Bioscience trends最新文献_第3页

Ligustrazine alleviates the progression of coronary artery calcification by inhibiting caspase-3/GSDME mediated pyroptosis. 利格列嗪通过抑制caspase-3/GSDME介导的热蛋白沉积，缓解冠状动脉钙化的进展。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2024-07-06 DOI: 10.5582/bst.2024.01096

Honghui Yang, Guian Xu, Qingman Li, Lijie Zhu

{"title":"Ligustrazine alleviates the progression of coronary artery calcification by inhibiting caspase-3/GSDME mediated pyroptosis.","authors":"Honghui Yang, Guian Xu, Qingman Li, Lijie Zhu","doi":"10.5582/bst.2024.01096","DOIUrl":"https://doi.org/10.5582/bst.2024.01096","url":null,"abstract":"Coronary artery calcification (CAC) is an early marker for atherosclerosis and is mainly induced by the osteoblast-like phenotype conversion of vascular smooth muscle cells (VSMCs). Recent reports indicate that NOD-like receptor protein 3 (NLRP3)-mediated pyroptosis plays a significant role in the calcification of vascular smooth muscle cells (VSMCs), making it a promising target for treating calcific aortic valve disease (CAC). Ligustrazine, or tetramethylpyrazine (TMP), has been found effective in various cardiovascular and cerebrovascular diseases and is suggested to inhibit NLRP3-mediated pyroptosis. However, the function of TMP in CAC is unknown. Herein, influences of TMP on β-glycerophosphate (β-GP)-stimulated VSMCs and OPG-/- mice were explored. Mouse Aortic Vascular Smooth Muscle (MOVAS-1) cells were stimulated by β-GP with si- caspase-3, si- Gasdermin E (GSDME) or TMP. Increased calcification, reactive oxygen species (ROS) level, Interleukin-1beta (IL-1β) and Interleukin-18 (IL-18) levels, lactate dehydrogenase (LDH) release, enhanced apoptosis, and activated cysteine-aspartic acid protease-3 (caspase-3)/GSDME signaling were observed in β-GP-stimulated MOVAS-1 cells, which was sharply alleviated by si-caspase-3, si-GSDME or TMP. Furthermore, the impact of TMP on the β-GP-induced calcification and injury in MOVAS-1 cells was abolished by raptinal, an activator of caspase-3. Subsequently, OPG-/- mice were dosed with TMP or TMP combined with raptinal. Calcium deposition, increased nodules, elevated IL-1β and IL-18 levels, upregulated CASP3 and actin alpha 2, smooth muscle (ACTA2), and activated caspase-3/GSDME signaling in OPG-/- mice were markedly alleviated by TMP, which were notably reversed by the co-administration of raptinal. Collectively, TMP mitigated CAC by inhibiting caspase-3/GSDME mediated pyroptosis.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and effect on lipid profiles of Ainuovirine-based regimen versus Efavirenz-based regimen in treatment-naïve people with HIV-1 at week 24: A real-world, retrospective, multi-center cohort study. 基于阿依诺韦林的治疗方案与基于依非韦伦的治疗方案在第24周对HIV-1病毒感染者的疗效及其对血脂的影响：一项真实世界、回顾性、多中心队列研究。

IF 5.7 4区生物学

Bioscience trends Pub Date : 2024-06-06 Epub Date: 2024-04-27 DOI: 10.5582/bst.2024.01070

Hai Long, Quanying He, Yanmei Bi, Yingchun Ke, Xiaoxin Xie, Xiuhong Zhao, Si Tan, Yanhe Luo, Zhong Chen, Xiaoli Yu, Linghua Li

