BioMed Research International最新文献

{"title":"RETRACTION: The Regulation of circRNA RNF13/MiRNA-1224-5p Axis Promotes the Malignant Evolution in Acute Myeloid Leukemia.","authors":"BioMed Research International","doi":"10.1155/bmri/9814042","DOIUrl":"https://doi.org/10.1155/bmri/9814042","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2020/5654380.].</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"9814042"},"PeriodicalIF":2.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Fiber and Cancer Management: A Twenty-Five-Year Bibliometric Review of Research Trends and Directions.","authors":"Aliu Moomin, Sidique Gawusu, Abubakar Ibn Sidik, Marizuk Waris Tizumah, Maridia Kunateh Adam, Paa Kofi Tawiah Adu-Gyamfi, Kwesi Boadu Mensah","doi":"10.1155/bmri/5086946","DOIUrl":"https://doi.org/10.1155/bmri/5086946","url":null,"abstract":"<p><p><b>Background:</b> The global burden of cancer necessitates innovative approaches to its management and treatment. Traditional treatments like radiotherapy, immunotherapy, surgery, and chemotherapy, carry significant side effects that impact patient quality of life. Dietary fiber has attracted research interest as a potential mitigator of cancer progression and a supportive agent in cancer treatment. This bibliometric study analyzes trends in research connecting dietary fiber, cancer therapy, and gut health from April 1999 to May 2024. <b>Methods and Results:</b> Web of Science, PubMed, and Scopus databases were used to retrieve peer-reviewed publications from April 1999 to May 2024 on dietary fiber and cancer management. The study identifies a rising scholarly interest in dietary fiber's role in cancer management, focusing significantly on the interactions between dietary fiber and gut microbiota. These interactions are particularly noted for their influence on inflammation and cancer metastasis. The study highlights evolving research themes, the importance of specific fiber types in cancer progression, and highlights persistent foundational themes like glycosylation. Emerging areas include personalized nutrition and innovative therapeutic approaches. The geographical and institutional contributions, mainly from the United States and China, underline the significance of collaborative and interdisciplinary efforts in advancing research. <b>Conclusion:</b> This analysis emphasizes integrating dietary strategies in comprehensive cancer care and aims to address research gaps to develop more effective and patient-centered cancer therapy and prevention strategies.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"5086946"},"PeriodicalIF":2.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: KIF4A Regulates the Progression of Pancreatic Ductal Adenocarcinoma through Proliferation and Invasion.","authors":"BioMed Research International","doi":"10.1155/bmri/9759616","DOIUrl":"https://doi.org/10.1155/bmri/9759616","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2021/8249293.].</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"9759616"},"PeriodicalIF":2.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Practices, and Perceptions of the Healthcare Providers on Cervical Cancer Screening Among HIV-Positive Women at Lira Regional Referral Hospital, Lira City.","authors":"Florence Layet, Tom Murungi, Nasser Ashaba, Renniter Mirembe Nakayita, Eustes Kigongo, Marc Sam Opollo","doi":"10.1155/bmri/1156001","DOIUrl":"https://doi.org/10.1155/bmri/1156001","url":null,"abstract":"<p><p><b>Background:</b> Cervical cancer remains a global burden and is by far one of the major causes of premature death among women of reproductive age. We explored the knowledge, practices, and perceptions of healthcare providers on cervical cancer screening (CCS) among HIV-positive women aged 18-49 years in Lira City. <b>Methods:</b> In June 2023, a qualitative cross-sectional study was conducted among healthcare providers at Lira Regional Referral Hospital (LRRH), Lira City, Northern Uganda. Key informant interviews (KIIs) were used to collect data among purposively selected healthcare providers. Interviews were audio-recorded, transcribed verbatim, and coded using the NVivo (QSR International) software. Thematic content analysis was used in data analysis. <b>Results:</b> The study found that participants had good knowledge about cervical cancer and screening. They provided health education and vaccination for eligible girls and screened HIV-positive women for cervical cancer. Long waiting hours, long distances to healthcare facilities, and negative attitudes of some health providers were reported as barriers to CCS utilization. However, increased awareness, the presence of signs/symptoms, and the desire to maintain optimal health facilitated CCS utilization among HIV-positive women. <b>Conclusion:</b> Whereas the participants' knowledge and perceptions about CCS were good, their practices towards CCS among HIV-positive women were suboptimal. Continuous education of healthcare providers, decentralization of CCS, and routine and ongoing health education initiatives are pivotal in improving CCS practices among HIV-positive women.