Bioscience trends最新文献

{"title":"The inflammation-aging axis: Shared and distinct mechanisms in physiological gut aging and IBD-associated accelerated gut aging.","authors":"Lichao Yang, Zhixian Jiang, Qi Sun, Kenji Karako, Lianwen Yuan, Peipei Song","doi":"10.5582/bst.2025.01279","DOIUrl":"10.5582/bst.2025.01279","url":null,"abstract":"<p><p>Inflammatory bowel disease (IBD) and physiological gut aging present with overlapping clinical features, including impaired barrier functioning, decreased nutrient absorption, and intestinal frailty. Emerging evidence indicates that even young IBD patients can exhibit gut phenotypes akin to those seen with aging. However, the two processes differ substantially in their underlying mechanisms. Gut aging is characterized by low-grade, chronic inflammation and gradual cellular senescence, whereas IBD involves persistent immune activation, cyclical tissue damage, and accelerated degenerative changes. This review systematically contrasts physiological gut aging and IBD-associated accelerated gut aging across several dimensions: cellular senescence and programmed cell death, immune cell remodeling, alterations in gut microbiota, changes in mesenteric adipose tissue, and the evolving role of the appendix. By integrating current advances in basic and translational research, this article highlights both the shared and distinct pathways driving gut dysfunction in aging and IBD, and underscores the importance of early recognition and targeted intervention for premature gut aging in clinical practice.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"27-44"},"PeriodicalIF":5.0,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145556209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implications of mitochondrial function in embryonic development.","authors":"Jing Wang, Jing Zhou, Yanying Wang, Yun Li, Ling Wang, Lisha Li","doi":"10.5582/bst.2026.01002","DOIUrl":"10.5582/bst.2026.01002","url":null,"abstract":"<p><p>Mitochondria are organelles that play a crucial role in various physiological processes. They are particularly important during embryonic development, as their proper function is required for essential processes such as fertilization, implantation, and embryonic growth. In addition to their well-known role in adenosine triphosphate (ATP) synthesis and energy production, mitochondria serve multiple other functions during embryonic development. These include the synthesis of important metabolites, involvement in cell signaling pathways, regulation of reactive oxygen species, and facilitation of interactions between organelles. The mitochondrial genome, known as mitochondrial DNA (mtDNA), also plays a unique role in embryonic development. Dysfunction in mitochondria can lead to failures in fertilization, suboptimal embryo development, post-implantation failures, and mitochondrial-related diseases in adults. Advances in sequencing technology and experimental techniques have greatly improved our understanding of mitochondrial function. This paper reviews the roles of mitochondrial functions in embryonic development and the influence of mitochondrial technologies and it highlights the potential impact of understanding mitochondria's unique genetic and functional characteristics on embryonic development and offspring health.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"14-26"},"PeriodicalIF":4.9,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term effects of multidisciplinary team recommendations on adult patients with acute myeloid leukemia.","authors":"Jingtao Huang, Yiwen Wu, Yunxiang Zhang, Chuanhe Jiang, Min Wu, Zengkai Pan, Qiusheng Chen, Huijin Zhao, Yu Zheng, Yang Shen, Yang He, Jiong Hu, Junmin Li, Xiaoxia Hu","doi":"10.5582/bst.2025.01354","DOIUrl":"10.5582/bst.2025.01354","url":null,"abstract":"<p><p>Optimal post-remission therapy is crucial for long-term survival in patients with acute myeloid leukemia (AML). Multidisciplinary team (MDT) conferences address this challenge by providing comprehensive, patient-centered consultations that support individualized treatment decision-making. We evaluated the effectiveness of MDT conferences in guiding post-remission treatment decisions in adults with de novo AML. We enrolled 653 adult patients with de novo AML who were treated at our center between January 2017 and December 2022. Of the 591 eligible patients (90.5%), 501 (84.8%) attended a scheduled MDT evaluation. Allogeneic hematopoietic cell transplantation (allo-HCT) was recommended for 315 patients (62.9%), of whom 251 (79.7%) subsequently underwent transplantation. Survival analyses showed that MDT attendees had superior 3-year overall survival (68.9% vs. 53.5%, p < 