Bioscience trends最新文献_第2页

Evaluation of the value of Synechococcus 7942 as a sensitizer for photo-sonodynamic therapy against breast cancer. 评估 Synechococcus 7942 作为光-声动力学疗法抗乳腺癌增敏剂的价值。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2024-09-16 Epub Date: 2024-08-22 DOI: 10.5582/bst.2024.01211

Ruimei Zhao, Pengfei Zhao, Ziyuan Zhou, Deliang Liu, Yang Zhou, Mingbin Zheng, Tetsuya Asakawa, Xin Kuang

{"title":"Evaluation of the value of Synechococcus 7942 as a sensitizer for photo-sonodynamic therapy against breast cancer.","authors":"Ruimei Zhao, Pengfei Zhao, Ziyuan Zhou, Deliang Liu, Yang Zhou, Mingbin Zheng, Tetsuya Asakawa, Xin Kuang","doi":"10.5582/bst.2024.01211","DOIUrl":"10.5582/bst.2024.01211","url":null,"abstract":"This study was conducted to investigate the value of Synechococcus 7942 (Syne) as a sensitizer for photo-sonodynamic therapy (PSDT). Syne was characterized. The efficacy of Syne-mediated PSDT were verified in vitro (in 4T1 breast cancer cells) and in vivo (in a breast tumor-bearing mouse model). The safety of Syne-mediated PSDT was verified in vivo. Results indicated that Syne triggered the generation of oxygen and ROS during PSDT, thereby inducing cell death in 4T1 cells. Syne-mediated PSDT induced the death of tumor cells both in vitro and in vivo. The speed of tumor growth was delayed in animals receiving PSDT. Syne-mediated PSDT was more effective than photodynamic therapy or sonodynamic therapy alone. In addition, administration of a Syne monomer resulted in satisfactory tumor targeting. Syne-mediated PSDT affected neither the animal body weight nor the major organs, indicating satisfactory safety. Accordingly, Syne is an efficient, safe, and readily available sensitizer that is ideal for potential clinical use of PSDT to treat breast cancer. The findings of this study are useful for exploration of a novel sensitizer for PSDT, which might be a promising alternative therapy against breast cancer.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential value and advances in research on bone mineral density (BMD) measurement in the auxiliary clinical assessment of hepatocellular carcinoma. 骨矿物质密度 (BMD) 测量在肝细胞癌辅助临床评估中的潜在价值和研究进展。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2024-09-16 Epub Date: 2024-08-22 DOI: 10.5582/bst.2024.01235

Xudong Zhang, Lu Chen, Peipei Song, Chunfu Zhu, Liming Tang

{"title":"Potential value and advances in research on bone mineral density (BMD) measurement in the auxiliary clinical assessment of hepatocellular carcinoma.","authors":"Xudong Zhang, Lu Chen, Peipei Song, Chunfu Zhu, Liming Tang","doi":"10.5582/bst.2024.01235","DOIUrl":"10.5582/bst.2024.01235","url":null,"abstract":"Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer death worldwide and its prognosis is highly heterogeneous, being related not only to underlying chronic liver disease but also to the severity of cancer cachexia. Nutritional factors play a crucial role in influencing the prognosis of HCC. Despite musculoskeletal imbalance being consistently reported as a predictor of perioperative mortality in patients with HCC, this condition is often overlooked in clinical management. Bone mineral density (BMD), which serves as a marker of nutritional status, can be assessed through CT by measuring the pixel density of the vertebral bone. Recent clinical studies have indicated that BMD serves not only as a significant risk factor for development of HCC in cirrhotic patients but also potentially functions as an independent prognostic indicator for post-treatment outcomes in patients with HCC. Preoperative abdominal CT scans provide a convenient and cost-effective method to measure BMD, offering significant assistance in prognostic evaluation of patients with HCC. A thorough grasp of the liver-bone connection, along with the conduct of higher-quality studies and the establishment of standardized methods and cutoff values for BMD measurement, could enhance approaches to manage HCC.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revealing the enhancement effect of social capital on the individual performance of core members in elderly caring organizations: A study from Anhui, China. 揭示社会资本对养老机构核心成员个人绩效的提升作用：来自中国安徽的研究。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2024-07-09 Epub Date: 2024-06-12 DOI: 10.5582/bst.2024.01069