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"1156001"},"PeriodicalIF":2.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Mechanisms of Intervertebral Disc Degeneration Induced by <i>Propionibacterium acnes</i>.","authors":"Weichao Yang, Yude Xu, Yong Tan, Jinzhi Lin, Huan Chen, Shaojin Li, Haixiong Miao, Dongping Ye","doi":"10.1155/bmri/5513856","DOIUrl":"https://doi.org/10.1155/bmri/5513856","url":null,"abstract":"<p><p>Intervertebral disc degeneration (IVDD), a prevalent degenerative disorder with substantial socioeconomic impacts, is closely linked to endplate inflammation and chronic low back pain. Its pathogenesis involves multifactorial mechanisms, including long-term chronic mechanical loading, external trauma, and hereditary factors. Emerging evidence highlights <i>Propionibacterium acnes</i> (<i>P. acnes</i>), a gram-positive bacterium with potent proinflammatory properties, as a key contributor to IVDD progression. This review systematically analyses the latest literature on related studies, focusing on the molecular mechanisms of IVDD induced by <i>P. acnes</i>. Three molecules play an important role in the induction of IVDD by <i>P. acnes</i>, namely, IL-1<i>β</i>, MIF, and MMP. In addition, <i>P. acnes</i> induces IVDD through three core mechanisms, namely, proinflammatory (activation of TLR2, production of large amounts of ROS to promote inflammation), pyroptosis (production of large amounts of NLRP3 through the TXNIP-NLRP3 axis and the ROS-NLRP3 axis), and apoptosis (promotion of Bax and inhibition of Bcl-2 expression through the TLR2-JNK pathway). The dissection of these related important molecules and pathogenic mechanisms can lead to a better understanding of the role of <i>P. acnes</i> in IVDD. It can provide an important theoretical basis for future research. However, the current study's lack of large-scale clinical validation, unresolved colonization controversies, and limited experimental methods are limitations. Therefore, in the future, it is still necessary to improve the relevant theories and resolve the current controversies through more advanced experimental methods and higher quality clinical studies. In conclusion, the study of <i>P. acnes</i>-induced IVDD is promising, and further research can be conducted in the future, which is expected to develop novel therapeutic approaches for <i>P. acnes</i>, thus effectively slowing down the development of IVDD.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"5513856"},"PeriodicalIF":2.6,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation Into the Impact of Solvents on the Phytochemical Composition, Antioxidant Capacities, and Antihyperglycemic Activities of <i>Erigeron annuus</i> (L.) Pers.","authors":"Mehak Thakur, Rachna Verma, Dinesh Kumar, Manickam Sivakumar, Tabarak Malik","doi":"10.1155/bmri/6650124","DOIUrl":"https://doi.org/10.1155/bmri/6650124","url":null,"abstract":"<p><p>This study aims to assess the phytochemical composition, antioxidant potential, and antidiabetic properties of <i>Erigeron annuus</i> (L.) Pers. The ethyl acetate fraction of <i>Erigeron annuus</i> leaves exhibited the highest extraction rate (22.42%). The preliminary qualitative phytochemical analysis in crude extract and fractions is often performed using chemical tests. For quantitative analysis, spectrophotometric methods are widely used to estimate the concentration of phytochemicals. The antioxidant properties were evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and the ferric reducing antioxidant power (FRAP) assay, which measures the reduction of Fe³⁺ to Fe²⁺. Qualitative screening revealed the presence of tannins, flavonoids, phenols, saponins, and alkaloids. Notably, the ethyl acetate fraction showed significantly (<i>p</i> < 0.05) higher total phenolic content (70.01 ± 1.1 mg/g) and total flavonoid content (80.29 ± 1.03 mg/g). This fraction also demonstrated substantial <i>α</i>-amylase inhibitory activity and antioxidant potential, suggesting the ability of polyphenols to reduce <i>α</i>-amylase activity. The <i>α</i>-amylase inhibition (23.15 ± 1.22% to 67.31 ± 2.01%) activity and IC₅₀ value (40.59 ± 0.03 <i> μ</i>g/mL) were notably higher in the ethyl acetate fraction compared with the standard drug metformin (19.88 ± 1.51 <i> μ</i>g/mL). <i>Erigeron annuus</i> ethyl acetate fraction exhibited significantly higher glucose levels (10.88% ± 1.29% to 65.11 ± 0.94%) and conducted a lipid peroxidation experiment utilizing egg yolk as the source of lipids with high content. The most bioactive fraction was evaluated for cytotoxicity against the HEK293 cell line. The cytotoxicity assay revealed that 50% cell viability was observed at a concentration of 50 <i>μ</i>g/mL, indicating that the plant extract is nontoxic at concentrations below this threshold. Furthermore, the dominant fraction was further investigated using liquid chromatography-mass spectroscopy and high-performance thin-layer chromatography techniques from the selected plant. Moreover, an in vivo study will be performed to evaluate the antidiabetic efficacy of <i>Erigeron annuus</i>, isolate and characterize its bioactive components, and examine its molecular mechanism of action to improve its therapeutic applicability.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"6650124"},"PeriodicalIF":2.6,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Current Status of Frailty and Influencing Factors in Elderly Patients With Hip Fractures: A Meta-Analysis.","authors":"Kangquan Shou, Zhuoqing Wu, Zuyang Xi, Longtao Zhao, Chaxiang Li, Tongzhu Bao, Jianghua Lv, Youdan Shi","doi":"10.1155/bmri/7756605","DOIUrl":"https://doi.org/10.1155/bmri/7756605","url":null,"abstract":"<p><p><b>Background:</b> Hip fractures have emerged as a significant health risk, posing a substantial threat to the well-being and longevity of the elderly population. The occurrence of postoperative complications and frailty profoundly impacts the quality of life in these individuals. This meta-analysis is aimed at elucidating the present scenario and clarifying the current status and influencing factors of frailty in elderly hip fracture patients. The findings will serve as a solid evidence for formulating effective and scientific strategies to prevent frailty in this vulnerable patient group. <b>Methods:</b> The databases, including PubMed, Cochrane Library, and Embase, were utilized from February 2003 to February 2023, using the keywords frailty, elderly, and hip fractures to identify systematic reviews or meta-analyses. The primary randomized clinical trials included in systematic reviews or meta-analyses were identified. Two independent authors assessed the quality of all eligible studies. Statistical analyses were evaluated using Review Manager (RevMan) Version 5.3. <b>Results:</b> Of the 15 studies out of 352 identified studies, 12 cross-sectional research studies, 2 case-control studies, and 1 cohort study were confirmed. There were 3475 hip fracture patients, 1209 of them showed frailty, with a 41% incidence of frailty, and 18 influence factors were determined. A marked between-study heterogeneity (<i>I</i> ² = 95%, <i>p</i> < 0.00001) was examined. Factors influencing frailty in elderly hip fracture patients were identified including age (odds ratio (OR) = 2.73, 95% confidence interval (CI): 2.12~3.53), comorbidity (OR = 4.20, 95% CI: 2.31~7.62), duration of bed rest (OR = 2.22, 95% CI: 1.54~3.18), nutritional status (OR = 1.62, 95% CI: 1.21~2.17), and self-perceived health status (OR = 3.53, 95% CI: 2.09~5.94). There was no publication bias, and the pooled results were stable basing on sensitivity analysis. <b>Conclusion:</b> Frailty in elderly hip fracture patients is associated with a variety of factors consisting of age, comorbidity conditions, extended periods of bed rest, nutritional status, high comorbid conditions, poor self-perceived health status, advanced age, and poor nutritional status.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"7756605"},"PeriodicalIF":2.6,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dilemma and Wisdom in Translating <i>p</i> Values: A Collaborative Approach to Strengthening Scientific Validity.","authors":"Mohamad Adam Bujang","doi":"10.1155/bmri/6703756","DOIUrl":"10.1155/bmri/6703756","url":null,"abstract":"<p><p>The <i>p</i> value remains a widely used statistical tool for assessing the significance of research findings, yet its interpretation and application often provoke debate. While the <i>p</i> value provides a measure of evidence against the null hypothesis, it does not convey essential information about the strength of an effect or its statistical precision. Therefore, this paper critically examines the dilemma of translating <i>p</i> values into meaningful scientific inferences. Using illustrative examples, we demonstrate how the misapplication of <i>p</i> values can misguide policy, clinical practice, and scientific discourse. To address these challenges, this article proposes a collaborative approach involving researchers, journal reviewers, and the scholarly audience. This includes a comprehensive checklist to promote clear documentation, critical evaluation, and a more nuanced interpretation of statistical evidence. By fostering a nuanced understanding of statistical evidence, this initiative seeks to advance scientific validity and ensure that research findings contribute meaningfully to societal progress.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"6703756"},"PeriodicalIF":2.