BioMed Research International最新文献

{"title":"Accuracy and Reliability of Dental Age Estimation Methods in Iranian Children: A Systematic Review and Meta-Analysis.","authors":"Razieh Jabbarian, Mehdi Ranjbaran, Aida Mokhlesi","doi":"10.1155/bmri/9351167","DOIUrl":"10.1155/bmri/9351167","url":null,"abstract":"<p><strong>Objectives: </strong>This study is aimed at systematically evaluating the accuracy and reliability of dental age (DA) estimation methods and conducting a meta-analysis of studies on different DA estimation methods in Iranian children.</p><p><strong>Methods: </strong>A systematic search of English and Persian literature from database inception to March 2024 was conducted across international and national databases to identify eligible studies on DA estimation using radiographs in Iranian children. Studies that used dental radiographs from healthy individuals aged 3-18 years and reported the mean difference (MD) between DA and chronological age (CA) were included. The meta-analysis calculated the MD between dental and chronological age, with 95% confidence intervals (CIs), to assess the applicability of the DA method for estimating CA in the Iranian population.</p><p><strong>Results: </strong>Twenty-seven eligible published articles were included in this study. Demirjian's method overestimated age (overall MD: males: +0.784 years; females: +0.323 years). Among the alternative methods studied in the systematic review, Moorrees and Nolla's methods tended to underestimate age, whereas Cameriere, Smith, and London Atlas'methods tended to overestimate age.</p><p><strong>Conclusion: </strong>Most methods studied consistently overestimated age and should be used cautiously in forensic age estimation, underscoring the importance of tailoring methods such as the Demarjian method for the Iranian population to ensure accuracy and relevance in professional practice. Additional studies employing similar methodologies and focusing on the customization of dental age estimation methods are recommended to improve accuracy and applicability across diverse populations.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 1","pages":"e9351167"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13265831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148249072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived Self-Efficacy and Its Determinants for Noncommunicable Disease Prevention Among Adults in Southern Ethiopia: A Community-Based Cross-Sectional Study.","authors":"Habtamu Endashaw Hareru, Mesfin Abebe, Berhanu G Debela, Tizalegn Tesfaye Mamo, Yohannes Addisu Wondimagegne","doi":"10.1155/bmri/3904968","DOIUrl":"10.1155/bmri/3904968","url":null,"abstract":"<p><strong>Background: </strong>Noncommunicable diseases (NCDs) are the leading causes of morbidity and mortality worldwide. The burden of NCD-related morbidity and mortality can be reduced through the adoption of healthy lifestyle behaviors and the utilization of preventive healthcare services. Self-efficacy plays a crucial role in maintaining healthy behavior and improving health outcomes. However, there is limited evidence regarding the magnitude of perceived self-efficacy in the study area. Therefore, this study is aimed at assessing the magnitude of perceived self-efficacy and its associated factors in preventing NCDs among adult residents in the Gedeo Zone, Southern Ethiopia.</p><p><strong>Methods: </strong>A community-based cross-sectional study was conducted from November 1, 2023, to January 1, 2024, among adult residents of the Gedeo Zone, Southern Ethiopia. A multistage sampling technique was employed to select 620 participants. Data were collected using interview-administered structured questionnaires through KoboToolbox and exported to STATA Version 16 for analysis. Descriptive statistics were computed, and binary logistic regression analysis was performed to identify candidate variables associated with perceived self-efficacy in preventing NCDs. Variables with p value < 0.05 in the multivariable model were considered statistically significant. Adjusted odds ratios (AORs) with 95% confidence intervals (CIs) were calculated and reported.</p><p><strong>Results: </strong>Overall, 56.5% (95% CI: 52.5%-60.3%) of participants had high perceived self-efficacy toward engaging in NCD preventive behaviors. Middle-aged adults (AOR = 1.81; 95% CI: 1.09, 3.01), older adults (AOR = 4.31; 95% CI: 2.08, 8.07), participants reporting good perceived general health status (AOR = 2.94; 95% CI: 1.38, 6.28), perceived benefit of health action (AOR = 5.54; 95% CI: 3.32, 9.25), and perceived cues to action (AOR = 4.35; 95% CI: 2.75, 6.88) were positively associated with high perceived self-efficacy in preventing NCDs. However, perceived barriers to health actions (AOR = 0.58; 95% CI: 0.38, 0.88) were negatively associated with high perceived self-efficacy.</p><p><strong>Conclusion and recommendations: </strong>The study found that more than half of the participants demonstrated high perceived self-efficacy in preventing NCDs. Being middle or older, having a good perceived general health status, perceiving benefits of health actions, and having cues to action were positively associated with self-efficacy, whereas perceived barriers to health actions were negatively associated with perceived self-efficacy. These findings suggest that policymakers and healthcare providers should strengthen community-based health promotion and social and behavior change interventions aimed at improving individuals' efficacy in engaging in NCD preventive behaviors.