Case reports in nephrology and urology最新文献_第6页

Renal cell carcinoma in the allograft: what is the role of polyomavirus? 移植肾细胞癌:多瘤病毒的作用是什么?

Case reports in nephrology and urology Pub Date : 2012-07-01 Epub Date: 2012-09-05 DOI: 10.1159/000341917

Valerie Neirynck, Kathleen Claes, Maarten Naesens, Liesbeth De Wever, Jacques Pirenne, Dirk Kuypers, Yves Vanrenterghem, Hendrik Van Poppel, Andre Kabanda, Evelyne Lerut

{"title":"Renal cell carcinoma in the allograft: what is the role of polyomavirus?","authors":"Valerie Neirynck, Kathleen Claes, Maarten Naesens, Liesbeth De Wever, Jacques Pirenne, Dirk Kuypers, Yves Vanrenterghem, Hendrik Van Poppel, Andre Kabanda, Evelyne Lerut","doi":"10.1159/000341917","DOIUrl":"https://doi.org/10.1159/000341917","url":null,"abstract":"BK virus (BKV) is known to cause subclinical infection in childhood. The virus remains latent in the human body, mainly in the urinary tract epithelium. After initiation of an immunosuppressive treatment, reactivation can occur in renal transplant recipients. BKV can cause hemorrhagic cystitis, ureteral stenosis and BKV nephropathy in immunocompromised patients. Furthermore, a number of case reports suggest an association between BKV infection and the development of urinary tract cancer. So far, an oncogenic potential of BKV has been observed in vitro and in animal models; however, its oncogenic capacity in humans remains unclear. We report the case of a 59-year-old patient who developed a poorly differentiated renal cell carcinoma in her renal allograft, with pulmonary and abdominal metastasis. Surgical removal of the allograft and cessation of the immunosuppressive therapy resulted in complete resolution of the metastatic disease.","PeriodicalId":89663,"journal":{"name":"Case reports in nephrology and urology","volume":"2 2","pages":"125-34"},"PeriodicalIF":0.0,"publicationDate":"2012-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000341917","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31084256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Rituximab Treatment for PR3-ANCA-Positive Membranoproliferative Glomerulonephritis Associated with Adult-Onset Periodic Fever Syndrome. 利妥昔单抗治疗pr3 - anca阳性膜增生性肾小球肾炎伴成年性发热综合征

Case reports in nephrology and urology Pub Date : 2012-07-01 Epub Date: 2012-07-11 DOI: 10.1159/000341192

Yoshitomo Hamano, Hiromichi Yoshizawa, Taro Sugase, Takuya Miki, Naoko Ohtani, Shiho Hanawa, Eri Takeshima, Yoshiyuki Morishita, Osamu Saito, Fumi Takemoto, Shigeaki Muto, Wako Yumura, Eiji Kusano

{"title":"Rituximab Treatment for PR3-ANCA-Positive Membranoproliferative Glomerulonephritis Associated with Adult-Onset Periodic Fever Syndrome.","authors":"Yoshitomo Hamano, Hiromichi Yoshizawa, Taro Sugase, Takuya Miki, Naoko Ohtani, Shiho Hanawa, Eri Takeshima, Yoshiyuki Morishita, Osamu Saito, Fumi Takemoto, Shigeaki Muto, Wako Yumura, Eiji Kusano","doi":"10.1159/000341192","DOIUrl":"https://doi.org/10.1159/000341192","url":null,"abstract":"We report the case of a 36-year-old Japanese woman with nephrotic syndrome due to membranoproliferative glomerulonephritis (MPGN) Type I diagnosed after a 5-year history of periodic fever syndrome (PFS). Hypocomplementemia and elevation of anti-proteinase 3 anti-neutrophil cytoplasmic autoantibody (PR3-ANCA) were observed. HIV, and hepatitis B and C serology were negative. Nephrotic syndrome and periodic fever did not respond to oral steroid and intravenous steroid pulse therapies combined with cyclosporine, dipyridamole, warfarin and losartan. We tried immunotherapy using rituximab, a human-mouse chimeric monoclonal antibody directed against the CD20 antigen on mature B cells. This therapeutic approach led to improvement of renal function and remission of nephrotic syndrome and hypocomplementemia. However, it did not have a beneficial effect on periodic fever. Suspecting adult-onset hereditary PFS, we analyzed her genetic alteration of MEFV and TNFRSF1A genes. A rare genotype in intron 6 of TNFRSF1A was revealed. The etiological relationship between periodic fever and MPGN is discussed. Rituximab is a hopeful choice of induction therapy for refractory MPGN.","PeriodicalId":89663,"journal":{"name":"Case reports in nephrology and urology","volume":"2 2","pages":"92-101"},"PeriodicalIF":0.0,"publicationDate":"2012-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000341192","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31086513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Sarcoma-like pyogenic granuloma of the thumb and respiratory restrictive syndrome in a non-compliant hemodialysis patient. 不依从性血液透析患者的拇指肉瘤样化脓性肉芽肿与呼吸限制综合征。

