ACS Biomaterials Science & Engineering最新文献_第5页

Assembly of Recombinant Proteins into β-Sheet Fibrillating Peptide-Driven Supramolecular Hydrogels for Enhanced Diabetic Wound Healing.

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2024-12-09 DOI: 10.1021/acsbiomaterials.4c01723

Zhao Guo, Xing Liu, Yan Xia, Jie Wang, Jiaqi Li, Liping Wang, Yimiao Li, Shuang Jia, Yinan Sun, Jian Feng, Jingxia Huang, Yuxin Dong, Liyao Wang, Xinyu Li

{"title":"Assembly of Recombinant Proteins into β-Sheet Fibrillating Peptide-Driven Supramolecular Hydrogels for Enhanced Diabetic Wound Healing.","authors":"Zhao Guo, Xing Liu, Yan Xia, Jie Wang, Jiaqi Li, Liping Wang, Yimiao Li, Shuang Jia, Yinan Sun, Jian Feng, Jingxia Huang, Yuxin Dong, Liyao Wang, Xinyu Li","doi":"10.1021/acsbiomaterials.4c01723","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.4c01723","url":null,"abstract":"Supramolecular hydrogels offer a noncovalent binding platform that preserves the bioactivity of structural molecules while enhancing their stability, particularly in the context of diabetic wound repair. In this study, we developed protein-peptide-based supramolecular hydrogels by assembling β-sheet fibrillizing peptides (designated Q11) with β-tail fused recombinant proteins. The Q11 peptides have the ability to drive the gradated assembly of N- or C-terminal β-sheet structure (β-tail) fused recombinant proteins. We first investigated the assembly properties of Q11 and assessed its stability under varying pH and temperature conditions by combining Q11 with two β-tail fused fluorescent proteins. The results showed that Q11 enhanced the tolerance of the fluorescent proteins to changes in pH and temperature. Building upon these findings, we designed collagen-like proteins and Sonic Hedgehog-fused recombinant proteins (CLP-Shh) that could be assembled with Q11 to form peptide-protein supramolecular hydrogels. These hydrogels demonstrated the ability to improve cell viability and migration and upregulate key markers of cell growth. Further in vivo studies revealed that the Q11-driven supramolecular hydrogel effectively enhances diabetic wound healing and epidermal regeneration by promoting the expression of epidermal-related proteins and immune factors. This study highlights the potential of supramolecular hydrogels for clinical applications and their promise in the development of biofunctional hydrogels for therapeutic use.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repair of Cartilage Defects Using ATDC5 Cells Treated with BBR Loaded in Chitosan Hydrogel.

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2024-12-09 DOI: 10.1021/acsbiomaterials.4c01645

Yixiao Chen, Guoqing Li, Yufeng Ge, Su Liu, Jian Weng, Jianjing Lin, Ao Xiong, Hui Zeng, Xinbao Wu, Jun Yang, Fei Yu

{"title":"Repair of Cartilage Defects Using ATDC5 Cells Treated with BBR Loaded in Chitosan Hydrogel.","authors":"Yixiao Chen, Guoqing Li, Yufeng Ge, Su Liu, Jian Weng, Jianjing Lin, Ao Xiong, Hui Zeng, Xinbao Wu, Jun Yang, Fei Yu","doi":"10.1021/acsbiomaterials.4c01645","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.4c01645","url":null,"abstract":"In this study, we explore the cartilage defect repair mechanism by phosphocreatine-grafted chitosan hydrogels loaded with berberine-treated ATDC5 cells (CSMP@BBR@ATDC5). Under the optimal concentrations of LPS and BBR ideal conditions, ATDC5 cell toxicity and proliferation were detected with AM/PI and EdU staining. Additionally, qPCR and Western blot were employed to detect the expression of the SIRT1/BMP4 signaling pathway and chondrogenic-related factors in ATDC5 cells. Moreover, BBR-treated ATDC5 was seeded into a phosphocreatine-grafted chitosan hydrogel system. Subsequently, the cartilage defect was established in mice. After 4, 8, and 12 weeks, knee specimens were collected to evaluate the repair of cartilage defects. According to our findings, BBR can increase ATDC5 viability by LPS treatment. Likewise, it upregulates the SIRT1/BMP4 signaling pathway expression and chondrogenic-related factors. Another, it was shown by histological observation that the cartilage defect had been repaired more effectively in the CSMP@BBR@ATDC5 group than in the other groups. Finally, the expressions of chondrogenic-related factors and SIRT1/BMP4 signaling pathway were upregulates in CSMP@BBR@ATDC5 than in other groups. In vitro, BBR protects inflammatory ATDC5 cells and maintains the expression of chondrogenic-related factors. Subsequently, we successfully use CSMP@BBR@ATDC 5 to repair knee cartilage defects in mice.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering Granular Hydrogels without Interparticle Cross-Linking to Support Multicellular Organization. 无颗粒间交联的粒状水凝胶工程，支持多细胞组织。

