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Mental Health Consequences of the COVID-19 Outbreak Among Emergency Department Healthcare Workers. COVID-19 在急诊科医护人员中爆发的心理健康后果。
3区 生物学
BioMed Research International Pub Date : 2024-09-09 DOI: 10.1155/2024/8871959
Marion Douplat,Fabien Subtil,Anne Termoz,Laurent Jacquin,Frédéric Verbois,Veronique Potinet,Romain Hernu,Verena Landel,Stéphanie Mazza,Julien Berthiller,Julie Haesebaert,Karim Tazarourte
{"title":"Mental Health Consequences of the COVID-19 Outbreak Among Emergency Department Healthcare Workers.","authors":"Marion Douplat,Fabien Subtil,Anne Termoz,Laurent Jacquin,Frédéric Verbois,Veronique Potinet,Romain Hernu,Verena Landel,Stéphanie Mazza,Julien Berthiller,Julie Haesebaert,Karim Tazarourte","doi":"10.1155/2024/8871959","DOIUrl":"https://doi.org/10.1155/2024/8871959","url":null,"abstract":"Study Objective: The present study is aimed at providing an assessment of the changes in burnout, job strain, isostrain, sleepiness, and fatigue levels over time and identifying factors associated with these symptoms among healthcare workers in French emergency departments (EDs). Method: We conducted a prospective, multicenter study in four EDs and an emergency medical service. Participants completed questionnaires at inclusion and at 90 days to assess burnout, job strain, isostrain, sleepiness, and fatigue. Results: A total of 211 respondents (43.5%) completed the questionnaires at inclusion. At the beginning of the study, 84 (40.8%) participants presented symptoms of burnout, 86 (43.2%) had symptoms of job strain, and 58 (29.4%) of isostrain. Forty-two (20.1%) healthcare workers presented symptoms of sleepiness, and 8 (3.8%) had symptoms of fatigue. We found that symptoms of burnout were more frequent for healthcare workers with a previous psychiatric history (55.3% vs. 39.1%, p = 0.02) and were lower among participants who had at least one dependent child (33.1% vs. 48.3%, p = 0.013). Symptoms of job strain were higher among administrative staff compared to physicians (55.6% vs. 28.7%, p = 0.01) and among healthcare workers with managerial responsibilities compared to those without (45.6% vs. 28.8%, p = 0.015). Symptoms of isostrain were higher among administrative staff (42.3%) compared to paramedics (34.1%) and physicians (19.8%, p = 0.026). Conclusion: We identified that potential factors associated with the emergence of symptoms of burnout and job strain are suggested, underlining several areas of improvement for the prevention against mental health disorders in the specific population of ED healthcare workers. Trial Registration: ClinicalTrials.gov identifier: NCT04383886.","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"41 1","pages":"8871959"},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concurrent Eosinophilia Increases the Prevalence of Nail Abnormalities and Severity of Hair Loss in Patients With Alopecia Areata. 嗜酸性粒细胞增多会增加脱发症患者指甲异常的发生率和脱发的严重程度
3区 生物学
BioMed Research International Pub Date : 2024-09-07 DOI: 10.1155/2024/5596647
Giovanni Damiani,Laura Cristina Gironi,Rosalynn R Z Conic,Massimo Del Fabbro,Paola Savoia,Marco Fiore,Wilma F Bergfeld
{"title":"Concurrent Eosinophilia Increases the Prevalence of Nail Abnormalities and Severity of Hair Loss in Patients With Alopecia Areata.","authors":"Giovanni Damiani,Laura Cristina Gironi,Rosalynn R Z Conic,Massimo Del Fabbro,Paola Savoia,Marco Fiore,Wilma F Bergfeld","doi":"10.1155/2024/5596647","DOIUrl":"https://doi.org/10.1155/2024/5596647","url":null,"abstract":"Background: The potential link between alopecia areata (AA) and eosinophilia is unclear, as well as its clinical manifestations in these patients' subsets. Methods: This is a monocentric retrospective observational study in which clinical and laboratory data were summarized and evaluated the AA subset with concurrent eosinophilia. Results: In a sample of 205 AA patients, 38 (18.5%) were classified as AA with eosinophilia. Interestingly, this subset of patients had a statistically higher prevalence of atopia and nail abnormalities (p < 0.05) than AA without eosinophilia. AA patients with eosinophilia had a 3.70 higher odds of more severe hair loss versus age- and gender-matched AA without eosinophilia. Conclusions: AA patients with eosinophilia had distinctive clinical and laboratory characteristics, so future studies may potentially explore the use of IL-5 inhibitors.","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"17 1","pages":"5596647"},"PeriodicalIF":0.0,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immediate and Long-Term Pull-Out Bond Strength of 3D-Printed Provisional Crowns. 三维打印临时冠的即刻和长期拔出粘接强度。
