoelectric point (11.41). The protein-protein interactions (PPI) networks were generated using the Search Tool for the Retrieval of Interacting Genes (STRING) database and Cytoscape software. The PSIPRED v.4.0 and SAVES v.6.0 programs were used to determine the secondary and three-dimensional assembly of the selected protein. They found alpha helix (16, 25.00%), extended strand (6, 9.38%), beta-turn (5, 7.81%), and random coil (37, 57.81%). DNA isolation and purification were carried out, and the purity ratio was ~2.17 at 260 and 280 nm. Polymerase chain reaction (PCR) for amplifying the 16S rRNA gene was conducted, and the isolate was authentically recognized as <i>Bacillus cereus</i> (BS2) based on morphological, biochemical, and molecular analyses. The quantitative assessment has shown that 40 mL of culture centrifugation could dehair 2 × 1 cm of goat leather sample in 9 h. This potential bacterial strain can be used in the leather industry as an ecofriendly alternative to chemical dehairing, which can reduce environmental pollution and the risk of severe diseases among leather industry workers.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"7639181"},"PeriodicalIF":2.6,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence of and Associated Risk Factors for Bovine Viral Diarrhea in Dairy Cattle in and Around Nekemte Town, East Wallaga, Oromiya Regional State, Ethiopia.","authors":"Begna Bulcha, Asaminew Tesfaye, Abebe Garoma, Feyisa Begna","doi":"10.1155/bmri/1709145","DOIUrl":"https://doi.org/10.1155/bmri/1709145","url":null,"abstract":"<p><p>Bovine viral diarrhea virus (BVDV) is an important pathogen affecting dairy cattle all over the world by causing significant economic losses due to reproductive and respiratory problems, immunosuppressive effects, increased risk of morbidity, and calf mortality. A cross-sectional study was conducted from February 2021 to August 2021 to determine the seroprevalence of bovine viral diarrhea (BVD) and identify risk factors associated with its occurrence in and around Nekemte Town of Ethiopia. Blood samples were collected from 305 dairy cattle of 41 herds by using cluster-sampling method. All sampled animals were identified by their age, breeds, origin, parity, pregnancy status, and history of reproductive and respiratory problems. Competitive ELISA was used in the laboratory to detect the presence of antibodies in the serum. At the animal and herd level, descriptive statistics were utilized to assess the amount of BVDV viral antibody circulation, and multivariable logistic regression analysis was employed to detect potential risk variables. The result demonstrates 9.84% (95% confidence interval (CI): 6.49-13.18) and 28.52% (95% CI: 23.46-33.59) seroprevalence of BVDV antibody at individual and herd level, respectively. Abortion (odds ratio (OR) = 2.75; <i>p</i> = 0.019), retention of fetal membrane (OR = 3.33; <i>p</i> = 0.011), purchasing of animals (OR = 2.98; <i>p</i> = 0.017), and pregnancy (OR = 3.16; <i>p</i> = 0.019) were variables significantly associated with the seropositivity of BVDV. Herd size was found to be substantially linked with BVDV infection at the herd level (<i>p</i> = 0.009). These moderate seroprevalence of BVDV results indicate that the virus is widely spread among dairy cattle at various farms in and around Nekemte Town, hurting dairy farm production and productivity. To reduce the seroprevalence of this infectious agent, cows with a history of reproductive disorders should be tested, and new animals should be quarantined before being introduced into herds, and more research should be done to assess the impact of reproductive failure and other effects associated with this virus.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"1709145"},"PeriodicalIF":2.6,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Activity of Tea and Agarwood Leaf Extracts Against Multidrug-Resistant Microbes.","authors":"Shah Rucksana Akhter Urme, Syeda Fahmida Ahmed, Md Abdus Shukur Imran, Mst Rubaiat Nazneen Akhand, Mohammad Mehedi Hasan Khan","doi":"10.1155/bmri/5595575","DOIUrl":"10.1155/bmri/5595575","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Emerging multidrug-resistant (MDR) strains are the main challenges to the progression of new drug discovery. To diminish infectious disease-causing pathogens, new antibiotics are required while the drying pipeline of potent antibiotics is adding to the severity. Plant secondary metabolites or phytochemicals including alkaloids, phenols, flavonoids, and terpenes have successfully demonstrated their inhibitory potential against the drug-resistant pathogens. In quest of potential phytochemicals, we selected tea (&lt;i&gt;Camellia sinensis&lt;/i&gt;) and agarwood (&lt;i&gt;Aquilaria malaccensis&lt;/i&gt;) leaves for antimicrobial activity. Fresh tea leaves were collected in three varieties, namely, BT-6, BT-7, and BT-8, including green tea (nonfermented tea), black tea (fully fermented tea), and agarwood leaves collected from Sylhet region of Bangladesh. This study is aimed at analyzing the phytochemical constituency and antimicrobial activity of tea and agarwood leaf extracts and analyzing if there is a combined effect or synergistic activity against multidrug-resistant pathogens. The antimicrobial activity of tea and agarwood leaf extracts was analyzed against MDR pathogenic bacteria and fungus. Qualitative and quantitative phytochemical constituency profiling of these six leaf extracts was evaluated, and preliminary screening exhibited that most of the leaves contained diverse groups of metabolites (alkaloids, tannin, flavonoids, glycosides, saponins, etc.). The highest amounts of TPC (total phenolic content) (110.16 ± 0.48 &lt;i&gt;μ&lt;/i&gt;g/mg) were found in BT-7 in ethanol extracts, and BT-8 in methanol extracts possessed the highest (128.1 ± 0.43 &lt;i&gt;μ&lt;/i&gt;g/mg) TFC (total flavonoid content). Notably, green tea showed remarkable results in TPC and TFC. In antioxidant scavenging activity, BT-7 and green tea showed significant IC&lt;sub&gt;50&lt;/sub&gt; values which were 13.23 and 20.75 mg/mL, respectively. In antimicrobial assays, both 50 &lt;i&gt;μ&lt;/i&gt;L of each tea and agarwood leaf extract antimicrobial activities were examined against 50 &lt;i&gt;μ&lt;/i&gt;L of each bacterial and fungal culture. In synergistic activity, 50 &lt;i&gt;μ&lt;/i&gt;L of each type of leaf extracts was poured over the commercial antibiotics to evaluate their synergism, additive, or antagonism activity against the multidrug-resistant pathogens. In the antimicrobial activity test, green tea showed a maximum diameter (22.0 ± 1.1 mm) zone of inhibition against &lt;i&gt;Klebsiella pneumoniae&lt;/i&gt; whereas BT-8 showed 22.0 ± 2.5 mm against &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt;. Indeed, fresh tea BT-6 and BT-7 both showed remarkable zone of inhibition against the selected microbes including Gram-negative and Gram-positive bacteria. Besides, leaf extract also showed antimicrobial activity against pathogenic fungus &lt;i&gt;Mucor circinelloides&lt;/i&gt;. Aiming to increase antibiotic resistance efficacy, synergistic activities were evaluated among leaf extracts and antibiotics against the selected pathogens where synergism, antagonism, and additive results were noted. ","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"5595575"},"PeriodicalIF":2.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Vitiligo Through Machine Learning and Computer-Aided Techniques: A Systematic Review.","authors":"Sania Tanvir, Sidra Abid Syed, Samreen Hussain, Razia Zia, Munaf Rashid, Hira Zahid","doi":"10.1155/bmri/3277546","DOIUrl":"10.1155/bmri/3277546","url":null,"abstract":"<p><p><b>Background and Objective:</b> Vitiligo is a chronic skin damage disease, triggered by differential melanocyte death. Vitiligo (0.5%-1% of the population) is one of the most severe skin conditions. In general, the foundation of the condition of vitiligo remains gradual patchy loss of skin pigmentation, overlying blood, and sometimes mucus. This paper provides a systematic review of the relevant publications and conference papers based on the subject of vitiligo diagnosis and confirmation through computer-aided machine learning (ML) techniques. <b>Materials and Methods:</b> A search was conducted using a predetermined set of keywords across three databases, namely, Science Direct, PubMed, and IEEE Xplore. The selection process involved the application of eligibility criteria, which led to the inclusion of research published in reputable journals and conference proceedings up until June 2024. These selected papers were then subjected to full-text screening for additional analysis. Research publications that involved application of ML techniques with targeted population of vitiligo were selected for further systematic review. <b>Results:</b> Ten selected and screened studies are included in this systematic review after applying eligibility criteria along with inclusion and exclusion criteria applied on initial search result which was 244 studies based on vitiligo. Priority is given to those studies only which use ML techniques to perform detection and diagnosis on vitiligo-targeted population. Data analysis was carried out only from the selected and screened research articles that were published in authentic journals and conference proceedings. <b>Conclusion:</b> The importance of applying ML techniques in the clinical diagnosis of vitiligo can give more accurate results and at the same also eliminate the need of biased human judgement. Based on a comprehensive examination of the research, encompassing the methodologies employed and the metrics utilized to assess outcomes, it was determined that there is a need for further research and investigation regarding the application of ML algorithm for the detection and diagnosis of vitiligo with different datasets and more feature extraction.