0.0001) and a lower 3-year cumulative incidence of relapse (30.7% vs. 44.9%; p < 0.0001) compared with patients who did not attend MDT conferences. Patients most likely to benefit from allo-HCT following MDT recommendations included those with intermediate- or adverse-risk disease according to the European LeukemiaNet 2017 classification, and those with favorable-risk disease who showed a suboptimal response to induction therapy. The main barriers to allo-HCT were persistent or relapsed disease and patient preference. Overall, MDT conferences effectively identified patients who were most likely to benefit from allo-HCT and were associated with higher transplantation rates within a modern healthcare system.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"122-134"},"PeriodicalIF":4.9,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoughts on dietary interventions for metabolic syndrome (MetS) in an era of metabolic heterogeneity.","authors":"Wei Tang","doi":"10.5582/bst.2026.01055","DOIUrl":"10.5582/bst.2026.01055","url":null,"abstract":"<p><p>Metabolic syndrome (MetS) has long been used as a pragmatic tool for population-level cardiometabolic risk stratification, rather than as a mechanistically defined disease entity. However, mounting evidence suggests the existence of marked biological heterogeneity among individuals meeting identical MetS criteria, encompassing diverse metabolic phenotypes, disease trajectories, and responses to interventions. Such heterogeneity helps explain the limited and inconsistent effectiveness of uniform dietary strategies. In parallel, dietary research has shifted from a nutrient-centric approach to a food-based dietary pattern, emphasizing higher intakes of whole foods and reduced consumption of ultra-processed foods. In the context of metabolic heterogeneity, these shared food-level characteristics may confer relatively consistent metabolic benefits across diverse phenotypes. Future research may shift from uniform dietary recommendations to stratified strategies, grounded in dietary principles and informed by mechanistic insights, to better address metabolic heterogeneity.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"1-4"},"PeriodicalIF":4.9,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147302076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacteriophage-derived depolymerases as antimicrobial synergists: A strategy to overcome resistance.","authors":"Shuhong Han, David H Yang, Jiayin Shen, Hongzhou Lu","doi":"10.5582/bst.2026.01003","DOIUrl":"10.5582/bst.2026.01003","url":null,"abstract":"<p><p>Upon infection, bacteria form polysaccharides barriers, such as capsular polysaccharide (CPS), exopolysaccharide (EPS) and lipopolysaccharide (LPS). The barrier hinders antibiotic penetration and host immune clearance, exacerbating antimicrobial resistance crisis. Bacteriophages (phages), natural viruses that can specifically infect and kill bacteria, have evolved depolymerase to degrade the polysaccharides. This review evaluates the primary therapeutic value of depolymerases as synergists to existing therapies, systematically detailing their potential to enhance antibiotic efficacy, improve phage therapy, and augment host immunity. We further integrate an evolutionary perspective to analyze likely adaptive responses and potential strategies to eradicate resistance. Finally, the discussion addresses formulation challenges and future prospects for the clinical translation of depolymerase-based synergistic therapies.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"5-13"},"PeriodicalIF":4.9,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary patterns and metabolic syndrome in a population living at a high altitude and consuming a halal diet: A cross-sectional study combining Dietary Approaches to Stop Hypertension (DASH) principles and locally derived patterns.","authors":"Yuanzheng Liu, Tiemei Li, Wen Peng, Peipei Song, Yanming Ren","doi":"10.5582/bst.2026.01030","DOIUrl":"10.5582/bst.2026.01030","url":null,"abstract":"<p><p>Metabolic syndrome (MetS), characterized by the clustering of metabolic risk factors, substantially increases the risk of cardiovascular disease and type 2 diabetes. Although dietary patterns (DPs) are known to influence MetS, evidence remains limited regarding the applicability of established dietary principles in populations living at a high altitude in an environment with a halal diet. This study examined the associations between both a priori and locally derived DPs and MetS and its components, with particular emphasis on low high-density lipoprotein cholesterol (HDL-C). A cross-sectional analysis was performed among 1,133 adults ages 18-80 using data from