Bioscience trends最新文献_第2页

Advancing precision medicine in immune checkpoint blockade for HIV/AIDS: Current strategies and future directions. 推进艾滋病免疫检查点阻断的精准医学：当前策略和未来方向。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2025-04-29 DOI: 10.5582/bst.2025.01072

Xiangyi Tang, Cheng Wang, Xiling Zhang, Qibin Liao, Hongzhou Lu

{"title":"Advancing precision medicine in immune checkpoint blockade for HIV/AIDS: Current strategies and future directions.","authors":"Xiangyi Tang, Cheng Wang, Xiling Zhang, Qibin Liao, Hongzhou Lu","doi":"10.5582/bst.2025.01072","DOIUrl":"https://doi.org/10.5582/bst.2025.01072","url":null,"abstract":"Acquired immunodeficiency syndrome (AIDS)/human immunodeficiency virus (HIV) patients experience significant increase in their survival and decline in the mortality with the advent of antiretroviral therapy (ART). Nonetheless, ART alone still cannot completely cure AIDS/HIV patients. Furthermore, the virus remains latent in resting CD4+T cells for extended periods, posing a continuous threat to AIDS/HIV patients. Immune checkpoint blockades (ICBs), as a promising immunotherapy, inaugurate new pathways for AIDS/HIV cure or remission given their capability to break down the latency limit of HIV, and promote the regeneration and activation of HIV-specific T cells. However, not all AIDS/HIV patients respond to immune checkpoint inhibitors (ICIs), similar to that encountered in cancer patients, accompanied by the risk of severe immune-related adverse events (irAEs) in some cases. Accordingly, the present study was conducted to explore the possibility of personalized medicine tailored to the host discrepancy, with purposes of achieving better treatment outcomes, higher objective response rates, and fewer irAEs. Strategies for ICIs based on individual differences are documented to be conducive to improving therapeutic outcomes for patients. Therefore, this study intended to improving the therapeutic efficacy of ICIs in AIDS/HIV patients within the context of precision immunotherapy, including monotherapy and combination strategies, as well as the application of predictive biomarkers.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Promoting active health with AI technologies: Current status and prospects of high-altitude therapy, simulated hypoxia, and LLM-driven lifestyle rehabilitation approaches. 用人工智能技术促进积极健康：高原治疗、模拟缺氧和llm驱动的生活方式康复方法的现状和前景

IF 5.7 4区生物学

Bioscience trends Pub Date : 2025-04-29 DOI: 10.5582/bst.2025.01105

Mingyu Liu, Wenli Zhang, Junyu Wang, Kehan Bao, Ziyi Fu, Boyuan Wang

{"title":"Promoting active health with AI technologies: Current status and prospects of high-altitude therapy, simulated hypoxia, and LLM-driven lifestyle rehabilitation approaches.","authors":"Mingyu Liu, Wenli Zhang, Junyu Wang, Kehan Bao, Ziyi Fu, Boyuan Wang","doi":"10.5582/bst.2025.01105","DOIUrl":"https://doi.org/10.5582/bst.2025.01105","url":null,"abstract":"In the context of the rising global prevalence of obesity, traditional intervention measures have proven insufficient to meet the demands of personalized and sustainable health management, necessitating the exploration of innovative solutions through innovative technologies. This study explores how advanced digital technologies, including Internet of Things (IoT) and Artificial Intelligence (AI), can manage weight and enhance full-lifecycle health in individuals with obesity under simulated high-altitude hypoxic conditions (HC). The findings suggest that integrating simulated HC with digital health technologies offers a novel and safe approach to obesity rehabilitation. By leveraging environmental stimuli, real-time monitoring through wearable devices, and intelligent evaluation using large language models (LLMs), this method enables more scientific weight loss, prevents rebound weight gain, and fosters proactive healthy lifestyles, significantly improving weight control outcomes for individuals with obesity. Future research should evaluate the efficacy of simulated HC in weight management and its long-term impact on obesity control. Establishing an integrated framework that combines simulated HC, lifestyle interventions, and smart health ecosystems is crucial for advancing rehabilitative healthcare and addressing the global burden of obesity through digital innovation.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet count as a double-edged sword: The impact of thrombocytosis and thrombocytopenia on long-term outcomes after hepatic resection for hepatocellular carcinoma. 血小板计数是一把双刃剑：血小板增多和血小板减少对肝癌肝切除术后长期预后的影响。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2025-04-22 DOI: 10.5582/bst.2025.01067

