Bioscience trends最新文献

{"title":"Promoting an international consensus on frailty assessment: An urgent call to address the challenges of perioperative management in an aging population.","authors":"Ying Xia, Wei Tang","doi":"10.5582/bst.2026.01020","DOIUrl":"10.5582/bst.2026.01020","url":null,"abstract":"<p><p>As populations age at an unprecedented pace globally, frailty has emerged as a critical challenge in perioperative care. While clinicians broadly acknowledge the value of frailty assessment, embedding it systematically in care pathways remains difficult to implement systematically. We compared perioperative frailty guidelines from the United Kingdom, United States, Europe, and the Asia-Pacific, finding significant inconsistencies in tool selection, risk stratification criteria, and pathway design. Strikingly, approximately 99.6% of frailty research remains confined to risk characterization, whereas only 0.4% is directed toward improving care, highlighting a substantial gap between evidence and practice. Digital technologies promise a wider uptake of frailty screening, and yet algorithmic bias threatens to under-detect frailty in underserved groups if left unchecked. We outline five policy priorities: first, an internationally coordinated consensus on core assessment standards needs to be reached; second, end-to-end pathways that span screening, graded assessment, targeted intervention, and outcome tracking need to be devised; third, digital technology needs to be accelerated along with the devising of explicit safeguards for equity; fourth, high-quality evidence needs to be generated through function-centered outcomes and cost-effectiveness analyses to demonstrate the real-world value of frailty-focused care pathways; and fifth, frailty management needs to be integrated into national chronic-disease frameworks. Closing the gap between detection and action will require global collaboration and a reframing of frailty, not as a passive label but as a call to intervene.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"135-138"},"PeriodicalIF":4.9,"publicationDate":"2026-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146099598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ATF5-GPER1 axis drives female protection in hepatocellular carcinoma through dual tumor-suppressive and immune-modulatory mechanisms.","authors":"Zhiquan Xu, Hao Wang, Qiang He, Hongshuai Cui, Zhongjun Wu, Rui Liao","doi":"10.5582/bst.2026.01026","DOIUrl":"10.5582/bst.2026.01026","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) exhibits marked sexual dimorphism, with females demonstrating superior survival, yet the underlying molecular mechanisms remain unclear. We integrated bulk transcriptomics (GSE39791, TCGA-LIHC, GSE14520) and single-cell RNA sequencing (five datasets, n = 58 patients, 238,982 cells) with machine learning (LASSO, SVM, random forest) to identify female-protective genes driving HCC disparities. Activating transcription factor 5 (ATF5) emerged as a female-protective gene with higher expression in females versus males across cohorts. Single-cell analyses revealed ATF5 defines a female-enriched, low-grade malignant subcluster with elevated apoptotic programs and reduced proliferative signaling, and pseudotime analysis showed coordinated ATF5-GPER1 downregulation during malignant progression (Spearman ρ = -0.52 and -0.48; both p < 0.001). In the immune compartment, ATF5 marked a female-enriched IFN-γ⁺ macrophage state with enhanced immunostimulatory programs and preferential CXCL9/10-CXCR3-mediated communication with CD8/NK cells. Mechanistically, ATF5 transcriptionally activates G protein-coupled estrogen receptor 1 (GPER1), forming an estrogen-responsive regulatory module that functionally suppresses proliferation, induces apoptosis (HepG2: 26.45% vs. 11.88%, p < 0.0001), and inhibits migration in a GPER1-dependent manner as demonstrated by rescue experiments. Tissue microarray validation (n = 167) confirmed high ATF5 expression predicts improved recurrence-free survival specifically in female patients (HR = 0.34, p = 0.040) but not males (p = 0.080). The ATF5-GPER1 axis represents a female-protective circuit operating through tumor-intrinsic suppression and immune remodeling, offering mechanistic insight into HCC sexual dimorphism and identifying ATF5 as a sex-specific prognostic biomarker with potential therapeutic implications.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"192-204"},"PeriodicalIF":4.9,"publicationDate":"2026-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147479728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative safety and efficacy of BIC/FTC/TAF versus DTG+3TC in antiretroviral treatment-naive patients with HIV as first-line regimens: A real-world cohort study.","authors":"Liqin Sun, Yuxin Jiang, Stephane Isnard, Jingyi Chen, Yanjun Li, Hui Wang, Fang Zhao, Man Rao, Xinyun Jia, Jinping Huang, Jinwei Wu, Yinsong Luo, Dian Zhao, Chenye Liu, Xiaorui Li, Jean-Pierre Routy, Jiaye Liu, Yun He, Ping Cen, Hongzhou Lu","doi":"10.5582/bst.2025.01335","DOIUrl":"10.5582/bst.2025.01335","url":null,"abstract":"<p><p>While bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) and