3区 生物学
BioMed Research International Pub Date : 2024-09-04 DOI: 10.1155/2024/7205011
Joyce R C Dos S Siqueira,Rita M M Rodriguez,Nathalia de C Ramos,Marco A Bottino,João P M Tribst
{"title":"Immediate and Long-Term Pull-Out Bond Strength of 3D-Printed Provisional Crowns.","authors":"Joyce R C Dos S Siqueira,Rita M M Rodriguez,Nathalia de C Ramos,Marco A Bottino,João P M Tribst","doi":"10.1155/2024/7205011","DOIUrl":"https://doi.org/10.1155/2024/7205011","url":null,"abstract":"Background: Over the past decade, 3D printing technology has revolutionized various fields, including dentistry. Provisional restorations play a crucial role in prosthetic rehabilitation, necessitating the evaluation of their bond strength with different provisional cement agents. Aims: This study is aimed at assessing the immediate and long-term bond strength of 3D-printed dental crowns using three provisional cement agents. Materials and Methods: Provisional crowns (N = 36) were manufactured using 3D modeling software and cemented in dentin analogues (G10 Nema resin). After the crowns' fabrication, they were randomly divided into three groups (n = 12) for cementation with Relyx Temp 3M ESPE, Provicol-VOCO, and Meron-VOCO. Tensile strength tests were conducted using a universal testing machine, with half of the specimens subjected to 2000 thermal cycles before testing. Finite element analysis was employed to assess tensile stress distribution. Results: Statistical analysis (two-way ANOVA and Tukey's test at a 95% confidence level) revealed significant effects of cement type (p = 0.006) and thermal aging (p = 0.001) on bond strength. Glass ionomer cement exhibited the highest immediate resistance, while all types of cement were adversely affected by thermal aging, resulting in decreased bond strength. Conclusion: Thermal aging significantly alters the properties of 3D printing resin and affects the bond strength of provisional cement with 3D-printed crowns. Despite the adverse effects of thermal aging, glass ionomer cement demonstrated the highest immediate resistance. Clinicians should carefully consider these findings when selecting provisional cements for 3D-printed crowns.","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"23 1","pages":"7205011"},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142186862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optical Surface Management System and BladderScan for Patient Setup During Radiotherapy of Postoperative Prostate Cancer. 用于前列腺癌术后放疗期间患者设置的光学表面管理系统和膀胱扫描系统
3区 生物学
BioMed Research International Pub Date : 2024-09-04 DOI: 10.1155/2024/3573796
Hao Chen,Yandong Liu,Songbin Qin,Guanghui Gan
{"title":"Optical Surface Management System and BladderScan for Patient Setup During Radiotherapy of Postoperative Prostate Cancer.","authors":"Hao Chen,Yandong Liu,Songbin Qin,Guanghui Gan","doi":"10.1155/2024/3573796","DOIUrl":"https://doi.org/10.1155/2024/3573796","url":null,"abstract":"Background: The precision of postoperative prostate cancer radiotherapy is significantly influenced by setup errors and alterations in bladder morphology. Utilizing daily cone beam computed tomography (CBCT) imaging allows for the correction of setup errors. However, this naturally leads to the question of the issue of peripheral dose and workload. Thus, a zero-dose, noninvasive technique to reproduce the bladder volume and improve patient setup accuracy was needed. Purpose: The aim of this study is to investigate if the setup method by combining Optical Surface Management System (OSMS) and BladderScan can improve the accuracy of setup and accurately reproduce the bladder volume during radiotherapy of postoperative prostate cancer and to guide CTV-PTV margins for clinic. Method: The experimental group consisted of 15 postoperative prostate cancer patients who