Bioscience trends最新文献_第3页

Compare antiretroviral drug concentrations in hair and plasma across EFV-based regimens in China. 比较中国基于efv的治疗方案中头发和血浆中的抗逆转录病毒药物浓度。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2025-07-23 DOI: 10.5582/bst.2025.01157

Yuan Guan, Lai Wei, Ye Tao, Hanlu Jia, Li Gao, Lingling Huang, Yingying Zhan, Xue Zhang, Aiping Yu, Yan Zhao

{"title":"Compare antiretroviral drug concentrations in hair and plasma across EFV-based regimens in China.","authors":"Yuan Guan, Lai Wei, Ye Tao, Hanlu Jia, Li Gao, Lingling Huang, Yingying Zhan, Xue Zhang, Aiping Yu, Yan Zhao","doi":"10.5582/bst.2025.01157","DOIUrl":"https://doi.org/10.5582/bst.2025.01157","url":null,"abstract":"Effective antiretroviral therapy (ART) depends on adequate drug exposure. Plasma ART concentrations provide a short-term assessment of drug exposure, and hair promises to be an alternative matrix for measuring long-term exposure. We aimed to determine the association between plasma and hair ART concentrations and explore the therapeutic concentrations in hair. A cohort study in which HIV-infected adults receiving tenofovir disoproxil fumarate (TDF) + lamivudine (3TC) + efavirenz (EFV) regimen for at 6 months were recruited and paired hair and plasma samples collected at about 6±1 months of ART. Previously validated liquid chromatography and tandem mass spectrometry methods were used to measure ART concentrations in plasma and hair. Among 74 participants enrolled, 47 used a 400 mg dose of EFV daily and 27 used 600 mg EFV daily. Hair and plasma EFV concentrations were strongly correlated, with particularly strong association observed in the 600 mg EFV group. The hair EFV concentration of female participants was significantly higher than in male participants, which might be the inter-individual variations in the drug metabolism and dissolution and life habits. The concentrations of TDF and 3TC in hair are too low to determine effective threshold and relationship with plasma drugs concentrations. The accumulation and correlation of hair and plasma EFV concentrations promise to determine a therapeutic range in hair. The therapeutic range for EFV in hair needs to be calculated in order to give quantitative results more value within the field of drug exposure assessment.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic potentials of mesenchymal stem cell-derived exosomes for major solid malignancies: A narrative systematic review. 间充质干细胞来源的外泌体对主要实体恶性肿瘤的治疗潜力：叙述系统综述。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2025-07-20 DOI: 10.5582/bst.2025.01120

Xiujuan Wang, Zhe Pan, Nian Liu, Xunan Dai, Ying Yang, Chun Zhang, Yongsheng Xu

{"title":"Therapeutic potentials of mesenchymal stem cell-derived exosomes for major solid malignancies: A narrative systematic review.","authors":"Xiujuan Wang, Zhe Pan, Nian Liu, Xunan Dai, Ying Yang, Chun Zhang, Yongsheng Xu","doi":"10.5582/bst.2025.01120","DOIUrl":"https://doi.org/10.5582/bst.2025.01120","url":null,"abstract":"Treatments for solid tumors, the most common malignant neoplasms, are often confounded by tumor microenvironments that impede the achievement of uniform anti-tumor effects throughout the entire malignant mass, which contributes to recurrence and progression, negatively impacting clinical outcomes. Improved treatment methods for solid malignancies are therefore needed. Mesenchymal stromal cells (MSCs) have been investigated for treatments for various types of solid tumor cancers due to their ability to target tumor cells with similar cell surface protein profiles. MSC-derived exosomes (MSC-Exos) elicit many of the tumor cell responses produced by MSC with no potential for differentiation and reduced risks of adverse effects. We surveyed the literature and clinical trials registries to identify studies investigating MSC-Exo-based anti-cancer therapies for gastric cancer, colorectal cancer, breast cancer, lung cancer, brain cancer, pancreatic cancer, and urological malignancies, and summarize the results of relevant studies herein to provide a comprehensive description of the therapeutic effects and potential clinical applications of MSC-Exos for the treatment of solid tumor malignancies. We include a summary of relevant clinical trials performed to date in an attempt to assess the data available regarding MSC-Exo safety, and propose future efforts regarding the requirements for transitioning forward from phase-1, 2 trials.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal treatment of colorectal liver metastases: Where are we? Current strategies and future perspectives. 多模式治疗结直肠癌肝转移：进展如何？当前战略和未来展望。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2025-07-04 Epub Date: 2025-03-18 DOI: 10.5582/bst.2025.01012

