BioMed Research International最新文献

{"title":"The Prevalence of Malaria Among Pregnant Women at a Tertiary Care Hospital in Somalia: A Cross-Sectional Study.","authors":"Said Mohamed Mohamud, Serpil Doğan, Ahmed Issak Hussein, Rahma Yusuf Haji Mohamud, Zerife Orhan, Adem Doğaner","doi":"10.1155/bmri/6730167","DOIUrl":"10.1155/bmri/6730167","url":null,"abstract":"<p><p><b>Background:</b> In countries like Somalia, where health infrastructure is inadequate and malaria is endemic, immunosuppression during pregnancy increases the risk of placental malaria; this, in turn, leads to anemia, low birth weight, preterm delivery, and stillbirth, causing severe complications that pose a life-threatening risk to both the mother and fetus. <b>Aim:</b> The aim of this study was to investigate the prevalence and associated factors of malaria parasitemia among pregnant women attending the obstetric clinic of a tertiary hospital in Somalia. <b>Method:</b> This cross-sectional study, conducted from November 2022 to January 2023 at a tertiary hospital in Mogadishu, involved 398 pregnant women. Both symptomatic and asymptomatic participants were screened for malaria using Giemsa-stained blood smear microscopy. Associations between variables and malaria prevalence were analyzed using IBM SPSS 22 with chi-square tests and logistic regression. <b>Results:</b> Among 398 pregnant women, 238 (59.8%) tested positive for malaria. Of the 238 malaria cases, 218 (91.6%) were revealed as <i>Plasmodium falciparum</i> cases. Being in the second trimester (OR: 0.524, 95% CI: 0.279-0.983; <i>p</i> = 0.044), third trimester (OR: 0.442, 95% CI: 0.245-0.797; <i>p</i> = 0.007), and indoor residual spraying (IRS) (OR: 0.192, 95% CI: 0.108-0.342; <i>p</i> < 0.001) were significantly associated with decreased odds of malaria in pregnancy. <b>Conclusion:</b> The study revealed a high prevalence of malaria in pregnancy, predominantly caused by <i>Plasmodium falciparum</i>. Targeted education campaigns focusing on women in the second trimester and those not using preventive measures such as IRS or ITNs should be prioritized, along with routine malaria screening at every antenatal care visit.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"6730167"},"PeriodicalIF":2.3,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy and Reproducibility of Semidigital Versus Fully Digital Cephalometric Tracings Using a New Computer Program Versus Conventional Methods (Gold Standards): A Preliminary Study.","authors":"Farhad Sobouti, Sepideh Dadgar, Sina Namadian, Hamid Reza Bahrami Rad, Vahid Rakhshan","doi":"10.1155/bmri/8403357","DOIUrl":"https://doi.org/10.1155/bmri/8403357","url":null,"abstract":"<p><p><b>Introduction:</b> Cephalometric tracing can be done either conventionally or using computers. Digital dentistry and digital orthodontics have considerably facilitated procedures. Still, their diagnostic accuracy needs assessment. Many orthodontic programs have been developed for this purpose. The efficacy and reliability of such software are usually compared with the conventional method (gold standard). We used novel and more stringent methods of assessment to test a program in this regard. <b>Methods:</b> This study was performed on 10,302 tracing evaluations within 101 cases. Lateral cephalograms of 101 patients were landmarked using two methods (on paper vs. on a computer screen) and traced using three methods (completely conventionally [gold standard]; landmarks were identified on paper, but measurements were calculated by computer; landmarks were identified on the computer screen, and measurements were calculated by the computer program). A total of 15 landmarks and 17 cephalometric tracing measurements were determined via the abovementioned methods. The tracing errors were defined as differences between each pair of tracing methods, as well their absolute values (a total of 6 different tracing errors). Intraclass correlations were calculated for tracing values. Tracing errors were compared with the value 2, as the clinically acceptable range. However, they were also compared with the values zero as well as one hundredth of the mean of gold standard (as a more conservative value), using a one-sample <i>t</i>-test (<i>α</i> = 0.05). <b>Results:</b> All tracing errors were smaller than the clinically acceptable limits. Moreover, most simple errors were close to zero, and/or below the criterion of 1/100 of the mean of the gold standard. Furthermore, the more difficult error tests, that is, the directionless absolute errors, were all below 2; additionally, they were either below the 1/100 of absolute of the gold standard means or at the