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 1","pages":"e3904968"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13324245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148366892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated Fatty Acid Binding Protein 4 (FABP4) Associated With Liver Damage and Kidney Complications in Thalassemia Patients.","authors":"Rawia Yusef Al Belbesi, Manal Mohammed Abbas, Ali Abu Siyam, Sima Zein","doi":"10.1155/bmri/3090639","DOIUrl":"10.1155/bmri/3090639","url":null,"abstract":"<p><strong>Background: </strong>Thalassemia is considered a significant health concern. Previous studies had shown that numerous adipokines, including fatty acid binding protein 4 (FABP4), might contribute to the development of complications in thalassemia.</p><p><strong>Objectives: </strong>This study is aimed at investigating FABP4 levels in thalassemia major patients receiving regular blood transfusions as well as to explore the association between FABP4 and target organ functioning as kidney and liver.</p><p><strong>Method: </strong>Serum samples were collected from 154 individuals with thalassemia major and subjected to various analyses, including hematological assessments, biochemical evaluations (kidney and liver functions), and immunological screenings using enzyme-linked immunosorbent assay (ELISA).</p><p><strong>Results: </strong>Examination of sociodemographic and disease-related factors indicated osteoporosis emerging as the predominant comorbidity. Elevated ferritin levels, an increased platelets (PLT) count, higher nucleated red blood cell (NRBC) count, and elevated bilirubin (BIL) levels in patient serum were observed. Conversely, creatinine levels were significantly low, with a mean of 21.7 and 25.4 μmol/L in females and males, respectively. FABP4 levels exhibited more frequent increases in females of p value = 0.03, particularly in the age groups of (13-18, 19-30) years; respectively, FABP4 levels had a significant difference of p value = 0.003 with the aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio.</p><p><strong>Conclusion: </strong>A significant difference was seen between serum FABP4 and bilirubin and AST/ALT ratio, showing a connection between serum FABP4 and liver injury and kidney complications. Consequently, while further studies are essential for a comprehensive exploration of this hypothesis, serum FABP4 may have a potential role in chronic diseases in thalassemia patients.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 1","pages":"e3090639"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Organoleptic Properties Simulation of a Placebo of Raw Food Material to a Chinese Medicine Oral Liquid FYTF-919.","authors":"Wanzhen Cui, Daojin Xue, Wenwei Ouyang, Yang Zhao, Meiling Xuan, Li Zhou, Guo Ke, Yimeng Gao, Linghui Kong, Yajie Chen, Juan Huang, Haiding Huang, Gang Lu, Liling Zeng, Tao Huang, Lili Song, Jianwen Guo, Zehuai Wen","doi":"10.1155/bmri/9000068","DOIUrl":"10.1155/bmri/9000068","url":null,"abstract":"<p><strong>Background: </strong>Research on blinding and physical consistency between placebo and Chinese medicine is in early stages. We complement novel methodologies for assessing blinding and physical consistency meanwhile investigate different roles of the two evaluations, taking Chinese botanical drug FYTF-919 with matched placebo as an example.</p><p><strong>Methods: </strong>Subjective evaluation through a clinical trial and objective evaluation by intelligent sensory analysis technology were used in this study. Eligible individuals were recruited and randomly provided FYTF-919 or placebo. Participants were instructed to determine nature of the substance (FYTF-919 or placebo) and compare odor and taste of the given substance with true FYTF-919. Objective evaluation on odor and taste properties was conducted by E-nose and E-tongue.</p><p><strong>Results: </strong>Forty-seven participants completed this trial. More than half participants identified placebo as FYTF-919; comparable proportions of participants in each group identified testing drug as FYTF-919. There's no significant difference in taste score between two groups. Higher odor score for FYTF-919 was associated with medical experience. Consistent with the clinical trial findings, intelligent machines-based sensory evaluation revealed that the two drugs could be confused in taste, whereas their odors were distinguishable.</p><p><strong>Conclusions: </strong>The placebo was effectively blinded to the traditional Chinese medicine in this study. However, the similarity between the drug and the placebo has not been fully confirmed, as their odor might be detected by the E-nose and medical staff. Therefore, medicine dispensing by dedicated personnel and preventing medical staff from having access to the investigational drugs are necessary for successful blinding throughout the clinical trial.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier: NCT05483595.