Caterina Accardo, Ivan Vella, Fabrizio di Francesco, Sergio Rizzo, Sergio Calamia, Alessandro Tropea, Pasquale Bonsignore, Sergio Li Petri, Salvatore Gruttadauria

{"title":"Multimodal treatment of colorectal liver metastases: Where are we? Current strategies and future perspectives.","authors":"Caterina Accardo, Ivan Vella, Fabrizio di Francesco, Sergio Rizzo, Sergio Calamia, Alessandro Tropea, Pasquale Bonsignore, Sergio Li Petri, Salvatore Gruttadauria","doi":"10.5582/bst.2025.01012","DOIUrl":"10.5582/bst.2025.01012","url":null,"abstract":"Despite the continued high prevalence of colorectal cancer in the Western world, recent years have witnessed a decline in its mortality rate, largely attributable to the sustained advancement of multimodal treatment modalities for metastatic patients. One persisting issue is lack of consensus between different centres and multidisciplinary teams regarding definition of resectability, the duration of chemotherapy treatment, and surgical strategy. This narrative review outlines current multimodal treatment of patients with colon cancer metastatic to the liver and/or lung in different clinical scenarios. Currently, there are multiple multimodal strategies that can be employed to enhance resectability in these patients. These include novel and sophisticated target therapies (such as novel immunotherapeutic modalities and micro RNAs), complex resections utilising parenchyma-sparing techniques, liver transplantation, and cytoreductive strategies in patients for whom a curative option is not feasible. It is the responsibility of the scientific community to establish standardised protocols across different centres, based on the most recent evidence, while maintaining a high degree of personalisation of treatment for each individual patient. It seems likely that artificial intelligence (AI) will play a significant role in achieving this goal.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"309-327"},"PeriodicalIF":5.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SNRPA promotes hepatocellular carcinoma proliferation and lenvatinib resistance via B7-H6-STAT3/AKT axis by facilitating B7-H6 pre-mRNA maturation. SNRPA通过B7-H6- stat3 /AKT轴促进B7-H6前mrna成熟，促进肝癌增殖和lenvatinib耐药。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2025-07-04 Epub Date: 2025-04-15 DOI: 10.5582/bst.2025.01036

Jiejun Hu, Junhua Gong, Xia Shu, Xin Dai, Dong Cai, Zhibo Zhao, Jinhao Li, Guochao Zhong, Jianping Gong