Case reports in nephrology and urology Pub Date : 2012-07-01 Epub Date: 2012-11-08 DOI: 10.1159/000345281

Isabelle Simon, Pierre Alain Gevenois, Véronique Del Marmol, Wissam El Kazzi, Anne-Laure Trepant, Karine Gastaldello, Joëlle L Nortier

引用次数: 0

Seasonal relapsing minimal change disease: a novel strategy for avoiding long-term immunosuppression. 季节性复发性微小变化疾病:避免长期免疫抑制的新策略。

Case reports in nephrology and urology Pub Date : 2012-07-01 Epub Date: 2012-07-24 DOI: 10.1159/000341257

Christopher Lawrence, H Terry Cook, Liz Lightstone

{"title":"Seasonal relapsing minimal change disease: a novel strategy for avoiding long-term immunosuppression.","authors":"Christopher Lawrence, H Terry Cook, Liz Lightstone","doi":"10.1159/000341257","DOIUrl":"https://doi.org/10.1159/000341257","url":null,"abstract":"Background: We describe the case of a young woman with seasonal allergic rhinitis who presented with signs of a lower respiratory tract infection, acute renal impairment and the nephrotic syndrome, demonstrated on biopsy to be due to minimal change disease (MCD) with acute tubular injury. Following initiation of high-dose corticosteroids, her respiratory symptoms and renal impairment improved, and the nephrotic syndrome went rapidly into remission, but relapsed, off treatment, in a seasonal fashion.Management: In view of significant side effects related to corticosteroids, relapses were treated with the calcineurin inhibitor tacrolimus with excellent effect, but the patient was keen to avoid the complications of medium-term immunosuppression and so the drug was weaned early. She relapsed for the second time, whilst off tacrolimus, at the same time of year as at her initial presentation. In subsequent years we have successfully managed this patient with seasonal relapsing MCD with seasonal prophylactic tacrolimus therapy.Discussion: We discuss the natural history of MCD and treatment options and demonstrate the utility of a clear understanding of the natural history of the condition in order to predict disease relapse and tailor therapy to the individual patient.","PeriodicalId":89663,"journal":{"name":"Case reports in nephrology and urology","volume":"2 2","pages":"102-7"},"PeriodicalIF":0.0,"publicationDate":"2012-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000341257","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31086514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Campylobacter bacteremia in hemodialysis patients by eating raw meat - the importance of sanitary education. 血液透析患者吃生肉引起弯曲杆菌菌血症——卫生教育的重要性。

Case reports in nephrology and urology Pub Date : 2012-07-01 Epub Date: 2012-10-24 DOI: 10.1159/000343499

Yoshio Shimizu, Arisa Ishii, Akiko Takahata, Tadahiro Kajiyama, Aya Yamahatsu, Hiroaki Io, Atsushi Kurusu, Chieko Hamada, Satoshi Horikoshi, Yasuhiko Tomino

引用次数: 10

A case of diffuse endocapillary proliferative glomerulonephritis associated with polymyalgia rheumatica. 弥漫性毛细血管内增生性肾小球肾炎伴风湿性多肌痛1例。

Case reports in nephrology and urology Pub Date : 2012-07-01 Epub Date: 2012-11-15 DOI: 10.1159/000345280

