ACS Biomaterials Science & Engineering最新文献

{"title":"α-Ketoglutaric Acid Reprograms Macrophages by Altering Energy Metabolism to Promote the Regeneration of Small-Diameter Vascular Grafts.","authors":"Mengyu Li, Qi Chen, Mengxue Zhou, Xiaomeng Li, Zihao Wang, Jianglin Wang","doi":"10.1021/acsbiomaterials.4c01702","DOIUrl":"10.1021/acsbiomaterials.4c01702","url":null,"abstract":"<p><p>Small-diameter vascular grafts still cannot clinically replace autologous blood vessels due to high restenosis rates caused by long-term inflammatory infiltration. Foreign body reactions to vascular grafts induce macrophages to adopt the pro-inflammatory M1 phenotype, releasing inflammatory factors such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α). This induces a phenotypic switch in smooth muscle cells, eventually leading to intimal hyperplasia. Herein, we constructed small-diameter artificial vascular grafts capable of modulating immune responses through the controlled release of α-ketoglutaric acid (α-KG). Our findings verify that the delivery of α-KG reprograms the macrophage phenotype from a pro-inflammatory M1 to an anti-inflammatory and pro-repair M2 phenotype by regulating the energy metabolism of the tricarboxylic acid cycle (TAC). More interestingly, the delivery of α-KG positively influences the behavior of vascular cells by enhancing the proliferation of human umbilical vein endothelial cells (HUVECs) and inhibiting the expansion of mouse aortic vascular smooth muscle cells (MOVAS), thereby reducing vascular restenosis. In vivo evaluation in rabbit carotid artery replacement confirms the optimal performance of α-KG-doped vascular grafts in terms of endothelial coverage and long-term patency. Collectively, our work presents a promising approach for creating artificial vascular grafts with inflammatory regulation to ensure rapid endothelialization and sustained patency.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"518-530"},"PeriodicalIF":5.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142737726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sacrificial Templating for Accelerating Clinical Translation of Engineered Organs.","authors":"Sherina Malkani, Olivia Prado, Kelly R Stevens","doi":"10.1021/acsbiomaterials.4c01824","DOIUrl":"10.1021/acsbiomaterials.4c01824","url":null,"abstract":"<p><p>Transplantable engineered organs could one day be used to treat patients suffering from end-stage organ failure. Yet, producing hierarchical vascular networks that sustain the viability and function of cells within human-scale organs remains a major challenge. Sacrificial templating has emerged as a promising biofabrication method that could overcome this challenge. Here, we explore and evaluate various strategies and materials that have been used for sacrificial templating. First, we emphasize fabrication approaches that use highly biocompatible sacrificial reagents and minimize the duration that cells spend in fabrication conditions without oxygen and nutrients. We then discuss strategies to create continuous, hierarchical vascular networks, both using biofabrication alone and using hybrid methods that integrate biologically driven vascular self-assembly into sacrificial templating workflows. Finally, we address the importance of structurally reinforcing engineered vessel walls to achieve stable blood flow <i>in vivo</i>, so that engineered organs remain perfused and functional long after implantation. Together, these sacrificial templating strategies have the potential to overcome many current limitations in biofabrication and accelerate clinical translation of transplantable, fully functional engineered organs to rescue patients from organ failure.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"1-12"},"PeriodicalIF":5.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinspired Design of an Underwater Adhesive Based on Tea Polyphenol-Modified Silk Fibroin.","authors":"Jialuo Chen, Zhipeng Li, Xinpeng Chen, Yurong Sun, Jin Cheng, Aijing Li, Shenzhou Lu, Tieling Xing","doi":"10.1021/acsbiomaterials.4c01659","DOIUrl":"10.1021/acsbiomaterials.4c01659","url":null,"abstract":"<p><p>Adhesives have garnered significant interest recently due to their application in the field of biomedical applications. Nonetheless, developing adhesives that exhibit robust underwater adhesion and possess antimicrobial properties continues to pose a significant challenge. In this study, motivated by the adhesive mechanism observed in mussels in aquatic environments, dopamine (DA) was added to modify the silk fibroin (SF) solution. Subsequently, tea polyphenol (TP) was incorporated to form a sticky mixture, resulting in a biomimetic adhesive (TP-DA/SF). TP-DA/SF demonstrated rapid, robust, and indiscriminate adhesion to a wide array of substrates and even biological tissues (39 kPa). TP-DA/SF exhibits the ability to replicate the mussel adhesion mechanism of mussels underwater thanks to its biomimetic design. This characteristic provides the material with robust adhesion (40 kPa), notable reusability (at least 10 times), and long-lasting stability, especially in aquatic settings. It is worth noting that TP-DA/SF also demonstrated high adhesion in various water environments, even in solutions with a pH of 7.4 and buffered saline (PBS), which is one of the most widely used buffers in biochemistry research, offering salt-balancing and adjustable pH buffering capabilities. Meanwhile, TP-DA/SF exhibits excellent antibacterial and antioxidant properties due to its tea polyphenol content. After 15 days of wound closure in SD rats, the healing rate in the experimental group reached 93.4%, compared to 83.9% in the control group. Thus, the TP-DA/SF adhesive holds promising potential for biomedical applications, including sutureless wound closure and tissue adhesion.