ACS Biomaterials Science & Engineering最新文献

{"title":"Correction to “Forming Single-Cell-Derived Colon Cancer Organoid Arrays on a Microfluidic Chip for High Throughput Tumor Heterogeneity Analysis”","authors":"Zihe Chen, Jueming Chen, Dongguo Lin, Hui Kang, Yanzhang Luo, Xiaogang Wang, Lihui Wang* and Dayu Liu*, ","doi":"10.1021/acsbiomaterials.5c0072410.1021/acsbiomaterials.5c00724","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.5c00724https://doi.org/10.1021/acsbiomaterials.5c00724","url":null,"abstract":"","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 5","pages":"3083 3083"},"PeriodicalIF":5.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143934199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zein/ZnO-Modified 3D-Printed PCL/Sphene Scaffolds with Improved Bacterial Inhibition and Osteoblast Activity for Bone Regeneration Applications","authors":"Monireh Kouhi*,&nbsp;Mohammad Khodaei,&nbsp;Bahareh Behrouznejad,&nbsp;Omid Savabi and Mahdi Bodaghi,&nbsp;","doi":"10.1021/acsbiomaterials.4c0219310.1021/acsbiomaterials.4c02193","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.4c02193https://doi.org/10.1021/acsbiomaterials.4c02193","url":null,"abstract":"<p >3D printing offers a significant advantage in creating bioengineering scaffolds for patient-specific treatments of bony defects. In this study, a 3D-printed polycaprolactone (PCL)/sphene (SP, CaTiSiO5) scaffold coated with zein/ZnO was fabricated to provide a suitable environment for bone regeneration. SP nanoparticles were synthesized using a mechanochemical method and characterized by SEM-EDS, FTIR, and XRD. 0–30 wt % of prepared SP nanoparticles was used to fabricate 3D-printed PCL-based scaffolds. Incorporation of SP into PCL scaffolds (up to 20 wt %) significantly increased compressive strength (from 37.5 to 65.2 MPa) and modulus (from 0.33 to 0.63 MPa). <i>In vitro</i> bioactivity evaluation in simulated body fluid demonstrated the apatite formation ability of PCL/SP scaffolds, as confirmed by SEM-EDS analysis. Compared to PCL/SP, the zein/ZnO-modified scaffold showed increased surface hydrophilicity and significantly higher values of bactericidal potency against <i>S. aureus</i> and <i>E. coli</i>. Additionally, MTT assay, cell attachment, and alkaline phosphatase activity revealed that zein and ZnO coexistence on PCL/SP scaffolds resulted in significantly higher cell proliferation, improved cell adhesion, and enhanced osteogenic differentiation of MG-63 cells compared to unmodified samples. Overall, zein/ZnO-modified 3D-printed PCL/SP nanocomposite scaffolds with desirable physicochemical, mechanical, and biological characteristics can serve as superior platforms for bone regeneration applications.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 5","pages":"2898–2909 2898–2909"},"PeriodicalIF":5.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143933790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Assembly Oligomeric Anthocyanin-Based Core–Shell Structure of Nanoparticles Enhances the Delivery and Efficacy of Berberine in Osteoarthritis","authors":"Yao Huang,&nbsp;Xie Wang,&nbsp;Huikun Chen,&nbsp;Yu Wu,&nbsp;Lei Lv,&nbsp;Feilong Chen,&nbsp;Hanqi Lei* and Chengyuan Xing*,&nbsp;","doi":"10.1021/acsbiomaterials.5c0003710.1021/acsbiomaterials.5c00037","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.5c00037https://doi.org/10.1021/acsbiomaterials.5c00037","url":null,"abstract":"<p >Osteoarthritis (OA) is a degenerative joint disease that significantly contributes to functional disability, primarily due to inflammation and cell apoptosis. Berberine (BBR) has demonstrated notable anti-inflammatory and antiapoptotic effects in the treatment of OA. However, despite its promising pharmacological properties, the naturally occurring hydrophobic properties and limited solubility in water restrict the efficacy of BBR. Therefore, excipients are required to modify BBR. Oligomeric proanthocyanidins (OPAs) are dimers, trimers, and tetramers of proanthocyanidins (PAs). The unique interface properties of the OPAs underscore their potential as drug carriers. OPAs as natural carriers enhance medication effectiveness and significantly reduce the incidence of side effects. Herein, we developed