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2024-12-09 Epub Date: 2024-11-25 DOI: 10.1021/acsbiomaterials.4c01563

Natasha L Claxton, Melissa A Luse, Brant E Isakson, Christopher B Highley

{"title":"Engineering Granular Hydrogels without Interparticle Cross-Linking to Support Multicellular Organization.","authors":"Natasha L Claxton, Melissa A Luse, Brant E Isakson, Christopher B Highley","doi":"10.1021/acsbiomaterials.4c01563","DOIUrl":"10.1021/acsbiomaterials.4c01563","url":null,"abstract":"Advancing three-dimensional (3D) tissue constructs is central to creating in vitro models and engineered tissues that recapitulate biology. Materials that are permissive to cellular behaviors, including proliferation, morphogenesis of multicellular structures, and motility, will support the emergence of tissue structures. Granular hydrogels in which there is no interparticle cross-linking exhibit dynamic properties that may be permissive to such cellular behaviors. However, designing granular hydrogels that lack interparticle cross-linking but support cellular self-organization remains underexplored relative to granular systems stabilized by interparticle cross-linking. In this study, we developed a polyethylene glycol-based granular hydrogel system, with average particle diameters under 40 μm. This granular hydrogel exhibited bulk stress-relaxing behaviors and compatibility with custom microdevices to sustain cell cultures without degradation. The system was studied in conjunction with cocultures of endothelial cells and fibroblasts, known for their spontaneous network formation. Cross-linking, porosity, and cell-adhesive ligands (such as RGD) were manipulated to control system properties. Toward supporting cellular activity, increased porosity was found to enhance the formation of cellular networks, whereas RGD reduced network formation in the system studied. This research highlights the potential of un-cross-linked granular systems to support morphogenetic processes, like vasculogenesis and tissue maturation, offering insights into material design for 3D cell culture systems.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"7594-7605"},"PeriodicalIF":5.4,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innervated Coculture Device to Model Peripheral Nerve-Mediated Fibroblast Activation. 用于模拟外周神经介导的成纤维细胞活化的神经支配共培养装置

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2024-12-09 Epub Date: 2024-11-27 DOI: 10.1021/acsbiomaterials.4c01482

Solsa Cariba, Avika Srivastava, Kendra Bronsema, Sonya Kouthouridis, Boyang Zhang, Samantha L Payne