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"343-353"},"PeriodicalIF":5.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural Evolution of an Optimized Highly Interconnected Hierarchical Porous Mg Scaffold under Dynamic Flow Challenges.","authors":"Gaozhi Jia, Yicong Huang, Zhenjiu Zhang, Zhenyu Zhao, Hui Zeng, Guangyin Yuan, Mingjun Liu","doi":"10.1021/acsbiomaterials.4c01620","DOIUrl":"10.1021/acsbiomaterials.4c01620","url":null,"abstract":"<p><p>The development of Mg and its alloys as bone screws has garnered significant attention due to their exceptional biocompatibility and unique biodegradability. Notably, the controlled release of Mg²⁺ ions during degradation can positively influence bone fracture healing. The advantages of Mg raise appeal for application in bone tissue engineering. However, porous Mg scaffolds, while offering high surface areas, face challenges in maintaining slow degradation rates and preserving interconnectivity, which are crucial features for tissue ingrowth. To address these issues, this study introduces a highly interconnected hierarchical porous Mg scaffold and investigates its degradation behavior within a bioreactor, simulating body fluid flow rates to mimic the in vivo degradation performance at different implantation sites. The focus lies on elucidating the evolution of the porous structure, particularly the impact of degradation behavior on scaffold interconnectivity. Our findings reveal that the initial high interconnectivity of the scaffold is significantly influenced by the flow rate. The dynamic fluid flow modulates the transport of degradation byproducts and the deposition patterns. At lower flow rates, Mg²⁺ ions accumulate within pores, leading to the formation of substantial deposits that directly reduce porosity. Specifically, after 42 days, porosities decreased to 68.80 ± 2.31, 58.52 ± 2.53, and 41.25 ± 2.82% at flow rates of 2.0, 1.0, and 0.5 mL/min, respectively. This porosity reduction and pore space occlusion by deposits sequentially hinder the interconnectivity. The magnitude of decreased porosity could be used to evaluate the ability of the microarchitecture to maintain scaffold interconnectivity. Meanwhile, the long-term degradation deposition behavior of the highly interconnected hierarchical porous Mg scaffold potentially revealed the structural integrity loss from the original design to its in vivo degraded structure at different body fluid flow rates. The present work might bring valuable insight into the design of pore strut and interconnectivity characterization methods for the progress of a high-performance tissue engineering scaffold.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"485-492"},"PeriodicalIF":5.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142764513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assembly of Recombinant Proteins into β-Sheet Fibrillating Peptide-Driven Supramolecular Hydrogels for Enhanced Diabetic Wound Healing.","authors":"Zhao Guo, Xing Liu, Yan Xia, Jie Wang, Jiaqi Li, Liping Wang, Yimiao Li, Shuang Jia, Yinan Sun, Jian Feng, Jingxia Huang, Yuxin Dong, Liyao Wang, Xinyu Li","doi":"10.1021/acsbiomaterials.4c01723","DOIUrl":"10.1021/acsbiomaterials.4c01723","url":null,"abstract":"<p><p>Supramolecular hydrogels offer a noncovalent binding platform that preserves the bioactivity of structural molecules while enhancing their stability, particularly in the context of diabetic wound repair. In this study, we developed protein-peptide-based supramolecular hydrogels by assembling β-sheet fibrillizing peptides (designated Q11) with β-tail fused recombinant proteins. The Q11 peptides have the ability to drive the gradated assembly of N- or C-terminal β-sheet structure (β-tail) fused recombinant proteins. We first investigated the assembly properties of Q11 and assessed its stability under varying pH and temperature conditions by combining Q11 with two β-tail fused fluorescent proteins. The results showed that Q11 enhanced the tolerance of the fluorescent proteins to changes in pH and temperature. Building upon these findings, we designed collagen-like proteins and Sonic Hedgehog-fused recombinant proteins (CLP-Shh) that could be assembled with Q11 to form peptide-protein supramolecular hydrogels. These hydrogels demonstrated the ability to improve cell viability and migration and upregulate key markers of cell growth. Further in vivo studies revealed that the Q11-driven supramolecular hydrogel effectively enhances diabetic wound healing and epidermal regeneration by promoting the expression of epidermal-related proteins and immune factors. This study highlights the potential of supramolecular hydrogels for clinical applications and their promise in the development of biofunctional hydrogels for therapeutic use.