Innovations in Core-Shell Electrospinning: A Comprehensive Review in Recent Advances of Core-Shell Electrospun Polylactic Acid Nanocomposite Fibers for Potential Biomedical Applications.

IF 5.4 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Biomaterials Science & Engineering Pub Date : 2025-06-16 DOI:10.1021/acsbiomaterials.5c00194

B Akhila, V Abhijith, Mridula Sreedharan, Lakshmipriya Ravindran, Aiswarya Sathian, Sabu Thomas, Sreekala Meyyarappallil Sadasivan

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Abstract

The unique structural and functional properties of polylactic acid (PLA) nanofibers, particularly in core-shell structures, have placed them as a crucial material in biomedical engineering. In addition to its renewable characteristics, biodegradability, and biocompatibility, PLA distinguishes itself and satisfies the increasing demand for environmentally friendly and sustainable materials in medical applications. It is an optimal material for scaffolds, implants, and biomedical devices due to its adjustable mechanical strength, degradation rate, excellent biocompatibility, and capacity to form intricate fiber architectures. The precise manipulation of PLA nanofibers can be made easier by advanced electrospinning techniques, which maintain the structural integrity of the PLA nanofibers while allowing for the encapsulation with controlled release of bioactive compounds. The core-shell architectures enhance mechanical performance, cellular adhesion, and proliferation, making them suitable for various advanced biomedical applications. Moreover, PLA degradation products have a much lower environmental effect compared to other synthetic nondegradable polymers, signifying a substantial advantage. The review article covers the techniques used for the fabrication of coaxial electrospun PLA nanofibers, their benefits, and potential uses in innovative healthcare products and sustainable biomedical practices.

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核-壳静电纺丝技术的创新：核-壳静电纺丝聚乳酸纳米复合纤维生物医学研究进展综述

聚乳酸（PLA）纳米纤维独特的结构和功能特性，特别是核壳结构，使其成为生物医学工程中的重要材料。PLA除了具有可再生特性、生物降解性和生物相容性外，还使其脱颖而出，满足了医疗应用中对环保和可持续材料日益增长的需求。由于其可调节的机械强度、降解率、优异的生物相容性和形成复杂纤维结构的能力，它是支架、植入物和生物医学设备的最佳材料。先进的静电纺丝技术可以使PLA纳米纤维的精确操作变得更加容易，该技术可以保持PLA纳米纤维的结构完整性，同时允许包被生物活性化合物的可控释放。核壳结构增强机械性能，细胞粘附和增殖，使其适合各种先进的生物医学应用。此外，与其他合成的不可降解聚合物相比，PLA降解产物的环境影响要低得多，这表明它具有很大的优势。本文综述了同轴静电纺聚乳酸纳米纤维的制备技术、优点以及在创新医疗保健产品和可持续生物医学实践中的潜在应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Biomaterials Science & Engineering Materials Science-Biomaterials

CiteScore

10.30

自引率

3.40%

发文量

413

期刊介绍： ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics: Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture