ACS Biomaterials Science & Engineering最新文献_第4页

Artificial Bone Materials for Infected Bone Defects: Advances in Antimicrobial Functions. 治疗感染性骨缺损的人工骨材料：抗菌功能的进展。

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2025-03-14 DOI: 10.1021/acsbiomaterials.4c01940

Di Ying, Tianshou Zhang, Manlin Qi, Bing Han, Biao Dong

{"title":"Artificial Bone Materials for Infected Bone Defects: Advances in Antimicrobial Functions.","authors":"Di Ying, Tianshou Zhang, Manlin Qi, Bing Han, Biao Dong","doi":"10.1021/acsbiomaterials.4c01940","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.4c01940","url":null,"abstract":"Infected bone defects, caused by bacterial contamination following disease or injury, result in the partial loss or destruction of bone tissue. Traditional bone transplantation and other clinical approaches often fail to address the therapeutic complexities of these conditions effectively. In recent years, advanced biomaterials have attracted significant attention for their potential to enhance treatment outcomes. This review explores the pathogenic mechanisms underlying infected bone defects, including biofilm formation and bacterial internalization into bone cells, which allow bacteria to evade the host immune system. To control bacterial infection and facilitate bone repair, we focus on antibacterial materials for bone regeneration. A detailed introduction is given on intrinsically antibacterial materials (e.g., metal alloys, oxide materials, carbon-based materials, hydroxyapatite, chitosan, and Sericin). The antibacterial functionality of bone repair materials can be enhanced through strategies such as the incorporation of antimicrobial ions, surface modification, and the combined use of multiple materials to treat infected bone defects. Key innovations discussed include biomaterials that release therapeutic agents, functional contact biomaterials, and bioresponsive materials, which collectively enhance antibacterial efficacy. Research on the clinical translation of antimicrobial bone materials has also facilitated their practical application in infection prevention and bone healing. In conclusion, advancements in biomaterials provide promising pathways for developing more biocompatible, effective, and personalized therapies to reconstruct infected bone defects.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory Microenvironment-Modulated Conductive Hydrogel Promotes Vascularized Bone Regeneration in Infected Bone Defects.

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2025-03-12 DOI: 10.1021/acsbiomaterials.5c00172

Qian Yang, Tianli Wu, Xianghao Wu, Mingxing Ren, Fengyi Liu, Sheng Yang

{"title":"Inflammatory Microenvironment-Modulated Conductive Hydrogel Promotes Vascularized Bone Regeneration in Infected Bone Defects.","authors":"Qian Yang, Tianli Wu, Xianghao Wu, Mingxing Ren, Fengyi Liu, Sheng Yang","doi":"10.1021/acsbiomaterials.5c00172","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.5c00172","url":null,"abstract":"Infected bone defects show a significant reduction in neovascularization during the healing process, primarily due to persistent bacterial infection and immune microenvironmental disorders. Existing treatments are difficult to simultaneously meet the requirements of antibacterial and anti-inflammatory treatments for infected bone defects, which is a key clinical therapeutic challenge that needs to be addressed. In this study, a conductive hydrogel based on copper nanoparticles was developed for controlling bacterial infection and remodeling the immune microenvironment. The hydrogel not only effectively eliminates bacteria that exist in the infected bone defect region but also transmits electrical signals to restore the disordered immune microenvironment. In vitro studies have shown that the hydrogel has excellent biocompatibility and can modulate macrophage polarization by transmitting electrical signals to reduce inflammation and promote neovascularization. In vivo studies further confirmed that the hydrogel scaffold not only rapidly cleared clinical bacterial infections but also significantly induced the formation of vascularized new bone tissue within 4 weeks. This work provides a simple and innovative strategy to fabricate copper-containing conductive hydrogels that show great potential for application in the field of therapeutics for infected bone regeneration.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gadolinium Functionalized Carbon Dot Complexes for Dual-Modal Imaging: Structure, Performance, and Applications.

