ACS Biomaterials Science & Engineering最新文献

{"title":"Electrospun Nanofiber Dressings for Diabetic Wounds: From Single-Layer to Intelligent Composite Systems","authors":"Yuqing Dong,&nbsp;Wenbo Wu,&nbsp;Xinyu Li,&nbsp;Renat Khaydarov,&nbsp;Lexin Zhang,&nbsp;Tifeng Jiao","doi":"10.1021/acsbiomaterials.6c00723","DOIUrl":"10.1021/acsbiomaterials.6c00723","url":null,"abstract":"<p>Diabetic chronic wounds have become a major challenge for clinical treatment due to their complex pathological microenvironment, including persistent inflammatory response, angiogenesis disorder, excessive oxidative stress, and susceptible infection. Traditional dressings as a passive barrier have difficulty meeting the above multiple treatment needs. Electrospinning technology, with its ability to mimic the fibrous network structure of the natural extracellular matrix (ECM), offers a high specific surface area, controllable porosity, and excellent drug-loading capacity, making it an ideal platform for developing a new generation of multifunctional wound dressings. This article provides a systematic review of the research progress on electrospun nanofiber dressings in the treatment of diabetic wounds, focusing on the design evolution from basic single-layer structures to advanced complex structures and elucidating the mechanisms of action and quantifiable effects of each structural type in addressing specific pathological challenges. We also compared the current status of clinical translation for electrospun dressings with that of other advanced wound care platforms and proposed a standardized preclinical evaluation framework. A large number of research data show that these advanced designs can effectively improve the quality of healing. Finally, this paper points out the challenges faced by this field, such as scalable fabrication, in vivo reliability of smart systems, and long-term biosafety, and provides theoretical basis and technical reference for the design of efficient and intelligent electrostatic spinning diabetic wound dressings.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"12 9","pages":"4673–4708"},"PeriodicalIF":6.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148785377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Injury-Conforming Dual-Layer Lung Sealant","authors":"Shadi Sarami,&nbsp;Mohammad Mir,&nbsp;Yuvaraj Manchukan,&nbsp;Jun Tae Huh,&nbsp;Aneri Patel,&nbsp;Gordana Vunjak-Novakovic,&nbsp;Jinho Kim","doi":"10.1021/acsbiomaterials.6c00331","DOIUrl":"10.1021/acsbiomaterials.6c00331","url":null,"abstract":"<p>Persistent pulmonary air leaks contribute to prolonged hospitalization. While existing hydrogel-based sealants can be used to stop air leaks, they may lack the high elasticity needed to accommodate lung deformation and mechanical cohesion. We developed an injury-conforming sealant with an adhesion layer underneath a customized bioprinted reinforcement layer. The leak- and rupture-pressure tests demonstrated substantial improvement in adhesive and cohesive strengths of the dual-layer sealant compared to single-layer control. We also developed a computer vision-guided tracking method to quantitatively assess sealant–tissue compliance during ventilation in ex vivo swine lungs. When used to repair air leaks on ventilated swine lungs, the sealant maintained structural integrity during cyclic ventilation, exhibiting a dynamic strain of 13.4% ± 0.8% relative to 19.7% ± 0.3% in the underlying tissue. The sealant repaired the leak and restored peak-inspiratory pressure (PIP) to baseline levels (PIP_Native: 30.0 ± 0.8 cmH₂O; PIP_Injured: 25.3 ± 0.6 cmH₂O; PIP_Sealed: 29.5 ± 1.3 cmH₂O). Collectively, our findings demonstrate that the injury-conforming dual-layer sealant effectively seals pulmonary air leak while accommodating cyclic tissue deformation during ventilation.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"12 9","pages":"4907–4920"},"PeriodicalIF":6.