帕金森病不同阶段肠道菌群分布和变化:荟萃分析、生物信息学分析和体内模拟

IF 5.7 4区 生物学 Q1 BIOLOGY
Bioscience trends Pub Date : 2025-03-06 Epub Date: 2025-01-25 DOI:10.5582/bst.2024.01352
Tingyue Jiang, Yu Wang, Wenxin Fan, Yifan Lu, Ge Zhang, Jiayuan Li, Renzhi Ma, Mengmeng Liu, Jinli Shi
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引用次数: 0

摘要

帕金森病(PD)是一种进行性疾病,需要有效的分期管理。肠道菌群在PD中的作用虽有研究,但其在不同阶段的变化尚不清楚。本研究采用meta分析、生物信息学分析和体内模拟等方法,探讨PD患者及模型不同阶段肠道菌群分布。鱼藤酮治疗大鼠和mptp诱导小鼠分别建立不同时期的PD模型。比较分析不同阶段PD患者或模型肠道菌群的差异。PD患者与对照组间差异有统计学意义,包括放线菌门、三角变形菌门、梭菌门、毛螺杆菌科、副杆菌门等。通过生物信息学分析,我们发现不同阶段PD患者与对照组之间存在显著差异,包括放线菌门(Actinobacteriota)、甲烷菌门(Methanobacteria)、丹毒杆菌门(Erysipelotrichales)、Prevotellaceae、Parabacteroides、Parabacteroides gordonii等。通过meta分析,我们发现在慢性MPTP模型中,放线菌群(Actinobacteriota)和丹毒菌群(erysipelotricaceae)显著增加,而Prevotellaceae显著减少。PD大鼠和小鼠的运动功能、协调能力、自主活动能力和胃肠功能均出现明显损伤,且晚期组损伤大于早期组。不同阶段PD患者或模型与对照组肠道菌群差异有统计学意义。早期优势菌群为Akkermansia、Alistipes、Anaerotruncus、Bilophila、Rikenellaceae、Verrucomicrobia和Verrucomicrobiae,后期优势菌群为放线菌群(Actinobacteriota)和丹毒菌(erysipelotricaceae)。这些差异可以为后续研究不同阶段PD的治疗及发病机制奠定基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Intestinal microbiota distribution and changes in different stages of Parkinson's disease: A meta-analysis, bioinformatics analysis and in vivo simulation.

Parkinson's disease (PD) is a progressive disease that requires effective staging management. The role of intestinal microbiota in PD has been studied, but its changes at different stages are not clear. In this study, meta- analysis, bioinformatics analysis and in vivo simulation were used to explore the intestinal microbiota distribution of PD patients and models at different stages. Two PD models at different stages were established in rotenone-treated rats and MPTP-induced mice. The differences in the intestinal microbiota among the different stages of PD patients or models were compared and analyzed. There were significant differences between PD patients and controls, including Actinobacteriota, Deltaproteobacteria, Clostridiales, Lachnospiraceae, Parabacteroides, etc. Through bioinformatics analysis, we revealed significant differences between PD patients at different stages and controls, including Actinobacteriota, Methanobacteria, Erysipelotrichales, Prevotellaceae, Parabacteroides, Parabacteroides gordonii, etc. Through meta-analysis, we found that Actinobacteriota and Erysipelotrichaceae had significantly increased in the chronic MPTP model, while Prevotellaceae had significantly decreased. PD rats and mice presented significant damage to motor function, coordination, autonomous activity ability and gastrointestinal function, and the damage in the late group was greater than that in the early group. There were significant differences in intestinal microbiota between PD patients or models at different stages and the control groups. In the early stage, the dominant microbiota are Akkermansia, Alistipes, Anaerotruncus, Bilophila, Rikenellaceae, Verrucomicrobia and Verrucomicrobiae, whereas in the late stage, the dominant microbiota are Actinobacteriota and Erysipelotrichaceae. These differences can lay a foundation for subsequent research on the treatment and mechanism of PD at different stages.

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来源期刊
CiteScore
13.60
自引率
1.80%
发文量
47
审稿时长
>12 weeks
期刊介绍: BioScience Trends (Print ISSN 1881-7815, Online ISSN 1881-7823) is an international peer-reviewed journal. BioScience Trends devotes to publishing the latest and most exciting advances in scientific research. Articles cover fields of life science such as biochemistry, molecular biology, clinical research, public health, medical care system, and social science in order to encourage cooperation and exchange among scientists and clinical researchers.
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