utilized a setup method that combined OSMS and BladderScan. This group recorded 103 setup errors, verified by CBCT. The control group comprised 25 patients, among whom 114 setup errors were recorded using the conventional setup method involving skin markers; additionally, patients in this group also exhibited spontaneous urinary suppression. The errors including lateral (Lat), longitudinal (Lng), vertical directions (Vrt), Pitch, Yaw, and Roll were analyzed between the two methods. The Dice similarity coefficient (DSC) and volume differences of the bladder between CBCT and planning CT were compared as the bladder concordance indicators. Results: The errors in the experimental group at Vrt, Lat, and Lng were 0.17 ± 0.12, 0.22 ± 0.17, and 0.18 ± 0.12 cm, and the control group were 0.25 ± 0.15, 0.31 ± 0.21, 0.34 ± 0.22 cm. The rotation errors of Pitch, Roll, and Yaw in the experimental group were 0.18 ± 0.12°, 0.11 ± 0.1°, and 0.18 ± 0.13°, and in the control group, they were 0.96 ± 0.89°, 1.01 ± 0.86°, and 1.02 ± 0.84°. The DSC and volume differences were 92.52 ± 1.65% and 39.99 ± 28.75 cm3 in the patients with BladderScan, and in the control group, they were 62.98 ± 22.33%, 273.89 ± 190.62 cm3. The P < 0.01 of the above performance indicators indicates that the difference is statistically significant. Conclusion: The accuracy of the setup method by combining OSMS and BladderScan was validated by CBCT in our study. The method in our study can improve the setup accuracy during radiotherapy of postoperative prostate cancer compared to the conventional setup method.","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"37 1","pages":"3573796"},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142186863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computed Tomography Findings of Patients Presenting With Headache: 4-Year Retrospective Two-Center Study in Central and Western Regions of Ghana. 头痛患者的计算机断层扫描结果:加纳中部和西部地区双中心 4 年回顾性研究》。
IF 2.6 3区 生物学
BioMed Research International Pub Date : 2024-09-02 eCollection Date: 2024-01-01 DOI: 10.1155/2024/1833140
Bashiru Babatunde Jimah, Benjamin Dabo Sarkodie, Asare Kwaku Offei, Ewurama Andam Idun, Dorothea Anim, Edmund Brakohiapa, Benard Ohene Botwe
{"title":"Computed Tomography Findings of Patients Presenting With Headache: 4-Year Retrospective Two-Center Study in Central and Western Regions of Ghana.","authors":"Bashiru Babatunde Jimah, Benjamin Dabo Sarkodie, Asare Kwaku Offei, Ewurama Andam Idun, Dorothea Anim, Edmund Brakohiapa, Benard Ohene Botwe","doi":"10.1155/2024/1833140","DOIUrl":"10.1155/2024/1833140","url":null,"abstract":"<p><p><b>Objectives:</b> The radiographic assessment of the head is a crucial part of headache care. A computed tomography (CT) scan enables a more detailed analysis of the condition and more focused care. This study examined head CT scans to determine what kinds of anomalies were present in patients with headaches as their primary complaint. <b>Methods:</b> We evaluated 4 years' worth of CT scan data from head exams conducted at two diagnostic facilities in Ghana's western and central regions. We examined data on 477 patients with a headache as their primary complaint between January 2017 and December 2020. We employed chi-square and Fisher's exact tests (where applicable) to compare head CT diagnoses between age groups, gender, headache subtypes, and brain lesion subgroups. <b>Results:</b> There were 53.5% (<i>n</i> = 255) females and 46.5% (<i>n</i> = 222) males in the study. The average age of patients was 38.67 ± 17.23 years, with an annual rate of abnormal CT diagnoses ranging from 35.9% in 2017 to 45.4% in 2022. Abnormal head CT diagnoses are strongly correlated with age groups and patient gender (<i>p</i> = 0.011 and <i>p</i> = 0.009, respectively). Of the 202 patients, 15.3% and 24.3% were classified as intracranial lesions and extracranial lesions, respectively. Maxillary sinusitis affected nearly 60% of the patients, while tumors and hemorrhages affected 25.2% and 11.9%, respectively. <b>Conclusions:</b> A CT scan of the head is essential to detect abnormalities in nearly 50% of patients suffering from various degrees of headache. Sinusitis, brain tumors, and hemorrhage were common lesions detected. It is crucial to create local standard operating procedures to promote better utilization of this type of imaging service, particularly among patients who have been diagnosed with headaches.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"1833140"},"PeriodicalIF":2.6,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11383647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Spontaneously Reported Adverse Drug Events: Towards Developing Systems for Preventability. 分析自发报告的药品不良事件:开发可预防性系统。