level of those means. Finally, the intraobserver reliabilities were high. All the 102 simple errors and absolute errors (on 101 lateral cephalograms) were significantly below 2 (<i>p</i> < 0.0005, clinically acceptable). <b>Conclusions:</b> The accuracy was appropriate. Of the 51 simple tracing errors, only 9 were significantly greater than zero, and many of them were below or at the level of 1/100 of the gold standard means. All the directionless (absolute) errors were significantly greater than zero. However, in the case of those calculated as \"absolute value of (gold standard subtracted by fully digital method),\" all errors were below or at the level of 1/100 of the absolute of gold standards' means. The intraobserver reliabilities were high.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"8403357"},"PeriodicalIF":2.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12377959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IER5 Negatively Regulates Cdc25B Expression in HeLa Cells After Gamma Ray Irradiation.","authors":"Xianzhe Zhao, Lixin Ding, Yongzhong Ma, Wei Cheng, Li Zhang, Kuke Ding","doi":"10.1155/bmri/5644318","DOIUrl":"https://doi.org/10.1155/bmri/5644318","url":null,"abstract":"<p><p>Radiotherapy is commonly used to treat many cancers, and their sensitivity to radiation is crucial for favorable outcomes. This study investigated whether the immediate early response 5 (IER5) protein affects Cdc25B protein expression in HeLa cells after gamma irradiation. IER5 was knocked down using RNA interference (RNAi) in HeLa cells irradiated with 2 or 4 Gy of gamma rays. The mRNA and protein expression levels were subsequently determined via qRT-PCR and western blotting. The distribution of cells during the cell cycle was also determined using flow cytometry. IER5 protein levels were successfully reduced with RNAi. Variations in IER5 levels led to differences in Cdc25B mRNA and protein levels. Moreover, IER5 affected the proportion of cells in the G2 phase, which is regulated mainly by Cdc25B. Pearson correlation analysis was conducted on the expression levels of IER5 and Cdc25B in HeLa cells and the IER5-silenced HeLa (siIER5-HeLa) cell line at various time points after exposure to 4 Gy of gamma rays, and a negative correlation was detected between IER5 and Cdc25B expression levels, with correlation coefficients of -0.686 and -0.663, respectively. Additionally, variations in IER5 levels led to differences in the expression levels of p53, NF-YB, and p300, which may be putative transcriptional regulators of Cdc25B. These results suggest that IER5 plays a negative role in regulating Cdc25B expression, which may involve interactions with the transcriptional regulators p53, NF-YB, and p300.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"5644318"},"PeriodicalIF":2.3,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12370387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Synergistic Effects of Caffeine and Naringin on Mitochondrial Biogenesis and Hepatic Steatosis in Adult Male Rats With NAFLD Induced by a High-Fat Diet.","authors":"Mehrasa Azizollahi, Zahra Nasehi, Maryam Derakhshan, Fouzieh Zadhoush","doi":"10.1155/bmri/1565994","DOIUrl":"https://doi.org/10.1155/bmri/1565994","url":null,"abstract":"<p><p><b>Introduction:</b> Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide, and disturbances in lipid metabolism and mitochondrial function play a significant role in its progression. In this study, to improve the effects of caffeine (CAF) treatment, we evaluated the effects of CAF and naringin (NAR) alone and in combination on gene expression involved in mitochondrial biogenesis, plasma nonesterified fatty acid (NEFA) levels, hepatic TG levels, and pathological changes in the liver tissue in adult male rats with NAFLD induced by a high-fat diet (HFD). <b>Materials and Methods:</b> Then, 35 male Wistar rats were randomly assigned to five groups: control, HFD, HFD + CAF, HFD + NAR, and HFD + CAF + NAR (seven rats per group). They were fed a HFD containing 51% fat for 10 weeks, followed by a 6-week gavage treatment with CAF (50 mg/kg/day) and NAR (12.5 mg/kg/day), either individually or in combination. Gene expression related to mitochondrial biogenesis (SIRT1, PGC1<i>α</i>, and TFAM), serum NEFA levels, hepatic triglyceride (TG) levels, and liver histological changes were assessed. <b>Findings:</b> The combination of CAF and NAR in the HFD + CAF + NAR group significantly increased the expression of SIRT1 (<i>p</i> < 0.01), PGC1-<i>α</i> (<i>p</i> < 0.01), and TFAM (<i>p</i> < 0.05) compared to the HFD group, while single treatments did not show such effects. Serum