Bioscience trends最新文献_第10页

The effect of the female genital tract and gut microbiome on reproductive dysfunction. 女性生殖道和肠道微生物群对生殖功能障碍的影响。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-01-30 Epub Date: 2023-12-17 DOI: 10.5582/bst.2023.01133

Wenli Cao, Xiayan Fu, Jing Zhou, Qing Qi, Feijun Ye, Lisha Li, Ling Wang

{"title":"The effect of the female genital tract and gut microbiome on reproductive dysfunction.","authors":"Wenli Cao, Xiayan Fu, Jing Zhou, Qing Qi, Feijun Ye, Lisha Li, Ling Wang","doi":"10.5582/bst.2023.01133","DOIUrl":"10.5582/bst.2023.01133","url":null,"abstract":"Microorganisms are ubiquitous in the human body; they are present in various areas including the gut, mouth, skin, respiratory tract, and reproductive tract. The interaction between the microbiome and reproductive health has become an increasingly compelling area of study. Disruption of the female genital tract microbiome can significantly impact the metabolism of amino acids, carbohydrates, and lipids, increasing susceptibility to reproductive tract diseases such as vaginitis, chronic endometritis, endometrial polyps, endometriosis, and polycystic ovary syndrome. The gut microbiome, considered an endocrine organ, plays a crucial role in the reproductive endocrine system by interacting with hormones like estrogen and androgens. Imbalances in the gut microbiome composition can lead to various diseases and conditions, including polycystic ovary syndrome, endometriosis, and cancer, although research on their mechanisms remains limited. This review highlights the latest advancements in understanding the female genital tract and gut microbiomes in gynecological diseases. It also explores the potential of microbial communities in the treatment of reproductive diseases. Future research should focus on identifying the molecular mechanisms underlying the association between the microbiome and reproductive diseases to develop new and effective strategies for disease prevention, diagnosis, and treatment related to female reproductive organs.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"458-474"},"PeriodicalIF":5.5,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conversion therapy for initially unresectable hepatocellular carcinoma: Current status and prospects. 最初无法切除的肝细胞癌的转化疗法：现状与前景。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-01-30 Epub Date: 2023-12-23 DOI: 10.5582/bst.2023.01322

Ya-Nan Ma, Xuemei Jiang, Hui Liu, Peipei Song, Wei Tang

{"title":"Conversion therapy for initially unresectable hepatocellular carcinoma: Current status and prospects.","authors":"Ya-Nan Ma, Xuemei Jiang, Hui Liu, Peipei Song, Wei Tang","doi":"10.5582/bst.2023.01322","DOIUrl":"10.5582/bst.2023.01322","url":null,"abstract":"Research has shown that locoregional and/or systemic treatments can reduce the tumor stage, enabling radical surgical resection in patients with initially unresectable hepatocellular carcinoma. This is referred to as conversion therapy. Patients who undergo conversion therapy followed by curative surgery experience a significant survival benefit compared to those who receive chemotherapy alone, those who are successfully downstaged with conversion therapy but not treated with surgery, or those who are treated with upfront surgery. Several treatments have been studied as conversion therapy. However, the success rate of conversion varies greatly, ranging from 0.8% to 60%. Combined locoregional plus systemic conversion therapy has demonstrated significant clinical advantages, with a conversion rate of up to 60%, an objective remission rate of 96% for patients, and a disease control rate of up to 100%. However, patients who underwent conversion therapy experienced significantly more complications than those who underwent direct LR without conversion therapy. Conversion therapy can cause hepatotoxicity, bone marrow suppression, local adhesions, increased fragility of blood vessels and liver tissues, and hepatic edema, which can increase the difficulty of surgery. In addition, criteria need to be established to evaluate the efficacy of conversion therapy and subsequent treatment. Further clinical evidence in this area is urgently needed.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"415-426"},"PeriodicalIF":5.5,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in the treatment of advanced pancreatic cancer. 晚期胰腺癌的治疗趋势。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2024-01-01 DOI: 10.5582/bst.2024.01156

