阐明维生素 E 及其类似物在癌症中的免疫治疗潜力:综述》。

IF 2.6 3区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BioMed Research International Pub Date : 2024-10-03 eCollection Date: 2024-01-01 DOI:10.1155/2024/5512422
Nevvin Raaj Morgan, Premdass Ramdas, Saatheeyavaane Bhuvanendran, Ammu Kutty Radhakrishnan
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引用次数: 0

摘要

癌症是一种细胞分裂失控导致的疾病,是人类死亡率的主要原因。由于现有的化疗和放疗方法针对的是癌细胞和健康的分裂细胞,因此需要另一种癌症治疗方法,如癌症免疫疗法。维生素 E 是一种源自植物的脂溶性抗氧化剂,具有多种促进健康的功效,包括抗癌和免疫调节特性。维生素 E 由八种天然异构体组成:生育酚(α、β、δ 和 γ)和生育三烯酚(α、β、δ 和 γ)。虽然最初的研究侧重于 α-生育酚的抗癌特性,但由于其独特的特性和更强的抗癌效果,人们对其他天然形式和改性合成类似物的维生素 E 的兴趣日益浓厚。因此,本综述旨在概述维生素 E 及其类似物在癌症-免疫周期各个阶段的作用,这些作用可用于刺激抗癌免疫反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Delineating the Immunotherapeutic Potential of Vitamin E and Its Analogues in Cancer: A Comprehensive Narrative Review.

Cancer is a disease resulting from uncontrolled cell division, which significantly contributes to human mortality rates. An alternative approach to cancer treatment, such as cancer immunotherapy, is needed as the existing chemotherapy and radiotherapy approaches target the cancer cells and healthy dividing cells. Vitamin E is a plant-derived lipid-soluble antioxidant with numerous health-promoting benefits, including anticancer and immunomodulatory properties. Vitamin E comprises eight natural isoforms: tocopherols (α, β, δ, and γ) and tocotrienols (α, β, δ, and γ). While initial research focused on the anticancer properties of α-tocopherol, there is growing interest in other natural forms and modified synthetic analogues of vitamin E due to their unique properties and enhanced anticancer effects. Hence, this review is aimed at outlining the effect of vitamin E and its analogues at various steps of the cancer-immunity cycle that can be used to stimulate anticancer immune responses.

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来源期刊
BioMed Research International
BioMed Research International BIOTECHNOLOGY & APPLIED MICROBIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
6.70
自引率
0.00%
发文量
1942
审稿时长
19 weeks
期刊介绍: BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
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