NEFA levels did not change significantly in any of the groups (HFD and treatment groups), but liver TG levels were significantly reduced in both single and combination treatments (<i>p</i> < 0.001). Pathological changes, including improvements in steatosis, inflammation, and ballooning, were observed in the treatment groups, particularly in the HFD + CAF + NAR group. <b>Conclusion:</b> Based on current findings, the combined use of CAF and NAR as an adjunct therapy may exert its protective effects by enhancing the expression of genes involved in mitochondrial biogenesis, improving liver lipid levels, and ameliorating liver pathology. Therefore, it can be considered an innovative strategy for improving liver metabolic status in the context of NAFLD.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"1565994"},"PeriodicalIF":2.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Fructose-Enhanced Solid and Soft Drink Diets on Metabolism, Physiology, and Gut Microbiome in Pregnant Rats.","authors":"Xiaoyuan Han, Linda D Shortliffe, Neeraja Kambham","doi":"10.1155/bmri/6902453","DOIUrl":"https://doi.org/10.1155/bmri/6902453","url":null,"abstract":"<p><p><b>Introduction:</b> High fructose consumption is linked to hypertension and metabolic disorders. We hypothesize fructose (solid and/or liquid) may further influence dietary patterns. To investigate potential effects, we compared eating behaviors, physiological and metabolic measures, and gut microbiome in pregnant rats fed solid or liquid fructose-enhanced (soft drink) diets to those fed standard chow. <b>Methods:</b> Pregnant rats were assigned to three dietary groups: (1) standard chow and water (CW), (2) standard chow and decarbonated soft drink (CS, decarbonated Sprite with 5.89% fructose <i>w</i>/<i>v</i>), and (3) 60% fructose chow and water (FW). Body weight, blood pressure, food and liquid intake, fasting blood glucose, plasma insulin, and lipid profiles were measured weekly. Fecal samples were collected before and during pregnancy. At euthanasia, livers and kidneys were analyzed for pathological changes. <b>Results:</b> Data from five rats per group were analyzed. The CS group showed nearly a twofold increase in fluid intake and urinary output at midpregnancy. Both solid and liquid fructose groups had increased carbohydrate calorie intake per kilogram of body weight, while protein and fat intake decreased. Although all rats showed pregnancy-related dyslipidemia, the FW group experienced a more pronounced increase. Pregnancy and the FW diet also led to distinct shifts in the fecal gut microbiome. <b>Conclusions:</b> This pregnant rat model highlights the impact of varying fructose diets during physiological stress. Pregnant rats on high-fructose diets (CS, FW) increased their carbohydrate intake at the expense of protein and fat intake when compared with pregnant rats on a routine diet. CS rats showed a marked increase in soft drink intake and urine. These findings have potential nutritional and health implications for pregnancy and long-term health and warrant further investigation and confirmation.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"6902453"},"PeriodicalIF":2.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Urethral Tissue Reconstruction Using the Acellular Dermal Matrix Patch Modified with Collagen-Binding VEGF in Beagle Urethral Injury Models.","authors":"BioMed Research International","doi":"10.1155/bmri/9817873","DOIUrl":"https://doi.org/10.1155/bmri/9817873","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2021/5502740.].</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"9817873"},"PeriodicalIF":2.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Analysis of an Immune-Related Gene Signature for Predicting Prognosis and Immune Characteristics in Primary Lower Grade Glioma.","authors":"Liubing Hou, Lei Tian, Jiayuan Li, Zizhou Zhang, Xuetao Han, Huandi Zhou, Xiaoying Xue","doi":"10.1155/bmri/6180391","DOIUrl":"https://doi.org/10.1155/bmri/6180391","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Background:&lt;/b&gt; Immune-related genes (IRGs) have been increasingly recognized as critical determinants in the multistage processes of cancer development and progression. However, the functional roles of IRGs in the incidence and progression of LGG remain to be studied. This study is aimed at establishing a robust IRGs signature through systematic bioinformatics analysis, followed by an in-depth investigation of the molecular mechanisms underlying its functional roles. A key objective is to dissect the intricate interplay between IRGs expression patterns and the composition/functional