{"title":"软硬双态涂层对骨科植入体降解率和生物相容性的影响。","authors":"Mingming Hao, Botao Liu, Jiaqi Zhong, Yujiong Chen, Xiaodong Hu, Zhewei Zhang, Jianping Chen, Han Yu, Jiangfang Lian, Yabin Zhu, Chunhai Ke, Jingyun Ma, Zhaoxiang Peng","doi":"10.1021/acsbiomaterials.4c01769","DOIUrl":null,"url":null,"abstract":"<p><p>The biomechanical similarity of magnesium to cortical bone, along with its biocompatibility and biodegradability, makes it promising for orthopedic implants. However, rapid degradation compromises the structural integrity and fixation, causing failure. To address this issue, we developed a hard-soft dual-state coating to regulate degradation and improve performance. A dense magnesium hydroxide hard coating was formed by sodium hydroxide treatment, and the hydrogel soft coating formed by freeze-drying was 44.5 μm thick. The dual coating significantly improved the corrosion resistance and mechanical properties. Mg-OH-Hy implants exhibited a reduced corrosion rate of 0.61 mm/year (±0.02), an ultimate fracture force of 750 N (±10), and a pullout force of 350 N (±10). Electrochemical testing revealed an <i>E</i><sub>corr</sub> of -1.08 V and an <i>I</i><sub>corr</sub> of 10<sup>-3·8</sup> mA/cm<sup>2</sup>. This dual coating approach improves mechanical stability, controls degradation, and promotes bone integration, providing personalized solutions for diverse clinical applications.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"3649-3665"},"PeriodicalIF":5.5000,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hard-Soft Dual-State Coatings Regulate Degradation Rate and Biocompatibility of Orthopedic Magnesium Implants.\",\"authors\":\"Mingming Hao, Botao Liu, Jiaqi Zhong, Yujiong Chen, Xiaodong Hu, Zhewei Zhang, Jianping Chen, Han Yu, Jiangfang Lian, Yabin Zhu, Chunhai Ke, Jingyun Ma, Zhaoxiang Peng\",\"doi\":\"10.1021/acsbiomaterials.4c01769\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The biomechanical similarity of magnesium to cortical bone, along with its biocompatibility and biodegradability, makes it promising for orthopedic implants. However, rapid degradation compromises the structural integrity and fixation, causing failure. To address this issue, we developed a hard-soft dual-state coating to regulate degradation and improve performance. A dense magnesium hydroxide hard coating was formed by sodium hydroxide treatment, and the hydrogel soft coating formed by freeze-drying was 44.5 μm thick. The dual coating significantly improved the corrosion resistance and mechanical properties. Mg-OH-Hy implants exhibited a reduced corrosion rate of 0.61 mm/year (±0.02), an ultimate fracture force of 750 N (±10), and a pullout force of 350 N (±10). Electrochemical testing revealed an <i>E</i><sub>corr</sub> of -1.08 V and an <i>I</i><sub>corr</sub> of 10<sup>-3·8</sup> mA/cm<sup>2</sup>. This dual coating approach improves mechanical stability, controls degradation, and promotes bone integration, providing personalized solutions for diverse clinical applications.</p>\",\"PeriodicalId\":8,\"journal\":{\"name\":\"ACS Biomaterials Science & Engineering\",\"volume\":\" \",\"pages\":\"3649-3665\"},\"PeriodicalIF\":5.5000,\"publicationDate\":\"2025-06-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Biomaterials Science & Engineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1021/acsbiomaterials.4c01769\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/5/8 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Biomaterials Science & Engineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1021/acsbiomaterials.4c01769","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/8 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Hard-Soft Dual-State Coatings Regulate Degradation Rate and Biocompatibility of Orthopedic Magnesium Implants.
The biomechanical similarity of magnesium to cortical bone, along with its biocompatibility and biodegradability, makes it promising for orthopedic implants. However, rapid degradation compromises the structural integrity and fixation, causing failure. To address this issue, we developed a hard-soft dual-state coating to regulate degradation and improve performance. A dense magnesium hydroxide hard coating was formed by sodium hydroxide treatment, and the hydrogel soft coating formed by freeze-drying was 44.5 μm thick. The dual coating significantly improved the corrosion resistance and mechanical properties. Mg-OH-Hy implants exhibited a reduced corrosion rate of 0.61 mm/year (±0.02), an ultimate fracture force of 750 N (±10), and a pullout force of 350 N (±10). Electrochemical testing revealed an Ecorr of -1.08 V and an Icorr of 10-3·8 mA/cm2. This dual coating approach improves mechanical stability, controls degradation, and promotes bone integration, providing personalized solutions for diverse clinical applications.
期刊介绍：
ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics:
Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology
Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions
Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis
Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering
Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends
Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring
Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration
Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials
Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture
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