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"3277546"},"PeriodicalIF":2.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence and Its Revolutionary Role in Physical and Mental Rehabilitation: A Review of Recent Advancements.","authors":"Amir Rahmani Rasa","doi":"10.1155/bmri/9554590","DOIUrl":"10.1155/bmri/9554590","url":null,"abstract":"<p><p>The integration of artificial intelligence (AI) technologies into physical and mental rehabilitation has the potential to significantly transform these fields. AI innovations, including machine learning algorithms, natural language processing, and computer vision, offer occupational therapists advanced tools to improve care quality. These technologies facilitate more precise assessments, the development of tailored intervention plans, more efficient treatment delivery, and enhanced outcome evaluation. This review explores the integration of AI across various aspects of rehabilitation, providing a thorough examination of recent advancements and current applications. It highlights how AI applications, such as natural language processing, computer vision, virtual reality, machine learning, and robotics, are shaping the future of physical and mental recovery in occupational therapy.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"9554590"},"PeriodicalIF":2.6,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11668540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatics Analysis of Biomarkers and Therapeutic Targets Related to Necroptosis in Intervertebral Disc Degeneration.","authors":"Fan Zhang, Lei Yuan, Heng Ding, Zhenkai Lou, Xingguo Li","doi":"10.1155/bmri/9922966","DOIUrl":"10.1155/bmri/9922966","url":null,"abstract":"<p><p>Necroptosis is a critical process in intervertebral disc degeneration (IDD). This research is aimed at identifying key genes regulating necroptosis in IDD to provide a theoretical basis for early diagnosis and treatment. Transcriptome data from patients with IDD and normal samples were obtained from the GSE34095 and GSE124272 datasets of the Gene Expression Omnibus (GEO) public database. Necroptosis-related genes (NRGs) were sourced from the GeneCards database and literature. Differentially expressed necroptosis-related genes (DE-NRGs) in IDD were identified by intersecting these sources. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were used for gene annotation analysis. The receiver operating characteristic (ROC) curve and nomogram analyses assessed the diagnostic efficiency of DE-NRGs. The miRWalk and starBase databases helped construct the competing endogenous RNA (ceRNA) regulatory network of DE-NRGs. We identified 517 differential genes in tissue and 2974 in blood, with 62 genes in common. DE-NRGs (<i>AIFM1</i>, <i>CCT8</i>, <i>HNRNPA1</i>, <i>KHDRBS1</i>, <i>SERBP1</i>) were identified by intersecting NRGs with these 62 common genes. The ROC curve showed an area under the curve (AUC) > 0.70 for DE-NRGs, and the nomogram indicated that a higher DE-NRG score correlates with a higher risk of IDD. <i>CCT8</i>, <i>KHDRBS1</i>, and <i>AIFM1</i> emerged as potential therapeutic targets for IDD through target drug prediction. qRT-PCR (quantitative reverse transcription polymerase chain reaction), Western blot, and immunohistochemistry confirmed the expression of <i>AIFM1</i>, <i>CCT8</i>, <i>HNRNPA1</i>, <i>KHDRBS1</i>, and <i>SERBP1</i> in patients' nucleus pulposus tissue, suggesting these genes as key targets for IDD risk assessment and drug therapy.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"9922966"},"PeriodicalIF":2.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI-Based Morphometric Comparison of Lower Leg Muscles and Tendons in Individuals With Medial Tibial Stress Syndrome.","authors":"Lucas Nogueira de Oliveira, João Luiz Quagliotti Durigan, Caroline Ribeiro Sanchez, Henrique Mansur, Andressa Beatriz Beltrão Rosa, Rita de Cássia Marqueti","doi":"10.1155/bmri/8827692","DOIUrl":"10.1155/bmri/8827692","url":null,"abstract":"<p><p>Runners frequently suffer from medial tibial stress syndrome (MTSS), often linked to excessive eccentric muscle contractions causing periosteal traction by the muscles in the deep posterior compartment. However, the effects of MTSS on these muscles and tendons remain underexplored. This