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IF 5.4 2区 医学
ACS Biomaterials Science & Engineering Pub Date : 2025-06-09
Mingming Hao, Botao Liu, Jiaqi Zhong, Yujiong Chen, Xiaodong Hu, Zhewei Zhang, Jianping Chen, Han Yu, Jiangfang Lian, Yabin Zhu, Chunhai Ke*, Jingyun Ma* and Zhaoxiang Peng*, 
{"title":"","authors":"Mingming Hao, Botao Liu, Jiaqi Zhong, Yujiong Chen, Xiaodong Hu, Zhewei Zhang, Jianping Chen, Han Yu, Jiangfang Lian, Yabin Zhu, Chunhai Ke*, Jingyun Ma* and Zhaoxiang Peng*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.4c01769","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144432328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 5.4 2区 医学
ACS Biomaterials Science & Engineering Pub Date : 2025-06-09
Wei Zhang, Kyoko Fukazawa, Atsushi Mahara, Hue Thi Le, Raghav Soni and Tetsuji Yamaoka*, 
{"title":"","authors":"Wei Zhang, Kyoko Fukazawa, Atsushi Mahara, Hue Thi Le, Raghav Soni and Tetsuji Yamaoka*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.5c00236","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144373881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiome Metabolite-Incorporated Lipid Nanoparticles Augment CD8+ T Cell Memory Potential and Immunity for mRNA Cancer Vaccines. 微生物代谢物结合的脂质纳米颗粒增强CD8+ T细胞记忆潜能和mRNA癌症疫苗的免疫力。
IF 5.4 2区 医学
ACS Biomaterials Science & Engineering Pub Date : 2025-06-09 DOI: 10.1021/acsbiomaterials.5c00738
Seok-Beom Yong, Minki Ha, Sungchan Cho
{"title":"Microbiome Metabolite-Incorporated Lipid Nanoparticles Augment CD8<sup>+</sup> T Cell Memory Potential and Immunity for mRNA Cancer Vaccines.","authors":"Seok-Beom Yong, Minki Ha, Sungchan Cho","doi":"10.1021/acsbiomaterials.5c00738","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.5c00738","url":null,"abstract":"<p><p>Recently, mRNA/lipid nanoparticle (LNP)-based vaccines have been successfully applied to prevent infectious diseases, and several types of neoantigen-encoding mRNA cancer vaccines are currently under clinical trials. While mRNA vaccines effectively induce adaptive immune responses to antigens, mRNA vaccine-induced immunity is shortly maintained, and the longevity of the immune memory, especially improving the CD8<sup>+</sup> T cell memory potential, could be even more important. Previously, microbiome metabolites have shown T cell memory potential-augmenting effects via regulating the immunometabolism. Herein, we develop microbiome metabolite-incorporated LNPs (mmi-LNPs) and evaluate their potential to enhance T cell memory responses following mRNA vaccination. In various ionizable LNP formulations, mmi-LNPs elicited more stem cell-like memory T cells (T-SCMs) and augmented central and effector memory T cell responses, which indicates the general applicability of mmi-LNPs. Notably, butyrate-incorporated mmi-LNP exhibited the strongest effects. In conclusion, we suggest microbiome metabolite-incorporated LNP as a next-generation delivery vehicle for mRNA vaccines.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing Microfluidic Channel Design with Tilted Rectangular Baffles for Enhanced mRNA-Lipid Nanoparticle Preparation. 倾斜矩形挡板优化微流控通道设计，增强mrna -脂质纳米颗粒制备。
IF 5.4 2区 医学
ACS Biomaterials Science & Engineering Pub Date : 2025-06-09 Epub Date: 2025-05-21 DOI: 10.1021/acsbiomaterials.4c02373
Mingzhi Yu, Dongsheng Liu, Pranay Shah, Bei Qiu, Allen Mathew, Liang Yao, Tianyu Guan, Hengji Cong, Nan Zhang
{"title":"Optimizing Microfluidic Channel Design with Tilted Rectangular Baffles for Enhanced mRNA-Lipid Nanoparticle Preparation.","authors":"Mingzhi Yu, Dongsheng Liu, Pranay Shah, Bei Qiu, Allen Mathew, Liang Yao, Tianyu Guan, Hengji Cong, Nan Zhang","doi":"10.1021/acsbiomaterials.4c02373","DOIUrl":"10.1021/acsbiomaterials.4c02373","url":null,"abstract":"<p><p>RNA therapeutics represent a pivotal advancement in contemporary medicine, pioneering innovative treatments in oncology and vaccine production. The inherent instability of RNA and its delivery challenges necessitate the use of lipid-based nanoparticles as crucial transport vehicles. This research focuses on the design, simulation, and optimization of various microfluidic channel configurations for fabricating poly(dimethylsiloxane) (PDMS) microfluidic chips, aimed at producing lipid nanoparticles (LNPs) encapsulating green fluorescent protein mRNA (GFP mRNA). Aiming for high mixing efficiency and