Xuedong Wang, Pengfei Wang, Bingjun Tang, Jiahao Xu, Baidong Wang, Lihui Gu, Yingjian Liang, Hongwei Guo, Han Liu, Yifan Wu, Hong Wang, Yahao Zhou, Yongyi Zeng, Yongkang Diao, Lanqing Yao, Mingda Wang, Chao Li, Timothy M Pawlik, Feng Shen, Lei Cai, Tian Yang

{"title":"Platelet count as a double-edged sword: The impact of thrombocytosis and thrombocytopenia on long-term outcomes after hepatic resection for hepatocellular carcinoma.","authors":"Xuedong Wang, Pengfei Wang, Bingjun Tang, Jiahao Xu, Baidong Wang, Lihui Gu, Yingjian Liang, Hongwei Guo, Han Liu, Yifan Wu, Hong Wang, Yahao Zhou, Yongyi Zeng, Yongkang Diao, Lanqing Yao, Mingda Wang, Chao Li, Timothy M Pawlik, Feng Shen, Lei Cai, Tian Yang","doi":"10.5582/bst.2025.01067","DOIUrl":"https://doi.org/10.5582/bst.2025.01067","url":null,"abstract":"The prognostic significance of preoperative platelet counts among patients with hepatocellular carcinoma (HCC) undergoing curative resection remains controversial. The objective of the current study was to investigate the impact of preoperative platelet count on long-term outcomes after HCC resection. Patients who underwent curative-intent resection for HCC between 2000 and 2021 at 10 hepatobiliary centers in China were retrospectively analyzed. Patients were categorized based on platelet count within 2 weeks before surgery: thrombocytopenia (< 100 × 109/L), normal platelet count (100-299 × 109/L), and thrombocytosis (≥ 300 × 109/L). The primary outcomes were overall survival (OS) and recurrence-free survival (RFS). Among 3,116 patients, 655 (21.0%) had thrombocytopenia, 2,374 (76.2%) had normal platelet counts, and 87 (2.8%) had thrombocytosis. The 5-year OS was 52.7%, 56.0%, and 40.2% for thrombocytopenia, normal platelet count, and thrombocytosis groups, respectively (p < 0.001 among the three groups); the corresponding 5-year RFS was 39.3%, 39.3%, and 26.9%, respectively (p = 0.001 among the three groups). Multivariable analysis identified both thrombocytopenia (HR 1.215, 95% CI 1.045-1.413, p = 0.011) and thrombocytosis (HR 1.307, 95% CI 1.130-1.511, p < 0.001) as independent risk factors for worse OS, and thrombocytosis was independently associated with worse RFS (HR 1.523, 95% CI 1.196-1.939, p = 0.001). Both thrombocytopenia and thrombocytosis were associated with worse survival after HCC resection, with thrombocytosis also predicting higher risk of recurrence. Routine preoperative platelet count may serve as a valuable and practical prognostic marker for risk stratification among patients with HCC undergoing resection.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current status and perspectives of molecular mechanisms of gender difference in hepatocellular carcinoma: The tip of the iceberg? 肝细胞癌性别差异分子机制的现状与展望：冰山一角？

