BioMed Research International最新文献

{"title":"RETRACTION: Downregulation of CRABP2 Inhibit the Tumorigenesis of Hepatocellular Carcinoma in Vivo and in Vitro.","authors":"BioMed Research International","doi":"10.1155/bmri/9802538","DOIUrl":"https://doi.org/10.1155/bmri/9802538","url":null,"abstract":"","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 1","pages":"e9802538"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148142524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Epinephrine Enhances the Response of Macrophages under LPS Stimulation.","authors":"BioMed Research International","doi":"10.1155/bmri/9864769","DOIUrl":"10.1155/bmri/9864769","url":null,"abstract":"","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 1","pages":"e9864769"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13261286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148223013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening Biomedical Research and Healthcare in Africa Through Localized Reagent Production.","authors":"Benedict Ofori, Righteous Kwaku Agoha, Kwamina Nyame, Kwabena Amofa Nketia Sarpong","doi":"10.1155/bmri/7361394","DOIUrl":"10.1155/bmri/7361394","url":null,"abstract":"<p><p>Africa is home to 15% of the global population and bears nearly a quarter of the world's disease burden. However, it faces significant challenges in biomedical research and healthcare due to limited access to essential reagents. This review examines the critical need for localized reagent production to strengthen biomedical research and healthcare across the continent. The reagent market in Africa is characterized by varying levels of development, and the current production capacity falls short of meeting the biomedical research and healthcare demands. The reliance on imported reagents results in high costs, lengthy procurement processes, and vulnerability to supply chain disruptions. Establishing reagent production facilities across the continent can enhance self-sufficiency, reduce costs, and improve biomedical research tailored to the unique health challenges faced by African populations. Such efforts can be supported by strategic public-private partnerships and international collaborations, leveraging the successes of the existing pharmaceutical investments across the continent and local capacity-building initiatives. Regional collaboration, market development, technical training, infrastructure, regulatory frameworks, and sustainable funding are essential to ensure long-term success. Developing skilled human capital and creating a unified market through initiatives like the African Continental Free Trade Area can attract investment and ensure economic sustainability of local reagent production. Together, these measures can significantly improve biomedical research output and healthcare response capabilities, preparing the continent for future health emergencies.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 1","pages":"e7361394"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Key Genes and Pathways Associated With Gender Differences in Pulmonary Arterial Hypertension Based on Bioinformatic Approaches.","authors":"Mohammad Panahi, Reyhaneh Kalhor, Mohammad-Hossein Mokhtarian, Fatemeh Javaheri Tehrani, Zinat Shams, Hourieh Kalhor","doi":"10.1155/bmri/9938078","DOIUrl":"10.1155/bmri/9938078","url":null,"abstract":"<p><p>Pulmonary arterial hypertension (PAH) is a complex disease with multiple contributing factors. Epidemiological data showed that women are more susceptible to PAH, but they tend to have better right ventricular (RV) function and prognosis compared to men. The mechanisms behind these gender differences are not well understood. Using a variety of bioinformatic techniques, this study was aimed at investigating the major genes and putative pathways driving PAH in females. Consequently, microarray datasets GSE38267 and GSE131793 were obtained from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) in patients with PAH and healthy men and females were found via the use of volcano plots and Venn diagrams. Female-specific DEGs were selected for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses, with results visualized via R and Cytoscape software. The protein-protein interactions (PPIs) of female-specific DEGs were analyzed using the NetworkAnalyst online tool. Among identified DEGs, 98 DEGs were specific to males, 145 were shared among sexes, and 741 were unique to females. To focus on DEGs that are specific to female, male and shared DEGs were excluded. GO enrichment analysis revealed that these DEGs in females were mostly involved in cell-matrix adhesion, mucosal innate immune response, and hydrogen peroxide catabolism. Significant KEGG pathways included fluid shear stress, atherosclerosis, arrhythmogenic RV cardiomyopathy, and ECM-receptor interaction. Bioinformatic analysis of microarray datasets led to the identification of 10 female-specific hub genes, SLC4A1, THBS1, ITGB3, IL7R, CCR7, SNCA, CTNNB1, SELP, GZMK, and ITGA2B, from DEGs between control and PAH samples in females. These hub genes that are specific to females have the potential to be significant in the pathogenesis of PAH in females. These hub genes may be promising candidates for improving our knowledge of sex-related processes in PAH; nevertheless, experimental confirmation is necessary before considering them as biomarkers or therapeutic targets.