Shuo Ding, Fuqin Xu, Guoqing Liu, Xin Zheng, Lanlan Zhao, Otsen Benjamin, Ziwen Xu, Jiajie Zhao, Sanyuan Hao, Ren Chen

{"title":"Revealing the enhancement effect of social capital on the individual performance of core members in elderly caring organizations: A study from Anhui, China.","authors":"Shuo Ding, Fuqin Xu, Guoqing Liu, Xin Zheng, Lanlan Zhao, Otsen Benjamin, Ziwen Xu, Jiajie Zhao, Sanyuan Hao, Ren Chen","doi":"10.5582/bst.2024.01069","DOIUrl":"10.5582/bst.2024.01069","url":null,"abstract":"Aging is a challenge to global development. This challenge is particularly significant for China because it has the largest elderly population worldwide. The proportion of aging population continues to increase, and solely relying on government efforts to meet the needs of the elderly is inadequate. Hence, involvement of social organizations in elderly care services is needed. Their core members exhibit higher sense of responsibility and identification with the organization than regular members, thus profoundly affecting organizational development. Based on the Social Capital Theory, this study employed a multistage stratified random sampling method to examine the social capital stock of elderly social organizations and their core members across six cities in Anhui Province, China. Chi-square tests analyzed the relationship between the core members' demographic factors and individual performance. Independent-sample t-tests assessed the relationship between social capital and individual performance. Finally, binary logistic regression models determined the factors influencing the individual performance of core members. Social networks within core members' social capital and the internal social capital of elderly caring social organizations (ESOs) affect the individual performance of core members. Therefore, organizations should provide more training opportunities for core members to expand their networks. Cultivating a shared language and vision as components of social capital can enhance organizational cohesion and operational stability.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141309939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishment of nomogram prediction model of contrast-enhanced ultrasound and Gd-EOB-DTPA-enhanced MRI for vessels encapsulating tumor clusters pattern of hepatocellular carcinoma. 建立造影剂增强超声波和 Gd-EOB-DTPA 增强 MRI 对肝细胞癌血管包裹肿瘤簇模式的提名图预测模型

IF 5.7 4区生物学

Bioscience trends Pub Date : 2024-07-09 Epub Date: 2024-06-12 DOI: 10.5582/bst.2024.01112

Feiqian Wang, Kazushi Numata, Akihiro Funaoka, Xi Liu, Takafumi Kumamoto, Kazuhisa Takeda, Makoto Chuma, Akito Nozaki, Litao Ruan, Shin Maeda