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2025-03-12 DOI: 10.1021/acsbiomaterials.4c02278

Xin Lv, Lin Chen, Rongrong Guo, Yongzhen Yang, Xuguang Liu, Shiping Yu

{"title":"Gadolinium Functionalized Carbon Dot Complexes for Dual-Modal Imaging: Structure, Performance, and Applications.","authors":"Xin Lv, Lin Chen, Rongrong Guo, Yongzhen Yang, Xuguang Liu, Shiping Yu","doi":"10.1021/acsbiomaterials.4c02278","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.4c02278","url":null,"abstract":"Gadolinium functionalized carbon dot complexes (Gd-CDs) have both the fluorescent properties of carbon dots and the magnetic characteristics of gadolinium ions, exhibiting excellent biocompatibility, high spatial resolution, high sensitivity, and deep tissue penetration in bioimaging. As fluorescence (FL) and magnetic resonance imaging (MRI) probes, Gd-CDs have attracted significant attention in dual-modal biological imaging. This review summarizes recent advances in Gd-CDs, focusing on their structure, optical and magnetic properties, and applications in dual-modal imaging. First, according to the different existing forms of gadolinium in carbon dots, the structures of Gd-CDs are categorized into chelation, electrostatic interaction, and encapsulation. Second, the mechanisms and performances of Gd-CDs in dual-modal imaging are introduced in detail. The reported Gd-CDs have a maximum quantum yield of 69.86%, with a fluorescence emission wavelength reaching up to 625 nm, and the optimum longitudinal and transverse relaxivity rates are 35.39 and 115.6 mM-1 s-1, respectively, showing excellent FL/MRI capacities. Subsequently, the progress in their applications in dual-modal cellular imaging, in vivo imaging, and integrated cancer diagnosis and therapy is reviewed. Finally, the challenges and issues faced by Gd-CDs in their development are summarized, providing new insights for their controlled synthesis and widespread application in the biomedical field of dual-modal imaging.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional Liposomes with Enhanced Stability for Imaging-Guided Cancer Chemodynamic and Photothermal Therapy. 具有增强稳定性的多功能脂质体，可用于成像引导的癌症化学动力疗法和光热疗法

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2025-03-11 DOI: 10.1021/acsbiomaterials.4c02216

Jingyu Zhang, Ren Fang, Ningning Song, Yubao Jin, Meiqi Zhang, Jun Wang, Qixian Peng, He Ren, Yumiao Zhang, Xingyue Yang

{"title":"Multifunctional Liposomes with Enhanced Stability for Imaging-Guided Cancer Chemodynamic and Photothermal Therapy.","authors":"Jingyu Zhang, Ren Fang, Ningning Song, Yubao Jin, Meiqi Zhang, Jun Wang, Qixian Peng, He Ren, Yumiao Zhang, Xingyue Yang","doi":"10.1021/acsbiomaterials.4c02216","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.4c02216","url":null,"abstract":"Improvements in tumor therapy require a combination of strategies where targeted treatment is critical. We developed a new versatile nanoplatform, MA@E, that generates high levels of reactive oxygen species (ROS) with effective photothermal conversions in the removal of tumors. Enhanced stability liposomes were employed as carriers to facilitate the uniform distribution and stable storage of encapsulated gold nanorods (AuNRs) and Mn-MIL-100 metal-organic frameworks, with efficient delivery of MA@E to the cytoplasm. In the targeted phagocytosis of tumor cells, MA@E can effectively deplete the reduced glutathione (GSH) with increased hydroxyl radicals that combine with Mn2+ released from Mn-MIL-100 to trigger Fenton-like reactions, generating ROS that induces cell apoptosis. Exposure to near-infrared (NIR-II) irradiation results in a AuNRs-induced thermogenic effect that expedites the release of Mn2+ and promotes Fenton-like reactions, achieving increased production of •OH. In the murine tumor model, MA@E effectively removed the implanted tumor tissue within 2 days without any obvious toxic effects. This response is attributed to a synergism involving the photothermal capability of AuNRs and ROS chemodynamic treatment. The proposed MA@E provides a new approach to utilizing unstable nanomaterials in effective tumor therapy.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances and Challenges for Biological Materials in Micro/Nanocarrier Synthesis for Bone Infection and Tissue Engineering.

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2025-03-11 DOI: 10.1021/acsbiomaterials.4c02118

Qipeng Xia, Shuyan Zhou, Jingya Zhou, Xia Zhao, Muhammad Saqib Saif, Jianping Wang, Murtaza Hasan, Min Zhao, Qiang Liu

