Bioscience trends最新文献

{"title":"Neurotropin alleviates Alzheimer's disease pathology by inhibiting FUS-mediated Calhm2 transcription, blocking the Calhm2/EFhd2 interaction, to improve mitochondrial dysfunction-associated microglia polarization.","authors":"Yuanlu Huang, Fusheng Wei, Xiaoe Cheng, Yinqi Shi, Ziye Liu, Lingling Ye","doi":"10.5582/bst.2025.01220","DOIUrl":"https://doi.org/10.5582/bst.2025.01220","url":null,"abstract":"<p><p>Neurotropin, a non-protein extract widely used for the treatment of neuropathic pain, has recently been reported to protect against ischemic brain injury, enhance remyelination in demyelinating diseases, and ameliorate neuroinflammation and memory deficits. However, its role in microglial polarization and mitochondrial dysfunction in Alzheimer's disease (AD) remains poorly understood. In this study, we investigated the therapeutic potential of Neurotropin in the 5xFAD mouse model of AD. Neurotropin administration alleviated cognitive decline, reduced amyloid-β (Aβ) deposition, suppressed neuroinflammation, and preserved neuronal density. Mechanistically, Neurotropin improved mitochondrial morphology, restored ATP production, increased mitochondrial DNA copy number, and reduced oxidative stress while promoting a shift in microglial polarization from the pro-inflammatory M1 phenotype toward the anti-inflammatory M2 phenotype. Transcriptomic and molecular analyses revealed that calcium homeostasis modulator family member 2 (Calhm2) was markedly upregulated in 5xFAD mice, colocalized with microglia, and transcriptionally regulated by fused in sarcoma (FUS), while Calhm2 interacted with EF-hand domain containing protein D2 (EFhd2). Neurotropin suppressed FUS-mediated Calhm2 transcription and attenuated Calhm2-EFhd2 interaction. Importantly, overexpression of Calhm2 in both microglial cells and 5xFAD mice abolished the beneficial effects of Neurotropin, leading to exacerbated mitochondrial dysfunction, oxidative stress, and inflammatory cytokine release. Together, these findings identify Calhm2 as a critical mediator of Neurotropin's neuroprotective effects and demonstrate that Neurotropin alleviates AD pathology by suppressing FUS-dependent Calhm2 transcription and blocking the Calhm2/EFhd2 interaction. This study provides new insights into the mechanism of Neurotropin action and highlights its therapeutic potential for AD.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the pathway of a social network in promoting the individual performance of core members of social organizations caring for the elderly: A moderated mediation model of social support and self-efficacy.","authors":"Xin Zheng, Sanyuan Hao, Ziwen Xu, Jiajie Zhao, Fuqin Xu, Shuo Ding, Guoqing Liu, Shufan Yang, Benjamin Otsen, Wen Zhu, Jie Yang, Zhongliang Bai, Ren Chen","doi":"10.5582/bst.2025.01225","DOIUrl":"https://doi.org/10.5582/bst.2025.01225","url":null,"abstract":"<p><p>The high performance of core members of social organizations (SOs) caring for the elderly can enhance the quality of management and services, thereby improving the life satisfaction of older adults residing there. However, the factors influencing the performance of core members and their pathways remain unclear. This research seeks to uncover how social support mediates and self-efficacy moderates the association between a social network and individual performance of core members of SOs caring for the elderly. A cross-sectional survey was conducted from June to August 2023 in Shanghai, China, and data on participants' demographics, social network, social support, individual performance, and self-efficacy were collected. Hierarchical stepwise regression, bootstrap analysis, and simple slope method analysis were used to test potential mediating and moderating effects. After adjusting for confounders, the total effect of a social network on core members' individual performance (β = 0.078, 95% CI: 0.052-0.103) consisted of a direct effect (β = 0.059, 95% CI: 0.030-0.087) as well as an indirect effect mediated through social support (β = 0.019, 95% CI: 0.006-0.033). In addition, self-efficacy was identified as a moderating factor in the relationship between a social network and individual performance, with higher levels of self-efficacy diminishing the influence of a social network on performance outcomes. An extensive social network can enhance social support for core members of SOs caring for the elderly, thereby improving individual performance. Concurrently, targeted interventions should be developed to draw on self-efficacy to activate social network resources and to have a synergistic effect on individual performance.