IF 2.6 3区 生物学
BioMed Research International Pub Date : 2024-08-30 eCollection Date: 2024-01-01 DOI: 10.1155/2024/1906797
Courage Edem Ketor, Charles Kwaku Benneh, Emmanuel Sarkodie, Juliet Ama Anaglo, Adelaide Mensah, Samuel Owusu Somuah, Selorm Akakpo, Eric Woode
{"title":"Analysis of Spontaneously Reported Adverse Drug Events: Towards Developing Systems for Preventability.","authors":"Courage Edem Ketor, Charles Kwaku Benneh, Emmanuel Sarkodie, Juliet Ama Anaglo, Adelaide Mensah, Samuel Owusu Somuah, Selorm Akakpo, Eric Woode","doi":"10.1155/2024/1906797","DOIUrl":"10.1155/2024/1906797","url":null,"abstract":"<p><p><b>Background:</b> Analysing data on adverse drug reactions (ADRs) in health facilities is an essential step to help develop effective strategies to reduce their incidence. The objective was to analyse spontaneous ADR reports sent to the Ghanaian Food and Drugs Authority (FDA) by two reporting health facilities over 5 years. <b>Methods:</b> Data from duplicate spontaneous ADR reports sent to the FDA (Ghana) from 2014 to 2018 were extracted. The relationship between independent variables such as age, sex, and source of drugs and ADR outcomes was assessed with either chi-square or a Cramer's V test for association where appropriate. <b>Results:</b> Type A reactions (65.2%) were the most prevalent of the ADRs, followed by Type B (34.1%), with the majority (80%) of patients affected recovering fully. The majority of Type A reactions (54.1%) occurred in the clinic, while the majority of Type B reactions (43.5%) occurred in the hospital. The skin and central nervous system (CNS) were the most affected (70.8%) organs. A higher incidence of CNS and skin-related ADRs was recorded in patients older than 30 (RR = 1.28 (1.07-1.53)). Also, females were more likely to experience a CNS-related ADR. The seriousness of the ADR was found to be significantly associated with the (1) type of prescriber, (2) whether the drug was prescribed, or (3) whether the drug regimen prescribed was appropriate. Even though, in 86% of cases, the offending drug was withdrawn within the first 5 days, it exceeded 20 days in about 6% of cases. The record of allergy status in a patient's folder and the source of the drug were significantly associated with the chance that the offending drug was withdrawn. However, recording ADRs did not influence whether the offending drug was stopped. <b>Conclusion:</b> Most of the ADRs experienced by patients could be avoided if the current systems are improved to prevent the rechallenge of offending drugs. Efforts to improve and update patient medication records and steps to ensure continuity of care are essential in preventing these adverse drug events.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"1906797"},"PeriodicalIF":2.6,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11379512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Finite Element Assessment of a Novel Patient-Specific Mandibular Implant for Severely Atrophic Ridge. 针对严重萎缩牙槽骨的新型下颌骨植入体的有限元评估
IF 2.6 3区 生物学
BioMed Research International Pub Date : 2024-08-29 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9735427
Alireza Parhiz, Reza Nourishirazi, Amirali Asadi, Morad Karimpour