{"title":"Recent Advances and Challenges for Biological Materials in Micro/Nanocarrier Synthesis for Bone Infection and Tissue Engineering.","authors":"Qipeng Xia, Shuyan Zhou, Jingya Zhou, Xia Zhao, Muhammad Saqib Saif, Jianping Wang, Murtaza Hasan, Min Zhao, Qiang Liu","doi":"10.1021/acsbiomaterials.4c02118","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.4c02118","url":null,"abstract":"Roughly 1.71 billion people worldwide suffer from large bone abnormalities, which are the primary cause of disability. Traditional bone grafting procedures have several drawbacks that impair their therapeutic efficacy and restrict their use in clinical settings. A great deal of work has been done to create fresh, more potent strategies. Under these circumstances, a crucial technique for the regeneration of major lesions has emerged: bone tissue engineering (BTE). BTE involves the use of biomaterials that can imitate the natural design of bone. To yet, no biological material has been able to fully meet the parameters of the perfect implantable material, even though several varieties have been created and investigated for bone regeneration. Against this backdrop, researchers have focused a great deal of interest over the past few years on the subject of nanotechnology and the use of nanostructures in regenerative medicine. The ability to create nanoengineered particles that can overcome the current constraints in regenerative strategies─such as decreased cell proliferation and differentiation, insufficient mechanical strength in biological materials, and insufficient production of extrinsic factors required for effective osteogenesis has revolutionized the field of bone and tissue engineering. The effects of nanoparticles on cell characteristics and the application of biological materials for bone regeneration are the main topics of our review, which summarizes the most recent in vitro and in vivo research on the application of nanotechnology in the context of BTE.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143602949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vivo and In Vitro Study of a Multifunctional SF/nHAp Corrosion-Resistant Bio-Coating Prepared on MAO Magnesium Alloy via Ultrasonic Spraying.

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2025-03-11 DOI: 10.1021/acsbiomaterials.4c02405

Chuan Yao Zhai, AnQuan Ma, Wenhao Wang, TianTian Zhu, Liu Huanyu, WeiPeng Lan, TianJiao Yu, Jing Lan, ZhiFeng Wang

{"title":"In Vivo and In Vitro Study of a Multifunctional SF/nHAp Corrosion-Resistant Bio-Coating Prepared on MAO Magnesium Alloy via Ultrasonic Spraying.","authors":"Chuan Yao Zhai, AnQuan Ma, Wenhao Wang, TianTian Zhu, Liu Huanyu, WeiPeng Lan, TianJiao Yu, Jing Lan, ZhiFeng Wang","doi":"10.1021/acsbiomaterials.4c02405","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.4c02405","url":null,"abstract":"Magnesium alloys are often used in bone repair surgeries due to their biodegradability and excellent elastic modulus, making them a promising alternative to traditional nondegradable implants like titanium alloys. However, their rapid degradation rate limits their use as implants in the body. To enhance the corrosion resistance and bioactivity of magnesium alloys, we applied an ultrasonic spray coating on microarc oxidized (MAO) AZ31 magnesium alloy, using a mixture of silk fibroin (SF) and nanohydroxyapatite (nHAp). This SF/nHAp composite embeds directly into the micropores on the MAO-treated surface without additional physical or chemical treatment, forming a stable interlocked coating structure. The effects of different spray parameters on coating adhesion and interface characteristics were investigated, leading to the development of a corrosion-resistant and highly biocompatible composite coating. Further biological evaluations were conducted through subcutaneous implantation, assessing the in vivo degradation of the samples and the surrounding tissue response from multiple perspectives. A novel concept of in vivo tissue-reactive coatings was proposed, suggesting that highly biocompatible coating materials, in the early stages postimplantation, enable surrounding fibrous tissues to closely adhere to the surface, thereby slowing material degradation. As a result, the highly bioactive MAO-SF/nHAp coating significantly enhances the corrosion resistance of magnesium alloys, reduces hydrogen evolution, promotes regeneration of surrounding tissues, and minimizes postimplant inflammation. This approach offers a new strategy to improve the biocompatibility and corrosion resistance of magnesium alloys in vivo, suggesting that the overall evaluation of biodegradable magnesium alloys should focus more on assessing in-body corrosion.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143602945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing Anti-Inflammatory and Regenerative Potential: GelMA Hydrogel Loaded with IL-10 and Kartogenin for Intervertebral Disc Degeneration Therapy.