{"title":"SNRPA promotes hepatocellular carcinoma proliferation and lenvatinib resistance via B7-H6-STAT3/AKT axis by facilitating B7-H6 pre-mRNA maturation.","authors":"Jiejun Hu, Junhua Gong, Xia Shu, Xin Dai, Dong Cai, Zhibo Zhao, Jinhao Li, Guochao Zhong, Jianping Gong","doi":"10.5582/bst.2025.01036","DOIUrl":"10.5582/bst.2025.01036","url":null,"abstract":"The pre-mRNAs splicing is important mechanisms of hepatocellular carcinoma (HCC) progression. Hence, this study aimed to explore the function and corresponding mechanisms of small nuclear ribonucleoprotein polypeptide A (SNRPA), a vital RNAs splicing molecule, in HCC. Here, the University of Alabama at Birmingham CANcer data analysis portal (UALCAN), western blotting, and immunohistochemistry indicated that SNRPA levels were elevated in HCC tissues. Moreover, high expression of SNRPA was correlated with unfavorable clinicopathologic features and poor survival in HCC patients. A series of in vitro and in vivo gain/loss-of-function experiments reported that SNRPA promoted the proliferation of HCC cells. Integrated nanopore full-length cDNA sequencing and RNA-binding protein immunoprecipitation sequencing revealed that B7 homologue 6 (B7-H6) was a potential target of SNRPA. Subsequently, western blotting and flow cytometry showed that SNRPA activated B7-H6-STAT3/AKT signaling axis in HCC cells with promotion of G1-S transition in the cell cycle and inhibition of cell apoptosis. Mechanistically, RNA-binding protein immunoprecipitation and polymerase chain reaction with using exon-exon and exon-intron junction primers revealed that SNRPA facilitated B7-H6 pre-mRNA maturation by binding to it directly and contributing to its intron 2 splicing. Moreover, drug sensitivity test found that SNRPA induced HCC cell resistance to lenvatinib. Finally, restoration experiments demonstrated that the effects of SNRPA on HCC cells relied on B7- H6 expression. Taken together, SNRPA promotes HCC growth and lenvatinib resistance via B7-H6-STAT3/AKT axis through facilitating B7-H6 pre-mRNA maturation by maintaining its intron 2 splicing. Thus, SNRPA may be a promising target for HCC therapy and lenvatinib resistance reversion.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"337-350"},"PeriodicalIF":5.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrative neurorehabilitation using brain-computer interface: From motor function to mental health after stroke. 脑机接口综合神经康复：从脑卒中后的运动功能到心理健康。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2025-07-04 Epub Date: 2025-04-17 DOI: 10.5582/bst.2025.01109

Ya-Nan Ma, Kenji Karako, Peipei Song, Xiqi Hu, Ying Xia

{"title":"Integrative neurorehabilitation using brain-computer interface: From motor function to mental health after stroke.","authors":"Ya-Nan Ma, Kenji Karako, Peipei Song, Xiqi Hu, Ying Xia","doi":"10.5582/bst.2025.01109","DOIUrl":"10.5582/bst.2025.01109","url":null,"abstract":"Stroke remains a leading cause of mortality and long-term disability worldwide, frequently resulting in impairments in motor control, cognition, and emotional regulation. Conventional rehabilitation approaches, while partially effective, often lack individualization and yield suboptimal outcomes. In recent years, brain-computer interface (BCI) technology has emerged as a promising neurorehabilitation tool by decoding neural signals and providing real-time feedback to enhance neuroplasticity. This review systematically explores the use of BCI systems in post-stroke rehabilitation, focusing on three core domains: motor function, cognitive capacity, and emotional regulation. This review outlines the neurophysiological principles underpinning BCI-based motor rehabilitation, including neurofeedback training, Hebbian plasticity, and multimodal feedback strategies. It then examines recent advances in upper limb and gait recovery using BCI integrated with functional electrical stimulation (FES), robotics, and virtual reality (VR). Moreover, it highlights BCI's potential in cognitive and language rehabilitation through EEG-based neurofeedback and the integration of artificial intelligence (AI) and immersive VR environments. In addition, it discusses the role of BCI in monitoring and regulating post-stroke emotional disorders via closed-loop systems. While promising, BCI technologies face challenges related to signal accuracy, device portability, and clinical validation. Future research should prioritize multimodal integration, AI-driven personalization, and large-scale randomized trials to establish long-term efficacy. This review underscores BCI's transformative potential in delivering intelligent, personalized, and cross-domain rehabilitation solutions for stroke survivors.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"243-251"},"PeriodicalIF":5.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver exposure during laparoscopic right-sided hepatectomy via stretching of the ligamentum teres hepatis: A propensity score matching analysis. 经肝圆韧带拉伸的腹腔镜右侧肝切除术中肝脏暴露：倾向评分匹配分析。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2025-07-04 Epub Date: 2025-04-09 DOI: 10.5582/bst.2025.01044

Keda Song, Yang Xu, Zhongyu Li, Mingyuan Wang, Dong Chen, Yongzhi Zhou, Guangchao Yang, Yong Ma