dolutegravir plus lamivudine (DTG+3TC) are first-line regimens for treatment-naive people with HIV (PWH), long-term real-world head-to-head comparisons of their metabolic and renal outcomes remain limited. We conducted a retrospective cohort study of ART-naive PWH initiating these regimens in China, utilizing 1:2 propensity score matching (PSM) to balance baseline covariates for 1,445 participants (901 BIC/FTC/TAF; 544 DTG+3TC). Over a 24-month follow-up, the study demonstrated comparable virologic suppression (99.7% vs. 100.0%; p = 0.623), weight changes, and cumulative incidence of metabolic abnormalities between the two groups. Conversely, although the crude 24-month incidence of eGFR decline was higher with DTG+3TC (54.8% vs. 40.7%; p = 0.039), adjusted Cox models revealed that the regimen was not independently associated with this decline (HR 1.20; 95% CI 0.97-1.48; p = 0.18).These findings indicate that both regimens offer comparable long-term virologic efficacy and metabolic safety profiles, supporting their routine clinical utility while highlighting the need for cautious interpretation of renal markers during integrase inhibitor-based therapy.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"205-216"},"PeriodicalIF":4.9,"publicationDate":"2026-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biallelic inactivation of EXT1 in patient-derived iPSCs confirms the \"Two-hit\" hypothesis in hereditary multiple osteochondromas.","authors":"Yali Yang, Zhenzhong Han, Guowei Li, Zihan Li, Chonghao Shao, Wentao Li, Jing Wang, Jing Luan, Yazhou Cui, Jinxiang Han","doi":"10.5582/bst.2026.01046","DOIUrl":"10.5582/bst.2026.01046","url":null,"abstract":"<p><p>Hereditary Multiple Osteochondromas (HMO) is a rare autosomal dominant skeletal disorder caused by heterozygous loss-of-function mutations in EXT1 or EXT2, which encode glycosyltransferases essential for heparan sulfate (HS) biosynthesis. Whether haploinsufficiency alone suffices or biallelic inactivation is required for osteochondroma formation remains a central unresolved question. In this study, we employed CRISPR/Cas9 combined with PiggyBac transposon technology to introduce a second pathogenic mutation (c.1883+1G>T) into patient-derived induced pluripotent stem cells (iPSCs) carrying a heterozygous EXT1 c.1126C>T mutation. This approach enabled the generation of isogenic iPSC lines: wild-type (WT), single-mutant (SM), and double-mutant (DM). These iPSCs were differentiated through induced mesenchymal stem cells (iMSCs) into chondrocytes. Biallelic EXT1 mutation in DM cells led to significant upregulation of SOX9, COL2A1, and ACAN, elevated glycosaminoglycan (GAG) levels, and markedly reduced HS, whereas SM cells remained indistinguishable from WT. Three-dimensional (3D) chondrogenic organoid cultures revealed that DM organoids were enlarged and structurally disorganized, partially recapitulating key histopathological features of osteochondromas. Transcriptomic analysis identified the Wnt signaling pathway as the most significantly enriched pathway among differentially expressed genes following EXT1 loss. Collectively, these findings provide direct human cellular evidence that complete EXT1 inactivation-not haploinsufficiency-drives aberrant chondrogenesis, likely through impaired sequestration of morphogen ligands, thereby supporting the Two-hit pathogenic model.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"245-253"},"PeriodicalIF":4.9,"publicationDate":"2026-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation and current status of frailty assessment in Japanese hospitals: Processes, epidemiology, and future directions.","authors":"Yi Deng, Kenji Karako, Katsuya Yamauchi, Peipei Song","doi":"10.5582/bst.2025.01392","DOIUrl":"10.5582/bst.2025.01392","url":null,"abstract":"<p><p>Frailty has become a pressing health concern in Japan as it has entered a super-aged society. Early identification of frailty is essential to preventing disability, hospitalization, and dependency on long-term care, and yet the implementation of standardized screening across clinical settings remains inconsistent. This review synthesizes current evidence on frailty assessment practices in Japan, highlights key challenges in routine implementation, and examines the potential of emerging digital tools. The feasibility of recent digital innovations - including artificial intelligence analysis of home electricity data, wearable-based mobility monitoring, and EMR-integrated frailty indices - has been demonstrated in pilot settings, though evidence of their large-scale clinical effectiveness remains limited. International comparisons have revealed that countries and regions such as the United Kingdom, Canada, Australia, and Singapore are increasingly implementing electronic frailty indices with policy-level support, offering valuable insights for Japan. Overall, although Japan has made significant progress in recognizing the importance of frailty assessment, substantial gaps remain in standardization, system integration, and clinical implementation. Strengthening national policy frameworks, enhancing workforce training, and accelerating a digital transformation may enable the development of a more comprehensive and scalable frailty-screening system to support healthy aging.