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2025-03-10 Epub Date: 2025-01-23 DOI: 10.1021/acsbiomaterials.4c01864

Shaofeng Yang, Jinhui Shi, Yusen Qiao, Yun Teng, Xianggu Zhong, Tianyi Wu, Chao Liu, Jun Ge, Huilin Yang, Jun Zou

{"title":"Harnessing Anti-Inflammatory and Regenerative Potential: GelMA Hydrogel Loaded with IL-10 and Kartogenin for Intervertebral Disc Degeneration Therapy.","authors":"Shaofeng Yang, Jinhui Shi, Yusen Qiao, Yun Teng, Xianggu Zhong, Tianyi Wu, Chao Liu, Jun Ge, Huilin Yang, Jun Zou","doi":"10.1021/acsbiomaterials.4c01864","DOIUrl":"10.1021/acsbiomaterials.4c01864","url":null,"abstract":"Intervertebral disc degeneration (IVDD) is a major contributor to chronic back pain and disability, with limited effective therapeutic options. Current treatment options, including conservative management and surgical interventions, often fail to effectively halt disease progression and come with notable side effects. IVDD is characterized by the breakdown of the extracellular matrix (ECM) and the infiltration of inflammatory cells, which exacerbate disc degeneration. This study presents a novel therapeutic strategy aimed at addressing the dual challenges of inflammation and ECM degradation in IVDD. We developed a gelatin methacryloyl (GelMA) hydrogel system loaded with interleukin-10 (IL-10), an anti-inflammatory cytokine, and kartogenin (KGN), a small-molecule compound known for its regenerative properties. The KGN + IL-10@GelMA hydrogel was designed to deliver these agents in a controlled manner directly to the degenerated disc, targeting both the inflammatory microenvironment and the promotion of nucleus pulposus (NP) tissue regeneration. In a puncture-induced IVDD model, this hydrogel system effectively delayed the degenerative progression and facilitated NP regeneration. Our findings suggest that the KGN + IL-10@GelMA hydrogel holds significant potential as a nonsurgical treatment option for IVDD, offering a promising approach to mitigate the progression of IVDD and enhance disc repair.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"1486-1497"},"PeriodicalIF":5.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sericin Electrodes with Self-Adhesive Properties for Biosignaling.

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2025-03-10 Epub Date: 2025-02-04 DOI: 10.1021/acsbiomaterials.4c02234

Davide Vurro, Aris Liboà, Ilenia D'Onofrio, Giuseppe De Giorgio, Silvio Scaravonati, Marco Crepaldi, Alessandro Barcellona, Corrado Sciancalepore, Vardan Galstyan, Daniel Milanese, Mauro Riccò, Pasquale D'Angelo, Giuseppe Tarabella

{"title":"Sericin Electrodes with Self-Adhesive Properties for Biosignaling.","authors":"Davide Vurro, Aris Liboà, Ilenia D'Onofrio, Giuseppe De Giorgio, Silvio Scaravonati, Marco Crepaldi, Alessandro Barcellona, Corrado Sciancalepore, Vardan Galstyan, Daniel Milanese, Mauro Riccò, Pasquale D'Angelo, Giuseppe Tarabella","doi":"10.1021/acsbiomaterials.4c02234","DOIUrl":"10.1021/acsbiomaterials.4c02234","url":null,"abstract":"The combination of green manufacturing approaches and bioinspired materials is growingly emerging in different scenarios, in particular in medicine, where widespread medical devices (MDs) as commercial electrodes for electrophysiology strongly increase the accumulation of solid waste after use. Electrocardiogram (ECG) electrodes exploit electrolytic gels to allow the high-quality recording of heart signals. Beyond their nonrecyclability/nonrecoverability, gel drying also affects the signal quality upon prolonged monitoring of biopotentials. Moreover, gel composition often causes skin reactions. This study aims to address the above limitation by presenting a composite based on the combination of silk sericin (SS) as a structural material, poly(vinyl alcohol) (PVA) as a robustness enhancer, and CaCl2 as a plasticizer. SS/PVA/CaCl2 formulations, optimized in terms of weight content (wt %) of single constituents, result in a biocompatible, biodegradable \"green\" material (free from potentially irritating cross-linking agents) that is, above all, self-adhesive on skin. The best formulation, i.e., SS(4 wt %)/PVA(4 wt %)/CaCl2(20 wt %), in terms of long-lasting skin adhesion (favored by calcium-ion coordination in the presence of environmental/skin humidity) and time-stability of electrode impedance, is used to assemble ECG electrodes showing quality trace recording over longer time scales (up to 6 h) than commercial electrodes. ECG recording is performed using customized electronics coupled to an app for data visualization.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"1776-1791"},"PeriodicalIF":5.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrospun Nanofiber Membrane with Sustained Release of Mogroside V Enhances Alveolar Bone Defect Repair in Diabetic Rats.

