Epidemiological and Clinical Risk Factors for Breast Cancer-Related Lymphedema: A Case-Control Study From Hamadan, Western Iran.

IF 2.9 3区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

BioMed Research International Pub Date : 2026-01-01 DOI:10.1155/bmri/8099570

Soulmaz Rahbar, Hojjat Radinmehr, Mohammad Reza Asadi, Tayebeh Roghani, Azade Tabatabaei, Abdolazim Sedighi Pashaki, Erfan Ayubi

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Abstract

Background: Breast cancer-related lymphedema (BCRL) is one of main issues following treatments in patients with breast cancer (BC). The current study is aimed at evaluating epidemiological and clinical risk factors for BCRL in female patients with BC.

Methods: In a case-control study design from October 2024 to March 2025, female BC patients with and without BCRL were recruited from the Lymphedema Physiotherapy Clinic and the Cancer Therapeutic and Diagnosis Imaging Center in Hamadan, Western Iran. Patient, tumor, and treatment characteristics were gathered via interview and reviewing medical and pathology records.

Results: Overall, 230 patients (127 cases and 103 controls) were included. The multivariable analysis revealed several potential risk factors for BCRL: older age at diagnosis (odds ratio [OR] = 1.05; 95% confidence interval [CI], 1.00, 1.10), urban residency (4.76; 1.20, 20.00), axillary lymph node dissection number of 6-9 compared to ≤ 5 (2.54; 0.99, 6.49), pathology grade of 2 (7.11; 1.47, 34.27) and 3 (6.53; 1.32, 32.32) compared to Grade 1, mastectomy versus lumpectomy (2.86; 1.23, 6.67), receiving chemotherapy (9.55; 1.23, 73.95), and positive progesterone receptor (PR) status (2.56; 1.16, 5.55).

Conclusion: The combination of patient, tumor, and treatment characteristics may be associated with BCRL, highlighting the close monitoring of high-risk patients (older age, high-grade tumors, mastectomy, and PR-positive) in Western Iran.

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乳腺癌相关淋巴水肿的流行病学和临床危险因素：来自伊朗西部哈马丹的病例对照研究

背景：乳腺癌相关淋巴水肿（BCRL）是乳腺癌（BC）患者治疗后的主要问题之一。目前的研究旨在评估女性BC患者BCRL的流行病学和临床危险因素。方法：在2024年10月至2025年3月的病例对照研究设计中，从伊朗西部哈马丹的淋巴水肿物理治疗诊所和癌症治疗和诊断成像中心招募了患有和不患有BCRL的女性BC患者。患者、肿瘤和治疗特征通过访谈和回顾医疗和病理记录收集。结果：共纳入230例患者（127例，103例对照）。多变量分析揭示了BCRL的几个潜在危险因素：诊断时年龄较大（比值比[OR] = 1.05, 95%可信区间[CI]， 1.00, 1.10），城市居住（4.76;1.20,20.00），腋窝淋巴结清扫数为6-9比≤5(2.54;0.99,6.49)，病理分级为2（7.11;1.47,34.27）和3(6.53;1.32,32.32)，病理分级为1级，乳房切除术与乳房肿瘤切除术（2.86;1.23,6.67），接受化疗(9.55；1.23, 73.95)，孕激素受体（PR）阳性状态（2.56;1.16,5.55）。结论：BCRL可能与患者、肿瘤和治疗特点相结合，强调对伊朗西部高危患者（年龄较大、恶性肿瘤、乳房切除术、pr阳性）的密切监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BioMed Research International BIOTECHNOLOGY & APPLIED MICROBIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

6.70

自引率

0.00%

发文量

1942

审稿时长

19 weeks

期刊介绍： BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.