natural self-assembled nanoparticles between BBR and the OPAs (BBR-OPAs NPs). By adopting the unification of medicines and excipients, the OPAs-based drug delivery system serves as an effective carrier and exerts therapeutic effects in OA treatment. The formation of BBR-OPAs NPs has been core–shell structure, as confirmed by transmission electron microscopy (TEM), 2D NOESY spectroscopy, and molecular dynamics (MD) simulation. The BBR-OPAs NPs exhibited good long-acting release capability due to their strong noncovalent interactions, making them competitive candidates for treating OA. Microcomputed tomography (micro-CT) scanning and histological evaluation further confirmed the efficacy of BBR-OPAs NPs in treating OA. In vivo assessments demonstrated that BBR-OPAs NPs inhibited inflammation and apoptosis, thereby preventing the progression of OA. Furthermore, treatment with BBR-OPAs NPs can inhibit synovial inflammation and protect chondrocytes. OPAs show broad prospects as drug delivery carriers and exhibit great potential in the treatment of OA.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 5","pages":"2739–2752 2739–2752"},"PeriodicalIF":5.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143933654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Powered Oxygen Microbubble Generator for Decontamination of Anaerobic Biofilm-Fouled Bioimplants","authors":"Eun-Hyuk Lee,&nbsp;Hyunsub Kim,&nbsp;Joo Hun Lee,&nbsp;Youngjoon Kim,&nbsp;Ho-Beom Kwon,&nbsp;Young-Jun Lim,&nbsp;Hyunjoon Kong*,&nbsp;Sang-woo Lee* and Myung-Joo Kim*,&nbsp;","doi":"10.1021/acsbiomaterials.5c0030310.1021/acsbiomaterials.5c00303","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.5c00303https://doi.org/10.1021/acsbiomaterials.5c00303","url":null,"abstract":"<p >Biomedical devices often feature a microgap: confined, minuscule spaces that foster bacterial infiltration and biofilm formation. For instance, peri-implantitis with prevalence rates of 4.7–45% at the patient level is a major complication driven by biofilm infections, characterized by chronic inflammation and implant failure. Anaerobic biofilm residing within the microgap serves as a major source of the peri-implantitis, but tools that remove the biofilm are lacking. Therefore, this study presents a novel preventive strategy employing <b>s</b>elf-powered <b>m</b>icrobubbler (SM) for targeted decontamination of micrographs in dental implants. SMs are assembled by doping diatoms with MnO₂ nanosheets. These particles are activated to generate O₂ microbubbles in H₂O₂ solution via catalase-mimetic activity and can penetrate the biofilm structures. The resulting oxygen bubbles induce effective mechanical disruption and oxygenation within biofilm-mimicking gelatin hydrogels and <i>Porphyromonas gingivalis</i> biofilms found in the peri-implantitis-affected implants. Such biofilm removal from the microgap restored mechanical stability at implant abutment-fixture connections and reduced bacterial leakage. Multispecies biofilms from patient-derived implants were similarly decontaminated with the mixture of SM-H₂O₂ outperforming conventional antiseptics like 0.2% chlorhexidine and 3% H₂O₂ alone. This innovative approach extends beyond dental implants to address biofilm-associated challenges in various biomedical devices with microgap vulnerabilities. Overall, SM-based treatments will offer an efficient and nondamaging solution to enhance the sterility and longevity of various bioimplants with intricated and confined structure.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 5","pages":"3019–3030 3019–3030"},"PeriodicalIF":5.