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148696806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Stiffness of Bone Extracellular Matrix Derived Scaffolds Regulates Macrophage Function and Osteogenesis of Mesenchymal Stromal Cells","authors":"Giovanni Gonnella,&nbsp;Sinead A. O’Rourke,&nbsp;Aisling Dunne,&nbsp;Daniel J. Kelly","doi":"10.1021/acsbiomaterials.6c00404","DOIUrl":"10.1021/acsbiomaterials.6c00404","url":null,"abstract":"<p>Bone extracellular matrix (ECM) derived biomaterials possess intrinsic osteoinductive properties, motivating their use as scaffolds for bone and osteochondral defect repair. However, their translation is limited by the need for scalable and reproducible ECM extraction protocols and by their poor mechanical properties when processed into porous scaffolds. Furthermore, it is unclear how the stiffness of ECM-derived scaffolds, a known regulator of mesenchymal stromal/stem cell (MSC) differentiation, impacts their ability to support osteogenesis. To address these challenges, this study first sought to develop a robust ECM extraction process from porcine bone, and secondly to fabricate solubilized bone ECM scaffolds with tuneable mechanical properties to assess how their stiffness influences osteogenesis of MSCs and macrophage phenotype. Using an optimised bone ECM extraction protocol, we produced scaffolds with a unidirectional pore architecture using ECM concentrations of 2%, 4%, and 6% w/v to examine the effect of matrix content on scaffold mechanical properties and osteogenic potential. Scaffold stiffness increased with bone ECM concentration, from 2 kPa for 2% ECM to 14 kPa for 6% ECM. All scaffolds displayed low levels of permanent deformation (&lt;5%) following large strains, demonstrating their highly elastic nature. Increased scaffold stiffness also influenced MSC behaviour, with DNA content almost doubling over culture, and the stiffest scaffold supporting approximately 33% more mineral deposition and almost 100% more collagen deposition compared to the softer scaffolds. Furthermore, bone ECM scaffolds modulated the function of primary human macrophages, leading to a downregulation of the proinflammatory factors and an upregulation in angiogenic growth factors supportive of bone regeneration. In conclusion, we established a reliable protocol for bone ECM extraction from porcine tissue and demonstrated that scaffold stiffness can be finely tuned to regulate both MSC fate and macrophage polarization.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"12 9","pages":"4921–4933"},"PeriodicalIF":6.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148785408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of Mechanically Adjustable Silk Fibroin-Based Hydrogels with Excellent Biocompatibility for Skin Wound Repair","authors":"Yanai Chen,&nbsp;Jiahao Zhao,&nbsp;Xinyu Wu,&nbsp;Xiaomeng Shi,&nbsp;Qi Hu,&nbsp;Shenzhou Lu","doi":"10.1021/acsbiomaterials.6c00993","DOIUrl":"10.1021/acsbiomaterials.6c00993","url":null,"abstract":"<p>Silk fibroin (SF) hydrogels have attracted widespread attention as promising wound dressings owing to their excellent biocompatibility and tunable structure. However, constructing SF hydrogels with easily adjustable mechanical properties and clarified structure–function relationships remains challenging. Herein, we fabricated a series of mechanically tunable SF hydrogels using ethylene glycol diglycidyl ether (EGDE) as a biocompatible crosslinker. The epoxy groups of EGDE readily react with the nucleophilic amino and hydroxyl groups on SF chains via ring-opening reactions, forming stable covalent crosslinks. By systematically optimizing the SF concentration, crosslinker molar ratio, and reaction temperature, hydrogels with well-defined porous architectures, stable crosslinked networks, and favorable biosafety were obtained. Among them, the 150-90-1 hydrogel exhibited optimal comprehensive performance, with a compressive strength of ∼250 kPa, a tensile strength of ∼280 kPa, and an adhesion strength of ∼4.5 kPa to porcine skin. In vitro results confirmed that the hydrogel had cell viability above 90% and supported cell survival and proliferation. In vivo experiments using a mouse full-thickness skin wound model demonstrated that the hydrogel significantly accelerated wound closure, attenuated inflammatory infiltration, promoted re-epithelialization and collagen deposition, and enhanced angiogenesis by upregulating VEGF (28% at day 3; 47.8% at day 12) and CD31 (14.5% at day 3; 24.5% at day 12) while downregulating IL-6. Mechanistically, the negatively charged SF backbone enriched the positively charged endogenous VEGF through electrostatic interactions, and the hydrogel acted as a protective physical barrier to maintain a stable wound microenvironment. This work provides a facile strategy for developing mechanically adjustable SF hydrogels and elucidates their regulatory mechanism in wound repair, highlighting their great potential as safe and effective wound dressings.