Bioscience trends最新文献_第4页

High-frequency hearing vulnerability associated with the different supporting potential of Hensen's cells: SMART-Seq2 RNA sequencing. 高频听力损伤与 Hensen 细胞的不同支持潜能有关：SMART-Seq2 RNA测序。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-04-05 DOI: 10.5582/bst.2024.01044

Yiding Yu, Yueping Li, C. Wen, Fengbo Yang, Xuemin Chen, Wenqi Yi, Lin Deng, Xiaohua Cheng, Ning Yu, Lihui Huang

{"title":"High-frequency hearing vulnerability associated with the different supporting potential of Hensen's cells: SMART-Seq2 RNA sequencing.","authors":"Yiding Yu, Yueping Li, C. Wen, Fengbo Yang, Xuemin Chen, Wenqi Yi, Lin Deng, Xiaohua Cheng, Ning Yu, Lihui Huang","doi":"10.5582/bst.2024.01044","DOIUrl":"https://doi.org/10.5582/bst.2024.01044","url":null,"abstract":"Hearing loss is the third most prevalent physical condition affecting communication, well-being, and healthcare costs. Sensorineural hearing loss often occurs first in the high-frequency region (basal turn), then towards the low-frequency region (apical turn). However, the mechanism is still unclear. Supporting cells play a critical role in the maintenance of normal cochlear function. The function and supporting capacity of these cells may be different from different frequency regions. Hensen's cells are one of the unique supporting cell types characterized by lipid droplets (LDs) in the cytoplasm. Here, we investigated the morphological and gene expression differences of Hensen's cells along the cochlear axis. We observed a gradient change in the morphological characteristics of Hensen's cells along the cochlear tonotopic axis, with larger and more abundant LDs observed in apical Hensen's cells. Smart-seq2 RNA-seq revealed differentially expressed genes (DEGs) between apical and basal Hensen's cells that clustered in several pathways, including unsaturated fatty acid biosynthesis, cholesterol metabolism, and fatty acid catabolism, which are associated with different energy storage capacities and metabolic potential. These findings suggest potential differences in lipid metabolism and oxidative energy supply between apical and basal Hensen's cells, which is consistent with the morphological differences of Hensen's cells. We also found differential expression patterns of candidate genes associated with hereditary hearing loss (HHL), noise-induced hearing loss (NIHL), and age-related hearing loss (ARHL). These findings indicate functional heterogeneity of SCs along the cochlear axis, contribute to our understanding of cochlear physiology and provide molecular basis evidence for future studies of hearing loss.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140740537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of transcatheter arterial chemoembolization combined with lenvatinib plus anti-PD-1 antibodies in patients with unresectable hepatocellular carcinoma: A treatment with Chinese characteristics. 经导管动脉化疗栓塞联合来伐替尼+抗PD-1抗体治疗不可切除肝细胞癌的效果：一种具有中国特色的治疗方法

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-03-19 Epub Date: 2024-02-08 DOI: 10.5582/bst.2023.01326

Jiayi Wu, Junyi Wu, Shuqun Li, Mengchao Luo, Zhenxin Zeng, Yinan Li, Yangkai Fu, Han Li, Deyi Liu, Xiangye Ou, Zhongtai Lin, Shaoming Wei, Maolin Yan

{"title":"Effect of transcatheter arterial chemoembolization combined with lenvatinib plus anti-PD-1 antibodies in patients with unresectable hepatocellular carcinoma: A treatment with Chinese characteristics.","authors":"Jiayi Wu, Junyi Wu, Shuqun Li, Mengchao Luo, Zhenxin Zeng, Yinan Li, Yangkai Fu, Han Li, Deyi Liu, Xiangye Ou, Zhongtai Lin, Shaoming Wei, Maolin Yan","doi":"10.5582/bst.2023.01326","DOIUrl":"10.5582/bst.2023.01326","url":null,"abstract":"Therapies for patients with unresectable hepatocellular carcinoma (uHCC) are currently popular. Current first-line standard-of-care treatments for uHCC are systematic therapies. However, treatments that combine locoregional therapy with systemic therapy are widely accepted in China and have demonstrated high rates of tumor response and conversion to resection with manageable toxicity. A literature review was performed by searching published literature in PubMed and Web of Science up to December 2023 for relevant articles on the use of triple therapy (transarterial chemoembolization combined with lenvatinib and anti-PD-1 antibodies) in uHCC. This review concentrates on the efficacy and safety of triple therapy with Chinese characteristics in patients with uHCC and describes the outcome of conversion surgery, degree of pathological necrosis, and effect prediction. This article will contribute to a comprehensive understanding of the role of triple therapy with Chinese characteristics in patients with uHCC.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139701742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monoclonal antibody therapy for Alzheimer's disease focusing on intracerebral targets. 以脑内靶点为重点的阿尔茨海默病单克隆抗体疗法。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-03-19 Epub Date: 2024-02-21 DOI: 10.5582/bst.2023.01288