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 1","pages":"e9000068"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Different Whitening Toothpastes on the Color of Aged Zirconia-Reinforced Lithium Silicate Ceramics After Immersion in an Acidic Beverage.","authors":"Ali Reza Akbarnia, Elham Ahmadi, Ladan Ranjbar Omrani, Amir Mohammad Azizzadeh, Ahmad Reza Shamshiri, Fatemeh Farshad, Mahdi Abbasi","doi":"10.1155/bmri/6451392","DOIUrl":"10.1155/bmri/6451392","url":null,"abstract":"<p><strong>Introduction: </strong>This study is aimed at comparing the effects of different whitening toothpastes on the color of aged ZLS ceramics after immersion in an acidic beverage.</p><p><strong>Materials and methods: </strong>In this in vitro study, 72 cylindrical (2×10 mm) ZLS ceramic specimens were sintered, polished, and randomly assigned to six groups (n = 12) of distilled water (D), distilled water + Colgate Total Whitening (DT), distilled water + Perfect White black (DP), cola (C), cola + Colgate Total Whitening (CT), and cola + Perfect White black (CP). After 5000 thermal cycles, the specimens were immersed in an acidic beverage for 6 days. The specimens in groups CP, CT, DP, and DT were brushed at 40 rpm for 2.33 min. The CIEL ^∗a ^∗b ^∗ color parameters were measured spectrophotometrically before and after aging and toothbrushing. Data were analyzed by one-way ANOVA (alpha = 0.05).</p><p><strong>Results: </strong>The color change (ΔE) was not clinically detectable in any group (< 3.3). ΔE of the CT group was significantly greater than that of the C (mean difference: 0.12, p < 0.05) and the CP (mean difference: 0.13, p < 0.05) groups. ΔL of the C group was significantly greater than that of the CP group (mean difference: 0.21, p < 0.05). The differences in Δa and Δb were not significant among the groups (p > 0.05).</p><p><strong>Conclusions: </strong>The application of Colgate Total Whitening and Perfect White black toothpaste for 6 weeks, along with simulated 6-month cola consumption, did not cause a clinically detectable change in the color of aged ZLS ceramics.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 1","pages":"e6451392"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: \"3D Culture System for Liver Tissue Mimicking Hepatic Plates for Improvement of Human Hepatocyte (C3A) Function and Polarity\".","authors":"BioMed Research International","doi":"10.1155/bmri/9763128","DOIUrl":"10.1155/bmri/9763128","url":null,"abstract":"","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 1","pages":"e9763128"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13108702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147761173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological and Clinical Risk Factors for Breast Cancer-Related Lymphedema: A Case-Control Study From Hamadan, Western Iran.","authors":"Soulmaz Rahbar, Hojjat Radinmehr, Mohammad Reza Asadi, Tayebeh Roghani, Azade Tabatabaei, Abdolazim Sedighi Pashaki, Erfan Ayubi","doi":"10.1155/bmri/8099570","DOIUrl":"10.1155/bmri/8099570","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer-related lymphedema (BCRL) is one of main issues following treatments in patients with breast cancer (BC). The current study is aimed at evaluating epidemiological and clinical risk factors for BCRL in female patients with BC.</p><p><strong>Methods: </strong>In a case-control study design from October 2024 to March 2025, female BC patients with and without BCRL were recruited from the Lymphedema Physiotherapy Clinic and the Cancer Therapeutic and Diagnosis Imaging Center in Hamadan, Western Iran. Patient, tumor, and treatment characteristics were gathered via interview and reviewing medical and pathology records.</p><p><strong>Results: </strong>Overall, 230 patients (127 cases and 103 controls) were included. The multivariable analysis revealed several potential risk factors for BCRL: older age at diagnosis (odds ratio [OR] = 1.05; 95% confidence interval [CI], 1.00, 1.10), urban residency (4.76; 1.20, 20.00), axillary lymph node dissection number of 6-9 compared to ≤ 5 (2.54; 0.99, 6.49), pathology grade of 2 (7.11; 1.47, 34.27) and 3 (6.53; 1.32, 32.32) compared to Grade 1, mastectomy versus lumpectomy (2.86; 1.23, 6.67), receiving chemotherapy (9.55; 1.23, 73.95), and positive progesterone receptor (PR) status (2.56; 1.16, 5.55).</p><p><strong>Conclusion: </strong>The combination of patient, tumor, and treatment characteristics may be associated with BCRL, highlighting the close monitoring of high-risk patients (older age, high-grade tumors, mastectomy, and PR-positive) in Western Iran.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 1","pages":"e8099570"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13578934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Combination Therapy With Caffeine and Naringin on Insulin Resistance and Renal Function in a Nonalcoholic Fatty Liver Disease Rat Model.","authors":"Mehrasa Azizollahi, Maedeh Ghasemi, Zahra Nasehi, Mahdi Amani, Fouzieh Zadhoush","doi":"10.1155/bmri/9927792","DOIUrl":"10.1155/bmri/9927792","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic kidney disease (CKD) is a major global health concern, and evidence indicates that non-alcoholic fatty liver disease (NAFLD) independently increases its risk and progression. This connection involves shared pathways such as chronic inflammation, oxidative stress, and insulin resistance, which can worsen renal injury. Caffeine (CAF) and naringin (NAR), with their antioxidant and anti-inflammatory properties, may provide protective effects on both NAFLD and CKD. This study evaluated the impact of combined CAF and NAR treatment on insulin resistance and renal function in a high-fat diet (HFD) induced NAFLD rat model.