ACS Biomaterials Science & Engineering最新文献_第7页

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2025-06-09

Wei Meng, Ningning Li, Feng Lv, Bo Chen, Shuaijiang Lu, Jiayi Zhang, Tong Zhang, Qianyu Tao, Youlang Zhou, Limin Ma* and Yangbo Guan*,

引用次数: 0

Hard-Soft Dual-State Coatings Regulate Degradation Rate and Biocompatibility of Orthopedic Magnesium Implants. 软硬双态涂层对骨科植入体降解率和生物相容性的影响。

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2025-06-09 Epub Date: 2025-05-08 DOI: 10.1021/acsbiomaterials.4c01769

Mingming Hao, Botao Liu, Jiaqi Zhong, Yujiong Chen, Xiaodong Hu, Zhewei Zhang, Jianping Chen, Han Yu, Jiangfang Lian, Yabin Zhu, Chunhai Ke, Jingyun Ma, Zhaoxiang Peng

{"title":"Hard-Soft Dual-State Coatings Regulate Degradation Rate and Biocompatibility of Orthopedic Magnesium Implants.","authors":"Mingming Hao, Botao Liu, Jiaqi Zhong, Yujiong Chen, Xiaodong Hu, Zhewei Zhang, Jianping Chen, Han Yu, Jiangfang Lian, Yabin Zhu, Chunhai Ke, Jingyun Ma, Zhaoxiang Peng","doi":"10.1021/acsbiomaterials.4c01769","DOIUrl":"10.1021/acsbiomaterials.4c01769","url":null,"abstract":"The biomechanical similarity of magnesium to cortical bone, along with its biocompatibility and biodegradability, makes it promising for orthopedic implants. However, rapid degradation compromises the structural integrity and fixation, causing failure. To address this issue, we developed a hard-soft dual-state coating to regulate degradation and improve performance. A dense magnesium hydroxide hard coating was formed by sodium hydroxide treatment, and the hydrogel soft coating formed by freeze-drying was 44.5 μm thick. The dual coating significantly improved the corrosion resistance and mechanical properties. Mg-OH-Hy implants exhibited a reduced corrosion rate of 0.61 mm/year (±0.02), an ultimate fracture force of 750 N (±10), and a pullout force of 350 N (±10). Electrochemical testing revealed an Ecorr of -1.08 V and an Icorr of 10-3·8 mA/cm2. This dual coating approach improves mechanical stability, controls degradation, and promotes bone integration, providing personalized solutions for diverse clinical applications.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"3649-3665"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioinspired Silk and Human Amniotic Membrane-Based MSC-sEV-Functionalized Wound Dressing Enhances Skin Regeneration: A Cell-Free Therapeutic Modality for Wound Care. 仿生丝和人羊膜为基础的msc - sev功能化伤口敷料增强皮肤再生：一种无细胞的伤口护理治疗方式。

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2025-06-09 Epub Date: 2025-05-22 DOI: 10.1021/acsbiomaterials.5c00353

Shruti Mahapatra, Yashvi Sharma, Seema Kashyap, Sujata Mohanty

{"title":"Bioinspired Silk and Human Amniotic Membrane-Based MSC-sEV-Functionalized Wound Dressing Enhances Skin Regeneration: A Cell-Free Therapeutic Modality for Wound Care.","authors":"Shruti Mahapatra, Yashvi Sharma, Seema Kashyap, Sujata Mohanty","doi":"10.1021/acsbiomaterials.5c00353","DOIUrl":"10.1021/acsbiomaterials.5c00353","url":null,"abstract":"Full-thickness wounds pose significant healing challenges due to their impaired regenerative capacity, persistent inflammation, and oxidative stress. Enhancing the bioactivity of silk fibroin (SF) and the mechanical strength of the human amniotic membrane (hAM) can improve wound healing outcomes. Mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEVs) offer promising anti-inflammatory and antioxidant benefits, but their poor retention and painful application limits their clinical utility. To overcome these challenges, we developed a composite scaffold of SF and hAM (Sh), loaded with sEVs (ShE), designed to accelerate wound healing by modulating inflammation, oxidative stress, and tissue regeneration. ShE exhibited excellent physical stability, optimal swelling, degradation kinetics, hemocompatibility, and sustained sEV release. In vitro, it enhanced keratinocyte and fibroblast proliferation and migration, reduced oxidative stress, and provided immunomodulatory and pro-angiogenic effects. ShE significantly lowered ROS levels, suppressed PHA-activated PBMNC proliferation, facilitated macrophage polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype, and promoted angiogenesis. In vivo, ShE accelerated wound closure within 21 days, outperforming DuoDERM, a commercial dressing. Histopathological analysis demonstrated improved epidermal maturation, dermal regeneration, and reduced scarring in ShE-treated wounds, confirming the superior tissue regeneration capacity. Additionally, its fabrication from medical waste and indigenous raw materials ensures cost-effectiveness and sustainability in healthcare applications. By synergistically regulating cell physiology for skin regeneration, ShE emerges as a promising, clinically viable, and affordable wound dressing for enhanced wound care management.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"3597-3615"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Antimicrobial Potential of LL-37 Derivatives: Recent Developments and Challenges. 探索LL-37衍生物的抗菌潜力：最近的发展和挑战。