{"title":"Finite Element Assessment of a Novel Patient-Specific Mandibular Implant for Severely Atrophic Ridge.","authors":"Alireza Parhiz, Reza Nourishirazi, Amirali Asadi, Morad Karimpour","doi":"10.1155/2024/9735427","DOIUrl":"10.1155/2024/9735427","url":null,"abstract":"<p><p><b>Purpose:</b> Dental reconstruction for patients diagnosed with severe mandibular bone atrophy using common dental implants is a challenging process. In such cases, surgeons may encounter challenges such as insufficient available bone, soft tissue, damage to the inferior alveolar nerve, and even the risk of bone fracture. In this study, a new design concept of mandibular patient-specific implants for severely atrophic ridges followed by finite element evaluation was presented to investigate the mechanical functionality of the concept. <b>Method:</b> The implant is comprised of two modular parts including an inferior border cover and a horseshoe-shaped structure. This horseshoe segment fits into the cover and is then screwed to it using two screws on each side. A 1 mm deflection was applied to a reference point located between the two anterior posts to extract the resulting Von Mises stress distribution in each part and the reaction force on the reference point which corresponds to the chewing force that the patient must apply to deform the horseshoe. This 1 mm gap is a design consideration and critical distance that horseshoe contacts the gingiva and disturbs the alveolar nerve. <b>Results:</b> The results revealed that load was transmitted from the horseshoe to the cover, and there were no stress contours on the body of the mandible. However, stress concentration was observed in screw locations in the mandible, the amount of which was decreased by increasing the number of used screws. In horseshoe, stress concentration values were around 350 MPa, and the measured reaction force on the reference point was just under 200 N. <b>Conclusion:</b> The finite element analysis results showed that this concept would be functional as the minimum load would be transmitted to the mandibular ridge, and since the patients diagnosed with atrophic ridge are not able to apply load to an amount near 200 N, the horseshoe would not contact the gingiva. Also, it is concluded that increasing the number of bone screw fixations would decrease the risk of long-term screw loosening.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"9735427"},"PeriodicalIF":2.6,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Etiologic Profile of the Pneumococcus in Ghana: A Systematic Review. 加纳肺炎球菌的病因概况:系统回顾。
IF 2.6 3区 生物学
BioMed Research International Pub Date : 2024-08-27 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8368996
Reuben E Arhin, Eric S Donkor, Hans-Christian Slotved, Fleischer C N Kotey, Nicholas T K D Dayie
{"title":"Etiologic Profile of the Pneumococcus in Ghana: A Systematic Review.","authors":"Reuben E Arhin, Eric S Donkor, Hans-Christian Slotved, Fleischer C N Kotey, Nicholas T K D Dayie","doi":"10.1155/2024/8368996","DOIUrl":"10.1155/2024/8368996","url":null,"abstract":"<p><p><b>Objective:</b> To describe the profile of <i>Streptococcus pneumoniae</i>, identify research gaps, and provide in-depth insights into various aspects related to the pathogen. <b>Methods:</b> Google Scholar, PubMed, and ScienceDirect were searched for all studies on the pneumococcus in Ghana that reported on specimen collected, population and sample size, carriage prevalence, incidence of pneumococcal diseases, age of the study population, types of test performed, serotypes identified, antimicrobial susceptibilities, or molecular analysis on the pneumococci for data extraction. <b>Results:</b> Overall, a total of 7954 results were obtained from the three-database search, and of this, 24 articles were selected after screening. A total of 924 isolates were accounted for by serotyping/serogrouping. The prevalence of pneumococcal carriage in Ghana ranges from 11.0% to 51.4% in the population depending on the age (≤ 24-80 years), sickle cell disease (SCD), human immunodeficiency virus (HIV) status, or health of the study population, and penicillin (Pen)-nonsusceptible isolates ranged from 17% to 63%. The prevalence of pneumococci found as the etiologic agent of diseases among Ghanaians ranges from 3.4% for otitis media to 77.7% for meningitis. Overall, the 13-valent pneumococcal conjugate vaccine (PCV) (PCV-13) carriage serotypes accounted for 28.4% of the reported pneumococcal isolates. PCV-13 invasive serotypes accounted for 22.4% of the reported isolates. The non-PCV-13 carriage serotypes accounted for most (43.9%) of the reported isolates. In the pre-PCV-13 era, the nontypeable (NT) (5.5%) and other nonvaccine types (NVTs) (6.4%) were reported as being