{"title":"Innervated Coculture Device to Model Peripheral Nerve-Mediated Fibroblast Activation.","authors":"Solsa Cariba, Avika Srivastava, Kendra Bronsema, Sonya Kouthouridis, Boyang Zhang, Samantha L Payne","doi":"10.1021/acsbiomaterials.4c01482","DOIUrl":"10.1021/acsbiomaterials.4c01482","url":null,"abstract":"Cutaneous wound healing is a complex process involving various cellular and molecular interactions, resulting in the formation of a collagen-rich scar with imperfect function and morphology. Dermal fibroblasts are crucial to successful wound healing, migrating to the wound site where they are activated to provide extracellular matrix remodeling and wound closure. Peripheral nerves have been shown to play an important role in wound healing, with loss or damage to these nerves often leading to impaired healing and the formation of chronic nonhealing wounds. Previous research has suggested that sensory nerves secrete trophic factors that can regulate wound healing, including fibroblast activation; however, the direct cell-cell interaction between nerves and fibroblasts has not been extensively studied. To address this knowledge gap, we developed an in vitro co-culture model using a device called the IFlowPlate. This model supports the long-term viability of multiple cell types while allowing for direct contact between sensory nerve cells and dermal fibroblasts. Using the IFlowPlate, we demonstrate that co-culture of dorsal root ganglia with dermal fibroblasts increases fibroblast proliferation, collagen and α-smooth muscle actin expression, and secretion of pro-wound healing factors, suggesting that nerves can promote wound healing by modulating fibroblast activation. The IFlowPlate offers a user-friendly and high-throughput platform to study the in vitro interactions between nerves and a variety of cell types that can be applied to wound healing and other important biological processes.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"7566-7576"},"PeriodicalIF":5.4,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scientific Insights into the Quantum Dots (QDs)-Based Electrochemical Sensors for State-of-the-Art Applications. 基于量子点 (QDs) 的电化学传感器在最新应用中的科学启示。

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2024-12-09 Epub Date: 2024-11-05 DOI: 10.1021/acsbiomaterials.4c01256

Khezina Rafiq, Iqra Sadia, Muhammad Zeeshan Abid, Muhammad Zaryab Waleed, Abdul Rauf, Ejaz Hussain

{"title":"Scientific Insights into the Quantum Dots (QDs)-Based Electrochemical Sensors for State-of-the-Art Applications.","authors":"Khezina Rafiq, Iqra Sadia, Muhammad Zeeshan Abid, Muhammad Zaryab Waleed, Abdul Rauf, Ejaz Hussain","doi":"10.1021/acsbiomaterials.4c01256","DOIUrl":"10.1021/acsbiomaterials.4c01256","url":null,"abstract":"Size-dependent optical and electronic properties are unique characteristics of quantum dots (QDs). A significant advantage is the quantum confinement effect that allows their precise tuning to achieve required characteristics and behavior for the targeted applications. Regarding the aforementioned factors, QDs-based sensors have exhibited dramatic potential for the diverse and advanced applications. For example, QDs-based devices have been potentially utilized for bioimaging, drug delivery, cancer therapy, and environmental remediation. In recent years, use of QDs-based electrochemical sensors have been further extended in other areas like gas sensing, metal ion detection, monitoring of organic pollutants, and detection of radioactive isotopes. Objective of this study is to rationalize the QDs-based electrochemical sensors for state-of-the-art applications. This review article comprehensively illustrates the importance of aforementioned devices along with sources from which QDs devices have been formulated and fabricated. Other distinct features of QDs devices are associated with their extremely high active surfaces, inherent ability of reproducibility, sensitivity, and selectivity for the targeted analyte detection. In this review, major categories of QD materials along with justification of their key roles in electrochemical devices have been demonstrated and discussed. All categories have been evaluated with special emphasis on the advantages and drawbacks/challenges associated with QD materials. However, in the interests of readers and researchers, recent improvements also have been included and discussed. On the evaluation, it has been concluded that despite significant challenges, QDs-based electrochemical sensors exhibit excellent performances for state-of-the-art and targeted applications.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"7268-7313"},"PeriodicalIF":5.4,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142580905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet Membrane-Camouflaged Copper Doped CaO₂ Biomimetic Nanomedicines for Breast Cancer Combination Treatment. 用于乳腺癌联合治疗的血小板膜伪装铜掺杂 CaO2 生物仿生纳米药物。

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2024-12-09 Epub Date: 2024-11-04 DOI: 10.1021/acsbiomaterials.4c01362