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsbiomaterials.5c00303","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143933887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Renal Protection in Acute Kidney Injury with ROS-Activated Nanoparticles Targeting Oxidative Stress and Inflammation","authors":"Tianyu Lan,&nbsp;Mei Li,&nbsp;Xiuheng Luo,&nbsp;Haijun Du,&nbsp;Xin Lu,&nbsp;Huijuan Mao*,&nbsp;Honglei Guo* and Qianqian Guo*,&nbsp;","doi":"10.1021/acsbiomaterials.4c0191710.1021/acsbiomaterials.4c01917","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.4c01917https://doi.org/10.1021/acsbiomaterials.4c01917","url":null,"abstract":"<p >Acute kidney injury (AKI) is often associated with oxidative stress, which leads to a range of pathological changes, including inflammation and cell apoptosis. These mechanisms highlight the crucial role of eliminating ROS in the pathogenesis of AKI. This study presented a ROS-activated drug delivery system, NPS_PBA@Hib, designed for the targeted delivery of the anti-inflammatory and antioxidant drug hibifolin (Hib) to the kidneys, marking its inaugural application in AKI therapy. The drug loading of Hib was up to be 15% by conversely binding with the phenylboronic acid parts in the nanoparticles. NPS_PBA@Hib increased cellular uptake of drugs in HK-2 cells and reduced oxidative stress-induced damage by scavenging ROS. The nanoparticles notably extended the retention of Hib in AKI kidneys when compared to healthy kidneys, leading to heightened accumulation in the renal tubules. NPS_PBA@Hib demonstrated Hib’s reno-protective effects by reducing oxidative stress and inflammation. In essence, this research serves as the primary confirmation of Hib’s efficacy in inhibiting NLRP3 signaling pathway for the AKI treatment. The findings suggest that NPS_PBA@Hib nanoparticles are effective in treating AKI, highlighting the promising potential of utilizing Hib as a natural antioxidant nanoplatform for AKI, as well as other ROS-related diseases.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 5","pages":"2713–2726 2713–2726"},"PeriodicalIF":5.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143934037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Azido-Incorporated Bombyx mori Silk Fibroin as a Drug Carrier Material","authors":"Yaxi Tian,&nbsp; and ,&nbsp;Hidetoshi Teramoto*,&nbsp;","doi":"10.1021/acsbiomaterials.5c0023210.1021/acsbiomaterials.5c00232","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.5c00232https://doi.org/10.1021/acsbiomaterials.5c00232","url":null,"abstract":"<p >Silk fibroin, a natural polymer derived from the domesticated silkworm, <i>Bombyx mori</i>, exhibits remarkable tensile toughness, broad biocompatibility, and biodegradability. We previously developed azido-incorporated silk fibroin (<i>AzidoSilk</i>) using genetic code expansion. <i>AzidoSilk</i> contains synthetic azido groups that can be selectively attached to any functional molecule in a bioorthogonal manner through click chemistry. Click chemistry provides high yields and minimal byproducts. In this study, <i>AzidoSilk</i> was characterized as a drug carrier material for on-demand drug delivery systems (DDS) because effective drug loading and controllable release by external stimuli can be achieved with <i>AzidoSilk</i> via click chemistry modifications. Fluorescent drug models were immobilized on <i>AzidoSilk</i> film and woven fabric via a UV-sensitive bifunctional linker using click chemistry. Azido-selective immobilization of the drug models was confirmed, and upon irradiation with 365 nm UV light, the drug models were gradually released from the <i>AzidoSilk</i> materials in a time-dependent manner. In another model, kanamycin was immobilized on <i>AzidoSilk</i> fabric via the same UV-sensitive linker, and its antibacterial activity against <i>Staphylococcus aureus</i> was tested. PBS extracts from kanamycin-immobilized <i>AzidoSilk</i> fabrics after UV irradiation showed significant antibacterial activity against <i>S. aureus</i>. These results demonstrate that <i>AzidoSilk</i> can be used as a drug carrier material for on-demand DDS. In this system, changes in linker design can expand the range of external stimuli usable for drug release, depending on the application. <i>AzidoSilk</i> has broadened the scope of chemical modification of silk fibroin to achieve simpler and more reliable drug delivery.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 5","pages":"2783–2791 2783–2791"},"PeriodicalIF":5.