{"title":"Establishment of nomogram prediction model of contrast-enhanced ultrasound and Gd-EOB-DTPA-enhanced MRI for vessels encapsulating tumor clusters pattern of hepatocellular carcinoma.","authors":"Feiqian Wang, Kazushi Numata, Akihiro Funaoka, Xi Liu, Takafumi Kumamoto, Kazuhisa Takeda, Makoto Chuma, Akito Nozaki, Litao Ruan, Shin Maeda","doi":"10.5582/bst.2024.01112","DOIUrl":"10.5582/bst.2024.01112","url":null,"abstract":"To establish clinical prediction models of vessels encapsulating tumor clusters (VETC) pattern using preoperative contrast-enhanced ultrasound (CEUS) and gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid magnetic resonance imaging (EOB-MRI) in patients with hepatocellular carcinoma (HCC). A total of 111 resected HCC lesions from 101 patients were included. Preoperative imaging features of CEUS and EOB-MRI, postoperative recurrence, and survival information were collected from medical records. The best subset regression and multivariable Cox regression were used to select variables to establish the prediction model. The VETC-positive group had a statistically lower survival rate than the VETC-negative group. The selected variables were peritumoral enhancement in the arterial phase (AP), hepatobiliary phase (HBP) on EOB-MRI, intratumoral branching enhancement in the AP of CEUS, intratumoral hypoenhancement in the portal phase of CEUS, incomplete capsule, and tumor size. A nomogram was developed. High and low nomogram scores with a cutoff value of 168 points showed different recurrence-free survival rates and overall survival rates. The area under the curve (AUC) and accuracy were 0.804 and 0.820, respectively, indicating good discrimination. Decision curve analysis showed a good clinical net benefit (threshold probability > 5%), while the Hosmer-Lemeshow test yielded excellent calibration (P = 0.6759). The AUC of the nomogram model combining EOB-MRI and CEUS was higher than that of the models with EOB-MRI factors only (0.767) and CEUS factors only (0.7). The nomogram verified by bootstrapping showed AUC and calibration curves similar to those of the nomogram model. The Prediction model based on CEUS and EOB-MRI is effective for preoperative noninvasive diagnosis of VETC.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141309938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The latest policies, practices, and hotspots in research in conjunction with the aging of Japan's population. 与日本人口老龄化相关的最新政策、实践和研究热点。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2024-07-09 Epub Date: 2024-06-12 DOI: 10.5582/bst.2024.01150

Yuan Liu, Susumu Kobayashi, Kenji Karako, Peipei Song, Wei Tang

{"title":"The latest policies, practices, and hotspots in research in conjunction with the aging of Japan's population.","authors":"Yuan Liu, Susumu Kobayashi, Kenji Karako, Peipei Song, Wei Tang","doi":"10.5582/bst.2024.01150","DOIUrl":"10.5582/bst.2024.01150","url":null,"abstract":"Population aging is a global concern, and Japan currently has the world's highest proportion of an aging population. In 2020, the population age 65 and over accounted for 10% of the global population, while this proportion was 29% in Japan, and it is expected to reach 38.4% in 2065. The average life expectancy in Japan in 2022 was 81.05 for males and 87.09 for females. At the same time, Japan's healthy life expectancy continues to increase, and it is increasing at a faster rate than the average life expectancy, with males expected to live 72.68 years and females expected to live 75.38 years in 2019. This is causing the social role of elderly people in Japan to constantly change. The Japanese Government continues to adjust its policy orientation, to improve the health level and social participation of the elderly, improve the accessibility of long-term nursing services and the treatment of nursing professionals, and improve the pension system. By 2025, one-fifth of people in Japan are expected to suffer from dementia. Japan has implemented a series of policies to create a dementia-inclusive and less risky society. The proportion of the population ages 65 and over living alone in Japan increased from 4.3% among males and from 11.2% among females in 1980 to 15.0% among males and 22.1% among females in 2020, representing a sustained increase. Changes in the composition of the population have prompted sustained attention to the personalization and diversification of elderly care. At the same time, Japanese researchers continue to utilize scientific and information technology to innovate elderly care products, improve the efficiency of elderly care, and provide intelligent elderly care.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141309940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integration of wearable devices and deep learning: New possibilities for health management and disease prevention. 可穿戴设备与深度学习的整合：健康管理和疾病预防的新可能。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2024-07-09 Epub Date: 2024-06-27 DOI: 10.5582/bst.2024.01170