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"228-238"},"PeriodicalIF":5.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Assembled Pt/Honokiol Nanomicelles for the Treatment of Sepsis-Associated Acute Kidney Injury.","authors":"Chang Liu, Zhengjiang Cao, Li Li, Qingyin Li, Chunle Zhang, Yunbing Wang, Linhua Li, Ping Fu","doi":"10.1021/acsbiomaterials.4c01852","DOIUrl":"10.1021/acsbiomaterials.4c01852","url":null,"abstract":"<p><p>Sepsis is a severe and complex systemic infection that can result in multiple organ dysfunction. Sepsis-associated acute kidney injury (SAKI), caused by inflammatory response, oxidative stress, and cellular apoptosis, is a common complication that seriously impacts patient survival rates. Herein, a potent and novel metal-polyphenol nanomicelle can be efficiently self-assembled with Pt⁴⁺ and honokiol (HK) by the chelation, π-π conjugation, hydrophobic action, and the surfactant properties of Tween-80. These nanomicelles not only enhance drug bioavailability (encapsulation rates: Pt─49%, HK─70%) and reduce drug toxicity (safety dose: <20 μg/g) but also improve targeting toward damaged renal tissues. Furthermore, Pt⁴⁺ and HK in the nanomicelles exert a synergistic physiological effect by scavenging free radicals to alleviate oxidative damage, inhibiting macrophage activation and the release of inflammatory factors to regulate inflammation, and displaying broad-spectrum antimicrobial activity to control infection. These actions collectively protect renal tissue and restore its functionality. Here, we constructed metal-polyphenol nanomicelles (Pt/HK-NMs) via ingenious and efficient self-assembly, providing a new strategy to compensate for deficiencies in the hemodialysis and antibiotic treatment of SAKI.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"383-401"},"PeriodicalIF":5.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Uremic Toxins and Methoxy-PEO Chain Density on Plasma Protein Adsorption.","authors":"Aishwarya S Pawar, Ayda Ghahremanzadeh, Mehdi Ghaffari Sharaf, Larry D Unsworth","doi":"10.1021/acsbiomaterials.4c01407","DOIUrl":"10.1021/acsbiomaterials.4c01407","url":null,"abstract":"<p><p>Protein adsorption can direct the host response to blood-contacting biomaterials. Poly(ethylene oxide) (PEO) is commonly employed to minimize nonspecific protein adsorption. Although chain density has been observed to play a role in the inherent resistance of protein adsorption by end-tethered films of PEO, only a few papers correlate the change in PEO chain densities with the adsorbed plasma protein composition. Almost all studies rely upon blood from healthy patients for these studies even though they are applied to the unhealthy. In the case of patients with kidney failure, there is a remarkable change in the blood composition due to retained metabolites. In the pursuit of personalized dialysis, we must address this dearth in the literature regarding the effect of metabolite accumulation in the blood compartment on the adsorption of protein to blood-contacting biomaterials. To this end, surface films of different methoxy-PEO (mPEO) chain densities were used to evaluate the changes in adsorbed proteins in the presence of uremic metabolites (i.e., uremic toxins). End-tethered mPEO films were characterized using contact angles, ellipsometry, and X-ray photoelectron spectroscopy. Plasma protein adsorption was conducted with and without uremic toxins commonly found in patients with end stage kidney disease, and the adsorbed protein profile was identified using immunoblots. It was found that the presence of uremic toxins led to a notable increase in the adsorption of almost all of the proteins. It was evident that while chain density plays a role in overall protein resistance, the effect of uremic toxins led to substantial increases in adsorbed proteins and needs to be considered when designing next-generation blood-contacting materials.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"322-329"},"PeriodicalIF":5.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142764559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repair of Cartilage Defects Using ATDC5 Cells Treated with BBR Loaded in Chitosan Hydrogel.","authors":"Yixiao Chen, Guoqing Li, Yufeng Ge, Su Liu, Jian Weng, Jianjing Lin, Ao Xiong, Hui Zeng, Xinbao Wu, Jun Yang, Fei Yu","doi":"10.1021/acsbiomaterials.4c01645","DOIUrl":"10.1021/acsbiomaterials.4c01645","url":null,"abstract":"<p><p>In this study, we explore the cartilage defect repair mechanism by phosphocreatine-grafted chitosan hydrogels loaded with berberine-treated ATDC5 cells (CSMP@BBR@ATDC5). Under the optimal concentrations of LPS and BBR ideal conditions, ATDC5 cell toxicity and proliferation were detected with AM/PI and EdU staining. Additionally, qPCR and Western blot