Hirokazu Momose, Shohei Kudo, Tomoyuki Yoshida, Nobuhiro Hasui, Ryota Matsuki, Masaharu Kogure, Yoshihiro Sakamoto

引用次数: 0

Expert consensus on sequential surgery after immune-targeted conversion therapy for advanced hepatocellular carcinoma in China. 中国晚期肝癌免疫靶向转化治疗后序贯手术的专家共识

IF 5.7 4区生物学

Bioscience trends Pub Date : 2024-01-01 DOI: 10.5582/bst.2024.01423

Peipei Song, Wei Tang, Norihiro Kokudo

引用次数: 0

Addressing healthy aging in China: Practices and prospects. 中国应对健康老龄化：实践与展望。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2024-01-01 DOI: 10.5582/bst.2024.01180

Haiyin Wang, Dan Qin, Liang Fang, Hui Liu, Peipei Song

{"title":"Addressing healthy aging in China: Practices and prospects.","authors":"Haiyin Wang, Dan Qin, Liang Fang, Hui Liu, Peipei Song","doi":"10.5582/bst.2024.01180","DOIUrl":"https://doi.org/10.5582/bst.2024.01180","url":null,"abstract":"One important challenge for global development is aging. China is one of the world's countries with the highest elderly population and the most rapid aging; in 2022, the percentage of the population over 65 was 14.9%; by 2050, it is expected to rise to 26.1%. China's health security, elderly care, and healthcare services are facing serious challenges as a result of this aging trend. With 80% of provinces including medical and elderly care in national basic public health care programs, China has adopted a proactive national plan to combat population aging. Moreover, geriatric departments have been established at 69.3% of public general hospitals at secondary and higher tiers, 48% of provinces have devises preventive interventions for disability and dementia in the elderly, 48 percent of provinces are serving as test regions for medical care related to rehabilitation, and 49 cities are involved in long-term care insurance (LTCI) trials that encompass 170 million people. There are 4,259 medical and health care facilities that provide hospice care services, 152 hospice care pilot regions, and 87,000 pairs of contracts between medical and health care facilities and elderly care providers. These developments provide a strong basis, but there are still major obstacles to overcome. The Chinese Government is urged to adopt early preventive measures, offer more ongoing, practical, and cost-effective diagnostic and treatment services, allocate resources equitably, and use intelligent technologies to enhance elderly care. The ultimate goals are to lessen the financial burden, enhance the health of the elderly, and offer a vital global resource.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":"18 3","pages":"212-218"},"PeriodicalIF":5.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141578937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sarcopenia and risk of cardio-cerebrovascular disease: A two-sample Mendelian randomization study. Sarcopenia与心脑血管疾病风险：一项两样本孟德尔随机化研究。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2023-11-18 Epub Date: 2023-10-21 DOI: 10.5582/bst.2023.01246

Qifeng Ou, Ding Pan

{"title":"Sarcopenia and risk of cardio-cerebrovascular disease: A two-sample Mendelian randomization study.","authors":"Qifeng Ou, Ding Pan","doi":"10.5582/bst.2023.01246","DOIUrl":"10.5582/bst.2023.01246","url":null,"abstract":"Based on the association between sarcopenia and the risk of developing cardio-cerebrovascular disease (CCVD) established by a meta-analysis by Fang et al.(Biosci Trends. 2023; 17:293-301), we have used Mendelian randomization (MR) analysis to test the authenticity and accuracy of such an association. In this MR study, appendicular lean mass, handgrip strength, and walking pace were used as sarcopenia-related traits, with cardiovascular diseases and stroke set as outcomes of CCVD. MR analysis was performed using inverse-variance weighting, the MR Egger, weighted median, simple mode, and weighted mode. No heterogeneity or horizontal pleiotropy in MR estimates was observed (Cochran's Q P value > 0.05, MR-PRESSO global test P value > 0.05, and MR-Egger intercept P value > 0.05). Results of that analysis proved a causal relationship between sarcopenia-related traits and cardio-cerebrovascular disease, with a causal association between appendicular lean mass and cardiovascular diseases and an inverse causal relationship between appendicular lean mass and stroke. However, such a relationship was absent in the case of handgrip strength and the risk of cardiovascular diseases as well as in the case of walking pace and lacunar/ischemic stroke. Therefore, the effect of sarcopenia on CCVD should be carefully explained.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"413-414"},"PeriodicalIF":5.5,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical indications for solid hepatic benign tumors: An updated literature review. 肝实体良性肿瘤的手术指征:最新文献综述。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2023-11-18 Epub Date: 2023-08-19 DOI: 10.5582/bst.2023.01152

