BioMed Research International最新文献

{"title":"Study on the Molecular Prevalence and Genotypic Distribution of Torque Teno Virus in Iranian Hemodialysis Patients.","authors":"Amin Naseri, Enayat Anvari, Seyyedeh Masumeh Mirnurollahi, Abolfazl Fateh","doi":"10.1155/bmri/2504873","DOIUrl":"https://doi.org/10.1155/bmri/2504873","url":null,"abstract":"<p><p>This case-control study investigated the prevalence, genotypic distribution, and associated factors of Torque Teno Virus (TTV) infection in a cohort of 1576 hemodialysis (HD) patients compared to 1000 healthy individuals in Iran. This study is aimed at assessing the epidemiological profile of TTV, while also exploring its relationship with coinfections and various demographic factors, given the unclear clinical significance of TTV. Nested PCR and sequencing techniques were utilized to identify TTV DNA and its genotypes. The prevalence of TTV was significantly higher in patients undergoing HD, at 51.8%, compared to just 11.5% in healthy individuals. Coinfections were also notable, with 16.8% of HCV-positive, 5.3% of HBV-positive, and 3.0% of HIV-positive HD patients also carrying TTV. Genotypic analysis revealed distinct distributions: Genotypes 3, 17, 11, and 13 were more common in HD patients, while Genotypes 1, 3, and 17 were more prevalent in controls. Additionally, there was a significant correlation between advanced age and longer dialysis duration with TTV positivity. Variations in TTV prevalence across different studies emphasize the influence of methodological and geographical factors, underscoring the need for standardized diagnostic approaches. While the pathogenicity of TTV remains unclear, its potential as an indicator of immune compromise or coinfection risk warrants further investigation. This study highlights the need for enhanced monitoring in HD units to reduce transmission and stresses the importance of long-term research to clarify TTV's clinical significance. The findings emphasize the need for tailored infection control measures for high-risk groups, particularly in regions with a higher prevalence of HCV/HBV.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"2504873"},"PeriodicalIF":2.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12289367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Comparison of Biochemical Parameters between Mouse Model and Human after Paraquat Poisoning\".","authors":"","doi":"10.1155/bmri/9827387","DOIUrl":"https://doi.org/10.1155/bmri/9827387","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/2022/1254824.].</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"9827387"},"PeriodicalIF":2.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Suppression of KIF22 Inhibits Cell Proliferation and Xenograft Tumor Growth in Tongue Squamous Cell Carcinoma.","authors":"BioMed Research International","doi":"10.1155/bmri/9874693","DOIUrl":"10.1155/bmri/9874693","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2020/6387545.].</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"9874693"},"PeriodicalIF":2.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capillary Blood Self-Sampling for Therapeutic Drug Monitoring: A Mixed-Methods Usability Study of the True Dose^® Kit.","authors":"Marie-Therése Crafoord, Elham Hedayati, Aina Johnsson","doi":"10.1155/bmri/9973081","DOIUrl":"10.1155/bmri/9973081","url":null,"abstract":"<p><p><b>Objective:</b> This study evaluates the usability in accordance with EN 62366 of the True Dose kit for capillary blood self-sampling, to be used to analyze, specify, design, verify, and validate usability as it relates to the safety of medical devices focusing on user performance, experience, and user confidence through a mixed-methods approach. The usability engineering process is needed to fulfill user interface design requirements as part of product development at True Dose kit. <b>Methods:</b> The study employed a convergent parallel design, integrating quantitative and qualitative data. Twenty-five participants, recruited through convenience sampling, used the True Dose kit to perform capillary blood self-sampling. Quantitative data were collected using three key performance metrics-collection of sufficient blood volume, absence of air bubbles, and duration of the self-sampling process-along with two questionnaires, the System Usability Scale (SUS) and the Test Feedback Questionnaire (TFQ), to comprehensively assess user performance and experience. In contrast, qualitative data were obtained from interviews and free-text responses. The integration of findings highlighted areas of convergence and divergence between the quantitative and qualitative data. <b>Results:</b> The overall SUS score was 82.70, indicating high usability. However, participants reported challenges with the complexity of instructions and stress associated with blood flow management. Qualitative insights revealed a preference for simplified visual guidance and highlighted the need for precise feedback mechanisms to ensure the correct execution of sampling steps. Despite these challenges, 92% of participants collected the required blood sample, with a median self-sampling duration of 10.42 min. <b>Conclusion:</b> The True Dose kit demonstrates high usability potential, but improvements in instructional design and stress management are needed to enhance user experience and ensure consistent performance. <b>Trial Registration:</b> EUCT Number: 2024-514818-12-00.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"9973081"},"PeriodicalIF":2.