ACS Biomaterials Science & Engineering最新文献_第8页

One-Step Synthesis for Orn-Val with High Molecular Weight and Low Polydispersity by Ugi Four-Component Condensation. 通过 Ugi 四组份缩合一步合成高分子量、低多分散性的 Orn-Val。

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2024-11-27 DOI: 10.1021/acsbiomaterials.4c01379

Junhui Ma, Nan Ma, Jun Liu, Qiongqiong Zhu, Yan Tang, Lei Wang, Yan Yan, Ting Yue, Meiyu Shao, Wei Zhang

{"title":"One-Step Synthesis for Orn-Val with High Molecular Weight and Low Polydispersity by Ugi Four-Component Condensation.","authors":"Junhui Ma, Nan Ma, Jun Liu, Qiongqiong Zhu, Yan Tang, Lei Wang, Yan Yan, Ting Yue, Meiyu Shao, Wei Zhang","doi":"10.1021/acsbiomaterials.4c01379","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.4c01379","url":null,"abstract":"Basic amino acid alternating copolymers exhibit exceptional antimicrobial properties and biosafety, yet their application is restricted by the complexity of the synthesis process and low molecular weight (Mn = 1000). In this study, we synthesized a basic amino acid alternating copolymer (Orn-Val) in only one step by the Ugi four-component condensation (Ugi'4CC), achieving high molecular weight (Mn = 20,000) and narrow polydispersity (PDI ≤ 1.10). Furthermore, we observed that factors such as the feed ratio, reaction solvent, and pH significantly influenced the molecular weight and polydispersity of MPE-Orn-Val-Cbz. Moreover, the structure of potassium isocyanate also significantly affected the molecular weight and polydispersity of the products. And it was also demonstrated that the obtained Orn-Val demonstrated excellent antimicrobial properties and biocompatibility. Therefore, this method effectively addresses the limitations associated with the complex synthesis process and low molecular weight of amino acid alternating copolymers.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142737719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Biocompatible Ti-MOF@hydroxyapatite Composite Boosted with Gentamicin for Postoperative Infection Control 新型生物相容性 Ti-MOF@hydroxyapatite 复合材料添加庆大霉素用于术后感染控制

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2024-11-26 DOI: 10.1021/acsbiomaterials.4c0123010.1021/acsbiomaterials.4c01230

Weronika Bodylska*, Adam Junka, Malwina Brożyna, Michał Bartmański, Renata Gadzała-Kopciuch, Anna Jaromin, Jorge A. R. Navarro, Anna Lukowiak and Marzena Fandzloch*,

{"title":"New Biocompatible Ti-MOF@hydroxyapatite Composite Boosted with Gentamicin for Postoperative Infection Control","authors":"Weronika Bodylska*, Adam Junka, Malwina Brożyna, Michał Bartmański, Renata Gadzała-Kopciuch, Anna Jaromin, Jorge A. R. Navarro, Anna Lukowiak and Marzena Fandzloch*, ","doi":"10.1021/acsbiomaterials.4c0123010.1021/acsbiomaterials.4c01230","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.4c01230https://doi.org/10.1021/acsbiomaterials.4c01230","url":null,"abstract":"The standard clinical management of osteomyelitis involves prolonged antibiotic therapy, which frequently necessitates the excision of infected tissues. However, the efficacy of such treatments is increasingly compromised by the rise of antibiotic-resistant pathogens, underscoring an urgent need for innovative approaches. This study introduces a novel composite material designed to offer dual functionality: robust antimicrobial activity and promotion of bone regeneration. The composite integrates biocompatible hydroxyapatite nanoparticles (HA) with a titanium(IV)–metal–organic framework, MIL-125(Ti)-NH2, impregnated with gentamicin (GM). The solvothermally synthesized MIL-125-NH2@HA composite demonstrates high cytocompatibility, as evidenced by assays using osteoblasts (U2-OS) and fibroblasts (L929), alongside an absence of hemolytic activity at concentrations of up to 1000 μg/mL. Importantly, the introduction of GM into the composite significantly amplifies its antibacterial efficacy against Staphylococcus aureus and Pseudomonas aeruginosa. Additionally, nanoindentation assessments reveal enhanced mechanical properties of the MIL-125-NH2@HA composite, indicating the superior elastic performance relative to unmodified HA. The findings of this research are poised to generate significant interest in the development of metal–organic framework (MOF)-based composites for antimicrobial implant applications, presenting a promising avenue for addressing the challenges posed by antibiotic resistance in bone infections.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"10 12","pages":"7555–7565 7555–7565"},"PeriodicalIF":5.4,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142843440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical and Physical Characterization of a Biphasic 3D Printed Silk-Infilled Scaffold for Osteochondral Tissue Engineering