an ongoing pilot cohort study (2024-2025). DPs were identified using a modified Dietary Approaches to Stop Hypertension (DASH) score and factor analysis. Associations with MetS and its components were assessed using inverse probability of exposure-weighted logistic regression. Subgroup and interaction analyses evaluated effect modification, and mediation analysis examined the mediating role of being overweight. The prevalence of MetS was 54.81%. Three major DPs were identified: the Sugary Drinks and Fast-Food Pattern, the Halal Protein-Rich Pattern, and the Traditional Grain and Tonic Pattern. The DASH score was moderately correlated with the Halal Protein-Rich Pattern (Spearman's r = 0.37). Participants in the highest tertile of the Halal Protein-Rich Pattern had a significantly lower risk of MetS compared to those in the lowest tertile (OR = 0.64, 95% CI: 0.45-0.92; p for trend < 0.05), as well as a 35% lower risk of low HDL-C. In contrast, higher adherence to the Sugary Drinks and Fast-Food Pattern was associated with an increased risk of low HDL-C. Similar protective associations were observed for higher DASH scores. Subgroup analyses showed that the Halal Protein-Rich Pattern was inversely associated with MetS among overweight participants (OR = 0.80, 95% CI: 0.66-0.96). Mediation analysis indicated that being overweight mediated 19.84% of the association between the Halal Protein-Rich Pattern and MetS. In conclusion, in a high-altitude environment with a halal diet, both DASH and a culturally adapted Halal Protein-Rich Pattern were inversely associated with MetS and low HDL-C in particular. DASH offers an evidence-based guideline, while the Halal Protein-Rich Pattern reflects a culturally appropriate and locally practical diet. Longitudinal studies are warranted to confirm these findings.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"58-79"},"PeriodicalIF":4.9,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147302010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are artificial retinas merely an approach to recover sight, or are they a tool of augmented reality beyond natural eyes in blind people?","authors":"Zijia Zhao, Tetsuya Asakawa","doi":"10.5582/bst.2025.01341","DOIUrl":"10.5582/bst.2025.01341","url":null,"abstract":"<p><p>Implantable artificial retinas have been a considerable technology to help blind people recover their sight. This topic has attracted increasing attention from both patients and clinicians because of the refractory nature of degenerative retinal diseases. A point worth noting is that artificial retinas are conventionally considered to be a tool to help blind patients recover their sight. With the development of materials and sensors, however, such devices might have characteristics of augmented reality that are beyond the capabilities of the natural eye. This study briefly summarizes the current clinical status of implantable artificial retinas, it explores emerging technologies that aim to augment vision, and it discusses the challenges that must be overcome before these devices can be further used clinically. Indeed, the implantation of such advanced retinal prostheses with augmented reality characteristics may bring about new ethical and legal risks that warrant further consideration.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"601-606"},"PeriodicalIF":5.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145647222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hearing impairment in Parkinson's disease models: Possible relation with changes in cochlear efferent fibers.","authors":"Hao Zhao, Shijun Peng, Rui Zhao, Tongxiang Diao, Yixin Zhao, Xin Ma, Hongwei Zheng, Yixu Wang, Lisheng Yu","doi":"10.5582/bst.2025.01316","DOIUrl":"10.5582/bst.2025.01316","url":null,"abstract":"<p><p>Hearing impairments, as a prevalent and debilitating non-motor symptom of Parkinson's disease (PD), remain unclear in mechanisms. In this work, we established PD mouse and rat models by using 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA), respectively, and investigated their hearing functions and potential mechanisms through auditory brainstem response (ABR), distortion product otoacoustic Emissions (DPOAE), noise exposure, immunofluorescence labeling, volumetric measurement, and colocalization analysis. In MPTP-induced PD mice, we observed significant cholinergic fibers decompensation, heterogeneous dopaminergic fibers damage of cochlear efferent fibers, and adrenergic sympathetic fibers marked loss in the osseous spiral lamina (OSL), corresponding to insignificant cochlear hair cells, ribbon synapse alteration, and auditory sensitivity injury. While in 6-OHDA-induced PD rats, asymmetric alterations in cochlear cholinergic, dopaminergic fibers were found, accompanied by inconsistent adrenergic changes in the OSL, which matched unilateral hair cells, ribbon synapse damage, and hearing loss. Overall, findings from this work indicate that pathological alterations in the cochlea of PD mice and rats, particularly in efferent fibers, may be closely relevant to peripheral hearing alterations.