Luping Ren, Junhao Zhang, Lei Nie, Armin Shavandi, Khaydar E Yunusov, Uladzislau E Aharodnikau, Sergey O Solomevich, Yanfang Sun, Guohua Jiang

{"title":"Platelet Membrane-Camouflaged Copper Doped CaO2 Biomimetic Nanomedicines for Breast Cancer Combination Treatment.","authors":"Luping Ren, Junhao Zhang, Lei Nie, Armin Shavandi, Khaydar E Yunusov, Uladzislau E Aharodnikau, Sergey O Solomevich, Yanfang Sun, Guohua Jiang","doi":"10.1021/acsbiomaterials.4c01362","DOIUrl":"10.1021/acsbiomaterials.4c01362","url":null,"abstract":"Breast cancer (BC) is the most frequently diagnosed cancer in women worldwide. Chemodynamic therapy (CDT), photothermal therapy (PTT), and ion interference therapy (IIT), used in combination, represent a common treatment. In this study, platelet membrane-camouflaged copper-doped CaO2 biomimetic nanomedicines have been developed for breast cancer treatments. Copper-doped CaO2 nanoparticles were first coated by polydopamine (PDA) and subsequently camouflaged by platelet membrane (PM) to form platelet membrane-camouflaged copper doped CaO2 biomimetic nanomedicines (Cu-CaO2@PDA/PM). The as-fabricated Cu-CaO2@PDA/PM multifunctional nanomedicines could decompose within the tumor microenvironment to release Ca2+ for ion interference therapy, and the generated H2O2 could perform a Fenton-like reaction with the assistance of loaded copper ions to produce ·OH, thus realizing chemodynamic therapy. In addition, the copper ions could also consume glutathione and weaken its ability to scavenge reactive oxygen species, which was conducive to amplifying the effect of oxidative stress. The coating of the polydopamine layer could achieve local hyperthermia of the tumor site, and the surface modification of the platelet membrane could enhance the targeting and biocompatibility of nanomedicines. In vivo and in vitro tests demonstrated that the developed Cu-CaO2@PDA/PM biomimetic nanomedicines offer a promising biomimetic nanoplatform for efficient multimodal combination therapy for breast cancer.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"7492-7506"},"PeriodicalIF":5.4,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Micelle-like Nanoparticles for Drug Delivery and Magnetically Enhanced Tumor Chemotherapy. 用于给药和磁增强肿瘤化疗的胶束状纳米粒子。

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2024-12-09 Epub Date: 2024-11-22 DOI: 10.1021/acsbiomaterials.4c01897

Liqin Xie, Xirui Zuo, Beilei Wang, Dan Li, Wenke Chang, Shenglu Ji, Dan Ding

{"title":"Micelle-like Nanoparticles for Drug Delivery and Magnetically Enhanced Tumor Chemotherapy.","authors":"Liqin Xie, Xirui Zuo, Beilei Wang, Dan Li, Wenke Chang, Shenglu Ji, Dan Ding","doi":"10.1021/acsbiomaterials.4c01897","DOIUrl":"10.1021/acsbiomaterials.4c01897","url":null,"abstract":"Using the coordination bonds between transition metal atoms and electron-rich functional groups, we synthesized two kinds of micelle-like nanoparticles. Using magnetic Fe3O4 as the core, poly(methyl methacrylate) (PMMA) and poly(acrylic acid) (PAA) brushes were grafted via activators regenerated by electron transfer for atom transfer radical polymerization (ARGET-ATRP), which formed micelle-like magnetic nanoparticles Fe3O4/PAA-PMMA with a hydrophobic outer layer and Fe3O4/PMMA-PAA with a hydrophilic outer layer. Both the micelle-like nanoparticles had amphiphilic properties and can be used to load hydrophilic or hydrophobic drugs. Even loaded with hydrophobic drugs, the micelle-like nanoparticles can still be dispersed in aqueous solution, and Fe3O4/PAA-PMMA had a higher loading content. As the drug carrier, these two micelle-like nanoparticles can be used for magnetically targeted drug delivery and magnetic resonance imaging due to superparamagnetic Fe3O4. In addition, due to the magnetic retention effect, the drug-loaded micelle-like nanoparticles remained at the tumor site, increasing the local drug concentration. At the same time, the drug-loaded micelle-like nanoparticles generated a magnetocaloric effect under the alternating magnetic field, which not only killed tumor cells by magnetic hyperthermia but also promoted the rapid release of drugs at the tumor site. In general, magnetically enhanced chemotherapy showed the best therapeutic effect on tumors.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"7527-7538"},"PeriodicalIF":5.4,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Biocompatible Ti-MOF@hydroxyapatite Composite Boosted with Gentamicin for Postoperative Infection Control. 新型生物相容性 Ti-MOF@hydroxyapatite 复合材料添加庆大霉素用于术后感染控制