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2024-11-26 DOI: 10.1021/acsbiomaterials.4c0186510.1021/acsbiomaterials.4c01865

T. Braxton*, K. Lim, C. Alcala-Orozco, H. Joukhdar, J. Rnjak-Kovacina, N. Iqbal, T. Woodfield, D. Wood, C. Brockett and X.B. Yang*,

{"title":"Mechanical and Physical Characterization of a Biphasic 3D Printed Silk-Infilled Scaffold for Osteochondral Tissue Engineering","authors":"T. Braxton*, K. Lim, C. Alcala-Orozco, H. Joukhdar, J. Rnjak-Kovacina, N. Iqbal, T. Woodfield, D. Wood, C. Brockett and X.B. Yang*, ","doi":"10.1021/acsbiomaterials.4c0186510.1021/acsbiomaterials.4c01865","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.4c01865https://doi.org/10.1021/acsbiomaterials.4c01865","url":null,"abstract":"Osteochondral tissue damage is a serious concern, with even minor cartilage damage dramatically increasing an individual’s risk of osteoarthritis. Therefore, there is a need for an early intervention for osteochondral tissue regeneration. 3D printing is an exciting method for developing novel scaffolds, especially for creating biological scaffolds for osteochondral tissue engineering. However, many 3D printing techniques rely on creating a lattice structure, which often demonstrates poor cell bridging between filaments due to its large pore size, reducing regenerative speed and capacity. To tackle this issue, a novel biphasic scaffold was developed by a combination of 3D printed poly(ethylene glycol)-terephthalate-poly(butylene-terephthalate) (PEGT/PBT) lattice infilled with a porous silk scaffold (derived from Bombyx mori silk fibroin) to make up a bone phase, which continued to a seamless silk top layer, representing a cartilage phase. Compression testing showed scaffolds had Young’s modulus, ultimate compressive strength, and fatigue resistance that would allow for their theoretical survival during implantation and joint articulation without stress-shielding mechanosensitive cells. Fluorescent microscopy showed biphasic scaffolds could support the attachment and spreading of human mesenchymal stem cells from bone marrow (hMSC-BM). These promising results highlight the potential utilization of this novel scaffold for osteochondral tissue regeneration as well as highlighting the potential of infilling silk materials within 3D printed scaffolds to further increase their versatility.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"10 12","pages":"7606–7618 7606–7618"},"PeriodicalIF":5.4,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsbiomaterials.4c01865","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrogels Treat Atopic Dermatitis by Transporting Marine-Derived miR-100-5p-Abundant Extracellular Vesicles

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2024-11-25 DOI: 10.1021/acsbiomaterials.4c0164910.1021/acsbiomaterials.4c01649

Zijie Wu, Lei He, Linhong Yan, Baoyi Tan, Lihua Ma, Guoli He, Zhenqing Dai, Ruikun Sun and Chengyong Li*,