were employed to detect the expression of the SIRT1/BMP4 signaling pathway and chondrogenic-related factors in ATDC5 cells. Moreover, BBR-treated ATDC5 was seeded into a phosphocreatine-grafted chitosan hydrogel system. Subsequently, the cartilage defect was established in mice. After 4, 8, and 12 weeks, knee specimens were collected to evaluate the repair of cartilage defects. According to our findings, BBR can increase ATDC5 viability by LPS treatment. Likewise, it upregulates the SIRT1/BMP4 signaling pathway expression and chondrogenic-related factors. Another, it was shown by histological observation that the cartilage defect had been repaired more effectively in the CSMP@BBR@ATDC5 group than in the other groups. Finally, the expressions of chondrogenic-related factors and SIRT1/BMP4 signaling pathway were upregulates in CSMP@BBR@ATDC5 than in other groups. <i>In vitro,</i> BBR protects inflammatory ATDC5 cells and maintains the expression of chondrogenic-related factors. Subsequently, we successfully use CSMP@BBR@ATDC 5 to repair knee cartilage defects in mice.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"493-505"},"PeriodicalIF":5.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An In Situ UV Cross-Linking Asymmetric Adhesive Hydrogel for Noncompressible Hemostasis and Postoperative Adhesion Prevention.","authors":"Lingyuan Liu, Feng Zhao, Yiqun Zhang, Xinghui Yu, Hongjin Chen, Hui Rong, Haicheng Yuan, Jianhua Zhang, Liandong Deng, Shuangyang Li, Anjie Dong","doi":"10.1021/acsbiomaterials.4c01472","DOIUrl":"10.1021/acsbiomaterials.4c01472","url":null,"abstract":"<p><p>Noncompressible hemorrhage control is vital for clinical outcome after surgical treatment and prehospital trauma injuries. Meanwhile, wound bleeding and tissue damage could induce postoperative adhesions, leading to a severe threat to the health of patients. Considerable research had been conducted on the development of hemostatic and antiadhesive materials. However, it was still a great challenge to realize hemostasis and antiadhesion simultaneously especially in inaccessible and irregular wound sites. In this study, a kind of fluid hemostatic agent composed of gelatin methacryloyl/sulfobetaine methacrylate/oxidized konjac glucomannan (termed GOS) was developed, which spread immediately upon contacting the hepatic trauma surface and turned into hydrogels under UV radiation within 5 s, resulting in rapid hemostasis and firm adhesion to tissues (shear strength 486.08 kPa). Importantly, the surface of the as-formed GOS hydrogel exhibited lubricious and nonadhesive properties, exhibiting excellent anti-postoperative adhesion performance in a rat liver hemostasis model and a rat abdominal wall-cecum adhesion model. In addition, the GOS hydrogel reduced the postoperative secretion of inflammatory factors TNF-α and IL-6, facilitating the tissue repair. Therefore, the asymmetrical adhesive GOS hydrogel could fulfill the requirements for simultaneously rapid hemostasis, tissue adhesion, and subsequent excellent antiadhesion, which demonstrated significant potential for diverse clinical surgical operation scenarios.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"595-608"},"PeriodicalIF":5.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stat3 Induces IL-10 and SR-A/CD204 Expression in Silica Nanoparticle-Triggered Pulmonary Fibrosis through Transactivation.","authors":"Vani Mishra, Vikas Baranwal, Madhav Nilakanth Mugale, Shivesh Sharma, Rohit Kumar Mishra","doi":"10.1021/acsbiomaterials.4c01473","DOIUrl":"10.1021/acsbiomaterials.4c01473","url":null,"abstract":"<p><p>Inhalation of silica dust in the workplace has been addressed as a serious occupational pulmonary disease subsequently leading to inflammation and fibrosis. Enhanced expression of IL-10 significantly contributes to the disease etiology, along with an elevated Th2-type paradigm. Previously, we showed that the exaggerated Th2-type response was also associated with consistent upregulation of Stat3 in mouse airways stimulated with silica microparticles. However, a precise understanding of silicosis in light of the IL-10/Stat3 immune axis is required. We, therefore, aimed to determine the regulatory role of IL-10 in nanosized silica (nSiO₂)-induced pulmonary fibrosis in association with Stat3. Herein, we report that amorphous nSiO₂ could induce pulmonary fibrosis with consistent and concomitant upregulation of IL-10, Stat3, and SR-A/CD204. Following exogenous administration of siStat3 and rIL-10, the study further confirmed that Stat3 mediates the regulation of IL-10 and SR-A/CD204 and that IL-10 could regulate its own expression in an autoregulatory loop. The ChIP assay highlighted the localization of Stat3 over two putative binding sites in the IL-10 promoter region, which subsequently resulted in the overexpression of SR-A/CD204. Conclusively, Stat3-mediated transregulation of IL-10 through an autoregulatory loop in silicosis could offer novel molecular targets for therapeutic interventions.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"609-622"},"PeriodicalIF":5.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}