ACS Biomaterials Science & Engineering最新文献

{"title":"","authors":"Ran Xu, Ying Lu, Luyun Cai* and Litao Zhang, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.4c02346","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144373859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Yixun Li, Xinyu Li, Zhiwei Liu, Yuehua Wang* and Tifeng Jiao*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.5c00142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144373867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Jinglin Zhang*, Shuoyan Jiang, Huidi Liu, Zengxi Wang, Xiang Cai and Shaozao Tan*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.5c00087","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144373879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Yihao Yuan, Jiapeng Li, Guotao Wei, Ziyi Shen, Bo Li*, Jiawei Wu* and Jing Liu, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.4c02029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144373880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/abv011i006_1943801","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144373891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Wenyi Zhao, Ying Chen, Lei Yang, Chunyong Liang*, Donghui Wang* and Hongshui Wang*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.5c00155","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144358020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-Printed Cell-Instructive Scaffolds Based on <i>Chondrosia reniformis</i> Collagen and Sr-Doped Calcium Phosphates for Bone Tissue Engineering.","authors":"Miguel S Rocha, Catarina F Marques, Sandra Pina, Joaquim M Oliveira, Rui L Reis, Tiago H Silva","doi":"10.1021/acsbiomaterials.4c01926","DOIUrl":"10.1021/acsbiomaterials.4c01926","url":null,"abstract":"<p><p>Bone defects pose a global concern due to their high prevalence. Despite the significant advances in the development of novel therapies and sustainable biomaterial solutions, these still do not perfectly address the clinical needs, in particular, the paradigm shift of personalized treatments. In this sense, marine-origin materials allied to three-dimensional (3D) printing are arising as a feasible alternative to develop innovative personalized approaches, namely, bone tissue engineering (TE). In this study, novel 3D-printed scaffolds composed of collagen obtained from the maricultured marine sponge <i>Chondrosia reniformis</i> and calcium phosphates extracted from codfish (<i>Gadus morhua</i>) bones doped with strontium, and combined with alginate, were developed as a promising approach for bone regeneration. The 3D-printed scaffolds demonstrated suitable pore size and porosity and high interconnectivity, with adequate mechanical properties for bone TE. The <i>in vitro</i> assays conducted with a human osteosarcoma cell line (Saos-2 cells) cultured onto the 3D-printed scaffolds demonstrated a notable improvement in both cell viability and proliferation up to 14 days of culturing. This enhancement was particularly evident in the case of 3D-printed scaffolds containing Sr-doped calcium phosphates. Aligned with the principles of the blue economy and within a sustainable development approach, an innovative 3D-printed scaffold produced from sustainable marine-derived collagen and strontium-doped calcium phosphates with adequate mechanical properties, architecture, and encouraging <i>in vitro</i> performance was developed for bone tissue engineering scaffolding applications.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"3547-3559"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineered PLGA Nanoparticles for Brain-Targeted Codelivery of Cannabidiol and pApoE2 through the Intranasal Route for the Treatment of Alzheimer's Disease.","authors":"Arun Kumar Mahanta, Bivek Chaulagain, Avinash Gothwal, Jagdish Singh","doi":"10.1021/acsbiomaterials.5c00465","DOIUrl":"10.1021/acsbiomaterials.5c00465","url":null,"abstract":"<p><p>Neuroinflammation induced by the accumulation of amyloid beta plaques expedites the progression of Alzheimer's disease (AD). Reducing Aβ plaques and associated neuroinflammation could potentially help to delay the progression of AD. Cannabidiol (CBD) is well-known for its antioxidant, anti-inflammatory, and neuroprotective nature, and the ApoE2 is effective in binding and clearing Aβ plaques in the brain. Therefore, codelivery of CBD and pApoE2 to the brain would be a promising therapeutic approach in developing effective therapeutics against AD. This research aims to design a nonviral delivery agent that delivers both drugs and genes to the brain through a noninvasive intranasal route. We have developed mPEG-PLGA nanoparticles coated with mannose, a brain-targeting ligand, to deliver CBD and pApoE2. The designed CBD-loaded coated nanoparticles showed an average diameter of 179.3 ± 4.57 nm and a zeta potential of 30.3 ± 6.45 mV. The coated nanoparticles prolonged the CBD release and showed a 93% release of its payload in 30 days. CBD-loaded nanoparticles, as compared to the free CBD, significantly reduced