{"title":"Efficacy and effect on lipid profiles of Ainuovirine-based regimen versus Efavirenz-based regimen in treatment-naïve people with HIV-1 at week 24: A real-world, retrospective, multi-center cohort study.","authors":"Hai Long, Quanying He, Yanmei Bi, Yingchun Ke, Xiaoxin Xie, Xiuhong Zhao, Si Tan, Yanhe Luo, Zhong Chen, Xiaoli Yu, Linghua Li","doi":"10.5582/bst.2024.01070","DOIUrl":"10.5582/bst.2024.01070","url":null,"abstract":"This study aimed to compare the efficacy and effect on lipid profiles of Ainuovirine (ANV)- and efavirenz (EFV) -based regimens in treatment-naïve people living with HIV-1 (PLWH) at week 24. The proportion of PLWH achieving HIV-1 RNA < the limit of quantification in the ANV group was significantly higher than that in the EFV group (89.18% vs. 76.04%, P = 0.002). The mean change of log10 HIV-1 RNA from baseline was greater (-4.34 vs. -4.18, P < 0.001), the median change from baseline in CD4+ T cell count increased more (106.00 cells/μL vs. 92.00 cells/μL, P = 0.007) in the ANV group, while the CD4+/CD8+ ratio was similar (0.15 vs. 0.20, P = 0.167) between the two groups. The mean changes from baseline in total cholesterol (-0.02 for ANV vs. 0.25 mmol/L for EFV, P < 0.001), triglyceride (-0.14 for ANV vs. 0.11 mmol/L for EFV, P = 0.024), and low-density lipoprotein cholesterol (-0.07 for ANV vs. 0.15 mmol/L for EFV, P < 0.001) was significantly different between the two groups. The percentage of patients with improved lipid profiles was significantly higher in the ANV group (37.44 %) than in the EFV group (29.55%, P = 0.0495). The incidence of any adverse events in the ANV group was significantly lower than that in the EFV group at week 12 (6.2% vs. 30.7%, P < 0.001) and was comparable at week 24 (3.6% vs. 5.5%, P = 0.28). The ANV-based regimen was well tolerated and lipid-friendly in treatment-naïve PLWH.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Considering traditional Chinese medicine as adjunct therapy in the management of chronic constipation by regulating intestinal flora. 考虑将传统中药作为辅助疗法，通过调节肠道菌群治疗慢性便秘。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-06-06 Epub Date: 2024-03-25 DOI: 10.5582/bst.2024.01036

Ke Wang, Hua Qiu, Fang Chen, Pingping Cai, Fanghua Qi

{"title":"Considering traditional Chinese medicine as adjunct therapy in the management of chronic constipation by regulating intestinal flora.","authors":"Ke Wang, Hua Qiu, Fang Chen, Pingping Cai, Fanghua Qi","doi":"10.5582/bst.2024.01036","DOIUrl":"10.5582/bst.2024.01036","url":null,"abstract":"Chronic constipation is one of the most common gastrointestinal disorders worldwide. Due to changes in diet, lifestyle, and the aging population, the incidence of chronic constipation has increased year by year. It has had an impact on daily life and poses a considerable economic burden. Nowadays, many patients with chronic constipation try to seek help from complementary and alternative therapies, and traditional Chinese medicine (TCM) is often their choice. The intestinal flora play an important role in the pathogenesis of constipation by affecting the body's metabolism, secretion, and immunity. Regulating the intestinal flora and optimizing its composition might become an important prevention and treatment for chronic constipation. TCM has unique advantages in regulating the imbalance of intestinal flora, and its curative effect is precise. Therefore, we reviewed the relationship between intestinal flora and chronic constipation as well as advances in research on TCM as adjunct therapy in the management of chronic constipation by regulating intestinal flora. Some single Chinese herbs and their active ingredients (e.g., Rheum palmatum, Radix Astragalus, and Cistanche deserticola), some traditional herbal formulations (e.g., Jichuan decoction, Zengye decoction, and Zhizhu decoction) and some Chinese patent medicines (e.g., Maren pills and Shouhui Tongbian capsules) that are commonly used to treat chronic constipation by regulating intestinal flora are highlighted and summarized. Moreover, some external forms of TCM, and especially acupuncture, have also been found to improve intestinal movement and alleviate constipation symptoms by regulating intestinal flora. We hope this review can contribute to an understanding of TCM as an adjunct therapy for chronic constipation and that it can provide useful information for the development of more effective constipation therapies.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renal safety of tenofovir alafenamide-based antiretroviral therapy in people with HIV: A mini-review. 基于替诺福韦-阿拉非那胺的抗逆转录病毒疗法对 HIV 感染者的肾脏安全性：微型综述。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-04-24 DOI: 10.5582/bst.2024.01062

Fang Zhao, Hongzhou Lu

引用次数: 0

Comprehensive assessment and treatment strategies for dysphagia in the elderly population: Current status and prospects. 老年人吞咽困难的综合评估和治疗策略：现状与前景。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-04-24 DOI: 10.5582/bst.2024.01100