acceptable pressure drop suitable for scale-up, we designed and improved multiple microfluidic channels featuring flow focusing and diverse tilted rectangular baffle structures via computational fluid dynamics (CFD). Simulation results indicated that baffle angles ranging from 70 to 90° exhibited similar mixing efficiencies at different total flow rates, with pressure drops increasing alongside the baffle angle. Additionally, increasing the baffle length at a fixed angle of 70° not only improved mixing efficiency but also increased the pressure drop. To validate these findings, PDMS microfluidic chips were fabricated for all designs to prepare empty LNPs. The baffle structure with a 70° angle and 150 μm length was identified as the best configuration based on both simulation and experimental results. This optimal design was then used to prepare LNPs with varying GFP mRNA concentrations, demonstrating that an N/P ratio of 5.6 yielded the highest transfection efficiency from <i>in vitro</i> experiments. This work not only advances the production of lipid-based nanoparticles through microfluidics but also provides a scalable and reproducible method that can potentially enhance the clinical translation of RNA therapeutics.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"3762-3772"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 5.4 2区 医学
ACS Biomaterials Science & Engineering Pub Date : 2025-06-09
Sara Metwally*, Justyna Śmiałek-Bartyzel, Joanna Pabijan and Małgorzata Lekka*, 
{"title":"","authors":"Sara Metwally*,&nbsp;Justyna Śmiałek-Bartyzel,&nbsp;Joanna Pabijan and Małgorzata Lekka*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.5c00136","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144358017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 5.4 2区 医学
ACS Biomaterials Science & Engineering Pub Date : 2025-06-09
Mohammad Hamrangsekachaee, Yu Chen, Emily R. Tressler, Lucas McCauley, Nicholas R. O’Hare, Chinedu C. Okorafor, Sidi A. Bencherif* and Eno E. Ebong*, 
{"title":"","authors":"Mohammad Hamrangsekachaee,&nbsp;Yu Chen,&nbsp;Emily R. Tressler,&nbsp;Lucas McCauley,&nbsp;Nicholas R. O’Hare,&nbsp;Chinedu C. Okorafor,&nbsp;Sidi A. Bencherif* and Eno E. Ebong*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.4c02401","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144358018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 5.4 2区 医学
ACS Biomaterials Science & Engineering Pub Date : 2025-06-09
Jang Woo Yang, Taehee Yoon, Haram Kim, Kye Il Joo and Hyung Joon Cha*, 
{"title":"","authors":"Jang Woo Yang,&nbsp;Taehee Yoon,&nbsp;Haram Kim,&nbsp;Kye Il Joo and Hyung Joon Cha*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.5c00390","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144358021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 5.4 2区 医学
ACS Biomaterials Science & Engineering Pub Date : 2025-06-09
Meiqi Zhao, Yuqi Zhao, Guangwen Li, Li Zhang, Haochen Wang, Yonglong Hong, Weihua Yu*, Wen Song* and Yumei Zhang*, 
{"title":"","authors":"Meiqi Zhao,&nbsp;Yuqi Zhao,&nbsp;Guangwen Li,&nbsp;Li Zhang,&nbsp;Haochen Wang,&nbsp;Yonglong Hong,&nbsp;Weihua Yu*,&nbsp;Wen Song* and Yumei Zhang*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.4c02357","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144358022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 5.4 2区 医学
ACS Biomaterials Science & Engineering Pub Date : 2025-06-09
Ting Hua, Rui Wan, Chengcheng Chai, Ran Li, Shuo Wang, Yi Tang, Tianzi Zhang* and Hong Wu*, 
{"title":"","authors":"Ting Hua,&nbsp;Rui Wan,&nbsp;Chengcheng Chai,&nbsp;Ran Li,&nbsp;Shuo Wang,&nbsp;Yi Tang,&nbsp;Tianzi Zhang* and Hong Wu*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.5c00422","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144358023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 5.4 2区 医学
ACS Biomaterials Science & Engineering Pub Date : 2025-06-09
Lulu Du, Liya Zhang, Shengzhe Bao, Fangsu Yan, Wenwei Jiang, Hui Wang* and Chuanming Dong*, 
{"title":"","authors":"Lulu Du,&nbsp;Liya Zhang,&nbsp;Shengzhe Bao,&nbsp;Fangsu Yan,&nbsp;Wenwei Jiang,&nbsp;Hui Wang* and Chuanming Dong*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.5c00615","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144373857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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