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2025-03-10 Epub Date: 2025-02-15 DOI: 10.1021/acsbiomaterials.4c01918

Xiaoxia Zhong, Yiyu Lu, Haiyun Lin, Ziwei Wu, Yicai Luo, Zhimao Ye, Hongbing Liao, Hao Li

{"title":"Electrospun Nanofiber Membrane with Sustained Release of Mogroside V Enhances Alveolar Bone Defect Repair in Diabetic Rats.","authors":"Xiaoxia Zhong, Yiyu Lu, Haiyun Lin, Ziwei Wu, Yicai Luo, Zhimao Ye, Hongbing Liao, Hao Li","doi":"10.1021/acsbiomaterials.4c01918","DOIUrl":"10.1021/acsbiomaterials.4c01918","url":null,"abstract":"The impaired healing of alveolar bone defects in diabetic patients has attracted considerable attention, with Mogroside V (MV) emerging as a promising candidate due to its demonstrated antioxidation, hypoglycemic, and anti-inflammatory properties in patients with diabetes mellitus. To address the limitations of oral MV administration, such as low bioavailability, rapid metabolism, and a short half-life, we developed a nanofiber membrane utilizing electrospinning technology for topical application by preparing membranes using MV, chitosan (CS), nanohydroxyapatite (HA), and poly(vinyl alcohol) (PVA) as raw materials to prolong the effect of MV and enhance bone regeneration in diabetic patients. The MV/HA/PVA/CS exhibited a good fiber diameter, prolonged drug release, and suitable degradation time, along with other favorable properties. In vitro experiments revealed its excellent biocompatibility, effectiveness in promoting osteogenesis, upregulation of osteogenic and anti-inflammatory genes, and concurrent downregulation of pro-inflammatory genes. In vivo evaluations further confirmed its ability to effectively modulate the diabetic microenvironment, reduce bone damage, and facilitate anti-inflammatory effects and alveolar bone regeneration in diabetics. These findings suggest that a nanofiber membrane with sustained release of MV may serve as a promising biomaterial, providing new insights into improving the healing of diabetic alveolar bone defects.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"1660-1674"},"PeriodicalIF":5.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduced Thermal Damage Achieved by High-Conductivity Hydrogel in RF Energy Tissue Welding.

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2025-03-10 Epub Date: 2025-02-22 DOI: 10.1021/acsbiomaterials.4c02292

Wenwen Zhang, Zhongxin Hu, Wanwen Yang, Yilong Chen, Zhaoning Geng, Chengli Song, Lin Mao

{"title":"Reduced Thermal Damage Achieved by High-Conductivity Hydrogel in RF Energy Tissue Welding.","authors":"Wenwen Zhang, Zhongxin Hu, Wanwen Yang, Yilong Chen, Zhaoning Geng, Chengli Song, Lin Mao","doi":"10.1021/acsbiomaterials.4c02292","DOIUrl":"10.1021/acsbiomaterials.4c02292","url":null,"abstract":"Radiofrequency (RF) tissue welding is an innovative tissue anastomosis technique that utilizes bioimpedance to convert electrical energy into thermal energy, enabling the connection and reconstruction of tissues via the denaturation and crosslinking of proteins. However, the high temperatures generated in this process often lead to excessive thermal damage to tissues, thereby adversely impacting cellular activity and impeding tissue repair in practical applications. In this study, we developed a polyacrylamide/alginate (PAAm/Alg) hydrogel with high ionic conductivity (16.8 ± 1.2 S/m) achieved by introducing Ca2+ for the purpose of reducing thermal damage in RF tissue welding. The PAAm/Alg-Ca2+0.5M hydrogel possessed excellent mechanical properties with a stress of 315.6 ± 14.1 kPa and an elongation of 382.7 ± 89.0%. Additionally, the hydrogel exhibited a high water content (83.7 ± 0.3%) and excellent stability of swelling property in water. In addition, the hydrogel extract showed good biocompatibility with no significant adverse effects on cell activity in the cytotoxicity test. At last, we conducted ex vivo experiments to investigate the effectiveness of the hydrogel as a cooling agent during RF tissue welding. The result showed that the maximum temperature was effectively reduced from 137.9 ± 4.7 to 101.8 ± 2.5 °C, while the strength of the anastomotic stoma (12.0 ± 3.2 kPa) was not affected by the intervention of this hydrogel. Histological analysis also revealed that the anastomotic structure of the tissue with hydrogel intervention was more intact than that of the control. Thus, the PAAm/Alg-Ca2+0.5M hydrogel has been demonstrated to function effectively as a cooling agent, offering a new strategy for thermal damage control in RF tissue welding.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"1391-1401"},"PeriodicalIF":5.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0