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Microgap Size and Microbial Microleakage at the Implant Fixture-Abutment Interface in Original and Compatible Abutments.","authors":"Reza Sharifi, Tahereh Ghaffari, Shima Ghasemi, Hossein Samadi Kafil","doi":"10.1155/bmri/2530986","DOIUrl":"10.1155/bmri/2530986","url":null,"abstract":"<p><p><b>Introduction:</b> The microgap between implant and abutment can lead to mechanical and biological problems such as abutment screw breakage or peri-implantitis. The utilization of compatible abutments in place of the original components results in a decrease in costs and provides dentists with a broader selection of abutment options. The purpose of this study was to compare bacterial microleakage and microgap in the Korean Osstem, Dio, and Cis systems, whose regular abutments are compatible with each other. <b>Method:</b> Twelve implant abutments were used in this study, each four from Osstem (Seoul, South Korea), Dio (Seoul, South Korea), and Cis (Medimecca, Seoul, South Korea), all measuring 7 mm in length, 4.5 mm in diameter, and 3 mm in height. These were attached to Osstem fixtures of regular size (4.5 mm diameter and 11.5 mm length), which were contaminated with a bacterial suspension. Bacterial contamination was assessed at 5, 24, and 48 h, while microgap size was measured at four points using an electron microscope. Statistical analyses, including one-way ANOVA and the Kruskal-Wallis tests, were performed by SPSS 17 to evaluate differences in microgap and microleakage among the groups. <b>Results:</b> There is a statistically significant difference between the mean microgap in the Dio group and the other two groups. The mean microgap in the Dio group was higher than both of the other groups (<i>p</i> value < 0.001). There is no statistically significant difference between the mean microgap in the Osstem group and its mean in the Cis group (<i>p</i> value > 0.05). There was no statistically significant difference between the mean number of colonies (CFU) in the study groups at any of the four evaluation times (<i>p</i> value > 0.05). <b>Conclusion:</b> Considering the limitations of this study, it can be inferred that the Cis-compatible abutment is also applicable for use with the Osstem fixtures.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"2530986"},"PeriodicalIF":2.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Analysis of Clinical Characteristics of 556 Spinal Tuberculosis Patients in Two Tertiary Teaching Hospitals in Guangxi Province\".","authors":"","doi":"10.1155/bmri/9808104","DOIUrl":"https://doi.org/10.1155/bmri/9808104","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/2021/1344496.].</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"9808104"},"PeriodicalIF":2.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Universal Adhesive Etching Mode on Shear Bond Strength of Pulp Capping Materials to Deep Dentin.","authors":"Shahram Amirifar, Saba Tohidkhah, Seyedeh Mahsa Sheikh-Al-Eslamian, Mahdi Abbasi, Fatemeh Farshad, Elham Ahmadi","doi":"10.1155/bmri/1496726","DOIUrl":"10.1155/bmri/1496726","url":null,"abstract":"<p><p><b>Objective:</b> This study was aimed at investigating the shear bond strength (SBS) of composite to deep dentin with universal adhesive in total-etch (TE) and self-etch (SE) mode using different pulp capping materials. <b>Methods:</b> One hundred twelve sound human third molars were divided according to universal adhesives (All-Bond Universal and G-Premio Bond), etching modes (TE and SE), and pulp capping materials (TheraCal PT, TheraCal LC, and Lime-Lite). After sectioning the tooth 2 mm above and 3 mm below the CEJ, the liner, adhesive, and composite were applied. Specimens were tested for SBS using the universal testing machine at a crosshead speed of 1 mm/min after restoring with composite. Data were analyzed with three-way ANOVA (<i>α</i> = 0.05). <b>Results:</b> The highest and lowest SBS value was related to G-Premio bonding adhesive in SE mode using Lime-Lite (11.91 ± 0.77) and G-Premio bonding adhesive in SE mode using TheraCal PT (4.48 ± 0.83), respectively. Although the type of adhesive material did not have a significant impact on SBS values (<i>p</i> = 0.58), the mode of acid etching (<i>p</i> = 0.001) and the type of liner (<i>p</i> = 0.001) used were found to have a significant effect. Moreover, TE mode was associated with higher SBS values than SE mode. <b>Conclusions:</b> Using TE mode increased the SBS; in contrast, liners reduced the SBS of the composite to deep dentin. Moreover, other generations of adhesives and comparison with universal bonding should be done in future studies.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"1496726"},"PeriodicalIF":2.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the Therapeutic Potential of <i>Piper chaba</i> Hunter: Computational Approaches Shed Light on Targeting Proteins in Alzheimer's Disease.","authors":"Md Sifat Rahi, Md Shahedur Rahman, Rima Islam Meem, Md Ebrahim Khalil Shimul, Nahid Farnaj, Md Humaun Kabir, Fee Faysal Ahmed, Md Anowar Khasru Parvez, Md Amdadul Huq, Tabassum Kabir, Abdel Halim Harrath, Mahadi Hasan, Md Ataur Rahman","doi":"10.1155/bmri/8892801","DOIUrl":"10.1155/bmri/8892801","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a prevalent neurodegenerative disorder, while the existing treatments primarily focus on alleviating symptoms rather than addressing the underlying pathophysiology. Seeking a safer alternative, the study explores the potential of <i>Piper chaba</i> Hunter as a promising drug lead for AD by eliciting the