</p><p><strong>Materials and methods: </strong>Thirty-five male Wistar rats were randomly assigned to five groups (control, HFD, HFD + CAF, HFD + NAR, HFD + CAF + NAR; n = 7 per group). The HFD groups were fed a HFD (51% calories from fat) for 16 weeks, and from Week 10, received oral treatments with CAF (50 mg/kg/day), NAR (12.5 mg/kg/day), or their combination for 6 weeks. Key outcomes, including insulin resistance (HOMA-IR), renal function (BUN, creatinine, and eGFR), and systemic inflammation (hs-CRP) were evaluated at the study's conclusion.</p><p><strong>Findings: </strong>HFD significantly increased glucose, HOMA-IR, BUN, and hs-CRP (p < 0.0001), as well as insulin and creatinine levels (p < 0.001), whereas eGFR decreased (p < 0.01) compared with controls. Treatment with CAF or NAR partially improved these parameters. The combination therapy produced the most pronounced effects, significantly lowering HOMA-IR and creatinine (p < 0.0001), BUN and glucose (p < 0.001), insulin (p <0.01), and hs-CRP levels (p <0.05), while increasing eGFR (p < 0.01).</p><p><strong>Conclusion: </strong>The CAF-NAR combination demonstrated superior effects compared with monotherapies in the NAFLD rat model, improving insulin resistance, enhancing renal function, and reducing systemic inflammation, thereby highlighting its potential as a promising approach for managing NAFLD-related metabolic and renal complications.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 1","pages":"e9927792"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13583926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148987994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Characterization of Odontogenic Differentiation from Human Dental Pulp Stem Cells Using TMT-Based Proteomic Analysis\".","authors":"","doi":"10.1155/bmri/9797869","DOIUrl":"10.1155/bmri/9797869","url":null,"abstract":"","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 1","pages":"e9797869"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13197615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148004575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the Research Growth and Citation Impact of Scholarly Works on Sickle Cell Disease in Tanzania: A Scientometric Study.","authors":"Sydney E Msonde, Emmanuel C Balandya, Upendo Masamu","doi":"10.1155/bmri/3018829","DOIUrl":"10.1155/bmri/3018829","url":null,"abstract":"<p><p>Sickle cell disease (SCD) remains a major public health concern in Tanzania, where research efforts associated with the Muhimbili Sickle Cell (MSC) Program have contributed to increased scientific output. However, there is limited consolidated evidence on bibliometric trends and research influence in this field. This study examined publication trends, authorship patterns, institutional contributions, and citation-based research influence of SCD research in Tanzania. A bibliometric analysis was conducted using publications retrieved from Dimensions, Scopus, Web of Science, and Google Scholar for SCD research involving Tanzanian scholars, covering 2003-2024. Records were included if they were peer-reviewed (articles/reviews) and/or scholarly publications indexed in the selected databases, included at least one author affiliated with a Tanzanian institution, and focused on SCD/hemoglobinopathies or related anemia conditions in Tanzania. English-language, full-text, accessible records were included, whereas studies unrelated to Tanzania-focused SCD or hemoglobinopathies, editorials, opinion pieces, letters, duplicates, records lacking full texts or bibliographic information, or those outside the timeframe were excluded. Google Scholar was used to capture additional records and citation signals that may not be uniformly indexed in other databases. Data were extracted, cleaned, and analyzed using Microsoft Excel, whereas VOSviewer and OriginPro were used for network mapping and visualization. Findings show a progressive/steady increase in SCD research output, with a peak in 2022 and the highest citation accumulation in 2023, indicating growing visibility of recent work. The most productive institutions were MUHAS, NIMR, and CUHAS, and key contributors included Makani J., Nkya S. W., and Sangeda R. Z. High-impact journals included PLOS One, Malaria Journal, and Blood. The thematic distribution of research output was mainly concentrated in clinical medicine, immunology, and biochemistry. The study demonstrates sustained growth in research visibility and impact in Tanzania, while showing that productivity remains concentrated among a limited number of institutions and authors, highlighting the need for broader participation and thematic diversification.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 1","pages":"e3018829"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13451852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148688557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}