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143933872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of Multiscale, Multidirectional Orientated Collagen Hydrogels with Guided Cell Alignment Using Fluidics and a Three-Dimensional Printing","authors":"Mizuki Iijima,&nbsp;Mitsuki Sato,&nbsp;Hoshi Wakabayashi,&nbsp;Kaori Kojima,&nbsp;Kanata Togashi,&nbsp;Shogo Oishi,&nbsp;Takumi Misu,&nbsp;Masaru Mukai,&nbsp;Hiroki Miyajima,&nbsp;Shoji Maruo and Kazutoshi Iijima*,&nbsp;","doi":"10.1021/acsbiomaterials.4c0215610.1021/acsbiomaterials.4c02156","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.4c02156https://doi.org/10.1021/acsbiomaterials.4c02156","url":null,"abstract":"<p >Various tissues have oriented collagen structures that confer mechanical strength and stability. However, creating models that precisely mimic the size and direction of these tissues remains challenging. In the present study, we developed a collagen tissue with multiscale and multidirectional controlled orientation using fluidic devices prepared using three-dimensional (3D) printing technology. Two types of fluidic channels were fabricated: a one-directional “horizontal orientation model” and vertical protrusions added to create a two-directional “vertical/horizontal orientation model”. A type I collagen solution, mixed with or without cells, was introduced into the fluidic channel and gelled. As a result, in the horizontal orientation model, collagen fibrils and fibers were oriented by the flow. Both the fibroblasts and stem cells were aligned parallel to the flow along the collagen structure. In the vertical/horizontal orientation model, both the horizontal and vertical parts confirmed the orientation of collagen fibrils, fibers, and fibroblasts in both directions. Observation of the model at the nanoscale level using scanning electron microscopy (SEM) can explain the collagen orientation mechanism at the molecular and fibril levels. Prior to full gelation, collagen molecules and fibrils align parallel to the flow owing to the influence of flow and channel wall effects. This wall effect, starting from the outer channel wall, creates a gelated collagen “wall” toward the inside of the channel. Collagen fibrils aggregate into collagen fibers. In our experiments focusing on collagen contraction, the cell orientation was also described. As cells proliferate in response to the contact guidance of collagen fibrils and fiber orientation, focal adhesions and F-actin are activated and organize anisotropic traction forces that, in turn, drive cell orientation. Therefore, our method enables the customization of models with the desired tissue-specific orientations, thereby advancing future possibilities in tissue engineering.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 5","pages":"2875–2887 2875–2887"},"PeriodicalIF":5.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsbiomaterials.4c02156","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143933881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organoids in Dynamic Culture: Microfluidics and 3D Printing Technologies.","authors":"Xin Su, Mingqi Wang, Ruqiang Yuan, Lina Guo, Yinhe Han, Chun Huang, Ang Li, David L Kaplan, Xiuli Wang","doi":"10.1021/acsbiomaterials.4c02245","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.4c02245","url":null,"abstract":"<p><p>With the rapid advancement of biomaterials and tissue engineering technologies, organoid research and its applications have made significant strides. Organoids are increasingly utilized in pharmacology, regenerative medicine, and precision clinical medicine. Current trends in organoid research are moving toward multifunctional composite three-dimensional cultivation and dynamic cultivation strategies. Key technologies driving this evolution, including 3D printing and microfluidics, continue to impact new areas of discovery and clinical relevance. This review provides a systematic overview of these emerging trends, discussing the strengths and limitations of these critical technologies and offering insight and research directions for professionals working in the organoid field.