IF 5.7 4区生物学

Bioscience trends Pub Date : 2025-04-22 DOI: 10.5582/bst.2025.01103

Zhi-Quan Xu, Shi-Qiao Luo, Zhong-Jun Wu, Rui Liao

{"title":"Current status and perspectives of molecular mechanisms of gender difference in hepatocellular carcinoma: The tip of the iceberg?","authors":"Zhi-Quan Xu, Shi-Qiao Luo, Zhong-Jun Wu, Rui Liao","doi":"10.5582/bst.2025.01103","DOIUrl":"https://doi.org/10.5582/bst.2025.01103","url":null,"abstract":"Hepatocellular carcinoma (HCC) risk factors and incidence vary globally, but men generally have higher incidence than women. Men also tend to have a worse prognosis in terms of survival period and pathological characteristics. Furthermore, there are notable gender differences in treatment strategies and drug responses. While traditional risk factors such as hepatitis B virus, hepatitis C virus, alcohol consumption, and metabolic syndrome contribute to these differences, the underlying molecular mechanisms remain partly understood. Recent research has focused on elucidating the roles of sex hormones, DNA damage and repair pathways, immune microenvironments, and genetic/epigenetic factors in driving gender-specific disparities. For instance, estrogen receptor signaling has been shown to suppress HCC progression, whereas androgen receptor signaling promotes tumor development. Additionally, immune cells such as tumor-associated macrophages and regulatory T cells exhibit gender-specific patterns, with males typically showing higher levels of immunosuppressive cells. Omics analyses, including genomics, transcriptomics, and proteomics, have further revealed sex-specific differences in gene expression, protein interactions, and metabolic pathways. Despite these advances, significant gaps remain in understanding the interplay between environmental, hormonal, and genetic factors in shaping gender disparities in HCC. Future research should prioritize the identification of novel molecular targets, the development of gender-specific therapeutic strategies, and the integration of multi-omics data to address these disparities. Addressing these challenges will be critical for improving diagnostic, prognostic, and therapeutic outcomes in HCC patients of both sexes.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrative neurorehabilitation using brain-computer interface: From motor function to mental health after stroke. 脑机接口综合神经康复：从脑卒中后的运动功能到心理健康。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2025-04-17 DOI: 10.5582/bst.2025.01109

Ya-Nan Ma, Kenji Karako, Peipei Song, Xiqi Hu, Ying Xia

{"title":"Integrative neurorehabilitation using brain-computer interface: From motor function to mental health after stroke.","authors":"Ya-Nan Ma, Kenji Karako, Peipei Song, Xiqi Hu, Ying Xia","doi":"10.5582/bst.2025.01109","DOIUrl":"https://doi.org/10.5582/bst.2025.01109","url":null,"abstract":"Stroke remains a leading cause of mortality and long-term disability worldwide, frequently resulting in impairments in motor control, cognition, and emotional regulation. Conventional rehabilitation approaches, while partially effective, often lack individualization and yield suboptimal outcomes. In recent years, brain-computer interface (BCI) technology has emerged as a promising neurorehabilitation tool by decoding neural signals and providing real-time feedback to enhance neuroplasticity. This review systematically explores the use of BCI systems in post-stroke rehabilitation, focusing on three core domains: motor function, cognitive capacity, and emotional regulation. This review outlines the neurophysiological principles underpinning BCI-based motor rehabilitation, including neurofeedback training, Hebbian plasticity, and multimodal feedback strategies. It then examines recent advances in upper limb and gait recovery using BCI integrated with functional electrical stimulation (FES), robotics, and virtual reality (VR). Moreover, it highlights BCI's potential in cognitive and language rehabilitation through EEG-based neurofeedback and the integration of artificial intelligence (AI) and immersive VR environments. In addition, it discusses the role of BCI in monitoring and regulating post-stroke emotional disorders via closed-loop systems. While promising, BCI technologies face challenges related to signal accuracy, device portability, and clinical validation. Future research should prioritize multimodal integration, AI-driven personalization, and large-scale randomized trials to establish long-term efficacy. This review underscores BCI's transformative potential in delivering intelligent, personalized, and cross-domain rehabilitation solutions for stroke survivors.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SNRPA promotes hepatocellular carcinoma proliferation and lenvatinib resistance via B7-H6-STAT3/AKT axis by facilitating B7-H6 pre-mRNA maturation. SNRPA通过B7-H6- stat3 /AKT轴促进B7-H6前mrna成熟，促进肝癌增殖和lenvatinib耐药。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2025-04-15 DOI: 10.5582/bst.2025.01036