Xiaolei Gu, Long Qi, Qing Qi, Jing Zhou, Song Chen, Ling Wang

引用次数: 0

Roadmap for ending TB in China by 2035: The challenges and strategies. 到 2035 年在中国消除结核病的路线图：挑战与战略。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-03-19 Epub Date: 2024-02-08 DOI: 10.5582/bst.2023.01325

Qishun Feng, Guoliang Zhang, Liang Chen, Huizhong Wu, Yingzhou Yang, Qian Gao, Tetsuya Asakawa, Yanlin Zhao, Shuihua Lu, Lin Zhou, Hongzhou Lu

引用次数: 0

New mechanisms: From lactate to lactylation to rescue heart failure. 新机制：从乳酸到乳化，拯救心力衰竭。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-03-19 Epub Date: 2024-02-08 DOI: 10.5582/bst.2024.01000

Linfeng Yi, Dan Tang, Xing Xiang, Chungang Xiao, Huifang Tang, Hong Huang

引用次数: 0

Predictive deep learning models for cognitive risk using accessible data. 利用可获取的数据建立认知风险预测深度学习模型。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-03-19 Epub Date: 2024-02-20 DOI: 10.5582/bst.2024.01026

Kenji Karako

引用次数: 0

Neoadjuvant therapies in resectable hepatocellular carcinoma: Exploring strategies to improve prognosis. 可切除肝细胞癌的新辅助疗法：探索改善预后的策略。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-03-19 Epub Date: 2024-02-20 DOI: 10.5582/bst.2023.01436

Ya-Nan Ma, Xuemei Jiang, Peipei Song, Wei Tang

{"title":"Neoadjuvant therapies in resectable hepatocellular carcinoma: Exploring strategies to improve prognosis.","authors":"Ya-Nan Ma, Xuemei Jiang, Peipei Song, Wei Tang","doi":"10.5582/bst.2023.01436","DOIUrl":"10.5582/bst.2023.01436","url":null,"abstract":"Hepatocellular carcinoma (HCC), a challenging malignancy, often necessitates surgical intervention, notably liver resection. However, the high recurrence rate, reaching 70% within 5 years post-resection, significantly impacts patient outcomes. Neoadjuvant therapies aim to preoperatively address this challenge, reducing lesion size, improving surgical resection rates, deactivating potential micro-metastases, and ultimately lowering postoperative recurrence rates. This review concentrates on advances in research on and clinical use of neoadjuvant therapies for HCC, with particular attention to the use of immune checkpoint inhibitors (ICIs) targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte-associated protein-4 (CTLA-4). Ongoing clinical studies exploring immunotherapy combined with a tyrosine kinase inhibitor (TKI), interventional therapy, radiotherapy, and other modalities offer promising insights into overcoming resistance to monotherapies. In summary, neoadjuvant therapies hold significant promise in terms of improving the prognosis for patients with HCC and enhancing long-term survival, particularly through innovative combination strategies.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139929931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automated machine learning-based model for the prediction of pedicle screw loosening after degenerative lumbar fusion surgery. 基于机器学习的椎弓根螺钉松动自动预测模型，用于预测退行性腰椎融合手术后的椎弓根螺钉松动。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-03-19 Epub Date: 2024-02-27 DOI: 10.5582/bst.2023.01327

Feng Jiang, Xinxin Li, Lei Liu, Zhiyang Xie, Xiaotao Wu, Yuntao Wang

{"title":"Automated machine learning-based model for the prediction of pedicle screw loosening after degenerative lumbar fusion surgery.","authors":"Feng Jiang, Xinxin Li, Lei Liu, Zhiyang Xie, Xiaotao Wu, Yuntao Wang","doi":"10.5582/bst.2023.01327","DOIUrl":"10.5582/bst.2023.01327","url":null,"abstract":"The adequacy of screw anchorage is a critical factor in achieving successful spinal fusion. This study aimed to use machine learning algorithms to identify critical variables and predict pedicle screw loosening after degenerative lumbar fusion surgery. A total of 552 patients who underwent primary transpedicular lumbar fixation for lumbar degenerative disease were included. The LASSO method identified key features associated with pedicle screw loosening. Patient clinical characteristics, intraoperative variables, and radiographic parameters were collected and used to construct eight machine learning models, including a training set (80% of participants) and a test set (20% of participants). The XGBoost model exhibited the best performance, with an AUC of 0.884 (95% CI: 0.825-0.944) in the test set, along with the lowest Brier score. Ten crucial variables, including age, disease diagnosis: degenerative scoliosis, number of fused levels, fixation to S1, HU value, preoperative PT, preoperative PI-LL, postoperative LL, postoperative PT, and postoperative PI-LL were selected. In the prospective cohort, the XGBoost model demonstrated substantial performance with an accuracy of 83.32%. This study identified crucial variables associated with pedicle screw loosening after degenerative lumbar fusion surgery and successfully developed a machine learning model to predict pedicle screw loosening. The findings of this study may provide valuable information for clinical decision-making.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139989261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetes mellitus, glycemic traits, SGLT2 inhibition, and risk of pulmonary arterial hypertension: A Mendelian randomization study. 糖尿病、血糖特征、SGLT2 抑制与肺动脉高压风险：孟德尔随机研究