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biofabrication of HepG2 Cells-Laden 3D Structures Using Nanocellulose-Reinforced Gelatin-Based Hydrogel Bioinks: Materials Characterization, Cell Viability Assessment, and Metabolomic Analysis","authors":"Nicole S. Lameirinhas,&nbsp;Maria C. Teixeira,&nbsp;João P. F. Carvalho,&nbsp;Bruno F. A. Valente,&nbsp;Jorge L. Luís,&nbsp;Iola F. Duarte,&nbsp;Ricardo J. B. Pinto,&nbsp;Helena Oliveira,&nbsp;José M. Oliveira,&nbsp;Armando J. D. Silvestre,&nbsp;Carla Vilela and Carmen S. R. Freire*,&nbsp;","doi":"10.1021/acsbiomaterials.4c0214810.1021/acsbiomaterials.4c02148","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.4c02148https://doi.org/10.1021/acsbiomaterials.4c02148","url":null,"abstract":"<p >The successful replication of the intricate architecture of human tissues remains a major challenge in the biomedical area. Three-dimensional (3D) bioprinting has emerged as a promising approach for the biofabrication of living tissue analogues, taking advantage of the use of adequate bioinks and printing methodologies. Here, a hydrogel bioink based on gelatin (Gel) and nanofibrillated cellulose (NFC), cross-linked with genipin, was developed for the 3D extrusion-based bioprinting of hepatocarcinoma cells (HepG2). This formulation combines the biological characteristics of Gel with the exceptional mechanical and rheological attributes of NFC. Gel/NFC ink formulations with different Gel/NFC mass compositions, viz., 90:10, 80:20, 70:30, and 60:40, were prepared and characterized. The corresponding cross-linked hydrogels were obtained using 1.5% (w/w) genipin as the cross-linking agent. The rheological and mechanical performances of the inks were enhanced by the addition of NFC, as evidenced by the rise in the yield stress from 70.9 ± 28.6 to 627.9 ± 74.8 Pa, compressive stress at 80% strain from 0.5 ± 0.1 to 1.5 ± 0.2 MPa, and Young’s modulus from 4.7 ± 0.9 to 12.1 ± 1.1 MPa, for 90:10 and 60:40 inks, respectively. Moreover, higher NFC contents translated into 3D structures with better shape fidelity and the possibility of printing more intricate structures. These hydrogels were noncytotoxic toward HepG2 cells for up to 48 h, with cell viabilities consistently above 80%. The ink 70:30 was loaded with HepG2 cells (2 × 10⁶ cells mL^–1) and bioprinted. Cell viability remained elevated (90 ± 4%) until day 14 postbioprinting, with cells maintaining their metabolic activity shown by ¹H NMR metabolomics, proving the enormous potential of Gel/NFC-based bioinks for bioprinting HepG2 cells without jeopardizing their viability and metabolism.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 5","pages":"3043–3057 3043–3057"},"PeriodicalIF":5.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143934191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Innovations of Antimicrobial Polymers for Combating Antimicrobial Resistance","authors":"Zhangyong Si*,&nbsp; and ,&nbsp;Mary B. Chan-Park*,&nbsp;","doi":"10.1021/acsbiomaterials.4c0214710.1021/acsbiomaterials.4c02147","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.4c02147https://doi.org/10.1021/acsbiomaterials.4c02147","url":null,"abstract":"<p >The global rise of antimicrobial resistance (AMR) has rendered many traditional antibiotics ineffective, leading to an urgent need for alternative therapeutic strategies. Antimicrobial polymers, with their ability to rapidly kill bacteria by disrupting or crossing membranes and/or targeting multiple microbial functions without inducing resistance, offer a promising solution. This perspective explores recent innovations in the design and synthesis of antimicrobial polymers, focusing on their chemical motifs, structural derivatives, and their applications in combating systemic and topical infections. We also highlight key challenges in translating these materials from laboratory research to clinical practice, including issues related to the high dose required, bioavailability and stability in systemic infection treatment, and ability to disperse and kill biofilms in localized infection management. By addressing these challenges, antimicrobial polymers could play a crucial role in the development of next-generation therapeutics to combat multidrug-resistant pathogens. This perspective attempts to summarize significant insights for the design and development of advanced antimicrobial polymers to overcome AMR, offering potential pathways to improve clinical outcomes in treating systemic and local infections.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 5","pages":"2470–2480 2470–2480"},"PeriodicalIF":5.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143934186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}