Jiejun Hu, Junhua Gong, Xia Shu, Xin Dai, Dong Cai, Zhibo Zhao, Jinhao Li, Guochao Zhong, Jianping Gong

{"title":"SNRPA promotes hepatocellular carcinoma proliferation and lenvatinib resistance via B7-H6-STAT3/AKT axis by facilitating B7-H6 pre-mRNA maturation.","authors":"Jiejun Hu, Junhua Gong, Xia Shu, Xin Dai, Dong Cai, Zhibo Zhao, Jinhao Li, Guochao Zhong, Jianping Gong","doi":"10.5582/bst.2025.01036","DOIUrl":"https://doi.org/10.5582/bst.2025.01036","url":null,"abstract":"The pre-mRNAs splicing is important mechanisms of hepatocellular carcinoma (HCC) progression. Hence, this study aimed to explore the function and corresponding mechanisms of small nuclear ribonucleoprotein polypeptide A (SNRPA), a vital RNAs splicing molecule, in HCC. Here, the University of Alabama at Birmingham CANcer data analysis portal (UALCAN), western blotting, and immunohistochemistry indicated that SNRPA levels were elevated in HCC tissues. Moreover, high expression of SNRPA was correlated with unfavorable clinicopathologic features and poor survival in HCC patients. A series of in vitro and in vivo gain/loss-of-function experiments reported that SNRPA promoted the proliferation of HCC cells. Integrated nanopore full-length cDNA sequencing and RNA-binding protein immunoprecipitation sequencing revealed that B7 homologue 6 (B7-H6) was a potential target of SNRPA. Subsequently, western blotting and flow cytometry showed that SNRPA activated B7-H6-STAT3/AKT signaling axis in HCC cells with promotion of G1-S transition in the cell cycle and inhibition of cell apoptosis. Mechanistically, RNA-binding protein immunoprecipitation and polymerase chain reaction with using exon-exon and exon-intron junction primers revealed that SNRPA facilitated B7-H6 pre-mRNA maturation by binding to it directly and contributing to its intron 2 splicing. Moreover, drug sensitivity test found that SNRPA induced HCC cell resistance to lenvatinib. Finally, restoration experiments demonstrated that the effects of SNRPA on HCC cells relied on B7- H6 expression. Taken together, SNRPA promotes HCC growth and lenvatinib resistance via B7-H6-STAT3/AKT axis through facilitating B7-H6 pre-mRNA maturation by maintaining its intron 2 splicing. Thus, SNRPA may be a promising target for HCC therapy and lenvatinib resistance reversion.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver exposure during laparoscopic right-sided hepatectomy via stretching of the ligamentum teres hepatis: A propensity score matching analysis. 经肝圆韧带拉伸的腹腔镜右侧肝切除术中肝脏暴露：倾向评分匹配分析。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2025-04-09 DOI: 10.5582/bst.2025.01044

Keda Song, Yang Xu, Zhongyu Li, Mingyuan Wang, Dong Chen, Yongzhi Zhou, Guangchao Yang, Yong Ma