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 1","pages":"e9938078"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147455402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Hotspots and Trends in Ciliopathies: A Bibliometric and Visualization Analysis.","authors":"Qian Dong, Jinhao Zhu, Jiang Liu, Huan Xu","doi":"10.1155/bmri/9033339","DOIUrl":"10.1155/bmri/9033339","url":null,"abstract":"<p><strong>Purpose: </strong>This study conducted a comprehensive bibliometric analysis of research hotspots and development trends in ciliopathies to provide an overview of the global research landscape.</p><p><strong>Methods: </strong>The study retrieved relevant literature on ciliopathies from the Web of Science Core Collection up to July 27, 2024. Using the CiteSpace visualization software, co-occurrence network analyses were performed on the authors, institutions, and keywords of the literature.</p><p><strong>Results: </strong>A total of 1821 papers were included, demonstrating a wave-like increasing trend in annual publication volume. Among English-language publications, Omran, Heymut had the highest number of articles. The cooperation network among the United States, the United Kingdom, and China was broader than that of other countries or regions. Omran, Heymut had the highest number of publications (64), placing him among the most prolific authors (defined as ≥ 60 publications); Knowles, Michael R. (58) and Leigh, Margaret W. (51) ranked second and third, respectively. Research hotspots mainly focused on functional mutations, congenital heart disease, cystic fibrosis, dyskinesia, primary ciliary dyskinesia, and genetics. Current ongoing hotspots include genetics, dynein, multiple morphological abnormalities, motile cilia, male infertility, variants, and sperm flagella.</p><p><strong>Conclusion: </strong>This study delineates the evolutionary trajectory of research themes, identifies established and emerging hotspots, and maps the global collaborative network. These findings provide a systematic, evidence-based framework to guide future research directions, foster cross-disciplinary collaboration, and optimize resource allocation in the ciliopathy field.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 1","pages":"e9033339"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147502985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Biocompatibility of Portland-Based Endodontic Cements Containing Niobium and/or Bismuth Oxides in Rat Subcutaneous Tissue.","authors":"Raphael Victor Silva Andrade, Rafaela Alcindo Silva de Souza Fé, Vladimir Galdino Sabino, Carlos Augusto Galvão Barboza, Maria Luiza Diniz de Sousa Lopes, Nizyara Costa da Silva, Valkleidson Santos de Araujo, Amanda Silveira da Silva, Raimundo Fernandes de Araujo Junior, Naianne Kelly Clebis, Isadora Luisa Gomes da Silva, Pedro Catalão Moura, Sofia Pessanha, Aurigena Antunes de Araújo","doi":"10.1155/bmri/6614534","DOIUrl":"10.1155/bmri/6614534","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the in vitro cytocompatibility and osteogenic potential and the in vivo biocompatibility of two experimental endodontic cements based on Portland cement combined with either Nb2O₅ (F6) and/or bismuth oxide (F7) in a rat subcutaneous implantation model.</p><p><strong>Methods: </strong>For the in vitro study, MC3T3-E1 preosteoblastic cells were exposed to MTA Angelus, F6, or F7, and cell viability was assessed at 24 and 48 h using the Alamar Blue assay. Osteogenic differentiation was evaluated by alkaline phosphatase (ALP) activity after 14 days. For the in vivo analysis, polyethylene tubes containing the materials were implanted into the dorsal subcutaneous tissue of rats and evaluated at 7, 14, and 30 days, with empty tubes used as controls. Histological and histochemical analyses included hematoxylin and eosin (H&E), Picrosirius Red, Von Kossa staining, and TNF-α immunohistochemistry. Chemical characterization was performed using Raman spectroscopy and X-ray fluorescence (XRF). In vitro data were analyzed using one-way ANOVA followed by Tukey's post hoc test, while semiquantitative histological data were analyzed using the Kruskal-Wallis test followed by Dunn's test. A significance level of 5% (p < 0.05) was adopted.</p><p><strong>Results: </strong>In vitro, F6 showed cell viability comparable to MTA Angelus at both 24 h (36.22 ± 2.66% vs. 35.75 ± 1.18%) and 48 h (34.18 ± 3.09% vs. 35.20 ± 2.35%) (p > 0.05). In contrast, F7 significantly reduced cell viability at 24 h (25.61 ± 1.11%) compared with MTA Angelus (p = 0.002), although no difference was observed at 48 h (p > 0.05). ALP activity after 14 days did not differ significantly among MTA Angelus (1.90 ± 1.23 UI/L/g), F6 (1.71 ± 0.88 UI/L/g), and F7 (1.78 ± 1.34 UI/L/g) (p = 0.703). In vivo, F6 induced mild to moderate inflammatory responses at the early time period, with a significant reduction by Day 14 and minimal inflammation at Day 30, comparable to MTA Angelus. No multinucleated giant cells were observed, and TNF-α expression was moderate. Von Kossa staining and XRF confirmed calcium deposition, while Raman spectroscopy detected niobium species in peri-implant tissues, indicating bioactivity. Picrosirius Red staining demonstrated progressive collagen fiber organization. Conversely, F7 elicited a pronounced and persistent inflammatory response characterized by multinucleated giant cells, intense TNF-α expression, and bismuth retention in surrounding tissues, as confirmed by XRF, with no niobium-related signals detected by Raman analysis.