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"139-148"},"PeriodicalIF":4.9,"publicationDate":"2026-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146099668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International landscape of guidelines for perioperative frailty assessment and barriers to clinical translation.","authors":"Ya-Nan Ma, Kenji Karako, Ying Xia, Peipei Song, Xiqi Hu","doi":"10.5582/bst.2025.01389","DOIUrl":"10.5582/bst.2025.01389","url":null,"abstract":"<p><p>Frailty significantly influences perioperative outcomes and healthcare resource utilization among older adults. Although the importance of intervention has been recognized, guidelines vary significantly across regions. This review synthesizes geriatric, perioperative, and specialty guidelines from the UK, the US, Europe, and the Asia-Pacific region. We found that, although they widely share core principles such as the use of validated tools and comprehensive geriatric assessment (CGA), guidance specific to the perioperative setting remains limited. Existing recommendations are often restricted to the preoperative phase and lack standardization of risk thresholds. However, high-quality evidence on the clinical and economic impact of frailty-based pathway redesigns is limited. Future research should focus on multicenter pragmatic trials that evaluate integrated care pathways extending from preoperative optimization through postoperative care. In parallel, further development of automated screening using electronic health records and electronic frailty indices is warranted. Such initiatives will require careful evaluation of feasibility and equity to support successful implementation in routine clinical practice. We recommend that clinicians routinely incorporate validated frailty screening into preoperative evaluation for all patients age 65 and older and that healthcare systems prioritize the development of an interoperable data infrastructure to enable the seamless transfer of community-derived frailty information into surgical decision-making workflows.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"149-159"},"PeriodicalIF":5.0,"publicationDate":"2026-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146099627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on precision treatment of pancreatic cancer targeted by antibody-drug conjugates.","authors":"Xinyue Liu, Weishuai Liu, Chao Wu, Yudong Yuan, Antao Chang, Jihui Hao","doi":"10.5582/bst.2025.01271","DOIUrl":"10.5582/bst.2025.01271","url":null,"abstract":"<p><p>Pancreatic cancer, and especially pancreatic ductal adenocarcinoma (PDAC), is extremely difficult to treat due to early asymptomatic stage, molecular heterogeneity, and resistance to conventional treatments, with a 5-year survival rate of less than 10%. Antibody-drug conjugates (ADCs), as an emerging precision therapy, show the potential to treat PDAC through the synergy of antibody targeting and cytotoxic drugs. Multiple targets (such as uPAR, Mesothelin, CLDN18.2, and TROP2) are highly expressed in PDAC, which has become the key direction of ADC development. However, the matrix barrier restricts drug delivery, heterogeneous expression leads to efficacy differentiation, and drug resistance mechanisms further limit the role of ADCs. To overcome these challenges, researchers are exploring high-stability single domain antibodies, more potent payloads and linkers, bystander effect mechanisms, and combined treatment strategies with immune, autophagy, DNA damage repair, and other pathways. Bispecific ADC, conditionally activated ADC, and penetration enhancement design have also been used to improve efficacy. On the whole, ADCs offer hope for the treatment of PDAC. Future research and development should focus on improving delivery efficiency, alleviating drug resistance, and individualized design.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"45-47"},"PeriodicalIF":5.0,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145556204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dual role of TRPA1 in dextran sulfate sodium (DSS)-induced murine colitis: Suppression alleviates acute inflammation but exacerbates subacute disease.","authors":"Fangzhou Dou, Jing Li, Daoran Lu, Yueyi Sun, Shasha Hu, Jianjun Gao","doi":"10.5582/bst.2025.01302","DOIUrl":"10.5582/bst.2025.01302","url":null,"abstract":"<p><p>Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited treatment options. Transient receptor potential ankyrin 1 (TRPA1) has been implicated in inflammation and pain, but its role in UC remains a subject of debate. The current study investigated the effects of TRPA1 inhibition in both acute and subacute murine models of dextran sulfate sodium (DSS)-induced colitis. Genetic knockout of Trpa1 or pharmacological inhibition with A967079 significantly ameliorated inflammation in the acute model, reducing the disease activity index (DAI), colon shortening, histopathological damage, and TNF-α secretion from macrophages. In contrast, TRPA1 suppression exacerbated subacute colitis and worsened weight loss, DAI, colon shortening, and histopathology. Mechanistically, Trpa1 deletion promoted CD4+ T cell polarization toward the Th1 subtype in subacute colitis, increasing IFN-γ levels. These findings reveal a dual role for TRPA1 in colonic inflammation: it mediates pro-inflammatory effects primarily via innate immune cells in the acute phase but has anti-inflammatory effects by modulating adaptive immunity in the subacute phase. These findings provide new insights into the context-dependent roles of TRPA1 and suggest that TRPA1 may represent a context-specific and stage-dependent therapeutic target in UC.