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11976038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of DNA Methylation in the Pathogenesis of Skin Disorders: Mechanisms, Inhibitors of Methylation-Related Enzyme, and Molecular Docking Studies.","authors":"Anchal Rani, Gagandeep Kaur, Ravinder Kumar, Rohan Samir Kumar Sachan, Mukesh Kumar, Harsh Sable, Abdel Rahman Mohammad Al Tawaha, Shahid Malik, Arun Karnwal, Tabarak Malik","doi":"10.1155/bmri/7002918","DOIUrl":"10.1155/bmri/7002918","url":null,"abstract":"<p><p>DNA methylation is an epigenetic mechanism modulating gene expression without altering the genetic sequence and plays a significant role in skin disorders. Methylation patterns on specific genes can lead to either overexpression or suppression, impacting cellular functions critical to skin health. Skin disorders such as atopic dermatitis, eczema, androgenetic alopecia, systemic lupus erythematosus, psoriasis, and systemic sclerosis have been linked to abnormal DNA methylation, which contributes to disease progression through immune dysregulation, barrier dysfunction, and inflammation. The methylation of genes like S100A2 and FCERIG in atopic dermatitis or FLG in eczema illustrates how modifications affect immune pathways and skin integrity. Recent advancements in DNA methylation analysis have enhanced the precision of detecting methylation levels and their influence on gene expression, leading to a deeper understanding of disease mechanisms. Identifying aberrant methylation patterns offers potential biomarkers for early diagnosis and therapeutic targets, especially in autoimmune and inflammatory skin diseases. Further exploration of epigenetic changes could pave the way for innovative treatments, addressing underlying epigenetic disruptions that characterize these conditions.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"7002918"},"PeriodicalIF":2.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythroferrone-Driven Regulation of Hepcidin and Iron Levels in Polytransfused Sickle Cell Anaemia Patients: A Prospective Study.","authors":"Samuel Kwasi Appiah, Charles Nkansah, Godfred Amoah Appiah, Gabriel Abbam, Felix Osei-Boakye, Samira Daud, Kofi Mensah, Safo Adwoa, Korah Seedolf Kuwaahsuore, Emmanuel Yeboah, Abu Siraj Salma Tiyumba, Dennis Thompson, Viel Mary Paula, Louis Adda Duibajia, Peter Takyia, Franklina Ataa Kwarteng, Obed Odame Asiedu, Firdaus Ibrahim Sukasorr, Vincent Kawuribi, Boniface Nwofoke Ukwah, Ejike Felix Chukwurah","doi":"10.1155/bmri/6803051","DOIUrl":"10.1155/bmri/6803051","url":null,"abstract":"<p><p>The interplay of erythroferrone (ERFE), hepcidin, and ferroportin is crucial for ensuring systemic iron homeostasis. This study determined the influence of ERFE on hepcidin and iron levels in polytransfused patients with sickle cell anaemia (SCA). This multicentre case-control study recruited 60 SCA participants and 30 controls (HbA), aged 2-34 years, from Tamale Teaching Hospital; Methodist Hospital, Wenchi; and Seventh Day Adventist Hospital, Sunyani, Ghana, between the periods of March to July 2023. About 4 mL of blood was collected for a full blood count using a haematology analyzer and serum ERFE, hepcidin, ferroportin, and ferritin estimation using an enzyme-linked immunosorbent assay. Data were analyzed using SPSS Version 26.0. ERFE (<i>p</i> < 0.001), ferroportin (<i>p</i> = 0.016), ferritin (<i>p</i> < 0.001), serum iron (<i>p</i> < 0.001), transferrin (<i>p</i> = 0.001), soluble transferrin receptor (sTFR) (<i>p</i> = 0.019), TWBC (<i>p</i> < 0.001), and platelet (<i>p</i> < 0.001) were significantly higher in SCA participants and hydroxyurea-naïve participants than in the control group and hydroxyurea-treated participants, respectively. Levels of hepcidin (<i>p</i> < 0.001), red blood cell (<i>p</i> < 0.001), haemoglobin (<i>p</i> < 0.001), and haematocrit (<i>p</i> < 0.001) were lower in the SCA and hydroxyurea-naïve groups than in the control and hydroxyurea-treated groups, respectively. An inverse correlation was observed between serum ERFE and hepcidin (<i>r</i> = -0.391, <i>p</i> = 0.002) and hepcidin and ferroportin (<i>r</i> = -0.266, <i>p</i> = 0.040), while ferritin (<i>r</i> = 0.439, <i>p</i> < 0.001) and ferroportin (<i>r</i> = 0.309, <i>p</i> = 0.016) showed a positive correlation with ERFE. No correlation was found between serum hepcidin and ferritin levels (<i>r</i> = 0.025, <i>p</i> = 0.853). Again, participants with regular blood transfusions had significantly higher levels of ERFE (<i>p</i> < 0.001) and ferritin (<i>p</i> = 0.002) than those with rare and no transfusions per year. None of the SCA participants had done iron testing. In conclusion, the negative impact of ERFE on hepcidin levels may exacerbate the risk of iron burden, as evident by elevated iron levels in SCA patients and the need for regular monitoring of the iron status of polytransfused SCA patients.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2025 ","pages":"6803051"},"PeriodicalIF":2.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11964725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}