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical study of the caudate lobe of the liver on hepatic casts and the dawn of isolated caudate lobectomy.","authors":"Yoshihiro Sakamoto, Masaharu Kogure, Satoru Seo, Masamitsu Kumon","doi":"10.5582/bst.2025.01246","DOIUrl":"10.5582/bst.2025.01246","url":null,"abstract":"<p><p>Surgical resection of the caudate lobe of the liver remains the final hurdle for liver surgeons, not only in open hepatectomy but also in recent minimally invasive hepatectomy. In the dawn of liver surgery, Prof. Kumon made hepatic casts and showed the anatomy of the caudate lobe of the liver based on the portal segmentation in the National Cancer Center Hospital, Tokyo. Meanwhile, liver surgeons in the center successfully performed isolated caudate lobectomy of the liver for liver cancers one after another. Prof. Kumon is still dissecting hepatic casts to demonstrate the right border of the paracaval portion of the caudate lobe against segment VIII of the liver. An approach to right hemihepatectomy preserving the paracaval portion of the caudate lobe was developed thanks to the detailed anatomical knowledge of the liver based on hepatic casts.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"374-378"},"PeriodicalIF":5.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Textbook outcome and survival following laparoscopic versus open right hemihepatectomy for hepatocellular carcinoma: A propensity score-matched study.","authors":"Jun Ji, Ding Hu, Jiaao Wang, Ziqi Hou, Zhihong Zhang, Haichuan Wang, Jiwei Huang","doi":"10.5582/bst.2025.01208","DOIUrl":"10.5582/bst.2025.01208","url":null,"abstract":"<p><p>The role of laparoscopy for complex resections like right hemihepatectomy for hepatocellular carcinoma (HCC) remains contentious, and its assessment is often hampered by traditional metrics that fail to reflect the comprehensive quality of perioperative management. Therefore, this study used the textbook outcome (TO), a composite endpoint, to compare the laparoscopic (LRH) and open (ORH) approaches for HCC within a propensity score-matched (PSM) analysis. We retrospectively analyzed 435 patients who underwent curative-intent right hemihepatectomy. After 1:3 PSM, a final cohort of 121 patients who underwent LRH and 242 who underwent ORH was included for analysis. Results indicated that the rate of TO achievement was comparable between the LRH and ORH groups (62.0% vs. 65.3%, p = 0.563), with intraoperative complications (17.4%), post-hepatectomy liver failure (14.9%), and major postoperative complications (13.5%) as the primary barriers to achieving a TO. No significant differences in overall survival (OS) or disease-free survival (DFS) were observed, although the LRH group had a significantly shorter duration of hospitalization (p = 0.006). In multivariable Cox regression models, achieving a TO was confirmed as an independent protective factor for both OS (HR: 0.46, 95% CI: 0.34-0.63, p < 0.001) and DFS (HR: 0.44, 95% CI: 0.33-0.58, p < 0.001). For right hemihepatectomy, clinical practice should focus on maximizing the rate of TO achievement through systematic perioperative management, as a key strategy to improve long-term prognosis.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"445-455"},"PeriodicalIF":5.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chikungunya's global rebound and Asia's growing vulnerability: Implications for integrated vector control and pandemic preparedness.","authors":"Jing Ni, Zhifang Li, Xiaowei Hu, Hui Zhou, Zhenyu Gong","doi":"10.5582/bst.2025.01239","DOIUrl":"10.5582/bst.2025.01239","url":null,"abstract":"<p><p>Chikungunya fever is a mosquito-borne disease caused by an RNA virus of the Alphavirus genus and is characterized by fever and severe joint pain. The disease is primarily transmitted by Aedes aegypti and Ae. albopictus mosquitoes. Since its re-emergence in 2005, chikungunya has spread extensively, affecting more than 2.8 billion people across 119 countries worldwide. This article reviews the global epidemiological features of chikungunya, with a focus on its transmission dynamics, the characteristics of the virus and its vectors, as well as the influence of ecological and climatic factors. The article also discusses public health response measures, including the Wolbachia strategy, vaccine development, and integrated vector management. Despite China being a non-epidemic area, imported cases have led to localized outbreaks, prompting the implementation of the 'Four Pests-free Village' initiative to reduce mosquito density and improve public health. Notably, as of July 31, 2025, Guangdong Province in China has reported over 5,158 chikungunya cases and has initiated a Level 3 emergency response in the City of Foshan. In the face of global challenges such as climate change and the spread of invasive species, establishing a normalized rapid response system and enhancing monitoring, early warning, and inter-departmental collaboration are crucial to controlling the spread of mosquito-borne diseases and protecting public health.