基于 3DP 的儿科药物制剂最新进展综述。

IF 2.6 3区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BioMed Research International Pub Date : 2024-09-26 eCollection Date: 2024-01-01 DOI:10.1155/2024/4875984
Aychew Mekuriaw Tegegne, Kassahun Dires Ayenew, Muluken Nigatu Selam
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引用次数: 0

摘要

三维打印(3DP)已成为制药行业中一项改变游戏规则的技术,为整个制药行业提供了新颖的制剂开发,改善了患者的个体化治疗。儿科人群是个体化治疗的主要目标之一。儿童是一个多样化的群体,包括新生儿、婴儿和学步期儿童,每个群体都有独特的生理特点。坚持治疗对儿科人群安全有效的药物治疗具有重要影响。改进治疗剂型以满足儿科人群的特殊需求,是制药行业面临的一项重大挑战。科学家们积极探索 3DP 这种快速原型制造方法,由于其操作简便、可重复性好、适应性强等优点,近年来在许多行业中崭露头角。本综述介绍了应用最广泛的 3DP 技术及其在儿科药物制剂开发中的应用。3DP 技术可以优化儿科用药方案和需要个性化治疗的病例,如老年病、肾功能损伤、肝功能损伤、危重病人、妊娠人群和具有非线性药代动力学的药物。3DP 专业技术的快速发展,加上药用油墨的推出,为患者剂型定制带来了巨大的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Review on Recent Advance of 3DP-Based Pediatric Drug Formulations.

Three-dimensional printing (3DP) has emerged as a game-changing technology in the pharmaceutical industry, providing novel formulation development in the pharmaceutical sector as a whole, which improved patients' individualized therapy. The pediatric population is among the key targets for individualized therapy. Children are a diverse group that includes neonates, infants, and toddlers, each with unique physiological characteristics. Treatment adherence has a significant impact on safe and effective pharmacotherapy in the pediatric population. Improvement of therapeutic dosage forms that provide for the special demands of the pediatric population is a significant challenge for the pharmaceutical industry. Scientists have actively explored 3DP, a quick prototype manufacturing method that has emerged in recent years from many occupations due to its benefits of modest operation, excellent reproducibility, and vast adaptability. This review illuminates the most widely used 3DP technology and its application in the development of pediatric-friendly drug formulations. This 3DP technology allows optimization of pediatric dosage regimens and cases that require individualized treatment, such as geriatrics, renal impairment, liver impairment, critically ill, pregnancy populations, and drugs with nonlinear pharmacokinetics. The fast evolution of 3DP expertise, in addition to the introduction of pharmaceutical inks, has enormous promise for patient dosage form customization.

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来源期刊
BioMed Research International
BioMed Research International BIOTECHNOLOGY & APPLIED MICROBIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
6.70
自引率
0.00%
发文量
1942
审稿时长
19 weeks
期刊介绍: BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
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