BioMed Research International最新文献

{"title":"Molecular Detection of Tick-Borne Pathogens in Kumasi: With a First Report of Zoonotic Pathogens in Abattoir Workers.","authors":"Seth Offei Addo, Stacy Amoah, Nancy Martekai Unicorn, Emmanuella Tiwaa Kyeremateng, Genevieve Desewu, Patrick Kwasi Obuam, Richard Odoi-Teye Malm, Emmanuel Osei-Frempong, Francisca Adai Torto, Stephen Kwabena Accorlor, Philip Kweku Baidoo, Samuel K Dadzie, John Asiedu Larbi","doi":"10.1155/2024/4848451","DOIUrl":"10.1155/2024/4848451","url":null,"abstract":"<p><p>Tick-borne pathogens continue to infect humans and animals worldwide. By adapting to the movement of livestock, ticks facilitate the spread of these infectious pathogens. Humans in close contact with animals that could be amplifying hosts are especially at risk of being infected with tick-borne pathogens. This study involved the collection of dry blood spots (DBSs) to determine tick-borne pathogens occurring in slaughtered livestock and abattoir workers in Kumasi. This study employed the use of conventional PCR, RT-PCR, and Sanger sequencing to detect and identify the tick-borne pathogens. The resulting data was analysed using Stata version 13. A total of 175 DBSs were collected from goats (76), cattle (54), and sheep (45) in the Kumasi abattoir (130, 74.29%) and Akwatia Line slaughter slab (45, 25.71%). The pathogens identified were mostly bacterial including <i>Anaplasma capra</i> (9.71%), <i>Anaplasma phagocytophilum</i> (1.14%), and <i>Rickettsia aeschlimannii</i> (0.57.%). The only parasite identified was <i>Theileria ovis</i> (9.14%). A significant association was seen between <i>A. capra</i> (<i>p</i> < 0.001) infection and female sheep sampled from the Akwatia Line slaughter slab. Again, there was a significant association between <i>T. ovis</i> (<i>p</i> < 0.001) infections and female sheep from the Kumasi abattoir. From the human DBS (63) screened, the pathogens identified were all bacterial including <i>Coxiella burnetii</i> (1.89%), <i>Rickettsia africae</i> (1.89%), and <i>R. aeschlimannii</i> (1.89%). This study reports the first detection of <i>R. aeschlimannii</i> in livestock as well as the occurrence of the above-mentioned pathogens in humans in Ghana. Animals can serve as amplifying hosts for infectious pathogens; hence, there is an increased risk of infections among the abattoir workers. Continuous surveillance effort is essential, and abattoir workers need to protect themselves from tick bites and infectious tick-borne pathogens.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"4848451"},"PeriodicalIF":2.6,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11260511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole Exome Sequencing in Vaccine-Induced Thrombotic Thrombocytopenia (VITT).","authors":"Betti Giusti, Elena Sticchi, Tommaso Capezzuoli, Rebecca Orsi, Lapo Squillantini, Marco Giannini, Samuele Suraci, Angela Antonietta Rogolino, Francesca Cesari, Martina Berteotti, Anna Maria Gori, Elena Lotti, Rossella Marcucci","doi":"10.1155/2024/2860547","DOIUrl":"10.1155/2024/2860547","url":null,"abstract":"<p><p><b>Background:</b> In February 2021, a few cases of unusual, severe thrombotic events associated with thrombocytopenia reported after vaccination with ChAdOx1 nCoV-19 (Vaxzevria) or with Johnson & Johnson's Janssen vaccine raise concern about safety. The vaccine-induced thrombotic thrombocytopenia (VITT) has been related to the presence of platelet-activating antibodies directed against platelet Factor 4. <b>Objectives:</b> We investigated VITT subject genetic background by a high-throughput whole exome sequencing (WES) approach in order to investigate VITT genetic predisposition. <b>Methods:</b> Six consecutive patients (females of Caucasian origin with a mean age of 64 years) were referred to the Atherothrombotic Diseases Center (Department of Experimental and Clinical Medicine, Azienda Ospedaliero-Universitaria Careggi, Florence) with a diagnosis of definite VITT underwent WES analysis. WES analysis was performed on the Illumina NextSeq500 platform. <b>Results:</b>WES analysis revealed a total of 140,563 genetic variants. Due to VITT's rare occurrence, we focused attention on rare variants. The global analysis of all high-quality rare variants did not reveal a significant enrichment of mutated genes in biological/functional pathways common to patients analyzed. Afterwards, we focused on rare variants in genes associated with blood coagulation and fibrinolysis, platelet activation and aggregation, integrin-mediated signaling pathway, and inflammation with particular attention to those involved in vascular damage, as well as autoimmune thrombocytopenia. According to ACMG criteria, 47/194 (24.2%) rare variants were classified as uncertain significance variants (VUS), whereas the remaining were likely benign/benign. <b>Conclusion:</b> WES analysis identifies rare variants possibly favoring the prothrombotic state triggered by the exposure to the vaccine. Functional studies and/or extensions to a larger number of patients might allow a more comprehensive definition of these molecular pathways.