orientation of tumor-infiltrating immune cells inside the tumor microenvironment. Furthermore, our findings are aimed at providing novel evidence to facilitate molecular diagnosis and advance immunotherapeutic strategies for LGG. &lt;b&gt;Methods:&lt;/b&gt; RNA sequencing datasets, accompanied by detailed and pertinent clinical information pertinent to LGG, were meticulously retrieved from databases including TCGA and CGGA. To measure the levels of immune cell distribution across the specimens, we employed the sophisticated ssGSEA, which incorporated 29 immune infiltration-related information, enabling stratification of cases into immunity-low (immunity_L) and immunity-high (immunity_H) clusters. This classification provided crucial insights for understanding the immune landscape of LGG and its potential clinical implications. To further investigate, we identified differentially expressed IRGs by intersecting the list of DEGs with the IRGs curated from the ImmPort website. Subsequent feature selection employed Cox proportional hazards regression and LASSO regression to derive a prognostic IRGs signature in the TCGA cohort. This model facilitated risk stratification of patients into low-risk and high-risk subgroups. The established signature's predictive efficacy was rigorously validated in the CGGA cohort through comprehensive analytical approaches. This included Kaplan-Meier survival analysis for prognostic stratification, time-dependent receiver operating characteristic (ROC) curve construction for quantifying predictive accuracy, principal component analysis (PCA) for visualizing sample distribution patterns, and subgroup stratification to assess consistency across clinical variables. Additionally, ssGSEA was utilized to profile the TME, and correlation analyses were performed between the IRG-derived risk score and immune checkpoint expression levels. &lt;b&gt;Results:&lt;/b&gt; Finally, we selected CXCL10, ICAM1, IL18, ITGAL, SOCS3, and TLR3 to establish a six-gene IRGs signature for LGG. Based on this feature, we divided patients into low- and high-risk subgroups and found that high-risk patients consistently exhibited shorter OS. Notably, the risk score based on this signature emerged as an independent predictor of OS. TME analysis showed more immune infiltration in the high-risk subgroup. Correlation analysis further revealed a strong positive association between the risk sc","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"6180391"},"PeriodicalIF":2.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Assessment of Apoptotic and Cell Cycle Arrest Analysis on HepG2 Cells by Polyethylene Glycol-Coupled Selenium Nanocomposite Fabricated From <i>Cassia fistula</i> Flowers.","authors":"Senthamaraikannan Yasodha, Sundaram Vickram, Shanmugam Rajeshkumar, Hitesh Chopra, Tabarak Malik","doi":"10.1155/bmri/6212199","DOIUrl":"10.1155/bmri/6212199","url":null,"abstract":"<p><p>Polymer-encapsulated nanocomposite has been proven to have ameliorative effects in the treatment of cancer. The focused objective of the present research is to fabricate polyethylene glycol (PEG)-based <i>Cassia fistula</i> flower selenium nanocomposite (CFF-SeNC). The fabricated CFF-SeNC was characterised using a UV-visible spectrophotometer, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM)-energy dispersive x-ray (EDX), and x-ray diffractometer (XRD) analysis. The highest UV-visible absorption spectra were at 355 nm. The oval-shaped, less agglomerated nanocomposite with a rough surface was seen in the SEM results with the elemental composition of carbon, oxygen, and selenium. The XRD analysis results showed the crystalline form of CFF-SeNC. The potency of CFF-SeNC against pathogenic bacteria and fungi proved that CFF-SeNC is effective against the tested fungi <i>Candida albicans</i>. The antioxidative assays-DPPH, ABTS, and H₂O₂ of CFF-SeNC-revealed the inhibition percent of 85.51% ± 0.79%, 90.53% ± 0.90%, and 84.87% ± 0.80% at maximum concentration (50 <i>μ</i>g/mL), respectively. The anti-inflammatory efficiency of CFF-SeNC was found to be 80.61% ± 0.87% and 87.78% ± 0.88% by egg albumin denaturation and HRBCs (human red blood cells) membrane stabilisation assay. The biocompatible nature of CFF-SeNC was tested by brine shrimp lethality activity, which proved that at 48 h, the minimal dose was not toxic; however, mild toxicity was shown at a higher dosage. The anticancer studies of CFF-SeNC in HepG2 cells were active in inhibiting 50% of cells (IC₅₀ value) at 27.30 <i>μ</i>g/mL. HepG2 cells depicted predominant morphological changes upon treatment with CFF-SeNC, whereas there was no alteration in <i>Vero</i> cells. The elaborative study on determining the phases of cell apoptosis was further analysed by fluorescence microscopy, cell cycle arrest, and Annexin V/propidium iodide staining through flow cytometric analysis. The outcome of current research has corroborated the enhanced therapeutical efficiency of PEG-encapsulated selenium nanocomposite with emphasis on the apoptotic effect in hepatocellular carcinoma (HepG2 cells).