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"404-409"},"PeriodicalIF":5.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From dengue to chikungunya: Guangdong as a sentinel for arboviral threats in East Asia.","authors":"Yong Feng, Fangfang Chang, Yang Yang, Hongzhou Lu","doi":"10.5582/bst.2025.01228","DOIUrl":"10.5582/bst.2025.01228","url":null,"abstract":"<p><p>Chikungunya virus (CHIKV), an emerging mosquito-borne alphavirus, poses an escalating global public health threat due to its rapid geographic expansion and increasing outbreak frequency. While most infections present with acute fever and severe polyarthralgia, a significant proportion of patients develop chronic, disabling joint symptoms. Recent local transmission in subtropical urban regions of China, and particularly Guangdong Province, where over 4,800 cases were reported in Foshan alone by July 2025, highlights the virus's adaptability to new environments. Globally, over 220,000 cases and 80 deaths were reported in the first half of 2025 across 14 countries, with Brazil accounting for the majority of the reported cases. Climate factors, viral evolution, and human mobility are major drivers of the virus' spread. Despite the growing threat, no specific antiviral treatment or licensed vaccine is currently available. An effective response requires integrated strategies combining vaccine development, vector control, early warning systems, and climate-adaptive public health planning to mitigate further transmission and its health and socioeconomic impact.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"368-373"},"PeriodicalIF":5.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conversion therapy followed by surgery and adjuvant therapy improves survival in Barcelona C stage hepatocellular carcinoma - A propensity score-matched analysis.","authors":"Yinbiao Cao, Liru Pan, Zikun Ran, Wenwen Zhang, Junfeng Li, Xuerui Li, Tianyu Jiao, Zhe Liu, Tao Wan, Haowen Tang, Shichun Lu","doi":"10.5582/bst.2025.01162","DOIUrl":"10.5582/bst.2025.01162","url":null,"abstract":"<p><p>Conversion therapy with a combination of tyrosine kinase inhibitor and anti-programmed death-1 antibody sequential surgery and postoperative adjuvant therapy has shown improved survival benefits in patients with Barcelona C stage (BCLC-C) hepatocellular carcinoma (HCC). We aimed to compare the survival benefits in a retrospective cohort of patients with BCLC-C HCC who underwent surgery after conversion therapy with adjuvant therapy and surgery alone. The conversion therapy group was derived from a prospective clinical study, and from January 2015 to September 2023, we selected patients diagnosed with BCLC-C HCC who underwent liver resection at Chinese PLA General Hospital as the surgical group. The primary endpoint in the comparison of survival benefits between conversion therapy and surgery-alone groups was recurrence-free survival. Propensity score matching was applied to reduce any potential bias in the study. By the end of follow-up, the conversion therapy group mRFS was 37.8 months, with postoperative 1-, 2- and 3-year RFS rates of 66.8%, 54.6%, and 48.3%. In the surgery group, the mRFS was 3.0 months, and postoperative 1- , 2- and 3-year RFS rates of 22.4%, 17.5%, and 15.0%, respectively. On multivariable Cox regression analyses, conversion therapy significantly reduced HCC-related mortality and HCC recurrence rates compared with surgery alone. For BCLC-C HCC patients, conversion therapy with adjuvant therapy is in relationship with increased survival in comparison with surgery alone.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"432-444"},"PeriodicalIF":5.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144727748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival benefit of adjuvant chemotherapy and individualized prognosis in resected cHCC-CCA.","authors":"Bo Sun, Yimeng Wang, Ruyu Han, Yuren Xia, Meng Zhao, Liyu Sun, Xiaochen Ma, Tianqiang Song, Xiangdong Tian, Wenchen Gong, Lu Chen","doi":"10.5582/bst.2025.01178","DOIUrl":"10.5582/bst.2025.01178","url":null,"abstract":"<p><p>Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare malignancy with poor prognosis and unclear benefit from adjuvant chemotherapy. To identify the appropriate candidates for postoperative adjuvant chemotherapy in cHCC-CCA, we developed a prognostic model to predict patient outcomes and stratify populations accordingly. This retrospective study included 75 cHCC-CCA patients treated at Tianjin Medical University Cancer Institute and Hospital from 2009 to 2019. Prognostic factors were identified via univariate and multivariate Cox regression. Model performance was assessed using ROC curves, calibration plots, and decision curve analysis. Propensity score matching (PSM) was applied to reduce bias. Adjuvant chemotherapy significantly improved overall survival (OS) in Kaplan-Meier (p = 0.029) and PSM analyses (p = 0.0011). Five independent prognostic factors were identified: macrovascular invasion, lymph node metastasis, the largest tumor size >5 cm, the high expression of CD8, and the high expression of FOXP3. The nomogram showed good predictive performance. Among high-risk patients stratified by the nomogram, those receiving adjuvant chemotherapy had longer OS (p = 0.013), while no significant benefit was observed in the low-risk group (p = 0.084). Adjuvant chemotherapy improves postoperative survival in cHCC-CCA. The nomogram provides individualized risk stratification and may inform treatment decisions.