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"699-715"},"PeriodicalIF":5.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145803094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transformation of healthcare models and creation of integrated care systems in an aging society: A comparative perspective of the Netherlands, Japan, and China.","authors":"Ren Chen, Wei Tang","doi":"10.5582/bst.2025.01317","DOIUrl":"10.5582/bst.2025.01317","url":null,"abstract":"<p><p>Faced with the global challenges of population aging and a surge in dementia cases, healthcare models worldwide are undergoing profound transformation. The Netherlands' \"dementia villages\" concept simulates living environments, with their antipsychotic drug usage rate (11%) being significantly lower than in traditional facilities (52%). Japan has established over 12,000 \"small-scale multi-functional\" care facilities, striving to achieve \"life in the community.\" Meanwhile, China is promoting community-embedded elderly care models, exemplified by Shanghai's plan to increase the number of daycare centers from 720 in 2019 to 919 by 2024, establishing a \"15-minute elderly care circle.\" This commentary compares the Netherlands, Japan, and China across four dimensions: aging trends, innovative care models, the development of multifunctional healthcare systems, and end-of-life care philosophies. It assesses current policy developments and practical challenges, proposing that future sustainable care systems should integrate healthcare with community resources, institutional frameworks with ethical considerations, technological advancements with humanistic values, and education on death with the preservation of life with dignity.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"594-600"},"PeriodicalIF":5.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145450654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Yiqi Bushen Shugan Huoxue Decoction on impaired endometrial receptivity associated with ovarian stimulation: A clinical trial, modular pharmacology, molecular docking, and experiment-based study.","authors":"Xinyao Pan, Qing Qi, Jing Wang, Jing Zhou, Hongmei Sun, Lisha Li, Ling Wang","doi":"10.5582/bst.2025.01325","DOIUrl":"10.5582/bst.2025.01325","url":null,"abstract":"<p><p>Endometrial receptivity plays a critical role in pregnancy, while controlled ovarian hyperstimulation (COH) - widely used for infertile patients - could impair endometrial receptivity and subsequent pregnancy outcomes. This study aims to explore the effect of Yiqi Bushen Shugan Huoxue Decoction (YBSHD) on impaired endometrial receptivity in patients with unexplained infertility (UI) undergoing COH and to determine the mechanism for it through modular pharmacology, molecular docking, and a murine model. First, we retrospectively studied 422 patients with UI who underwent COH to get pregnant. Results indicated that the live birth rate significantly increased in the YBSHD group. Second, a systematic network pharmacology analysis was performed to screen the ingredients and possible targets of YBSHD. The main targets concerning YBSHD and endometrial receptivity involved pathways including hormone regulation, inflammatory responses, and apoptosis. The active components of quercetin and kaempferol from YBSHD exhibited a strong binding affinity to key molecules, including BCL2, ESR1, IL6, IL1B, and TNF. Third, YBSHD improved endometrial receptivity in a murine COH model. Compared to the COH group, the number of embryo implantations and endometrial pinopodes significantly increased in the YBSHD group, indicating improved endometrial receptivity. YBSHD improved the local immune microenvironment in COH mice by regulating excessive hormone secretion, gene expression of inflammatory factors, and proportions of neutrophils and macrophages. Moreover, YBSHD inhibited apoptosis in the ovaries and uteruses of COH mice. In summary, YBSHD could increase the live birth rate in patients with UI, mainly because it can inhibit inflammation and cell apoptosis, thereby improving endometrial receptivity.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"684-698"},"PeriodicalIF":5.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145773383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}