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"2860547"},"PeriodicalIF":2.6,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11260508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare Professionals' Attitude to Using Mobile Health Technology and Its Associated Factors in a Resource-Limited Country-An Implication for Digital Health Implementers: A Cross Sectional Study.","authors":"Agmasie Damtew Walle, Fikadu Wake Butta, Sisay Yitayih Kassie, Alex Ayenew Chereka, Shuma Gosha Kanfe, Abiy Tasew Dubale, Ermias Bekele Enyew, Geleta Nenko Dube, Adamu Ambachew Shibabaw, Mekonnen Kenate Hunde, Gemeda Wakgari Kitil, Tigist Andargie Ferede, Sisay Maru Wubante, Nebebe Demis Baykemagn, Addisalem Workie Demsash","doi":"10.1155/2024/1631376","DOIUrl":"10.1155/2024/1631376","url":null,"abstract":"<p><p><b>Background:</b> Mobile health has become widely used within the healthcare system, and there is an increasing worldwide trend toward employing this innovation for behavior management, disease monitoring, the control and prevention of various health issues, and rising enrollment in healthcare services. Although mHealth is becoming more widely available, there is no evidence about the attitude of healthcare professionals toward mHealth in southwest Ethiopia. Therefore, this study is aimed at assessing the attitude of healthcare professionals to using mHealth technology and associated factors in Ethiopia. <b>Methods:</b> An institutional cross-sectional study was conducted among 422 healthcare professionals. Data were collected using a pretested interviewer-administered questionnaire, and the study was conducted from January 08 to February 10, 2023. EpiData Version 4.6 for entering the data and STATA Version 14 for analyzing the data were used. A multivariable logistic regression analysis was carried out to identify factors associated with healthcare professionals' attitudes to using mobile health technology. <b>Results:</b> A total of 415 study participants were included in the study. About 180 (43.4%) respondents had a favorable attitude toward mHealth technology in southwest public hospitals. Master's degree and above (adjusted odds ratio [AOR]: 3.67; 95% CI: 1.22, 4.10), good knowledge of mobile health technology (AOR: 4.08; 95% CI: 1.35, 5.31), more than 5 years of work experience (AOR: 3.09; 95% CI: 1.76, 5.60), had ICT infrastructure (AOR: 2.70; 95% CI: 1.38, 5.31), had own smart mobile (AOR: 3.67; 95% CI: 3.20, 4.31), and had taken computer-related training (AOR: 1.96; 95% CI: 1.03, 3.73) were positively associated with healthcare professionals' attitude to using mobile health technologies in southwest Ethiopia. <b>Conclusions:</b> Overall, healthcare professionals' attitude to using mobile health technologies in southwest Ethiopia was relatively low. Education level, good knowledge, years of work experience, ICT infrastructure, having a smart mobile, and having taken computer-related training were significant factors of attitude to using mobile health technologies. Considering these factors could provide insight into developing and adopting mobile health technologies in Ethiopia.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"1631376"},"PeriodicalIF":2.6,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11259502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of Low Birth Weight Among Newborns Delivered at Public Health Facilities of Bishoftu Town, East Shewa Zone, Ethiopia: Unmatched Case-Control Study.","authors":"Daniel Bekele, Balay Dhaba, Abenet Menene, Leta Hinkosa","doi":"10.1155/2024/4873667","DOIUrl":"10.1155/2024/4873667","url":null,"abstract":"<p><p><b>Background:</b> Low birth weight (LBW) is a major global public health issue that can have a number of serious, potentially fatal health consequences. It is the most common cause of neonatal and child death in low- and middle-income countries, which also has a number of negative health effects. However, the determinants of LBWs were not yet completely recognized in Ethiopia. Thus, it is aimed at identifying the determinants of LBW among newborns delivered at public health facilities in Bishoftu town, Ethiopia. <b>Methods:</b> A facility-based unmatched case-control study was conducted at Bishoftu town. Data were collected from mothers having newborns with birth weight < 2500 gm (cases) and 2500 to 4000 