Zhihong Zhang, Jun Ji, Guoteng Qiu, Ziqi Hou, Shizheng Mi, Zhaoxing Jin, Yunlong Dai, Qingyun Xie, Yong Zeng, Jiwei Huang

引用次数: 0

The function and immune role of cuproptosis associated hub gene in Barrett's esophagus and esophageal adenocarcinoma. 铜中毒相关枢纽基因在Barrett食管和食管腺癌中的功能和免疫作用。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2023-11-18 Epub Date: 2023-10-21 DOI: 10.5582/bst.2023.01164

Kailin Lin, Ke Hu, Qiwen Chen, Jiangchun Wu

{"title":"The function and immune role of cuproptosis associated hub gene in Barrett's esophagus and esophageal adenocarcinoma.","authors":"Kailin Lin, Ke Hu, Qiwen Chen, Jiangchun Wu","doi":"10.5582/bst.2023.01164","DOIUrl":"10.5582/bst.2023.01164","url":null,"abstract":"Barrett's esophagus (BE) is a precancerous lesion of esophageal adenocarcinoma (EAC), with approximately 3-5% of patients developing EAC. Cuproptosis is a kind of programmed cell death phenomenon discovered in recent years, which is related to the occurrence and development of many diseases. However, its role in BE and EAC is not fully understood. We used single sample Gene Set Enrichment Analysis (ssGSEA) for differential analysis of BE in the database, followed by enrichment analysis of Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Ontology (GO) and GSEA, Protein-Protein Interaction (PPI), Weighted Gene Co-expression Network Analysis (WGCNA), Receiver Operating Characteristic Curve (ROC) and finally Quantitative Real Time Polymerase Chain Reaction (qRT-PCR) and immunohistochemistry (IHC) of clinical tissues. Two hub genes can be obtained by intersection of the results obtained from the cuproptosis signal analysis based on BE. The ROC curves of these two genes predicted EAC, and the Area Under the Curve (AUC) values could reach 0.950 and 0.946, respectively. The mRNA and protein levels of Centrosome associated protein E (CENPE) and Shc SH2 domain binding protein 1 (SHCBP1) were significantly increased in clinical EAC tissues. When they were grouped by protein expression levels, high expression of CENPE or SHCBP1 had a poor prognosis. The CENPE and SHCBP1 associated with cuproptosis may be a factor promoting the development of BE into EAC which associated with the regulation of NK cells and T cells.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"381-392"},"PeriodicalIF":5.5,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Call for special attention to the caregiver burden of patients with drug-resistant tuberculosis in low- and middle-income countries. 呼吁特别关注中低收入国家耐药结核病患者的护理负担。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2023-11-18 Epub Date: 2023-10-14 DOI: 10.5582/bst.2023.01243

Shuqi Wu, Hailin Zhang, Yi Wang, Jin Wang, Peize Zhang, Tetsuya Asakawa, Yi Lin

引用次数: 0

Clinical characteristics of solitary intrahepatic biliary cyst. 孤立性肝内胆道囊肿的临床特点。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2023-11-18 Epub Date: 2023-08-30 DOI: 10.5582/bst.2023.01042

Zhipeng Sun, Bing Liu, Bin Shu, Xin Huang, Liang Wang, Shizhong Yang

引用次数: 0