study is aimed at investigating changes in muscle and tendon volumes in this compartment, as well as cross-sectional area measurements, using magnetic resonance imaging. Thirty individuals were divided into two groups: MTSS (<i>n</i> = 18; mean age 30.3 ± 12.4) and control (<i>n</i> = 12; age 35.2 ± 9.2). The anterior, deep posterior, superficial posterior, and lateral compartment muscles, along with their respective tendons, were compared between groups, and possible sex differences were also evaluated. The deep posterior compartment showed a significant volume difference of 0.41 cm³/kg³/⁴ in the MTSS group (<i>p</i> = 0.034), primarily due to the flexor hallucis longus (FHL), which had a 0.55 cm³/kg³/⁴ greater normalized volume (17.12% greater mean muscle volume) compared to controls (<i>p</i> = 0.023; Cohen <i>d</i> = 0.895). No association between sex and MTSS was found (<i>p</i> = 0.752). In conclusion, the FHL muscle exhibited increased normalized volume in the MTSS group compared to controls, with no sex-related differences in MTSS. Clinicians should consider the assessment of FHL muscle volume in routine evaluations of patients presenting with symptoms suggestive of MTSS.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"8827692"},"PeriodicalIF":2.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Antimicrobial and Anti-Biofilm Activities of <i>Thymus fallax</i> Essential Oil against Oral Pathogens\".","authors":"Maryam Moshaverinia, Sarina Sahmeddini, Fatemeh Lavaee, Zahra Zareshahrabadi, Kamiar Zomorodian","doi":"10.1155/bmri/9797835","DOIUrl":"10.1155/bmri/9797835","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/2022/9744153.].</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"9797835"},"PeriodicalIF":2.6,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Impact of Biological Agents on Protecting Against Experimental Periodontitis: A Systematic Review of Animal-Based Studies.","authors":"Gabriela Ezequiel Oliveira, Davi da Silva Barbirato, Bruna Silva de Menezes, Milenna Silva Fuly, Henrique Cassebe Ledo Pelegrine, Debora Caliendo Bonilha, Julia Gabrielle Pereira de Alencar, Leticia Helena Theodoro, Rafael Scaf de Molon","doi":"10.1155/bmri/1716735","DOIUrl":"10.1155/bmri/1716735","url":null,"abstract":"<p><p><b>Aim:</b> This systematic review was aimed at addressing the focused question: What is the protective potential of biological agents against alveolar bone resorption during the progression of experimental periodontitis (EP)? <b>Material and Methods:</b> The study protocol was registered in the Open Science Framework database (doi:10.17605/OSF.IO/3P2HY). A comprehensive literature search was conducted across PubMed, Web of Science, Cochrane Library, Scopus, and Embase databases up to December 2023. Inclusion criteria consisted of preclinical studies in animal models of EP that examined the effects of biological agents on preventing periodontal bone loss and reducing tissue inflammation. Studies were excluded if they (i) used non-EP animal models; (ii) focused on antimicrobial agents; (iii) centered on prebiotics or probiotics; (iv) evaluated compounds not classified as biologicals; or (v) included randomized clinical trials, clinical studies, or reviews. Eligibility was determined based on the PI/ECOs framework, and study quality was assessed using the SYRCLE risk-of-bias tool. <b>Results:</b> After screening an initial pool of 5236 records from databases, registries, and hand searches, 39 studies met the inclusion criteria. A total of 23 biological agents were evaluated across these studies. The majority of studies employed the ligature-induced model of EP to test the effectiveness of biologicals as preventive or therapeutic interventions. The dosage of biological agents and the duration of disease induction varied depending on the EP model. In all studies, the main outcome-alveolar bone loss, a hallmark of EP-was significantly inhibited by biological agents, which also reduced proinflammatory mediators when compared to untreated controls. A key strength of this review is the high number of studies included, most of which were classified as having low risk of bias. However, a notable limitation is the absence of a meta-analysis, the short follow-up periods in the included studies, and the heterogeneity among the compound dosages and route of administration. <b>Conclusion:</b> This systematic review demonstrates that biological agents are effective in reducing bone loss and mitigating inflammation during EP progression. Randomized clinical trials are needed to confirm these findings in human populations.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"1716735"},"PeriodicalIF":2.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}