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"12 9","pages":"5075–5086"},"PeriodicalIF":6.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148862574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Nanoarmored Lactobacillus rhamnosus with Inflammation Targeting and Scavenging Activities for Colitis Lesion-Specific Therapy","authors":"Wen Li,&nbsp;Siyuan Yuan,&nbsp;Hongjing Wu,&nbsp;Menglin Huang,&nbsp;Xue Yang,&nbsp;Yuqin Zou,&nbsp;Xiaomei Dai,&nbsp;Feng Gao","doi":"10.1021/acsbiomaterials.6c00800","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.6c00800","url":null,"abstract":"<p>Nanoarmored probiotics with inflammation targeting and scavenging activities without complex synthetic procedure is important for maintaining their native bioactivity, yet it remains a challenge. In this work, we demonstrated the multifunctional nanoparticle (QL@PS NP)-armored <em>Lactobacillus rhamnosus</em> (LAB) with inflammation targeting and regulation activity for inflammatory bowel disease (IBD) treatment. QL@PS NPs were assembled by quercetin (Que), lipoic acid (LA), and phosphatidylserine (PS), which could target macrophages and degrade in reactive oxygen species (ROS)-rich lesion sites, exhibiting excellent antioxidant and anti-inflammatory capability <em>in vitro</em>. QL@PS NPs were coated on the surface of thiolated LAB under a cell-friendly condition, and the resulting nanoarmored probiotic (LAB@NPs) could protect LAB from the gastrointestinal assaults and ROS damage. LAB@NPs are more likely to be up-taken by macrophages, scavenging oxidative stress and regulating the inflammatory microenvironment of colitis lesions through the synergistic effect of probiotics and QL@PS NPs. <em>In vivo</em> experimental results certified that LAB@NPs achieved notable lesion-specific therapeutic efficacy in mouse colitis models, significantly ameliorating colon shortening, reducing inflammatory reactions and pathological tissue damage. This work provides a facile and effective strategy to construct nanoarmored probiotics for therapy of IBD.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"12 9","pages":"5051–5062"},"PeriodicalIF":6.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148950689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic In Situ Bioprinting in Tissue Engineering: Technologies, Challenges, and Clinical Perspectives","authors":"Zitong Wang,&nbsp;Shuoyu Ji,&nbsp;Kang Li,&nbsp;Yongheng Li,&nbsp;Yihao Ye,&nbsp;Zhihong Cao,&nbsp;Changru Zhang,&nbsp;Jinwu Wang","doi":"10.1021/acsbiomaterials.6c00639","DOIUrl":"10.1021/acsbiomaterials.6c00639","url":null,"abstract":"<p>In situ bioprinting offers a compelling alternative to conventional tissue engineering by directly depositing biomaterials, cells, and bioactive factors at defect sites for localized tissue fabrication. Robotic in situ bioprinters, integrating additive manufacturing with surgical robotics, have emerged as a promising substitute for handheld systems. However, this field remains at an early stage, with existing studies largely limited to specific devices or isolated applications and lacking systematic reviews that compare diverse technological approaches. Key issues such as the compatibility between bioprinting modalities and robotic platforms, the design considerations of end-effectors, strategies for path planning and control, and applications across different organs have yet to be comprehensively synthesized. This review addresses these gaps by providing a structured overview of current progress, highlighting common challenges, and outlining future directions toward clinical translation.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"12 9","pages":"4646–4672"},"PeriodicalIF":6.