gm (controls) using a pretested questionnaire and medical record review. Lastly, Epi Info 7 to enter the obtained data, and SPSS version 21 was used for analysis. Factors in the bivariate analysis with a <i>p</i> value less than 0.25 were added to the multivariable logistic regression, where a <i>p</i> value less than 0.05 was deemed statistically significant. <b>Results:</b>A total of 285 neonates (95 cases and 190 controls) were included in the study. Being not preeclampsia (AOR = 0.34; 95% CI: 0.13-0.88), lack of iron supplementation (AOR = 12.16; 95% CI: 5.40-27.42), preterm delivery (AOR = 7.49, 95% CI: 3.23-17.36), lack of information (AOR = 4.65, 95% CI: 1.37-15.750), and not experienced premature rupture of membranes (PROM) (AOR = 0.27; 95% CI: 0.08-0.91) were identified as statistically significant variables in LBW. <b>Conclusion:</b> LBW was significantly influenced by preeclampsia, PROM, missing iron-folate supplementation during pregnancy, and ignorance of the warning symptoms of premature delivery during pregnancy. Therefore, reducing LBW requires a lot of work, including developing effective interventions and monitoring policies.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"4873667"},"PeriodicalIF":2.6,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11257756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141722930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncological Outcome of Node-Positive Oral Squamous Cell Carcinomas Treated With Selective and Comprehensive Neck Dissection.","authors":"Jan Oliver Voss, Lea Freund, Felix Neumann, Kerstin Rubarth, Kilian Kreutzer, Steffen Sander, Evelyn Golembiewski, Friedrich Mrosk, Christian Doll, Carsten Rendenbach, Max Heiland, Steffen Koerdt","doi":"10.1155/2024/9543897","DOIUrl":"10.1155/2024/9543897","url":null,"abstract":"<p><p>Selective neck dissection (SND) is the treatment of choice in patients with oral squamous cell carcinomas (OSCCs) and clinically node-negative necks (cN0). The treatment of patients with positive-staged necks (cN+) includes SND as well as comprehensive neck dissection (CND). The clear benefit of one or the other remains under debate. We aim to address this lack of clarity by analysing patients with OSCC staged with clinically node-positive necks, treated with either CND or SND using a level-by-level approach. This retrospective study included patients diagnosed with OSCC with clinically (cN+) and pathologically (pN+) positive cervical lymph nodes (LNs) with clear neck level categorization during the years 2010-2019. In total, 74 patients were analysed. Cox regression analysis found no significance for the type of ND being an independent risk factor, neither for overall survival (OS) nor for disease-free survival (DFS). Regional recurrence of CND cases (5.77%) was comparable to SND cases (9.09%). For OS, extracapsular spread (ECS) and male sex were identified as independent risk factors with poorer outcome. pT-stage and ECS were found to be independent risk factors for DFS. The results of this study suggest that both CND and SND may be viable treatment options for certain patients with OSCC pN+.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"9543897"},"PeriodicalIF":2.6,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11257757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141722931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thymoquinone Increases the Sensitivity of SW-480 Colon Cancer Cells to 5-Fluorouracil.","authors":"Nima Zeinali, Vahid Mahmoudzadeh, Alireza Anarjani, Mohammad Ebrahimnejad, Bahman Yousefi, Amir Valizadeh","doi":"10.1155/2024/6231095","DOIUrl":"10.1155/2024/6231095","url":null,"abstract":"<p><p><b>Background:</b> Studies have concentrated on the therapeutic potential of thymoquinone (TQ), a natural polyphenol, in diverse malignancies, such as colorectal cancer. Nevertheless, the precise mechanisms of TQ-mediated anticancer properties are not yet fully elucidated. <b>Objective:</b> The present study has been designed to scrutinize the impact of TQ on 5-fluorouracil (5-FU)-mediated apoptosis in SW-480 cells. <b>Materials and Methods:</b> SW-480 cells were treated with TQ, 5-FU, and a combination of TQ + 5-FU. MTT assay was employed to assess cell viability. Quantitative real-time polymerase chain reaction (qRT-PCR) was applied to evaluate apoptotic markers comprising Bcl-2, Bax, and caspase-9 expression levels. The <i>γ</i>-H2AX protein expression was assessed by western blotting, and Annexin V flow cytometry was implemented to determine the apoptosis rate. <b>Results:</b> 5-FU significantly reversed the cell proliferation in a dose-dependent circumstance. The concurrent administration of TQ and 5-FU led to a substantial inhibition of cell growth in comparison to single treatments (<i>p</i> < 0.05). TQ also facilitated apoptosis via upregulating Bax and caspase-9 proapoptotic markers and suppressing antiapoptotic mediators, like Bcl-2. In addition, TQ augmented 5-FU-induced apoptosis in SW-480 cells. 