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"421-431"},"PeriodicalIF":5.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiotherapy enhances triple therapy for conversion and survival in patients with unresectable hepatocellular carcinoma with portal vein tumor thrombus.","authors":"Ying Zhou, Minghong Yao, Tianfu Wen, Chuan Li","doi":"10.5582/bst.2025.01170","DOIUrl":"10.5582/bst.2025.01170","url":null,"abstract":"<p><p>Triple therapy (TT), consisting of transarterial chemoembolization, immune checkpoint inhibitors, and tyrosine kinase inhibitors, is recommended as a conversion therapy for patients with unresectable hepatocellular carcinoma (uHCC). However, patients with uHCC with portal vein tumor thrombosis (PVTT) have a limited response to TT alone. This study evaluated whether combining TT with radiotherapy (TTR) could increase conversion resection rates and improve the prognosis of uHCC with PVTT. A total of 123 patients treated at our institution from 2020-2024 were retrospectively analyzed, comprising 103 patients receiving TT and 20 receiving TTR. The overlap weighting (OW) method was used to minimize bias. Compared with the TT group, patients in the TTR group had a significantly greater early tumor shrinkage rate (85.0% vs. 59.2%, p = 0.029). Moreover, conversion resection rates were significantly higher in the TTR group (65.0% vs. 35.0%, p = 0.012), and the median overall survival (OS) was notably prolonged (median OS not reached vs. 31.9 months, p = 0.031). Following OW adjustment of the data, we obtained similar results. Multivariate analysis confirmed TTR as an independent protective factor for both OS (HR = 0.354, 95% CI = 0.127-0.984, p = 0.046) and the conversion resection rate (OR = 0.261, 95% CI = 0.081-0.838, p = 0.024). Treatment-related adverse events were manageable. Thus, TTR offers an improved conversion resection rate and survival outcomes compared with TT alone in patients with uHCC with PVTT and represents a promising therapeutic strategy.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"468-478"},"PeriodicalIF":5.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new strategy of laparoscopic anatomical right hemihepatectomy via a hepatic parenchymal transection-first approach guided by the middle hepatic vein.","authors":"Nan You, Yongkun Li, Qifan Zhang, Chaoqun Wang, Ke Wu, Zheng Wang, Qian Ren, Jing Li, Lu Zheng","doi":"10.5582/bst.2025.01040","DOIUrl":"10.5582/bst.2025.01040","url":null,"abstract":"<p><p>Laparoscopic anatomical right hemihepatectomy (LARH) is a highly challenging procedure due to the lack of an appropriate surgical approach. This study aimed to investigate the safety and efficacy of LARH via a hepatic parenchymal transection-first approach (HPF) guided by the middle hepatic vein (MHV) (HPFM) to treat hepatocellular carcinoma (HCC) by comparison with the extrahepatic Glissonian approach (EG). Between January 2017 and December 2019, a total of 105 HCC patients who underwent LARH, of whom 48 underwent HPFM, were included in this study. After a 1:1 propensity score matching, 41 LARH-HPFM were compared to 41 LARH-EG. We have analyzed perioperative and oncologic outcomes of the two different operative approaches for HCC treatments. Quality of two operative approaches was defined by textbook outcome (TO). The LARH-HPF group was associated with shorter mean operative time (P = 0.029) and less blood loss (P = 0.023). The LARH-HPFM did not increase the postoperative overall complication rates (P = 0.248) when compared with the LARH-EG. The results of univariable and multivariable analyses indicated that LARH-HPFM provided a clinical benefit for operative time and blood loss. In addition, patients who received LARH-HPFM cumulated more TO criteria (P = 0.017), and achieved higher rate of TO (46.3% vs. 24.4%; 2.68, 95% CI 1.05 - 6.86, P = 0.040) compared with those who received LARH-EG. These findings indicate LARH-HPFM is safe and feasible for HCC with certain advantages over LARH-EG, but there are still many problems worth further exploration.</p>","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"456-467"},"PeriodicalIF":5.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}