predominant. The non-PCV-13 serotypes accounted for 4.4% of the reported isolates in invasive pneumococcal disease (IPD) cases. Multidrug resistance (MDR) ranged from 7.8% to 100%. <b>Conclusion:</b> Predicting the invasiveness of pneumococci using molecular typing is the way to go in the future as this will provide answers to the extent to which capsular switching is contributing to the pneumococcal disease burden in Ghana almost a decade after introducing PCV-13. Continuous monitoring of antibiotic resistance patterns at both phenotypic and genotypic levels, along with serotyping and molecular typing, should be a standard practice in the surveillance of pneumococcal disease burden in Ghana.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"8368996"},"PeriodicalIF":2.6,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11371446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142124758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring Zirconia Adhesion: Pre and Postsintering Physical Surface Treatment, Chemical Treatment, and Cement Interactions. 探索氧化锆的附着力:烧结前和烧结后的物理表面处理、化学处理和水泥相互作用。
IF 2.6 3区 生物学
BioMed Research International Pub Date : 2024-08-22 eCollection Date: 2024-01-01 DOI: 10.1155/2024/5394652
Flávia Gonçalves, Mirko Dennys Ayala-Perez, Francisco Carlos Dos Santos Reis, Walter Gomes Miranda-Júnior, Letícia Cristina Cidreira Boaro
{"title":"Exploring Zirconia Adhesion: Pre and Postsintering Physical Surface Treatment, Chemical Treatment, and Cement Interactions.","authors":"Flávia Gonçalves, Mirko Dennys Ayala-Perez, Francisco Carlos Dos Santos Reis, Walter Gomes Miranda-Júnior, Letícia Cristina Cidreira Boaro","doi":"10.1155/2024/5394652","DOIUrl":"10.1155/2024/5394652","url":null,"abstract":"<p><p><b>Background:</b> Adhesion to zirconia remains a significant dental challenge. This study is aimed at assessing the bond strength of zirconia based on surface treatment with pre or postsintering sandblasting associated with different chemical treatments and resin cements. <b>Methods:</b> Zirconia blocks were divided into 12 experimental groups based on the surface treatment (presintering sandblasting or postsintering sandblasting/tribochemical abrasion treatment), chemical treatment (none, Single Bond Universal, or Signum Zirconia Bond), and choice of cement (Panavia F or RelyX™ U200). The bond strength was measured by shear tests using a universal testing machine. The fracture analysis was performed using stereomicroscopy. Data were analyzed using three-way ANOVA and Tukey's test (<i>α</i> = 5%). <b>Results:</b> Triple and double factor's interactions were not significant (<i>p</i> > 0.05). Regarding the surface treatment factor, the bond strength following postsintering sandblasting treatment associated with tribochemical abrasion (9.15 ± 3.62 MPa) was significantly higher than presintering sandblasting treatment (5.24 ± 3.53 MPa). Concerning the chemical treatment factor, bond strengths were ranked as follows: Signum Zirconia Bond > Single Bond Universal > no treatment. The bond strength of the resin cements did not differ among them. Most fractures (67%) were classified as adhesive, and 32% were categorized as mixed fractures. <b>Conclusion:</b> Surface treatment via postsintering sandblasting combined with tribochemical abrasion demonstrated superior efficacy than in presintering sandblasting. Additionally, chemical treatment with zirconia primer increased the bond strength of zirconia irrespective of the surface physical treatment.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"5394652"},"PeriodicalIF":2.6,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11362578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the Therapeutic Potential of Systemic Ozone on Skin Wound Repair: Clinical, Histological, and Immunohistochemical Study in Rats. 揭示全身臭氧对皮肤伤口修复的治疗潜力:大鼠临床、组织学和免疫组织化学研究。
IF 2.6 3区 生物学
BioMed Research International Pub Date : 2024-08-20 eCollection Date: 2024-01-01 DOI: 10.1155/2024/6623114
Jânderson de Medeiros Cardoso, Edilson Ervolino, Erton Massamitsu Miyasawa, Leticia Helena Theodoro, Luis Eduardo Marques Padovan, Estevão Lopes Pereira, Rafael Scaf de Molon, Valdir Gouveia Garcia
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