{"title":"Liver exposure during laparoscopic right-sided hepatectomy via stretching of the ligamentum teres hepatis: A propensity score matching analysis.","authors":"Keda Song, Yang Xu, Zhongyu Li, Mingyuan Wang, Dong Chen, Yongzhi Zhou, Guangchao Yang, Yong Ma","doi":"10.5582/bst.2025.01044","DOIUrl":"10.5582/bst.2025.01044","url":null,"abstract":"One of the challenges of laparoscopic liver resection (LLR) is the exposure of the surgical field. We propose a new surgical approach to better expose the right liver, stretching of the ligamentum teres hepatis (SLTH), and we evaluated its clinical feasibility and limitations through a study analyzing relevant cases. Clinicopathologic data on patients who underwent laparoscopic right partial hepatectomy (LRPH) at our center were retrospectively collected, and subjects were 276 patients with liver space-occupying lesions who met the selection criteria and who underwent the new surgical approach (SLTH) or the conventional surgical approach (no stretching of the ligamentum teres hepatis, or NSLTH). After 1:1 propensity score matching (PSM), 102 patients in each cohort were selected for further analysis. There were no significant differences in the operating time or the duration of postoperative hospitalization between the SLTH cohort and the NSLTH cohort. The duration of detachment of the hepatic parenchyma and the duration of hepatic portal occlusion were significantly shorter in the SLTH cohort than in the NSLTH cohort. The intraoperative blood loss in the SLTH cohort was significantly less than that in the NSLTH cohort. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were significantly lower in the SLTH cohort than in the NSLTH cohort on day 5 postoperatively. Results confirmed that SLTH is a simple, safe, effective, and highly reproducible technique for the treatment of LRPH. SLTH may help to perform LRPH by increasing the level of laparoscopic exposure of the right liver and reducing bleeding and operating time.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"361-367"},"PeriodicalIF":5.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet count as a double-edged sword: The impact of thrombocytosis and thrombocytopenia on long-term outcomes after hepatic resection for hepatocellular carcinoma. 血小板计数是一把双刃剑：血小板增多和血小板减少对肝癌肝切除术后长期预后的影响。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2025-07-04 Epub Date: 2025-04-22 DOI: 10.5582/bst.2025.01067

Xuedong Wang, Pengfei Wang, Bingjun Tang, Jiahao Xu, Baidong Wang, Lihui Gu, Yingjian Liang, Hongwei Guo, Han Liu, Yifan Wu, Hong Wang, Yahao Zhou, Yongyi Zeng, Yongkang Diao, Lanqing Yao, Mingda Wang, Chao Li, Timothy M Pawlik, Feng Shen, Lei Cai, Tian Yang