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2025-06-09 Epub Date: 2025-05-27 DOI: 10.1021/acsbiomaterials.4c02029

Yihao Yuan, Jiapeng Li, Guotao Wei, Ziyi Shen, Bo Li, Jiawei Wu, Jing Liu

{"title":"Exploring the Antimicrobial Potential of LL-37 Derivatives: Recent Developments and Challenges.","authors":"Yihao Yuan, Jiapeng Li, Guotao Wei, Ziyi Shen, Bo Li, Jiawei Wu, Jing Liu","doi":"10.1021/acsbiomaterials.4c02029","DOIUrl":"10.1021/acsbiomaterials.4c02029","url":null,"abstract":"The human antimicrobial peptide LL-37 exhibits broad antimicrobial efficacy. However, it has several limitations including high production costs, reduced efficacy under physiological conditions, susceptibility to proteolytic degradation and significant toxicity to human cells. Recent research has improved the clinical potential of peptide LL-37 through multiple systematic modifications. Therefore, we review the various modification techniques for LL-37 and explore the structure-activity relationships that underpin its antimicrobial properties. We also highlight the benefits of LL-37 derivatives and investigate their mechanisms of action against bacterial infections, particularly their effects on biofilms and cell membranes. Furthermore, we review the antimicrobial applications of LL-37 derivatives, examine nanocarrier systems for their delivery, and highlight the potential synergy between these derivatives and traditional antibiotics. Finally, it assesses the status of LL-37 derivatives in clinical applications, identifies ongoing challenges, and provides insights into future modifications and potential applications. This review aims to offer valuable strategies for enhancing LL-37 derivatives and facilitating their transition from laboratory research to clinical practice.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"3145-3164"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-Phase Degradation and Hydroxyapatite Formation in Bioactive Glass Ceramic-Coated Aluminum Titanate Scaffolds for Bone Applications. 生物活性玻璃陶瓷涂层钛酸铝骨支架的双相降解和羟基磷灰石形成。

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2025-06-09 Epub Date: 2025-05-28 DOI: 10.1021/acsbiomaterials.5c00048

Shanmugapriya B, Shailajha S, Sakthi Muthulakshmi S

{"title":"Dual-Phase Degradation and Hydroxyapatite Formation in Bioactive Glass Ceramic-Coated Aluminum Titanate Scaffolds for Bone Applications.","authors":"Shanmugapriya B, Shailajha S, Sakthi Muthulakshmi S","doi":"10.1021/acsbiomaterials.5c00048","DOIUrl":"10.1021/acsbiomaterials.5c00048","url":null,"abstract":"Aluminum titanium oxide scaffolds present a highly promising option because of their bioactivity, degradability, and antibacterial characteristics for bone tissue engineering. This makes them a viable alternative to metallic implants, which are susceptible to infection and have limited endurance. The present work aims to examine the impact of sol-gel bioactive glass ceramic coatings on Al2TiO5 pellets throughout immersion periods of 12 and 24 h (BG12, BG24). A dual-phase degradation process occurs in these coated scaffolds: first, ion release from the coating stimulates the creation of hydroxyapatite, followed by a progressive breakdown of the Al2TiO5 substrate, which further facilitates bone regeneration. An analysis of the structural and mechanical characteristics of coated and uncoated pellets was conducted by utilizing FESEM-EDS, XRD, TG-DTA, FTIR, BET, AFM, and micro-UTM techniques. Findings indicated that the scaffolds consist of a crystalline component of calcium magnesium silicate and calcium sodium aluminum silicate, together with a porous surface. Among the scaffolds, BG24 had the greatest compressive strength of 101 MPa. Bioactivity investigations demonstrated the production of hydroxyapatite in SBF, with a calcium-to-phosphorus ratio of 1.68 attained by BG24 after 14 days. Moreover, BG24 showed 90% cell survival at 100 μg mL-1, so verifying its cytocompatibility based on biocompatibility and antibacterial tests. Antibacterial research also showed that it effectively stopped the growth of S. aureus and E. coli bacteria, which supports the idea that it might be able to lower the risk of infections in biomedical settings. Because of its improved bioactivity through a dual-phase degradation mechanism, BG24 is a promising option for bone tissue regeneration.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"3330-3350"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spray Drying of Regenerated Silk: Understanding and Controlling Particle Size and Solubility. 再生丝的喷雾干燥：了解和控制粒度和溶解度。