major signaling pathway, key players, and their interaction with phytochemicals from the plant extract. Initially, the phytochemicals in the <i>P. chaba</i> crude extract were identified using GC-MS, and their physicochemical properties were verified using SwissADME. Protein-protein interaction (PPI) and signaling pathways-target proteins-compounds (STC) networks were analyzed to dig out target proteins and effective compounds for AD based on rigorous screening. Approximately 60 target proteins that interacted with GC-MS-identified compounds underwent PPI and STC networking which identified five compounds, a signaling pathway, and three target proteins with therapeutic potential. Three compounds, namely, bicyclo[7.2.0]undec-4-ene, 4,11,11-trimethyl-8-methylene-,[1R-(1R∗,4Z,9S∗)], 2-methoxybenzoic acid, 2,3-dichlorophenyl ester, and (E)-3-butylidene-4,5-dihydroisobenzofuran-1(3H)-one, have the potential to modulate PTGS2, PLA2G4A, and CYP2C19 within metabolic signaling pathway, thus serving as promising therapeutic agents. Moreover, the drug likeliness and efficacy of those phytochemicals were justified by molecular docking tests (MDTs), molecular dynamics simulations (MDSs), and quantum chemistry analyses, which confirmed their ability to inhibit key targets to mitigate AD-associated pathology.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"8892801"},"PeriodicalIF":2.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presence of Sildenafil and Tadalafil in Herbal Medicinal Products Claimed to Treat Erectile Dysfunction in Nyamagana and Ilemela Districts, Mwanza, Tanzania.","authors":"Flora J Mchallah, Raphael Matinde, Adelina Thomas, Lutugera Kihwili, Tanga Mafuru, James Kapala, Emmanuel Kimaro, Alfredi A Moyo, Eugene Mutagwaba, Sheila M Maregesi","doi":"10.1155/bmri/8222227","DOIUrl":"10.1155/bmri/8222227","url":null,"abstract":"<p><p><b>Background:</b> Herbal products are increasingly utilized for various conditions, including erectile dysfunction (ED), due to their minimal side effects, affordability, and natural properties. Phosphodiesterase type 5 inhibitors (PDE 5is) such as sildenafil citrate, tadalafil, vardenafil hydrochloride, and avanafil are synthetic oral medications approved for ED treatment. However, multiple studies have highlighted the contamination of herbal aphrodisiacs with PDE 5i or their conventional analogs. This study evaluated the contamination of aphrodisiac-claimed herbal products available in Mwanza, Tanzania. <b>Method:</b> A total of 40 herbal product samples were collected from local vendors and analyzed by high-performance thin layer chromatography (HPTLC). Chromatography was performed on a 20 × 10 cm aluminum-backed plate coated with analytical-grade silica gel 60 F₂₅₄. The plates were developed on a 20 × 20 cm 30-min presaturated twin trough tank containing chloroform (9 mL), methanol (1 mL), and diethylamine (0.1 mL) as the mobile phase. The developed plates were scanned at the wavelengths of 292 and 284 nm for sildenafil and tadalafil, respectively. <b>Results:</b> Out of 40 herbal product samples analyzed, 25 samples (62.5%) were found to be adulterated. Among the adulterated samples, 2 (8%) were contaminated with sildenafil, 9 (36%) with tadalafil, and 14 (56%) with both sildenafil and tadalafil. Quantitative analysis indicated that two samples (12.5%) of the sildenafil-adulterated samples contained an amount of sildenafil that exceeded the maximum recommended daily dose of 100 mg. <b>Conclusion:</b> Aphrodisiac-claimed herbal medicinal products are adulterated with conventional medicines, sildenafil and tadalafil. Alarmingly, some of these products contain higher amounts of these pharmaceutical agents beyond the maximum daily dose.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"8222227"},"PeriodicalIF":2.6,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12253990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normative Values and Test/Retest Reliability of a New Test: Spatial Processing of Sentences in Noise in Portuguese.","authors":"Leticia Reis Borges-Ifanger, Bruno Sanches Masiero, Maria Francisca Colella-Santos","doi":"10.1155/bmri/7880012","DOIUrl":"10.1155/bmri/7880012","url":null,"abstract":"<p><p><b>Objective:</b> This article establishes normative values for children and analyzes test-retest results for a new test, the Spatial Processing of Sentences in Noise in Portuguese (PROSER). <b>Methods:</b> To establish normative criteria, we evaluated 66 Brazilian Portuguese-speaking children aged 7-10 years using audiological assessments, school performance tests, and the PROSER test. A subset of 22 children participated in a test-retest evaluation. <b>Results:</b> Examining all 66 participants, we found significant differences in the speech reception threshold (SRT) means between the 0° and ±90° interference conditions when analyzing all four test conditions. Considering the age group, the performance of 10-year-old children was superior to that of both 7- and 8-year-old children. Test-retest comparison showed slight improvements (0.11-1.13 dB) in the retest phase across most conditions and advantage measures. The difference between the average SRT in the test and retest was statistically significant only in Condition 3-DV0°. <b>Conclusions:</b> The study established normative values for children aged 7-10 years, confirming PROSER as a procedure with adequate test-retest reliability.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"7880012"},"PeriodicalIF":2.6,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}