{"title":"Liver exposure during laparoscopic right-sided hepatectomy via stretching of the ligamentum teres hepatis: A propensity score matching analysis.","authors":"Keda Song, Yang Xu, Zhongyu Li, Mingyuan Wang, Dong Chen, Yongzhi Zhou, Guangchao Yang, Yong Ma","doi":"10.5582/bst.2025.01044","DOIUrl":"https://doi.org/10.5582/bst.2025.01044","url":null,"abstract":"One of the challenges of laparoscopic liver resection (LLR) is the exposure of the surgical field. We propose a new surgical approach to better expose the right liver, stretching of the ligamentum teres hepatis (SLTH), and we evaluated its clinical feasibility and limitations through a study analyzing relevant cases. Clinicopathologic data on patients who underwent laparoscopic right partial hepatectomy (LRPH) at our center were retrospectively collected, and subjects were 276 patients with liver space-occupying lesions who met the selection criteria and who underwent the new surgical approach (SLTH) or the conventional surgical approach (no stretching of the ligamentum teres hepatis, or NSLTH). After 1:1 propensity score matching (PSM), 102 patients in each cohort were selected for further analysis. There were no significant differences in the operating time or the duration of postoperative hospitalization between the SLTH cohort and the NSLTH cohort. The duration of detachment of the hepatic parenchyma and the duration of hepatic portal occlusion were significantly shorter in the SLTH cohort than in the NSLTH cohort. The intraoperative blood loss in the SLTH cohort was significantly less than that in the NSLTH cohort. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were significantly lower in the SLTH cohort than in the NSLTH cohort on day 5 postoperatively. Results confirmed that SLTH is a simple, safe, effective, and highly reproducible technique for the treatment of LRPH. SLTH may help to perform LRPH by increasing the level of laparoscopic exposure of the right liver and reducing bleeding and operating time.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal treatment of colorectal liver metastases: Where are we? Current strategies and future perspectives. 多模式治疗结直肠癌肝转移：进展如何？当前战略和未来展望。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2025-03-18 DOI: 10.5582/bst.2025.01012

Caterina Accardo, Ivan Vella, Fabrizio di Francesco, Sergio Rizzo, Sergio Calamia, Alessandro Tropea, Pasquale Bonsignore, Sergio Li Petri, Salvatore Gruttadauria

{"title":"Multimodal treatment of colorectal liver metastases: Where are we? Current strategies and future perspectives.","authors":"Caterina Accardo, Ivan Vella, Fabrizio di Francesco, Sergio Rizzo, Sergio Calamia, Alessandro Tropea, Pasquale Bonsignore, Sergio Li Petri, Salvatore Gruttadauria","doi":"10.5582/bst.2025.01012","DOIUrl":"https://doi.org/10.5582/bst.2025.01012","url":null,"abstract":"Despite the continued high prevalence of colorectal cancer in the Western world, recent years have witnessed a decline in its mortality rate, largely attributable to the sustained advancement of multimodal treatment modalities for metastatic patients. One persisting issue is lack of consensus between different centres and multidisciplinary teams regarding definition of resectability, the duration of chemotherapy treatment, and surgical strategy. This narrative review outlines current multimodal treatment of patients with colon cancer metastatic to the liver and/or lung in different clinical scenarios. Currently, there are multiple multimodal strategies that can be employed to enhance resectability in these patients. These include novel and sophisticated target therapies (such as novel immunotherapeutic modalities and micro RNAs), complex resections utilising parenchyma-sparing techniques, liver transplantation, and cytoreductive strategies in patients for whom a curative option is not feasible. It is the responsibility of the scientific community to establish standardised protocols across different centres, based on the most recent evidence, while maintaining a high degree of personalisation of treatment for each individual patient. It seems likely that artificial intelligence (AI) will play a significant role in achieving this goal.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N⁵-((perfluorophenyl)amino)glutamine regulates BACE1, tau phosphorylation, synaptic function, and neuroinflammation in Alzheimer's disease models. N5-（（全氟苯基）氨基）谷氨酰胺调节BACE1、tau磷酸化、突触功能和阿尔茨海默病模型中的神经炎症。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2025-03-06 Epub Date: 2025-01-25 DOI: 10.5582/bst.2024.01360

Jun-Sik Kim, Yongeun Cho, Jeongmi Lee, Heewon Cho, Sukmin Han, Yeongyeong Lee, Yeji Jeon, Tai Kyoung Kim, Ju-Mi Hong, Jeonghyeong Im, Minshik Chae, Yujeong Lee, Hyunwook Kim, Sang Yoon Park, Sung Hyun Kim, Joung Han Yim, Dong-Gyu Jo