5-FU, combined with TQ, increased the protein expression of <i>γ</i>-H2AX in SW-480 cells compared with groups treated with TQ and 5-FU alone. <b>Conclusion:</b> The present study's findings unveil the significance of TQ as a potential therapeutic substance in colorectal cancer, particularly through enhancing 5-FU-induced apoptosis.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"6231095"},"PeriodicalIF":2.6,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11251801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141625858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Step Purification of Catalase Enzyme From Human Blood Erythrocytes Using Affinity Chromatography Technique.","authors":"Kübra Çıkrıkcı, Nahit Gencer","doi":"10.1155/2024/2222098","DOIUrl":"10.1155/2024/2222098","url":null,"abstract":"<p><p>In this study, we aimed to isolate and purify catalase from human blood erythrocytes by using a newly synthesized affinity gel. The synthesized <i>ω</i>-amino hexyl agarose-1,2,3-triazole-5-carboxylic acid affinity gel was analyzed by FT-IR. Then, different buffer, pH, and ionic strength parameters were optimized to determine the equilibration, washing, and elution buffer conditions. The catalase was purified from human blood erythrocytes with a specific activity of 45.58 EU/mg, purification fold of 529.50, and a yield of 0.416% using the synthesized new affinity gel. The purity and molecular weight of the enzyme were analyzed by SDS-PAGE, and a single band at 60 kDa was observed for catalase. The optimum reaction temperature of the catalase was found to be 30°C, while the thermal stability temperature was 60°C. The Km and Vmax of the enzyme for hydrogen peroxide were calculated at 0.125 mM and 2500 U mL^-1, respectively.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"2222098"},"PeriodicalIF":2.6,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11251793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141625857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiological Evaluation of the Accuracy of Demirjian, Nolla, and Willems Methods for Dental Age Estimation in 3-17-Year-Old Iranian Children.","authors":"Benjamin Pliska, Azam Nahvi, Nikta Pakdaman, Sepideh Dadgar, Mehdi Aryana, Farhad Sobouti","doi":"10.1155/2024/8783660","DOIUrl":"10.1155/2024/8783660","url":null,"abstract":"<p><p><b>Background:</b> The stage of tooth formation is one of the most reliable indicators for predicting a patient's developmental age by radiographs. This study compared the accuracy of three distinct dental age estimation methods (Demirjian, Nolla, and Willems) in children aged 3-17 in the northern Iranian population. <b>Methods:</b> This cross-sectional study examined panoramic radiographs of 434 children aged 3-17 from Mazandaran Province, Iran, who had teeth 31-37 present on the left mandible. This study employed the Demirjian, Nolla, and Willems methods to estimate the dental age of the sample and compare it with the chronological age. The data were analyzed using SPSS v16. A paired <i>t</i>-test was used to compare chronological and dental ages. The Pearson correlation was used to correlate the chronological and dental ages. The errors of different methods were compared using the Wilcoxon test. <i>P</i> values < 0.05 were considered significant for all tests except Wilcoxon. For Wilcoxon, a <i>P</i> value < 0.017 was considered significant. <b>Results:</b> The three methods presented differing mean estimated ages. The Demirjian method delivered the highest mean, and all three methods differed significantly when compared in pairs. The results showed that the Demirjian method overestimated chronological age by 0.25 years (<i>P</i> < 0.001) in girls and 0.09 years (<i>P</i> = 0.28) in boys. The Willems method underestimated chronological age by 0.05 years (<i>P</i> = 0.47) in girls and 0.12 years (<i>P</i> = 0.13) in boys. The Nolla method underestimated chronological age by 0.41 years (<i>P</i> < 0.001) in girls and 0.40 years (<i>P</i> < 0.001) in boys. The accuracy of each method varied with the patient's age. <b>Conclusion:</b> According to the findings, the Willems method outperformed the Demirjian method, and the Demirjian method exceeded the Nolla method for estimating dental age in Iranian children aged 3-17. Overall, the Demirjian method overestimated the age of the study population, whereas the other two underestimated it.