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148696827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Dimensional Printing of Polycaprolactone Scaffolds with Multiscale Porosity for Bone Tissue Engineering","authors":"Mikaela Kutrolli,&nbsp;Noah S. Pereira,&nbsp;Delaram Ghanbariamin,&nbsp;Katherine M Arnold,&nbsp;Alix Deymier,&nbsp;Mohamadmahdi Samandari,&nbsp;Ali Tamayol","doi":"10.1021/acsbiomaterials.6c00276","DOIUrl":"10.1021/acsbiomaterials.6c00276","url":null,"abstract":"<p>Extrusion-based three-dimensional printing enables the fabrication of patient-specific scaffolds. Polycaprolactone (PCL)-based scaffolds have been widely used for the treatment of bone defects. However, extruded filaments are typically nonporous, which can prolong their degradation, limit cell adhesion and infiltration, and therefore interrupt normal tissue regeneration. Here, we present a simple and scalable method to generate polymeric scaffolds with hierarchical porosity by incorporating sacrificial sugar particles in a printable PCL ink. Microstructural analysis by SEM demonstrates an average pore size of around 10 μm with increased pore density at higher porogen fractions. Porous PCL improved apparent wettability and protein adsorption, accelerated hydrolytic degradation by more than five-fold, and enabled tunable mechanical properties. Printability testing shows improved filament stability and reduced fusion at higher porogen loading, enabling significantly higher printing resolution. In vitro evaluation demonstrates enhanced early preosteoblast attachment on porous scaffolds (&gt;three-fold), without loss of cytocompatibility. Importantly, porous scaffolds support osteogenic differentiation of the cells and mineralization. This study provides a practical framework for creating intrafilamentary porosity into 3D-printed PCL scaffolds with improved surface-mediated biological performance.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"12 9","pages":"4894–4906"},"PeriodicalIF":6.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148785365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mannosylated Spleen-Targeted Lipid Nanoparticles Enable Enhanced mRNA Delivery to Antigen-Presenting Cells","authors":"Shu Zhang,&nbsp;Yaxi Li,&nbsp;Aygun Teymur,&nbsp;Bowen Yang,&nbsp;Sheereen Majd,&nbsp;Chandra Mohan,&nbsp;Tianfu Wu","doi":"10.1021/acsbiomaterials.6c00494","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.6c00494","url":null,"abstract":"<p>Targeted delivery of lipid nanoparticles (LNP) to immune organs remains challenging, and here we introduce a mannosylated spleen-targeted LNP (LNP-PAM) that integrates active and endogenous targeting to enhance mRNA delivery to antigen-presenting cells. A mannose-conjugated fifth lipid (PA-Mannose, PAM) was incorporated into spleen-targeted LNPs at varying molar ratios, followed by a systematic evaluation of physicochemical properties, in vitro transfection, in vivo biodistribution, cellular uptake, and mRNA expression. All formulations exhibited uniform particle size and low polydispersity, and increasing PAM content from 5% to 10% shifted LNP accumulation from the liver to the spleen, ultimately achieving exclusive spleen localization. LNP-PAM showed superior in vitro transfection in macrophages relative to conventional LNPs and higher in vivo mRNA expression in the spleen, with flow cytometry confirming preferential uptake by macrophages and type-2 conventional dendritic cells (cDC2) populations consistent with CD206-mediated endocytosis. The system maintained physicochemical stability after freeze−thaw and demonstrated minimal cytotoxicity. Together, these findings indicate that mannosylation enhances spleen-targeted mRNA delivery through receptor-mediated uptake by macrophages and dendritic cells without compromising formulation robustness, positioning LNP-PAM as a practical platform for selective immune organ delivery and RNA-based immunomodulation.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"12 9","pages":"4793–4802"},"PeriodicalIF":6.