Xiqi Hu, Ya-nan Ma, Kenji Karako, Wei Tang, Peipei Song, Ying Xia

{"title":"Comprehensive assessment and treatment strategies for dysphagia in the elderly population: Current status and prospects.","authors":"Xiqi Hu, Ya-nan Ma, Kenji Karako, Wei Tang, Peipei Song, Ying Xia","doi":"10.5582/bst.2024.01100","DOIUrl":"https://doi.org/10.5582/bst.2024.01100","url":null,"abstract":"As the population ages, the prevalence of dysphagia among older adults is a growing concern. Age-related declines in physiological function, coupled with neurological disorders and structural changes in the pharynx associated with aging, can result in weakened tongue propulsion, a prolonged reaction time of the submental muscles, delayed closure of the laryngeal vestibule, and delayed opening of the upper esophageal sphincter (UES), increasing the risk of dysphagia. Dysphagia impacts the physical health of the elderly, leading to serious complications such as dehydration, aspiration pneumonia, malnutrition, and even life-threatening conditions, and it also detrimentally affects their psychological and social well-being. There is a significant correlation between frailty, sarcopenia, and dysphagia in the elderly population. Therefore, older adults should be screened for dysphagia to identify both frailty and sarcopenia. A reasonable diagnostic approach for dysphagia involves screening, clinical assessment, and instrumental diagnosis. In terms of treatment, multidisciplinary collaboration, rehabilitation training, and the utilization of new technologies are essential. Future research will continue to concentrate on these areas to enhance the diagnosis and treatment of dysphagia, with the ultimate aim of enhancing the quality of life of the elderly population.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140661521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between abnormal lipid metabolism and Alzheimer's disease: New research has revealed significant findings on the APOE4 genotype in microglia. 脂质代谢异常与阿尔茨海默病之间的联系：新研究揭示了小胶质细胞中 APOE4 基因型的重要发现。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-04-17 DOI: 10.5582/bst.2024.01092

Xiqi Hu, Ya-nan Ma, Ying Xia

{"title":"Association between abnormal lipid metabolism and Alzheimer's disease: New research has revealed significant findings on the APOE4 genotype in microglia.","authors":"Xiqi Hu, Ya-nan Ma, Ying Xia","doi":"10.5582/bst.2024.01092","DOIUrl":"https://doi.org/10.5582/bst.2024.01092","url":null,"abstract":"APOE4 is widely recognized as a genetic risk factor for Alzheimer's disease (AD), implicated in 60-80% of all AD cases. Recent research suggests that microglia carrying the APOE4 genotype display abnormal lipid metabolism and accumulate lipid droplets, which may exacerbate the pathology of AD. Microglia play a critical role in immune surveillance within the central nervous system and are responsible for removing harmful particles and preserving neuronal function. The APOE4 genotype causes abnormal lipid metabolism in microglia, resulting in excessive accumulation of lipid droplets. This accumulation not only impairs the phagocytic and clearance capabilities of microglia but also disrupts their interactions with neurons, resulting in disorganization and neurodegenerative alterations at the neuronal network level. In addition, the presence of APOE4 modifies the metabolic landscape of microglia, particularly affecting purinergic signaling and lipid metabolism, thereby exacerbating the pathological processes of AD. In conclusion, the accumulation of lipid droplets and abnormal lipid metabolism may be critical mechanisms in the progression of AD in microglia carrying the APOE4 genotype.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140691252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevation of circulating DNAs of disease-associated cytokines in serum cell-free DNA from patients with alopecia areata. 斑秃患者血清无细胞 DNA 中疾病相关细胞因子的循环 DNA 升高。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-04-13 DOI: 10.5582/bst.2024.01084

S. Sawamura, T. M. Myangat, I. Kajihara, K. Makino, J. Aoi, S. Masuguchi, Satoshi Fukushima

引用次数: 0

Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance. 维生素 C 通过调节肠道微生物群平衡缓解类风湿性关节炎。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-04-10 DOI: 10.5582/bst.2024.01037

Yanjie Zhang, Sibin Zhen, Hao Xu, Songfang Sun, Ziwei Wang, Mian Li, Liang Zou, Yangyang Zhang, Yan Zhao, Yazhou Cui, Jinxiang Han