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"8783660"},"PeriodicalIF":2.6,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141578864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Scientific Literature Between Ultraprocessed Foods and Cancer: A Scientometric Mapping.","authors":"Fran Espinoza-Carhuancho, Carlos Quispe-Vicuña, Cesar Mauricio-Vilchez, Julia Medina, Luzmila Vilchez, Lucia Quispe-Tasayco, Frank Mayta-Tovalino","doi":"10.1155/2024/3763197","DOIUrl":"10.1155/2024/3763197","url":null,"abstract":"<p><p><b>Objective:</b> The objective of the study is to explore the scientific literature between ultraprocessed foods (UPFs) and cancer using a scientometric mapping. <b>Materials and Methods:</b> A Scopus search was conducted on February 4, 2024, limited to papers published between 2018 and 2023. We found 662 articles, 189 reviews, 68 book chapters, 13 conference papers, and 9 notes. The whole analysis included the evaluation of scholarly output by country/region, the number of scholarly papers produced (scholarly output), the number of views (view count), the field-weighted citation impact (FWCI). <b>Results:</b> In the analysis conducted for the period 2018-2023, a dataset was examined where the annual growth rate was 5.96%, indicating a sustained expansion of the literature. The average number of citations per paper was 18.56, underlining the impact and relevance of the publications. Sixty-six single-authored papers were identified, and international collaborations accounted for 27.23% of the collaborative efforts. The most prominent authors were Inge Huybrechts, Marc J.R. Gunter, and Edward Luciano Giovannucci. In terms of impact and visibility, Harvard University leads with 52 contributions and a field-weighted impact of 3.39. <b>Conclusions:</b> The literature in the field of UPFs and cancer has experienced a sustained expansion. The scientometric indicators reveal a high activity of recent academic contributions with significant impact.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"3763197"},"PeriodicalIF":2.6,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11226335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical Design Optimization of Distal Humerus Fracture Plates: A Review.","authors":"Radovan Zdero, Pawel Brzozowski, Emil H Schemitsch","doi":"10.1155/2024/6015794","DOIUrl":"10.1155/2024/6015794","url":null,"abstract":"<p><p>The goal of this article was to review studies on distal humerus fracture plates (DHFPs) to understand the biomechanical influence of systematically changing the plate or screw variables. The problem is that DHFPs are commonly used surgically, although complications can still occur, and it is unclear if implant configurations are always optimized using biomechanical criteria. A systematic search of the PubMed database was conducted to identify English-language biomechanical optimization studies of DHFPs that parametrically altered plate and/or screw variables to analyze their influence on engineering performance. Intraarticular and extraarticular fracture (EAF) data were separated and organized under commonly used biomechanical outcome metrics. The results identified 52 eligible DHFP studies, which evaluated various plate and screw variables. The most common plate variables evaluated were geometry, hole type, number, and position. Fewer studies assessed screw variables, with number and angle being the most common. However, no studies examined nonmetallic materials for plates or screws, which may be of interest in future research. Also, articles used various combinations of biomechanical outcome metrics, such as interfragmentary fracture motion, bone, plate, or screw stress, number of loading cycles to failure, and overall stiffness (Os) or failure strength (Fs). However, no study evaluated the bone stress under the plate to examine bone \"stress shielding,\" which may impact bone health clinically. Surgeons treating intraarticular and extraarticular distal humerus fractures should seriously consider two precontoured, long, thick, locked, and parallel plates that are secured by long, thick, and plate-to-plate screws that are located at staggered levels along the proximal parts of the plates, as well as an extra transfracture plate screw. Also, research engineers could improve new studies by perusing recommendations in future work (e.g., studying alternative nonmetallic materials or \"stress shielding\"), clinical ramifications (e.g., benefits of locked plates), and study quality (e.g., experimental validation of computational studies).</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2024 ","pages":"6015794"},"PeriodicalIF":2.6,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11223906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}