Kenji Karako

{"title":"Integration of wearable devices and deep learning: New possibilities for health management and disease prevention.","authors":"Kenji Karako","doi":"10.5582/bst.2024.01170","DOIUrl":"10.5582/bst.2024.01170","url":null,"abstract":"In recent years, the market for wearable devices has been rapidly growing, with much of the demand for health management. These devices are equipped with numerous sensors that detect inertial measurements, electrocardiograms, photoplethysmography signals, and more. Utilizing the collected data enables the monitoring and analysis of the user's health status in real time. With the proliferation of wearable devices, research on applications such as human activity recognition, anomaly detection, and disease prediction has advanced by combining these devices with deep learning technology. Analyzing heart rate variability and activity data, for example, enables the early detection of an abnormal health status and prompt, appropriate medical interventions. Much of the current research focuses on short-term predictions, but adopting a long-term perspective is essential for further development of wearable devices and deep learning. Continuously recording user behavior, anomalies, and physical information and collecting and analyzing data over an extended period will enable more accurate disease predictions and lifestyle guidance based on individual habits and physical conditions. Achieving this requires the integration of wearable devices with medical records. A system needs to be created to integrate data collected by wearable devices with medical records such as electronic health records in collaboration with medical facilities like hospitals and clinics. Overcoming this challenge will enable optimal health management and disease prediction for each user, leading to a higher quality of life.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141455130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A predictive radiotranscriptomics model based on DCE-MRI for tumor immune landscape and immunotherapy in cholangiocarcinoma. 基于 DCE-MRI 的放射转录组学模型，用于预测胆管癌的肿瘤免疫格局和免疫疗法。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2024-07-09 Epub Date: 2024-06-10 DOI: 10.5582/bst.2024.01121

Lu Chen, Guotao Yin, Ziyang Wang, Zifan Liu, Chunxiao Sui, Kun Chen, Tianqiang Song, Wengui Xu, Lisha Qi, Xiaofeng Li

{"title":"A predictive radiotranscriptomics model based on DCE-MRI for tumor immune landscape and immunotherapy in cholangiocarcinoma.","authors":"Lu Chen, Guotao Yin, Ziyang Wang, Zifan Liu, Chunxiao Sui, Kun Chen, Tianqiang Song, Wengui Xu, Lisha Qi, Xiaofeng Li","doi":"10.5582/bst.2024.01121","DOIUrl":"10.5582/bst.2024.01121","url":null,"abstract":"This study aims to determine the predictive role of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) derived radiomic model in tumor immune profiling and immunotherapy for cholangiocarcinoma. To perform radiomic analysis, immune related subgroup clustering was first performed by single sample gene set enrichment analysis (ssGSEA). Second, a total of 806 radiomic features for each phase of DCE-MRI were extracted by utilizing the Python package Pyradiomics. Then, a predictive radiomic signature model was constructed after a three-step features reduction and selection, and receiver operating characteristic (ROC) curve was employed to evaluate the performance of this model. In the end, an independent testing cohort involving cholangiocarcinoma patients with anti-PD-1 Sintilimab treatment after surgery was used to verify the potential application of the established radiomic model in immunotherapy for cholangiocarcinoma. Two distinct immune related subgroups were classified using ssGSEA based on transcriptome sequencing. For radiomic analysis, a total of 10 predictive radiomic features were finally identified to establish a radiomic signature model for immune landscape classification. Regarding to the predictive performance, the mean AUC of ROC curves was 0.80 in the training/validation cohort. For the independent testing cohort, the individual predictive probability by radiomic model and the corresponding immune score derived from ssGSEA was significantly correlated. In conclusion, radiomic signature model based on DCE-MRI was capable of predicting the immune landscape of chalangiocarcinoma. Consequently, a potentially clinical application of this developed radiomic model to guide immunotherapy for cholangiocarcinoma was suggested.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141295457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent trends and new developments in liver transplantation. 肝脏移植的最新趋势和发展。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2024-07-09 Epub Date: 2024-06-29 DOI: 10.5582/bst.2024.01176

Yasuhiko Sugawara, Taizo Hibi

引用次数: 0

Revealing the gut microbiome mystery: A meta-analysis revealing differences between individuals with autism spectrum disorder and neurotypical children. 揭开肠道微生物组的神秘面纱：揭示自闭症谱系障碍患者与神经正常儿童之间差异的荟萃分析。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2024-07-09 Epub Date: 2024-06-18 DOI: 10.5582/bst.2024.01123