{"title":"Hydrogels Treat Atopic Dermatitis by Transporting Marine-Derived miR-100-5p-Abundant Extracellular Vesicles","authors":"Zijie Wu, Lei He, Linhong Yan, Baoyi Tan, Lihua Ma, Guoli He, Zhenqing Dai, Ruikun Sun and Chengyong Li*, ","doi":"10.1021/acsbiomaterials.4c0164910.1021/acsbiomaterials.4c01649","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.4c01649https://doi.org/10.1021/acsbiomaterials.4c01649","url":null,"abstract":"Atopic dermatitis (AD) is a prevalent skin disorder worldwide. However, many AD medications are unsuitable for long-term use due to low therapeutic efficacy and side effects. Extracellular vesicles (EVs) extracted from Pinctada martensii mucus have demonstrated therapeutic efficacy in AD. It is hypothesized that EVs may exert their activity on mammalian cells through their specific contents. In this study, we analyzed the results of miRNA sequencing of the EVs and investigated the potency of highly expressed miR-100-5p in treating AD. To enhance the therapeutic efficiency of the EVs in AD, we developed oxidized sodium alginate (OSA)-carboxymethyl chitosan (CMCS) self-cross-linked hydrogels as a vehicle to deliver the EVs to BALB/c mice with dermatitis. The miR-100-5p in EVs exhibited a favorable anti-inflammatory function, while the hydrogels provided enhanced skin residency. Additionally, its efficacy in inflammation inhibition and collagen synthesis was demonstrated in in vivo experiments. Mechanistically, miR-100-5p in EVs exerted anti-inflammatory effects by inhibiting the expression of FOXO3, consequently suppressing the activation of the downstream NLRP3 signaling pathway. This study underscores the significance of utilizing OSA-CMCS hydrogels as a vehicle for delivering miR-100-5p in P. martensii mucus-derived EVs for the treatment of AD.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"10 12","pages":"7667–7682 7667–7682"},"PeriodicalIF":5.4,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142850642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering Granular Hydrogels without Interparticle Cross-Linking to Support Multicellular Organization

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2024-11-25 DOI: 10.1021/acsbiomaterials.4c0156310.1021/acsbiomaterials.4c01563

Natasha L. Claxton, Melissa A. Luse, Brant E. Isakson and Christopher B. Highley*,

{"title":"Engineering Granular Hydrogels without Interparticle Cross-Linking to Support Multicellular Organization","authors":"Natasha L. Claxton, Melissa A. Luse, Brant E. Isakson and Christopher B. Highley*, ","doi":"10.1021/acsbiomaterials.4c0156310.1021/acsbiomaterials.4c01563","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.4c01563https://doi.org/10.1021/acsbiomaterials.4c01563","url":null,"abstract":"Advancing three-dimensional (3D) tissue constructs is central to creating in vitro models and engineered tissues that recapitulate biology. Materials that are permissive to cellular behaviors, including proliferation, morphogenesis of multicellular structures, and motility, will support the emergence of tissue structures. Granular hydrogels in which there is no interparticle cross-linking exhibit dynamic properties that may be permissive to such cellular behaviors. However, designing granular hydrogels that lack interparticle cross-linking but support cellular self-organization remains underexplored relative to granular systems stabilized by interparticle cross-linking. In this study, we developed a polyethylene glycol-based granular hydrogel system, with average particle diameters under 40 μm. This granular hydrogel exhibited bulk stress-relaxing behaviors and compatibility with custom microdevices to sustain cell cultures without degradation. The system was studied in conjunction with cocultures of endothelial cells and fibroblasts, known for their spontaneous network formation. Cross-linking, porosity, and cell-adhesive ligands (such as RGD) were manipulated to control system properties. Toward supporting cellular activity, increased porosity was found to enhance the formation of cellular networks, whereas RGD reduced network formation in the system studied. This research highlights the potential of un-cross-linked granular systems to support morphogenetic processes, like vasculogenesis and tissue maturation, offering insights into material design for 3D cell culture systems.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"10 12","pages":"7594–7605 7594–7605"},"PeriodicalIF":5.4,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsbiomaterials.4c01563","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142850641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outer Membrane Vesicle–Cancer Hybrid Membrane Coating Indocyanine Green Nanoparticles for Enhancing Photothermal Therapy Efficacy in Tumors

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2024-11-25 DOI: 10.1021/acsbiomaterials.4c0125110.1021/acsbiomaterials.4c01251

Jing Zhao, Bo Yu, Lujing Li, Sihua Guo, Xuan Sha, Waner Ru, Guo-Qing Du* and Jing-Yi Xue*,

引用次数: 0

Micelle-like Nanoparticles for Drug Delivery and Magnetically Enhanced Tumor Chemotherapy 用于药物输送和磁增强肿瘤化疗的胶束状纳米粒子

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2024-11-22 DOI: 10.1021/acsbiomaterials.4c0189710.1021/acsbiomaterials.4c01897