</p><p><strong>Conclusion: </strong>The niobium-containing cement (F6) demonstrated favorable in vitro cytocompatibility and in vivo biocompatibility.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 1","pages":"e6614534"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13042350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Pilot Study on the Short-Term Effects of an Electric Knee-Ankle-Foot Orthosis on Gait Performance and Physiological Cost Index in Patients With Hemiplegia: Influence of Initial Balance Ability Assessed by the Berg Balance Scale.","authors":"Hyuk-Jae Choi, Yoon Heo, Jong-Won Lee, Hyeonseok Cho, Ju-Hwan Bae, In Ho Hwang, Mi Jung Kim, Chang-Yong Ko","doi":"10.1155/bmri/5528235","DOIUrl":"10.1155/bmri/5528235","url":null,"abstract":"<p><p>Gait impairment is one of the most disabling consequences of stroke and substantially limits functional independence. While traditional orthoses provide joint stabilization, they often restrict natural motion and lack adaptive support. This study is aimed at evaluating the short-term effects of an electric knee-ankle-foot orthosis (E-KAFO) on gait performance and energy efficiency in patients with hemiplegia and at assessing how baseline balance ability, measured using the Berg Balance Scale (BBS), influences outcomes. This pre-post intervention, nonrandomized study enrolled poststroke survivors (n = 22), who were stratified into high- (BBS > 45) and low- (BBS ≤ 45) balance groups (HBG and LBG, respectively). Participants underwent gait assessments under two conditions: body-powered condition (BP_C), to evaluate rehabilitation effects independently of the device, and E-KAFO_C, to assess short-term assistive efficacy immediately after device use. All assessments were conducted before and after a 3-week intervention comprising seven E-KAFO training sessions. The primary outcome was gait speed, measured using the 5-m walk test (5-mWT). The 3-min and 6-min walk tests (3-MWT and 6-MWT) and the physiological cost index (PCI) were also evaluated to assess gait endurance and energy efficiency. The 5-mWT and 3-MWT/6-MWT were performed in randomized order to minimize order-related bias. No standard rehabilitation-only control group was included. Assistive effects (E-KAFO_C) and rehabilitative effects (BP_C) were analyzed and reported separately. Two-way repeated measures analysis of variance was used to assess the effects of group, time, and their interaction. Significant improvements in gait speed and endurance were observed across both conditions, with the LBG showing greater relative gains postintervention. In the E-KAFO_C condition, the LBG demonstrated a 33.31% increase in 5-mWT speed and a 25.51% increase in 3-MWT distance. Notably, PCI decreased in both groups, although the reduction was significant only in the LBG. These findings underscore the distinction between the short-term assistive benefits of the E-KAFO and the rehabilitative improvements captured by BP_C outcomes, emphasizing that BP_C results serve as the primary indicator of rehabilitation effectiveness. Importantly, baseline balance ability assessed by the BBS influenced assistive and rehabilitative responses, supporting its relevance for patient stratification. Given the exploratory design and limited sample size, these findings are hypothesis-generating and require confirmation in larger randomized controlled trials. TRIAL REGISTRATION: WHO International Clinical Trials Registry Platform, supported by the Korea Disease Control and Prevention Agency (KDCA): KCT0011412.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 1","pages":"e5528235"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13051853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Infective Effect of Anacardium occidentale L. Flowers Against Eskape Group Bacteria In Vitro, In Vivo, and In Silico.","authors":"Pâmela Gomes Santos, Josivan Regis Farias, Simone Batista Muniz, Danielle Cristine Gomes Franco, Ariadina Jansen Campos Fontes, Liane Maria Rodrigues Santos, Flavia Raquel Fernandes Nascimento, Claudia Quintino Rocha, Alexandra Martins Dos Santos Soares, Rosane Nassar Meireles Guerra","doi":"10.1155/bmri/6579435","DOIUrl":"10.1155/bmri/6579435","url":null,"abstract":"<p><strong>Background/objectives: </strong>The study evaluated the in vitro antibacterial activity of the ethanolic extract of Anacardium occidentale flowers (EHAo) against ESKAPE pathogens and investigated the in vivo effects of the extract in Tenebrio molitor lethally infected with Staphylococcus aureus. In silico analyses investigated the affinity of compounds with sortase A.</p><p><strong>Methods: </strong>Chemical composition was characterized by HPLC and LC-MS. Antibacterial activity was determined by minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and assays of adhesion and biofilm formation using S. aureus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, and clinical MRSA strains. In vivo toxicity and antimicrobial efficacy were assessed in T. molitor larvae infected with S. aureus (10⁵ CFU/mL) and treated with PBS, ciprofloxacin (1.56 μg/mL), or EHAo (3.12-12.5 mg/mL). Molecular docking evaluated the interactions between the chemical compounds identified in EHAo and the sortase A active site.