{"title":"N5-((perfluorophenyl)amino)glutamine regulates BACE1, tau phosphorylation, synaptic function, and neuroinflammation in Alzheimer's disease models.","authors":"Jun-Sik Kim, Yongeun Cho, Jeongmi Lee, Heewon Cho, Sukmin Han, Yeongyeong Lee, Yeji Jeon, Tai Kyoung Kim, Ju-Mi Hong, Jeonghyeong Im, Minshik Chae, Yujeong Lee, Hyunwook Kim, Sang Yoon Park, Sung Hyun Kim, Joung Han Yim, Dong-Gyu Jo","doi":"10.5582/bst.2024.01360","DOIUrl":"10.5582/bst.2024.01360","url":null,"abstract":"Alzheimer's disease (AD) is the most common type of dementia. Its incidence is rising rapidly as the global population ages, leading to a significant social and economic burden. AD involves complex pathologies, including amyloid plaque accumulation, synaptic dysfunction, and neuroinflammation. This study explores the therapeutic potential of N 5 -((perfluorophenyl)amino)glutamine (RA-PF), a derivative of γ-glutamyl-N'-(2-hydroxyphenyl)hydrazide (Ramalin), a compound with antioxidant and anti-inflammatory properties. Administration of RA-PF to 5xFAD mice decreases BACE1, reduces Aβ plaque deposition, inhibits microglial activation, restores synaptic transmission, and improves mitochondrial motility, leading to the recovery of cognitive function. Additionally, RA-PF treatment in 3xTg-AD mice alleviates anxiety-like behaviors, tau phosphorylation via inactivating GSK-3β, and BACE1 expression. Further transcriptomic analysis reveals RA-PF treatment in AD mice models recovers phagosome, inflammation, NOD-like receptor, presynaptic membrane, and postsynaptic membrane related signaling pathways. These findings suggest that RA-PF effectively targets multiple aspects of AD pathology, offering a novel multi-target approach for AD treatment.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"102-115"},"PeriodicalIF":5.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From light to insight: Functional near-infrared spectroscopy for unravelling cognitive impairment during task performance. 从光到洞察力：功能性近红外光谱在任务执行过程中揭示认知障碍。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2025-03-06 Epub Date: 2025-01-25 DOI: 10.5582/bst.2024.01362

Na Liu, Lingling Yang, Xiuqing Yao, Yaxi Luo

{"title":"From light to insight: Functional near-infrared spectroscopy for unravelling cognitive impairment during task performance.","authors":"Na Liu, Lingling Yang, Xiuqing Yao, Yaxi Luo","doi":"10.5582/bst.2024.01362","DOIUrl":"10.5582/bst.2024.01362","url":null,"abstract":"Cognitive impairment refers to the impairment of higher brain functions such as perception, thinking or memory that affects the individual's ability to perform daily or social activities. Studies have found that changes in neuronal activity during tasks in patients with cognitive impairment are closely related to changes in cerebral cortical hemodynamics. Functional near-infrared spectroscopy is an indirect method to measure neural activity based on changes in blood oxygen concentration in the cerebral cortex. Due to its strong anti-motion interference, high compatibility, and almost no restriction on participants and environment, it has shown great potential in the research field of cognitive impairment. Recognizing these benefits, this comprehensive review systematically elucidates the rationale, historical development, advantages and disadvantages of functional near-infrared spectroscopy, and also discusses the applications of combining functional near-infrared spectroscopy with other detection techniques. Additionally, this review summarized how functional near-infrared spectroscopy can be applied to cognitive impairment caused by different diseases, ultimately aiding the study of neural mechanisms of cognitive activities, which is crucial for the diagnosis, differentiation and treatment of cognitive impairment.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"53-71"},"PeriodicalIF":5.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0