lipopolysaccharide and amyloid beta-induced inflammation in immortalized microglia cells. Cytotoxicity of the designed nanoparticles was assessed against brain endothelial cells (bEND.3) and found to be nontoxic in nature. The mannose-conjugated chitosan-coated nanoparticles were cationic and able to bind with the pApoE2, protecting the encapsulated pApoE2 from enzymatic degradation. Quantitative in vitro transfection efficiency study in primary astrocytes and primary neurons revealed that the ApoE2 expression level is significantly (<i>P</i> < 0.0001) higher for mPLGA-CBD-MC/pApoE2 than the control. The ApoE2 expression level in the brain of C57BL6/J mice was significantly (<i>P</i> < 0.0001) increased after intranasal administration of mPLGA-CBD-MC/pApoE2. Henceforth, the mannose-conjugated chitosan-coated mPLGA nanoparticles could serve as a nonviral delivery system to deliver both drugs and genes to the brain through the intranasal route for the management of AD.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"3533-3546"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering Mechanical Microenvironments: Integration of Substrate and Flow Mechanics Reveals the Impact on the Endothelial Glycocalyx.","authors":"Mohammad Hamrangsekachaee, Yu Chen, Emily R Tressler, Lucas McCauley, Nicholas R O'Hare, Chinedu C Okorafor, Sidi A Bencherif, Eno E Ebong","doi":"10.1021/acsbiomaterials.4c02401","DOIUrl":"10.1021/acsbiomaterials.4c02401","url":null,"abstract":"<p><p>The glycocalyx (GCX), a multicomponent coating on endothelial cells (ECs), plays a critical role in various cellular behaviors, including barrier formation, vasodilation, and mechanotransduction. Mechanical perturbations in the vascular environment, such as blood vessel stiffness, are sensed and transduced by ECs via the GCX. Hypertension-induced stiffness disrupts GCX-mediated mechanotransduction, leading to EC dysfunction and atherosclerotic cardiovascular diseases. Understanding GCX-regulated mechanotransduction necessitates an in vitro model that closely mimics in vivo conditions. Existing models are insufficient, prompting the development of the system described in this manuscript. Here, we report on a new system to model varying EC substrate stiffness under sustained physiological fluid shear stress, providing a realistic environment for comprehensive examination of EC function. Gelatin methacrylate (GelMA) substrates with stiffnesses of 5 kPa (physiological) and 10 kPa (pathological) were seeded with human umbilical vein ECs (HUVECs) and subjected to constant physiological shear stress (12 dyn/cm²) for 6 h. Analysis focused on heparan sulfate (HS), sialic acid (SA), hyaluronic acid (HA), syndecan-1 (SDC1), cluster of differentiation 44 (CD44), and Yes-associated protein (YAP). Compared to the 5 kPa conditions, HS coverage and thickness decreased at 10 kPa, indicating impaired barrier function and increased susceptibility to inflammatory agents. SA density increased despite decreased coverage, suggesting enhanced binding site availability for inflammatory recruitment. HA expression remained unchanged, but the amount of the HA core receptor, CD44, was found to be increased at 10 kPa. Consistent with previously published interactions between CD44 and YAP, we observed increased YAP activation at 10 kPa, as evidenced by increased nuclear translocation and decreased phosphorylation. These findings, bridging biomaterials and mechanobiology approaches, deepen our understanding of how mechanical stimuli influence the EC GCX function. The results underscore the potential of mechanotherapeutic strategies aimed at preserving vascular health by modulating the endothelial function.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"3416-3431"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening of Biomaterials for Stem Cell Culture Applications.","authors":"Margot J Amitrano, Mina Cho, William L Murphy","doi":"10.1021/acsbiomaterials.5c00088","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.5c00088","url":null,"abstract":"<p><p>Stem cells have a considerable role to play in future biomedical breakthroughs due to their therapeutic potential. As stem cells may be studied in a variety of different applications, a \"one size fits all\" approach to the stem cell culture substrate is not appropriate. Different biomaterial formulations may be necessary in different contexts. Screening can help identify biomaterials for specific applications to harness stem cells' full potential. In this review, we cover experimental setups appropriate for screening applications, as well as data collection tools for both material and cell characterization. Finally, we cover high throughput data processing techniques, emphasizing the potential of introducing machine learning (ML) techniques into the analytical process. With increased use of ML-based analytical techniques, biomaterial screening has the potential to contribute to the rapid development of biomaterials for targeted stem cell applications.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}