{"title":"Platelet count as a double-edged sword: The impact of thrombocytosis and thrombocytopenia on long-term outcomes after hepatic resection for hepatocellular carcinoma.","authors":"Xuedong Wang, Pengfei Wang, Bingjun Tang, Jiahao Xu, Baidong Wang, Lihui Gu, Yingjian Liang, Hongwei Guo, Han Liu, Yifan Wu, Hong Wang, Yahao Zhou, Yongyi Zeng, Yongkang Diao, Lanqing Yao, Mingda Wang, Chao Li, Timothy M Pawlik, Feng Shen, Lei Cai, Tian Yang","doi":"10.5582/bst.2025.01067","DOIUrl":"10.5582/bst.2025.01067","url":null,"abstract":"The prognostic significance of preoperative platelet counts among patients with hepatocellular carcinoma (HCC) undergoing curative resection remains controversial. The objective of the current study was to investigate the impact of preoperative platelet count on long-term outcomes after HCC resection. Patients who underwent curative-intent resection for HCC between 2000 and 2021 at 10 hepatobiliary centers in China were retrospectively analyzed. Patients were categorized based on platelet count within 2 weeks before surgery: thrombocytopenia (< 100 × 109/L), normal platelet count (100-299 × 109/L), and thrombocytosis (≥ 300 × 109/L). The primary outcomes were overall survival (OS) and recurrence-free survival (RFS). Among 3,116 patients, 655 (21.0%) had thrombocytopenia, 2,374 (76.2%) had normal platelet counts, and 87 (2.8%) had thrombocytosis. The 5-year OS was 52.7%, 56.0%, and 40.2% for thrombocytopenia, normal platelet count, and thrombocytosis groups, respectively (p < 0.001 among the three groups); the corresponding 5-year RFS was 39.3%, 39.3%, and 26.9%, respectively (p = 0.001 among the three groups). Multivariable analysis identified both thrombocytopenia (HR 1.215, 95% CI 1.045-1.413, p = 0.011) and thrombocytosis (HR 1.307, 95% CI 1.130-1.511, p < 0.001) as independent risk factors for worse OS, and thrombocytosis was independently associated with worse RFS (HR 1.523, 95% CI 1.196-1.939, p = 0.001). Both thrombocytopenia and thrombocytosis were associated with worse survival after HCC resection, with thrombocytosis also predicting higher risk of recurrence. Routine preoperative platelet count may serve as a valuable and practical prognostic marker for risk stratification among patients with HCC undergoing resection.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"351-360"},"PeriodicalIF":5.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing precision medicine in immune checkpoint blockade for HIV/AIDS: Current strategies and future directions. 推进艾滋病免疫检查点阻断的精准医学：当前策略和未来方向。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2025-07-04 Epub Date: 2025-04-29 DOI: 10.5582/bst.2025.01072

Xiangyi Tang, Cheng Wang, Xiling Zhang, Qibin Liao, Hongzhou Lu

{"title":"Advancing precision medicine in immune checkpoint blockade for HIV/AIDS: Current strategies and future directions.","authors":"Xiangyi Tang, Cheng Wang, Xiling Zhang, Qibin Liao, Hongzhou Lu","doi":"10.5582/bst.2025.01072","DOIUrl":"10.5582/bst.2025.01072","url":null,"abstract":"Acquired immunodeficiency syndrome (AIDS)/human immunodeficiency virus (HIV) patients experience significant increase in their survival and decline in the mortality with the advent of antiretroviral therapy (ART). Nonetheless, ART alone still cannot completely cure AIDS/HIV patients. Furthermore, the virus remains latent in resting CD4+T cells for extended periods, posing a continuous threat to AIDS/HIV patients. Immune checkpoint blockades (ICBs), as a promising immunotherapy, inaugurate new pathways for AIDS/HIV cure or remission given their capability to break down the latency limit of HIV, and promote the regeneration and activation of HIV-specific T cells. However, not all AIDS/HIV patients respond to immune checkpoint inhibitors (ICIs), similar to that encountered in cancer patients, accompanied by the risk of severe immune-related adverse events (irAEs) in some cases. Accordingly, the present study was conducted to explore the possibility of personalized medicine tailored to the host discrepancy, with purposes of achieving better treatment outcomes, higher objective response rates, and fewer irAEs. Strategies for ICIs based on individual differences are documented to be conducive to improving therapeutic outcomes for patients. Therefore, this study intended to improving the therapeutic efficacy of ICIs in AIDS/HIV patients within the context of precision immunotherapy, including monotherapy and combination strategies, as well as the application of predictive biomarkers.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"296-308"},"PeriodicalIF":5.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current status and perspectives of molecular mechanisms of gender difference in hepatocellular carcinoma: The tip of the iceberg? 肝细胞癌性别差异分子机制的现状与展望：冰山一角？

IF 5.7 4区生物学

Bioscience trends Pub Date : 2025-07-04 Epub Date: 2025-04-22 DOI: 10.5582/bst.2025.01103

Zhi-Quan Xu, Shi-Qiao Luo, Zhong-Jun Wu, Rui Liao

{"title":"Current status and perspectives of molecular mechanisms of gender difference in hepatocellular carcinoma: The tip of the iceberg?","authors":"Zhi-Quan Xu, Shi-Qiao Luo, Zhong-Jun Wu, Rui Liao","doi":"10.5582/bst.2025.01103","DOIUrl":"10.5582/bst.2025.01103","url":null,"abstract":"Hepatocellular carcinoma (HCC) risk factors and incidence vary globally, but men generally have higher incidence than women. Men also tend to have a worse prognosis in terms of survival period and pathological characteristics. Furthermore, there are notable gender differences in treatment strategies and drug responses. While traditional risk factors such as hepatitis B virus, hepatitis C virus, alcohol consumption, and metabolic syndrome contribute to these differences, the underlying molecular mechanisms remain partly understood. Recent research has focused on elucidating the roles of sex hormones, DNA damage and repair pathways, immune microenvironments, and genetic/epigenetic factors in driving gender-specific disparities. For instance, estrogen receptor signaling has been shown to suppress HCC progression, whereas androgen receptor signaling promotes tumor development. Additionally, immune cells such as tumor-associated macrophages and regulatory T cells exhibit gender-specific patterns, with males typically showing higher levels of immunosuppressive cells. Omics analyses, including genomics, transcriptomics, and proteomics, have further revealed sex-specific differences in gene expression, protein interactions, and metabolic pathways. Despite these advances, significant gaps remain in understanding the interplay between environmental, hormonal, and genetic factors in shaping gender disparities in HCC. Future research should prioritize the identification of novel molecular targets, the development of gender-specific therapeutic strategies, and the integration of multi-omics data to address these disparities. Addressing these challenges will be critical for improving diagnostic, prognostic, and therapeutic outcomes in HCC patients of both sexes.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"266-280"},"PeriodicalIF":5.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing hepatobiliary diagnosis and treatment using shortwave-infrared fluorescence imaging with ICG-C9. 利用ICG-C9短波红外荧光成像技术推进肝胆诊断和治疗。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2025-07-04 Epub Date: 2025-06-14 DOI: 10.5582/bst.2025.01113

Kosuke Hatta, Ryota Tanaka, Kenjiro Kimura, Naoki Yamashita, Jie Li, Terufusa Kunisada, Takeaki Ishizawa

{"title":"Advancing hepatobiliary diagnosis and treatment using shortwave-infrared fluorescence imaging with ICG-C9.","authors":"Kosuke Hatta, Ryota Tanaka, Kenjiro Kimura, Naoki Yamashita, Jie Li, Terufusa Kunisada, Takeaki Ishizawa","doi":"10.5582/bst.2025.01113","DOIUrl":"10.5582/bst.2025.01113","url":null,"abstract":"Indocyanine green (ICG)-C9, a novel cyanine dye developed by the Center for Biosystems Dynamics Research at RIKEN, provides significant advantages over conventional ICG due to its detectability via shortwave-infrared (SWIR) fluorescence imaging. Unlike standard ICG, ICG-C9 facilitates SWIR imaging and displays therapeutic potential when conjugated with antibodies in vivo, suggesting broader applicability across various cancer types. This study evaluated the efficacy of SWIR fluorescence imaging with ICG-C9 in comparison with existing near-infrared (NIR) imaging techniques. We assessed excretion kinetics and the relationship between excitation and fluorescence wavelengths for ICG-C9 and ICG following intravenous administration in BALB/c-nu mice. Tumor uptake was evaluated using a cell-line-derived subcutaneous tumor model from HuH-7 cells, representing hepatocellular carcinoma. Variables including dose, administration route, and exposure time were optimized for comparison. Maximum fluorescence intensity for ICG-C9 was observed with an excitation wavelength of 915 nm and fluorescence emission wavelengths >950 nm within the SWIR spectrum. Both ICG-C9 and ICG followed similar excretion pathways, involving hepatic uptake and biliary excretion. Tumor uptake of ICG-C9 was confirmed under similar conditions to ICG. ICG-C9 demonstrates promising potential as an alternative to NIR fluorescence imaging with ICG, offering unique properties that may enhance imaging capabilities. However, further research is required to establish its clinical applicability and broader therapeutic utility.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":" ","pages":"328-336"},"PeriodicalIF":5.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0