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2025-06-09 Epub Date: 2025-05-28 DOI: 10.1021/acsbiomaterials.5c00600

Illa Tewari, Martin Zaki, David A V Morton, Rangam Rajkhowa, Benjamin J Allardyce

{"title":"Spray Drying of Regenerated Silk: Understanding and Controlling Particle Size and Solubility.","authors":"Illa Tewari, Martin Zaki, David A V Morton, Rangam Rajkhowa, Benjamin J Allardyce","doi":"10.1021/acsbiomaterials.5c00600","DOIUrl":"10.1021/acsbiomaterials.5c00600","url":null,"abstract":"This study demonstrates the use of spray drying as a versatile processing technique to produce regenerated silk powders with a controllable particle size and solubility. After overcoming silk's shear sensitivity and establishing a usable processing window, semicrystalline silk powders were produced. The impact of silk properties and spray drying conditions on powder properties was then explored. Spray drying produced spherical hollow or collapsed particles similar to other spray dried proteins; particle size could be controlled from a d(50) of less than 5 to almost 40 μm through altering feedstock concentration. Interestingly, the silk secondary structure, which typically dictates silk solubility, was resilient to changes in spray drying conditions: all powder samples ranged from 39 to 42% β-sheet content. Yet despite these findings, silk solubility could be controlled from less than 4% to nearly 60% purely by changing fibroin molecular weight and, to a lesser extent, concentration. Given the commercial viability of spray drying, this study demonstrates significant potential for the production of powders with controllable properties for a range of possible applications, from biomaterials to food or cosmetic applications.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"3389-3399"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-Time in Vivo Bacterial Imaging by Computed Tomography and Fluorescence Using Phage-Gold Nanorod Bioconjugates as Contrast Agents. 利用噬菌体金纳米棒生物偶联物作为造影剂的实时体内细菌ct和荧光成像。

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2025-06-09 Epub Date: 2025-05-08 DOI: 10.1021/acsbiomaterials.4c02190

Huan Peng, Shelby Vexler, Shili Xu, Irene A Chen

{"title":"Real-Time in Vivo Bacterial Imaging by Computed Tomography and Fluorescence Using Phage-Gold Nanorod Bioconjugates as Contrast Agents.","authors":"Huan Peng, Shelby Vexler, Shili Xu, Irene A Chen","doi":"10.1021/acsbiomaterials.4c02190","DOIUrl":"10.1021/acsbiomaterials.4c02190","url":null,"abstract":"Real-time in vivo imaging of bacterial infections is an important goal to aid the study and treatment of bacterial infections. Phages can be genetically engineered to ensure a particular biomolecular target specificity, and gold nanomaterials can be conjugated to phages for a variety of applications including biosensing. In this paper, we describe methods to use phage-gold nanorod conjugates for in vivo detection and imaging of the bacterial species Pseudomonas aeruginosa in mice. The imaging modalities are computed tomography (CT), using gold as a contrast agent, and fluorescence, which can be applied when the FDA-approved near-infrared (NIR) dye indocyanine green (ICG) is also chemically cross-linked to the bioconjugates. In addition, rapid protocols for validating bioconjugate synthesis and the initial assessment of toxicity are given. In this example, the phage-gold nanorod probe is shown to specifically highlight P. aeruginosa without cross-reactivity to another Gram-negative organism (V. cholerae) in vivo and appears to be biocompatible. Phage-directed imaging probes may thus be useful for the characterization and diagnosis of bacterial infections.","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"3297-3306"},"PeriodicalIF":5.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2025-06-09

Yeongeun Kim, Sudip Mondal, Hwarang Shin, Soonhyuk Tak, Vu Hoang Minh Doan, Junghwan Oh* and Hyun Wook Kang*,

引用次数: 0

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2025-06-09

Xin Su, Mingqi Wang, Ruqiang Yuan, Lina Guo, Yinhe Han, Chun Huang, Ang Li, David L. Kaplan and Xiuli Wang*,

引用次数: 0

IF 5.4 2区医学

ACS Biomaterials Science & Engineering Pub Date : 2025-06-09

Miguel S. Rocha, Catarina F. Marques, Sandra Pina, Joaquim M. Oliveira, Rui L. Reis and Tiago H. Silva*,

引用次数: 0