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148950616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient Antimicrobial Nanoenzymatic Functionalized Hydrogels for Diabetic Infected Wound Treatment","authors":"Changyu Yao,&nbsp;Dongqin Zhang,&nbsp;Jiaqi Kan,&nbsp;Weibin Shao,&nbsp;Chi Zhang,&nbsp;Rupei Tang","doi":"10.1021/acsbiomaterials.6c00881","DOIUrl":"10.1021/acsbiomaterials.6c00881","url":null,"abstract":"<p>The high glycemic environment of diabetic wounds predisposes to bacterial infections that seriously threaten the wound healing process. Therefore, inhibition of bacterial infection and remodeling of the wound microenvironment are crucial for the healing of diabetic infected wounds. In this study, gold nanoparticles (Au NPs) and glucose oxidase (GOx) were loaded in situ onto the surface of zeolitic imidazolate framework-8 nanoparticles (ZIF-8 NPs) to prepare ZIF-8@Au@GOx (ZAG) nanoenzymes. It catalyzed the production of glucuronic acid and H₂O₂ from glucose, lowered the wound pH, promoted the release of Zn²⁺, and catalyzed the production of hydroxyl radicals (^·OH) from H₂O₂, thus serving to regulate the wound microenvironment, reducing glucose levels, and providing efficient antimicrobial activity. Subsequently, the nanoenzymes were loaded into β-cyclodextrin-based host–guest interaction and perylene-bonded tandem highly dynamic adaptive (DSA) hydrogels to obtain nanoenzyme-functionalized hydrogels (ZAG@Gel). The hydrogel could adapt to the shape of the wound, effectively fit the damaged skin, and play a role in reducing the toxicity and slowing down the release. In vitro studies showed that ZAG@Gel could release ZAG nanoenzymes in situ, causing the bacterial surface to crumple, the cell membrane structure to be disrupted, and the internal substances to be leaked. In vivo animal experiments showed that the wound healing rate after ZAG@Gel treatment reached nearly 98.06%. Thus, this highly effective antibacterial nanoenzyme-functionalized hydrogel has a strong bactericidal ability and shows good pro-diabetic infected wound healing properties.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"12 9","pages":"4819–4832"},"PeriodicalIF":6.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148682679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Dual-Crosslinked Collagen/Hyaluronic Acid/Chitosan Hydrogel for Integrated Hemostasis and Infected Wound Healing","authors":"Sheji Weng,&nbsp;Zhongqin Lin,&nbsp;Kai Tan,&nbsp;Zhengyang Long,&nbsp;Lei Yang,&nbsp;Bin Chen,&nbsp;Qin Zhang,&nbsp;Weikai Chen","doi":"10.1021/acsbiomaterials.6c00891","DOIUrl":"10.1021/acsbiomaterials.6c00891","url":null,"abstract":"<p>Conventional wound dressings often fail to integrate rapid hemostasis, antibacterial protection, and a pro-regenerative microenvironment, leading to persistent infection and delayed healing in complex wounds. Herein, we report a multifunctional self-adhesive hydrogel for integrated hemostatic, antibacterial, and regenerative wound management with a synergistic dual-crosslinked network. The hydrogel is composed of methylacrylamide-modified type I collagen (ColMA), <em>o</em>-nitrobenzene-modified hyaluronic acid (HANB), and methylacrylamide-modified chitosan (CSMA), and can rapidly form in situ under UV irradiation through free-radical polymerization of methacrylamide groups and Schiff base reactions between HANB and amino groups on ColMA/CSMA. Once applied to infected wounds, the hydrogel rapidly seals the wound bed and adheres tightly to the tissue, where HANB contributes hemostatic and adhesive properties, CSMA provides intrinsic antibacterial activity to inhibit bacterial colonization, and ColMA offers extracellular matrix-mimicking cues to support cell adhesion and tissue regeneration. Through this coordinated mechanism, the hydrogel not only controls bleeding and reduces infection risk at the early stage but also promotes the growth of granulation tissue, re-epithelialization, and matrix reconstruction during the subsequent repair phase. This platform integrates wound closure, antibacterial defense, and tissue regeneration into a single dressing system, acting as a promising strategy for the treatment of infected wounds.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"12 9","pages":"4993–5004"},"PeriodicalIF":6.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148785423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}