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2024-12-09 Epub Date: 2024-11-26 DOI: 10.1021/acsbiomaterials.4c01230

Weronika Bodylska, Adam Junka, Malwina Brożyna, Michał Bartmański, Renata Gadzała-Kopciuch, Anna Jaromin, Jorge A R Navarro, Anna Lukowiak, Marzena Fandzloch

{"title":"New Biocompatible Ti-MOF@hydroxyapatite Composite Boosted with Gentamicin for Postoperative Infection Control.","authors":"Weronika Bodylska, Adam Junka, Malwina Brożyna, Michał Bartmański, Renata Gadzała-Kopciuch, Anna Jaromin, Jorge A R Navarro, Anna Lukowiak, Marzena Fandzloch","doi":"10.1021/acsbiomaterials.4c01230","DOIUrl":"10.1021/acsbiomaterials.4c01230","url":null,"abstract":"The standard clinical management of osteomyelitis involves prolonged antibiotic therapy, which frequently necessitates the excision of infected tissues. However, the efficacy of such treatments is increasingly compromised by the rise of antibiotic-resistant pathogens, underscoring an urgent need for innovative approaches. This study introduces a novel composite material designed to offer dual functionality: robust antimicrobial activity and promotion of bone regeneration. The composite integrates biocompatible hydroxyapatite nanoparticles (HA) with a titanium(IV)-metal-organic framework, MIL-125(Ti)-NH2, impregnated with gentamicin (GM). The solvothermally synthesized MIL-125-NH2@HA composite demonstrates high cytocompatibility, as evidenced by assays using osteoblasts (U2-OS) and fibroblasts (L929), alongside an absence of hemolytic activity at concentrations of up to 1000 μg/mL. Importantly, the introduction of GM into the composite significantly amplifies its antibacterial efficacy against Staphylococcus aureus and Pseudomonas aeruginosa. Additionally, nanoindentation assessments reveal enhanced mechanical properties of the MIL-125-NH2@HA composite, indicating the superior elastic performance relative to unmodified HA. The findings of this research are poised to generate significant interest in the development of metal-organic framework (MOF)-based composites for antimicrobial implant applications, presenting a promising avenue for addressing the challenges posed by antibiotic resistance in bone infections.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"7555-7565"},"PeriodicalIF":5.4,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced Preparation Methods and Biomedical Applications of Single-Atom Nanozymes. 单原子纳米酶的先进制备方法和生物医学应用。

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2024-12-09 Epub Date: 2024-11-13 DOI: 10.1021/acsbiomaterials.4c01530

Chun-Nan Zhu, Xin Chen, Yong-Qiang Xu, Fei Wang, Dong-Yun Zheng, Chao Liu, Xue-Hao Zhang, Yu Yi, Dong-Bing Cheng

引用次数: 0

Hydrogels in Alveolar Bone Regeneration. 水凝胶在牙槽骨再生中的应用

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2024-12-09 Epub Date: 2024-11-21 DOI: 10.1021/acsbiomaterials.4c01359

Zhuoran Xu, Junyi Wang, Liheng Gao, Wenjie Zhang

引用次数: 0