Changjiang Yang, Hongli Xiao, Han Zhu, Yijie Du, Ling Wang

{"title":"Revealing the gut microbiome mystery: A meta-analysis revealing differences between individuals with autism spectrum disorder and neurotypical children.","authors":"Changjiang Yang, Hongli Xiao, Han Zhu, Yijie Du, Ling Wang","doi":"10.5582/bst.2024.01123","DOIUrl":"10.5582/bst.2024.01123","url":null,"abstract":"The brain-gut axis intricately links gut microbiota (GM) dysbiosis to the development or worsening of autism spectrum disorder (ASD). However, the precise GM composition in ASD and the effectiveness of probiotics are unclear. To address this, we performed a thorough meta-analysis of 28 studies spanning PubMed, PsycINFO, Web of Science, Scopus, and MEDLINE, involving 1,256 children with ASD and 1042 neurotypical children, up to February 2024. Using Revman 5.3, we analyzed the relative abundance of 8 phyla and 64 genera. While individuals with ASD did not exhibit significant differences in included phyla, they exhibited elevated levels of Parabacteroides, Anaerostipes, Faecalibacterium, Clostridium, Dorea, Phascolarctobacterium, Lachnoclostridium, Catenibacterium, and Collinsella along with reduced percentages of Barnesiella, Odoribacter, Paraprevotella, Blautia, Turicibacter, Lachnospira, Pseudomonas, Parasutterella, Haemophilus, and Bifidobacterium. Notably, discrepancies in Faecalibacterium, Clostridium, Dorea, Phascolarctobacterium, Catenibacterium, Odoribacter, and Bifidobacterium persisted even upon systematic exclusion of individual studies. Consequently, the GM of individuals with ASD demonstrates an imbalance, with potential increases or decreases in both beneficial and harmful bacteria. Therefore, personalized probiotic interventions tailored to ASD specifics are imperative, rather than a one-size-fits-all approach.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suppression of STK39 weakens the MASLD/MASH process by protecting the intestinal barrier. 抑制 STK39 可以保护肠道屏障，从而削弱 MASLD/MASH 进程。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2024-07-09 Epub Date: 2024-06-26 DOI: 10.5582/bst.2024.01097

Qing Xu, Fei Liu, Zhenru Wu, Menglin Chen, Yongjie Zhou, Yujun Shi

{"title":"Suppression of STK39 weakens the MASLD/MASH process by protecting the intestinal barrier.","authors":"Qing Xu, Fei Liu, Zhenru Wu, Menglin Chen, Yongjie Zhou, Yujun Shi","doi":"10.5582/bst.2024.01097","DOIUrl":"10.5582/bst.2024.01097","url":null,"abstract":"STK39 is reportedly a critical negative regulator of intestinal barrier. Pharmacological targeting of STK39 is expected to protect the intestinal barrier and thereby weaken metabolic dysfunction-associated steatohepatitis (MASH); Proximal colon biopsy tissues from patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and those without MASLD were analyzed for STK39 expression. Wildtype (WT) mice and systemic STK39 gene knockout (STK39-/-) male mice were fed a normal diet or a high-fat methionine-choline deficient diet (HFMCD) for 8 weeks. The MASH mice were grouped and treated with ZT-1a (a STK39 inhibitor) or vehicle intraperitoneal injection during the procedure of HFMCD induction. Liver and intestinal tissues were collected for further examination; Colon tissues from patients with MASLD exhibited higher levels of STK39 than those from subjects without MASLD. Knockout of STK39 diminished CD68+ Kupffer cells and α-SMA+ hepatic stellate cells infiltration in mouse MASH model. Treatment with ZT-1a also prevented severe steatohepatitis in a mouse MASH model, including milder histological and pathological manifestations (lobular inflammation and fibrosis) in the liver. Interestingly, Inhibition of STK39 had minimal effects on hepatic lipid metabolism. The reduced liver injury observed in mice with STK39 inhibition was linked to significant decreases in mucosal inflammation, tight junction disruption and intestinal epithelial permeability to bacterial endotoxins; Collectively, we have revealed that inhibiting STK39 prevents the progression of MASH by protecting the intestinal epithelial barrier.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141455131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0