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-03-19 Epub Date: 2024-02-08 DOI: 10.5582/bst.2024.01006

Jiang-Shan Tan, Yanmin Yang, Jingyang Wang, Yimeng Wang, Tingting Lv, Yuyuan Shu, Wei Xu, Lingtao Chong

{"title":"Diabetes mellitus, glycemic traits, SGLT2 inhibition, and risk of pulmonary arterial hypertension: A Mendelian randomization study.","authors":"Jiang-Shan Tan, Yanmin Yang, Jingyang Wang, Yimeng Wang, Tingting Lv, Yuyuan Shu, Wei Xu, Lingtao Chong","doi":"10.5582/bst.2024.01006","DOIUrl":"10.5582/bst.2024.01006","url":null,"abstract":"This study aimed to investigate the causal role of diabetes mellitus (DM), glycemic traits, and sodium-glucose cotransporter 2 (SGLT2) inhibition in pulmonary arterial hypertension (PAH). Utilizing a two-sample two-step Mendelian randomization (MR) approach, we determined the causal influence of DM and glycemic traits (including insulin resistance, glycated hemoglobin, and fasting insulin and glucose) on the risk of PAH. Moreover, we examined the causal effects of SGLT2 inhibition on the risk of PAH. Genetic proxies for SGLT2 inhibition were identified as variants in the SLC5A2 gene that were associated with both levels of gene expression and hemoglobin A1c. Results showed that genetically inferred DM demonstrated a causal correlation with an increased risk of PAH, exhibiting an odds ratio (OR) of 1.432, with a 95% confidence interval (CI) of 1.040-1.973, and a p-value of 0.028. The multivariate MR analysis revealed comparable outcomes after potential confounders (OR = 1.469, 95%CI = 1.021-2.115, p = 0.038). Moreover, genetically predicted SGLT2 inhibition was causally linked to a reduced risk of PAH (OR = 1.681*10-7, 95%CI = 7.059*10-12-0.004, p = 0.002). Therefore, our study identified the suggestively causal effect of DM on the risk of PAH, and SGLT2 inhibition may be a potential therapeutic target in patients with PAH.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139701741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Socioeconomic disparities in education placement for children of primary school age with autism spectrum disorder in China. 中国小学学龄自闭症谱系障碍儿童教育安置的社会经济差异。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-03-19 Epub Date: 2024-02-08 DOI: 10.5582/bst.2023.01319

Yanan Zhao, Rong Zhang, Xiaoying Zheng

{"title":"Socioeconomic disparities in education placement for children of primary school age with autism spectrum disorder in China.","authors":"Yanan Zhao, Rong Zhang, Xiaoying Zheng","doi":"10.5582/bst.2023.01319","DOIUrl":"10.5582/bst.2023.01319","url":null,"abstract":"Relatively little is known about education placements for children with autism spectrum disorder (ASD) in China. While disparities in ASD diagnoses and services for the population broadly are often documented, the presence and determinants of differences in the educational placement of ASD children are less studied and understood. By identifying who is likely to be in segregated settings, we can discern how to best support them and facilitate a possible transition to a less restrictive setting. This study describes four placements (regular schools, special schools, institutions, homes) and their influencing factors retrospectively in a large sample (n = 2,190) of Chinese primary school-aged children (6-12 years old). We divided ASD into severe and mild to moderate categories for analysis. Children with ASD were more likely to study in a regular school (48.60%), while 13.88% were in a special school. Children with severe ASD were placed in less regular settings than children with mild to moderate ASD. However, families with higher socioeconomic status (SES) were more likely to place their children in regular schools than lower SES families if their children experienced mild to moderate symptoms. Children with severe ASD were more likely to be placed in expensive institutions for families with higher SES than those with lower SES. SES disparities in educational placement existed and had two manifestations. It is important to characterize educational placements of students with ASD to determine the extent to which they are placed in general education settings, which are often the preferred placement.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139701745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0