Liqin Xie*, Xirui Zuo, Beilei Wang, Dan Li, Wenke Chang, Shenglu Ji and Dan Ding,

{"title":"Micelle-like Nanoparticles for Drug Delivery and Magnetically Enhanced Tumor Chemotherapy","authors":"Liqin Xie*, Xirui Zuo, Beilei Wang, Dan Li, Wenke Chang, Shenglu Ji and Dan Ding, ","doi":"10.1021/acsbiomaterials.4c0189710.1021/acsbiomaterials.4c01897","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.4c01897https://doi.org/10.1021/acsbiomaterials.4c01897","url":null,"abstract":"Using the coordination bonds between transition metal atoms and electron-rich functional groups, we synthesized two kinds of micelle-like nanoparticles. Using magnetic Fe3O4 as the core, poly(methyl methacrylate) (PMMA) and poly(acrylic acid) (PAA) brushes were grafted via activators regenerated by electron transfer for atom transfer radical polymerization (ARGET-ATRP), which formed micelle-like magnetic nanoparticles Fe3O4/PAA–PMMA with a hydrophobic outer layer and Fe3O4/PMMA–PAA with a hydrophilic outer layer. Both the micelle-like nanoparticles had amphiphilic properties and can be used to load hydrophilic or hydrophobic drugs. Even loaded with hydrophobic drugs, the micelle-like nanoparticles can still be dispersed in aqueous solution, and Fe3O4/PAA–PMMA had a higher loading content. As the drug carrier, these two micelle-like nanoparticles can be used for magnetically targeted drug delivery and magnetic resonance imaging due to superparamagnetic Fe3O4. In addition, due to the magnetic retention effect, the drug-loaded micelle-like nanoparticles remained at the tumor site, increasing the local drug concentration. At the same time, the drug-loaded micelle-like nanoparticles generated a magnetocaloric effect under the alternating magnetic field, which not only killed tumor cells by magnetic hyperthermia but also promoted the rapid release of drugs at the tumor site. In general, magnetically enhanced chemotherapy showed the best therapeutic effect on tumors.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"10 12","pages":"7527–7538 7527–7538"},"PeriodicalIF":5.4,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142843258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnesium-Based Composite Calcium Phosphate Cement Promotes Osteogenesis and Angiogenesis for Minipig Vertebral Defect Regeneration 镁基复合磷酸钙水泥促进迷你猪椎体缺损再生中的骨生成和血管生成

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2024-11-22 DOI: 10.1021/acsbiomaterials.4c0152110.1021/acsbiomaterials.4c01521

Fang Tian, Yuqi Zhao, Yuhao Wang, Hailiang Xu, Youjun Liu, Renfeng Liu, Hui Li, Ruojie Ning, Chengwen Wang, Xinlin Gao, Rongjin Luo, Shuaijun Jia*, Lei Zhu* and Dingjun Hao*,

{"title":"Magnesium-Based Composite Calcium Phosphate Cement Promotes Osteogenesis and Angiogenesis for Minipig Vertebral Defect Regeneration","authors":"Fang Tian, Yuqi Zhao, Yuhao Wang, Hailiang Xu, Youjun Liu, Renfeng Liu, Hui Li, Ruojie Ning, Chengwen Wang, Xinlin Gao, Rongjin Luo, Shuaijun Jia*, Lei Zhu* and Dingjun Hao*, ","doi":"10.1021/acsbiomaterials.4c0152110.1021/acsbiomaterials.4c01521","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.4c01521https://doi.org/10.1021/acsbiomaterials.4c01521","url":null,"abstract":"Calcium phosphate cement (CPC) is an injectable bone cement with excellent biocompatibility, widely used for filling bone defects of various shapes. However, its slow degradation, insufficient mechanical strength, and poor osteoinductivity limit its further clinical applications. In this study, we developed a novel composite magnesium-based calcium phosphate cement by integrating magnesium microspheres into PLGA fibers obtained through wet spinning and incorporating these fibers into CPC. The inclusion of magnesium-based PLGA fibers enhanced the compressive strength and degradation rate of CPC, with the degradation rate of the magnesium microspheres being controllable to allow for the sustained release of magnesium ions. In vitro experiments showed that magnesium-based CPC enhanced the proliferation and migration of MC3T3-E1 and HUVECs. Additionally, the magnesium-based composite CPC not only enhanced osteogenic differentiation of MC3T3-E1 cells but also promoted angiogenesis in HUVECs. In vivo experiments using a vertebral bone defect model in Bama miniature pigs showed that the magnesium-based composite CPC significantly increased new bone formation. Additionally, compared to the CPC group, this composite exhibited significantly higher levels of osteogenic and angiogenic markers, with no inflammation or necrosis observed in the heart, liver, or kidneys, indicating good biocompatibility. These results suggest that magnesium-based composite CPC, with its superior compressive strength, biodegradability, and ability to promote vascularized bone regeneration, holds promise as a minimally invasive injectable material for bone regeneration.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"10 12","pages":"7577–7593 7577–7593"},"PeriodicalIF":5.4,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142843259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA Aptamers That Bind to Alginate Hydrogels