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"91-104"},"PeriodicalIF":4.9,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146046099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting non-alcoholic fatty liver disease (NAFLD) using machine learning algorithms: Evidence from a large-scale community cohort in Taiwan.","authors":"Tzu-Chun Lin, Yu-Ju Wei, Po-Cheng Liang, Pei-Chien Tsai, Yi-Hung Lin, Meng-Hsuan Hsieh, Tyng-Yuan Jang, Chih-Wen Wang, Ming-Yen Hsieh, Zu-Yau Lin, Ming-Lun Yeh, Jee-Fu Huang, Chung-Feng Huang, Wan-Long Chuang, Ming-Lung Yu, Chia-Yen Dai, Hon-Yi Shi","doi":"10.5582/bst.2025.01323","DOIUrl":"10.5582/bst.2025.01323","url":null,"abstract":"<p><p>Closely associated with metabolic disorders, non-alcoholic fatty liver disease (NAFLD) substantially increases the risk of hepatocellular carcinoma. This study aimed to apply machine learning (ML) algorithms to a community-based cohort in southern Taiwan to identify key risk factors for NAFLD and to develop predictive models with clinical applicability. Data were derived from community health examinations, and eighteen clinical and demographic features were analyzed. Five ML algorithms were evaluated: logistic regression (LR), random forest (RF), K-nearest neighbors (KNN), adaptive boosting (AdaBoost), and extreme gradient boosting (XGBoost). Model performance was assessed using accuracy, precision, recall, F1 score, and area under the receiver operating characteristic curve (AUROC). A total of 7,510 participants were included (38.8% male; mean age 50.9 ± 15.0 years). The dataset was randomly divided into training (80%) and testing (20%) subsets, with no significant differences observed between groups in most independent variables. The Synthetic Minority Over-sampling Technique (SMOTE) was employed to balance NAFLD and non-NAFLD groups in the training dataset. Among all models, XGBoost achieved the highest performance, with an accuracy of 83.48%, precision of 84.31%, recall of 81.21%, F1 score of 82.72%, and AUROC of 92.85%. Feature importance analysis identified low-density lipoprotein cholesterol (LDL-C), body mass index (BMI), waist circumference, fasting plasma glucose (FPG), and triglycerides (TG) as the most influential predictors of NAFLD. ML algorithms, particularly XGBoost, demonstrated high accuracy in predicting NAFLD and effectively identified key clinical predictors. These findings may enhance early diagnosis and facilitate the development of targeted intervention strategies in the management of NAFLD.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"80-90"},"PeriodicalIF":4.9,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated alpha-fetoprotein affects the long-term prognosis after hepatectomy in patients with hepatitis B-related intrahepatic cholangiocarcinoma.","authors":"Yizhe Dai, Shilei Bai, Pinghua Yang, Huifeng Wang, Xiaoying Li, Feng Shen, Kui Wang","doi":"10.5582/bst.2025.01327","DOIUrl":"10.5582/bst.2025.01327","url":null,"abstract":"<p><p>This study investigates the prognostic significance of alpha-fetoprotein (AFP) in hepatitis B virus-related intrahepatic cholangiocarcinoma (HBV-ICC), given that AFP - though commonly used for hepatocellular carcinoma - is sometimes elevated in HBV-ICC, yet its clinical relevance remains unclear. The research retrospectively analyzed 839 HBV-ICC patients who underwent curative hepatectomy, categorizing them into AFP-positive (≥ 20 ng/mL) and AFP-negative groups. Using propensity score matching and inverse probability of treatment weighting to reduce bias, the study compared overall survival (OS) and time to recurrence (TTR). Results showed that AFP-positive patients had poorer liver function and more aggressive tumor characteristics, including higher rates of cirrhosis, microvascular invasion, and satellite nodules. Across both unadjusted and adjusted cohorts, elevated AFP was significantly associated with worse OS and earlier recurrence. Multivariate Cox analysis identified AFP as an independent predictor of poor prognosis. While CA19-9 alone demonstrated limited predictive value, its combination with AFP improved prognostic accuracy. The study concludes that elevated serum AFP independently predicts adverse survival and recurrence outcomes in HBV-ICC patients after curative resection, and combining AFP with CA19-9 enhances prognostic stratification, supporting AFP as a practical biomarker for postoperative risk assessment.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"105-121"},"PeriodicalIF":4.9,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}