</p><p><strong>Results: </strong>EHAo contained shikimic acid, gallic acid, quercetin, isoquercetin, galloyl-glucose, digalloyl-glucose, and tetragalloylglucose isomers. The extract exhibited bactericidal activity (MIC 1.25-6.25 mg/mL), with the strongest effects against S. aureus, MRSA, and E. faecalis. EHAo inhibited adhesion and biofilm formation, except in K. pneumoniae. The extract showed low toxicity in vivo and was efficient in improving the larvae's survival following lethal infection with S. aureus. All compounds showed affinity to sortase A active site. However, digalloyl-glucose displayed the highest predicted affinity.</p><p><strong>Conclusions: </strong>EHAo reduces bacterial virulence and improves survival in S. aureus-infected larvae, an activity probably related to the bactericidal activity, inhibition of adhesion and biofilm formation, and interaction with the sortase A active site.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 1","pages":"e6579435"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13385197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148534947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese Medicine Bone-Setting Techniques Research Progress for the Treatment of Knee Osteoarthritis.","authors":"Qiao Fan, Ming-Yu Zhao, Xiang-Dong Zhang, Tian-Yun Chu, Zhao-Xi Kou, Qi Zhao, Nan Wang, Xiao-Ying Liu, Jia-Hao Zhang, Qiu-Sheng Wang","doi":"10.1155/bmri/9073869","DOIUrl":"10.1155/bmri/9073869","url":null,"abstract":"<p><p>This paper systematically reviews the biological mechanisms and clinical applications of traditional Chinese medicine (TCM) manual therapy in the treatment of knee osteoarthritis (KOA), explores the scientific basis for its multipathway intervention in improving joint function, and analyzes the current research limitations. KOA is a degenerative joint disease characterized by articular cartilage degeneration, synovitis, and osteophyte formation. Its pathogenesis is closely related to mechanical stress imbalance, abnormal elevation of proinflammatory factors (e.g., IL-1β and TNF-α), and chondrocyte metabolic dysfunction. TCM manual therapy of KOA is to regulate the metabolism of articular cartilage and the production of inflammatory factors through the release of local soft tissue of the knee joint and supplemented by joint motion manipulation. Clinically, KOA should be treated from the perspective of syndrome differentiation, combined with modern anatomy and biomechanics, and pay attention to the circulation of the channel tendons and restore the relative stability of the human structure. In addition, manipulation combined with relevant Chinese medicine therapies such as fumigation, acupoint injection, acupuncture, and so on. can effectively relieve KOA in the elderly. However, there are still some problems in the treatment of KOA by TCM manipulation: for example, the pathogenesis of KOA is not clear, and the mechanism of action of TCM manipulation in the treatment of KOA is still under study. Whether it is the use of holistic, local, or comprehensive therapy, it is still necessary to further clarify its principle of action and better guide clinical practice.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 1","pages":"e9073869"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13309803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148337637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potential Role of Calcium Channels in Pulmonary Hypertension.","authors":"Ping Wu, Dongyang Zhong, Xuqing He, Ying Li, Hui Zhang","doi":"10.1155/bmri/4121036","DOIUrl":"10.1155/bmri/4121036","url":null,"abstract":"<p><p>Pulmonary hypertension (PH) is a severe cardiovascular syndrome characterized by progressively elevated pulmonary arterial pressure and driven pathologically by sustained vasoconstriction and irreversible vascular remodeling. Growing evidence underscores the central role of calcium ion (Ca²⁺) signaling networks in PH pathogenesis, which dynamically regulate vascular smooth muscle cell (VSMC) contraction, proliferation, metabolic reprogramming, and endothelial-mesenchymal transition. This review summarizes recent advances in three key areas: (1) the molecular mechanisms of Ca²⁺ signaling dysregulation in PH, with emphasis on the causal relationship between disrupted calcium homeostasis and pathological vascular remodeling; (2) the multidimensional crosstalk among transmembrane calcium channels-including voltage-dependent calcium channels (VDCCs), store-operated calcium channels (SOCCs), receptor-operated calcium channels (ROCCs), and mechanosensitive channels (MSCs)-and their dynamic roles in driving PH progression through vascular wall cell contraction, proliferation, immune-inflammatory responses, and related pathways; and (3) calcium channel-targeted therapeutic strategies, highlighting recent progress in the development of pharmacological agonists and inhibitors for the management of PH.</p>","PeriodicalId":9007,"journal":{"name":"BioMed Research International","volume":"2026 1","pages":"e4121036"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}