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2024-11-21 DOI: 10.1021/acsbiomaterials.4c0143610.1021/acsbiomaterials.4c01436

Ali Parvez, and , Dana A. Baum*,

{"title":"DNA Aptamers That Bind to Alginate Hydrogels","authors":"Ali Parvez,  and , Dana A. Baum*, ","doi":"10.1021/acsbiomaterials.4c0143610.1021/acsbiomaterials.4c01436","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.4c01436https://doi.org/10.1021/acsbiomaterials.4c01436","url":null,"abstract":"Hydrogels have become common in wound treatment because they form very stable and biocompatible environments that promote healing. However, due to the highly porous hydrogel structure, any therapeutic added to these gels tends to diffuse quickly and impact delivery to the target site. Aptamers are short, single-stranded DNA or RNA sequences that bind specifically to a target, so aptamers that bind to hydrogels could serve as tags for therapeutics to prevent rapid diffusion and allow for extended delivery. An in vitro selection approach was developed to identify DNA aptamers for alginate hydrogels. Two DNA aptamers were shown to bind hydrogels ranging from 0.5 to 2% alginate and could be either encapsulated during gelation or introduced to preformed gels. Both aptamers also showed specificity for binding to alginate compared to agarose. To demonstrate the functional aspect of the aptamers as tethers for other biomolecules, both aptamers were conjugated to BSA. Aptamer-conjugated BSA was retained longer in the hydrogel during week-long diffusion studies both when encapsulated or introduced to preformed gels, which adds flexibility to how these aptamers can be deployed in a clinical setting.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"10 12","pages":"7507–7515 7507–7515"},"PeriodicalIF":5.4,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142842895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrogels in Alveolar Bone Regeneration

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2024-11-21 DOI: 10.1021/acsbiomaterials.4c0135910.1021/acsbiomaterials.4c01359

Zhuoran Xu, Junyi Wang, Liheng Gao* and Wenjie Zhang*,

{"title":"Hydrogels in Alveolar Bone Regeneration","authors":"Zhuoran Xu, Junyi Wang, Liheng Gao* and Wenjie Zhang*, ","doi":"10.1021/acsbiomaterials.4c0135910.1021/acsbiomaterials.4c01359","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.4c01359https://doi.org/10.1021/acsbiomaterials.4c01359","url":null,"abstract":"Alveolar bone defects caused by oral trauma, alveolar fenestration, periodontal disease, and congenital malformations can severely affect oral function and facial aesthetics. Despite the successful clinical applications of bone grafts or bone substitutes, optimal alveolar bone regeneration continues to be challenging due to the complex oral environment and its unique physiological functions. Hydrogels that serve as promising candidates for tissue regeneration are under development to meet the specific needs for increased bone regeneration capacity and improved operational efficiency in alveolar bone repair. In this review, we emphasize the considerations in hydrogel design for alveolar bone regeneration and summarize the latest applications of hydrogels in prevalent clinical diseases related to alveolar bone defects. The future perspectives and challenges for the application of hydrogels in the field of alveolar bone regeneration are also discussed. Deepening our understanding of these biomaterials will facilitate the advent of novel inventions to improve the outcome of alveolar bone tissue regeneration.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"10 12","pages":"7337–7351 7337–7351"},"PeriodicalIF":5.4,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142842897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0