</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"6212199"},"PeriodicalIF":2.3,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Self-Reported Practices on Food Safety Among Female Food Handlers of Households in Budhiganga Rural Municipality, Nepal.","authors":"Jibesh Acharya, Pravat Uprety","doi":"10.1155/bmri/3233795","DOIUrl":"10.1155/bmri/3233795","url":null,"abstract":"<p><p>This study examines the level of self-reported food safety practices and the factors associated with them. Using a structured questionnaire, this study was conducted among 335 female household food handlers in the Budhiganga Rural Municipality, Nepal. The overall level of the practice was assessed through 14 questions on a 3-point scale (1 = <i>always</i>, 2 = <i>sometimes</i>, and 3 = <i>never</i>) where the mean cumulative score was taken as the cut-off value. Over half (57.30%) of food handlers showed good safety practices. Education-no education (AOR = 3.01) and primary education (AOR = 2.50), ethnicity-Madhesi/Dalit/Muslim (AOR = 2.43), awareness about food safety (AOR = 2.48), ownership of water sources (AOR = 1.88), fuel used for cooking-wood (AOR = 0.25), water facility inside the toilet (AOR = 1.94), and knowledge of food safety (AOR = 4.40) were the significant factors associated with different levels of practice. The study highlighted the importance of education, accessibility, and availability of water sources in households to minimize risks associated with foodborne diseases in Nepal.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"3233795"},"PeriodicalIF":2.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12356667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Sociodemographic, Clinical, and Lifestyle Determinants of Hypertension Among Sedentary Workers: A Cross-Sectional Study in the Cape Coast Metropolis.","authors":"Andrew Oklu, Edmund Addison, Rachel Araba Quaicoe, Addison Bouyena, Frank Naku Ghartey, Richard Armah, Nelson Ekow Kumah, Gabriel Pezahso Kotam, George Nkrumah Osei, Richard K D Ephraim","doi":"10.1155/bmri/8818300","DOIUrl":"10.1155/bmri/8818300","url":null,"abstract":"<p><p><b>Background:</b> Hypertension, a major public health concern, is a significant risk factor for a range of cardiovascular diseases and other chronic health conditions, especially in sub-Saharan Africa. This study assessed the prevalence, sociodemographic, lifestyle, and clinical determinants of hypertension among sedentary workers in the Cape Coast Metropolis. <b>Methods:</b> A cross-sectional study was conducted among 170 sedentary workers at Abura Market, Cape Coast. Sociodemographic, lifestyle, and clinical characteristics were assessed. Data was analyzed accordingly using Statistical Package for Social Sciences (SPSS) Version 26 (IBM Inco., United States). <b>Results:</b> The study involved 170 participants, of which 127 were females [median age = 42]. The prevalence of hypertension was found to be 18.2% (31/170). Increased consumption of alcohol, engagement in physical activity, fruit intake, weight, body mass index, waist circumference, hip circumference, and waist-to-hip ratio were observed among hypertensive participants compared to those without hypertension. An increased risk of hypertension incidence was found to be significantly associated with age (<i>p</i> < 0.001), having a family history of hypertension (<i>p</i> < 0.001), and experiencing shortness of breath (<i>p</i> = 0.011) in a multivariate analysis. Having a family history of hypertension and experiencing shortness of breath increase the odds of an individual developing hypertension by 23.9 and 9.49-fold. <b>Conclusion:</b> The study reveals a higher prevalence of hypertension among sedentary workers. High-risk groups for hypertension include the aged, those with a family history of hypertension, and those with diabetes mellitus. Given the lack of statistically significant symptoms, hypertension may remain undetected in individuals. The findings therefore underscore the need for public health interventions.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"8818300"},"PeriodicalIF":2.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12356678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}