Eri Takeshima, Yoshiyuki Morishita, Manabu Ogura, Chiharu Ito, Osamu Saito, Fumi Takemoto, Yasuhiro Ando, Shigeaki Muto, Wako Yumura, Eiji Kusano

引用次数: 3

Seminoma in the testis presenting as hemospermia. 睾丸精原细胞瘤表现为血精症。

Case reports in nephrology and urology Pub Date : 2012-07-01 Epub Date: 2012-09-19 DOI: 10.1159/000343245

Sami Beji, Martin Hoejgaard, Peter Lyngdorf

引用次数: 4

Low-grade fibromyxoid sarcoma of the renal pelvis: first report. 肾盂低度纤维黏液样肉瘤:首次报告。

Case reports in nephrology and urology Pub Date : 2012-07-01 Epub Date: 2012-07-10 DOI: 10.1159/000341191

Aristeidis Alevizopoulos, Vasilis Mygdalis, Stayros Tyritzis, K Stravodimos, Constantinos A Constantinides

引用次数: 16

Relapsing acute kidney injury associated with pegfilgrastim. 聚非格昔汀对复发性急性肾损伤的影响。

Case reports in nephrology and urology Pub Date : 2012-07-01 Epub Date: 2012-11-21 DOI: 10.1159/000345278

Swati Arora, Arpit Bhargava, Katherine Jasnosz, Barbara Clark

{"title":"Relapsing acute kidney injury associated with pegfilgrastim.","authors":"Swati Arora, Arpit Bhargava, Katherine Jasnosz, Barbara Clark","doi":"10.1159/000345278","DOIUrl":"https://doi.org/10.1159/000345278","url":null,"abstract":"We report a previously unrecognized complication of severe acute kidney injury (AKI) after the administration of pegfilgrastim with biopsy findings of mesangioproliferative glomerulonephritis (GN) and tubular necrosis. A 51-year-old white female with a history of breast cancer presented to the hospital with nausea, vomiting and dark urine 2 weeks after her third cycle of cyclophosphamide and docetaxel along with pegfilgrastim. She was found to have AKI with a serum creatinine (Cr) level of 6.9 mg/dl (baseline 0.7). At that time, her AKI was believed to be related to prior sepsis and/or daptomycin exposure that had occurred 5 weeks earlier. She was dialyzed for 6 weeks, after which her kidney function recovered to near baseline, but her urinalysis (UA) still showed 3.5 g protein/day and dysmorphic hematuria. Repeat blood cultures and serological workup (complement levels, hepatitis panel, ANA, ANCA and anti-GBM) were negative. She received her next cycle of chemotherapy with the same drugs. Two weeks later, she developed recurrent AKI with a Cr level of 6.7 mg/dl. A kidney biopsy showed mesangioproliferative GN, along with tubular epithelial damage and a rare electron-dense glomerular deposit. Pegfilgrastim was suspected as the inciting agent after exclusion of other causes. Her Cr improved to 1.4 mg/dl over the next 3 weeks, this time without dialysis. She had the next 2 cycles of chemotherapy without pegfilgrastim, with no further episodes of AKI. A literature review revealed a few cases of a possible association of filgrastim with mild self-limited acute GN. In conclusion, pegfilgrastim may cause GN with severe AKI. Milder cases may be missed and therefore routine monitoring of renal function and UA is important.","PeriodicalId":89663,"journal":{"name":"Case reports in nephrology and urology","volume":"2 2","pages":"165-71"},"PeriodicalIF":0.0,"publicationDate":"2012-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000345278","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31167091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Ureteroscopy-assisted retrograde nephrostomy for percutaneous nephrolithotomy after urinary diversion. 输尿管镜辅助逆行肾造瘘在经皮肾镜取石术中的应用。

Case reports in nephrology and urology Pub Date : 2012-07-01 Epub Date: 2012-08-29 DOI: 10.1159/000342338

Takashi Kawahara, Hiroki Ito, Hideyuki Terao, Takehiko Ogawa, Hiroji Uemura, Yoshinobu Kubota, Junichi Matsuzaki

引用次数: 9