{"title":"Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance.","authors":"Yanjie Zhang, Sibin Zhen, Hao Xu, Songfang Sun, Ziwei Wang, Mian Li, Liang Zou, Yangyang Zhang, Yan Zhao, Yazhou Cui, Jinxiang Han","doi":"10.5582/bst.2024.01037","DOIUrl":"https://doi.org/10.5582/bst.2024.01037","url":null,"abstract":"Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic and symmetric in-flammation. Our previous research revealed an imbalance in the gut flora of RA patients and showed that certain gut microbiota can accelerate RA progression by enhancing vitamin C degradation. However, it is unclear whether vitamin C supplementation could improve the gut microbiota to prevent the development of arthritis by interfering with the gut-joint axis. In this work, we aimed to evaluate the effects of vitamin C in regulating the gut microbiota and to elucidate its potential role in the onset and progression of RA in a mouse model, thus providing a basis for the development of new intervention strategies and treatments for RA. In this study, collagen-induced arthritis (CIA) mouse models, biochemical, histological and 16S rRNA microbiological methods were used to investigate the role and possible mechanism of vitamin C in rheumatoid arthritis. The results showed that treatment of CIA mice with vitamin C effectively rescued the gut mi-crobiota imbalance and suppressed the inflammatory response associated with RA, and effectively alleviated arthritis symptoms in mice in which levels of the pro-inflammatory cytokines IL-6 and TNF-α were specifi-cally reduced. In conclusion, our results demonstrate the potential of vitamin C as a potential therapeutic choice for RA.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140719436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A multidisciplinary collaborative diagnosis and rehabilitation program for dysphagia in general hospitals. 综合医院针对吞咽困难的多学科协作诊断和康复计划。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-04-10 DOI: 10.5582/bst.2024.01076

Juan Chen, Lili Dai, Min Guo, Hui Huang, Rongfen He, Hui Jin, Xin Jin, Xiaoxiao Li, Yumin Li, Yonggang Liu, Chao Wang, Yukai Wang, Li Wu, Zhongcheng Xing, Junko Fujitani, Yasuo Sugiura, C. Hinohara, Wei Tang

引用次数: 0

NAD(P)H-quinone oxidoreductase 1 induces complicated effects on mitochondrial dysfunction and ferroptosis in an expression level-dependent manner. NAD(P)H-醌氧化还原酶1以表达水平依赖性的方式诱导线粒体功能障碍和铁中毒的复杂效应。

IF 5.5 4区生物学

Bioscience trends Pub Date : 2024-04-10 DOI: 10.5582/bst.2024.01020

Jaewang Lee, D. Hyun

{"title":"NAD(P)H-quinone oxidoreductase 1 induces complicated effects on mitochondrial dysfunction and ferroptosis in an expression level-dependent manner.","authors":"Jaewang Lee, D. Hyun","doi":"10.5582/bst.2024.01020","DOIUrl":"https://doi.org/10.5582/bst.2024.01020","url":null,"abstract":"NAD(P)H-quinone oxidoreductase 1 (NQO1) is an essential redox enzyme responsible for redox balance and energy metabolism. Despite of its importance, the brain contains high capacity of polyunsaturated fatty acids and maintains low levels of NQO1 expression. In this study, we examined how levels of NQO1 expression affects cell survival in response to toxic insults causing mitochondrial dysfunction and ferroptosis, and whether NQO1 has a potential as a biomarker in different stressed conditions. Following treatment with rotenone, overexpressed NQO1 in SH-SY5Y cells improved cell survival by reducing mitochondrial reductive stress via increased NAD+ supply without mitochondrial biogenesis. However, NQO1 overexpression boosted lipid peroxidation following treatment with RSL3 and erastin. A lipid droplet staining assay showed increased lipid droplets in cells overexpressing NQO1. In contrast, NQO1 knockdown protected cells against ferroptosis by increasing GPX4, xCT, and the GSH/GSSG system. Also, NQO1 knockdown showed lower iron contents and lipid droplets than non-transfectants and cells overexpressing NQO1, even though it could not attenuate cell death when exposed to rotenone. In summary, our study suggests that different NQO1 levels may have advantages and disadvantages depending on the surrounding environments. Thus, regulating NQO1 expression could be a potential supplementary tool when treating neuronal diseases.","PeriodicalId":8957,"journal":{"name":"Bioscience trends","volume":null,"pages":null},"PeriodicalIF":5.5,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140720483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0